cached image

Carston R. Wagner - Publications

Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
development of approaches that will deliver anticancers drug, proteins and nucleic acids to cancer tissues and not normal tissues

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kilic O, Matos de Souza MR, Almotlak A, Wang Y, Siegfried J, Distefano MD, Wagner CR. Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T-cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression. Journal of Medicinal Chemistry. PMID 32852209 DOI: 10.1021/acs.jmedchem.0c00489  0.44
2020 Matos de Souza MR, Cunha MS, Okon A, Monteiro FL, Campanati L, Wagner CR, Costa LJ. and Characterization of the Anti-Zika Virus Activity of ProTides of 2'-C-β-methylguanosine. Acs Infectious Diseases. PMID 32525653 DOI: 10.1021/acsinfecdis.0c00091  0.32
2020 Strom A, Tong CL, Wagner CR. Histidine triad nucleotide-binding proteins HINT1 and HINT2 Share Similar Substrate Specificities and Little Affinity for the Signaling Dinucleotide Ap4A. Febs Letters. PMID 31990367 DOI: 10.1002/1873-3468.13745  0.32
2020 Ahmad Z, Jacobson BA, McDonald MW, Vattendahl Vidal N, Vattendahl Vidal G, Chen S, Dillenburg M, Okon AM, Patel MR, Wagner CR, Kratzke RA. Repression of oncogenic cap-mediated translation by 4Ei-10 diminishes proliferation, enhances chemosensitivity and alters expression of malignancy-related proteins in mesothelioma. Cancer Chemotherapy and Pharmacology. PMID 31974652 DOI: 10.1007/s00280-020-04029-9  0.44
2019 Shah R, Peterson C, Strom A, Dillenburg M, Finzel BC, Kitto KF, Fairbanks CA, Wilcox GL, Wagner CR. Inhibition of Hint1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice. Acs Chemical Neuroscience. PMID 31503445 DOI: 10.1021/acschemneuro.9b00432  0.64
2018 Csizmar CM, Petersburg J, Perry TJ, Rozumalski L, Hackel BJ, Wagner CR. Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density. Journal of the American Chemical Society. PMID 30507196 DOI: 10.1021/jacs.8b09198  0.64
2018 Petersburg J, Shen J, Csizmar CM, Murphy KA, Spanier J, Gabrielse K, Griffith TS, Fife B, Wagner CR. Eradication of Established Tumors by Chemically Self-Assembled Nanoring (CSAN) Targeted T-cells. Acs Nano. PMID 29792808 DOI: 10.1021/acsnano.8b01308  0.64
2018 Csizmar CM, Petersburg J, Hendricks A, Stern LA, Hackel BJ, Wagner CR. Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors. Bioconjugate Chemistry. PMID 29537253 DOI: 10.1021/acs.bioconjchem.8b00058  0.64
2017 Shah R, Zhou A, Wagner CR. Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain. Organic & Biomolecular Chemistry. 15: 10230-10237. PMID 29177353 DOI: 10.1039/c7ob02472j  0.64
2017 Maize KM, Shah R, Strom A, Kumarapperuma SC, Zhou AL, Wagner CR, Finzel BC. A Crystal Structure-Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Molecular Pharmaceutics. PMID 28968488 DOI: 10.1021/acs.molpharmaceut.7b00664  0.76
2017 Okon A, Matos de Souza MR, Shah R, Amorim R, da Costa LJ, Wagner CR. Anchimerically Activatable Antiviral ProTides. Acs Medicinal Chemistry Letters. 8: 958-962. PMID 28947944 DOI: 10.1021/acsmedchemlett.7b00277  0.64
2017 Shah R, Chou TF, Maize KM, Strom A, Finzel BC, Wagner CR. Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain. Biochemical and Biophysical Research Communications. PMID 28739258 DOI: 10.1016/j.bbrc.2017.07.111  0.84
2017 Shah R, Maize KM, Zhou X, Finzel BC, Wagner CR. Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Biochemistry. PMID 28691797 DOI: 10.1021/acs.biochem.7b00148  0.64
