Qinghai Zhang, Ph.D. - Publications

Affiliations: 
Molecular Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Self-assembling membrane mimics
Website:
http://www.scripps.edu/research/faculty/qzhang

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX. Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function. Nucleic Acids Research. PMID 30137487 DOI: 10.1093/nar/gky758  0.44
2017 Shen Y, Cao R, Liu W, Zhou Y, Wu Y, Tan J, Jin M, Zhong J, Zhang Q, Liu J, Zu X. Negative feedback loop between ZBTB7A and TGF-β in breast cancer. Oncology Letters. 14: 1403-1410. PMID 28789356 DOI: 10.3892/ol.2017.6291  0.36
2016 Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, Chen Y, Guan MX. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. The International Journal of Biochemistry & Cell Biology. PMID 27184967 DOI: 10.1016/j.biocel.2016.05.012  0.44
2016 Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. PMID 26982502 DOI: 10.1021/acs.biochem.5b01330  1
2015 Szewczyk P, Tao H, McGrath AP, Villaluz M, Rees SD, Lee SC, Doshi R, Urbatsch IL, Zhang Q, Chang G. Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallographica. Section D, Biological Crystallography. 71: 732-41. PMID 25760620 DOI: 10.1107/S1399004715000978  1
2015 Moeller A, Lee SC, Tao H, Speir JA, Chang G, Urbatsch IL, Potter CS, Carragher B, Zhang Q. Distinct conformational spectrum of homologous multidrug ABC transporters. Structure (London, England : 1993). 23: 450-60. PMID 25661651 DOI: 10.1016/j.str.2014.12.013  1
2015 Wang A, Stout CD, Zhang Q, Johnson EF. Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding. The Journal of Biological Chemistry. 290: 5092-104. PMID 25555909 DOI: 10.1074/jbc.M114.627661  1
2015 Peng L, Mo F, Zhang Q. Cholate-based synthesis of size-tunable cage compounds. The Journal of Organic Chemistry. 80: 1221-8. PMID 25536149 DOI: 10.1021/jo5023734  1
2014 Martinez L, Arnaud O, Henin E, Tao H, Chaptal V, Doshi R, Andrieu T, Dussurgey S, Tod M, Di Pietro A, Zhang Q, Chang G, Falson P. Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein. The Febs Journal. 281: 673-82. PMID 24219411 DOI: 10.1111/febs.12613  1
2013 Tao H, Peng L, Zhang Q. Synthesis of azole-enriched cyclic peptides by a clean solid-phase-based cyclization-cleavage strategy. Acs Combinatorial Science. 15: 447-51. PMID 23962348 DOI: 10.1021/co400071y  1
2013 Tao H, Lee SC, Moeller A, Roy RS, Siu FY, Zimmermann J, Stevens RC, Potter CS, Carragher B, Zhang Q. Engineered nanostructured β-sheet peptides protect membrane proteins. Nature Methods. 10: 759-61. PMID 23817067 DOI: 10.1038/nmeth.2533  1
2013 Marcoux J, Wang SC, Politis A, Reading E, Ma J, Biggin PC, Zhou M, Tao H, Zhang Q, Chang G, Morgner N, Robinson CV. Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump. Proceedings of the National Academy of Sciences of the United States of America. 110: 9704-9. PMID 23690617 DOI: 10.1073/pnas.1303888110  1
2013 Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states. The Journal of Pharmacology and Experimental Therapeutics. 346: 113-20. PMID 23633618 DOI: 10.1124/jpet.113.204776  1
2013 Lee SC, Bennett BC, Hong WX, Fu Y, Baker KA, Marcoux J, Robinson CV, Ward AB, Halpert JR, Stevens RC, Stout CD, Yeager MJ, Zhang Q. Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E1203-11. PMID 23479627 DOI: 10.1073/pnas.1221442110  1
2013 Shah MB, Jang HH, Zhang Q, David Stout C, Halpert JR. X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket. Archives of Biochemistry and Biophysics. 530: 64-72. PMID 23296089 DOI: 10.1016/j.abb.2012.12.016  1
2013 Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis Biochemistry. 52: 355-364. PMID 23276288 DOI: 10.1021/bi301567z  1
2012 Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 51: 7225-38. PMID 22909231 DOI: 10.1021/bi300894z  1
2012 Tao H, Fu Y, Thompson A, Lee SC, Mahoney N, Stevens RC, Zhang Q. Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 11173-81. PMID 22780816 DOI: 10.1021/la3020404  1
2012 Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proceedings of the National Academy of Sciences of the United States of America. 109: E698-704. PMID 22355148 DOI: 10.1073/pnas.1201107109  1
