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Jason Micklefield, PhD - Publications

Manchester Institute of Biotechnology University of Manchester, Manchester, England, United Kingdom 
Nucleic Acid Redesign and Recognition, Biocatalysis and Enzyme Mechanism, Biosynthesis and Biosynthetic Engineering

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gomez-Escribano JP, Algora Gallardo L, Bozhüyük KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B. Genome editing reveals that pSCL4 is required for chromosome linearity in . Microbial Genomics. 7. PMID 34747689 DOI: 10.1099/mgen.0.000669  0.687
2020 Dunstan MS, Robinson CJ, Jervis AJ, Yan C, Carbonell P, Hollywood KA, Currin A, Swainston N, Feuvre RL, Micklefield J, Faulon JL, Breitling R, Turner N, Takano E, Scrutton NS. Engineering towards production of gatekeeper (2)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol. Synthetic Biology (Oxford, England). 5: ysaa012. PMID 33195815 DOI: 10.1093/Synbio/Ysaa012  0.318
2020 Herbert AJ, Shepherd SA, Cronin VA, Bennett MR, Sung R, Micklefield J. Engineering orthogonal methyltransferases to create alternative bioalkylation pathways. Angewandte Chemie (International Ed. in English). PMID 32402113 DOI: 10.1002/Anie.202004963  0.371
2020 Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Swainston N, Spiess R, Taylor S, Mulherin P, Parker S, Rowe W, Matthews NE, Malone KJ, ... ... Micklefield J, et al. Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers. Metabolic Engineering. PMID 32335188 DOI: 10.1016/J.Ymben.2020.04.008  0.336
2020 Winn M, Richardson SM, Campopiano DJ, Micklefield J. Harnessing and engineering amide bond forming ligases for the synthesis of amides. Current Opinion in Chemical Biology. 55: 77-85. PMID 32058241 DOI: 10.1016/J.Cbpa.2019.12.004  0.364
2019 Bozhüyük KA, Micklefield J, Wilkinson B. Engineering enzymatic assembly lines to produce new antibiotics. Current Opinion in Microbiology. 51: 88-96. PMID 31743841 DOI: 10.1016/J.Mib.2019.10.007  0.728
2019 Cummings M, Peters AD, Whitehead GFS, Menon BRK, Micklefield J, Webb SJ, Takano E. Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. Plos Biology. 17: e3000347. PMID 31318855 DOI: 10.1371/Journal.Pbio.3000347  0.349
2018 Bennett M, Thompson M, Shepherd S, Dunstan M, Herbert A, Smith D, Cronin V, Menon B, Levy C, Micklefield J. Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase. Angewandte Chemie (International Ed. in English). PMID 29791083 DOI: 10.1002/Anie.201805060  0.347
2018 de Mattos-Shipley KMJ, Greco C, Heard DM, Hough G, Mulholland NP, Vincent JL, Micklefield J, Simpson TJ, Willis CL, Cox RJ, Bailey AM. The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chemical Science. 9: 4109-4117. PMID 29780540 DOI: 10.1039/C8Sc00717A  0.419
2018 Winn M, Francis D, Micklefield J. De novo Biosynthesis of 'Non-Natural' Thaxtomin Phytotoxins. Angewandte Chemie (International Ed. in English). PMID 29603527 DOI: 10.1002/Anie.201801525  0.387
2017 Fisk H, Xu Y, Westley C, Turner NJ, Micklefield J, Goodacre R. From multi-step enzyme monitoring to whole-cell biotransformations: development of real-time UVRR spectroscopy. Analytical Chemistry. PMID 29076721 DOI: 10.1021/Acs.Analchem.7B03742  0.323
2017 Menon B, Brandenburger E, Sharif H, Klemstein U, Shepherd S, Greaney M, Micklefield J. RadH a Versatile Halogenase for Integration into Synthetic Pathways. Angewandte Chemie (International Ed. in English). PMID 28722773 DOI: 10.1002/Anie.201706342  0.405
2017 Latham J, Brandenburger E, Shepherd SA, Menon BRK, Micklefield J. Development of Halogenase Enzymes for Use in Synthesis. Chemical Reviews. PMID 28466644 DOI: 10.1021/Acs.Chemrev.7B00032  0.368
2017 Westley C, Fisk H, Xu Y, Hollywood K, Carnell A, Micklefield J, Turner N, Goodacre R. Real-time monitoring of enzyme-catalysed reactions using deep UV resonance Raman spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28370547 DOI: 10.1002/Chem.201701388  0.301
