Yair Argon, Ph.D. - Publications

Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Functions of molecular chaperones in modulating cell surface receptors and secreted proteins

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen O, Beng Yeap B, Flicker L, Barzilai N, Atzmon G, ... ... Argon Y, et al. A human variant of Glucose-regulated protein 94 that inefficiently supports IGF production. Endocrinology. en20152058. PMID 26982636 DOI: 10.1210/En.2015-2058  1
2015 Eletto D, Eletto D, Boyle S, Argon Y. PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26487694 DOI: 10.1096/Fj.15-275883  1
2015 Shin S, Argon Y. Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria. Immunity. 43: 409-11. PMID 26377891 DOI: 10.1016/J.Immuni.2015.08.027  1
2015 Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG. Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9088-105. PMID 26085633 DOI: 10.1523/Jneurosci.5032-13.2015  1
2015 Peng M, Ostrovsky J, Kwon YJ, Polyak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser DL, Argon Y, Falk MJ. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Human Molecular Genetics. PMID 26041819 DOI: 10.1093/Hmg/Ddv207  1
2015 Argon Y, Gidalevitz T. Candidate genes that affect aging through protein homeostasis. Advances in Experimental Medicine and Biology. 847: 45-72. PMID 25916585 DOI: 10.1007/978-1-4939-2404-2_2  1
2014 Eletto D, Chevet E, Argon Y, Appenzeller-Herzog C. Redox controls UPR to control redox. Journal of Cell Science. 127: 3649-58. PMID 25107370 DOI: 10.1242/Jcs.153643  1
2014 Dersh D, Jones SM, Eletto D, Christianson JC, Argon Y. OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Molecular Biology of the Cell. 25: 2220-34. PMID 24899641 DOI: 10.1091/Mbc.E14-03-0805  1
2014 Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y. Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association. Molecular Cell. 53: 562-76. PMID 24508390 DOI: 10.1016/J.Molcel.2014.01.004  1
2013 Gidalevitz T, Stevens F, Argon Y. Orchestration of secretory protein folding by ER chaperones. Biochimica Et Biophysica Acta. 1833: 2410-24. PMID 23507200 DOI: 10.1016/J.Bbamcr.2013.03.007  1
2012 Eletto D, Maganty A, Eletto D, Dersh D, Makarewich C, Biswas C, Paton JC, Paton AW, Doroudgar S, Glembotski CC, Argon Y. Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of Cell Science. 125: 4865-75. PMID 22854046 DOI: 10.1242/jcs.108928  1
2012 Barton ER, Park S, James JK, Makarewich CA, Philippou A, Eletto D, Lei H, Brisson B, Ostrovsky O, Li Z, Argon Y. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3691-702. PMID 22649033 DOI: 10.1096/Fj.11-203026  1
2012 Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS. Development of a Grp94 inhibitor. Journal of the American Chemical Society. 134: 9796-804. PMID 22642269 DOI: 10.1021/Ja303477G  1
2012 Marzec M, Eletto D, Argon Y. GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochimica Et Biophysica Acta. 1823: 774-87. PMID 22079671 DOI: 10.1016/J.Bbamcr.2011.10.013  1
2011 Huang Y, Biswas C, Klos Dehring DA, Sriram U, Williamson EK, Li S, Clarke F, Gallucci S, Argon Y, Burkhardt JK. The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 5952-63. PMID 22031761 DOI: 10.4049/Jimmunol.1100870  1
2011 Dehring DA, Clarke F, Ricart BG, Huang Y, Gomez TS, Williamson EK, Hammer DA, Billadeau DD, Argon Y, Burkhardt JK. Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 4805-18. PMID 21398607 DOI: 10.4049/Jimmunol.1003102  1
2010 Eletto D, Dersh D, Argon Y. GRP94 in ER quality control and stress responses. Seminars in Cell & Developmental Biology. 21: 479-85. PMID 20223290 DOI: 10.1016/J.Semcdb.2010.03.004  1
