Hilal A. Lashuel, Ph. D. - Publications

Molecular and Chemical Biology École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lashuel HA, Novello S. Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein. Neurobiology of Disease. 105417. PMID 34102275 DOI: 10.1016/j.nbd.2021.105417  0.72
2020 Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, Gazit E, Hamley IW, Davis TP, Fändrich M, Otzen DE, Chapman MR, Dobson CM, Eisenberg DS, Mezzenga R. Half a century of amyloids: past, present and future. Chemical Society Reviews. PMID 32632432 DOI: 10.1039/C9Cs00199A  0.36
2016 Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Semisynthetic and in vitro phosphorylation of alpha-synuclein at Y39 promotes functional partly-helical membrane-bound states resembling those induced by PD mutations. Acs Chemical Biology. PMID 27356045 DOI: 10.1021/Acschembio.6B00539  0.64
2016 Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman VL, Masliah E, Lashuel HA. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839406 DOI: 10.1073/Pnas.1512876113  0.64
2016 Fauvet B, Lashuel HA. Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein. Methods in Molecular Biology (Clifton, N.J.). 1345: 3-20. PMID 26453202 DOI: 10.1007/978-1-4939-2978-8_1  0.64
2015 Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, Reynolds NP, Lashuel HA, Mezzenga R. Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angewandte Chemie (International Ed. in English). PMID 26636567 DOI: 10.1002/Anie.201508968  0.64
2015 Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA. Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. Plos One. 10: e0140880. PMID 26484876 DOI: 10.1371/Journal.Pone.0140880  0.64
2015 Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA. Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death. Cell Death and Differentiation. PMID 26138444 DOI: 10.1038/Cdd.2015.79  0.64
2015 Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A. Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on Threonine 3 and regulation by IKKβ. Biochemical and Biophysical Research Communications. PMID 26106822 DOI: 10.1016/J.Bbrc.2015.06.116  0.64
2015 Burai R, Ait-Bouziad N, Chiki A, Lashuel HA. Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. Journal of the American Chemical Society. 137: 5041-52. PMID 25768729 DOI: 10.1021/Ja5131726  0.64
2015 Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of Biological Chemistry. 290: 9412-27. PMID 25657004 DOI: 10.1074/Jbc.M114.610774  0.64
2015 Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G. Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization. Angewandte Chemie (International Ed. in English). 54: 2462-6. PMID 25588987 DOI: 10.1002/Anie.201409050  0.64
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 85: 76-87. PMID 25533483 DOI: 10.1016/J.Neuron.2014.11.027  0.64
2015 Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA. Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiology of Disease. 74: 144-57. PMID 25173807 DOI: 10.1016/J.Nbd.2014.08.017  0.64
2015 Droste P, Frenzel A, Steinwand M, Pelat T, Thullier P, Hust M, Lashuel H, Dübel S. Structural differences of amyloid-β fibrils revealed by antibodies from phage display Bmc Biotechnology. 15. DOI: 10.1186/S12896-015-0146-8  0.64
2014 Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity. The Journal of Biological Chemistry. 289: 21856-76. PMID 24936070 DOI: 10.1074/Jbc.M114.553297  0.64
2014 Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human Molecular Genetics. 23: 4491-509. PMID 24728187 DOI: 10.1093/Hmg/Ddu165  0.64
2014 Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA. One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease. Angewandte Chemie (International Ed. in English). 53: 1928-33. PMID 24446188 DOI: 10.1002/Anie.201307510  0.64
2014 Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Human Molecular Genetics. 23: 2858-79. PMID 24412932 DOI: 10.1093/Hmg/Ddt674  0.64
2013 Fournier M, Roux A, Garrigue J, Muriel MP, Blanche P, Lashuel HA, Anderson JP, Barbour R, Huang J, du Montcel ST, Brice A, Corti O. Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice. Bmc Neuroscience. 14: 135. PMID 24192137 DOI: 10.1186/1471-2202-14-135  0.64
