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Hashim M. Al-Hashimi - Publications

Affiliations: 
2002-2013 Chemistry and Biophysics University of Michigan, Ann Arbor, Ann Arbor, MI 
 2014- Biochemistry Duke University School of Medicine, Durham, NC, United States 
Area:
Structure and dynamics of nucleic acids and ribonucleoproteins using NMR spectroscopy
Website:
https://www.biochem.duke.edu/hashim-m-al-hashimi-primary
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197 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Geng A, Roy R, Al-Hashimi HM. Conformational penalties: New insights into nucleic acid recognition. Current Opinion in Structural Biology. 89: 102949. PMID 39522437 DOI: 10.1016/j.sbi.2024.102949  0.81
2024 Shin JH, Cuevas LM, Roy R, Bonilla SL, Al-Hashimi H, Greenleaf WJ, Herschlag D. Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs. Rna (New York, N.Y.). PMID 39362695 DOI: 10.1261/rna.080039.124  0.837
2024 Bussi G, Bonomi M, Gkeka P, Sattler M, Al-Hashimi HM, Auffinger P, Duca M, Foricher Y, Incarnato D, Jones AN, Kirmizialtin S, Krepl M, Orozco M, Palermo G, Pasquali S, et al. RNA dynamics from experimental and computational approaches. Structure (London, England : 1993). 32: 1281-1287. PMID 39241758 DOI: 10.1016/j.str.2024.07.019  0.743
2024 Lee Y, Gu S, Al-Hashimi HM. Insights into the A-C mismatch conformational ensemble in duplex DNA and its role in genetic processes through a structure-based review. Journal of Molecular Biology. 168710. PMID 39009073 DOI: 10.1016/j.jmb.2024.168710  0.831
2024 Roy R, Al-Hashimi HM. AlphaFold3 takes a step toward decoding molecular behavior and biological computation. Nature Structural & Molecular Biology. PMID 38977902 DOI: 10.1038/s41594-024-01350-2  0.75
2024 Manghrani A, Rangadurai AK, Szekely O, Liu B, Guseva S, Al-Hashimi HM. Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix. Biorxiv : the Preprint Server For Biology. PMID 38798635 DOI: 10.1101/2024.05.15.594415  0.814
2024 Gu S, Al-Hashimi HM. Direct Measurement of 8OG Syn-Anti Flips in Mutagenic 8OG·A and Long-Range Damage-Dependent Hoogsteen Breathing Dynamics Using H CEST NMR. The Journal of Physical Chemistry. B. PMID 38644782 DOI: 10.1021/acs.jpcb.4c00316  0.778
2024 Gu S, Al-Hashimi HM. Direct Measurement of 8OG Flips in Mutagenic 8OG•A and Long-Range Damage-Dependent Hoogsteen Breathing Dynamics Using H CEST NMR. Biorxiv : the Preprint Server For Biology. PMID 38293035 DOI: 10.1101/2024.01.15.575532  0.778
2024 Szekely O, Rangadurai AK, Gu S, Manghrani A, Guseva S, Al-Hashimi HM. NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: implications for the fidelity of transcription and CRISPR/Cas9 gene editing. Nucleic Acids Research. PMID 38281263 DOI: 10.1093/nar/gkae027  0.847
2023 Geng A, Ganser L, Roy R, Shi H, Pratihar S, Case DA, Al-Hashimi HM. An RNA excited conformational state at atomic resolution. Nature Communications. 14: 8432. PMID 38114465 DOI: 10.1038/s41467-023-43673-6  0.833
2023 Bhai L, Thomas JK, Conroy DW, Xu Y, Al-Hashimi HM, Jaroniec CP. Hydrogen bonding in duplex DNA probed by DNP enhanced solid-state NMR N-H bond length measurements. Frontiers in Molecular Biosciences. 10: 1286172. PMID 38111464 DOI: 10.3389/fmolb.2023.1286172  0.39
2023 Roy R, Geng A, Shi H, Merriman DK, Dethoff EA, Salmon L, Al-Hashimi HM. Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble. Journal of the American Chemical Society. 145: 22964-22978. PMID 37831584 DOI: 10.1021/jacs.3c04614  0.841
2023 Szekely O, Rangadurai AK, Gu S, Manghrani A, Guseva S, Al-Hashimi HM. NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing. Biorxiv : the Preprint Server For Biology. PMID 37662220 DOI: 10.1101/2023.08.24.554670  0.847
2023 Ken ML, Roy R, Geng A, Ganser LR, Manghrani A, Cullen BR, Schulze-Gahmen U, Herschlag D, Al-Hashimi HM. Author Correction: RNA conformational propensities determine cellular activity. Nature. PMID 37296211 DOI: 10.1038/s41586-023-06286-z  0.826