2010 Ostrovsky O, Eletto D, Makarewich C, Barton ER, Argon Y. Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors. Biochimica Et Biophysica Acta. 1803: 333-41. PMID 19914304 DOI: 10.1016/J.Bbamcr.2009.11.005  1
2009 Ostrovsky O, Makarewich CA, Snapp EL, Argon Y. An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 11600-5. PMID 19553200 DOI: 10.1073/Pnas.0902626106  1
2009 Ostrovsky O, Ahmed NT, Argon Y. The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation. Molecular Biology of the Cell. 20: 1855-64. PMID 19158397 DOI: 10.1091/Mbc.E08-04-0346  1
2008 Elkabetz Y, Ofir A, Argon Y, Bar-Nun S. Alternative pathways of disulfide bond formation yield secretion-competent, stable and functional immunoglobulins. Molecular Immunology. 46: 97-105. PMID 18692901 DOI: 10.1016/J.Molimm.2008.07.005  1
2008 Maruvada R, Argon Y, Prasadarao NV. Escherichia coli interaction with human brain microvascular endothelial cells induces signal transducer and activator of transcription 3 association with the C-terminal domain of Ec-gp96, the outer membrane protein A receptor for invasion. Cellular Microbiology. 10: 2326-38. PMID 18662321 DOI: 10.1111/J.1462-5822.2008.01214.X  1
2007 Sriram U, Biswas C, Behrens EM, Dinnall JA, Shivers DK, Monestier M, Argon Y, Gallucci S. IL-4 suppresses dendritic cell response to type I interferons. Journal of Immunology (Baltimore, Md. : 1950). 179: 6446-55. PMID 17982033 DOI: 10.4049/Jimmunol.179.10.6446  1
2007 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Molecular Biology of the Cell. 18: 3764-75. PMID 17634284 DOI: 10.1091/Mbc.E07-03-0275  1
2007 Biswas C, Ostrovsky O, Makarewich CA, Wanderling S, Gidalevitz T, Argon Y. The peptide-binding activity of GRP94 is regulated by calcium. The Biochemical Journal. 405: 233-41. PMID 17411420 DOI: 10.1042/Bj20061867  1
2006 Biswas C, Sriram U, Ciric B, Ostrovsky O, Gallucci S, Argon Y. The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells. International Immunology. 18: 1147-57. PMID 16772370 DOI: 10.1093/Intimm/Dxl049  1
2005 Elkabetz Y, Argon Y, Bar-Nun S. Cysteines in CH1 underlie retention of unassembled Ig heavy chains. The Journal of Biological Chemistry. 280: 14402-12. PMID 15705573 DOI: 10.1074/Jbc.M500161200  1
2004 Gidalevitz T, Biswas C, Ding H, Schneidman-Duhovny D, Wolfson HJ, Stevens F, Radford S, Argon Y. Identification of the N-terminal peptide binding site of glucose-regulated protein 94. The Journal of Biological Chemistry. 279: 16543-52. PMID 14754890 DOI: 10.1074/Jbc.M313060200  1
2002 Vogen S, Gidalevitz T, Biswas C, Simen BB, Stein E, Gulmen F, Argon Y. Radicicol-sensitive peptide binding to the N-terminal portion of GRP94. The Journal of Biological Chemistry. 277: 40742-50. PMID 12189140 DOI: 10.1074/Jbc.M205323200  1
2001 Davis DP, Gallo G, Vogen SM, Dul JL, Sciarretta KL, Kumar A, Raffen R, Stevens FJ, Argon Y. Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain. Journal of Molecular Biology. 313: 1021-34. PMID 11700059 DOI: 10.1006/Jmbi.2001.5092  1
2001 Dul JL, Davis DP, Williamson EK, Stevens FJ, Argon Y. Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains. The Journal of Cell Biology. 152: 705-16. PMID 11266462 DOI: 10.1083/Jcb.152.4.705  1
2000 Davis PD, Raffen R, Dul LJ, Vogen MS, Williamson KE, Stevens JF, Argon Y. Inhibition of amyloid fiber assembly by both BiP and its target peptide. Immunity. 13: 433-42. PMID 11070162 DOI: 10.1016/S1074-7613(00)00043-1  1
1999 Argon Y, Simen BB. GRP94, an ER chaperone with protein and peptide binding properties. Seminars in Cell & Developmental Biology. 10: 495-505. PMID 10597632 DOI: 10.1006/Scdb.1999.0320  1
1999 Stevens FJ, Argon Y. Protein folding in the ER. Seminars in Cell & Developmental Biology. 10: 443-54. PMID 10597627 DOI: 10.1006/Scdb.1999.0315  1
