Tetsuo Uno - Publications

Affiliations: 
GNF 
Area:
Protein medicinal chemistry

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Pham GH, Ou W, Bursulaya B, DiDonato M, Herath A, Jin Y, Hao X, Loren J, Spraggon G, Brock A, Uno T, Geierstanger BH, Cellitti S. Tuning a Protein Labeling Reaction to Achieve Highly Site-Selective Lysine Conjugation. Chembiochem : a European Journal of Chemical Biology. PMID 29388367 DOI: 10.1002/cbic.201700611  0.64
2017 Grunewald J, Jin Y, Vance J, Read J, Wang X, Wan Y, Zhou H, Ou W, Klock HE, Peters EC, Uno T, Brock A, Geierstanger BH. Optimization of an Enzymatic Antibody Drug Conjugation Approach based on CoA Analogs. Bioconjugate Chemistry. PMID 28590752 DOI: 10.1021/acs.bioconjchem.7b00236  0.64
2015 Michellys PY, Chen B, Jiang T, Jin Y, Lu W, Marsilje TH, Pei W, Uno T, Zhu X, Wu B, Nguyen TN, Bursulaya B, Lee C, Li N, Kim S, et al. Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 26750252 DOI: 10.1016/j.bmcl.2015.11.049  0.36
2015 Grunewald J, Klock HE, Cellitti SE, Bursulaya B, McMullan D, Jones DH, Chiu HP, Wang X, Patterson P, Zhou H, Vance J, Nigoghossian E, Tong H, Daniel D, Mallet W, ... ... Uno T, et al. Efficient preparation of site-specific antibody-drug conjugates using phosphopantetheinyl transferases. Bioconjugate Chemistry. PMID 26588668 DOI: 10.1021/acs.bioconjchem.5b00558  0.64
2014 Grünewald J, Jones DH, Brock A, Chiu HP, Bursulaya B, Ng K, Vo T, Patterson P, Uno T, Hunt J, Spraggon G, Geierstanger BH. Site-specific dual labeling of proteins by using small orthogonal tags at neutral pH. Chembiochem : a European Journal of Chemical Biology. 15: 1787-91. PMID 25044133 DOI: 10.1002/cbic.201402204  0.64
2014 Thoma G, Blanz J, Bühlmayer P, Drückes P, Kittelmann M, Smith AB, van Eis M, Vangrevelinghe E, Zerwes HG, Che JJ, He X, Jin Y, Lee CC, Michellys PY, Uno T, et al. Syk inhibitors with high potency in presence of blood. Bioorganic & Medicinal Chemistry Letters. 24: 2278-82. PMID 24726806 DOI: 10.1016/j.bmcl.2014.03.075  0.64
2013 Marsilje TH, Pei W, Chen B, Lu W, Uno T, Jin Y, Jiang T, Kim S, Li N, Warmuth M, Sarkisova Y, Sun F, Steffy A, Pferdekamper AC, Li AG, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. Journal of Medicinal Chemistry. 56: 5675-90. PMID 23742252 DOI: 10.1021/jm400402q  0.64
2012 Chiu HP, Grünewald J, Hao X, Brock A, Okach L, Uno T, Geierstanger BH. Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins. Chembiochem : a European Journal of Chemical Biology. 13: 364-6. PMID 22223621 DOI: 10.1002/cbic.201100684  0.64
2011 Ou W, Uno T, Chiu HP, Grünewald J, Cellitti SE, Crossgrove T, Hao X, Fan Q, Quinn LL, Patterson P, Okach L, Jones DH, Lesley SA, Brock A, Geierstanger BH. Site-specific protein modifications through pyrroline-carboxy-lysine residues. Proceedings of the National Academy of Sciences of the United States of America. 108: 10437-42. PMID 21670250 DOI: 10.1073/pnas.1105197108  0.64
2011 Cellitti SE, Ou W, Chiu HP, Grünewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH. D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine. Nature Chemical Biology. 7: 528-30. PMID 21525873 DOI: 10.1038/nchembio.586  0.64
2010 Wei L, Gao X, Warne R, Hao X, Bussiere D, Gu XJ, Uno T, Liu Y. Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1. Bioorganic & Medicinal Chemistry Letters. 20: 3897-902. PMID 20627557 DOI: 10.1016/j.bmcl.2010.05.019  0.64
2010 Jones DH, Cellitti SE, Hao X, Zhang Q, Jahnz M, Summerer D, Schultz PG, Uno T, Geierstanger BH. Site-specific labeling of proteins with NMR-active unnatural amino acids. Journal of Biomolecular Nmr. 46: 89-100. PMID 19669620 DOI: 10.1007/s10858-009-9365-4  0.64
2009 Sharif O, Hu H, Klock H, Hampton EN, Nigoghossian E, Knuth MW, Matzen J, Anderson P, Trager R, Uno T, Glynne RJ, Azarian SM, Caldwell JS, Brinker A. Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4. Analytical Biochemistry. 392: 162-8. PMID 19482004 DOI: 10.1016/j.ab.2009.05.038  0.64
2008 Cellitti SE, Jones DH, Lagpacan L, Hao X, Zhang Q, Hu H, Brittain SM, Brinker A, Caldwell J, Bursulaya B, Spraggon G, Brock A, Ryu Y, Uno T, Schultz PG, et al. In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy Journal of the American Chemical Society. 130: 9268-9281. PMID 18576636 DOI: 10.1021/ja801602q  0.64
2007 Jansma A, Zhang Q, Li B, Ding Q, Uno T, Bursulaya B, Liu Y, Furet P, Gray NS, Geierstanger BH. Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy Journal of Medicinal Chemistry. 50: 5875-5877. PMID 17975906 DOI: 10.1021/jm700983a  0.64
2006 Zhang Q, Liu Y, Gao F, Ding Q, Cho C, Hur W, Jin Y, Uno T, Joazeiro CA, Gray N. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. Journal of the American Chemical Society. 128: 2182-3. PMID 16478150 DOI: 10.1021/ja0567485  0.64
2003 Boussie TR, Diamond GM, Goh C, Hall KA, LaPointe AM, Leclerc M, Lund C, Murphy V, Shoemaker JA, Tracht U, Turner H, Zhang J, Uno T, Rosen RK, Stevens JC. A fully integrated high-throughput screening methodology for the discovery of new polyolefin catalysts: discovery of a new class of high temperature single-site group (IV) copolymerization catalysts. Journal of the American Chemical Society. 125: 4306-17. PMID 12670253 DOI: 10.1021/ja020868k  0.64
1994 Prudent JR, Uno T, Schultz PG. Expanding the scope of RNA catalysis. Science (New York, N.Y.). 264: 1924-7. PMID 8009223  0.52
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