2023 Ken ML, Roy R, Geng A, Ganser LR, Manghrani A, Cullen BR, Schulze-Gahmen U, Herschlag D, Al-Hashimi HM. RNA conformational propensities determine cellular activity. Nature. PMID 37198487 DOI: 10.1038/s41586-023-06080-x  0.828
2023 Gu S, Szymanski ES, Rangadurai AK, Shi H, Liu B, Manghrani A, Al-Hashimi HM. Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs. Nature Chemical Biology. PMID 37095237 DOI: 10.1038/s41589-023-01306-5  0.79
2023 Luo Y, Pratihar S, Horste EH, Mitschka S, Mey ASJS, Al-Hashimi HM, Mayr C. mRNA interactions with disordered regions control protein activity. Biorxiv : the Preprint Server For Biology. PMID 36824771 DOI: 10.1101/2023.02.18.529068  0.793
2022 Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. RBM45 is an mA-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Cell Reports. 40: 111293. PMID 36044854 DOI: 10.1016/j.celrep.2022.111293  0.78
2022 Conroy DW, Xu Y, Shi H, Gonzalez Salguero N, Purusottam RN, Shannon MD, Al-Hashimi HM, Jaroniec CP. Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200681119. PMID 35857870 DOI: 10.1073/pnas.2200681119  0.763
2022 Rangadurai A, Shi H, Xu Y, Liu B, Abou Assi H, Boom JD, Zhou H, Kimsey IJ, Al-Hashimi HM. Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting. Proceedings of the National Academy of Sciences of the United States of America. 119: e2112496119. PMID 35671421 DOI: 10.1073/pnas.2112496119  0.836
2022 Lai LB, Lai SM, Szymanski ES, Kapur M, Choi EK, Al-Hashimi HM, Ackerman SL, Gopalan V. Structural basis for impaired 5' processing of a mutant tRNA associated with defects in neuronal homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 119: e2119529119. PMID 35238631 DOI: 10.1073/pnas.2119529119  0.794
2021 Liu B, Rangadurai A, Shi H, Al-Hashimi HM. Rapid assessment of Watson-Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino H CEST. Magnetic Resonance (Gottingen, Germany). 2: 715-731. PMID 37905209 DOI: 10.5194/mr-2-715-2021  0.816
2021 Shi H, Kimsey IJ, Gu S, Liu HF, Pham U, Schumacher MA, Al-Hashimi HM. Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA. Nucleic Acids Research. PMID 34792150 DOI: 10.1093/nar/gkab936  0.799
2021 Liu B, Shi H, Rangadurai A, Nussbaumer F, Chu CC, Erharter KA, Case DA, Kreutz C, Al-Hashimi HM. A quantitative model predicts how mA reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions. Nature Communications. 12: 5201. PMID 34465779 DOI: 10.1038/s41467-021-25253-8  0.83
2021 Liu B, Shi H, Al-Hashimi HM. Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids. Current Opinion in Structural Biology. 70: 16-25. PMID 33836446 DOI: 10.1016/j.sbi.2021.02.007  0.761
2020 Shi H, Rangadurai A, Abou Assi H, Roy R, Case DA, Herschlag D, Yesselman JD, Al-Hashimi HM. Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction. Nature Communications. 11: 5531. PMID 33139729 DOI: 10.1038/s41467-020-19371-y  0.849
2020 Abou Assi H, Rangadurai AK, Shi H, Liu B, Clay MC, Erharter K, Kreutz C, Holley CL, Al-Hashimi HM. 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states. Nucleic Acids Research. PMID 33104789 DOI: 10.1093/nar/gkaa928  0.84
2020 Afek A, Shi H, Rangadurai A, Sahay H, Senitzki A, Xhani S, Fang M, Salinas R, Mielko Z, Pufall MA, Poon GMK, Haran TE, Schumacher MA, Al-Hashimi HM, Gordân R. DNA mismatches reveal conformational penalties in protein-DNA recognition. Nature. PMID 33087930 DOI: 10.1038/s41586-020-2843-2  0.804
2020 Kelly ML, Chu CC, Shi H, Ganser LR, Bogerd HP, Huynh K, Hou Y, Cullen BR, Al-Hashimi HM. Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays. Rna (New York, N.Y.). PMID 33028652 DOI: 10.1261/rna.076257.120  0.834
2020 Xu Y, Manghrani A, Liu B, Shi H, Pham U, Liu A, Al-Hashimi HM. Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage. The Journal of Biological Chemistry. PMID 32913127 DOI: 10.1074/Jbc.Ra120.014530  0.806
2020 Rangadurai A, Szymanski ES, Kimsey I, Shi H, Al-Hashimi HM. Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R relaxation dispersion. Journal of Biomolecular Nmr. PMID 32789613 DOI: 10.1007/S10858-020-00337-7  0.833
2020 Li P, Rangadurai A, Al-Hashimi HM, Hammes-Schiffer S. Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations. Journal of the American Chemical Society. PMID 32459476 DOI: 10.1021/Jacs.0C03774  0.722
