Daryl A. Bosco, Ph.D. - Publications

Affiliations: 
Neurology University of Massachusetts Medical School, Worcester, MA, United States 
Area:
Neurodegeneration ALS
Website:
http://profiles.umassmed.edu/profiles/ProfileDetails.aspx?From=SE&Person=1238

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tischbein M, Baron DM, Lin YC, Gall KV, Landers JE, Fallini C, Bosco DA. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. The Journal of Biological Chemistry. PMID 31092554 DOI: 10.1074/jbc.RA118.005933  0.36
2019 Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA. Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS. Human Molecular Genetics. PMID 30806671 DOI: 10.1093/hmg/ddz048  0.36
2018 Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C. Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30038021 DOI: 10.1073/pnas.1801109115  1
2017 Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Scientific Reports. 7: 115. PMID 28273913 DOI: 10.1038/s41598-017-00091-1  1
2015 Peters OM, Cabrera GT, Tran H, Gendron TF, McKeon JE, Metterville J, Weiss A, Wightman N, Salameh J, Kim J, Sun H, Boylan KB, Dickson D, Kennedy Z, Lin Z, ... ... Bosco DA, et al. Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice. Neuron. 88: 902-909. PMID 26637797 DOI: 10.1016/j.neuron.2015.11.018  1
2015 Boopathy S, Silvas TV, Tischbein M, Jansen S, Shandilya SM, Zitzewitz JA, Landers JE, Goode BL, Schiffer CA, Bosco DA. Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26056300 DOI: 10.1073/pnas.1424108112  1
2014 Ward CL, Boggio KJ, Johnson BN, Boyd JB, Douthwright S, Shaffer SA, Landers JE, Glicksman MA, Bosco DA. A loss of FUS/TLS function leads to impaired cellular proliferation. Cell Death & Disease. 5: e1572. PMID 25501833 DOI: 10.1038/cddis.2014.508  1
2014 Matus S, Bosco DA, Hetz C. Autophagy meets fused in sarcoma-positive stress granules. Neurobiology of Aging. 35: 2832-5. PMID 25444610 DOI: 10.1016/j.neurobiolaging.2014.08.019  1
2014 Sama RR, Ward CL, Bosco DA. Functions of FUS/TLS from DNA repair to stress response: implications for ALS. Asn Neuro. 6. PMID 25289647 DOI: 10.1177/1759091414544472  0.36
2014 Rotunno MS, Auclair JR, Maniatis S, Shaffer SA, Agar J, Bosco DA. Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 289: 28527-38. PMID 25164820 DOI: 10.1074/jbc.M114.581801  1
2014 Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN. Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation. Proteomics. 14: 1152-7. PMID 24634066 DOI: 10.1002/pmic.201300450  1
2013 Rotunno MS, Bosco DA. An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis. Frontiers in Cellular Neuroscience. 7: 253. PMID 24379756 DOI: 10.3389/fncel.2013.00253  1
2013 Baron DM, Kaushansky LJ, Ward CL, Sama RR, Chian RJ, Boggio KJ, Quaresma AJ, Nickerson JA, Bosco DA. Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics. Molecular Neurodegeneration. 8: 30. PMID 24090136 DOI: 10.1186/1750-1326-8-30  1
2013 Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH, Bosco DA, Agar JN. Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. Biochemistry. 52: 6137-44. PMID 23927036 DOI: 10.1021/bi4006122  1
2013 Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, et al. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. Plos One. 8: e65235. PMID 23776455 DOI: 10.1371/journal.pone.0065235  1
2013 Sama RR, Ward CL, Kaushansky LJ, Lemay N, Ishigaki S, Urano F, Bosco DA. FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. Journal of Cellular Physiology. 228: 2222-31. PMID 23625794 DOI: 10.1002/jcp.24395  1
2013 Broering TJ, Wang H, Boatright NK, Wang Y, Baptista K, Shayan G, Garrity KA, Kayatekin C, Bosco DA, Matthews CR, Ambrosino DM, Xu Z, Babcock GJ. Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1. Plos One. 8: e61210. PMID 23613814 DOI: 10.1371/journal.pone.0061210  1
2012 Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, ... ... Bosco DA, et al. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature. 488: 499-503. PMID 22801503 DOI: 10.1038/nature11280  1