2012 Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. The Febs Journal. 279: 1607-20. PMID 22051155 DOI: 10.1111/j.1742-4658.2011.08411.x  1
2011 Zhang Q, Tao H, Hong WX. New amphiphiles for membrane protein structural biology. Methods (San Diego, Calif.). 55: 318-23. PMID 21958988 DOI: 10.1016/j.ymeth.2011.09.015  1
2011 Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. Molecular Pharmacology. 80: 1047-55. PMID 21875942 DOI: 10.1124/mol.111.074427  1
2011 Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 50: 4903-11. PMID 21510666 DOI: 10.1021/bi200482g  1
2011 Tao H, Weng Y, Zhuo R, Chang G, Urbatsch IL, Zhang Q. Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein. Chembiochem : a European Journal of Chemical Biology. 12: 868-73. PMID 21387512 DOI: 10.1002/cbic.201100048  1
2010 Fu Y, Weng Y, Hong WX, Zhang Q. Efficient Synthesis of Unsaturated 1-Monoacyl Glycerols for in meso Crystallization of Membrane Proteins. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 2011: 809-812. PMID 21461138 DOI: 10.1055/s-0030-1259912  1
2010 Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL, Stout CD, Halpert JR. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. The Journal of Biological Chemistry. 285: 38602-11. PMID 20880847 DOI: 10.1074/jbc.M110.180646  1
2010 He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G. Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature. 467: 991-4. PMID 20861838 DOI: 10.1038/nature09408  1
2010 Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 49: 8709-20. PMID 20815363 DOI: 10.1021/bi100914z  1
2010 Hong WX, Baker KA, Ma X, Stevens RC, Yeager M, Zhang Q. Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir : the Acs Journal of Surfaces and Colloids. 26: 8690-6. PMID 20232919 DOI: 10.1021/la904893d  1
2010 Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Molecular Pharmacology. 77: 529-38. PMID 20061448 DOI: 10.1124/mol.109.062570  1
2010 Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD. Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism. Journal of Molecular Biology. 396: 441-51. PMID 19961857 DOI: 10.1016/j.jmb.2009.11.057  1
2009 Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science (New York, N.Y.). 323: 1718-22. PMID 19325113 DOI: 10.1126/science.1168750  1
2008 Zhang Q, Horst R, Geralt M, Ma X, Hong WX, Finn MG, Stevens RC, Wüthrich K. Microscale NMR screening of new detergents for membrane protein structural biology. Journal of the American Chemical Society. 130: 7357-63. PMID 18479092 DOI: 10.1021/ja077863d  0.36
2007 Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang G. Designing facial amphiphiles for the stabilization of integral membrane proteins. Angewandte Chemie (International Ed. in English). 46: 7023-5. PMID 17691085 DOI: 10.1002/anie.200701556  1
2007 Stewart CR, Wilson LM, Zhang Q, Pham CL, Waddington LJ, Staples MK, Stapleton D, Kelly JW, Howlett GJ. Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation. Biochemistry. 46: 5552-61. PMID 17429947 DOI: 10.1021/bi602554z  1
2006 Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Accounts of Chemical Research. 39: 611-9. PMID 16981677 DOI: 10.1021/ar0500766  1
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/nchembio782  1
2005 Zhang Q, Kelly JW. Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice? Biochemistry. 44: 9079-85. PMID 15966731 DOI: 10.1021/bi050378f  1
2005 Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry. 44: 4977-83. PMID 15794636 DOI: 10.1021/bi0501030  1
2005 Zhang Q, Xu W, Lu X. Cycloisomerization of 1,6-enynes using acetate as a nucleophile under palladium(II) catalysis. The Journal of Organic Chemistry. 70: 1505-7. PMID 15704997 DOI: 10.1021/jo048414o  0.36
2004 Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4752-7. PMID 15034169 DOI: 10.1073/pnas.0400924101  1
2003 Zhang Q, Kelly JW. Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. Biochemistry. 42: 8756-61. PMID 12873136 DOI: 10.1021/bi030077a  1
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