Hilal A. Lashuel, Ph. D. - Publications

Molecular and Chemical Biology École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 

170 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Altay MF, Liu AKL, Holton JL, Parkkinen L, Lashuel HA. Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta Neuropathologica Communications. 10: 163. PMID 36371251 DOI: 10.1186/s40478-022-01468-8  0.318
2022 Lashuel HA, Mahul-Mellier AL, Novello S, Hegde RN, Jasiqi Y, Altay MF, Donzelli S, DeGuire SM, Burai R, Magalhães P, Chiki A, Ricci J, Boussouf M, Sadek A, Stoops E, et al. Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. Npj Parkinson's Disease. 8: 136. PMID 36266318 DOI: 10.1038/s41531-022-00388-7  0.729
2022 Teixidor J, Novello S, Ortiz D, Menin L, Lashuel HA, Bertsch A, Renaud P. On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid. Analytical Chemistry. PMID 35786947 DOI: 10.1021/acs.analchem.2c01577  0.688
2022 Nazarov S, Chiki A, Boudeffa D, Lashuel HA. Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. Journal of the American Chemical Society. 144: 10723-10735. PMID 35679155 DOI: 10.1021/jacs.2c00509  0.373
2021 Shillcock JC, Hastings J, Riguet N, Lashuel HA. Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations. Computational and Structural Biotechnology Journal. 20: 309-321. PMID 35070162 DOI: 10.1016/j.csbj.2021.12.017  0.329
2021 Limorenko G, Lashuel HA. Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society Reviews. PMID 34889934 DOI: 10.1039/d1cs00127b  0.349
2021 Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA. Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nature Communications. 12: 6579. PMID 34772920 DOI: 10.1038/s41467-021-26684-z  0.317
2021 Limorenko G, Lashuel HA. To target Tau pathologies, we must embrace and reconstruct their complexities. Neurobiology of Disease. 161: 105536. PMID 34718129 DOI: 10.1016/j.nbd.2021.105536  0.337
2021 Herrmann F, Hessmann M, Schaertl S, Berg-Rosseburg K, Brown CJ, Bursow G, Chiki A, Ebneth A, Gehrmann M, Hoeschen N, Hotze M, Jahn S, Johnson PD, Khetarpal V, Kiselyov A, ... ... Lashuel H, et al. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Scientific Reports. 11: 17977. PMID 34504195 DOI: 10.1038/s41598-021-97334-z  0.318
2021 Vieweg S, Mahul-Mellier AL, Ruggeri FS, Riguet N, DeGuire SM, Chiki A, Cendrowska U, Dietler G, Lashuel HA. The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1. Journal of Molecular Biology. 167222. PMID 34492254 DOI: 10.1016/j.jmb.2021.167222  0.309
2021 Chiki A, Zhang Z, Rajasekhar K, Abriata LA, Rostami I, Krapp LF, Boudeffa D, Dal Peraro M, Lashuel HA. Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation. Frontiers in Molecular Biosciences. 8: 686086. PMID 34381813 DOI: 10.3389/fmolb.2021.686086  0.348
2021 Lashuel HA. Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity? Current Opinion in Chemical Biology. 64: 67-75. PMID 34174698 DOI: 10.1016/j.cbpa.2021.05.006  0.305
2021 Kolla R, Gopinath P, Ricci J, Reif A, Rostami I, Lashuel HA. A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation. Journal of the American Chemical Society. 143: 9798-9812. PMID 34161085 DOI: 10.1021/jacs.1c03108  0.334
2021 Lashuel HA, Novello S. Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein. Neurobiology of Disease. 105417. PMID 34102275 DOI: 10.1016/j.nbd.2021.105417  0.766
2021 Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Lashuel HA, et al. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33545358 DOI: 10.1016/j.ymthe.2021.01.033  0.717
2021 Fares MB, Jagannath S, Lashuel HA. Reverse engineering Lewy bodies: how far have we come and how far can we go? Nature Reviews. Neuroscience. PMID 33432241 DOI: 10.1038/s41583-020-00416-6  0.31
2020 Chiki A, Ricci J, Hegde RN, Abriata LA, Reif A, Boudeffa D, Lashuel HA. Site-specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases. Chembiochem : a European Journal of Chemical Biology. PMID 32805086 DOI: 10.1002/Cbic.202000508  0.371
2020 Frey B, AlOkda A, Jackson MP, Riguet N, Duce JA, Lashuel HA. Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: what you see is not always what you get. Journal of Neurochemistry. PMID 32772367 DOI: 10.1111/Jnc.15147  0.377
2020 Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, ... Lashuel HA, et al. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models. The Embo Journal. e104671. PMID 32757223 DOI: 10.15252/Embj.2020104671  0.39