2017 Bennett MR, Shepherd SA, Cronin VA, Micklefield J. Recent advances in methyltransferase biocatalysis. Current Opinion in Chemical Biology. 37: 97-106. PMID 28259085 DOI: 10.1016/J.Cbpa.2017.01.020  0.365
2016 Menon BR, Latham J, Dunstan MS, Brandenburger E, Klemstein U, Leys D, Karthikeyan C, Greaney MF, Shepherd SA, Micklefield J. Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic & Biomolecular Chemistry. 14: 9354-9361. PMID 27714222 DOI: 10.1039/C6Ob01861K  0.343
2016 Robinson CJ, Medina-Stacey D, Wu MC, Vincent HA, Micklefield J. Rewiring Riboswitches to Create New Genetic Circuits in Bacteria. Methods in Enzymology. 575: 319-48. PMID 27417935 DOI: 10.1016/Bs.Mie.2016.02.022  0.357
2016 Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, ... ... Micklefield J, et al. SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. Biochemical Society Transactions. 44: 675-7. PMID 27284023 DOI: 10.1042/Bst20160009  0.332
2016 Struck AW, Bennett MR, Shepherd SA, Law BJ, Zhou Y, Wong LS, Micklefield J. An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins. Journal of the American Chemical Society. PMID 26867114 DOI: 10.1021/Jacs.5B10928  0.364
2016 Shepherd SA, Menon BR, Fisk H, Struck AW, Levy C, Leys D, Micklefield J. A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase Enzyme. Chembiochem : a European Journal of Chemical Biology. PMID 26840773 DOI: 10.1002/Cbic.201600051  0.337
2016 Law BJ, Bennett MR, Thompson ML, Levy C, Shepherd SA, Leys D, Micklefield J. Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase. Angewandte Chemie (International Ed. in English). PMID 26797714 DOI: 10.1002/Anie.201508287  0.316
2016 Winn M, Fyans JK, Zhuo Y, Micklefield J. Recent advances in engineering nonribosomal peptide assembly lines Natural Product Reports. 33: 317-347. DOI: 10.1039/C5Np00099H  0.373
2015 Shepherd SA, Karthikeyan C, Latham J, Struck AW, Thompson ML, Menon BRK, Styles MQ, Levy C, Leys D, Micklefield J. Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. Chemical Science. 6: 3454-3460. PMID 29511510 DOI: 10.1039/C5Sc00913H  0.378
2015 Law BJC, Struck AW, Bennett MR, Wilkinson B, Micklefield J. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase. Chemical Science. 6: 2885-2892. PMID 29403635 DOI: 10.1039/C5Sc00164A  0.732
2015 Morra R, Shankar J, Robinson CJ, Halliwell S, Butler L, Upton M, Hay S, Micklefield J, Dixon N. Dual transcriptional-translational cascade permits cellular level tuneable expression control. Nucleic Acids Research. PMID 26405200 DOI: 10.1093/Nar/Gkv912  0.555
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Micklefield J, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.715
2015 Wu MC, Lowe PT, Robinson CJ, Vincent HA, Dixon N, Leigh J, Micklefield J. Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch. Journal of the American Chemical Society. PMID 26106809 DOI: 10.1021/Jacs.5B03405  0.576
2015 Wu MC, Styles MQ, Law BJ, Struck AW, Nunns L, Micklefield J. Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29. Microbiology (Reading, England). PMID 25878261 DOI: 10.1099/Mic.0.000095  0.427
2015 Lewin R, Goodall M, Thompson ML, Leigh J, Breuer M, Baldenius K, Micklefield J. Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 6557-63. PMID 25766433 DOI: 10.1002/Chem.201406014  0.375
2015 Diez V, Loznik M, Taylor S, Winn M, Rattray NJ, Podmore H, Micklefield J, Goodacre R, Medema MH, Müller U, Bovenberg R, Janssen DB, Takano E. Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. Acs Synthetic Biology. 4: 796-807. PMID 25713978 DOI: 10.1021/Sb500368W  0.393
2014 Robinson CJ, Vincent HA, Wu MC, Lowe PT, Dunstan MS, Leys D, Micklefield J. Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species. Journal of the American Chemical Society. 136: 10615-24. PMID 24971878 DOI: 10.1021/Ja502873J  0.364