1999 Stevens FJ, Argon Y. Pathogenic light chains and the B-cell repertoire. Immunology Today. 20: 451-7. PMID 10500292 DOI: 10.1016/S0167-5699(99)01502-9  1
1999 Davis DP, Khurana R, Meredith S, Stevens FJ, Argon Y. Mapping the major interaction between binding protein and Ig light chains to sites within the variable domain. Journal of Immunology (Baltimore, Md. : 1950). 163: 3842-50. PMID 10490983  1
1999 Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Molecular Endocrinology (Baltimore, Md.). 13: 1435-48. PMID 10478836 DOI: 10.1210/Mend.13.9.0339  1
1999 Mårtensson A, Argon Y, Melchers F, Dul JL, Mårtensson IL. Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice. International Immunology. 11: 453-60. PMID 10221657 DOI: 10.1093/Intimm/11.3.453  1
1998 Bass J, Chiu G, Argon Y, Steiner DF. Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization. The Journal of Cell Biology. 141: 637-46. PMID 9566965 DOI: 10.1083/Jcb.141.3.637  1
1997 Lindesmith L, McIlvain JM, Argon Y, Sheetz MP. Phosphotransferases associated with the regulation of kinesin motor activity. The Journal of Biological Chemistry. 272: 22929-33. PMID 9312551 DOI: 10.1074/Jbc.272.36.22929  1
1996 Dul JL, Aviel S, Melnick J, Argon Y. Ig light chains are secreted predominantly as monomers. Journal of Immunology (Baltimore, Md. : 1950). 157: 2969-75. PMID 8816404  1
1996 Hendershot L, Wei J, Gaut J, Melnick J, Aviel S, Argon Y. Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants. Proceedings of the National Academy of Sciences of the United States of America. 93: 5269-74. PMID 8643565 DOI: 10.1073/Pnas.93.11.5269  1
1996 Dul JL, Argon Y, Winkler T, ten Boekel E, Melchers F, Mårtensson IL. The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development. European Journal of Immunology. 26: 906-13. PMID 8625987 DOI: 10.1002/Eji.1830260428  1
1995 Melnick J, Argon Y. Molecular chaperones and the biosynthesis of antigen receptors. Immunology Today. 16: 243-50. PMID 7779255 DOI: 10.1016/0167-5699(95)80167-7  1
1995 Griffiths GM, Argon Y. Structure and biogenesis of lytic granules. Current Topics in Microbiology and Immunology. 198: 39-58. PMID 7774282  1
1994 McIlvain JM, Burkhardt JK, Hamm-Alvarez S, Argon Y, Sheetz MP. Regulation of kinesin activity by phosphorylation of kinesin-associated proteins. The Journal of Biological Chemistry. 269: 19176-82. PMID 8034676  1
1994 Melnick J, Dul JL, Argon Y. Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature. 370: 373-5. PMID 7913987 DOI: 10.1038/370373A0  1
1994 Bast RC, Xu F, Yu Y, Crews J, Argon Y, Maier L, Lidor Y, Berchuck A, Boyer CM. Additive and synergistic interactions of monoclonal antibodies and immunotoxins reactive with breast and ovarian cancer. Immunology Series. 61: 23-30. PMID 7912111  1
1993 Burkhardt JK, McIlvain JM, Sheetz MP, Argon Y. Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro. Journal of Cell Science. 104: 151-62. PMID 8449993  1
1993 Gardner AM, Aviel S, Argon Y. Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment. The Journal of Biological Chemistry. 268: 25940-7. PMID 8245027  1
1993 Burkhardt JK, Wiebel FA, Hester S, Argon Y. The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes. The Journal of Experimental Medicine. 178: 1845-56. PMID 7902407 DOI: 10.1084/Jem.178.6.1845  1
1992 Dul JL, Burrone OR, Argon Y. A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine. Journal of Immunology (Baltimore, Md. : 1950). 149: 1927-33. PMID 1517562  1
1992 Melnick J, Aviel S, Argon Y. The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. The Journal of Biological Chemistry. 267: 21303-6. PMID 1400441  1
1992 Crews JR, Maier LA, Yu YH, Hester S, O'Briant K, Leslie DS, DeSombre K, George SL, Boyer CM, Argon Y. A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. International Journal of Cancer. Journal International Du Cancer. 51: 772-9. PMID 1351885 DOI: 10.1002/Ijc.2910510518  1