2020 Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, Gazit E, Hamley IW, Davis TP, Fändrich M, Otzen DE, Chapman MR, Dobson CM, Eisenberg DS, Mezzenga R. Half a century of amyloids: past, present and future. Chemical Society Reviews. PMID 32632432 DOI: 10.1039/C9Cs00199A  0.402
2020 Stephens AD, Zacharopoulou M, Moons R, Fusco G, Seetaloo N, Chiki A, Woodhams PJ, Mela I, Lashuel HA, Phillips JJ, De Simone A, Sobott F, Schierle GSK. Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity. Nature Communications. 11: 2820. PMID 32499486 DOI: 10.1038/S41467-020-16564-3  0.424
2020 Ait-Bouziad N, Chiki A, Limorenko G, Xiao S, Eliezer D, Lashuel HA. Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau. The Journal of Biological Chemistry. PMID 32341125 DOI: 10.1074/Jbc.Ra119.012517  0.392
2020 Lashuel HA. Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports. Neurobiology of Disease. 104876. PMID 32339655 DOI: 10.1016/J.Nbd.2020.104876  0.438
2020 Cendrowska U, Silva PJ, Ait-Bouziad N, Müller M, Guven ZP, Vieweg S, Chiki A, Radamaker L, Kumar ST, Fändrich M, Tavanti F, Menziani MC, Alexander-Katz A, Stellacci F, Lashuel HA. Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM. Proceedings of the National Academy of Sciences of the United States of America. PMID 32161130 DOI: 10.1073/Pnas.1916176117  0.425
2020 Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA. The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 32075919 DOI: 10.1073/Pnas.1913904117  0.427
2020 Kumar ST, Donzelli S, Chiki A, Syed MMK, Lashuel HA. A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research. Journal of Neurochemistry. PMID 31925956 DOI: 10.1111/Jnc.14955  0.467
2019 Haj-Yahya M, Gopinath P, Rajasekhar K, Mirbaha H, Diamond MI, Lashuel HA. Site-specific hyperphosphorylation inhibits, rather than promotes, tau fibrillization, seeding capacity and its microtubule binding. Angewandte Chemie (International Ed. in English). PMID 31863676 DOI: 10.1002/Anie.201913001  0.381
2019 Cariulo C, Verani M, Martufi P, Ingenito R, Finotto M, Deguire SM, Lavery DJ, Toledo-Sherman L, Lee R, Doherty EM, Vogt TF, Dominguez C, Lashuel HA, Petricca L, Caricasole A. Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochemical and Biophysical Research Communications. PMID 31677786 DOI: 10.1016/J.Bbrc.2019.09.097  0.391
2019 Yalinca H, Gehin CJC, Oleinikovas V, Lashuel HA, Gervasio FL, Pastore A. The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus. Frontiers in Molecular Biosciences. 6: 95. PMID 31632982 DOI: 10.3389/Fmolb.2019.00095  0.419
2019 Burtscher J, Copin JC, Rodrigues J, Kumar ST, Chiki A, Guillot de Suduiraut I, Sandi C, Lashuel HA. Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology. Neurobiology of Aging. 83: 11-20. PMID 31585362 DOI: 10.1016/J.Neurobiolaging.2019.08.007  0.339
2019 Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L. Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Frontiers in Neuroscience. 13: 889. PMID 31507364 DOI: 10.3389/Fnins.2019.00889  0.338
2019 Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR. α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 30651314 DOI: 10.1073/Pnas.1808845116  0.392
2018 Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFW. Single posttranslational modifications in the central repeat domains of Tau4 impact its aggregation and tubulin binding. Angewandte Chemie (International Ed. in English). PMID 30549369 DOI: 10.1002/Anie.201805238  0.427
2018 Deguire SM, Ruggeri FS, Fares MB, Chiki A, Cendrowska U, Dietler G, Lashuel HA. N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting. The Journal of Biological Chemistry. PMID 30185623 DOI: 10.1074/Jbc.Ra118.004621  0.391
2018 Mollenhauer B, DuBois BF, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty IM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, ... ... Lashuel HA, et al. Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study. Journal of Neurochemistry. PMID 30125936 DOI: 10.1111/Jnc.14569  0.325
2018 Reif A, Chiki A, Ricci J, Lashuel HA. Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy. Journal of Visualized Experiments : Jove. PMID 30010666 DOI: 10.3791/57506  0.4
2018 Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G. Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils. Proceedings of the National Academy of Sciences of the United States of America. PMID 29941606 DOI: 10.1073/Pnas.1721220115  0.442
2018 Etezadi D, Warner JB, Lashuel HA, Altug H. Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas. Acs Sensors. PMID 29845861 DOI: 10.1021/Acssensors.8B00115  0.386