2014 Vincent HA, Robinson CJ, Wu MC, Dixon N, Micklefield J. Generation of orthogonally selective bacterial riboswitches by targeted mutagenesis and in vivo screening. Methods in Molecular Biology (Clifton, N.J.). 1111: 107-29. PMID 24549615 DOI: 10.1007/978-1-62703-755-6_8  0.579
2012 Struck AW, Thompson ML, Wong LS, Micklefield J. S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications. Chembiochem : a European Journal of Chemical Biology. 13: 2642-55. PMID 23180741 DOI: 10.1002/Cbic.201200556  0.364
2012 Thirlway J, Lewis R, Nunns L, Al Nakeeb M, Styles M, Struck AW, Smith CP, Micklefield J. Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity. Angewandte Chemie (International Ed. in English). 51: 7181-4. PMID 22711659 DOI: 10.1002/Anie.201202043  0.367
2012 Chen L, Cressina E, Dixon N, Erixon K, Agyei-Owusu K, Micklefield J, Smith AG, Abell C, Leeper FJ. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. Organic & Biomolecular Chemistry. 10: 5924-31. PMID 22514012 DOI: 10.1039/C2Ob07116A  0.533
2012 Wu MC, Law B, Wilkinson B, Micklefield J. Bioengineering natural product biosynthetic pathways for therapeutic applications. Current Opinion in Biotechnology. 23: 931-40. PMID 22487048 DOI: 10.1016/J.Copbio.2012.03.008  0.744
2012 Dixon N, Robinson CJ, Geerlings T, Duncan JN, Drummond SP, Micklefield J. Orthogonal riboswitches for tuneable coexpression in bacteria. Angewandte Chemie (International Ed. in English). 51: 3620-4. PMID 22383398 DOI: 10.1002/Anie.201109106  0.55
2011 Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science (Royal Society of Chemistry : 2010). 2011: 273-278. PMID 22822423 DOI: 10.1039/C0Sc00297F  0.732
2011 Worthington RJ, Micklefield J. Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14429-41. PMID 22076794 DOI: 10.1002/Chem.201101950  0.334
2011 Lewis RA, Nunns L, Thirlway J, Carroll K, Smith CP, Micklefield J. Active site modification of the β-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides. Chemical Communications (Cambridge, England). 47: 1860-2. PMID 21135931 DOI: 10.1039/C0Cc03444D  0.355
2011 Dixon N, Robinson CJ, Duncan JN, Geerlings T, Lestari SA, Micklefield J. Orthogonal riboswitches as tools for controlling gene expression in bacteria Collection of Czechoslovak Chemical Communications. 12: 86-94. DOI: 10.1135/Css201112086  0.531
2010 Dixon N, Duncan JN, Geerlings T, Dunstan MS, McCarthy JE, Leys D, Micklefield J. Reengineering orthogonally selective riboswitches. Proceedings of the National Academy of Sciences of the United States of America. 107: 2830-5. PMID 20133756 DOI: 10.1073/Pnas.0911209107  0.561
2010 MICKLEFIELD J, BLOCK MH, BATTERSBY AR. ChemInform Abstract: Alkylation and Acylation of 5-Phenylsulfonyl- and 5-Cyanobutyrolactones. Cheminform. 24: no-no. DOI: 10.1002/chin.199301167  0.41
2009 Wong LS, Khan F, Micklefield J. Selective covalent protein immobilization: strategies and applications. Chemical Reviews. 109: 4025-53. PMID 19572643 DOI: 10.1021/Cr8004668  0.335
2009 Wilkinson B, Micklefield J. Chapter 14. Biosynthesis of nonribosomal peptide precursors. Methods in Enzymology. 458: 353-78. PMID 19374990 DOI: 10.1016/S0076-6879(09)04814-9  0.733
2009 Micklefield J. Biosynthesis and biosynthetic engineering of calcium-dependent lipopeptide antibiotics Pure and Applied Chemistry. 81: 1065-1074. DOI: 10.1351/Pac-Con-08-08-29  0.423
2008 Wong LS, Thirlway J, Micklefield J. Direct site-selective covalent protein immobilization catalyzed by a phosphopantetheinyl transferase. Journal of the American Chemical Society. 130: 12456-64. PMID 18722432 DOI: 10.1021/Ja8030278  0.307
2008 Amir-Heidari B, Thirlway J, Micklefield J. Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues. Organic & Biomolecular Chemistry. 6: 975-8. PMID 18327318 DOI: 10.1039/B718766C  0.366
