Perry A. Frey - Publications

Affiliations: 
Biochemistry University of Wisconsin, Madison, Madison, WI 
Area:
Mechanisms of enzyme and coenzyme action; stereochemistry and mechanisms of phospho- and nucleotidyl transferase action; structure and function of multienzyme complexes
Website:
http://www.biochem.wisc.edu/faculty/frey/

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Ngo PD, Mansoorabadi SO, Frey PA. Serine Protease Catalysis: A Computational Study of Tetrahedral Intermediates and Inhibitory Adducts. The Journal of Physical Chemistry. B. PMID 27387593 DOI: 10.1021/acs.jpcb.6b04089  1
2014 Frey PA. Travels with carbon-centered radicals. 5'-deoxyadenosine and 5'-deoxyadenosine-5'-yl in radical enzymology. Accounts of Chemical Research. 47: 540-9. PMID 24308628 DOI: 10.1021/ar400194k  1
2013 Frey PA, Hegeman AD. Chemical and stereochemical actions of UDP-galactose 4-epimerase. Accounts of Chemical Research. 46: 1417-26. PMID 23339688 DOI: 10.1021/Ar300246K  1
2013 Chen YH, Maity AN, Frey PA, Ke SC. Mechanism-based inhibition reveals transitions between two conformational states in the action of lysine 5,6-aminomutase: a combination of electron paramagnetic resonance spectroscopy, electron nuclear double resonance spectroscopy, and density functional theory study. Journal of the American Chemical Society. 135: 788-94. PMID 23231091 DOI: 10.1021/Ja309603A  1
2012 Frey PA, Reed GH. The ubiquity of iron. Acs Chemical Biology. 7: 1477-81. PMID 22845493 DOI: 10.1021/Cb300323Q  1
2011 Chen YH, Maity AN, Pan YC, Frey PA, Ke SC. Radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase: role of tyrosine-263α as revealed by electron paramagnetic resonance spectroscopy. Journal of the American Chemical Society. 133: 17152-5. PMID 21939264 DOI: 10.1021/Ja207766C  1
2011 Frey PA, Reed GH. Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases. Biochimica Et Biophysica Acta. 1814: 1548-57. PMID 21435400 DOI: 10.1016/J.Bbapap.2011.03.005  1
2011 Frey PA, Outten CE. Forging ahead: new mechanistic insights into iron biochemistry. Current Opinion in Chemical Biology. 15: 257-9. PMID 21411359 DOI: 10.1016/J.Cbpa.2011.02.022  1
2010 Ruzicka FJ, Frey PA. Kinetic and spectroscopic evidence of negative cooperativity in the action of lysine 2,3-aminomutase. The Journal of Physical Chemistry. B. 114: 16118-24. PMID 20608698 DOI: 10.1021/Jp103856M  1
2010 Frey PA. Sulfur as a mechanistic probe in enzymatic and non-enzymatic substitution at phosphorus New Journal of Chemistry. 34: 820-828. DOI: 10.1039/B9Nj00619B  1
2010 Frey PA. Cobalamin coenzymes in enzymology Comprehensive Natural Products Ii: Chemistry and Biology. 7: 501-546.  1
2009 Maity AN, Hsieh CP, Huang MH, Chen YH, Tang KH, Behshad E, Frey PA, Ke SC. Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase. The Journal of Physical Chemistry. B. 113: 12161-3. PMID 19685884 DOI: 10.1021/Jp905357A  1
2009 Tang KH, Mansoorabadi SO, Reed GH, Frey PA. Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. Biochemistry. 48: 8151-60. PMID 19634897 DOI: 10.1021/Bi900828F  1
2008 Yevenes A, Frey PA. Cloning, expression, purification, cofactor requirements, and steady state kinetics of phosphoketolase-2 from Lactobacillus plantarum. Bioorganic Chemistry. 36: 121-7. PMID 18430452 DOI: 10.1016/j.bioorg.2008.03.002  1
2008 Frey PA, Hegeman AD, Ruzicka FJ. The Radical SAM Superfamily. Critical Reviews in Biochemistry and Molecular Biology. 43: 63-88. PMID 18307109 DOI: 10.1080/10409230701829169  1
2007 Wang SC, Frey PA. Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme. Biochemistry. 46: 12889-95. PMID 17944492 DOI: 10.1021/Bi701745H  1
2007 Schwartz PA, Lobrutto R, Reed GH, Frey PA. Probing interactions from solvent-exchangeable protons and monovalent cations with the 1,2-propanediol-1-yl radical intermediate in the reaction of dioldehydrase. Protein Science : a Publication of the Protein Society. 16: 1157-64. PMID 17525464 DOI: 10.1110/Ps.072768007  1
2007 Schwartz PA, Frey PA. Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin. Biochemistry. 46: 7293-301. PMID 17516630 DOI: 10.1021/Bi700078Z  1
2007 Schwartz PA, Frey PA. 5'-Peroxyadenosine and 5'-peroxyadenosylcobalamin as intermediates in the aerobic photolysis of adenosylcobalamin. Biochemistry. 46: 7284-92. PMID 17503776 DOI: 10.1021/Bi700077V  1
2007 Wang SC, Frey PA. S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends in Biochemical Sciences. 32: 101-10. PMID 17291766 DOI: 10.1016/j.tibs.2007.01.002  1
2007 Chen D, Tanem J, Frey PA. Basis for the equilibrium constant in the interconversion of l-lysine and l-beta-lysine by lysine 2,3-aminomutase. Biochimica Et Biophysica Acta. 1774: 297-302. PMID 17254853 DOI: 10.1016/j.bbapap.2006.12.002  1
2007 Ruzicka FJ, Frey PA. Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. Biochimica Et Biophysica Acta. 1774: 286-96. PMID 17222594 DOI: 10.1016/j.bbapap.2006.11.008  1
2006 Mansoorabadi SO, Magnusson OT, Poyner RR, Frey PA, Reed GH. Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase. Biochemistry. 45: 14362-70. PMID 17128975 DOI: 10.1021/Bi061586Q  1
2006 Chen D, Frey PA, Lepore BW, Ringe D, Ruzicka FJ. Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase. Biochemistry. 45: 12647-53. PMID 17042481 DOI: 10.1021/Bi061329L  1