2018 Haj-Yahya M, Lashuel HA. Protein semisynthesis provides access to Tau disease-associated post-translational modifications (PTMs) and paves the way to deciphering the Tau PTM code in health and diseased states. Journal of the American Chemical Society. PMID 29684271 DOI: 10.1021/Jacs.8B02668  0.449
2018 El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM. Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein Science : a Publication of the Protein Society. PMID 29603451 DOI: 10.1002/Pro.3412  0.386
2017 Etezadi D, Warner Iv JB, Ruggeri FS, Dietler G, Lashuel HA, Altug H. Nanoplasmonic mid-infrared biosensor for protein secondary structure detection. Light, Science & Applications. 6: e17029. PMID 30167280 DOI: 10.1038/Lsa.2017.29  0.386
2017 Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature Communications. 8: 1678. PMID 29162800 DOI: 10.1038/S41467-017-01575-4  0.426
2017 Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, et al. Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29162692 DOI: 10.1073/Pnas.1705372114  0.413
2017 Warner JB, Ruff K, Tan PS, Lemke EA, Pappu RV, Lashuel HA. Monomeric huntingtin exon 1 has similar overall structural features for wild type and pathological polyglutamine lengths. Journal of the American Chemical Society. PMID 28937758 DOI: 10.1021/Jacs.7B06659  0.381
2017 Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G. Amyloid single-cell cytotoxicity assays by nanomotion detection. Cell Death Discovery. 3: 17053. PMID 28845298 DOI: 10.1038/Cddiscovery.2017.53  0.411
2017 Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, et al. A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28734051 DOI: 10.1002/Mds.27090  0.352
2017 Daldin M, Fodale V, Cariulo C, Azzollini L, Verani M, Martufi P, Spiezia MC, Deguire SM, Cherubini M, Macdonald D, Weiss A, Bresciani A, Vonsattel JG, Petricca L, Marsh JL, ... ... Lashuel HA, et al. Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models. Scientific Reports. 7: 5070. PMID 28698602 DOI: 10.1038/S41598-017-05336-7  0.4
2017 Vicente Miranda H, Szego ÉM, Oliveira LM, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, ... ... Lashuel HA, et al. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain : a Journal of Neurology. PMID 28398476 DOI: 10.1093/Brain/Awx056  0.404
2017 Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA. Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6. Angewandte Chemie (International Ed. in English). PMID 28334491 DOI: 10.1002/Anie.201611750  0.354
2017 de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, ... ... Lashuel HA, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Plos Biology. 15: e2000374. PMID 28257421 DOI: 10.1371/Journal.Pbio.2000374  0.415
2016 Awad L, Jejelava N, Burai R, Lashuel HA. A novel caged-glutamine derivative as a tool to control the assembly of glutamine-containing amyloidogenic peptides. Chembiochem : a European Journal of Chemical Biology. PMID 27788286 DOI: 10.1002/Cbic.201600474  0.301
2016 Ruggeri FS, Vieweg S, Cendrowska U, Longo G, Chiki A, Lashuel HA, Dietler G. Nanoscale studies link amyloid maturity with polyglutamine diseases onset. Scientific Reports. 6: 31155. PMID 27499269 DOI: 10.1038/Srep31155  0.471
2016 Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Semisynthetic and in vitro phosphorylation of alpha-synuclein at Y39 promotes functional partly-helical membrane-bound states resembling those induced by PD mutations. Acs Chemical Biology. PMID 27356045 DOI: 10.1021/Acschembio.6B00539  0.362
2016 Vieweg S, Ansaloni A, Wang ZM, Warner JB, Lashuel HA. An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins enables New Insights into the PolyQ Dependence of Httex1 Aggregation and Fibril Formation. The Journal of Biological Chemistry. PMID 27002149 DOI: 10.1074/Jbc.M116.713982  0.433
2016 Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman VL, Masliah E, Lashuel HA. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839406 DOI: 10.1073/Pnas.1512876113  0.407
2016 Fauvet B, Lashuel HA. Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein. Methods in Molecular Biology (Clifton, N.J.). 1345: 3-20. PMID 26453202 DOI: 10.1007/978-1-4939-2978-8_1  0.419
2015 Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, Reynolds NP, Lashuel HA, Mezzenga R. Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angewandte Chemie (International Ed. in English). PMID 26636567 DOI: 10.1002/Anie.201508968  0.44
2015 Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA. Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. Plos One. 10: e0140880. PMID 26484876 DOI: 10.1371/Journal.Pone.0140880  0.325
