Gunda I. Georg - Publications

Affiliations: 
Medicinal chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Therapeutics Discovery & Development
Website:
http://www.pharmacy.umn.edu/faculty/georg_gunda/

220 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK. The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10. Open Biology. 9: 190117. PMID 31409229 DOI: 10.1098/rsob.190117  1
2019 Bajorath J, Kearnes S, Walters WP, Georg GI, Wang S. The Future Is Now: Artificial Intelligence in Drug Discovery. Journal of Medicinal Chemistry. PMID 31120741 DOI: 10.1021/acs.jmedchem.9b00805  1
2019 Guengerich FP, Georg GI, Wang S. Drug Metabolism and Toxicology Special Issue Call for Papers. Journal of Medicinal Chemistry. 62: 1077. PMID 30990043 DOI: 10.1021/acs.jmedchem.9b00005  1
2019 Bolognesi ML, Ganamet KL, Liu H, Poulsen SA, Georg GI, Wang S. Women in Medicinal Chemistry Special Issue Call for Papers. Journal of Medicinal Chemistry. PMID 30950604 DOI: 10.1021/acs.jmedchem.9b00534  1
2019 Wang S, Georg GI. A Message from the Editors-in-Chief. Journal of Medicinal Chemistry. PMID 30794406 DOI: 10.1021/acs.jmedchem.9b00235  1
2019 Guengerich FP, Georg GI, Wang S. Drug Metabolism and Toxicology Special Issue Call for Papers. Journal of Medicinal Chemistry. PMID 30633511 DOI: 10.1021/acs.jmedchem.9b00005  1
2018 Paulson CN, Guan X, Ayoub AM, Chan A, Karim RM, Pomerantz WCK, Schönbrunn E, Georg GI, Hawkinson JE. Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe. Acs Medicinal Chemistry Letters. 9: 1223-1229. PMID 30613330 DOI: 10.1021/acsmedchemlett.8b00380  1
2018 Haskell-Luevano C, Georg GI, Wang S, Meanwell N. Allosteric Modulators of Drug Targets Special Issue. Journal of Medicinal Chemistry. PMID 29412672 DOI: 10.1021/acs.jmedchem.8b00171  1
2018 Syeda SS, Sánchez G, Hong KH, Hawkinson JE, Georg GI, Blanco G. Design, Synthesis, in vitro and in vivo Evaluation of Ouabain Analogs as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception. Journal of Medicinal Chemistry. PMID 29291372 DOI: 10.1021/acs.jmedchem.7b00925  1
2017 Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Schönbrunn E. Structural basis of ALDH1A2 inhibition by irreversible and reversible small molecule inhibitors. Acs Chemical Biology. PMID 29240402 DOI: 10.1021/acschembio.7b00685  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Medicinal Chemistry Letters. 8: 379-382. PMID 28435522 DOI: 10.1021/acsmedchemlett.7b00056  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Central Science. 3: 143-147. PMID 28386587 DOI: 10.1021/acscentsci.7b00069  1
2017 Georg GI, Wang S. Current Medicinal Chemistry Research in India: Progress and Opportunities. Journal of Medicinal Chemistry. 60: 1619. PMID 28274124 DOI: 10.1021/acs.jmedchem.7b00317  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Journal of Medicinal Chemistry. PMID 28244745 DOI: 10.1021/acs.jmedchem.7b00229  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Journal of Chemical Information and Modeling. PMID 28244743 DOI: 10.1021/acs.jcim.7b00105  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Biochemistry. PMID 28244742 DOI: 10.1021/acs.biochem.7b00110  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Chemical Neuroscience. PMID 28244737 DOI: 10.1021/acschemneuro.7b00064  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Chemical Biology. PMID 28244728 DOI: 10.1021/acschembio.7b00119  1
2017 Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Infectious Diseases. PMID 28244723 DOI: 10.1021/acsinfecdis.7b00023  1
2016 Syeda SS, Rice D, Hook DJ, Heckert LL, Georg GI. Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes: Unfortunately, in the article. Archiv Der Pharmazie. 349: 572. PMID 27373873 DOI: 10.1002/ardp.201670022  1
2016 Ranade AR, Higgins L, Markowski TW, Glaser N, Kashin D, Bai R, Hong KH, Hamel E, Höfle G, Georg GI. Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin. Journal of Medicinal Chemistry. PMID 26986898 DOI: 10.1021/acs.jmedchem.6b00188  1
2016 Syeda SS, Rice D, Hook DJ, Heckert LL, Georg GI. Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes. Archiv Der Pharmazie. PMID 26948688 DOI: 10.1002/ardp.201500440  1
2016 Shetty J, Sinville R, Shumilin IA, Minor W, Zhang J, Hawkinson JE, Georg GI, Flickinger CJ, Herr JC. Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2. Protein Expression and Purification. PMID 26777341 DOI: 10.1016/j.pep.2016.01.009  1
2016 Zhang Y, Tian D, Matsuyama H, Hamazaki T, Shiratsuchi T, Terada N, Hook DJ, Walters MA, Georg GI, Hawkinson JE. Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. Journal of Biomolecular Screening. PMID 26746582 DOI: 10.1177/1087057115624637  1
2015 Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. Acs Chemical Biology. PMID 26674547 DOI: 10.1021/acschembio.5b00748  1
2015 Gu X, Georg GI. Regioselective C5-alkylation and C5-methylcarbamate formation of 2,3-dihydro-4-pyridones and C3-alkylation and C3-methylcarbamate formation of 4-(pyrrolidin-1-yl)furan-2(5H)-one. Tetrahedron Letters. 56: 5874-5877. PMID 26663985 DOI: 10.1016/j.tetlet.2015.09.004  1
2015 Patil S, Lis LG, Schumacher RJ, Norris BJ, Morgan ML, Cuellar RA, Blazar BR, Suryanarayanan R, Gurvich VJ, Georg GI. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts. Journal of Medicinal Chemistry. PMID 26596892 DOI: 10.1021/acs.jmedchem.5b01329  1
2015 Li W, Schneider CM, Georg GI. Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions. Organic Letters. 17: 3902-5. PMID 26176267 DOI: 10.1021/acs.orglett.5b01892  1
2015 Siegel RA, Kapoor M, Cheryala N, Georg GI, Cloyd JC. Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies. Epilepsy & Behavior : E&B. PMID 26115606 DOI: 10.1016/j.yebeh.2015.05.004  1
2015 Kirtane AR, Wong HL, Guru BR, Lis LG, Georg GI, Gurvich VJ, Panyam J. Reformulating tylocrebrine in EGFR targeted polymeric nanoparticles improves its therapeutic index. Molecular Pharmaceutics. PMID 26065924 DOI: 10.1021/acs.molpharmaceut.5b00173  1