2016 Shah R, Strom A, Zhou A, Maize KM, Finzel BC, Wagner CR. Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. Acs Medicinal Chemistry Letters. 7: 780-4. PMID 27563403 DOI: 10.1021/acsmedchemlett.6b00169  1
2016 Shah R, Petersburg J, Gangar AC, Fegan A, Wagner CR, Kumarapperuma SC. In vivo Evaluation of Site-specifically PEGylated Chemically Self-assembled Protein Nanostructures. Molecular Pharmaceutics. PMID 26985775 DOI: 10.1021/acs.molpharmaceut.6b00110  1
2015 Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB. Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E. Scientific Reports. 5: 18233. PMID 26678431 DOI: 10.1038/srep18233  1
2015 Shen J, Vallera DA, Wagner CR. Prosthetic Antigen Receptors. Journal of the American Chemical Society. PMID 26230248 DOI: 10.1021/jacs.5b06166  1
2015 Garzón J, Herrero-Labrador R, Rodríguez-Muñoz M, Shah R, Vicente-Sánchez A, Wagner CR, Sánchez-Blázquez P. HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia. Neuropharmacology. 89: 412-23. PMID 25445489 DOI: 10.1016/j.neuropharm.2014.10.022  1
2014 Chen EZ, Jacobson BA, Patel MR, Okon AM, Li S, Xiong K, Vaidya AJ, Bitterman PB, Wagner CR, Kratzke RA. Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells. Investigational New Drugs. 32: 598-603. PMID 24711125 DOI: 10.1007/s10637-014-0076-7  1
2014 Gabrielse K, Gangar A, Kumar N, Lee JC, Fegan A, Shen JJ, Li Q, Vallera D, Wagner CR. Reversible re-programing of cell-cell interactions. Angewandte Chemie (International Ed. in English). 53: 5112-6. PMID 24700601 DOI: 10.1002/anie.201310645  1
2014 Cao J, He L, Lin G, Hu C, Dong R, Zhang J, Zhu H, Hu Y, Wagner CR, He Q, Yang B. Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α. Biochemical Pharmacology. 89: 20-30. PMID 24345331 DOI: 10.1016/j.bcp.2013.12.002  1
2013 Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. Journal of the American Chemical Society. 135: 16388-96. PMID 24134212 DOI: 10.1021/ja403813b  1
2013 Gangar A, Fegan A, Kumarapperuma SC, Huynh P, Benyumov A, Wagner CR. Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures. Molecular Pharmaceutics. 10: 3514-8. PMID 23829765 DOI: 10.1021/mp400164f  1
2013 Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. The Febs Journal. 280: 3389-98. PMID 23659632 DOI: 10.1111/febs.12330  1
2013 Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR, Sonenberg N, Piccirillo CA. Distinct translational control in CD4+ T cell subsets. Plos Genetics. 9: e1003494. PMID 23658533 DOI: 10.1371/journal.pgen.1003494  1
2013 Zhou X, Chou TF, Aubol BE, Park CJ, Wolfenden R, Adams J, Wagner CR. Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry. 52: 3588-600. PMID 23614568 DOI: 10.1021/bi301616c  1
2013 Rashidian M, Mahmoodi MM, Shah R, Dozier JK, Wagner CR, Distefano MD. A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation. Bioconjugate Chemistry. 24: 333-42. PMID 23425124 DOI: 10.1021/bc3004167  1
2013 Li S, Jia Y, Jacobson B, McCauley J, Kratzke R, Bitterman PB, Wagner CR. Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation. Molecular Pharmaceutics. 10: 523-31. PMID 23289910 DOI: 10.1021/mp300699d  1
2012 Fegan A, Kumarapperuma SC, Wagner CR. Chemically self-assembled antibody nanostructures as potential drug carriers. Molecular Pharmaceutics. 9: 3218-27. PMID 23013206 DOI: 10.1021/mp300303k  1
