John Andrew MacKay, PhD - Publications

Affiliations: 
2008- Pharmaceutical Sciences University of Southern California, Los Angeles, CA, United States 
Area:
Pharmacy, Nanotechnology, Materials Science Engineering
Website:
www.mackaylab.com

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tyrpak DR, Li Y, Lei S, Avila H, MacKay JA. Single-Cell Quantification of the Transition Temperature of Intracellular Elastin-like Polypeptides. Acs Biomaterials Science & Engineering. PMID 33455201 DOI: 10.1021/acsbiomaterials.0c01117  0.794
2020 Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA. Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium. International Journal of Molecular Sciences. 21. PMID 32859014 DOI: 10.3390/Ijms21176157  0.782
2020 Tyrpak DR, Wang Y, Avila H, Guo H, Fu R, Truong AT, Park M, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Caveolin elastin-like polypeptide fusions mediate temperature-dependent assembly of caveolar microdomains. Acs Biomaterials Science & Engineering. 6: 198-204. PMID 32542186 DOI: 10.1021/Acsbiomaterials.9B01331  0.771
2020 Vaikari VP, Park M, Keossayan L, MacKay JA, Alachkar H. Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia. Nanomedicine : Nanotechnology, Biology, and Medicine. 102236. PMID 32535112 DOI: 10.1016/J.Nano.2020.102236  0.638
2020 Peddi S, MacKay JA. Berunda polypeptides carrying rapalogues inhibit tumor mTORC1 better than oral everolimus. Biomacromolecules. PMID 32484665 DOI: 10.1021/Acs.Biomac.0C00375  0.698
2020 Park M, Vaikari VP, Lam AT, Zhang Y, MacKay JA, Alachkar H. Anti-FLT3 nanoparticles for acute myeloid leukemia: Preclinical pharmacology and pharmacokinetics. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32428520 DOI: 10.1016/J.Jconrel.2020.05.021  0.709
2020 Hsueh PY, Ju Y, Vega A, Edman MC, MacKay JA, Hamm-Alvarez SF. A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye. International Journal of Molecular Sciences. 21. PMID 32326657 DOI: 10.3390/Ijms21082758  0.791
2020 Park M, Vaikari V, Dhandhukia J, Alachkar H, MacKay JA. A Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-like Polypeptides Assembles Biologically-Active Nanoparticles. Bioconjugate Chemistry. PMID 32319752 DOI: 10.1021/Acs.Bioconjchem.0C00204  0.822
2020 Truong AT, Hamada K, Yamada Y, Guo H, Kikkawa Y, Okamoto CT, MacKay JA, Nomizu M. Evaluation of extracellular matrix mimetic laminin bioactive peptide and elastin-like polypeptide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32248607 DOI: 10.1096/Fj.201902794R  0.807
2020 Peddi S, Roberts SK, MacKay JA. Nanotoxicology of an elastin-like polypeptide rapamycin formulation for breast cancer. Biomacromolecules. PMID 31927993 DOI: 10.1021/Acs.Biomac.9B01431  0.735
2020 Vaikari VP, Park M, Mackay JA, Alachkar H. Abstract 537: Preclinical development and activity of Anti-FLT3 nanoworms in acute myeloid leukemia Cancer Research. 80: 537-537. DOI: 10.1158/1538-7445.Am2020-537  0.665
2020 Truong AT, Hamada K, Yamada Y, Guo H, Kikkawa Y, Okamoto CT, MacKay JA, Nomizu M. The biological activity of extracellular matrix mimetic elastin‐like polypeptide‐laminin α1 peptide The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00262  0.768
2019 Li Z, Sreekumar PG, Peddi S, Hinton DR, Kannan R, MacKay JA. The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress. Nanomedicine : Nanotechnology, Biology, and Medicine. 102111. PMID 31655204 DOI: 10.1016/J.Nano.2019.102111  0.767
