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Laura Segatori, Ph.D. - Publications

Affiliations: 
Chemical and Biomolecular Engineering Rice University, Houston, TX 
Area:
Protein folding and misfolding
Website:
http://chbe.rice.edu/Content.aspx?id=70
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Maynard JA, Segatori L. Editorial overview: Tissue, cell, and pathway engineering: Recent innovations in biomedical technologies. Current Opinion in Biotechnology. 83: 102981. PMID 37591033 DOI: 10.1016/j.copbio.2023.102981  0.488
2020 Whitehead TA, Banta S, Bentley WE, Betenbaugh MJ, Chan C, Clark DS, Hoesli CA, Jewett MC, Junker B, Koffas M, Kshirsagar R, Lewis A, Li CT, Maranas C, Terry Papoutsakis E, ... ... Segatori L, et al. The Importance and Future of Biochemical Engineering. Biotechnology and Bioengineering. PMID 32343367 DOI: 10.1002/Bit.27364  0.311
2020 Origel Marmolejo CA, Bachhav B, Patibandla SD, Yang AL, Segatori L. A gene signal amplifier platform for monitoring the unfolded protein response. Nature Chemical Biology. PMID 32152542 DOI: 10.1038/S41589-020-0497-X  0.304
2019 Zeng Y, Bachhav B, Zhao W, Nguyen T, Segatori L. A hysteretic genetic circuit for detection of proteasomal degradation in mammalian cells. Acs Synthetic Biology. PMID 31415719 DOI: 10.1021/Acssynbio.9B00074  0.306
2019 Atkinson JT, Wu B, Segatori L, Silberg JJ. Overcoming component limitations in synthetic biology through transposon-mediated protein engineering. Methods in Enzymology. 621: 191-212. PMID 31128779 DOI: 10.1016/Bs.Mie.2019.02.014  0.428
2019 Zhao W, Bachhav B, McWhite C, Segatori L. A yeast selection system for the detection of proteasomal activation. Protein Engineering, Design & Selection : Peds. PMID 30989230 DOI: 10.1093/Protein/Gzz006  0.431
2018 di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, et al. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nature Cell Biology. PMID 30397314 DOI: 10.1038/S41556-018-0228-7  0.373
2018 Zeng Y, Jones AM, Thomas EE, Nassif B, Silberg JJ, Segatori L. A split transcriptional repressor that links protein solubility to an orthogonal genetic circuit. Acs Synthetic Biology. PMID 30089365 DOI: 10.1021/Acssynbio.8B00129  0.381
2018 Ohata J, Zeng Y, Segatori L, Ball ZT. A Naturally Encoded Dipeptide Handle for Bioorthogonal Chan-Lam Coupling. Angewandte Chemie (International Ed. in English). PMID 29417733 DOI: 10.1002/Anie.201800828  0.334
2017 Zhao W, Pferdehirt L, Segatori L. Quantitatively predictable control of cellular protein levels through proteasomal degradation. Acs Synthetic Biology. PMID 29061039 DOI: 10.1021/Acssynbio.7B00325  0.362
2017 Popp L, Gomez E, Orji W, Ho M, Suh J, Segatori L. TFEB-mediated activation of the lysosome-autophagy system affects the transduction efficiency of adeno-associated virus 2. Virology. 510: 1-8. PMID 28688268 DOI: 10.1016/J.Virol.2017.06.030  0.323
2016 Pandey N, Kuypers BE, Nassif B, Thomas EE, Alnahhas RN, Segatori L, Silberg JJ. Tolerance of a Knotted Near-Infrared Fluorescent Protein to Random Circular Permutation. Biochemistry. 55: 3763-73. PMID 27304983 DOI: 10.1021/Acs.Biochem.6B00258  0.337
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Segatori L, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.314
2015 Popp L, Segatori L. Differential autophagic responses to nano-sized materials. Current Opinion in Biotechnology. 36: 129-136. PMID 26340102 DOI: 10.1016/J.Copbio.2015.08.016  0.329
2015 Kilpatrick K, Zeng Y, Hancock T, Segatori L. Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein. Plos One. 10: e0120819. PMID 25790376 DOI: 10.1371/Journal.Pone.0120819  0.324
2014 Segatori L. Impairment of homeostasis in lysosomal storage disorders. Iubmb Life. 66: 472-7. PMID 25044960 DOI: 10.1002/Iub.1288  0.321
