Michael E. Pacold - Publications

2010-2016 Whitehead Institute (MIT), Cambridge, MA, United States 
 2016- Radiation Oncology New York University, New York, NY, United States 
Cancer metabolism, metabolomics

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Banh RS, Kim ES, Spillier Q, Biancur DE, Yamamoto K, Sohn ASW, Shi G, Jones DR, Kimmelman AC, Pacold ME. The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. Nature. PMID 34471290 DOI: 10.1038/s41586-021-03865-w  1
2020 Banh RS, Biancur DE, Yamamoto K, Sohn ASW, Walters B, Kuljanin M, Gikandi A, Wang H, Mancias JD, Schneider RJ, Pacold ME, Kimmelman AC. Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. Cell. PMID 33142117 DOI: 10.1016/j.cell.2020.10.016  0.04
2020 Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL. Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain. Elife. 9. PMID 33043885 DOI: 10.7554/eLife.59699  1
2020 Wu L, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos T, Kimmelman AC, et al. Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. Cell. PMID 32615085 DOI: 10.1016/J.Cell.2020.06.014  0.08
2020 Pacold ME. The uninhibited pathway is not worth studying. Nature Chemical Biology. 16: 713-714. PMID 32572257 DOI: 10.1038/S41589-020-0562-5  0.01
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Pacold ME, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  1
2018 Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science (New York, N.Y.). 362. PMID 30442778 DOI: 10.1126/Science.Aat9528  1
2018 Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry. PMID 29555419 DOI: 10.1016/j.bmc.2018.02.016  1
2018 Lattanzi M, Pacold M, Balar AV. Association of upregulation of serine and one carbon metabolism genes with shorter recurrence-free and overall survival in urothelial bladder cancer (UBC). Journal of Clinical Oncology. 36: 477-477. DOI: 10.1200/Jco.2018.36.6_Suppl.477  0.01
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114  1
2017 Gowen M, Tchack J, Zhou H, Giles KM, Paschke S, Moran U, Fenyo D, Tsirigos A, Pacold M, Pavlick AC, Krogsgaard M, Osman I. Predictive biomarkers of ipilimumab toxicity in metastatic melanoma. Journal of Clinical Oncology. 35: 9559-9559. DOI: 10.1200/Jco.2017.35.15_Suppl.9559  0.04
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, et al. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656. PMID 27434767 DOI: 10.1038/Nchembio0816-656  1
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/Nchembio.2070  1
2015 Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science (New York, N.Y.). PMID 26586190 DOI: 10.1126/Science.Aad2087  1
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/Nature14363  1
2014 LeBaron V, Krishnan MS, Shiloh RY, Racsa M, Pacold ME, Spektor A, Balboni TA. Palliative care issues encountered by radiation oncologists caring for advanced cancer patients. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 14. PMID 28142689 DOI: 10.1200/Jco.2014.32.31_Suppl.14  0.01
2014 Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 158: 1094-109. PMID 25171410 DOI: 10.1016/J.Cell.2014.07.032  1
2014 Tseng YD, Krishnan MS, Jones JA, Sullivan AJ, Gorman D, Taylor A, Pacold M, Kalinowski B, Mamon HJ, Abrahm J, Balboni TA. Supportive and palliative radiation oncology service: impact of a dedicated service on palliative cancer care. Practical Radiation Oncology. 4: 247-53. PMID 25012833 DOI: 10.1016/j.prro.2013.09.005  1
2014 Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Reports. 8: 284-96. PMID 24981863 DOI: 10.1016/J.Celrep.2014.05.048  1
2014 Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie (International Ed. in English). 53: 199-204. PMID 24259466 DOI: 10.1002/Anie.201307387  1
2013 Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (New York, N.Y.). 341: 1236566. PMID 23888043 DOI: 10.1126/Science.1236566  1
2013 Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 498: 246-50. PMID 23728299 DOI: 10.1038/Nature12147  1
2012 Karve S, Werner ME, Sukumar R, Cummings ND, Copp JA, Wang EC, Li C, Sethi M, Chen RC, Pacold ME, Wang AZ. Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. Proceedings of the National Academy of Sciences of the United States of America. 109: 8230-5. PMID 22547809 DOI: 10.1073/Pnas.1120508109  1
2011 Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476: 346-50. PMID 21760589 DOI: 10.1038/Nature10350  1
2008 Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. Journal of Medicinal Chemistry. 51: 4699-707. PMID 18630894 DOI: 10.1021/Jm800374F  1
2004 Misaghi S, Pacold ME, Blom D, Ploegh HL, Korbel GA. Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chemistry & Biology. 11: 1677-87. PMID 15610852 DOI: 10.1016/J.Chembiol.2004.11.010  1
2004 Perisic O, Wilson MI, Karathanassis D, Bravo J, Pacold ME, Ellson CD, Hawkins PT, Stephens L, Williams RL. The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. Advances in Enzyme Regulation. 44: 279-98. PMID 15581496 DOI: 10.1016/J.Advenzreg.2003.11.003  1
2004 Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL. Yeast N-glycanase distinguishes between native and non-native glycoproteins Embo Reports. 5: 201-206. PMID 14726951 DOI: 10.1038/Sj.Embor.7400066  1
2002 Ma Y, Greener T, Pacold ME, Kaushal S, Greene LE, Eisenberg E. Identification of domain required for catalytic activity of auxilin in supporting clathrin uncoating by Hsc70. The Journal of Biological Chemistry. 277: 49267-74. PMID 12377777 DOI: 10.1074/jbc.M203695200  1
2001 Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL. The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Molecular Cell. 8: 829-39. PMID 11684018 DOI: 10.1016/S1097-2765(01)00372-0  1
2001 Clapier CR, De Boer J, Pacold ME, Tamme R, Van Dinten LC. Brakes and gas pedals. Meeting: Spetses 2000, molecular mechanisms of development and disease Embo Reports. 2: 563-567. PMID 11463738 DOI: 10.1093/embo-reports/kve140  1
2000 Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell. 103: 931-43. PMID 11136978 DOI: 10.1016/S0092-8674(00)00196-3  1
2000 Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Molecular Cell. 6: 909-19. PMID 11090628 DOI: 10.1016/S1097-2765(05)00089-4  1
1995 Pacold ME, Stevens FJ, Li D, Anderson LE. The NADP-linked glyceraldehyde-3-phosphate dehydrogenases of Anabaena variabilis and Synechocystis PCC 6803, which lack one of the cysteines found in the higher plant enzyme, are not reductively activated Photosynthesis Research. 43: 125-130. DOI: 10.1007/BF00042969  1
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