2012 White BR, Carlson JC, Kerns JL, Wagner CR. Protein interface remodeling in a chemically induced protein dimer. Journal of Molecular Recognition : Jmr. 25: 393-403. PMID 22733548 DOI: 10.1002/jmr.2196  1
2012 Shah NB, Vercellotti GM, White JG, Fegan A, Wagner CR, Bischof JC. Blood-nanoparticle interactions and in vivo biodistribution: impact of surface PEG and ligand properties. Molecular Pharmaceutics. 9: 2146-55. PMID 22668197 DOI: 10.1021/mp200626j  1
2012 Jia Y, Polunovsky V, Bitterman PB, Wagner CR. Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target. Medicinal Research Reviews. 32: 786-814. PMID 22495651 DOI: 10.1002/med.21260  1
2012 Gangar A, Fegan A, Kumarapperuma SC, Wagner CR. Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers. Journal of the American Chemical Society. 134: 2895-7. PMID 22296405 DOI: 10.1021/ja210894g  1
2012 Bardaweel SK, Ghosh B, Wagner CR. Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins. Bioorganic & Medicinal Chemistry Letters. 22: 558-60. PMID 22104145 DOI: 10.1016/j.bmcl.2011.10.082  1
2011 Bardaweel S, Ghosh B, Chou TF, Sadowsky MJ, Wagner CR. E. coli histidine triad nucleotide binding protein 1 (ecHinT) is a catalytic regulator of D-alanine dehydrogenase (DadA) activity in vivo. Plos One. 6: e20897. PMID 21754980 DOI: 10.1371/journal.pone.0020897  1
2011 White BR, Li Q, Wagner CR. Chemically induced self-assembly of enzyme nanorings. Methods in Molecular Biology (Clifton, N.J.). 743: 17-26. PMID 21553179 DOI: 10.1007/978-1-61779-132-1_2  1
2011 Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191 Antimicrobial Agents and Chemotherapy. 55: 2166-2173. PMID 21383096 DOI: 10.1128/AAC.01603-10  1
2010 Li Q, So CR, Fegan A, Cody V, Sarikaya M, Vallera DA, Wagner CR. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic. Journal of the American Chemical Society. 132: 17247-57. PMID 21077608 DOI: 10.1021/ja107153a  1
2010 Bardaweel S, Pace J, Chou TF, Cody V, Wagner CR. Probing the impact of the echinT C-terminal domain on structure and catalysis. Journal of Molecular Biology. 404: 627-38. PMID 20934431 DOI: 10.1016/j.jmb.2010.09.066  1
2010 Fegan A, White B, Carlson JC, Wagner CR. Chemically controlled protein assembly: techniques and applications. Chemical Reviews. 110: 3315-36. PMID 20353181 DOI: 10.1021/cr8002888  1
2010 Jia Y, Chiu TL, Amin EA, Polunovsky V, Bitterman PB, Wagner CR. Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. European Journal of Medicinal Chemistry. 45: 1304-13. PMID 20060622 DOI: 10.1016/j.ejmech.2009.11.054  1
2010 Fegan A, Kumarapperuma SC, Wagner CR. DHFR Fusion proteins for the cellular delivery of methotrexate labeled oligonucleotides 7th Annual Conference On Foundations of Nanoscience: Self-Assembled Architectures and Devices, Fnano 2010. 27-28.  1
2009 White BR, Wagner CR, Truhlar DG, Amin EA. Molecular Modeling of Geometries, Charge Distributions, and Binding Energies of Small, Druglike Molecules Containing Nitrogen Heterocycles and Exocyclic Amino Groups in the Gas Phase and Aqueous Solution. Journal of Chemical Theory and Computation. 5: 1195. PMID 26609629 DOI: 10.1021/ct9000944  0.36
2009 Zhou X, Zhang N, Liu L, Walters KJ, Hanna PE, Wagner CR. Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190. The Febs Journal. 276: 6928-41. PMID 19860825 DOI: 10.1111/j.1742-4658.2009.07389.x  1
2009 Liu L, Wagner CR, Hanna PE. Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines. Chemical Research in Toxicology. 22: 1962-74. PMID 19842618 DOI: 10.1021/tx9002676  1