2015 Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA. Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death. Cell Death and Differentiation. PMID 26138444 DOI: 10.1038/Cdd.2015.79  0.39
2015 Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A. Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on Threonine 3 and regulation by IKKβ. Biochemical and Biophysical Research Communications. PMID 26106822 DOI: 10.1016/J.Bbrc.2015.06.116  0.381
2015 Droste P, Frenzel A, Steinwand M, Pelat T, Thullier P, Hust M, Lashuel H, Dübel S. Structural differences of amyloid-β fibrils revealed by antibodies from phage display. Bmc Biotechnology. 15: 57. PMID 26084577 DOI: 10.1186/s12896-015-0146-8  0.341
2015 Burai R, Ait-Bouziad N, Chiki A, Lashuel HA. Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. Journal of the American Chemical Society. 137: 5041-52. PMID 25768729 DOI: 10.1021/Ja5131726  0.423
2015 Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of Biological Chemistry. 290: 9412-27. PMID 25657004 DOI: 10.1074/Jbc.M114.610774  0.331
2015 Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G. Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization. Angewandte Chemie (International Ed. in English). 54: 2462-6. PMID 25588987 DOI: 10.1002/Anie.201409050  0.452
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 85: 76-87. PMID 25533483 DOI: 10.1016/J.Neuron.2014.11.027  0.324
2015 Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA. Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiology of Disease. 74: 144-57. PMID 25173807 DOI: 10.1016/J.Nbd.2014.08.017  0.424
2015 Droste P, Frenzel A, Steinwand M, Pelat T, Thullier P, Hust M, Lashuel H, Dübel S. Structural differences of amyloid-β fibrils revealed by antibodies from phage display Bmc Biotechnology. 15. DOI: 10.1186/S12896-015-0146-8  0.434
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Erratum to Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein [(Neuron 85, (2015) 76-87] Neuron. 85. DOI: 10.1016/J.Neuron.2015.01.022  0.311
2014 Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity. The Journal of Biological Chemistry. 289: 21856-76. PMID 24936070 DOI: 10.1074/Jbc.M114.553297  0.365
2014 Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human Molecular Genetics. 23: 4491-509. PMID 24728187 DOI: 10.1093/Hmg/Ddu165  0.386
2014 Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA. One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease. Angewandte Chemie (International Ed. in English). 53: 1928-33. PMID 24446188 DOI: 10.1002/Anie.201307510  0.423
2014 Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Human Molecular Genetics. 23: 2858-79. PMID 24412932 DOI: 10.1093/Hmg/Ddt674  0.357
2014 Lashuel HA, Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wu F, Fraering PC, Masliah E. Novel Mechanism-Based Inhibitors of Aβ Aggregation and Toxicity Neurobiology of Aging. 35: 720-721. DOI: 10.1016/J.Neurobiolaging.2013.10.057  0.379
2013 Fournier M, Roux A, Garrigue J, Muriel MP, Blanche P, Lashuel HA, Anderson JP, Barbour R, Huang J, du Montcel ST, Brice A, Corti O. Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice. Bmc Neuroscience. 14: 135. PMID 24192137 DOI: 10.1186/1471-2202-14-135  0.385
2013 Santi S, Musi V, Descrovi E, Paeder V, Di Francesco J, Hvozdara L, van der Wal P, Lashuel HA, Pastore A, Neier R, Herzig HP. Real-time amyloid aggregation monitoring with a photonic crystal-based approach. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 14: 3476-82. PMID 24105966 DOI: 10.1002/Cphc.201300633  0.427
2013 Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A. Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 110: 17726-31. PMID 24043770 DOI: 10.1073/Pnas.1315654110  0.373
2013 Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA. One-pot total chemical synthesis of human α-synuclein. Chemical Communications (Cambridge, England). 49: 9254-6. PMID 23995579 DOI: 10.1039/C3Cc45353G  0.371
2013 Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: E3945-54. PMID 23983262 DOI: 10.1073/Pnas.1309991110  0.359
2013 Schmid AW, Fauvet B, Moniatte M, Lashuel HA. Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies. Molecular & Cellular Proteomics : McP. 12: 3543-58. PMID 23966418 DOI: 10.1074/Mcp.R113.032730  0.4
2013 Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M. Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of Neurochemistry. 125: 491-511. PMID 23452040 DOI: 10.1111/Jnc.12226  0.386