2006 Behshad E, Ruzicka FJ, Mansoorabadi SO, Chen D, Reed GH, Frey PA. Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: the case of lysine 2,3-aminomutases. Biochemistry. 45: 12639-46. PMID 17042480 DOI: 10.1021/bi061328t  1
2006 Frey PA, Hegeman AD, Reed GH. Free radical mechanisms in enzymology. Chemical Reviews. 106: 3302-16. PMID 16895329 DOI: 10.1021/Cr050292S  1
2006 Lees NS, Chen D, Walsby CJ, Behshad E, Frey PA, Hoffman BM. How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy. Journal of the American Chemical Society. 128: 10145-54. PMID 16881644 DOI: 10.1021/Ja061282R  1
2006 Frey PA. Snapshots of three intermediates at the active site of pyruvate oxidase. Nature Chemical Biology. 2: 294-5. PMID 16710333 DOI: 10.1038/nchembio0606-294  1
2006 Hinckley GT, Frey PA. Cofactor dependence of reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase. Biochemistry. 45: 3219-25. PMID 16519516 DOI: 10.1021/Bi0519497  1
2006 McCoy JG, Arabshahi A, Bitto E, Bingman CA, Ruzicka FJ, Frey PA, Phillips GN. Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana. Biochemistry. 45: 3154-62. PMID 16519510 DOI: 10.1021/Bi052232M  1
2006 Hinckley GT, Frey PA. An adaptable spectroelectrochemical titrator: the midpoint reduction potential of the iron-sulfur center in lysine 2,3-aminomutase. Analytical Biochemistry. 349: 103-11. PMID 16384547 DOI: 10.1016/J.Ab.2005.11.021  1
2005 Lepore BW, Ruzicka FJ, Frey PA, Ringe D. The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proceedings of the National Academy of Sciences of the United States of America. 102: 13819-24. PMID 16166264 DOI: 10.1073/Pnas.0505726102  1
2005 Huang K, Arabshahi A, Frey PA. pH-dependence in the hydrolytic action of the human fragile histidine triad European Journal of Organic Chemistry. 5198-5206. DOI: 10.1002/ejoc.200500499  1
2004 Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE. Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. Biochemistry. 43: 13883-91. PMID 15518536 DOI: 10.1021/Bi048207I  1
2004 Berkovitch F, Behshad E, Tang KH, Enns EA, Frey PA, Drennan CL. A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proceedings of the National Academy of Sciences of the United States of America. 101: 15870-5. PMID 15514022 DOI: 10.1073/Pnas.0407074101  1
2004 Huang K, Frey PA. Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. Journal of the American Chemical Society. 126: 9548-9. PMID 15291552 DOI: 10.1021/Ja0400640  1
2004 Huang K, Arabshahi A, Wei Y, Frey PA. The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit. Biochemistry. 43: 7637-42. PMID 15182206 DOI: 10.1021/Bi049762N  1
2004 Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE. Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida. Acta Crystallographica. Section D, Biological Crystallography. 60: 941-4. PMID 15103146 DOI: 10.1107/S0907444904005256  1
2004 Frey PA. Strong hydrogen bonding in chymotrypsin and other serine proteases Journal of Physical Organic Chemistry. 17: 511-520.  1
2003 Chen D, Walsby C, Hoffman BM, Frey PA. Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase. Journal of the American Chemical Society. 125: 11788-9. PMID 14505379 DOI: 10.1021/Ja036120Z  1
2003 Tang KH, Casarez AD, Wu W, Frey PA. Kinetic and biochemical analysis of the mechanism of action of lysine 5,6-aminomutase. Archives of Biochemistry and Biophysics. 418: 49-54. PMID 13679082 DOI: 10.1016/S0003-9861(03)00346-1  1
2003 Frey PA, Magnusson OT. S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin? Chemical Reviews. 103: 2129-48. PMID 12797826 DOI: 10.1021/Cr020422M  1
2003 Hinckley GT, Ruzicka FJ, Thompson MJ, Blackburn GM, Frey PA. Adenosyl coenzyme and pH dependence of the [4Fe-4S]2+/1+ transition in lysine 2,3-aminomutase. Archives of Biochemistry and Biophysics. 414: 34-9. PMID 12745252 DOI: 10.1016/S0003-9861(03)00160-7  1
2003 Chen D, Abend A, Stubbe J, Frey PA. Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. Biochemistry. 42: 4578-84. PMID 12693955 DOI: 10.1021/Bi030018X  1
2003 Beebe JA, Arabshahi A, Clifton JG, Ringe D, Petsko GA, Frey PA. Galactose mutarotase: pH dependence of enzymatic mutarotation. Biochemistry. 42: 4414-20. PMID 12693937 DOI: 10.1021/Bi020639A  1
2003 Schwart P, LoBrutto R, Reed GH, Frey PA. Suicide Inactivation of Dioldehydrase by 2-Chloroacetaldehyde: Formation of the 'cis-Ethanesemidione' Radical, and the Role of a Monovalent Cation Helvetica Chimica Acta. 86: 3764-3775. DOI: 10.1002/Hlca.200390318  1
2003 Frey PA. Guidelines for writing research papers Biochemistry and Molecular Biology Education. 31: 237-241. DOI: 10.1002/bmb.2003.494031040241  1
2002 Frey PA, Chang CH, Ballinger MD, Reed GH. Kinetic characterization of transient free radical intermediates in reaction of lysine 2,3-aminomutase by EPR lineshape analysis. Methods in Enzymology. 354: 426-35. PMID 12418244 DOI: 10.1016/S0076-6879(02)54033-7  1
2002 Geeganage S, Frey PA. Galactose-1-phosphate uridylyltransferase: kinetics of formation and reaction of uridylyl-enzyme intermediate in wild-type and specifically mutated uridylyltransferases. Methods in Enzymology. 354: 134-48. PMID 12418221 DOI: 10.1016/S0076-6879(02)54010-6  1
2002 Gross JW, Frey PA. Rapid mix-quench MALDI-TOF mass spectrometry for analysis of enzymatic systems. Methods in Enzymology. 354: 27-49. PMID 12418215 DOI: 10.1016/S0076-6879(02)54004-0  1
2002 Tang KH, Harms A, Frey PA. Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. Biochemistry. 41: 8767-76. PMID 12093296 DOI: 10.1021/Bi020255K  1