2009 Cheng J, Zhou X, Chou TF, Ghosh B, Liu B, Wagner CR. Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection. Bioorganic & Medicinal Chemistry Letters. 19: 6379-81. PMID 19825512 DOI: 10.1016/j.bmcl.2009.09.067  1
2009 Zhang H, Zeng X, Li Q, Gaillard-Kelly M, Wagner CR, Yee D. Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore. British Journal of Cancer. 101: 71-9. PMID 19491901 DOI: 10.1038/sj.bjc.6605103  1
2009 Ghosh B, Benyumov AO, Ghosh P, Jia Y, Avdulov S, Dahlberg PS, Peterson M, Smith K, Polunovsky VA, Bitterman PB, Wagner CR. Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. Acs Chemical Biology. 4: 367-77. PMID 19351181 DOI: 10.1021/cb9000475  1
2008 White BR, Wagner CR, Truhlar DG, Amin EA. Molecular Modeling of Geometries, Charge Distributions, and Binding Energies of Small, Drug-Like Molecules Containing Nitrogen Heterocycles and Exocyclic Amino Groups in the Gas Phase and Aqueous Solution. Journal of Chemical Theory and Computation. 4: 1718-1732. PMID 23700392 DOI: 10.1021/ct8000766  1
2008 Chou TF, So C, White BR, Carlson JC, Sarikaya M, Wagner CR. Enzyme nanorings. Acs Nano. 2: 2519-25. PMID 19206287 DOI: 10.1021/nn800577h  1
2008 Li Q, Hapka D, Chen H, Vallera DA, Wagner CR. Self-assembly of antibodies by chemical induction. Angewandte Chemie (International Ed. in English). 47: 10179-82. PMID 19025747 DOI: 10.1002/anie.200803507  1
2008 Liu L, Wagner CR, Hanna PE. Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines. Chemical Research in Toxicology. 21: 2005-16. PMID 18759501 DOI: 10.1021/tx800215h  1
2008 Ghosh P, Cheng J, Chou TF, Jia Y, Avdulov S, Bitterman PB, Polunovsky VA, Wagner CR. Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein. Protein Expression and Purification. 60: 132-9. PMID 18479935 DOI: 10.1016/j.pep.2008.03.024  1
2008 Amidon GL, Wagner CR, Lee KD. A letter from the editors. RE: Impact factors Molecular Pharmaceutics. 5: 472.  1
2007 Chou TF, Sham YY, Wagner CR. Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. Biochemistry. 46: 13074-9. PMID 17939685 DOI: 10.1021/bi701244h  1
2007 Chou TF, Cheng J, Tikh IB, Wagner CR. Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. Journal of Molecular Biology. 373: 978-89. PMID 17870088 DOI: 10.1016/j.jmb.2007.08.023  1
2007 Liu L, Von Vett A, Zhang N, Walters KJ, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2. Chemical Research in Toxicology. 20: 1300-8. PMID 17672512 DOI: 10.1021/tx7001614  1
2007 Minchin RF, Hanna PE, Dupret JM, Wagner CR, Rodrigues-Lima F, Butcher NJ. Arylamine N-acetyltransferase I. The International Journal of Biochemistry & Cell Biology. 39: 1999-2005. PMID 17392017 DOI: 10.1016/j.biocel.2006.12.006  1
2007 Chou TF, Tikh IB, Horta BA, Ghosh B, De Alencastro RB, Wagner CR. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. The Journal of Biological Chemistry. 282: 15137-47. PMID 17337452 DOI: 10.1074/jbc.M606972200  1
2007 Chou TF, Baraniak J, Kaczmarek R, Zhou X, Cheng J, Ghosh B, Wagner CR. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins. Molecular Pharmaceutics. 4: 208-17. PMID 17217311 DOI: 10.1021/mp060070y  1
2007 Chou TF, Wagner CR. Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins. The Journal of Biological Chemistry. 282: 4719-27. PMID 17158446 DOI: 10.1074/jbc.M610530200  1