2015 Syeda SS, Jakkaraj S, Georg GI. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tetrahedron Letters. 56: 3354-3457. PMID 26034331 DOI: 10.1016/j.tetlet.2015.02.062  1
2015 Li W, Georg GI. A concise formal total synthesis of lactimidomycin. Chemical Communications (Cambridge, England). 51: 8634-6. PMID 25900419 DOI: 10.1039/c5cc02571k  1
2015 Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schönbrunn E. Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2. Molecules (Basel, Switzerland). 20: 1643-60. PMID 25608045 DOI: 10.3390/molecules20011643  1
2015 Conway SJ, Woster PM, Shen JK, Georg G, Wang S. Epigenetics: novel therapeutics targeting epigenetics. Journal of Medicinal Chemistry. 58: 523-4. PMID 25532017 DOI: 10.1021/jm501941q  1
2014 Seki H, Georg GI. Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component. European Journal of Organic Chemistry. 2014: 3777-3783. PMID 25395879 DOI: 10.1002/ejoc.201402232  1
2014 Cushman M, Georg GI, Holzgrabe U, Wang S. Absolute quantitative (1)h NMR spectroscopy for compound purity determination. Journal of Medicinal Chemistry. 57: 9219. PMID 25380231 DOI: 10.1021/jm501683w  1
2014 Yu YY, Georg GI. Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes. Advanced Synthesis & Catalysis. 356: 1359-1369. PMID 25071423 DOI: 10.1002/adsc.201300904  1
2014 Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, ... ... Georg GI, et al. Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. Journal of Biomolecular Screening. 19: 1201-1211. PMID 24870016 DOI: 10.1177/1087057114536227  1
2014 Ranade AR, Georg GI. Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from β-substituted β-hydroxyaminoaldehydes. The Journal of Organic Chemistry. 79: 984-92. PMID 24785413 DOI: 10.1021/jo402445r  1
2014 Kapoor M, Winter T, Lis L, Georg GI, Siegel RA. Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies. The Aaps Journal. 16: 577-85. PMID 24700272 DOI: 10.1208/s12248-014-9596-5  1
2014 Kim YW, Georg GI. Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis. Organic Letters. 16: 1574-7. PMID 24650204 DOI: 10.1021/ol500105d  1
2014 Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schönbrunn E. Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. Acs Chemical Biology. 9: 1160-71. PMID 24568369 DOI: 10.1021/cb500072z  1
2014 Gilson MK, Georg G, Wang S. Digital chemistry in the Journal of Medicinal Chemistry. Journal of Medicinal Chemistry. 57: 1137. PMID 24521446 DOI: 10.1021/jm5002056  1
2014 Dosa PI, Georg GI, Gurvich VJ, Hawkinson JE, Walters MA, Wong HL. From HTS to Phase I: the Institute for Therapeutics Discovery and Development at the University of Minnesota. Combinatorial Chemistry & High Throughput Screening. 17: 231-40. PMID 24409956 DOI: 10.2174/1386207317666140109122033  1
2014 Seki H, Georg GI. 2,3-dihydropyridin-4(1 H)-ones and 3-aminocyclohex-2-enones: Synthesis, functionalization, and applications to alkaloid synthesis Synlett. 25: 2536-2557. DOI: 10.1055/s-0034-1378529  1
2014 Yu YY, Ranade AR, Georg GI. Transition metal-free direct trifluoromethylation of 2,3-Dihydropyridin-4(1H)-ones at room temperature Advanced Synthesis and Catalysis. 356: 3510-3518. DOI: 10.1002/adsc.201400417  1
2013 Chung SS, Cuellar RA, Wang X, Reczek PR, Georg GI, Wolgemuth DJ. Pharmacological activity of retinoic acid receptor alpha-selective antagonists in vitro and in vivo. Acs Medicinal Chemistry Letters. 4: 446-450. PMID 24040487 DOI: 10.1021/ml300365k  1
2013 Martin MP, Olesen SH, Georg GI, Schönbrunn E. Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. Acs Chemical Biology. 8: 2360-5. PMID 24007471 DOI: 10.1021/cb4003283  1
2013 Yu YY, Bi L, Georg GI. Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. The Journal of Organic Chemistry. 78: 6163-9. PMID 23750615 DOI: 10.1021/jo400830t  1
2013 Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, ... Georg GI, et al. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. Journal of Medicinal Chemistry. 56: 3768-82. PMID 23600925 DOI: 10.1021/jm301234k  1
2013 Hutt OE, Doan TL, Georg GI. Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol. Organic Letters. 15: 1602-5. PMID 23530630 DOI: 10.1021/ol400385w  1
2013 Yu YY, Georg GI. Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C-H activation. Chemical Communications (Cambridge, England). 49: 3694-6. PMID 23529083 DOI: 10.1039/c3cc41130c  1
2013 Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ. High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma. Plos One. 8: e56827. PMID 23451094 DOI: 10.1371/journal.pone.0056827  1
2013 Georg GI, Wang S. Hepatitis C virus (HCV) therapies special thematic issue: call for papers. Journal of Medicinal Chemistry. 56: 387. PMID 23294104 DOI: 10.1021/jm301895h  1
2013 Georg GI, Wang S. Plagiarism Journal of Medicinal Chemistry. 56: 1. DOI: 10.1021/jm301748n  1
2013 Gu X, Georg GI. Lithium perchlorate-, acetic anhydride-, and triphenylphosphine-assisted multicomponent syntheses of 4-unsubstituted 2,5-dioxooctahydroquinoline-3- carboxylates and 3-carbonitriles Tetrahedron. 69: 9406-9416. DOI: 10.1016/j.tet.2013.08.081  1
2012 Kim YW, Niphakis MJ, Georg GI. Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The Journal of Organic Chemistry. 77: 9496-503. PMID 23088256 DOI: 10.1021/jo301531k  1
2012 Chugh R, Sangwan V, Patil SP, Dudeja V, Dawra RK, Banerjee S, Schumacher RJ, Blazar BR, Georg GI, Vickers SM, Saluja AK. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Science Translational Medicine. 4: 156ra139. PMID 23076356 DOI: 10.1126/scitranslmed.3004334  1
2012 Niphakis MJ, Gay BC, Hong KH, Bleeker NP, Georg GI. Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs. Bioorganic & Medicinal Chemistry. 20: 5893-900. PMID 22910225 DOI: 10.1016/j.bmc.2012.07.044  1
