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Advait Nagle - Publications

Affiliations: 
2004- Scripps Research Institute 
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus BS, Kreishman-Deitrick M, Bursulaya B, Lai Y, Gao MY, Liang F, Mathison CJN, Liu X, et al. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. Journal of Medicinal Chemistry. PMID 32667203 DOI: 10.1021/Acs.Jmedchem.0C00499  0.367
2020 Rao SPS, Lakshminarayana SB, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram JC, Barrett MP, Diagana TT. Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis. Tropical Medicine and Infectious Disease. 5. PMID 32079320 DOI: 10.3390/Tropicalmed5010028  0.419
2014 Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ, Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, et al. Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. Nature Communications. 5: 5521. PMID 25422853 DOI: 10.1038/Ncomms6521  0.596
2014 Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, et al. Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. Acs Medicinal Chemistry Letters. 5: 947-50. PMID 25147620 DOI: 10.1021/Ml500244M  0.43
2014 Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial Agents and Chemotherapy. 58: 5060-7. PMID 24913172 DOI: 10.1128/Aac.02727-13  0.434
2014 Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, ... ... Nagle A, et al. KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrobial Agents and Chemotherapy. 58: 1586-95. PMID 24366744 DOI: 10.1128/Aac.01927-13  0.352
2013 McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, ... ... Nagle A, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 504: 248-253. PMID 24284631 DOI: 10.1038/Nature12782  0.466
2012 Nagle A, Wu T, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, et al. Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of Medicinal Chemistry. 55: 4244-73. PMID 22524250 DOI: 10.1021/Jm300041E  0.353
2011 Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, ... ... Nagle A, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.). 334: 1372-7. PMID 22096101 DOI: 10.1126/Science.1211936  0.738
2011 Wu T, Nagle A, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Goh A, Lakshminarayana SB, Wu J, Ang HQ, Zeng P, Kang ML, Tan W, et al. Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of Medicinal Chemistry. 54: 5116-30. PMID 21644570 DOI: 10.1021/Jm2003359  0.327
2010 Deng X, Nagle A, Wu T, Sakata T, Henson K, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. Bioorganic & Medicinal Chemistry Letters. 20: 4027-31. PMID 20610151 DOI: 10.1016/J.Bmcl.2010.05.095  0.567
2009 Wu T, Nagle A, Sakata T, Henson K, Borboa R, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorganic & Medicinal Chemistry Letters. 19: 6970-4. PMID 19879133 DOI: 10.1016/J.Bmcl.2009.10.050  0.584
2008 Hur W, Velentza A, Kim S, Flatauer L, Jiang X, Valente D, Mason DE, Suzuki M, Larson B, Zhang J, Zagorska A, Didonato M, Nagle A, Warmuth M, Balk SP, et al. Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase. Bioorganic & Medicinal Chemistry Letters. 18: 5916-9. PMID 18667312 DOI: 10.1016/J.Bmcl.2008.07.062  0.5
2008 Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 105: 9059-64. PMID 18579783 DOI: 10.1073/Pnas.0802982105  0.644
2008 Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nature Chemical Biology. 4: 347-56. PMID 18454143 DOI: 10.1038/Nchembio.87  0.629
2006 Okram B, Nagle A, Adrián FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Wang X, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS. A general strategy for creating "inactive-conformation" abl inhibitors. Chemistry & Biology. 13: 779-86. PMID 16873026 DOI: 10.1016/J.Chembiol.2006.05.015  0.653
2006 Nagle A, Hur W, Gray NS. Antimitotic agents of natural origin. Current Drug Targets. 7: 305-26. PMID 16515529 DOI: 10.2174/138945006776054933  0.49
2006 Okram B, Nagle A, Adrian FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS. A general strategy for creating Chemistry & Biology. 13: 779-786. DOI: 10.2210/Pdb2Hiw/Pdb  0.647
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