2013 Jeong JS, Ansaloni A, Mezzenga R, Lashuel HA, Dietler G. Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation. Journal of Molecular Biology. 425: 1765-81. PMID 23415897 DOI: 10.1016/J.Jmb.2013.02.005  0.475
2013 Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nature Reviews. Neuroscience. 14: 38-48. PMID 23254192 DOI: 10.1038/Nrn3406  0.427
2013 Wang ZM, Lashuel HA. Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity. Angewandte Chemie (International Ed. in English). 52: 562-7. PMID 23148019 DOI: 10.1002/Anie.201206561  0.384
2013 Santi S, Musi V, Descrovi E, Paeder V, Di Francesco J, Hvozdara L, van der Wal P, Lashuel HA, Pastore A, Neier R, Herzig HP. Cover Picture: Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach (ChemPhysChem 15/2013) Chemphyschem. 14: 3421-3421. DOI: 10.1002/Cphc.201390071  0.328
2012 El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H. Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket Plos One. 7. PMID 23028743 DOI: 10.1371/Journal.Pone.0045024  0.358
2012 Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, ... ... Lashuel HA, et al. Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. The Journal of Biological Chemistry. 287: 34786-800. PMID 22891248 DOI: 10.1074/Jbc.M112.357665  0.42
2012 Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH. Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction. Biochemical and Biophysical Research Communications. 424: 597-603. PMID 22776201 DOI: 10.1016/J.Bbrc.2012.06.159  0.361
2012 Fauvet B, Fares MB, Samuel F, Dikiy I, Tandon A, Eliezer D, Lashuel HA. Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein. The Journal of Biological Chemistry. 287: 28243-62. PMID 22718772 DOI: 10.1074/Jbc.M112.383711  0.383
2012 Adamcik J, Lara C, Usov I, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA, Hamley IW, Mezzenga R. Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale. 4: 4426-9. PMID 22688679 DOI: 10.1039/C2Nr30768E  0.398
2012 Yang B, Sun X, Lashuel H, Zhang Y. Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons Neuroscience Bulletin. 28: 233-239. PMID 22622822 DOI: 10.1007/S12264-012-1239-1  0.379
2012 Jan A, Lashuel HA. Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches. Methods in Molecular Biology (Clifton, N.J.). 849: 227-43. PMID 22528094 DOI: 10.1007/978-1-61779-551-0_16  0.435
2012 Butterfield S, Hejjaoui M, Fauvet B, Awad L, Lashuel HA. Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity. Journal of Molecular Biology. 421: 204-36. PMID 22342932 DOI: 10.1016/J.Jmb.2012.01.051  0.461
2012 Hejjaoui M, Butterfield S, Fauvet B, Vercruysse F, Cui J, Dikiy I, Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA. Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. Journal of the American Chemical Society. 134: 5196-210. PMID 22339654 DOI: 10.1021/Ja210866J  0.404
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, ... ... Lashuel HA, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/Jbc.M111.318949  0.35
2012 Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA. Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1536-44. PMID 22302797 DOI: 10.1523/Jneurosci.3784-11.2012  0.426
2011 Lu Y, Prudent M, Fauvet B, Lashuel HA, Girault HH. Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. Acs Chemical Neuroscience. 2: 667-75. PMID 22860160 DOI: 10.1021/Cn200074D  0.318
2011 Siman P, Blatt O, Moyal T, Danieli T, Lebendiker M, Lashuel HA, Friedler A, Brik A. Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European Journal of Chemical Biology. 12: 1097-104. PMID 21488138 DOI: 10.1002/Cbic.201100033  0.313
2011 Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PJ, Pfeifer A, Muhs A, Lashuel HA. Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. The Journal of Biological Chemistry. 286: 8585-96. PMID 21156804 DOI: 10.1074/Jbc.M110.172411  0.454
2011 Hejjaoui M, Haj-Yahya M, Kumar KS, Brik A, Lashuel HA. Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. Angewandte Chemie (International Ed. in English). 50: 405-9. PMID 21154793 DOI: 10.1002/Anie.201005546  0.404
2011 Braga CA, Follmer C, Palhano FL, Khattar E, Freitas MS, Romão L, Di Giovanni S, Lashuel HA, Silva JL, Foguel D. The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species. Journal of Molecular Biology. 405: 254-73. PMID 21050861 DOI: 10.1016/J.Jmb.2010.10.027  0.721
2010 Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck G, Lashuel HA, Moussa CE. Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Molecular Neurodegeneration. 5: 47. PMID 21050448 DOI: 10.1186/1750-1326-5-47  0.374