2002 Westler WM, Frey PA, Lin J, Wemmer DE, Morimoto H, Williams PG, Markley JL. Evidence for a strong hydrogen bond in the catalytic dyad of transition-state analogue inhibitor complexes of chymotrypsin from proton-triton NMR isotope shifts. Journal of the American Chemical Society. 124: 4196-7. PMID 11960433 DOI: 10.1021/Ja017860F  1
2002 Magnusson OT, Frey PA. Facile hydrogen-deuterium exchange at the 5'-position of an analogue of S-adenosyl-l-methionine. Bioorganic Chemistry. 30: 53-61. PMID 11955002 DOI: 10.1006/Bioo.2001.1223  1
2002 Hegeman AD, Gross JW, Frey PA. Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase. Biochemistry. 41: 2797-804. PMID 11851427 DOI: 10.1021/Bi011748C  1
2002 Magnusson OT, Frey PA. Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer. Biochemistry. 41: 1695-702. PMID 11814365 DOI: 10.1021/Bi011947W  1
2002 Frey PA. Characterization of a low barrier hydrogen bond in the active site of chymotrypsin Journal of Molecular Structure. 615: 153-161. DOI: 10.1016/S0022-2860(02)00223-5  1
2002 Frey PA. Surprises and revelations in biochemistry: 1950-2000 Biochemistry and Molecular Biology Education. 30: 152-162. DOI: 10.1002/bmb.2002.494030030067  1
2001 Frey PA. The role of radicals in enzymatic processes. Chemical Record (New York, N.Y.). 1: 277-89. PMID 11893068 DOI: 10.1002/tcr.1013  1
2001 Frey PA. Enzymology. Coenzymes and radicals. Science (New York, N.Y.). 294: 2489-90. PMID 11752561 DOI: 10.1126/science.1067916  1
2001 Frey PA, Booker SJ. Radical mechanisms of S-adenosylmethionine-dependent enzymes. Advances in Protein Chemistry. 58: 1-45. PMID 11665486 DOI: 10.1016/S0065-3233(01)58001-8  1
2001 Gross JW, Hegeman AD, Gerratana B, Frey PA. Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase. Biochemistry. 40: 12497-504. PMID 11601973 DOI: 10.1021/Bi011138C  1
2001 Wei Y, Lin J, Frey PA. 13C NMR analysis of electrostatic interactions between NAD+ and active site residues of UDP-galactose 4-epimerase: implications for the activation induced by uridine nucleotides. Biochemistry. 40: 11279-87. PMID 11551228 DOI: 10.1021/Bi011085Z  1
2001 Gerratana B, Cleland WW, Frey PA. Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase. Biochemistry. 40: 9187-95. PMID 11478886 DOI: 10.1021/Bi0108249  1
2001 Magnusson OT, Reed GH, Frey PA. Characterization of an allylic analogue of the 5'-deoxyadenosyl radical: an intermediate in the reaction of lysine 2,3-aminomutase. Biochemistry. 40: 7773-82. PMID 11425303 DOI: 10.1021/Bi0104569  1
2001 Frey PA. Radical mechanisms of enzymatic catalysis. Annual Review of Biochemistry. 70: 121-48. PMID 11395404 DOI: 10.1146/annurev.biochem.70.1.121  1
2001 Berger E, Arabshahi A, Wei Y, Schilling JF, Frey PA. Acid-base catalysis by UDP-galactose 4-epimerase: correlations of kinetically measured acid dissociation constants with thermodynamic values for tyrosine 149. Biochemistry. 40: 6699-705. PMID 11380265 DOI: 10.1021/Bi0104571  1
2001 Hegeman AD, Gross JW, Frey PA. Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site. Biochemistry. 40: 6598-610. PMID 11380254 DOI: 10.1021/Bi010441A  1
2001 Miller J, Bandarian V, Reed GH, Frey PA. Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate. Archives of Biochemistry and Biophysics. 387: 281-8. PMID 11370852 DOI: 10.1006/Abbi.2001.2261  1
2001 Neidhart D, Wei Y, Cassidy C, Lin J, Cleland WW, Frey PA. Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin. Biochemistry. 40: 2439-47. PMID 11327865 DOI: 10.1021/Bi002535A  1
2001 Tang KH, Chang CH, Frey PA. Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase. Biochemistry. 40: 5190-9. PMID 11318641 DOI: 10.1021/Bi010157J  1
2001 Llanos L, Briones R, Yévenes A, González-Nilo FD, Frey PA, Cardemil E. Mutation Arg336 to Lys in Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase originates an enzyme with increased oxaloacetate decarboxylase activity. Febs Letters. 493: 1-5. PMID 11277994 DOI: 10.1016/S0014-5793(01)02158-5  1
2001 Gerratana B, Frey PA, Cleland WW. Characterization of the transition-state structure of the reaction of kanamycin nucleotidyltransferase by heavy-atom kinetic isotope effects. Biochemistry. 40: 2972-7. PMID 11258909 DOI: 10.1021/Bi002557X  1
2001 Chen D, Frey PA. Identification of lysine 346 as a functionally important residue for pyridoxal 5'-phosphate binding and catalysis in lysine 2, 3-aminomutase from Bacillus subtilis. Biochemistry. 40: 596-602. PMID 11148055 DOI: 10.1021/Bi002265W  1
2001 Frey PA. Strong hydrogen bonding in molecules and enzymatic complexes Magnetic Resonance in Chemistry. 39: S190-S198.  1
2000 Cosper NJ, Booker SJ, Ruzicka F, Frey PA, Scott RA. Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase. Biochemistry. 39: 15668-73. PMID 11123891 DOI: 10.1021/Bi0022184  1
2000 Gross JW, Hegeman AD, Vestling MM, Frey PA. Characterization of enzymatic processes by rapid mix-quench mass spectrometry: the case of dTDP-glucose 4,6-dehydratase. Biochemistry. 39: 13633-40. PMID 11076501 DOI: 10.1021/Bi001963D  1
2000 Frey PA, Reed GH. Radical mechanisms in adenosylmethionine- and adenosylcobalamin-dependent enzymatic reactions. Archives of Biochemistry and Biophysics. 382: 6-14. PMID 11051091 DOI: 10.1006/Abbi.2000.2010  1
2000 Wu W, Booker S, Lieder KW, Bandarian V, Reed GH, Frey PA. Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism. Biochemistry. 39: 9561-70. PMID 10924153 DOI: 10.1021/Bi000658P  1