2013 Santi S, Musi V, Descrovi E, Paeder V, Di Francesco J, Hvozdara L, van der Wal P, Lashuel HA, Pastore A, Neier R, Herzig HP. Real-time amyloid aggregation monitoring with a photonic crystal-based approach. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 14: 3476-82. PMID 24105966 DOI: 10.1002/Cphc.201300633  0.64
2013 Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A. Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 110: 17726-31. PMID 24043770 DOI: 10.1073/Pnas.1315654110  0.64
2013 Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA. One-pot total chemical synthesis of human α-synuclein. Chemical Communications (Cambridge, England). 49: 9254-6. PMID 23995579 DOI: 10.1039/C3Cc45353G  0.64
2013 Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: E3945-54. PMID 23983262 DOI: 10.1073/Pnas.1309991110  0.64
2013 Schmid AW, Fauvet B, Moniatte M, Lashuel HA. Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies. Molecular & Cellular Proteomics : McP. 12: 3543-58. PMID 23966418 DOI: 10.1074/Mcp.R113.032730  0.64
2013 Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M. Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of Neurochemistry. 125: 491-511. PMID 23452040 DOI: 10.1111/Jnc.12226  0.64
2013 Jeong JS, Ansaloni A, Mezzenga R, Lashuel HA, Dietler G. Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation. Journal of Molecular Biology. 425: 1765-81. PMID 23415897 DOI: 10.1016/J.Jmb.2013.02.005  0.64
2013 Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nature Reviews. Neuroscience. 14: 38-48. PMID 23254192 DOI: 10.1038/Nrn3406  0.64
2013 Wang ZM, Lashuel HA. Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity. Angewandte Chemie (International Ed. in English). 52: 562-7. PMID 23148019 DOI: 10.1002/Anie.201206561  0.64
2012 El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H. Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket Plos One. 7. PMID 23028743 DOI: 10.1371/Journal.Pone.0045024  0.64
2012 Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Molecular Cell. 48: 87-97. PMID 22902562 DOI: 10.1016/J.Molcel.2012.07.011  0.64
2012 Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, ... ... Lashuel HA, et al. Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. The Journal of Biological Chemistry. 287: 34786-800. PMID 22891248 DOI: 10.1074/Jbc.M112.357665  0.64
2012 Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH. Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction. Biochemical and Biophysical Research Communications. 424: 597-603. PMID 22776201 DOI: 10.1016/J.Bbrc.2012.06.159  0.64
2012 Fauvet B, Fares MB, Samuel F, Dikiy I, Tandon A, Eliezer D, Lashuel HA. Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein. The Journal of Biological Chemistry. 287: 28243-62. PMID 22718772 DOI: 10.1074/Jbc.M112.383711  0.64
2012 Adamcik J, Lara C, Usov I, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA, Hamley IW, Mezzenga R. Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale. 4: 4426-9. PMID 22688679 DOI: 10.1039/C2Nr30768E  0.64
2012 Yang B, Sun X, Lashuel H, Zhang Y. Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons Neuroscience Bulletin. 28: 233-239. PMID 22622822 DOI: 10.1007/S12264-012-1239-1  0.64
2012 Jan A, Lashuel HA. Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches. Methods in Molecular Biology (Clifton, N.J.). 849: 227-43. PMID 22528094 DOI: 10.1007/978-1-61779-551-0_16  0.64
2012 Butterfield S, Hejjaoui M, Fauvet B, Awad L, Lashuel HA. Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity. Journal of Molecular Biology. 421: 204-36. PMID 22342932 DOI: 10.1016/J.Jmb.2012.01.051  0.64
2012 Hejjaoui M, Butterfield S, Fauvet B, Vercruysse F, Cui J, Dikiy I, Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA. Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. Journal of the American Chemical Society. 134: 5196-210. PMID 22339654 DOI: 10.1021/Ja210866J  0.64
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, ... ... Lashuel HA, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/Jbc.M111.318949  0.64