2010 Hinault MP, Cuendet AF, Mattoo RU, Mensi M, Dietler G, Lashuel HA, Goloubinoff P. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of Biological Chemistry. 285: 38173-82. PMID 20847048 DOI: 10.1074/Jbc.M110.127753  0.428
2010 Oueslati A, Fournier M, Lashuel HA. Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. Progress in Brain Research. 183: 115-45. PMID 20696318 DOI: 10.1016/S0079-6123(10)83007-9  0.424
2010 El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA. An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorganic & Medicinal Chemistry. 18: 5425-40. PMID 20639113 DOI: 10.1016/J.Bmc.2010.05.010  0.302
2010 Butterfield SM, Lashuel HA. Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. Angewandte Chemie (International Ed. in English). 49: 5628-54. PMID 20623810 DOI: 10.1002/Anie.200906670  0.361
2010 Jan A, Hartley DM, Lashuel HA. Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nature Protocols. 5: 1186-209. PMID 20539293 DOI: 10.1038/Nprot.2010.72  0.453
2010 Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA. Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. The Journal of Biological Chemistry. 285: 26581-98. PMID 20516071 DOI: 10.1074/Jbc.M110.113951  0.311
2010 Allaman I, Gavillet M, Bélanger M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ. Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3326-38. PMID 20203192 DOI: 10.1523/Jneurosci.5098-09.2010  0.358
2010 Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, ... ... Lashuel HA, et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3184-98. PMID 20203178 DOI: 10.1523/Jneurosci.5922-09.2010  0.378
2010 Di Giovanni S, Eleuteri S, Paleologou KE, Yin G, Zweckstetter M, Carrupt PA, Lashuel HA. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. The Journal of Biological Chemistry. 285: 14941-54. PMID 20150427 DOI: 10.1074/Jbc.M109.080390  0.446
2010 Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Phosphorylation of synucleins by members of the Polo-like kinase family. The Journal of Biological Chemistry. 285: 2807-22. PMID 19889641 DOI: 10.1074/Jbc.M109.081950  0.352
2010 Grimminger-Marquardt V, Lashuel HA. Structure and function of the molecular chaperone Hsp104 from yeast. Biopolymers. 93: 252-76. PMID 19768774 DOI: 10.1002/Bip.21301  0.437
2010 Butterfield S, Lashuel H. Wechselwirkungen zwischen amyloidogenen Proteinen und Membranen: Modellsysteme liefern mechanistische Einblicke Angewandte Chemie. 122: 5760-5788. DOI: 10.1002/Ange.200906670  0.328
2009 Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S, Fernandez CO, Lashuel HA, Benz R, Lange A, Zweckstetter M. Structural properties of pore-forming oligomers of alpha-synuclein. Journal of the American Chemical Society. 131: 17482-9. PMID 19888725 DOI: 10.1021/Ja9077599  0.443
2009 Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A. Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 48: 8090-4. PMID 19780082 DOI: 10.1002/Anie.200902936  0.322
2009 Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Roger T, Le Roy D, Karpinar DP, Leng L, Bucala R, Zweckstetter M, Calandra T, Lashuel HA. A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry. 48: 9858-70. PMID 19737008 DOI: 10.1021/Bi900957E  0.328
2009 Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, ... Lashuel HA, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. Plos One. 4: e6629. PMID 19680561 DOI: 10.1371/Journal.Pone.0006629  0.355
2009 Lashuel HA, Pappu RV. Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies. Chembiochem : a European Journal of Chemical Biology. 10: 1951-4. PMID 19598186 DOI: 10.1002/Cbic.200900373  0.325
2009 Camus MS, Mimna R, Schmid A, Chandravarkar A, Tuchscherer G, Lashuel HA, Mutter M. Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Advances in Experimental Medicine and Biology. 611: 281-2. PMID 19400193 DOI: 10.1007/978-0-387-73657-0_126  0.303
2009 Rospigliosi CC, McClendon S, Schmid AW, Ramlall TF, Barré P, Lashuel HA, Eliezer D. E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. Journal of Molecular Biology. 388: 1022-32. PMID 19345692 DOI: 10.1016/J.Jmb.2009.03.065  0.382
2009 Schmid AW, Chiappe D, Pignat V, Grimminger V, Hang I, Moniatte M, Lashuel HA. Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 284: 13128-42. PMID 19164286 DOI: 10.1074/Jbc.M809067200  0.359
2009 Lashuel HA. F3-02-05: The Role of post-translational modification (phosphorylation) in modulating alpha-synuclein, structure, aggregation and toxicity Alzheimer's & Dementia. 5: P124-P125. DOI: 10.1016/J.Jalz.2009.05.419  0.356