2006 Choy CJ, Drontle DP, Wagner CR. Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 15.1. PMID 18428952 DOI: 10.1002/0471142700.nc1501s25  1
2006 Poria RB, Norenberg JP, Anderson TL, Erion J, Wagner CR, Arterburn JB, Larson RS. Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia. Cancer Biotherapy & Radiopharmaceuticals. 21: 418-26. PMID 17105416 DOI: 10.1089/cbr.2006.21.418  1
2006 Zhang N, Liu L, Liu F, Wagner CR, Hanna PE, Walters KJ. NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity. Journal of Molecular Biology. 363: 188-200. PMID 16959263 DOI: 10.1016/j.jmb.2006.08.026  1
2006 Liu F, Zhang N, Zhou X, Hanna PE, Wagner CR, Koepp DM, Walters KJ. Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation. Journal of Molecular Biology. 361: 482-92. PMID 16857211 DOI: 10.1016/j.jmb.2006.06.029  1
2006 Carlson JC, Jena SS, Flenniken M, Chou TF, Siegel RA, Wagner CR. Chemically controlled self-assembly of protein nanorings. Journal of the American Chemical Society. 128: 7630-8. PMID 16756320 DOI: 10.1021/ja060631e  1
2005 Wang H, Liu L, Hanna PE, Wagner CR. Catalytic mechanism of hamster arylamine N-acetyltransferase 2. Biochemistry. 44: 11295-306. PMID 16101314 DOI: 10.1021/bi0580310  1
2005 Wang H, Vath GM, Kawamura A, Bates CA, Sim E, Hanna PE, Wagner CR. Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. The Protein Journal. 24: 65-77. PMID 16003948 DOI: 10.1007/s10930-004-1513-9  1
2005 Kim J, Park S, Tretyakova NY, Wagner CR. A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry. Molecular Pharmaceutics. 2: 233-41. PMID 15934784 DOI: 10.1021/mp0500162  1
2005 Ghosh P, Park C, Peterson MS, Bitterman PB, Polunovsky VA, Wagner CR. Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorganic & Medicinal Chemistry Letters. 15: 2177-80. PMID 15808492 DOI: 10.1016/j.bmcl.2005.01.080  1
2005 Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, Oprea T, Chigaev A, Buranda T, Wagner CR, Sklar LA. Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships. Biochemistry. 44: 4322-31. PMID 15766261 DOI: 10.1021/bi048187k  1
2005 Wang H, Wagner CR, Hanna PE. Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes. Chemical Research in Toxicology. 18: 183-97. PMID 15720122 DOI: 10.1021/tx049801w  1
2005 Chou TF, Bieganowski P, Shilinski K, Cheng J, Brenner C, Wagner CR. 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. The Journal of Biological Chemistry. 280: 15356-61. PMID 15703176 DOI: 10.1074/jbc.M500434200  1
2005 Kawamura A, Graham J, Mushtaq A, Tsiftsoglou SA, Vath GM, Hanna PE, Wagner CR, Sim E. Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochemical Pharmacology. 69: 347-59. PMID 15627487 DOI: 10.1016/j.bcp.2004.09.014  1
2004 Wagner CR. A dogma in need of a reformation. Molecular Pharmaceutics. 1: 247. PMID 15981583  1
2004 Kim J, Chou TF, Griesgraber GW, Wagner CR. Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS. Molecular Pharmaceutics. 1: 102-11. PMID 15832506  1
2004 Wang H, Vath GM, Gleason KJ, Hanna PE, Wagner CR. Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies. Biochemistry. 43: 8234-46. PMID 15209520 DOI: 10.1021/bi0497244  1
2004 Drontle DP, Wagner CR. Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines. Mini Reviews in Medicinal Chemistry. 4: 409-19. PMID 15134543  1
2004 Wang H, Guo Z, Vath GM, Wagner CR, Hanna PE. Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents. The Protein Journal. 23: 153-66. PMID 15106881 DOI: 10.1023/B:JOPC.0000020082.14480.e2  1