2019 Ju Y, Guo H, Yarber F, Edman MC, Peddi S, Janga SR, MacKay JA, Hamm-Alvarez SF. Molecular Targeting of Immunosuppressants Using a Bi-functional Elastin-Like Polypeptide. Bioconjugate Chemistry. PMID 31408605 DOI: 10.1021/Acs.Bioconjchem.9B00462  0.766
2019 Kouhi A, Yao Z, Zheng L, Li Z, Hu P, Epstein AL, MacKay JA. Generation of a monoclonal antibody to detect Elastin-Like Polypeptides. Biomacromolecules. PMID 31276401 DOI: 10.1021/Acs.Biomac.9B00503  0.366
2019 Klinngam W, Janga SR, Lee C, Ju Y, Yarber F, Shah M, Guo H, Wang D, MacKay JA, Edman MC, Hamm-Alvarez SF. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome. Scientific Reports. 9: 9559. PMID 31267034 DOI: 10.1038/S41598-019-45966-7  0.77
2019 Lee C, Guo H, Klinngam W, Janga SR, Yarber F, Peddi S, Edman MC, Tiwari N, Liu S, Louie SG, Hamm-Alvarez SF, MacKay JA. Berunda polypeptides: Bi-headed rapamycin carriers for subcutaneous treatment of autoimmune dry eye disease. Molecular Pharmaceutics. PMID 31095909 DOI: 10.1021/Acs.Molpharmaceut.9B00263  0.796
2019 Wang W, Lee C, Pastuszka M, Laurie GW, MacKay JA. Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses. Pharmaceutics. 11. PMID 31067782 DOI: 10.3390/Pharmaceutics11050221  0.779
2018 Peddi S, Pan X, MacKay JA. Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis. Frontiers in Pharmacology. 9: 1184. PMID 30386244 DOI: 10.3389/Fphar.2018.01184  0.73
2017 Dhandhukia JP, Li Z, Peddi S, Kakan S, Mehta A, Tyrpak D, Despanie J, MacKay JA. Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics. 7: 3856-3872. PMID 29109782 DOI: 10.7150/Thno.19981  0.797
2017 Dhandhukia JP, Shi P, Peddi S, Li Z, Aluri SR, Ju Y, Brill D, Wang W, Janib S, Lin YA, Liu S, Cui H, MacKay JA. Bi-functional elastin-like polypeptide nanoparticles bind rapamycin and integrins, and suppress tumor growth in vivo. Bioconjugate Chemistry. PMID 28937754 DOI: 10.1021/Acs.Bioconjchem.7B00469  0.802
2017 Dhandhukia J, Brill D, Kouhi A, Pastuszka M, MacKay JA. Elastin-Like Polypeptide Switches- a Design Strategy to Detect Multimeric Proteins. Protein Science : a Publication of the Protein Society. PMID 28639381 DOI: 10.1002/pro.3215  0.812
2017 Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Investigative Ophthalmology & Visual Science. 58: 372-385. PMID 28122086 DOI: 10.1167/Iovs.16-19159  0.657
2015 Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26578439 DOI: 10.1016/J.Jconrel.2015.11.010  0.81
2015 Pastuszka MK, MacKay JA. Engineering structure and function using thermoresponsive biopolymers. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. PMID 26112277 DOI: 10.1002/wnan.1350  0.768
2015 Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. Journal of Controlled Release : Official Journal of the Controlled Release Society. 208: 2-13. PMID 25523518 DOI: 10.1016/J.Jconrel.2014.12.017  0.809
2015 Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. A thermo-responsive protein treatment for dry eyes. Journal of Controlled Release : Official Journal of the Controlled Release Society. 199: 156-67. PMID 25481446 DOI: 10.1016/J.Jconrel.2014.11.016  0.8
2014 Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. Journal of Materials Chemistry. B, Materials For Biology and Medicine. 2: 8131-8141. PMID 25530855 DOI: 10.1039/C4Tb00979G  0.812
2014 Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Advanced Functional Materials. 24: 5340-5347. PMID 25419208 DOI: 10.1002/Adfm.201400715  0.811
2014 Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 191: 15-23. PMID 25016969 DOI: 10.1016/J.Jconrel.2014.07.003  0.785