2012 Sajjad M, Riaz U, Yao R, Bernacki RJ, Abouzied M, Erb DA, Chaudhary ND, Veith JM, Georg GI, Nabi HA. Investigation of 3'-debenzoyl-3'-(3-([¹²⁴I]-iodobenzoyl))paclitaxel analog as a radio-tracer to study multidrug resistance in vivo. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 70: 1624-31. PMID 22738838 DOI: 10.1016/j.apradiso.2012.03.008  1
2012 Georg GI, Wang S. Alzheimer's disease special thematic issue: call for papers. Journal of Medicinal Chemistry. 55: 2914. PMID 22458443 DOI: 10.1021/jm300393h  1
2012 Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of Organic Chemistry. 77: 3082-98. PMID 22432895 DOI: 10.1021/jo202054g  1
2012 Wang S, Georg GI. Transition in leadership: opportunities and challenges. Journal of Medicinal Chemistry. 55: 1. PMID 22191537 DOI: 10.1021/jm201695q  1
2012 Leighty MW, Spletstoser JT, Georg GI. Mild conversion of tertiary amides to aldehydes using Cp2Zr(H)Cl (Schwartz's reagent) Organic Syntheses. 88: 427-437. DOI: 10.15227/orgsyn.088.0427  1
2011 Yu YY, Niphakis MJ, Georg GI. Palladium(II)-catalyzed dehydrogenative alkenylation of cyclic enaminones via the Fujiwara-Moritani reaction. Organic Letters. 13: 5932-5. PMID 21995751 DOI: 10.1021/ol202677g  1
2011 Bi L, Georg GI. Direct Hiyama cross-coupling of enaminones with triethoxy(aryl)silanes and dimethylphenylsilanol. Organic Letters. 13: 5413-5. PMID 21939201 DOI: 10.1021/ol202202a  1
2011 Leighty MW, Georg GI. Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A. Acs Medicinal Chemistry Letters. 2: 313-315. PMID 21779519 DOI: 10.1021/ml1003074  1
2011 Schneider CM, Khownium K, Li W, Spletstoser JT, Haack T, Georg GI. Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization. Angewandte Chemie (International Ed. in English). 50: 7855-7. PMID 21717556 DOI: 10.1002/anie.201103081  1
2011 Seki H, Georg GI. Three-component synthesis of cyclic enaminones via ketene cyclization. Organic Letters. 13: 2147-9. PMID 21456588 DOI: 10.1021/ol200358h  1
2011 Pepe A, Pamment M, Georg GI, Malhotra SV. Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines. The Journal of Organic Chemistry. 76: 3527-30. PMID 21452823 DOI: 10.1021/jo102558u  1
2011 Betzi S, Alam R, Martin M, Lubbers DJ, Han H, Jakkaraj SR, Georg GI, Schönbrunn E. Discovery of a potential allosteric ligand binding site in CDK2. Acs Chemical Biology. 6: 492-501. PMID 21291269 DOI: 10.1021/cb100410m  1
2011 Niphakis MJ, Georg GI. Synthesis of tylocrebrine and related phenanthroindolizidines by VOF3-mediated oxidative aryl-alkene coupling. Organic Letters. 13: 196-9. PMID 21142214 DOI: 10.1021/ol1023954  1
2011 Doan TL, Pollastri M, Walters MA, Georg GI. The Future of Drug Repositioning. Old Drugs, New Opportunities Annual Reports in Medicinal Chemistry. 46: 385-401. DOI: 10.1016/B978-0-12-386009-5.00004-7  1
2010 Seki H, Georg GI. Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles. Journal of the American Chemical Society. 132: 15512-3. PMID 20958040 DOI: 10.1021/ja107329k  1
2010 Niphakis MJ, Turunen BJ, Georg GI. Synthesis of 6- and 7-membered cyclic enaminones: scope and mechanism. The Journal of Organic Chemistry. 75: 6793-805. PMID 20929269 DOI: 10.1021/jo100907u  1
2010 Niphakis MJ, Georg GI. Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine. The Journal of Organic Chemistry. 75: 6019-22. PMID 20704319 DOI: 10.1021/jo101051w  1
2010 Reiff EA, Nair SK, Henri JT, Greiner JF, Reddy BS, Chakrasali R, David SA, Chiu TL, Amin EA, Himes RH, Vander Velde DG, Georg GI. Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin. The Journal of Organic Chemistry. 75: 86-94. PMID 19954175 DOI: 10.1021/jo901752v  1
2010 Hemenway JN, Jarho P, Henri JT, Nair SK, VanderVelde D, Georg GI, Stella VJ. Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine. Journal of Pharmaceutical Sciences. 99: 1810-25. PMID 19774656 DOI: 10.1002/jps.21952  1
2009 Ward TR, Turunen BJ, Haack T, Neuenswander B, Shadrick W, Georg GI. Synthesis of a quinolone library from ynones. Tetrahedron Letters. 50: 6494-9497. PMID 20161410 DOI: 10.1016/j.tetlet.2009.09.024  1
2009 Chakrabarti S, Svojanovsky SR, Slavik R, Georg GI, Wilson GS, Smith PG. Artificial neural network--based analysis of high-throughput screening data for improved prediction of active compounds. Journal of Biomolecular Screening. 14: 1236-44. PMID 19940083 DOI: 10.1177/1087057109351312  1
2009 Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL. (3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent. Journal of Medicinal Chemistry. 52: 7537-43. PMID 19728715 DOI: 10.1021/jm900254k  1
2009 Talukdar A, Breen M, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Cushman M. Discovery and development of a small molecule library with lumazine synthase inhibitory activity Journal of Organic Chemistry. 74: 5123-5134. PMID 19552377 DOI: 10.1021/jo900238q  1
2009 Zhao Y, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Fanwick PE, Franzblau SG, Wan B, Cushman M. Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis Journal of Organic Chemistry. 74: 5297-5303. PMID 19545132 DOI: 10.1021/jo900768c  1
2009 Hutt OE, Inagaki J, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, VanderVelde DG, Chiu TL, Amin EA, Himes RH, Georg GI. Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin. Bioorganic & Medicinal Chemistry Letters. 19: 3293-6. PMID 19428248 DOI: 10.1016/j.bmcl.2009.04.077  1
2009 Michaelis ML, Georg G, Telikepalli H, McIntosh M, Rajewski RA. Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice (Current Alzheimer Research 3, 3, (215-219)) Current Alzheimer Research. 6: 320. DOI: 10.2174/156720509788486635  1
2008 Ge H, Wang J, Kayser MM, Himes RH, Georg GI. Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel. Bioorganic & Medicinal Chemistry Letters. 18: 6165-7. PMID 18977659 DOI: 10.1016/j.bmcl.2008.10.010  1
2008 Turunen BJ, Ge H, Oyetunji J, Desino KE, Vasandani V, Güthe S, Himes RH, Audus KL, Seelig A, Georg GI. Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & Medicinal Chemistry Letters. 18: 5971-4. PMID 18926701 DOI: 10.1016/j.bmcl.2008.09.103  1