2014 Zhao W, Bonem M, McWhite C, Silberg JJ, Segatori L. Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit. Nature Communications. 5: 3612. PMID 24710080 DOI: 10.1038/Ncomms4612  0.307
2014 Song W, Wang F, Lotfi P, Sardiello M, Segatori L. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. The Journal of Biological Chemistry. 289: 10211-22. PMID 24558044 DOI: 10.1074/Jbc.M113.506246  0.362
2013 Mauri V, Lotfi P, Segatori L, Sardiello M. A rapid and sensitive method for measuring N-acetylglucosaminidase activity in cultured cells. Plos One. 8: e68060. PMID 23840811 DOI: 10.1371/Journal.Pone.0068060  0.316
2013 Wang F, Segatori L. Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding. Plos One. 8: e61418. PMID 23620750 DOI: 10.1371/Journal.Pone.0061418  0.458
2013 Song W, Wang F, Savini M, Ake A, di Ronza A, Sardiello M, Segatori L. TFEB regulates lysosomal proteostasis. Human Molecular Genetics. 22: 1994-2009. PMID 23393155 DOI: 10.1093/Hmg/Ddt052  0.491
2012 Cook NP, Kilpatrick K, Segatori L, Martí AA. Detection of α-synuclein amyloidogenic aggregates in vitro and in cells using light-switching dipyridophenazine ruthenium(II) complexes. Journal of the American Chemical Society. 134: 20776-82. PMID 23237404 DOI: 10.1021/Ja3100287  0.32
2012 Kothawala A, Kilpatrick K, Novoa JA, Segatori L. Quantitative analysis of α-synuclein solubility in living cells using split GFP complementation. Plos One. 7: e43505. PMID 22927976 DOI: 10.1371/Journal.Pone.0043505  0.315
2012 Mathieu JM, Wang F, Segatori L, Alvarez PJ. Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase. Biotechnology and Bioengineering. 109: 2409-15. PMID 22447444 DOI: 10.1002/Bit.24506  0.435
2011 Wang F, Song W, Brancati G, Segatori L. Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases. The Journal of Biological Chemistry. 286: 43454-64. PMID 22006919 DOI: 10.1074/Jbc.M111.274332  0.5
2011 Wang F, Chou A, Segatori L. Lacidipine remodels protein folding and Ca 2+ homeostasis in Gaucher's disease fibroblasts: a mechanism to rescue mutant glucocerebrosidase. Chemistry & Biology. 18: 766-76. PMID 21700212 DOI: 10.1016/J.Chembiol.2011.04.008  0.431
2011 Wang F, Agnello G, Sotolongo N, Segatori L. Ca2+ homeostasis modulation enhances the amenability of L444P glucosylcerebrosidase to proteostasis regulation in patient-derived fibroblasts. Acs Chemical Biology. 6: 158-68. PMID 21043486 DOI: 10.1021/Cb100321M  0.425
2008 Arredondo S, Segatori L, Gilbert HF, Georgiou G. De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. The Journal of Biological Chemistry. 283: 31469-76. PMID 18782764 DOI: 10.1074/Jbc.M803346200  0.719
2008 Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 134: 769-81. PMID 18775310 DOI: 10.1016/J.Cell.2008.06.037  0.66
2006 Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. The Journal of Biological Chemistry. 281: 4911-9. PMID 16280324 DOI: 10.1074/Jbc.M505453200  0.71
2005 Georgiou G, Segatori L. Preparative expression of secreted proteins in bacteria: status report and future prospects. Current Opinion in Biotechnology. 16: 538-45. PMID 16095898 DOI: 10.1016/J.Copbio.2005.07.008  0.539
2005 Segatori L, Arredondo S, Georgiau G. De novo engineering of a bacterial disulfide isomerase Aiche Annual Meeting, Conference Proceedings. 8058.  0.666
2004 Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD. Structure of DsbC from Haemophilus influenzae. Acta Crystallographica. Section D, Biological Crystallography. 60: 1512-8. PMID 15333920 DOI: 10.1107/S0907444904014593  0.536
2004 Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways. Proceedings of the National Academy of Sciences of the United States of America. 101: 10018-23. PMID 15220477 DOI: 10.1073/Pnas.0403003101  0.585
2004 Segatori L, Arredondo S, Georgiou G. Structure-function and de novo design of protein disulfide isomerases Aiche Annual Meeting, Conference Proceedings. 8749.  0.678
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