2014 Janib SM, Gustafson JA, Minea RO, Swenson SD, Liu S, Pastuszka MK, Lock LL, Cui H, Markland FS, Conti PS, Li Z, MacKay JA. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 15: 2347-58. PMID 24871936 DOI: 10.1021/Bm401622Y  0.798
2014 Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 191: 4-14. PMID 24780268 DOI: 10.1016/J.Jconrel.2014.04.028  0.808
2014 Shi P, Gustafson JA, MacKay JA. Genetically engineered nanocarriers for drug delivery. International Journal of Nanomedicine. 9: 1617-26. PMID 24741309 DOI: 10.2147/Ijn.S53886  0.694
2014 Janib SM, Pastuszka M, Aluri S, Folchman-Wagner Z, Hsueh PY, Shi P, Yi-An, Cui H, Mackay JA. A quantitative recipe for engineering protein polymer nanoparticles. Polymer Chemistry. 5: 1614-1625. PMID 24511327 DOI: 10.1039/C3Py00537B  0.802
2014 Aluri SR, Shi P, Gustafson JA, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, MacKay JA. A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody. Acs Nano. 8: 2064-76. PMID 24484356 DOI: 10.1021/Nn403973G  0.793
2014 Shi P, Lin YA, Pastuszka M, Cui H, Mackay JA. Triggered sorting and co-assembly of genetically engineered protein microdomains in the cytoplasm. Advanced Materials (Deerfield Beach, Fla.). 26: 449-54. PMID 24136711 DOI: 10.1002/Adma.201303356  0.816
2014 Mohd Janib S, Minea RO, Swenson SD, Liu S, Pastuszka MK, Markland FS, Conti PS, Li Z, Mackay JA. The design of elastin-like polypeptides (ELPs) as a nanoparticulatebased therapeutic and diagnostic imaging agent Advanced Materials Research. 1024: 287-291. DOI: 10.4028/www.scientific.net/AMR.1024.287  0.716
2014 Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Synthetic Biology: Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains (Adv. Funct. Mater. 34/2014) Advanced Functional Materials. 24: 5309-5309. DOI: 10.1002/Adfm.201470224  0.783
2013 Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. Journal of Controlled Release : Official Journal of the Controlled Release Society. 171: 269-79. PMID 23892265 DOI: 10.1016/J.Jconrel.2013.07.016  0.819
2013 Shi P, Aluri S, Lin YA, Shah M, Edman M, Dhandhukia J, Cui H, MacKay JA. Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. Journal of Controlled Release : Official Journal of the Controlled Release Society. 171: 330-8. PMID 23714121 DOI: 10.1016/J.Jconrel.2013.05.013  0.817
2013 Dhandhukia J, Weitzhandler I, Wang W, MacKay JA. Switchable elastin-like polypeptides that respond to chemical inducers of dimerization. Biomacromolecules. 14: 976-85. PMID 23406497 DOI: 10.1021/Bm301558Q  0.815
2013 Janib SM, Liu S, Park R, Pastuszka MK, Shi P, Moses AS, Orosco MM, Lin YA, Cui H, Conti PS, Li Z, MacKay JA. Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 183-94. PMID 23093022 DOI: 10.1039/C2Ib20169K  0.821
2012 Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 13: 3439-44. PMID 23088632 DOI: 10.1021/Bm301090X  0.819
2012 Aluri S, Pastuszka MK, Moses AS, MacKay JA. Elastin-like peptide amphiphiles form nanofibers with tunable length. Biomacromolecules. 13: 2645-54. PMID 22849577 DOI: 10.1021/Bm300472Y  0.805
2012 Shah M, Hsueh PY, Sun G, Chang HY, Janib SM, MacKay JA. Biodegradation of elastin-like polypeptide nanoparticles. Protein Science : a Publication of the Protein Society. 21: 743-50. PMID 22434766 DOI: 10.1002/Pro.2063  0.832
2011 Chen M, McDaniel JR, Mackay JA, Chilkoti A. NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS. Technology and Innovation. 13: 5-25. PMID 24077873 DOI: 10.3727/194982411X13003853539948  0.708