2008 Hutt OE, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, Chiu TL, Vandervelde DG, Amin EA, Himes RH, Georg GI. Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells. Bioorganic & Medicinal Chemistry Letters. 18: 4904-6. PMID 18684624 DOI: 10.1016/j.bmcl.2008.07.024  1
2008 Santhapuram HK, Datta A, Hutt OE, Georg GI. N-methylation of the c3' amide of taxanes: synthesis of N-methyltaxol C and N-methylpaclitaxel. The Journal of Organic Chemistry. 73: 4705-8. PMID 18498195 DOI: 10.1021/jo800173h  1
2008 Scott Kimball F, Himes RH, Georg GI. Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line. Bioorganic & Medicinal Chemistry Letters. 18: 3248-50. PMID 18479919 DOI: 10.1016/j.bmcl.2008.04.051  1
2008 Kimball FS, Turunen BJ, Ellis KC, Himes RH, Georg GI. Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers. Bioorganic & Medicinal Chemistry. 16: 4367-77. PMID 18343127 DOI: 10.1016/j.bmc.2008.02.073  1
2008 Ge H, Niphakis MJ, Georg GI. Palladium(II)-catalyzed direct arylation of enaminones using organotrifluoroborates. Journal of the American Chemical Society. 130: 3708-9. PMID 18321102 DOI: 10.1021/ja710221c  1
2008 Tash JS, Attardi B, Hild SA, Chakrasali R, Jakkaraj SR, Georg GI. A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose. Biology of Reproduction. 78: 1127-38. PMID 18218612 DOI: 10.1095/biolreprod.106.057810  1
2008 Tash JS, Chakrasali R, Jakkaraj SR, Hughes J, Smith SK, Hornbaker K, Heckert LL, Ozturk SB, Hadden MK, Kinzy TG, Blagg BS, Georg GI. Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Biology of Reproduction. 78: 1139-52. PMID 18218611 DOI: 10.1095/biolreprod.107.062679  1
2008 Vedantham P, Guerra JM, Schoenen F, Huang M, Gor PJ, Georg GI, Wang JL, Neuenswander B, Lushington GH, Mitscher LA, Ye QZ, Hanson PR. Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors. Journal of Combinatorial Chemistry. 10: 185-94. PMID 18163595 DOI: 10.1021/cc700085c  1
2008 Vedantham P, Zhang M, Gor PJ, Huang M, Georg GI, Lushington GH, Mitscher LA, Ye QZ, Hanson PR. Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent. Journal of Combinatorial Chemistry. 10: 195-203. PMID 18163594 DOI: 10.1021/cc7000869  1
2007 Wang X, Turunen BJ, Leighty MW, Georg GI. Microwave-assisted Suzuki-Miyaura couplings on α-iodoenaminones. Tetrahedron Letters. 48: 8811-8814. PMID 19079569 DOI: 10.1016/j.tetlet.2007.10.078  1
2007 Kimball FS, Tunoori AR, Victory SF, Dutta D, White JM, Himes RH, Georg GI. Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones. Bioorganic & Medicinal Chemistry Letters. 17: 4703-7. PMID 17614274 DOI: 10.1016/j.bmcl.2007.05.103  1
2007 Fried KW, Schneider CM, Schramm KW, Datta A, Chahbane N, Corsten C, Powell DR, Lenoir D, Kettrup A, Terranova P, Georg GI, Rozman KK. From dioxin to drug lead--the development of 2,3,7,8-tetrachlorophenothiazine. Chemmedchem. 2: 890-7. PMID 17394264 DOI: 10.1002/cmdc.200700005  1
2007 Spletstoser JT, White JM, Tunoori AR, Georg GI. Mild and selective hydrozirconation of amides to aldehydes using Cp2Zr(H)Cl: scope and mechanistic insight. Journal of the American Chemical Society. 129: 3408-19. PMID 17315870 DOI: 10.1021/ja066362+  1
2007 Ge H, Spletstoser JT, Yang Y, Kayser M, Georg GI. Synthesis of docetaxel and butitaxel analogues through kinetic resolution of racemic beta-lactams with 7-O-triethylsilylbaccatin III. The Journal of Organic Chemistry. 72: 756-9. PMID 17253791 DOI: 10.1021/jo061339s  1
2007 Ahn YM, Vogeti L, Liu CJ, Santhapuram HK, White JM, Vasandani V, Mitscher LA, Lushington GH, Hanson PR, Powell DR, Himes RH, Roby KF, Ye Q, Georg GI. Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. Bioorganic & Medicinal Chemistry. 15: 702-13. PMID 17123821 DOI: 10.1016/j.bmc.2006.10.063  1
2007 Dutta D, Datta A, Vander Velde DG, Georg GI. Oxidation of baccatin III at C14: A facile rearrangement of the baccatin III core Letters in Organic Chemistry. 4: 151-154. DOI: 10.2174/157017807780737246  1
2006 Turunen BJ, Georg GI. Amino acid-derived enaminones: a study in ring formation providing valuable asymmetric synthons. Journal of the American Chemical Society. 128: 8702-3. PMID 16819843 DOI: 10.1021/ja0609046  1
2006 Fang J, Dong Y, Lushington GH, Ye QZ, Georg GI. Support vector machines in HTS data mining: Type I MetAPs inhibition study. Journal of Biomolecular Screening. 11: 138-44. PMID 16418315 DOI: 10.1177/1087057105284334  1
2006 Khownium K, Wood SJ, Miller KA, Balakrishna R, Nguyen TB, Kimbrell MR, Georg GI, David SA. Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds. Bioorganic & Medicinal Chemistry Letters. 16: 1305-8. PMID 16377188 DOI: 10.1016/j.bmcl.2005.11.059  1
2006 Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI. Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 495-8. PMID 16289636 DOI: 10.1016/j.bmcl.2005.10.063  1
2006 Ge H, Vasandani V, Huff JK, Audus KL, Himes RH, Seelig A, Georg GI. Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 433-6. PMID 16271474 DOI: 10.1016/j.bmcl.2005.09.043  1
2006 Blackman B, Georg GI, Lushington GH. CoMSIA/QSAR models for vacuolar (H+) ATPase inhibition by selected benzoate and benzolactone species Letters in Drug Design and Discovery. 3: 104-107. DOI: 10.2174/157018006775789748  1
2005 Haack K, Ahn YM, Georg GI. A convenient method to remove ruthenium byproducts from olefin metathesis reactions using polymer-bound triphenylphosphine oxide (TPPO). Molecular Diversity. 9: 301-3. PMID 16311806 DOI: 10.1007/s11030-005-2480-6  1
2005 Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH. Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry. 44: 13457-66. PMID 16216069 DOI: 10.1021/bi051140u  1
2005 Haack T, Haack K, Diederich WE, Blackman B, Roy S, Pusuluri S, Georg GI. Formal total syntheses of the (-)-salicylihalamides A and B from D-glucose and L-rhamnose. The Journal of Organic Chemistry. 70: 7592-604. PMID 16149788 DOI: 10.1021/jo050750x  1