2012 Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proceedings of the National Academy of Sciences of the United States of America. 109: 5074-9. PMID 22416121 DOI: 10.1073/pnas.1115402109  1
2011 van Blitterswijk M, Gulati S, Smoot E, Jaffa M, Maher N, Hyman BT, Ivinson AJ, Scherzer CR, Schoenfeld DA, Cudkowicz ME, Brown RH, Bosco DA. Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 430-8. PMID 22023190 DOI: 10.3109/17482968.2011.585163  1
2011 Bosco DA, LaVoie MJ, Petsko GA, Ringe D. Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis. Cold Spring Harbor Perspectives in Biology. 3: a007500. PMID 21844169 DOI: 10.1101/cshperspect.a007500  1
2011 Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S, Ringe D, Petsko GA. A yeast model of FUS/TLS-dependent cytotoxicity. Plos Biology. 9: e1001052. PMID 21541368 DOI: 10.1371/journal.pbio.1001052  1
2011 Ticozzi N, Vance C, Leclerc AL, Keagle P, Glass JD, McKenna-Yasek D, Sapp PC, Silani V, Bosco DA, Shaw CE, Brown RH, Landers JE. Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 285-90. PMID 21438137 DOI: 10.1002/ajmg.b.31158  1
2010 Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nature Neuroscience. 13: 1396-403. PMID 20953194 DOI: 10.1038/nn.2660  1
2010 Bosco DA, Landers JE. Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets. Cns & Neurological Disorders Drug Targets. 9: 779-90. PMID 20942785  1
2010 Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR. Journal of Molecular Biology. 403: 723-38. PMID 20708627 DOI: 10.1016/j.jmb.2010.08.001  1
2010 Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ, Sapp P, McKenna-Yasek D, Brown RH, Hayward LJ. Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Human Molecular Genetics. 19: 4160-75. PMID 20699327 DOI: 10.1093/hmg/ddq335  1
2010 Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Leyva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silani V, Furlong CE, et al. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of Neurology. 68: 102-7. PMID 20582942 DOI: 10.1002/ana.21993  1
2009 Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/JNEUROSCI.3463-09.2009  1
2009 Gao J, Bosco DA, Powers ET, Kelly JW. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins. Nature Structural & Molecular Biology. 16: 684-90. PMID 19525973 DOI: 10.1038/nsmb.1610  1
2009 Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (New York, N.Y.). 323: 1205-8. PMID 19251627 DOI: 10.1126/science.1166066  1
2007 Labeikovsky W, Eisenmesser EZ, Bosco DA, Kern D. Structure and dynamics of pin1 during catalysis by NMR. Journal of Molecular Biology. 367: 1370-81. PMID 17316687 DOI: 10.1016/j.jmb.2007.01.049  1
2006 Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Accounts of Chemical Research. 39: 611-9. PMID 16981677 DOI: 10.1021/ar0500766  1
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/nchembio782  1
2005 Eisenmesser EZ, Millet O, Labeikovsky W, Korzhnev DM, Wolf-Watz M, Bosco DA, Skalicky JJ, Kay LE, Kern D. Intrinsic dynamics of an enzyme underlies catalysis. Nature. 438: 117-21. PMID 16267559 DOI: 10.1038/nature04105  1
2004 Bosco DA, Kern D. Catalysis and binding of cyclophilin A with different HIV-1 capsid constructs. Biochemistry. 43: 6110-9. PMID 15147195 DOI: 10.1021/bi049841z  1
2002 Bosco DA, Eisenmesser EZ, Pochapsky S, Sundquist WI, Kern D. Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proceedings of the National Academy of Sciences of the United States of America. 99: 5247-52. PMID 11929983 DOI: 10.1073/pnas.082100499  1
2002 Eisenmesser EZ, Bosco DA, Akke M, Kern D. Enzyme dynamics during catalysis. Science (New York, N.Y.). 295: 1520-3. PMID 11859194 DOI: 10.1126/science.1066176  1
2000 Kerr KM, Cahoon M, Bosco DA, Hedstrom L. Monovalent cation activation in Escherichia coli inosine 5'-monophosphate dehydrogenase. Archives of Biochemistry and Biophysics. 375: 131-7. PMID 10683258 DOI: 10.1006/abbi.1999.1644  1
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