2008 Herrera FE, Chesi A, Paleologou KE, Schmid A, Munoz A, Vendruscolo M, Gustincich S, Lashuel HA, Carloni P. Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. Plos One. 3: e3394. PMID 18852892 DOI: 10.1371/Journal.Pone.0003394  0.385
2008 Arimon M, Grimminger V, Sanz F, Lashuel HA. Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils. Journal of Molecular Biology. 384: 1157-73. PMID 18851977 DOI: 10.1016/J.Jmb.2008.09.063  0.444
2008 El-Turk F, Cascella M, Ouertatani-Sakouhi H, Narayanan RL, Leng L, Bucala R, Zweckstetter M, Rothlisberger U, Lashuel HA. The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. Biochemistry. 47: 10740-56. PMID 18795803 DOI: 10.1021/Bi800603X  0.336
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/Jci35781  0.397
2008 Jan A, Gokce O, Luthi-Carter R, Lashuel HA. The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. The Journal of Biological Chemistry. 283: 28176-89. PMID 18694930 DOI: 10.1074/Jbc.M803159200  0.384
2008 Camus MS, Dos Santos S, Chandravarkar A, Mandal B, Schmid AW, Tuchscherer G, Mutter M, Lashuel HA. Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents. Chembiochem : a European Journal of Chemical Biology. 9: 2104-12. PMID 18683159 DOI: 10.1002/Cbic.200800245  0.387
2008 Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA. Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. The Journal of Biological Chemistry. 283: 16895-905. PMID 18343814 DOI: 10.1074/Jbc.M800747200  0.374
2007 Chafekar SM, Malda H, Merkx M, Meijer EW, Viertl D, Lashuel HA, Baas F, Scheper W. Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation. Chembiochem : a European Journal of Chemical Biology. 8: 1857-64. PMID 17763487 DOI: 10.1002/Cbic.200700338  0.418
2007 Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT. The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry. 46: 7107-18. PMID 17530780 DOI: 10.1021/Bi7000246  0.411
2007 Mimna R, Camus MS, Schmid A, Tuchscherer G, Lashuel HA, Mutter M. Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept. Angewandte Chemie (International Ed. in English). 46: 2681-4. PMID 17330907 DOI: 10.1002/Anie.200603681  0.378
2007 Follmer C, Romão L, Einsiedler CM, Porto TC, Lara FA, Moncores M, Weissmüller G, Lashuel HA, Lansbury P, Neto VM, Silva JL, Foguel D. Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein. Biochemistry. 46: 472-82. PMID 17209557 DOI: 10.1021/Bi061871+  0.372
2007 Tuchscherer G, Chandravarkar A, Camus MS, Bérard J, Murat K, Schmid A, Mimna R, Lashuel HA, Mutter M. Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Biopolymers. 88: 239-52. PMID 17206626 DOI: 10.1002/Bip.20663  0.362
2006 Lashuel HA, Hirling H. Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease. Acs Chemical Biology. 1: 420-4. PMID 17168518 DOI: 10.1021/Cb600331E  0.386
2006 Lansbury PT, Lashuel HA. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature. 443: 774-9. PMID 17051203 DOI: 10.1038/Nature05290  0.434
2006 Lashuel HA, Lansbury PT. Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Quarterly Reviews of Biophysics. 39: 167-201. PMID 16978447 DOI: 10.1017/S0033583506004422  0.451
2006 Saucède L, Dos Santos S, Chandravarkar A, Mandal B, Mimna R, Murat K, Camus MS, Bérard J, Grouzmann E, Adrian M, Dubochet J, Lopez J, Lashuel H, Tuchscherer G, Mutter M. Switch-peptides: From conformational studies to Alzheimer's disease Chimia. 60: 199-202. DOI: 10.2533/000942906777674921  0.416
2005 Lashuel HA, Aljabari B, Sigurdsson EM, Metz CN, Leng L, Callaway DJ, Bucala R. Amyloid fibril formation by macrophage migration inhibitory factor. Biochemical and Biophysical Research Communications. 338: 973-80. PMID 16286092 DOI: 10.1016/J.Bbrc.2005.10.040  0.491
2005 Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH. Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2083-4. PMID 16230335 DOI: 10.1096/Fj.05-4375Fje  0.398
2005 Wang L, Lashuel HA, Colón W. From hexamer to amyloid: marginal stability of apolipoprotein SAA2.2 leads to in vitro fibril formation at physiological temperature. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 139-48. PMID 16194868 DOI: 10.1080/13506120500223084  0.716
2005 Lashuel HA. Membrane permeabilization: a common mechanism in protein-misfolding diseases. Science of Aging Knowledge Environment : Sage Ke. 2005: pe28. PMID 16186179 DOI: 10.1126/Sageke.2005.38.Pe28  0.46
2005 Lashuel HA, Wall JS. Molecular electron microscopy approaches to elucidating the mechanisms of protein fibrillogenesis. Methods in Molecular Biology (Clifton, N.J.). 299: 81-101. PMID 15980597 DOI: 10.1385/1-59259-874-9:081  0.416