2012 Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA. Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1536-44. PMID 22302797 DOI: 10.1523/Jneurosci.3784-11.2012  0.64
2011 Lu Y, Prudent M, Fauvet B, Lashuel HA, Girault HH. Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. Acs Chemical Neuroscience. 2: 667-75. PMID 22860160 DOI: 10.1021/Cn200074D  0.64
2011 Lashuel HA, Al-Delaimy WK. Arab world needs its science diaspora. Nature. 472: 418. PMID 21525914 DOI: 10.1038/472418D  0.64
2011 Siman P, Blatt O, Moyal T, Danieli T, Lebendiker M, Lashuel HA, Friedler A, Brik A. Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European Journal of Chemical Biology. 12: 1097-104. PMID 21488138 DOI: 10.1002/Cbic.201100033  0.64
2011 Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PJ, Pfeifer A, Muhs A, Lashuel HA. Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. The Journal of Biological Chemistry. 286: 8585-96. PMID 21156804 DOI: 10.1074/Jbc.M110.172411  0.64
2011 Hejjaoui M, Haj-Yahya M, Kumar KS, Brik A, Lashuel HA. Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. Angewandte Chemie (International Ed. in English). 50: 405-9. PMID 21154793 DOI: 10.1002/Anie.201005546  0.64
2011 Braga CA, Follmer C, Palhano FL, Khattar E, Freitas MS, Romão L, Di Giovanni S, Lashuel HA, Silva JL, Foguel D. The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species. Journal of Molecular Biology. 405: 254-73. PMID 21050861 DOI: 10.1016/J.Jmb.2010.10.027  0.64
2011 Conboy L, Varea E, Castro JE, Sakouhi-Ouertatani H, Calandra T, Lashuel HA, Sandi C. Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. Molecular Psychiatry. 16: 533-47. PMID 20177408 DOI: 10.1038/Mp.2010.15  0.64
2010 Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck G, Lashuel HA, Moussa CE. Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Molecular Neurodegeneration. 5: 47. PMID 21050448 DOI: 10.1186/1750-1326-5-47  0.64
2010 Hinault MP, Cuendet AF, Mattoo RU, Mensi M, Dietler G, Lashuel HA, Goloubinoff P. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of Biological Chemistry. 285: 38173-82. PMID 20847048 DOI: 10.1074/Jbc.M110.127753  0.64
2010 Oueslati A, Fournier M, Lashuel HA. Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. Progress in Brain Research. 183: 115-45. PMID 20696318 DOI: 10.1016/S0079-6123(10)83007-9  0.64
2010 El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA. An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorganic & Medicinal Chemistry. 18: 5425-40. PMID 20639113 DOI: 10.1016/J.Bmc.2010.05.010  0.64
2010 Butterfield SM, Lashuel HA. Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. Angewandte Chemie (International Ed. in English). 49: 5628-54. PMID 20623810 DOI: 10.1002/Anie.200906670  0.64
2010 Jan A, Hartley DM, Lashuel HA. Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nature Protocols. 5: 1186-209. PMID 20539293 DOI: 10.1038/Nprot.2010.72  0.64
2010 Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA. Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. The Journal of Biological Chemistry. 285: 26581-98. PMID 20516071 DOI: 10.1074/Jbc.M110.113951  0.64
2010 Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. Journal of Biomolecular Screening. 15: 347-58. PMID 20231420 DOI: 10.1177/1087057110363825  0.64
2010 Allaman I, Gavillet M, Bélanger M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ. Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3326-38. PMID 20203192 DOI: 10.1523/Jneurosci.5098-09.2010  0.64
2010 Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, ... ... Lashuel HA, et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3184-98. PMID 20203178 DOI: 10.1523/Jneurosci.5922-09.2010  0.64
2010 Di Giovanni S, Eleuteri S, Paleologou KE, Yin G, Zweckstetter M, Carrupt PA, Lashuel HA. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. The Journal of Biological Chemistry. 285: 14941-54. PMID 20150427 DOI: 10.1074/Jbc.M109.080390  0.64
2010 Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Phosphorylation of synucleins by members of the Polo-like kinase family. The Journal of Biological Chemistry. 285: 2807-22. PMID 19889641 DOI: 10.1074/Jbc.M109.081950  0.64