2000 Cassidy CS, Lin J, Frey PA. The deuterium isotope effect on the NMR signal of the low-barrier hydrogen bond in a transition-state analog complex of chymotrypsin. Biochemical and Biophysical Research Communications. 273: 789-92. PMID 10873682 DOI: 10.1006/bbrc.2000.2986  1
2000 Chen D, Ruzicka FJ, Frey PA. A novel lysine 2,3-aminomutase encoded by the yodO gene of bacillus subtilis: characterization and the observation of organic radical intermediates. The Biochemical Journal. 348: 539-49. PMID 10839984 DOI: 10.1042/0264-6021:3480539  1
2000 Abend A, Bandarian V, Reed GH, Frey PA. Identification of cis-ethanesemidione as the organic radical derived from glycolaldehyde in the suicide inactivation of dioldehydrase and of ethanolamine ammonia-lyase. Biochemistry. 39: 6250-7. PMID 10821701 DOI: 10.1021/Bi992963K  1
2000 Geeganage S, Ling VW, Frey PA. Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: an essential serine and a nonessential cysteine. Biochemistry. 39: 5397-404. PMID 10820011 DOI: 10.1021/Bi992594S  1
2000 Ruzicka FJ, Lieder KW, Frey PA. Lysine 2,3-aminomutase from Clostridium subterminale SB4: mass spectral characterization of cyanogen bromide-treated peptides and cloning, sequencing, and expression of the gene kamA in Escherichia coli. Journal of Bacteriology. 182: 469-76. PMID 10629195 DOI: 10.1128/JB.182.2.469-476.2000  1
2000 Chang CH, Frey PA. Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-lysine 5, 6-aminomutase from Clostridium sticklandii. The Journal of Biological Chemistry. 275: 106-14. PMID 10617592 DOI: 10.1074/jbc.275.1.106  1
2000 Lin J, Frey PA. Strong hydrogen bonds in aqueous and aqueous-acetone solutions of dicarboxylic acids: Activation energies for exchange and deuterium fractionation factors [17] Journal of the American Chemical Society. 122: 11258-11259. DOI: 10.1021/Ja003060D  1
2000 Magnusson OT, Frey PA. Synthesis and characterization of 3',4'-anhydroadenosylcobalamin: A coenzyme B12 analogue with unusual properties Journal of the American Chemical Society. 122: 8807-8813. DOI: 10.1021/Ja0013780  1
2000 Liu Y, Arabshahi A, Frey PA. Rate enhancements brought about by uridine nucleotides in the reduction of NAD+ at the active site of UDP-galactose 4-epimerase Bioorganic Chemistry. 28: 29-37. DOI: 10.1006/bioo.1999.1158  1
2000 Magnusson OT, Frey PA. Synthesis and characterization of 3′,4′-anhydroadenosylcobalamin: A coenzyme B12 analogue with unusual properties Journal of the American Chemical Society. 122: X.  1
1999 Geeganage S, Frey PA. Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron. Biochemistry. 38: 13398-406. PMID 10529216 DOI: 10.1021/Bi9910631  1
1999 Frey PA, Frey TG. Synthesis of undecagold labeling compounds and their applications in electron microscopic analysis of multiprotein complexes. Journal of Structural Biology. 127: 94-100. PMID 10527897 DOI: 10.1006/jsbi.1999.4150  1
1999 Abend A, Garrison PN, Barnes LD, Frey PA. Stereochemical retention of the configuration in the action of Fhit on phosphorus-chiral substrates. Biochemistry. 38: 3668-76. PMID 10090754 DOI: 10.1021/Bi981895J  1
1999 Arabshahi A, Frey PA. Standard free energy for the hydrolysis of adenylylated T4 DNA ligase and the apparent pKa of lysine 159. The Journal of Biological Chemistry. 274: 8586-8. PMID 10085093 DOI: 10.1074/jbc.274.13.8586  1
1999 Cassidy CS, Reinhardt LA, Cleland WW, Frey PA. Hydrogen bonding in complexes of carboxylic acids with 1-alkylimidazoles: Steric and isotopic effects on low barrier hydrogen bonding Journal of the Chemical Society. Perkin Transactions 2. 635-641. DOI: 10.1039/A806387G  1
1999 Magnusson OT, Reed GH, Frey PA. Spectroscopic evidence for the participation of an allylic analogue of the 5'-deoxyadenosyl radical in the reaction of lysine 2,3-aminomutase [22] Journal of the American Chemical Society. 121: 9764-9765. DOI: 10.1021/Ja9925507  1
1998 Lin J, Westler WM, Cleland WW, Markley JL, Frey PA. Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin. Proceedings of the National Academy of Sciences of the United States of America. 95: 14664-8. PMID 9843946 DOI: 10.1073/Pnas.95.25.14664  1
1998 Beebe JA, Frey PA. Galactose mutarotase: purification, characterization, and investigations of two important histidine residues. Biochemistry. 37: 14989-97. PMID 9778377 DOI: 10.1021/Bi9816047  1
1998 Geeganage S, Frey PA. Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: insight into the molecular basis of galactosemia. Biochemistry. 37: 14500-7. PMID 9772178 DOI: 10.1021/Bi9815546  1
1998 Frey PA, Ballinger MD, Reed GH. S-adenosylmethionine: a 'poor man's coenzyme B12' in the reaction of lysine 2,3-aminomutase. Biochemical Society Transactions. 26: 304-10. PMID 9765869 DOI: 10.1042/Bst0260304  1
1998 Chen D, Frey PA. Phenylalanine hydroxylase from Chromobacterium violaceum. Uncoupled oxidation of tetrahydropterin and the role of iron in hyroxylation. The Journal of Biological Chemistry. 273: 25594-601. PMID 9748224 DOI: 10.1074/jbc.273.40.25594  1
1998 Cleland WW, Frey PA, Gerlt JA. The low barrier hydrogen bond in enzymatic catalysis. The Journal of Biological Chemistry. 273: 25529-32. PMID 9748211 DOI: 10.1074/Jbc.273.40.25529  1
1998 Lin J, Cassidy CS, Frey PA. Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin. Biochemistry. 37: 11940-8. PMID 9718318 DOI: 10.1021/Bi980278S  1