2005 Chen J, Illarionov B, Bacher A, Fischer M, Haase I, Georg G, Ye QZ, Ma Z, Cushman M. A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors Analytical Biochemistry. 338: 124-130. PMID 15707942 DOI: 10.1016/j.ab.2004.11.033  1
2005 Rice A, Liu Y, Michaelis ML, Himes RH, Georg GI, Audus KL. Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ. Journal of Medicinal Chemistry. 48: 832-8. PMID 15689167 DOI: 10.1021/jm040114b  1
2005 Michaelis ML, Ansar S, Chen Y, Reiff ER, Seyb KI, Himes RH, Audus KL, Georg GI. {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents. The Journal of Pharmacology and Experimental Therapeutics. 312: 659-68. PMID 15375176 DOI: 10.1124/jpet.104.074450  1
2004 Spletstoser JT, Flaherty PT, Himes RH, Georg GI. Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe. Journal of Medicinal Chemistry. 47: 6459-65. PMID 15588080 DOI: 10.1021/jm030581d  1
2004 Safavy A, Georg GI, Vander Velde D, Raisch KP, Safavy K, Carpenter M, Wang W, Bonner JA, Khazaeli MB, Buchsbaum DJ. Site-specifically traced drug release and biodistribution of a paclitaxel-antibody conjugate toward improvement of the linker structure. Bioconjugate Chemistry. 15: 1264-74. PMID 15546192 DOI: 10.1021/bc049868v  1
2004 Buck SB, Huff JK, Himes RH, Georg GI. Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24. Journal of Medicinal Chemistry. 47: 3697-9. PMID 15214797 DOI: 10.1021/jm030555f  1
2004 White JM, Tunoori AR, Turunen BJ, Georg GI. [Bis(2-methoxyethyl)amino]sulfur trifluoride, the Deoxo-Fluor reagent: application toward one-flask transformations of carboxylic acids to amides. The Journal of Organic Chemistry. 69: 2573-6. PMID 15049661 DOI: 10.1021/jo035658k  1
2004 Barboni L, Giarlo G, Ricciutelli M, Ballini R, Georg GI, VanderVelde DG, Himes RH, Wang M, Lakdawala A, Snyder JP. Synthesis, modeling, and anti-tubulin activity of a D-seco paclitaxel analogue. Organic Letters. 6: 461-4. PMID 14961598 DOI: 10.1021/ol036204c  1
2004 Buck SB, Huff JK, Himes RH, Georg GI. Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24. Journal of Medicinal Chemistry. 47: 696-702. PMID 14736249 DOI: 10.1021/jm030278c  1
2004 Reiff EA, Nair SK, Narayan Reddy BS, Inagaki J, Henri JT, Greiner JF, Georg GI. Practical syntheses of the C12-C21 epothilone subunit via catalytic asymmetric reductions: Itsuno-Corey oxazaborolidine reduction and asymmetric Noyori hydrogenation Tetrahedron Letters. 45: 5845-5847. DOI: 10.1016/j.tetlet.2004.06.009  1
2004 Tripathy NK, Georg GI. RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A) Tetrahedron Letters. 45: 5309-5311. DOI: 10.1016/j.tetlet.2004.04.164  1
2004 Spletstoser JT, White JM, Georg GI. One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp2Zr(D)Cl Tetrahedron Letters. 45: 2787-2789. DOI: 10.1016/j.tetlet.2004.02.030  1
2003 Haack T, Kurtkaya S, Snyder JP, Georg GI. Studies toward the synthesis of oximidines I and II. Organic Letters. 5: 5019-22. PMID 14682754 DOI: 10.1021/ol036007d  1
2003 Yang K, Blackman B, Diederich W, Flaherty PT, Mossman CJ, Roy S, Ahn YM, Georg GI. Formal total synthesis of (+)-salicylihalamides A and B: a combined chiral pool and RCM strategy. The Journal of Organic Chemistry. 68: 10030-9. PMID 14682697 DOI: 10.1021/jo0301550  1
2003 Vidya R, Eggen M, Nair SK, Georg GI, Himes RH. Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization. The Journal of Organic Chemistry. 68: 9687-93. PMID 14656095 DOI: 10.1021/jo0302197  1
2003 Yang K, Haack T, Blackman B, Diederich WE, Roy S, Pusuluri S, Georg GI. Enantiospecific formal total syntheses of (-)-salicylihalamides A and B from D-glucose and L-rhamnose. Organic Letters. 5: 4007-9. PMID 14535765 DOI: 10.1021/ol035630v  1
2003 Gupta ML, Bode CJ, Georg GI, Himes RH. Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proceedings of the National Academy of Sciences of the United States of America. 100: 6394-7. PMID 12740436 DOI: 10.1073/pnas.1131967100  1
2003 Vidya R, Eggen M, Georg GI, Himes RH. Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24. Bioorganic & Medicinal Chemistry Letters. 13: 757-60. PMID 12639575 DOI: 10.1016/S0960-894X(02)01023-5  1
2003 Blackman B, Georg GI. Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions Chemtracts. 16: 97-104.  1
2002 Ahn YM, Vander Velde DG, Georg GI. Synthetic studies with 13-deoxybaccatin III. The Journal of Organic Chemistry. 67: 7140-3. PMID 12354012 DOI: 10.1021/jo011183q  1
2002 Bode CJ, Gupta ML, Reiff EA, Suprenant KA, Georg GI, Himes RH. Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry. 41: 3870-4. PMID 11900528 DOI: 10.1021/bi0121611  1
2002 Liu Y, Ali SM, Boge TC, Georg GI, Victory S, Zygmunt J, Marquez RT, Himes RH. A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach. Combinatorial Chemistry & High Throughput Screening. 5: 39-48. PMID 11860338  1
2002 Eggen M, Georg GI. The cryptophycins: their synthesis and anticancer activity. Medicinal Research Reviews. 22: 85-101. PMID 11857635 DOI: 10.1002/med.10002  1
2001 Krishna Reddy SH, Lee S, Datta A, Georg GI. Efficient synthesis of the 3'-phenolic metabolite of paclitaxel. The Journal of Organic Chemistry. 66: 8211-4. PMID 11722227 DOI: 10.1021/jo0102516  1
2001 Eggen M, Nair SK, Georg GI. Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24. Organic Letters. 3: 1813-5. PMID 11405718 DOI: 10.1021/ol010044s  1
2001 Ahn YM, Yang K, Georg GI. A convenient method for the efficient removal of ruthenium byproducts generated during olefin metathesis reactions. Organic Letters. 3: 1411-3. PMID 11348247 DOI: 10.1021/ol010045k  1
2001 Barboni L, Datta A, Dutta D, Georg GI, Vander Velde DG, Himes RH, Wang M, Snyder JP. Novel d-seco paclitaxel analogues: synthesis, biological evaluation, and model testing. The Journal of Organic Chemistry. 66: 3321-9. PMID 11348113 DOI: 10.1021/jo0015467  1
2001 Georg GI, Yu Mi Ahn, Blackman B, Farokhi F, Flaherty PT, Mossman CJ, Roy S, Yang K. Short and efficient chiral pool and RCM approach towards the synthesis of the macrocyclic core of the salicylihalamides Chemical Communications. 255-256.  1
