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Christopher Halbrook - Publications

Affiliations: 
2016- Molecular and Integrative Physiology University of Michigan, Ann Arbor, Ann Arbor, MI 
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Radyk MD, Nelson BS, Halbrook CJ, Wood A, Lavoie B, Salvatore L, Corfas G, Colacino JA, Shah YM, Crawford HC, Lyssiotis CA. Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia. Biorxiv : the Preprint Server For Biology. PMID 37986898 DOI: 10.1101/2023.11.06.565895  0.848
2023 Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee HJ, Dzierozynski LN, ... ... Halbrook CJ, et al. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature. PMID 37198494 DOI: 10.1038/s41586-023-06073-w  0.826
2023 Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Pancreatic cancer: Advances and challenges. Cell. 186: 1729-1754. PMID 37059070 DOI: 10.1016/j.cell.2023.02.014  0.643
2023 Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, ... ... Halbrook CJ, et al. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 12. PMID 36727849 DOI: 10.7554/eLife.80721  0.653
2022 Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, et al. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nature Cancer. 3: 1386-1403. PMID 36411320 DOI: 10.1038/s43018-022-00463-1  0.845
2022 Kerk S, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, ... ... Halbrook CJ, et al. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. Elife. 11. PMID 35815941 DOI: 10.7554/eLife.73245  0.842
2022 Boyer S, Lee HJ, Steele N, Zhang L, Sajjakulnukit P, Andren A, Ward MH, Singh R, Basrur V, Zhang Y, Nesvizhskii AI, Pasca di Magliano M, Halbrook CJ, Lyssiotis CA. Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway. Elife. 11. PMID 35156921 DOI: 10.7554/eLife.73796  0.708
2021 Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, et al. Hyaluronic acid fuels pancreatic cancer cell growth. Elife. 10. PMID 34951587 DOI: 10.7554/eLife.62645  0.828
2021 Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, et al. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nature Communications. 12: 4860. PMID 34381026 DOI: 10.1038/s41467-021-24859-2  0.801
2021 Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metabolism. PMID 33609439 DOI: 10.1016/j.cmet.2021.02.001  0.605
2021 Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu LJ, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, ... ... Halbrook CJ, et al. Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33495315 DOI: 10.1158/1078-0432.CCR-20-3715  0.633
2020 Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications. 11: 3811. PMID 32732914 DOI: 10.1038/S41467-020-17512-X  0.766
2020 Zhou Z, Torres M, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, et al. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science (New York, N.Y.). PMID 32193362 DOI: 10.1126/Science.Aay2494  0.49
2020 Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai V, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, et al. Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis. Cancer Discovery. PMID 31911451 DOI: 10.1158/2159-8290.Cd-19-0958  0.647
2020 Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, ... ... Halbrook CJ, et al. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer & Metabolism. 8: 1. PMID 31908776 DOI: 10.1186/S40170-019-0202-2  0.754
2019 Lanfranca MP, Zhang Y, Girgis A, Kasselman S, Lazarus J, Kryczek I, Delrosario L, Rhim A, Koneva L, Sartor M, Sun L, Halbrook C, Nathan H, Shi J, Crawford HC, et al. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice. Gastroenterology. PMID 31843590 DOI: 10.1053/J.Gastro.2019.12.010  0.431
2019 Halbrook CJ, Wahl DR, Lyssiotis CA. Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer. Trends in Biochemical Sciences. PMID 31699584 DOI: 10.1016/J.Tibs.2019.10.007  0.642
2019 Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. Inhibiting the hexosamine biosynthetic pathway lowers O-GlcNAcylation levels and sensitizes cancer to environmental stress. Biochemistry. PMID 31625393 DOI: 10.1021/Acs.Biochem.9B00560  0.561
2019 Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, et al. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes & Development. PMID 31048544 DOI: 10.1101/Gad.323303.118  0.754
2019 Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metabolism. PMID 30827862 DOI: 10.1016/J.Cmet.2019.02.001  0.783
2019 Halbrook CJ, Nelson BS, Lysstiotis CA. Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors. Cancer Discovery. 9: 326-328. PMID 30824487 DOI: 10.1158/2159-8290.CD-19-0034  0.817
2019 Steele N, Kemp S, Irizarry-Negron V, Sirihorachai V, Abbas A, Carpenter E, Halbrook C, Espinoza C, Lyssiotis C, Crawford H, Frankel T, Bednar F, Allen B, Magliano MPd. Abstract A52: Modulation of Hedgehog signaling alters immune infiltration in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A52  0.687
2019 Menjivar RE, Halbrook C, Velez A, Lima F, Espinoza C, Galban S, Zhang Y, Lyssiotis C, Magliano MPd. Abstract A31: Investigating the effect of myeloid Arg1 deletion on tumor growth and CD8+ T-cell infiltration and activation in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A31  0.676
2019 Steele N, Irizarry-Negron V, Sirihorachai V, Kemp S, Carpenter E, Halbrook C, Lyssiotis C, Bednar F, Frankel T, Allen B, Pasca di Magliano M. 3373 Modulation of Hedgehog Signaling Alters Immune Infiltration in Pancreatic Cancer Journal of Clinical and Translational Science. 3: 16-16. DOI: 10.1017/cts.2019.40  0.65
2018 Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. Metabolism and Epigenetics of Pancreatic Cancer Stem Cells. Seminars in Cancer Biology. PMID 30273655 DOI: 10.1016/J.Semcancer.2018.09.008  0.733
2018 Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cellular and Molecular Gastroenterology and Hepatology. 5: 169-185.e2. PMID 29693047 DOI: 10.1016/J.Jcmgh.2017.10.008  0.377
2018 Halbrook CJ, Nwosu ZC, Lyssiotis CA. Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation. Trends in Endocrinology and Metabolism: Tem. PMID 29692332 DOI: 10.1016/j.tem.2018.04.002  0.603
2018 Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, et al. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. The Journal of Pathology. PMID 29672864 DOI: 10.1002/Path.5085  0.783
2018 Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29543507 DOI: 10.1152/ajpgi.00416.2017  0.646
2018 Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, et al. Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. Jci Insight. 3. PMID 29367463 DOI: 10.1172/Jci.Insight.97422  0.784
2018 Halbrook CJ. 350 - BMI1 Regulates Cellular Metabolism Through HIF Signaling in Pancreatic Cancer Gastroenterology. 154: S-1357. DOI: 10.1016/S0016-5085(18)34440-8  0.454
2017 Halbrook CJ, Lyssiotis CA. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell. 31: 5-19. PMID 28073003 DOI: 10.1016/j.ccell.2016.12.006  0.697
2016 Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, et al. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes & Development. 30: 2669-2683. PMID 28087712 DOI: 10.1101/Gad.291021.116  0.365
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27706144 DOI: 10.1038/nature19851  0.824
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27509858 DOI: 10.1038/Nature19084  0.834
2014 Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 146: 233-44.e5. PMID 23999170 DOI: 10.1053/J.Gastro.2013.08.053  0.379
2012 DelGiorno KE, Takeuchi K, Halbrook C, Crawford HC. Abstract B73: Tumor-associated pancreatic metaplasia assumes a biliary duct-like phenotype. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B73  0.486
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