1998 Ruzicka FJ, Geeganage S, Frey PA. Kinetic mechanism of UDP-hexose synthase, a point variant of hexose-1-phosphate uridylyltransferase from Escherichia coli. Biochemistry. 37: 11385-92. PMID 9698386 DOI: 10.1021/Bi980877Z  1
1998 Krautwurst H, Bazaes S, González FD, Jabalquinto AM, Frey PA, Cardemil E. The strongly conserved lysine 256 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase is essential for phosphoryl transfer. Biochemistry. 37: 6295-302. PMID 9572844 DOI: 10.1021/Bi971515E  1
1998 Lieder KW, Booker S, Ruzicka FJ, Beinert H, Reed GH, Frey PA. S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance. Biochemistry. 37: 2578-85. PMID 9485408 DOI: 10.1021/Bi972417W  1
1998 Cloninger MJ, Frey PA. Steric enhancement of imidazole basicity in cis-urocanic acid derivatives: Models for the action of chymotrypsin Bioorganic Chemistry. 26: 323-333. DOI: 10.1006/bioo.1998.1115  1
1998 Cassidy CS, Lin J, Tobin JB, Frey PA. Low-barrier hydrogen bonding in aqueous and aprotic solutions of dicarboxylic acids: Spectroscopic characterization Bioorganic Chemistry. 26: 213-219. DOI: 10.1006/bioo.1998.1102  1
1998 Frey PA, Cleland WW. Are there strong hydrogen bonds in aqueous solutions? Bioorganic Chemistry. 26: 175-192. DOI: 10.1006/Bioo.1998.1097  1
1998 Beebe JA, Frey PA. Galactose mutarotase: Purification, characterization, and mechanistic studies Faseb Journal. 12: A1362.  1
1998 Chen D, Frey PA. Phenylalanine hydroxylase from Chromobacterium violaceum: Tetrahydropterin Oxidase Activity and the Role of Iron in Hydroxylation Faseb Journal. 12: A1363.  1
1998 Adrian D, Hegernan J, Frey PA. A comparative study of two sugar-nucleotide modifying enzymes: UDP-galactose-4-epimerase and dTDP-glucose4,6-dehydratase Faseb Journal. 12: A1363.  1
1997 Frey PA. Radicals in enzymatic reactions. Current Opinion in Chemical Biology. 1: 347-56. PMID 9667872  1
1997 Liu Y, Thoden JB, Kim J, Berger E, Gulick AM, Ruzicka FJ, Holden HM, Frey PA. Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 10675-84. PMID 9271498 DOI: 10.1021/Bi970430A  1
1997 Gerlt JA, Kreevoy MM, Cleland W, Frey PA. Understanding enzymic catalysis: the importance of short, strong hydrogen bonds. Chemistry & Biology. 4: 259-67. PMID 9195866 DOI: 10.1016/S1074-5521(97)90069-7  1
1997 Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 6294-304. PMID 9174344 DOI: 10.1021/Bi970025J  1
1997 Cassidy CS, Lin J, Frey PA. A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond. Biochemistry. 36: 4576-84. PMID 9109667 DOI: 10.1021/Bi962013O  1
1997 Thoden JB, Ruzicka FJ, Frey PA, Rayment I, Holden HM. Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site. Biochemistry. 36: 1212-22. PMID 9063869 DOI: 10.1021/Bi9626517  1
1997 Geeganage S, Frey PA. Characterization of Q168R mutant of galactose-1-phosphate uridylyltransferase from escherichia coli Faseb Journal. 11: A894.  1
1997 Cassidy CS, Lin J, Frey PA. The role of the low-barrier hydrogen bond in the mechanism of chymotrypsin Faseb Journal. 11: A894.  1
1996 Burke JR, Frey PA. Correlation of Electronic Effects in N-Alkylnicotinamides with NMR Chemical Shifts and Hydride Transfer Reactivity. The Journal of Organic Chemistry. 61: 530-533. PMID 11666971 DOI: 10.1021/Jo9511814  1
1996 Berk H, Buckel W, Thauer RK, Frey PA. Re-face stereospecificity at C4 of NAD(P) for alcohol dehydrogenase from Methanogenium organophilum and for (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans as determined by 1H-NMR spectroscopy. Febs Letters. 399: 92-4. PMID 8980127 DOI: 10.1016/S0014-5793(96)01292-6  1
1996 Thoden JB, Frey PA, Holden HM. High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol. Protein Science : a Publication of the Protein Society. 5: 2149-61. PMID 8931134 DOI: 10.1002/Pro.5560051102  1
1996 Lightcap ES, Frey PA. mu-Monothiopyrophosphate as a substrate for inorganic pyrophosphatase and UDP-glucose pyrophosphorylase. Archives of Biochemistry and Biophysics. 335: 183-90. PMID 8914849 DOI: 10.1006/abbi.1996.0496  1
1996 Wedekind JE, Frey PA, Rayment I. The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer. Biochemistry. 35: 11560-9. PMID 8794735 DOI: 10.1021/Bi9612677  1
1996 Chang CH, Ballinger MD, Reed GH, Frey PA. Lysine 2,3-aminomutase: rapid mix-freeze-quench electron paramagnetic resonance studies establishing the kinetic competence of a substrate-based radical intermediate. Biochemistry. 35: 11081-4. PMID 8780510 DOI: 10.1021/Bi960850K  1
1996 Liu Y, Vanhooke JL, Frey PA. UDP-galactose 4-epimerase: NAD+ content and a charge-transfer band associated with the substrate-induced conformational transition. Biochemistry. 35: 7615-20. PMID 8652544 DOI: 10.1021/Bi960102V  1
1996 Frey PA. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 461-70. PMID 8647345  1
1996 Arabshahi A, Ruzicka FJ, Geeganage S, Frey PA. Standard free energies for uridylyl group transfer by hexose-1-P uridylyltransferase and UDP-hexose synthase and for the hydrolysis of uridine 5'-phosphoimidazolate. Biochemistry. 35: 3426-8. PMID 8639492 DOI: 10.1021/bi952983w  1
1996 Krautwurst H, Berti M, Encinas MV, Frey PA. Reaction of wild-type C365S, and C458S saccharomyces cerevisiae phosphoenolpyruvate carboxykinases with fluorescent iodoacetamide derivatives. Archives of Biochemistry and Biophysics. 327: 123-30. PMID 8615682 DOI: 10.1006/Abbi.1996.0100  1