1991 Maier LA, Xu FJ, Hester S, Boyer CM, McKenzie S, Bruskin AM, Argon Y, Bast RC. Requirements for the internalization of a murine monoclonal antibody directed against the HER-2/neu gene product c-erbB-2. Cancer Research. 51: 5361-9. PMID 1680547  1
1990 Wiest DL, Burkhardt JK, Hester S, Hortsch M, Meyer DI, Argon Y. Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. The Journal of Cell Biology. 110: 1501-11. PMID 2335560 DOI: 10.1083/Jcb.110.5.1501  1
1990 Burkhardt JK, Hester S, Lapham CK, Argon Y. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. The Journal of Cell Biology. 111: 2327-40. PMID 2277062 DOI: 10.1083/Jcb.111.6.2327  1
1990 Dul JL, Argon Y. A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 87: 8135-9. PMID 2122454 DOI: 10.1073/Pnas.87.20.8135  1
1989 Argon Y, Burkhardt JK, Leeds JM, Milstein C. Two steps in the intracellular transport of IgD are sensitive to energy depletion. Journal of Immunology (Baltimore, Md. : 1950). 142: 554-61. PMID 2911010  1
1989 Burkhardt JK, Hester S, Argon Y. Two proteins targeted to the same lytic granule compartment undergo very different posttranslational processing. Proceedings of the National Academy of Sciences of the United States of America. 86: 7128-32. PMID 2674947 DOI: 10.1073/Pnas.86.18.7128  1
1989 Burkhardt JK, Hester S, Argon Y. The glycoprotein of VSV accumulates in a distal Golgi compartment in the presence of CCCP. Journal of Cell Science. 92: 643-54. PMID 2557360  1
1989 Burkhardt JK, Argon Y. Intracellular transport of the glycoprotein of VSV is inhibited by CCCP at a late stage of post-translational processing. Journal of Cell Science. 92: 633-42. PMID 2557359  1
1989 Wiest DL, Burkhardt JK, Stockdale AM, Argon Y. Expression of intracisternal A-type particles is increased when a B-cell lymphoma differentiates into an immunoglobulin-secreting cell. Journal of Virology. 63: 659-68. PMID 2492059 DOI: 10.1128/Jvi.63.2.659-668.1989  1
1988 McKinnon KP, Dunlevy JR, Dawson JR, Argon Y. Cell-mediated cytotoxicity and the reorientation of effector cell granules towards the target cell are inhibited by the protonophore carbonylcyanide m-chlorophenylhydrazone. Human Immunology. 22: 81-95. PMID 3262100 DOI: 10.1016/0198-8859(88)90039-0  1
1987 Stockdale AM, Dul JL, Wiest DL, Digel M, Argon Y. The expression of membrane and secreted immunoglobulin during the in vitro differentiation of the murine B cell lymphoma CH12. Journal of Immunology (Baltimore, Md. : 1950). 139: 3527-35. PMID 3500220  1
1984 Argon Y, Milstein C. Intracellular processing of membrane and secreted immunoglobulin delta-chains. Journal of Immunology (Baltimore, Md. : 1950). 133: 1627-34. PMID 6431004  1
1983 Argon Y, Burrone OR, Milstein C. Molecular characterization of a nonsecreting myeloma mutant. European Journal of Immunology. 13: 301-5. PMID 6406235 DOI: 10.1002/Eji.1830130406  1
1982 Ward S, Roberts TM, Nelson GA, Argon Y. The Development and Motility of Caenorhabditis elegans Spermatozoa. Journal of Nematology. 14: 259-66. PMID 19295707  1
1981 Ward S, Argon Y, Nelson GA. Sperm morphogenesis in wild-type and fertilization-defective mutants of Caenorhabditis elegans. The Journal of Cell Biology. 91: 26-44. PMID 7298721 DOI: 10.1083/Jcb.91.1.26  1
1980 Carbonetto S, Argon Y. Lectins induce the redistribution and internalization of receptors on the surface of cultured neurons. Developmental Biology. 80: 364-78. PMID 7450287 DOI: 10.1016/0012-1606(80)90411-X  1
1980 Argon Y, Ward S. Caenorhabditis elegans fertilization-defective mutants with abnormal sperm. Genetics. 96: 413-33. PMID 7196361  1
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