2007 Dixon N, Wong LS, Geerlings TH, Micklefield J. Cellular targets of natural products. Natural Product Reports. 24: 1288-310. PMID 18033580 DOI: 10.1039/B616808F  0.578
2007 Powell A, Borg M, Amir-Heidari B, Neary JM, Thirlway J, Wilkinson B, Smith CP, Micklefield J. Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains. Journal of the American Chemical Society. 129: 15182-91. PMID 18020333 DOI: 10.1021/Ja074331O  0.741
2007 Mahlert C, Kopp F, Thirlway J, Micklefield J, Marahiel MA. Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. Journal of the American Chemical Society. 129: 12011-8. PMID 17784761 DOI: 10.1021/Ja074427I  0.371
2007 Powell A, Al Nakeeb M, Wilkinson B, Micklefield J. Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. Chemical Communications (Cambridge, England). 2683-5. PMID 17594019 DOI: 10.1039/B706224A  0.71
2007 Wilkinson B, Micklefield J. Mining and engineering natural-product biosynthetic pathways. Nature Chemical Biology. 3: 379-86. PMID 17576425 DOI: 10.1038/Nchembio.2007.7  0.753
2007 Neary JM, Powell A, Gordon L, Milne C, Flett F, Wilkinson B, Smith CP, Micklefield J. An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics. Microbiology (Reading, England). 153: 768-76. PMID 17322197 DOI: 10.1099/Mic.0.2006/002725-0  0.748
2007 Tan TH, Worthington RJ, Pritchard RG, Morral J, Micklefield J. Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. Organic & Biomolecular Chemistry. 5: 239-48. PMID 17205167 DOI: 10.1039/B613384N  0.341
2006 Milne C, Powell A, Jim J, Al Nakeeb M, Smith CP, Micklefield J. Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides. Journal of the American Chemical Society. 128: 11250-9. PMID 16925444 DOI: 10.1021/Ja062960C  0.334
2005 Micklefield J. Nature's protection racket. Chemistry & Biology. 12: 611-3. PMID 15975504 DOI: 10.1016/J.Chembiol.2005.06.002  0.313
2004 Uguru GC, Milne C, Borg M, Flett F, Smith CP, Micklefield J. Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates. Journal of the American Chemical Society. 126: 5032-3. PMID 15099062 DOI: 10.1021/Ja048778Y  0.308
2002 Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J. Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chemistry & Biology. 9: 1175-87. PMID 12445768 DOI: 10.1016/S1074-5521(02)00252-1  0.751
2001 Micklefield J. Backbone modification of nucleic acids: synthesis, structure and therapeutic applications. Current Medicinal Chemistry. 8: 1157-79. PMID 11472234 DOI: 10.2174/0929867013372391  0.341
1997 Micklefield J, Beckmann M, Mackman RL, Block MH, Leeper FJ, Battersby AR. Haem d1: Stereoselective synthesis of the macrocycle to establish its absolute configuration as 2R,7R Journal of the Chemical Society - Perkin Transactions 1. 2123-2138. DOI: 10.1039/A700655A  0.483
1997 Mackman RL, Micklefield J, Block MH, Leeper FJ, Battersby AR. Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins Journal of the Chemical Society - Perkin Transactions 1. 2111-2122. DOI: 10.1039/A700654C  0.516
1995 Micklefield J, Harris KJ, Gröger S, Mocek U, Hilbi H, Dimroth P, Floss HG. Stereochemical course of malonate decarboxylation in Malonomonas rubra Journal of the American Chemical Society. 117: 1153-1154. DOI: 10.1021/Ja00108A042  0.445
1993 Micklefield J, MacKman RL, Aucken CJ, Beckmann M, Block MH, Leeper FJ, Battersby AR. A novel stereoselective synthesis of the macrocycle of haem d1 that establishes its absolute configuration as 2R,7R Journal of the Chemical Society, Chemical Communications. 275-277. DOI: 10.1039/C39930000275  0.466
1992 Micklefield J, Block MH, Battersby AR. Alkylation and acylation of 5-phenylsulphonyl- and 5-cyanobutyrolactones Tetrahedron. 48: 7519-7526. DOI: 10.1016/S0040-4020(01)90365-5  0.485
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