1996 Thoden JB, Frey PA, Holden HM. Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. Biochemistry. 35: 2557-66. PMID 8611559 DOI: 10.1021/Bi952715Y  1
1996 Thoden JB, Frey PA, Holden HM. Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism. Biochemistry. 35: 5137-44. PMID 8611497 DOI: 10.1021/Bi9601114  1
1996 Tobin JB, Frey PA. Electrostatic acceleration of enolization in cationic ketones Journal of the American Chemical Society. 118: 12253-12260. DOI: 10.1021/Ja950573P  1
1995 Tobin JB, Whitt SA, Cassidy CS, Frey PA. Low-barrier hydrogen bonding in molecular complexes analogous to histidine and aspartate in the catalytic triad of serine proteases. Biochemistry. 34: 6919-24. PMID 7766600 DOI: 10.1021/Bi00021A002  1
1995 Ruzicka FJ, Wedekind JE, Kim J, Rayment I, Frey PA. Galactose-1-phosphate uridylyltransferase from Escherichia coli, a zinc and iron metalloenzyme. Biochemistry. 34: 5610-7. PMID 7727423 DOI: 10.1021/Bi00016A036  1
1995 Frey PA. Low-barrier hydrogen bonds. Science (New York, N.Y.). 268: 189. PMID 7716506  1
1995 Wu W, Lieder KW, Reed GH, Frey PA. Observation of a second substrate radical intermediate in the reaction of lysine 2,3-aminomutase: a radical centered on the beta-carbon of the alternative substrate, 4-thia-L-lysine. Biochemistry. 34: 10532-7. PMID 7654708 DOI: 10.1021/Bi00033A027  0.36
1995 Ballinger MD, Frey PA, Reed GH, LoBrutto R. Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement. Biochemistry. 34: 10086-93. PMID 7632680 DOI: 10.1021/Bi00031A033  1
1995 Frey PA, Arabshahi A. Standard free energy change for the hydrolysis of the alpha, beta-phosphoanhydride bridge in ATP. Biochemistry. 34: 11307-10. PMID 7547856  1
1994 Wedekind JE, Frey PA, Rayment I. Crystallization and preliminary crystallographic analysis of galactose-1-phosphate uridylyltransferase from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 50: 329-31. PMID 15299446 DOI: 10.1107/S0907444993012958  1
1994 Vanhooke JL, Frey PA. Characterization and activation of naturally occurring abortive complexes of UDP-galactose 4-epimerase from Escherichia coli. The Journal of Biological Chemistry. 269: 31496-504. PMID 7989316  1
1994 Arabshahi A, Frey PA. A simplified procedure for synthesizing nucleoside 1-thiotriphosphates: dATP alpha S, dGTP alpha S, UTP alpha S, and dTTP alpha S. Biochemical and Biophysical Research Communications. 204: 150-5. PMID 7945353 DOI: 10.1006/bbrc.1994.2438  1
1994 Tamada Y, Swanson BA, Arabshahi A, Frey PA. Preparation and characterization of a bifunctional fusion enzyme composed of UDP-galactose 4-epimerase and galactose-1-P uridylyltransferase. Bioconjugate Chemistry. 5: 660-5. PMID 7873670 DOI: 10.1021/Bc00030A023  1
1994 Frey PA, Whitt SA, Tobin JB. A low-barrier hydrogen bond in the catalytic triad of serine proteases. Science (New York, N.Y.). 264: 1927-30. PMID 7661899  1
1994 Yang YS, Datta A, Hainfeld JF, Furuya FR, Wall JS, Frey PA. Mapping the lipoyl groups of the pyruvate dehydrogenase complex by use of gold cluster labels and scanning transmission electron microscopy. Biochemistry. 33: 9428-37. PMID 7520749  1
1994 Chapeau MC, Frey PA. Synthesis of UDP-4-deoxy-4-fluoroglucose and UDP-4-deoxy-4-fluorogalactose and their Interactions with enzymes of nucleotide sugar metabolism Journal of Organic Chemistry. 59: 6994-6998. DOI: 10.1021/Jo00102A024  1
1993 Frey PA. Lysine 2,3-aminomutase: Is adenosylmethionine a poor man's adenosylcobalamin? Faseb Journal. 7: 662-670. PMID 8500691  1
1993 Frey PA, Reed GH. Lysine 2,3-aminomutase and the mechanism of the interconversion of lysine and beta-lysine Advances in Enzymology and Related Areas of Molecular Biology. 66: 1-39. PMID 8430513 DOI: 10.1002/9780470123126.Ch1  1
1993 Buchbinder JL, Baraniak J, Frey PA, Reed GH. Stereochemistry of metal ion coordination to the terminal thiophosphoryl group of adenosine 5'-O-(3-thiotriphosphate) at the active site of pyruvate kinase. Biochemistry. 32: 14111-6. PMID 8260493 DOI: 10.1021/Bi00214A006  1
1993 Swanson BA, Frey PA. Identification of lysine 153 as a functionally important residue in UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 32: 13231-6. PMID 8241178 DOI: 10.1021/Bi00211A035  1
1993 Burke JR, Frey PA. The importance of binding energy in catalysis of hydride transfer by UDP-galactose 4-epimerase: a 13C and 15N NMR and kinetic study. Biochemistry. 32: 13220-30. PMID 8241177 DOI: 10.1021/Bi00211A034  1
1993 Ruzicka FJ, Frey PA. The pH dependence for the hydrolysis of uridine 5'-phosphoimidazolates Bioorganic Chemistry. 21: 238-248. DOI: 10.1006/bioo.1993.1020  1
1992 Bauer AJ, Rayment I, Frey PA, Holden HM. The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 A resolution. Proteins. 12: 372-81. PMID 1579570 DOI: 10.1002/Prot.340120409  1
1992 Valdivia E, Gabel C, Reardon JE, CaJacob CA, Yang H, Wehbi RS, Scott GL, Frey PA, Fahien LA. Functional and morphological studies of mitochondria exposed to undecagold clusters: Biologic surfaces labeling with gold clusters Scanning Microscopy. 6: 799-815. PMID 1439671  1
1992 Ballinger MD, Frey PA, Reed GH. Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase Biochemistry. 31: 10782-10789. PMID 1329955 DOI: 10.1021/Bi00159A020  1
1992 Petrovich RM, Ruzicka FJ, Reed GH, Frey PA. Characterization of iron-sulfur clusters in lysine 2,3-aminomutase by electron paramagnetic resonance spectroscopy Biochemistry. 31: 10774-10781. PMID 1329954 DOI: 10.1021/Bi00159A019  1