2005 Lashuel HA, Grillo-Bosch D. In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein. Methods in Molecular Biology (Clifton, N.J.). 299: 19-33. PMID 15980593 DOI: 10.1385/1-59259-874-9:019  0.468
2005 Morikawa M, Fryer JD, Sullivan PM, Christopher EA, Wahrle SE, DeMattos RB, O'Dell MA, Fagan AM, Lashuel HA, Walz T, Asai K, Holtzman DM. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiology of Disease. 19: 66-76. PMID 15837562 DOI: 10.1016/J.Nbd.2004.11.005  0.314
2005 Cox DL, Lashuel H, Lee KYC, Singh RRR. The materials science of protein aggregation Mrs Bulletin. 30: 452-457. DOI: 10.1557/Mrs2005.123  0.454
2004 Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of Molecular Neuroscience : Mn. 23: 23-34. PMID 15126689 DOI: 10.1385/Jmn:23:1-2:023  0.386
2003 Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society. 125: 15359-65. PMID 14664580 DOI: 10.1021/Ja0349296  0.412
2003 Kheterpal I, Lashuel HA, Hartley DM, Walz T, Lansbury PT, Wetzel R. Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. Biochemistry. 42: 14092-8. PMID 14640676 DOI: 10.1021/Bi0357816  0.46
2003 Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT. Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. Journal of Molecular Biology. 332: 795-808. PMID 12972252 DOI: 10.1016/S0022-2836(03)00927-6  0.401
2003 Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 100: 9831-6. PMID 12900507 DOI: 10.1073/Pnas.1734009100  0.62
2003 Ferrão-Gonzales AD, Palmieri L, Valory M, Silva JL, Lashuel H, Kelly JW, Foguel D. Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of Molecular Biology. 328: 963-74. PMID 12729768 DOI: 10.1016/S0022-2836(03)00368-1  0.55
2002 Wang L, Lashuel HA, Walz T, Colon W. Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proceedings of the National Academy of Sciences of the United States of America. 99: 15947-52. PMID 12456883 DOI: 10.1073/Pnas.252508399  0.677
2002 Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 111: 209-18. PMID 12408865 DOI: 10.1016/S0092-8674(02)01012-7  0.318
2002 Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. Journal of Molecular Biology. 322: 1089-102. PMID 12367530 DOI: 10.1016/S0022-2836(02)00735-0  0.388
2002 Lashuel HA, Hartley DM, Balakhaneh D, Aggarwal A, Teichberg S, Callaway DJ. New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease. The Journal of Biological Chemistry. 277: 42881-90. PMID 12167652 DOI: 10.1074/Jbc.M206593200  0.337
2002 Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 418: 291. PMID 12124613 DOI: 10.1038/418291A  0.482
2002 Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sachettinni J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of Medicinal Chemistry. 45: 321-32. PMID 11784137 DOI: 10.1021/Jm010257N  0.757
2000 Lashuel HA, Labrenz SR, Woo L, Serpell LC, Kelly JW. Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly:  implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 122: 5262-77. PMID 22339465 DOI: 10.1021/Ja9937831  0.545
2000 Cingolani G, Lashuel HA, Gerace L, Müller CW. Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. Febs Letters. 484: 291-8. PMID 11078895 DOI: 10.1016/S0014-5793(00)02154-2  0.319
2000 Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Structural Biology. 7: 754-7. PMID 10966644 DOI: 10.1038/78980  0.559
1999 Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 38: 13560-73. PMID 10521263 DOI: 10.1021/Bi991021C  0.558
1999 Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & Medicinal Chemistry. 7: 39-59. PMID 10199655 DOI: 10.1016/S0968-0896(98)00222-3  0.502
1998 Lashuel HA, Lai Z, Kelly JW. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 37: 17851-64. PMID 9922152 DOI: 10.1021/Bi981876+  0.574
1998 Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/Bi981733N  0.5
1998 Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/Pnas.95.22.12956  0.773
1998 Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification. 14: 31-7. PMID 9758748 DOI: 10.1006/Prep.1998.0944  0.505
1997 Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in Protein Chemistry. 50: 161-81. PMID 9338081 DOI: 10.1016/S0065-3233(08)60321-6  0.751
1997 Lai Z, McCulloch J, Lashuel HA, Kelly JW. Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 36: 10230-9. PMID 9254621 DOI: 10.1021/Bi963195P  0.513
1996 Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 93: 15051-6. PMID 8986762 DOI: 10.1073/Pnas.93.26.15051  0.611
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