2000 Tunoori AR, White JM, Georg GI. A one-flask synthesis of Weinreb amides from chiral and achiral carboxylic acids using the deoxo-fluor fluorinating reagent. Organic Letters. 2: 4091-3. PMID 11112651  1
2000 Eggen M, Mossman CJ, Buck SB, Nair SK, Bhat L, Ali SM, Reiff EA, Boge TC, Georg GI. Total synthesis of cryptophycin-24 (Arenastatin A) amenable to structural modifications in the C16 side chain. The Journal of Organic Chemistry. 65: 7792-9. PMID 11073583 DOI: 10.1021/jo000767+  1
2000 White JM, Tunoori AR, Dutta D, Georg GI. The use of polymer-bound triphenylphosphine in the stereochemical inversion of secondary alcohols. Combinatorial Chemistry & High Throughput Screening. 3: 103-6. PMID 10788580  1
2000 White JM, Tunoori AR, Georg GI. A novel and expeditious reduction of tertiary amides to aldehydes using Cp2Zr(H)Cl [1] Journal of the American Chemical Society. 122: 11995-11996. DOI: 10.1021/ja002149g  1
2000 White JM, Tunoori AR, Georg GI. Selective reduction with Cp 2ZrHCl Chemical Innovation. 30: 23-30.  1
2000 Nair SK, Smith AB, Henri JT, Kaufman MD, Georg GI, Beauchamp TJ, LaMarche MJ, Arimoto H. An efficient gram-scale synthesis of (+)-discodermolide Chemtracts. 13: 229-236.  1
2000 Flaherty PT, Takahashi S, Georg GI, Kuzuyama T, Watanabe H, Seto H. The non-mevalonate pathway for isoprenoid biosynthesis: New opportunities for drug design Chemtracts. 13: 237-244.  1
1999 Dutta D, Hadd H, Vander Velde DG, Georg GI. A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel. Bioorganic & Medicinal Chemistry Letters. 9: 3277-8. PMID 10612584  1
1999 Boge TC, Wu ZJ, Himes RH, Vander Velde DG, Georg GI. Conformationally restricted paclitaxel analogues: macrocyclic mimics of the "hydrophobic collapse" conformation. Bioorganic & Medicinal Chemistry Letters. 9: 3047-52. PMID 10571173 DOI: 10.1016/S0960-894X(99)00522-3  1
1999 Boge TC, Hepperle M, Vander Velde DG, Gunn CW, Grunewald GL, Georg GI. The oxetane conformational lock of paclitaxel: structural analysis of D-secopaclitaxel. Bioorganic & Medicinal Chemistry Letters. 9: 3041-6. PMID 10571172 DOI: 10.1016/S0960-894X(99)00521-1  1
1999 Krise JP, Zygmunt J, Georg GI, Stella VJ. Novel prodrug approach for tertiary amines: synthesis and preliminary evaluation of N-phosphonooxymethyl prodrugs. Journal of Medicinal Chemistry. 42: 3094-100. PMID 10447953 DOI: 10.1021/jm980539w  1
1998 Bhat L, Liu Y, Victory SF, Himes RH, Georg GI. Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries. Bioorganic & Medicinal Chemistry Letters. 8: 3181-6. PMID 9873699  1
1998 Eggen MJ, Georg GI. Enantioselective synthesis of a 3'-dephenylcryptophycin synthon. Bioorganic & Medicinal Chemistry Letters. 8: 3177-80. PMID 9873698  1
1998 Georg GI, Ali SM, Stella VJ, Waugh WN, Himes RH. Halohydrin analogues of cryptophycin 1: synthesis and biological activity. Bioorganic & Medicinal Chemistry Letters. 8: 1959-62. PMID 9873466 DOI: 10.1016/S0960-894X(98)00356-4  1
1998 Georg GI, Harriman GCB, Datta A, Ali S, Cheruvallath Z, Dutta D, Vander Velde DG, Himes RH. The chemistry of the taxane diterpene: Stereoselective reductions of taxanes Journal of Organic Chemistry. 63: 8926-8934. DOI: 10.1021/jo981194s  1
1998 Tunoori AR, Dutta D, Georg GI. Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols nad alcohols Tetrahedron Letters. 39: 8751-8754.  1
1998 Buck SB, Victory SF, Himes RH, Georg GI. Epothilones, a new class of microtubule-stabilizing agents with a taxol- like mechanism of action Chemtracts. 11: 671-677.  1
1997 Sengupta S, Boge TC, Liu Y, Hepperle M, Georg GI, Himes RH. Probing the environment of tubulin-bound paclitaxel using fluorescent paclitaxel analogues. Biochemistry. 36: 5179-84. PMID 9136879 DOI: 10.1021/bi962891m  1
1997 Ali SM, Hoemann MZ, Aubé J, Georg GI, Mitscher LA, Jayasinghe LR. Butitaxel analogues: synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 40: 236-41. PMID 9003522 DOI: 10.1021/jm960505t  1
1997 Georg GI, Liu Y, Boge TC, Himes RH. 7-O-acylpaclitaxel analogues: Potential probes to map the paclitaxel binding site Bioorganic and Medicinal Chemistry Letters. 7: 1829-1832. DOI: 10.1016/S0960-894X(97)00329-6  1
1997 Ali SM, Georg GI. Formal syntheses of cryptophycin A and arenastatin A Tetrahedron Letters. 38: 1703-1706. DOI: 10.1016/S0040-4039(97)00194-9  1
1996 Georg GI, Harriman GC, Hepperle M, Clowers JS, Vander Velde DG, Himes RH. Synthesis, Conformational Analysis, and Biological Evaluation of Heteroaromatic Taxanes. The Journal of Organic Chemistry. 61: 2664-2676. PMID 11667096 DOI: 10.1021/jo951961c  1
1996 Park H, Hepperle M, Boge TC, Himes RH, Georg GI. Preparation of phenolic paclitaxel metabolites. Journal of Medicinal Chemistry. 39: 2705-9. PMID 8709100 DOI: 10.1021/jm960142x  1
1996 Wu Z, Georg GI, Cathers BE, Schloss JV. Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor Bioorganic and Medicinal Chemistry Letters. 6: 983-986. DOI: 10.1016/0960-894X(96)00153-9  1
1996 Victory SF, Vander Velde DG, Jalluri RK, Grunewald GL, Georg GI. Relative stereochemistry and solution conformation of the novel paclitaxel-like antimitotic agent epothilone A Bioorganic and Medicinal Chemistry Letters. 6: 893-898. DOI: 10.1016/0960-894X(96)00139-4  1
1995 Kerksiek K, Mejillano MR, Schwartz RE, Georg GI, Himes RH. Interaction of cryptophycin 1 with tubulin and microtubules. Febs Letters. 377: 59-61. PMID 8543019 DOI: 10.1016/0014-5793(95)01271-0  1
1995 Ali SM, Hoemann MZ, Aubé J, Mitscher LA, Georg GI, McCall R, Jayasinghe LR. Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel. Journal of Medicinal Chemistry. 38: 3821-8. PMID 7562913  1
1995 Georg GI, Boge TC, Park H, Himes RH. Paclitaxel and docetaxel photoaffinity labels Bioorganic and Medicinal Chemistry Letters. 5: 615-620. DOI: 10.1016/0960-894X(95)00083-6  1