2010 Grimminger-Marquardt V, Lashuel HA. Structure and function of the molecular chaperone Hsp104 from yeast. Biopolymers. 93: 252-76. PMID 19768774 DOI: 10.1002/Bip.21301  0.64
2009 Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S, Fernandez CO, Lashuel HA, Benz R, Lange A, Zweckstetter M. Structural properties of pore-forming oligomers of alpha-synuclein. Journal of the American Chemical Society. 131: 17482-9. PMID 19888725 DOI: 10.1021/Ja9077599  0.64
2009 Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A. Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 48: 8090-4. PMID 19780082 DOI: 10.1002/Anie.200902936  0.64
2009 Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Roger T, Le Roy D, Karpinar DP, Leng L, Bucala R, Zweckstetter M, Calandra T, Lashuel HA. A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry. 48: 9858-70. PMID 19737008 DOI: 10.1021/Bi900957E  0.64
2009 Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, ... Lashuel HA, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. Plos One. 4: e6629. PMID 19680561 DOI: 10.1371/Journal.Pone.0006629  0.64
2009 Lashuel HA, Pappu RV. Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies. Chembiochem : a European Journal of Chemical Biology. 10: 1951-4. PMID 19598186 DOI: 10.1002/Cbic.200900373  0.64
2009 Camus MS, Mimna R, Schmid A, Chandravarkar A, Tuchscherer G, Lashuel HA, Mutter M. Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Advances in Experimental Medicine and Biology. 611: 281-2. PMID 19400193 DOI: 10.1007/978-0-387-73657-0_126  0.64
2009 Rospigliosi CC, McClendon S, Schmid AW, Ramlall TF, Barré P, Lashuel HA, Eliezer D. E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. Journal of Molecular Biology. 388: 1022-32. PMID 19345692 DOI: 10.1016/J.Jmb.2009.03.065  0.64
2009 Schmid AW, Chiappe D, Pignat V, Grimminger V, Hang I, Moniatte M, Lashuel HA. Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 284: 13128-42. PMID 19164286 DOI: 10.1074/Jbc.M809067200  0.64
2008 Nepomniaschiy N, Grimminger V, Cohen A, DiGiovanni S, Lashuel HA, Brik A. Switch peptide via Staudinger reaction. Organic Letters. 10: 5243-6. PMID 18959426 DOI: 10.1021/Ol802268E  0.64
2008 Herrera FE, Chesi A, Paleologou KE, Schmid A, Munoz A, Vendruscolo M, Gustincich S, Lashuel HA, Carloni P. Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. Plos One. 3: e3394. PMID 18852892 DOI: 10.1371/Journal.Pone.0003394  0.64
2008 Arimon M, Grimminger V, Sanz F, Lashuel HA. Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils. Journal of Molecular Biology. 384: 1157-73. PMID 18851977 DOI: 10.1016/J.Jmb.2008.09.063  0.64
2008 El-Turk F, Cascella M, Ouertatani-Sakouhi H, Narayanan RL, Leng L, Bucala R, Zweckstetter M, Rothlisberger U, Lashuel HA. The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. Biochemistry. 47: 10740-56. PMID 18795803 DOI: 10.1021/Bi800603X  0.64
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/Jci35781  0.64
2008 Jan A, Gokce O, Luthi-Carter R, Lashuel HA. The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. The Journal of Biological Chemistry. 283: 28176-89. PMID 18694930 DOI: 10.1074/Jbc.M803159200  0.64
2008 Camus MS, Dos Santos S, Chandravarkar A, Mandal B, Schmid AW, Tuchscherer G, Mutter M, Lashuel HA. Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents. Chembiochem : a European Journal of Chemical Biology. 9: 2104-12. PMID 18683159 DOI: 10.1002/Cbic.200800245  0.64
2008 Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA. Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. The Journal of Biological Chemistry. 283: 16895-905. PMID 18343814 DOI: 10.1074/Jbc.M800747200  0.64
2007 Chafekar SM, Malda H, Merkx M, Meijer EW, Viertl D, Lashuel HA, Baas F, Scheper W. Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation. Chembiochem : a European Journal of Chemical Biology. 8: 1857-64. PMID 17763487 DOI: 10.1002/Cbic.200700338  0.64
2007 Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT. The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry. 46: 7107-18. PMID 17530780 DOI: 10.1021/Bi7000246  0.64
