Year |
Citation |
Score |
2022 |
Wei J, Zhang X, Zhou Y, Cheng X, Lin Z, Tang M, Zheng J, Wang B, Kang Q, Bai L. Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies. Nature Communications. 13: 6617. PMID 36329057 DOI: 10.1038/s41467-022-34387-2 |
0.376 |
|
2022 |
Saeed AU, Rahman MU, Chen HF, Zheng J. Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin. Molecules (Basel, Switzerland). 27. PMID 36234941 DOI: 10.3390/molecules27196405 |
0.422 |
|
2022 |
Feng Y, Yang X, Ji H, Deng Z, Lin S, Zheng J. The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases. Communications Biology. 5: 508. PMID 35618872 DOI: 10.1038/s42003-022-03477-8 |
0.326 |
|
2022 |
Ali I, Khan A, Fa Z, Khan T, Wei DQ, Zheng J. Crystal structure of Acetyl-CoA carboxylase (AccB) from Streptomyces antibioticus and insights into the substrate-binding through in silico mutagenesis and biophysical investigations. Computers in Biology and Medicine. 145: 105439. PMID 35344865 DOI: 10.1016/j.compbiomed.2022.105439 |
0.385 |
|
2021 |
Guo Y, Li DF, Zheng J, Xu Y, Zhou NY. Single-component and two-component -nitrophenol monooxygenases: structural basis for their catalytic difference. Applied and Environmental Microbiology. AEM0117121. PMID 34469195 DOI: 10.1128/AEM.01171-21 |
0.344 |
|
2020 |
Guo Y, Li DF, Ji H, Zheng J, Zhou NY. Structural and biochemical insights into the substrate selectivity and catalysis of hexachlorobenzene monooxygenase. Applied and Environmental Microbiology. PMID 33097503 DOI: 10.1128/AEM.01965-20 |
0.372 |
|
2019 |
Zhang F, Ji H, Ali I, Deng Z, Bai L, Zheng J. Structural and Biochemical insights to the Recruitment of Acyl Carrier Protein-linked Extender Units in Ansamitocin Biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 31777147 DOI: 10.1002/Cbic.201900628 |
0.453 |
|
2019 |
Zhang F, Shi T, Ji H, Ali I, Huang S, Deng Z, Min Q, Bai L, Zhao YL, Zheng J. Structural Insights into Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase. Biochemistry. PMID 31199122 DOI: 10.1021/acs.biochem.9b00305 |
0.486 |
|
2019 |
Wang L, Yuan M, Zheng J. Crystal structure of the condensation domain from lovastatin polyketide synthase. Synthetic and Systems Biotechnology. 4: 10-15. PMID 30533541 DOI: 10.1016/J.Synbio.2018.11.003 |
0.47 |
|
2019 |
He B, Zhou T, Bu X, Weng J, Xu J, Lin S, Zheng J, Zhao Y, Xu M. Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis Acs Catalysis. 9: 5391-5399. DOI: 10.1021/Acscatal.9B01034 |
0.414 |
|
2018 |
Liu C, Yuan M, Xu X, Wang L, Keatinge-Clay AT, Deng Z, Lin S, Zheng J. Substrate-bound Structures of a Ketoreductase from Amphotericin Modular Polyketide Synthase. Journal of Structural Biology. PMID 29626512 DOI: 10.1016/J.Jsb.2018.04.001 |
0.481 |
|
2018 |
Zhang L, Ji J, Yuan M, Feng Y, Wang L, Deng Z, Bai L, Zheng J. Stereospecificity of enoylreductase domains from modular polyketide synthases. Acs Chemical Biology. PMID 29437374 DOI: 10.1021/Acschembio.7B00982 |
0.406 |
|
2015 |
Sun X, Che C, Ji J, Zheng J, Yang G. [Heterologous expression and substrate specificity of ketoreductase domain in bacillaene polyketide synthase]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 31: 1355-62. PMID 26955713 |
0.342 |
|
2015 |
Wang F, Wang Y, Ji J, Zhou Z, Yu J, Zhu H, Su Z, Zhang L, Zheng J. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. Acs Chemical Biology. 10: 1017-25. PMID 25581064 DOI: 10.1021/Cb500873K |
0.43 |
|
2014 |
Piasecki SK, Zheng J, Axelrod AJ, Detelich ME, Keatinge-Clay AT. Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction. Proteins. 82: 2067-77. PMID 24634061 DOI: 10.1002/Prot.24561 |
0.346 |
|
2013 |
Zheng J, Piasecki SK, Keatinge-Clay AT. Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry. Acs Chemical Biology. 8: 1964-71. PMID 23755878 DOI: 10.1021/Cb400161G |
0.399 |
|
2013 |
Zheng J, Fage CD, Demeler B, Hoffman DW, Keatinge-Clay AT. The missing linker: a dimerization motif located within polyketide synthase modules. Acs Chemical Biology. 8: 1263-70. PMID 23489133 DOI: 10.1021/Cb400047S |
0.412 |
|
2013 |
Zheng J, Keatinge-Clay AT. The status of type i polyketide synthase ketoreductases Medchemcomm. 4: 34-40. DOI: 10.1039/C2Md20191G |
0.415 |
|
2012 |
Fan K, Pan G, Peng X, Zheng J, Gao W, Wang J, Wang W, Li Y, Yang K. Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis. Chemistry & Biology. 19: 1381-90. PMID 23177193 DOI: 10.1016/J.Chembiol.2012.09.009 |
0.354 |
|
2012 |
Zheng J, Gay DC, Demeler B, White MA, Keatinge-Clay AT. Divergence of multimodular polyketide synthases revealed by a didomain structure. Nature Chemical Biology. 8: 615-21. PMID 22634636 DOI: 10.1038/Nchembio.964 |
0.448 |
|
2011 |
Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel DR, Keatinge-Clay AT. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chemistry & Biology. 18: 1331-40. PMID 22035802 DOI: 10.1016/J.Chembiol.2011.07.021 |
0.329 |
|
2011 |
Zheng J, Keatinge-Clay AT. Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases. Journal of Molecular Biology. 410: 105-17. PMID 21570406 DOI: 10.1016/J.Jmb.2011.04.065 |
0.439 |
|
2010 |
Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT. Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Structure (London, England : 1993). 18: 913-22. PMID 20696392 DOI: 10.1016/J.Str.2010.04.015 |
0.473 |
|
2009 |
Zheng J, Sagar V, Smolinsky A, Bourke C, LaRonde-LeBlanc N, Cropp TA. Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin. Journal of Molecular Biology. 387: 1250-60. PMID 19265703 DOI: 10.1016/J.Jmb.2009.02.058 |
0.323 |
|
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