1995 Georg GI, Ali SM, Boge TC, Datta A, Falborg L, Park H, Mejillano M, Himes RH. Synthesis of biologically active 2-benzoyl paclitaxel analogues Bioorganic and Medicinal Chemistry Letters. 5: 259-264. DOI: 10.1016/0960-894X(95)00020-T  1
1995 Georg GI, Harriman GCB, Ali SM, Datta A, Hepperle M, Himes RH. Synthesis of 2-O-heteroaroyl taxanes: evaluation of microtubule assembly promotion and cytotoxicity Bioorganic and Medicinal Chemistry Letters. 5: 115-118. DOI: 10.1016/0960-894X(94)00468-U  1
1995 Harriman GCB, Jalluri RK, Granewald GL, Vander Velde DG, Georg GI, Himes RH. The chemistry of the taxane diterpene: Stereoselective synthesis of 10-deacetoxy-11,12-epoxypaclitaxel Tetrahedron Letters. 36: 8909-8912. DOI: 10.1016/0040-4039(95)01928-B  1
1995 Datta A, Vander Velde DG, Georg GI, Himes RH. Syntheses of novel C-9 and C-10 modified bioactive taxanes Tetrahedron Letters. 36: 1985-1988. DOI: 10.1016/0040-4039(95)00208-T  1
1995 Georg GI, Cheruvallath ZS, Vander Velde DG, Himes RH. Stereoselective synthesis of 9β-hydroxytaxanes via reduction with samarium diiodide Tetrahedron Letters. 36: 1783-1786. DOI: 10.1016/0040-4039(95)00142-Y  1
1995 Datta A, Hepperle M, Georg GI. Selective deesterification studies on taxanes: Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities Journal of Organic Chemistry. 60: 761-763.  1
1995 Hoemann MZ, Velde DV, Aubé J, Georg GI, Jayasinghe LR. Synthesis of 13-epi-taxol via a transannular delivery of a borohydride reagent Journal of Organic Chemistry. 60: 2918-2921.  1
1995 Georg GI, Harriman GCB, Peterson SA. A facile one-flask conversion of aldehydes and ketones to N-sulfonyl imines The Journal of Organic Chemistry. 60: 7366-7368.  1
1994 Datta A, Jayasinghe LR, Georg GI. 4-deacetyltaxol and 10-acetyl-4-deacetyltaxotere: Synthesis and biological evaluation Journal of Medicinal Chemistry®. 37: 4258-4260. PMID 7990125  1
1994 Boge TC, Himes RH, Vander Velde DG, Georg GI. The effect of the aromatic rings of taxol on biological activity and solution conformation: synthesis and evaluation of saturated taxol and taxotere analogues. Journal of Medicinal Chemistry. 37: 3337-43. PMID 7932561  1
1994 Vander Velde DG, Georg GI, Gollapudi SR, Jampani HB, Liang XZ, Mitscher LA, Ye QM. Wallifoliol, a taxol congener with a novel carbon skeleton, from Himalayan Taxus wallichiana. Journal of Natural Products. 57: 862-7. PMID 7931372  1
1994 Jayasinghe LR, Datta A, Ali SM, Zygmunt J, Vander Velde DG, Georg GI. Structure-activity studies of antitumor taxanes: Synthesis of novel C-13 side chain homologated taxol and taxotere analogs Journal of Medicinal Chemistry. 37: 2981-2984. PMID 7915328  1
1994 Dasgupta D, Park H, Harriman GC, Georg GI, Himes RH. Synthesis of a photoaffinity taxol analogue and its use in labeling tubulin. Journal of Medicinal Chemistry. 37: 2976-80. PMID 7915327  1
1994 Georg GI, Ali SM, Zygmunt J, Jayasinghe LR. Overview oncologic, metabolic & endocrine: Taxol: A novel antitumour agent Expert Opinion On Therapeutic Patents. 4: 109-120. DOI: 10.1517/13543776.4.2.109  1
1994 Datta A, Aubé J, Georg GI, Mitscher LA, Jayasinghe LR. The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol® and taxotere® analogues Bioorganic and Medicinal Chemistry Letters. 4: 1831-1834. DOI: 10.1016/S0960-894X(01)80379-6  1
1994 Georg GI, Boge TC, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues Bioorganic and Medicinal Chemistry Letters. 4: 1825-1830. DOI: 10.1016/S0960-894X(01)80378-4  1
1994 Georg GI, Harriman GCB, Hepperle M, Himes RH. Heteroaromatic Taxol Analogues: The Chemistry and Biological Activities of 3′-Furyl and 3′-Pyridyl Substituted Taxanes Bioorganic and Medicinal Chemistry Letters. 4: 1381-1384. DOI: 10.1016/S0960-894X(01)80366-8  1
1994 Georg GI, Boge TC, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation Bioorganic and Medicinal Chemistry Letters. 4: 335-338. DOI: 10.1016/S0960-894X(01)80139-6  1
1994 Georg GI, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Synthesis and biology of substituted 3′-phenyl taxol analogues Bioorganic and Medicinal Chemistry Letters. 4: 2331-2336. DOI: 10.1016/0960-894X(94)85035-6  1
1994 Georg GI, Harriman GCB, Park H, Himes RH. Taxol photoaffinity labels 2. Synthesis and biological evaluation of N-(4-azidobenzoyl)-N-debenzoyltaxol, N-(4-azido-2,3,5,6-tetrafluorobenzoyl)-N-debenzoyltaxol, and 7-(4-azido-2,3,5,6-tetrafluorobenzoyl)taxol Bioorganic and Medicinal Chemistry Letters. 4: 487-490. DOI: 10.1016/0960-894X(94)80022-7  1
1994 Georg GI, Ali SM, Boge TC, Datta A, Falborg L, Himes RH. Selective C-2 and C-4 deacylation and acylation of taxol: The first synthesis of a C-4 substituted taxol analogue Tetrahedron Letters. 35: 8931-8934. DOI: 10.1016/0040-4039(94)88392-0  1
1994 Georg GI, Wu Z. An investigation of (R)-(+)-1-(1-naphthyl)ethylimines and (R)-(+)-1-(phenyl)ethylimines as chiral templates in the staudinger reaction Tetrahedron Letters. 35: 381-384. DOI: 10.1016/0040-4039(94)85059-3  1
1994 Datta A, Jayasinghe LR, Georg GI. Internal nucleophile assisted selective deesterification studies on baccatin III. Synthesis of 2-debenzoyl- and 4-deacetylbaccatin III analogues Journal of Organic Chemistry. 59: 4689-4690.  1
1994 Georg GI, Cheruvallath ZS. Samarium diiodide-mediated deoxygenation of taxol: A one-step synthesis of 10-deacetoxytaxol Journal of Organic Chemistry. 59: 4015-4018.  1
1994 Hepperle M, Georg GI. Taxol analogs Drugs of the Future. 19: 573-584.  1
1993 Vander Velde DG, Georg GI, Grunewald GL, Gunn CW, Mitscher LA. 'Hydrophobic collapse' of taxol and taxotere solution conformation in mixtures of water and organic solvent Journal of the American Chemical Society. 115: 11650-11651. DOI: 10.1021/ja00077a095  1
1993 Georg GI, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H. An efficient semisynthesis of taxol from (3R,4S)-N-Benzoyl-3-[(t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III Bioorganic and Medicinal Chemistry Letters. 3: 2467-2470. DOI: 10.1016/S0960-894X(01)80979-3  1