2007 Mimna R, Camus MS, Schmid A, Tuchscherer G, Lashuel HA, Mutter M. Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept. Angewandte Chemie (International Ed. in English). 46: 2681-4. PMID 17330907 DOI: 10.1002/Anie.200603681  0.64
2007 Follmer C, Romão L, Einsiedler CM, Porto TC, Lara FA, Moncores M, Weissmüller G, Lashuel HA, Lansbury P, Neto VM, Silva JL, Foguel D. Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein. Biochemistry. 46: 472-82. PMID 17209557 DOI: 10.1021/Bi061871+  0.64
2007 Tuchscherer G, Chandravarkar A, Camus MS, Bérard J, Murat K, Schmid A, Mimna R, Lashuel HA, Mutter M. Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Biopolymers. 88: 239-52. PMID 17206626 DOI: 10.1002/Bip.20663  0.64
2006 Lashuel HA, Hirling H. Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease. Acs Chemical Biology. 1: 420-4. PMID 17168518 DOI: 10.1021/Cb600331E  0.64
2006 Lashuel HA, Zawia N. Islam: governments need to reform education and build a scientific culture. Nature. 444: 545. PMID 17136071 DOI: 10.1038/444545A  0.64
2006 Lansbury PT, Lashuel HA. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature. 443: 774-9. PMID 17051203 DOI: 10.1038/Nature05290  0.64
2006 Lashuel HA, Lansbury PT. Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Quarterly Reviews of Biophysics. 39: 167-201. PMID 16978447 DOI: 10.1017/S0033583506004422  0.64
2006 Saucède L, Dos Santos S, Chandravarkar A, Mandal B, Mimna R, Murat K, Camus MS, Bérard J, Grouzmann E, Adrian M, Dubochet J, Lopez J, Lashuel H, Tuchscherer G, Mutter M. Switch-peptides: From conformational studies to Alzheimer's disease Chimia. 60: 199-202. DOI: 10.2533/000942906777674921  0.64
2005 Lashuel HA, Aljabari B, Sigurdsson EM, Metz CN, Leng L, Callaway DJ, Bucala R. Amyloid fibril formation by macrophage migration inhibitory factor. Biochemical and Biophysical Research Communications. 338: 973-80. PMID 16286092 DOI: 10.1016/J.Bbrc.2005.10.040  0.64
2005 Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH. Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2083-4. PMID 16230335 DOI: 10.1096/Fj.05-4375Fje  0.64
2005 Wang L, Lashuel HA, Colón W. From hexamer to amyloid: marginal stability of apolipoprotein SAA2.2 leads to in vitro fibril formation at physiological temperature. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 139-48. PMID 16194868 DOI: 10.1080/13506120500223084  0.64
2005 Lashuel HA. Membrane permeabilization: a common mechanism in protein-misfolding diseases. Science of Aging Knowledge Environment : Sage Ke. 2005: pe28. PMID 16186179 DOI: 10.1126/Sageke.2005.38.Pe28  0.64
2005 Lashuel HA, Wall JS. Molecular electron microscopy approaches to elucidating the mechanisms of protein fibrillogenesis. Methods in Molecular Biology (Clifton, N.J.). 299: 81-101. PMID 15980597 DOI: 10.1385/1-59259-874-9:081  0.64
2005 Lashuel HA, Grillo-Bosch D. In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein. Methods in Molecular Biology (Clifton, N.J.). 299: 19-33. PMID 15980593 DOI: 10.1385/1-59259-874-9:019  0.64
2005 Morikawa M, Fryer JD, Sullivan PM, Christopher EA, Wahrle SE, DeMattos RB, O'Dell MA, Fagan AM, Lashuel HA, Walz T, Asai K, Holtzman DM. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiology of Disease. 19: 66-76. PMID 15837562 DOI: 10.1016/J.Nbd.2004.11.005  0.64
2005 Cox DL, Lashuel H, Lee KYC, Singh RRR. The materials science of protein aggregation Mrs Bulletin. 30: 452-457. DOI: 10.1557/Mrs2005.123  0.64
2004 Nakagawa T, Futai K, Lashuel HA, Lo I, Okamoto K, Walz T, Hayashi Y, Sheng M. Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron. 44: 453-67. PMID 15504326 DOI: 10.1016/J.Neuron.2004.10.012  0.64
2004 Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of Molecular Neuroscience : Mn. 23: 23-34. PMID 15126689 DOI: 10.1385/Jmn:23:1-2:023  0.64
2003 Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society. 125: 15359-65. PMID 14664580 DOI: 10.1021/Ja0349296  0.64
2003 Kheterpal I, Lashuel HA, Hartley DM, Walz T, Lansbury PT, Wetzel R. Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. Biochemistry. 42: 14092-8. PMID 14640676 DOI: 10.1021/Bi0357816  0.64