2004 Kim J, Drontle DP, Wagner CR. Monitoring the intracellular metabolism of nucleoside phosphoramidate pronucleotides by 31P NMR. Nucleosides, Nucleotides & Nucleic Acids. 23: 483-93. PMID 15043168 DOI: 10.1081/NCN-120028341  1
2004 Guo Z, Wagner CR, Hanna PE. Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene. Chemical Research in Toxicology. 17: 275-86. PMID 15025497 DOI: 10.1021/tx030045o  1
2004 Annis DA, Athanasopoulos J, Curran PJ, Felsch JS, Kalghatgi K, Lee WH, Nash HM, Orminati JPA, Rosner KE, Shipps GW, Thaddupathy GRA, Tyler AN, Vilenchik L, Wagner CR, Wintner EA. An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase International Journal of Mass Spectrometry. 238: 77-83. DOI: 10.1016/j.ijms.2003.11.022  1
2003 Guo Z, Vath GM, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene. Journal of Protein Chemistry. 22: 631-42. PMID 14714730 DOI: 10.1023/B:JOPC.0000008728.17159.dd  1
2003 Pineda P, Kanter A, McIvor RS, Benkovic SJ, Rosowsky A, Wagner CR. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. Journal of Medicinal Chemistry. 46: 2816-8. PMID 12825924 DOI: 10.1021/jm034057i  1
2003 Song H, Johns R, Griesgraber GW, Wagner CR, Zimmerman CL. Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate. Pharmaceutical Research. 20: 448-51. PMID 12669967 DOI: 10.1023/A:1022616523678  1
2003 Carlson JC, Kanter A, Thuduppathy GR, Cody V, Pineda PE, McIvor RS, Wagner CR. Designing protein dimerizers: the importance of ligand conformational equilibria. Journal of the American Chemical Society. 125: 1501-7. PMID 12568609 DOI: 10.1021/ja026264y  1
2002 Song H, Griesgraber GW, Wagner CR, Zimmerman CL. Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats. Antimicrobial Agents and Chemotherapy. 46: 1357-63. PMID 11959569 DOI: 10.1128/AAC.46.5.1357-1363.2002  1
2001 Chiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melançon P, Kuchta RD. Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates. Biochemistry. 40: 14260-7. PMID 11714280 DOI: 10.1021/bi011262w  1
2001 McIntee EJ, Wagner CR. Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates. Bioorganic & Medicinal Chemistry Letters. 11: 2803-5. PMID 11597404  1
2001 Chang SL, Griesgraber G, Wagner CR. Comparison of the antiviral activity of hydrophobic amino acid phosphoramidate monoesters of 2'3'-dideoxyadenosine (DDA) and 3'-azido-3'-deoxythymidine (AZT). Nucleosides, Nucleotides & Nucleic Acids. 20: 1571-82. PMID 11554546 DOI: 10.1081/NCN-100105248  1
2001 Chang S, Griesgraber GW, Southern PJ, Wagner CR. Amino acid phosphoramidate monoesters of 3'-azido-3'-deoxythymidine: relationship between antiviral potency and intracellular metabolism. Journal of Medicinal Chemistry. 44: 223-31. PMID 11170632 DOI: 10.1021/jm000260r  1
2000 Wagner CR, Iyer VV, McIntee EJ. Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides. Medicinal Research Reviews. 20: 417-51. PMID 11058891 DOI: 10.1002/1098-1128(200011)20:6<417::AID-MED1>3.0.CO;2-Z  1
2000 Iyer VV, Griesgraber GW, Radmer MR, McIntee EJ, Wagner CR. Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT). Journal of Medicinal Chemistry. 43: 2266-74. PMID 10841805 DOI: 10.1021/jm000110g  1
2000 Chang SL, Griesgraber G, Abraham TW, Garg T, Song H, Zimmerman CL, Wagner CR. Synthesis and antiviral activity of amino acid carbamate derivatives of AZT. Nucleosides, Nucleotides & Nucleic Acids. 19: 87-100. PMID 10772704 DOI: 10.1080/15257770008032998  1
