Scott Gray-Owen - Publications

Affiliations: 
Molecular and Medical Genetics University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Immunology

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Chan K, Farias AG, Lee H, Guvenc F, Mero P, Brown KR, Ward H, Billmann M, Aulakh K, Astori A, Haider S, Marcon E, Braunschweig U, Pu S, Habsid A, ... ... Gray-Owen SD, et al. Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors. Heliyon. e12744. PMID 36597481 DOI: 10.1016/j.heliyon.2022.e12744  0.339
2022 Currie EG, Coburn B, Porfilio EA, Lam P, Rojas OL, Novak J, Yang S, Chowdhury RB, Ward LA, Wang PW, Khaleghi K, An J, Crome SQ, Hladunewich MA, Barbour SJ, ... ... Gray-Owen SD, et al. Immunoglobulin A nephropathy is characterized by anti-commensal humoral immune responses. Jci Insight. PMID 35133979 DOI: 10.1172/jci.insight.141289  0.391
2021 Criss AK, Genco CA, Gray-Owen SD, Jerse AE, Seifert HS. Challenges and Controversies Concerning Neisseria gonorrhoeae-Neutrophil Interactions in Pathogenesis. Mbio. e0072121. PMID 34060328 DOI: 10.1128/mBio.00721-21  0.303
2020 Behrens IK, Busch B, Ishikawa-Ankerhold H, Palamides P, Shively JE, Stanners C, Chan C, Leung N, Gray-Owen S, Haas R. The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of in Neutrophils. Mbio. 11. PMID 32019805 DOI: 10.1128/Mbio.03256-19  0.379
2019 Yu Q, Wang LC, Di Benigno S, Gray-Owen SD, Stein DC, Song W. Neisseria gonorrhoeae Infects the Heterogeneous Epithelia of the Human Cervix Using Distinct Mechanisms. Plos Pathogens. 15: e1008136. PMID 31790511 DOI: 10.1371/Journal.Ppat.1008136  0.38
2019 Russell MW, Jerse AE, Gray-Owen SD. Progress Toward a Gonococcal Vaccine: The Way Forward. Frontiers in Immunology. 10: 2417. PMID 31681305 DOI: 10.3389/Fimmu.2019.02417  0.301
2019 Johswich KO, Gray-Owen SD. Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive Disease. Methods in Molecular Biology (Clifton, N.J.). 1969: 149-168. PMID 30877676 DOI: 10.1007/978-1-4939-9202-7_11  0.323
2019 Gray-Owen S, Guvenc F. P689 Turning gonorrhea against HIV: latent HIV ‘shock-and-kill’ using a gonococcal-derived metabolite Sexually Transmitted Infections. 95. DOI: 10.1136/Sextrans-2019-Sti.755  0.386
2019 Fegan J, Islam E, Calmettes C, Yu R, Ahn S, Moraes T, Schryvers A, Gray-Owen S. O01.3 Engineering hybrid bacterial transferrin receptor-based vaccines to confer broad protection against neisseria gonorrhoeae Sexually Transmitted Infections. 95. DOI: 10.1136/Sextrans-2019-Sti.106  0.351
2018 Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM. Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases. Bmc Genomics. 19: 627. PMID 30134832 DOI: 10.1186/S12864-018-5000-7  0.307
2018 O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, et al. High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis. Mbio. 9. PMID 30131363 DOI: 10.1128/Mbio.01581-18  0.437
2018 Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD. Specific binding to differentially-expressed human CEACAMs determines the outcome of infections along the female reproductive tract. Infection and Immunity. PMID 29760215 DOI: 10.1128/Iai.00092-18  0.331
2018 Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO. Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. Mbio. 9. PMID 29362231 DOI: 10.1128/mBio.01755-17  0.325
2017 Sintsova A, Guo CX, Sarantis H, Mak TW, Glogauer M, Gray-Owen SD. Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling. Cellular Microbiology. PMID 28886618 DOI: 10.1111/Cmi.12788  0.349
2017 Gall A, Gaudet RG, Gray-Owen SD, Salama NR. TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection. Mbio. 8. PMID 28811347 DOI: 10.1128/mBio.01168-17  0.313
2017 Gaudet RG, Guo CX, Molinaro R, Kottwitz H, Rohde JR, Dangeard AS, Arrieumerlou C, Girardin SE, Gray-Owen SD. Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway. Cell Reports. 19: 1418-1430. PMID 28514661 DOI: 10.1016/J.Celrep.2017.04.063  0.313
2016 Ostan N, Morgenthau A, Yu RH, Gray-Owen SD, Schryvers AB. A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 1-7. PMID 28129513 DOI: 10.1139/Bcb-2016-0055  0.341
2016 Abdul-Wahid A, Cydzik M, Prodeus A, Alwash M, Stanojcic M, Thompson M, Huang EH, Shively JE, Gray-Owen SD, Gariépy J. Induction of Antigen-Specific TH 9 Immunity Accompanied by Mast Cell Activation Blocks Tumor Cell Engraftment. International Journal of Cancer. PMID 27037842 DOI: 10.1002/Ijc.30121  0.337
2015 Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Science (New York, N.Y.). 348: 1251-5. PMID 26068852 DOI: 10.1126/Science.Aaa4921  0.34