2011 Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. Journal of Controlled Release : Official Journal of the Controlled Release Society. 155: 218-26. PMID 21699930 DOI: 10.1016/J.Jconrel.2011.06.010  0.834
2010 Mackay JA, Callahan DJ, Fitzgerald KN, Chilkoti A. Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides. Biomacromolecules. 11: 2873-9. PMID 20925333 DOI: 10.1021/Bm100571J  0.638
2010 McDaniel JR, Mackay JA, Quiroz FG, Chilkoti A. Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes. Biomacromolecules. 11: 944-52. PMID 20184309 DOI: 10.1021/Bm901387T  0.677
2010 Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR, Chilkoti A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 144: 2-9. PMID 20117157 DOI: 10.1016/J.Jconrel.2010.01.032  0.785
2009 MacKay JA, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection. Nature Materials. 8: 993-9. PMID 19898461 DOI: 10.1038/Nmat2569  0.819
2009 Gao W, Liu W, Mackay JA, Zalutsky MR, Toone EJ, Chilkoti A. In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics. Proceedings of the National Academy of Sciences of the United States of America. 106: 15231-6. PMID 19706892 DOI: 10.1073/Pnas.0904378106  0.748
2009 Aluri S, Janib SM, Mackay JA. Environmentally responsive peptides as anticancer drug carriers. Advanced Drug Delivery Reviews. 61: 940-52. PMID 19628014 DOI: 10.1016/J.Addr.2009.07.002  0.806
2009 Wu Y, MacKay JA, McDaniel JR, Chilkoti A, Clark RL. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules. 10: 19-24. PMID 19072041 DOI: 10.1021/Bm801033F  0.72
2008 MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 893-900. PMID 18388927 DOI: 10.1038/Mt.2008.36  0.482
2007 Lim DW, Trabbic-Carlson K, Mackay JA, Chilkoti A. Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. Biomacromolecules. 8: 1417-24. PMID 17407348 DOI: 10.1021/Bm060849T  0.47
2006 Chilkoti A, Christensen T, MacKay JA. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Current Opinion in Chemical Biology. 10: 652-7. PMID 17055770 DOI: 10.1016/J.Cbpa.2006.10.010  0.516
2006 Huang Z, Guo X, Li W, MacKay JA, Szoka FC. Acid-triggered transformation of diortho ester phosphocholine liposome. Journal of the American Chemical Society. 128: 60-1. PMID 16390121 DOI: 10.1021/Ja057024W  0.498
2005 Lee CC, MacKay JA, Fréchet JM, Szoka FC. Designing dendrimers for biological applications. Nature Biotechnology. 23: 1517-26. PMID 16333296 DOI: 10.1038/Nbt1171  0.536
2005 Huang Z, Li W, MacKay JA, Szoka FC. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 409-17. PMID 15727937 DOI: 10.1016/J.Ymthe.2004.10.013  0.508
2005 MacKay JA, Deen DF, Szoka FC. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Research. 1035: 139-53. PMID 15722054 DOI: 10.1016/J.Brainres.2004.12.007  0.505
2005 Li W, Huang Z, MacKay JA, Grube S, Szoka FC. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. The Journal of Gene Medicine. 7: 67-79. PMID 15515149 DOI: 10.1002/Jgm.634  0.513
2003 Mackay JA, Szoka FC. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. Journal of Dispersion Science and Technology. 24: 465-473. PMID 20808712 DOI: 10.1081/Dis-120021802  0.619
2003 Choi JS, MacKay JA, Szoka FC. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjugate Chemistry. 14: 420-9. PMID 12643753 DOI: 10.1021/Bc025625W  0.521
2003 Guo X, MacKay JA, Szoka FC. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophysical Journal. 84: 1784-95. PMID 12609880 DOI: 10.1016/S0006-3495(03)74986-8  0.471
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