1999 Wagner CR, Chang SL, Griesgraber GW, Song H, McIntee EJ, Zimmerman CL. Antiviral nucleoside drug delivery via amino acid phosphoramidates. Nucleosides & Nucleotides. 18: 913-9. PMID 10432709  1
1998 Sticha KR, Bergstrom CP, Wagner CR, Hanna PE. Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases: bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene. Biochemical Pharmacology. 56: 47-59. PMID 9698088 DOI: 10.1016/S0006-2952(98)00101-4  1
1998 McIntee EJ, Wagner CR, Giordano V, Jeang KT, Chiang PK. Amino acid phosphoramidates of antiviral 3-deazaadenosine analogs exhibit high potency and low cytotoxicity Faseb Journal. 12: A773.  1
1997 Wagner CR, Ballato G, Akanni AO, McIntee EJ, Larson RS, Chang S, Abul-Hajj YJ. Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors. Cancer Research. 57: 2341-5. PMID 9192804  1
1997 Sticha KR, Sieg CA, Bergstrom CP, Hanna PE, Wagner CR. Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein. Protein Expression and Purification. 10: 141-53. PMID 9179301 DOI: 10.1006/prep.1997.0734  1
1997 Wagner CR, McIntee EJ, Chang SL, Zimmerman C. Antiviral nucleotide drug delivery via amino acid phosphoramidates Faseb Journal. 11: A836.  1
1997 Abraham TW, McIntee EJ, Iyer VV, Schinazi RF, Wagner CR. Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir Nucleosides and Nucleotides. 16: 2079-2092.  1
1996 Abraham TW, Kalman TI, McIntee EJ, Wagner CR. Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. Journal of Medicinal Chemistry. 39: 4569-75. PMID 8917645 DOI: 10.1021/jm9603680  1
1996 Wagner CR, Bergstrom CP, Koning KR, Hanna PE. Arylamine N-acetyltransferases. Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 24: 245-53. PMID 8742238  1
1996 Evenson DA, Adams J, McIvor RS, Wagner CR. Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan. Journal of Medicinal Chemistry. 39: 1763-6. PMID 8627598 DOI: 10.1021/jm950793d  1
1995 Bergstrom CP, Wagner CR, Ann DK, Hanna PE. Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification. Protein Expression and Purification. 6: 45-55. PMID 7756838 DOI: 10.1006/prep.1995.1007  1
1995 Wagner CR, Huang Z, Singleton SF, Benkovic SJ. Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase. Biochemistry. 34: 15671-80. PMID 7495797  1
1995 Wagner CR, McIntee EJ, Schinazi RF, Abraham TW. Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication Bioorganic and Medicinal Chemistry Letters. 5: 1819-1824. DOI: 10.1016/0960-894X(95)00302-A  1
1994 Huang Z, Wagner CR, Benkovic SJ. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase. Biochemistry. 33: 11576-85. PMID 7918371  1
1994 Abraham TW, Wagner CR. A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides Nucleosides and Nucleotides. 13: 1891-1903. DOI: 10.1080/15257779408010671  1
1992 Wagner CR, Thillet J, Benkovic SJ. Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange. Biochemistry. 31: 7834-40. PMID 1510969  1
1992 Wagner CR, Benkovic SJ. Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. Journal of Medicinal Chemistry. 35: 2912-5. PMID 1495020  1
1990 Wagner CR, Benkovic SJ. Site directed mutagenesis: a tool for enzyme mechanism dissection. Trends in Biotechnology. 8: 263-70. PMID 1366735 DOI: 10.1016/0167-7799(90)90189-5  1
1988 Wagner CR, Porter NA. A phospholipase C protocol for phospholipid peroxidation analysis. Chemical Research in Toxicology. 1: 274-80. PMID 2979743  1
Show low-probability matches.