1993 Georg GI. Introduction: Recent advances in the chemistry and biology of β-lactams and β-lactam antibiotics Bioorganic and Medicinal Chemistry Letters. 3: 2157. DOI: 10.1016/S0960-894X(01)80917-3  1
1993 Georg GI, Cheruvallath ZS, Velde DV, Ye QM, Mitscher LA, Himes RH. Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate] Bioorganic and Medicinal Chemistry Letters. 3: 1349-1350. DOI: 10.1016/S0960-894X(00)80346-7  1
1993 Georg GI, Gollapudi SR, Grunewald GL, Gunn CW, Himes RH, Rao BK, Liang XZ, Mirhom YW, Mitscher LA, Vander Velde aG, Ye QM. A reinvestigation of the taxol content of himalayan taxus wallichiana zucc. and a revision of the structure of brevifoliol. Bioorganic and Medicinal Chemistry Letters. 3: 1345-1348. DOI: 10.1016/S0960-894X(00)80345-5  1
1993 Georg GI, He P, Kant J, Wu ZJ. Stereocontrolled synthesis of N-vinyl-, N-(1′-propenyl)-, and N-unsubstituted-β-lactams from 2-aza-1,3-butadienes via the Staudinger reaction Journal of Organic Chemistry. 58: 5771-5778.  1
1992 Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR, Burke CT. Synthesis of biologically active taxol analogues with modified phenylisoserine side chains. Journal of Medicinal Chemistry. 35: 4230-7. PMID 1359143  1
1992 Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR. Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate ) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate ) Bioorganic and Medicinal Chemistry Letters. 2: 295-298. DOI: 10.1016/S0960-894X(01)80203-1  1
1992 Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR. Baccatin III 13-(N-benzoyl-(2'R,3'S)-3'-(p-tolyl)isoserinate), baccatin III 13-(N-(p-toluoyl)-(2'R,3'S)-3'-phenylisoserinate), baccatin III 13-(N-benzoyl-(2'R,3'S)-3'-(p-trifluoromethylphenyl)isoserinate), and baccatin III 13-(N-(p-trifluoromethylbenzoyl)-(2'R,3'S)-3'-phenylisoserinate) Bioorganic and Medicinal Chemistry Letters. 2: 1751-1754. DOI: 10.1016/S0960-894X(00)80469-2  1
1992 Georg GI, Akgün E, Mashava PM, Milstead M, Ping H, Wu Zj, Velde DV, Takusagawa F. Galactose-Imines in the staudinger reaction Tetrahedron Letters. 33: 2111-2114. DOI: 10.1016/0040-4039(92)88153-V  1
1991 Georg GI, Guan X, Kant J. Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids Bioorganic and Medicinal Chemistry Letters. 1: 125-128. DOI: 10.1016/S0960-894X(00)80245-0  1
1991 Georg GI, Mashava PM, Akgün E, Milstead MW. Asymmetric synthesis of β-lactams and n-benzoyl-3-phenylisoserines via the staudinger reaction Tetrahedron Letters. 32: 3151-3154. DOI: 10.1016/S0040-4039(00)79708-5  1
1991 Georg GI, Mashava PM, Guan X. An improved method for the stereoselective synthesis of β-lactams from carboxylic acids and imines Tetrahedron Letters. 32: 581-584. DOI: 10.1016/S0040-4039(00)74832-5  1
1991 Ojima I, Habus I, Zhao M, Georg GI, Jayasinghe LR. Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogues via chiral 3-hydroxy-4-aryl-β-lactams through chiral ester enolate-imine cyclocondensation Journal of Organic Chemistry. 56: 1681-1683.  1
1990 Georg GI, Akgün E. Metal directed stereoselective synthesis of 3-(1′-hydroxyethyl)-2-azetidinones from ethyl 3-hydroxybutyrate Tetrahedron Letters. 31: 3267-3270. DOI: 10.1016/S0040-4039(00)89040-1  1
1990 Georg GI, He P, Kant J, Mudd J. N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes Tetrahedron Letters. 31: 451-454. DOI: 10.1016/0040-4039(90)87005-K  1
1990 Spencer TK, Georg GI, Aube J. A convenient preparation of 2-[15N]-amino-4,6-dimethoxypyrimidine Journal of Labelled Compounds and Radiopharmaceuticals. 28: 433-436. DOI: 10.1002/jlcr.2580280410  1
1988 Georg GI, Kant J, He P, Ly AM, Lampe L. 2-aza-1,3-dienes as novel precursors for the synthesis of N-unsubstituted β-lactams. A three step synthesis of 4-acetoxy-3-phenoxy-2-azeridinone Tetrahedron Letters. 29: 2409-2412. DOI: 10.1016/S0040-4039(00)87894-6  1
1988 Georg GI, Guan X, Kant J. Asymmetric synthesis of α-alkylated α-amino acids via Schmidt rearrangement of α, α-bisalkylated β-keto esters Tetrahedron Letters. 29: 403-406. DOI: 10.1016/S0040-4039(00)80107-0  1
1988 Georg GI, Kant J. An asymmetric synthesis of carbapenem antibiotic (+)-PS-5 from ethyl 3-hydroxybutanoate Journal of Organic Chemistry. 53: 692-695.  1
1987 Georg GI, Kant J, Gill HS. Asymmetric synthesis of (1′R,3R,4R)-4-acetoxy-3-(1′-((tert-butyldimethylsilyl)oxy)ethyl)-2- azetidinone and other 3-(1′-Hydroxyethyl)-2-azetidinones from (S)-(+)-Ethyl 3-hydroxybutanoate: Formal total synthesis of (+)-thienamycin Journal of the American Chemical Society. 109: 1129-1135.  1
1985 Georg GI, Gill HS, Gerhardt C. 3-(1′-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and n-arylaldimines Tetrahedron Letters. 26: 3903-3906. DOI: 10.1016/S0040-4039(00)98683-0  1
1985 Georg GI, Pfeifer SA, Haake M. A one-step transformation of aromatic aldehydes to nitriles, using S,S-Dimethylsulfurdiimide as iminating agent. Isolation of dithiatetrazocines as reaction intermediates Tetrahedron Letters. 26: 2739-2742. DOI: 10.1016/S0040-4039(00)94899-8  1
1985 Georg GI, Gill HS. Stereo- and enantio-controlled synthesis of chiral intermediates for the total synthesis of thienamycin and related β-lactam antibiotics from 3-hydroxybutyrates Journal of the Chemical Society, Chemical Communications. 1433-1435.  1
1984 Boger DL, Brotherton CE, Georg GI. Thermal, three-carbon + two-atom cycloaddition of cyclopropenone ketals with carbon-heteroatom double bonds: Butenolide, furan, and γ-keto ester preparation Tetrahedron Letters. 25: 5615-5618. DOI: 10.1016/S0040-4039(01)91394-2  1
1984 Georg GI. Stereoselective synthesis of 3-(1-Hydroxyethyl)-2-azetidinonesfrom 3-hydroxybutyrates Tetrahedron Letters. 25: 3779-3782. DOI: 10.1016/S0040-4039(01)91165-7  1
1984 Georg GI, Haake M. Novel methods for the synthesis of N-trichloroacetyl- and N-formyl-S,S-diarylsulfilimines Tetrahedron Letters. 25: 47-48. DOI: 10.1016/S0040-4039(01)91144-X  1
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