1992 Ballinger MD, Reed GH, Frey PA. An organic radical in the lysine 2,3-aminomutase reaction Biochemistry®. 31: 949-953. PMID 1310425 DOI: 10.1021/Bi00119A001  1
1992 Frey PA, Bauer AJ, Vanhooke JL, Konopka JM, Rayment I, Holden HM. Chemical spectroscopic and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli. Journal of Nutritional Science and Vitaminology. 461-4. PMID 1297789 DOI: 10.3177/Jnsv.38.Special_461  1
1992 Lightcap ES, Frey PA. Discrete monomeric metaphosphate anion as an intermediate in the hydrolysis of μ-monothiopyrophosphate Journal of the American Chemical Society. 114: 9750-9755. DOI: 10.1021/Ja00051A004  1
1992 Frey PA. 4 Nucleotidyltransferases and Phosphotransferases: Stereochemistry and Covalent Intermediates Enzymes. 20: 141-186. DOI: 10.1016/S1874-6047(08)60022-0  1
1991 Song KB, Frey PA. Molecular properties of lysine-2,3-aminomutase Journal of Biological Chemistry. 266: 7651-7655. PMID 2019591  1
1991 Bauer AJ, Rayment I, Frey PA, Holden HM. The isolation, purification, and preliminary crystallographic characterization of UDP-galactose-4-epimerase from Escherichia coli Proteins: Structure, Function and Genetics. 9: 135-142. PMID 2008433 DOI: 10.1002/Prot.340090207  1
1991 Petrovich RM, Ruzicka FJ, Reed GH, Frey PA. Metal cofactors of lysine-2,3-aminomutase Journal of Biological Chemistry. 266: 7656-7660. PMID 1850415  1
1991 Halkides CJ, Lightcap ES, Frey PA. The substrate reactivity of μ-monothiopyrophosphate with pyrophosphate-dependent phosphofructokinase: Evidence for a dissociative transition state in enzymatic phosphoryl group transfer Biochemistry. 30: 10313-10322. PMID 1657145 DOI: 10.1021/Bi00106A032  1
1991 Lightcap ES, Halkides CJ, Frey PA. Interactions of metal ions with μ-monothiopyrophosphate Biochemistry. 30: 10307-10313. PMID 1657144 DOI: 10.1021/Bi00106A031  1
1991 Lightcap ES, Frey PA. Evidence for monomeric metaphosphate as an intermediate in the hydrolysis of μ-monothiopyrophosphate Journal of the American Chemical Society. 113: 9415-9416. DOI: 10.1021/Ja00024A084  1
1991 Halkides CJ, Frey PA. The mechanism of the hydrolysis of μ-monothiopyrophosphate Journal of the American Chemical Society. 113: 9843-9848.  1
1990 Van Pelt JE, Mooberry ES, Frey PA. 1H, 13C, and 31P nuclear magnetic resonance spectral assignments for tobramycin, 2''-(adenosine-5'-phosphoryl)-tobramycin and 2''-(adenosine-5'-thiophosphoryl)-tobramycin. Archives of Biochemistry and Biophysics. 280: 284-91. PMID 2369120 DOI: 10.1016/0003-9861(90)90331-R  1
1990 Kim J, Ruzicka F, Frey PA. Remodeling hexose-1 -phosphate uridylyltransferase: Mechanism-inspired mutation into a new enzyme, UDP-hexose synthase Biochemistry. 29: 10590-10593. PMID 2271670 DOI: 10.1021/Bi00499A003  1
1990 Moss ML, Frey PA. Activation of lysine 2,3-aminomutase by S-adenosylmethionine Journal of Biological Chemistry. 265: 18112-18115. PMID 2211686  1
1990 Frey PA, Moss M, Petrovich R, Baraniak J. The roles of S-adenosylmethionine and pyridoxal phosphate in the lysine 2,3-aminomutase reaction Annals of the New York Academy of Sciences. 585: 368-378. PMID 2192619 DOI: 10.1111/j.1749-6632.1990.tb28069.x  1
1990 Flentke GR, Frey PA. Reaction of uridine diphosphate galactose 4-epimerase with a suicide inactivator Biochemistry. 29: 2430-2436. PMID 2186813 DOI: 10.1021/Bi00461A029  1
1990 Han O, Frey PA. Chemical model for the pyridoxal 5'-phosphate dependent lysine aminomutases Journal of the American Chemical Society. 112: 8982-8983. DOI: 10.1021/Ja00180A054  1
1990 Yang YS, Frey PA. Solvent effects on the solvolysis of ADPβS Bioorganic Chemistry. 18: 373-380. DOI: 10.1016/0045-2068(90)90021-V  1
1990 Frey PA. Importance of organic radicals in enzymatic cleavage of unactivated C-H bonds Chemical Reviews. 90: 1343-1357.  1
1989 Frey PA, Flournoy DS, Gruys K, Yang YS. Intermediates in reductive transacetylation catalyzed by pyruvate dehydrogenase complex Annals of the New York Academy of Sciences. 573: 21-35. PMID 2699398 DOI: 10.1111/j.1749-6632.1989.tb14984.x  1
1989 Frey PA. 2-Acetylthiamin pyrophosphate: An enzyme-bound intermediate in thiamin pyrophosphate-dependent reactions Biofactors. 2: 1-9. PMID 2679649  1
1989 Konopka JM, Halkides CJ, Vanhooke JL, Gorenstein DG, Frey PA. UDP-galactose 4-epimerase. Phosphorus-31 nuclear magnetic resonance analysis of NAD+ and NADH bound at the active site Biochemistry. 28: 2645-2654. PMID 2659075 DOI: 10.1021/Bi00432A043  1
1989 Gruys KJ, Datta A, Frey PA. 2-acetylthiamin pyrophosphate (acetyl-TPP) pH-rate profile for hydrolysis of acetyl-TPP and isolation of acetyl-TPP as a transient species in pyruvate dehydrogenase catalyzed reactions Biochemistry. 28: 9071-9080. PMID 2605241 DOI: 10.1021/Bi00449A018  1
1989 Field TL, Reznikoff WS, Frey PA. Galactose-1-phosphate uridylyltransferase: identification of histidine-164 and histidine-166 as critical residues by site-directed mutagenesis. Biochemistry. 28: 2094-9. PMID 2541773 DOI: 10.1021/Bi00431A019  1
1989 Flournoy DS, Frey PA. Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate Biochemistry. 28: 9594-9602. PMID 2514803 DOI: 10.1021/Bi00451A007  1
1989 Yang YS, Frey PA. 2-Ketoacid dehydrogenase complexes of Escherichia coli: Stereospecificities of the three components for (R)-lipoate Archives of Biochemistry and Biophysics. 268: 465-474. PMID 2492417 DOI: 10.1016/0003-9861(89)90314-7  1