2015 Sintsova A, Wong H, MacDonald KS, Kaul R, Virji M, Gray-Owen SD. Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract. Infection and Immunity. 83: 1372-83. PMID 25605771 DOI: 10.1128/Iai.03123-14  0.314
2014 Sintsova A, Sarantis H, Islam EA, Sun CX, Amin M, Chan CH, Stanners CP, Glogauer M, Gray-Owen SD. Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program. Plos Pathogens. 10: e1004341. PMID 25188454 DOI: 10.1371/Journal.Ppat.1004341  0.421
2014 Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, Kain D, Kim CJ, Leung N, Amin M, Geddes K, Serghides L, Philpott DJ, Kimani J, Gray-Owen S, et al. Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. Journal of Acquired Immune Deficiency Syndromes (1999). 65: 517-25. PMID 24256632 DOI: 10.1097/Qai.0000000000000056  0.421
2013 Johswich KO, McCaw SE, Islam E, Sintsova A, Gu A, Shively JE, Gray-Owen SD. In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa. Plos Pathogens. 9: e1003509. PMID 23935487 DOI: 10.1371/Journal.Ppat.1003509  0.407
2013 Yu Q, Chow EM, McCaw SE, Hu N, Byrd D, Amet T, Hu S, Ostrowski MA, Gray-Owen SD. Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response. Plos One. 8: e56705. PMID 23424672 DOI: 10.1371/Journal.Pone.0056705  0.534
2013 Ossa JC, Ho NK, Wine E, Leung N, Gray-Owen SD, Sherman PM. Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells. Cellular Microbiology. 15: 446-57. PMID 23072252 DOI: 10.1111/Cmi.12048  0.398
2012 Liu Y, Islam EA, Jarvis GA, Gray-Owen SD, Russell MW. Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms. Mucosal Immunology. 5: 320-31. PMID 22354319 DOI: 10.1038/Mi.2012.12  0.32
2012 Sarantis H, Gray-Owen SD. Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae. Infection and Immunity. 80: 345-58. PMID 22064717 DOI: 10.1128/IAI.05702-11  0.409
2011 Ferreira VH, Nazli A, Khan G, Mian MF, Ashkar AA, Gray-Owen S, Kaul R, Kaushic C. Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner. The Journal of Infectious Diseases. 204: 299-308. PMID 21673042 DOI: 10.1093/Infdis/Jir260  0.369
2011 Dobson-Belaire WN, Cochrane A, Ostrowski MA, Gray-Owen SD. Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication. Plos One. 6: e18133. PMID 21526113 DOI: 10.1371/Journal.Pone.0018133  0.353
2011 Sadarangani M, Pollard AJ, Gray-Owen SD. Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria. Fems Microbiology Reviews. 35: 498-514. PMID 21204865 DOI: 10.1111/j.1574-6976.2010.00260.x  0.468
2010 Dobson-Belaire WN, Rebbapragada A, Malott RJ, Yue FY, Kovacs C, Kaul R, Ostrowski MA, Gray-Owen SD. Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells. Cellular Microbiology. 12: 1703-17. PMID 20735437 DOI: 10.1111/J.1462-5822.2010.01502.X  0.342
2008 Sheung A, Rebbapragada A, Shin LY, Dobson-Belaire W, Kimani J, Ngugi E, MacDonald KS, Bwayo JJ, Moses S, Gray-Owen S, Kaul R. Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses. Aids (London, England). 22: 1729-37. PMID 18753933 DOI: 10.1097/Qad.0B013E32830Baf5E  0.403
2008 Lee HS, Ostrowski MA, Gray-Owen SD. CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation. Journal of Immunology (Baltimore, Md. : 1950). 180: 6827-35. PMID 18453603  0.384
2008 Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO. A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin. Infection and Immunity. 76: 48-55. PMID 17938212 DOI: 10.1128/IAI.00980-07  0.323
2007 Sarantis H, Gray-Owen SD. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. Cellular Microbiology. 9: 2167-80. PMID 17506820 DOI: 10.1111/j.1462-5822.2007.00947.x  0.366
2006 Gray-Owen SD, Blumberg RS. CEACAM1: Contact-dependent control of immunity Nature Reviews Immunology. 6: 433-446. PMID 16724098 DOI: 10.1038/Nri1864  0.363
2003 Gray-Owen SD. Neisserial Opa proteins: impact on colonization, dissemination and immunity. Scandinavian Journal of Infectious Diseases. 35: 614-8. PMID 14620144 DOI: 10.1080/00365540310016042  0.366
2002 Boulton IC, Gray-Owen SD. Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nature Immunology. 3: 229-36. PMID 11850628 DOI: 10.1038/ni769  0.467
2000 Dehio C, Gray-Owen SD, Meyer TF. Host cell invasion by pathogenic Neisseriae. Sub-Cellular Biochemistry. 33: 61-96. PMID 10804852 DOI: 10.1007/978-1-4757-4580-1_4  0.366
1998 Gray-Owen SD, Lorenzen DR, Haude A, Meyer TF, Dehio C. Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae. Molecular Microbiology. 26: 971-80. PMID 9426134 DOI: 10.1046/J.1365-2958.1997.6342006.X  0.306
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