2003 Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & Biology. 10: 837-46. PMID 14522054 DOI: 10.1016/J.Chembiol.2003.08.010  0.64
2003 Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT. Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. Journal of Molecular Biology. 332: 795-808. PMID 12972252 DOI: 10.1016/S0022-2836(03)00927-6  0.64
2003 Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 100: 9831-6. PMID 12900507 DOI: 10.1073/Pnas.1734009100  0.64
2003 Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 51-61. PMID 12762144 DOI: 10.3109/13506120308995259  0.64
2003 Ferrão-Gonzales AD, Palmieri L, Valory M, Silva JL, Lashuel H, Kelly JW, Foguel D. Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of Molecular Biology. 328: 963-74. PMID 12729768 DOI: 10.1016/S0022-2836(03)00368-1  0.64
2002 Wang L, Lashuel HA, Walz T, Colon W. Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proceedings of the National Academy of Sciences of the United States of America. 99: 15947-52. PMID 12456883 DOI: 10.1073/Pnas.252508399  0.64
2002 Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 111: 209-18. PMID 12408865 DOI: 10.1016/S0092-8674(02)01012-7  0.64
2002 Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. Journal of Molecular Biology. 322: 1089-102. PMID 12367530 DOI: 10.1016/S0022-2836(02)00735-0  0.64
2002 Lashuel HA, Hartley DM, Balakhaneh D, Aggarwal A, Teichberg S, Callaway DJ. New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease. The Journal of Biological Chemistry. 277: 42881-90. PMID 12167652 DOI: 10.1074/Jbc.M206593200  0.64
2002 Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 418: 291. PMID 12124613 DOI: 10.1038/418291A  0.64
2002 Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sachettinni J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of Medicinal Chemistry. 45: 321-32. PMID 11784137 DOI: 10.1021/Jm010257N  0.64
2000 Lashuel HA, Labrenz SR, Woo L, Serpell LC, Kelly JW. Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly:  implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 122: 5262-77. PMID 22339465 DOI: 10.1021/Ja9937831  0.64
2000 Cingolani G, Lashuel HA, Gerace L, Müller CW. Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. Febs Letters. 484: 291-8. PMID 11078895 DOI: 10.1016/S0014-5793(00)02154-2  0.64
2000 Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Structural Biology. 7: 754-7. PMID 10966644 DOI: 10.1038/78980  0.64
1999 Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 38: 13560-73. PMID 10521263 DOI: 10.1021/Bi991021C  0.64
1999 Atkins AR, Osborne MJ, Lashuel HA, Edelman GM, Wright PE, Cunningham BA, Dyson HJ. Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM. Febs Letters. 451: 162-8. PMID 10371158 DOI: 10.1016/S0014-5793(99)00554-2  0.64
1999 Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & Medicinal Chemistry. 7: 39-59. PMID 10199655 DOI: 10.1016/S0968-0896(98)00222-3  0.64
1998 Lashuel HA, Lai Z, Kelly JW. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 37: 17851-64. PMID 9922152 DOI: 10.1021/Bi981876+  0.64
1998 Hengst L, Göpfert U, Lashuel HA, Reed SI. Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). Genes & Development. 12: 3882-8. PMID 9869641  0.64
1998 Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/Bi981733N  0.64
1998 Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/Pnas.95.22.12956  0.64
1998 Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification. 14: 31-7. PMID 9758748 DOI: 10.1006/Prep.1998.0944  0.64
1997 Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in Protein Chemistry. 50: 161-81. PMID 9338081 DOI: 10.1016/S0065-3233(08)60321-6  0.64
1997 Zeng X, Zhu H, Lashuel HA, Hu JC. Oligomerization properties of GCN4 leucine zipper e and g position mutants. Protein Science : a Publication of the Protein Society. 6: 2218-26. PMID 9336844 DOI: 10.1002/Pro.5560061016  0.64
1997 Lai Z, McCulloch J, Lashuel HA, Kelly JW. Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 36: 10230-9. PMID 9254621 DOI: 10.1021/Bi963195P  0.64
1996 Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 93: 15051-6. PMID 8986762 DOI: 10.1073/Pnas.93.26.15051  0.64
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