1989 Baraniak J, Moss ML, Frey PA. Lysine 2,3-aminomutase. Support for a mechanism of hydrogen transfer involving S-adenosylmethionine Journal of Biological Chemistry. 264: 1357-1360. PMID 2492274  1
1988 Iyengar R, Frey PA. Epimerization in the synthesis of thiophosphoanhydrides Bioorganic Chemistry. 16: 52-61. DOI: 10.1016/0045-2068(88)90037-5  1
1987 Cornwell TL, Adhya SL, Reznikoff WS, Frey PA. The nucleotide sequence of the gal T gene of Escherichia coli. Nucleic Acids Research. 15: 8116. PMID 2823224 DOI: 10.1093/Nar/15.19.8116  1
1986 Konopka JM, Lardy HA, Frey PA. Stereochemical course of thiophosphoryl transfer catalyzed by cytosolic phosphoenolpyruvate carboxykinase. Biochemistry. 25: 5571-5. PMID 3778874 DOI: 10.1021/Bi00367A034  1
1986 Flournoy DS, Frey PA. Pyruvate dehydrogenase and 3-fluoropyruvate: chemical competence of 2-acetylthiamin pyrophosphate as an acetyl group donor to dihydrolipoamide. Biochemistry. 25: 6036-43. PMID 3098283 DOI: 10.1021/Bi00368A030  1
1985 Cajacob CA, Frey PA, Hainfeld JF, Wall JS, Yang H. Escherichia coli pyruvate dehydrogenase complex: Particle masses of the complex and componen enzymes measured by scanning transmission electron microscopy Biochemistry. 24: 2425-2431. PMID 3925985 DOI: 10.1021/Bi00331A006  1
1985 Meade TJ, Iyengar R, Frey PA. Synthesis and rearrangements of alkyl phosphorothioates Journal of Organic Chemistry. 50: 936-940. DOI: 10.1002/Chin.198535239  1
1984 Yang H, Reardon JE, Frey PA. Synthesis of undecagold cluster molecules as biochemical labeling reagents. 2. Bromoacetyl and maleimido undecagold clusters. Biochemistry. 23: 3857-62. PMID 6487582 DOI: 10.1021/Bi00312A010  1
1984 Reardon JE, Frey PA. Synthesis of undecagold cluster molecules as biochemical labeling reagents. 1. Monoacyl and mono[N-(succinimidooxy)succinyl] undecagold clusters. Biochemistry. 23: 3849-56. PMID 6487581 DOI: 10.1021/Bi00312A009  1
1984 Sheu KF, Ho HT, Nolan LD, Markovitz P, Richard JP, Utter MF, Frey PA. Stereochemical course of thiophosphoryl group transfer catalyzed by mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 23: 1779-83. PMID 6372862 DOI: 10.1021/Bi00303A030  1
1980 Richard JP, Carr MC, Ives DH, Frey PA. The stereochemical course of thiophosphoryl group transfer catalyzed by adenosine kinase. Biochemical and Biophysical Research Communications. 94: 1052-6. PMID 6249295 DOI: 10.1016/0006-291X(80)90525-2  1
1980 Pliura DH, Schomburg D, Richard JP, Frey PA, Knowles JR. Stereochemical course of a phosphokinase using a chiral [18O]phosphorothioate. Comparison with the transfer of a chiral [16O,17O,18O]phosphoryl group. Biochemistry. 19: 325-9. PMID 6243477 DOI: 10.1021/Bi00543A012  0.4
1978 Wong SS, Frey PA. Uridine diphosphate galactose 4-epimerase: Nucleotide and 8-anilino-1-naphthalenesulfonate binding properties of the substrate binding site Biochemistry. 17: 3551-3556. PMID 210796 DOI: 10.1021/Bi00610A020  1
1977 Wong SS, Frey PA. Fluorescence and nucleotide binding properties of Escherichia coli uridine diphosphate galactose 4-epimerase: Support for a model for nonstereospecific action Biochemistry. 16: 298-305. PMID 189796 DOI: 10.1021/Bi00621A022  1
1976 Wong SS, Frey PA. UDPgalactose 4-epimerase catalyzed oxygen dependent reduction of a free radical substrate analogue by two electron reducing agents [47] Journal of the American Chemical Society. 98: 7886-7887. PMID 791990 DOI: 10.1021/Ja00440A104  1
1971 Essenberg MK, Frey PA, Abeles RH. Studies on the mechanism of hydrogen transfer in the coenzyme B12 dependent dioldehydrase reaction II. Journal of the American Chemical Society. 93: 1242-51. PMID 5545927 DOI: 10.1021/Ja00734A036  1
1971 Frey PA, Kokesh FC, Westheimer FH. A reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol. Journal of the American Chemical Society. 93: 7266-9. PMID 5127415 DOI: 10.1021/Ja00755A024  1
1970 Frey PA, Essenberg MK, Abeles RH, Kerwar SS. Comments on a proposed mechanism of action of B12 coenzyme. Journal of the American Chemical Society. 92: 4488-9. PMID 5428391 DOI: 10.1021/Ja00717A074  1
1967 Frey PA, Kerwar SS, Abeles RH. The participation of the two non-equivalent C-5' hydrogens of B 12-coenzyme in the catalytic process. Biochemical and Biophysical Research Communications. 29: 873-9. PMID 6077819 DOI: 10.1016/0006-291X(67)90301-4  1
1967 Frey PA, Essenberg MK, Abeles RH. Studies on the mechanism of hydrogen transfer in the cobamide coenzyme-dependent dioldehydrase reaction. The Journal of Biological Chemistry. 242: 5369-77. PMID 6065100  1
1966 Wagner OW, Lee HA, Frey PA, Abeles RH. Studies on the mechanism of action of cobamide coenzymes. Chemical properties of the enzyme-coenzyme complex. The Journal of Biological Chemistry. 241: 1751-62. PMID 5945850  1
1966 Abeles RH, Frey PA. Role of B12 coenzymes in the dioldehydrase reaction. Federation Proceedings. 25: 1639-41. PMID 5927397  1
1966 Frey PA, Abeles RH. The role of the B12 coenzyme in the conversion of 1,2-propanediol to propionaldehyde. The Journal of Biological Chemistry. 241: 2732-3. PMID 5911645  1
1966 Zagalak B, Frey PA, Karabatsos GL, Abeles RH. The stereochemistry of the conversion of D and L 1,2-propanediols to propionaldehyde. The Journal of Biological Chemistry. 241: 3028-35. PMID 4287906  1
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