2020 Kladwang W, Topkar V, Liu B, Rangan R, Hodges T, Keane S, Al-Hashimi HM, Das R. Anomalous reverse transcription through chemical modifications in polyadenosine stretches. Biochemistry. PMID 32407625 DOI: 10.1021/Acs.Biochem.0C00020  0.466
2020 Ganser LR, Lee J, Rangadurai A, Merriman DK, Kelly ML, Kansal AD, Sathyamoorthy B, Al-Hashimi HM. Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble. Nature Structural & Molecular Biology. PMID 32376863 DOI: 10.1038/S41594-020-0434-4  0.806
2020 Rangadurai A, Shi H, Al-Hashimi HM. Extending the Sensitivity of CEST to Micro-to-Millisecond Dynamics in Nucleic Acids Using High Power Radio-Frequency Fields. Angewandte Chemie (International Ed. in English). PMID 32168407 DOI: 10.1002/Anie.202000493  0.79
2020 Ganser LR, Chu CC, Bogerd HP, Kelly ML, Cullen BR, Al-Hashimi HM. Probing RNA Conformational Equilibria within the Functional Cellular Context. Cell Reports. 30: 2472-2480.e4. PMID 32101729 DOI: 10.1016/J.Celrep.2020.02.004  0.846
2020 Rangadurai A, Shi H, Al-Hashimi HM. Extending the Sensitivity of CEST to Micro‐to‐Millisecond Dynamics in Nucleic Acids Using High Power Radio‐Frequency Fields Angewandte Chemie. DOI: 10.1002/Ange.202000493  0.779
2019 Ganser LR, Kelly ML, Patwardhan NN, Hargrove AE, Al-Hashimi HM. Demonstration that small molecules can bind and stabilize low-abundance short-lived RNA excited conformational states. Journal of Molecular Biology. PMID 31863746 DOI: 10.1016/J.Jmb.2019.12.009  0.852
2019 Shi H, Liu B, Nussbaumer F, Rangadurai A, Kreutz C, Al-Hashimi HM. NMR chemical exchange measurements reveal that N6-methyladenosine slows RNA annealing. Journal of the American Chemical Society. PMID 31826614 DOI: 10.1021/Jacs.9B10939  0.858
2019 Chu CC, Liu B, Plangger R, Kreutz C, Al-Hashimi HM. m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB. Plos One. 14: e0224850. PMID 31825959 DOI: 10.1371/Journal.Pone.0224850  0.5
2019 Orlovsky NI, Al-Hashimi HM, Oas TG. Exposing hidden high-affinity RNA conformational states. Journal of the American Chemical Society. PMID 31815464 DOI: 10.1021/Jacs.9B10535  0.504
2019 Rangadurai A, Kremser J, Shi H, Kreutz C, Al-Hashimi HM. Direct evidence for (G)O6···H-N4(C) hydrogen bonding in transient G(syn)-C and G(syn)-mC Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R relaxation dispersion measurements. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 308: 106589. PMID 31539864 DOI: 10.1016/J.Jmr.2019.106589  0.814
2019 Rangadurai A, Szymaski ES, Kimsey IJ, Shi H, Al-Hashimi HM. Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R relaxation dispersion. Progress in Nuclear Magnetic Resonance Spectroscopy. 112: 55-102. PMID 31481159 DOI: 10.1016/J.Pnmrs.2019.05.002  0.812
2019 Chu CC, Plangger R, Kreutz C, Al-Hashimi HM. Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site. Nucleic Acids Research. PMID 31199872 DOI: 10.1093/Nar/Gkz498  0.475
2019 Ganser LR, Kelly ML, Herschlag D, Al-Hashimi HM. The roles of structural dynamics in the cellular functions of RNAs. Nature Reviews. Molecular Cell Biology. PMID 31182864 DOI: 10.1038/S41580-019-0136-0  0.851
2019 Zhou H, Sathyamoorthy B, Stelling A, Xu Y, Xue Y, Pigli YZ, Case DA, Rice PA, Al-Hashimi HM. Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically C- and N-Labeled DNA. Biochemistry. PMID 30950607 DOI: 10.1021/Acs.Biochem.9B00027  0.824
2019 Fick RJ, Horowitz S, McDole BG, Clay MC, Mehl RA, Al-Hashimi HM, Scheiner S, Trievel RC. Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. Biochemistry. PMID 30810306 DOI: 10.1021/Acs.Biochem.8B01141  0.666
2019 Shi H, Liu B, Rangadurai A, Clay M, Kreutz C, Al-Hashimi H. Visualizing Base Opening in Nucleic Acid Duplexes Biophysical Journal. 116: 359a. DOI: 10.1016/J.Bpj.2018.11.1955  0.774
2019 Kaushik Rangadurai A, Szymanski ES, Shi H, Al-Hashimi HM. Watson-Crick Like Mismatches in Replication Fidelity Biophysical Journal. 116: 359a. DOI: 10.1016/J.Bpj.2018.11.1953  0.792
2018 Travis B, Shaw PLR, Liu B, Ravindra K, Iliff H, Al-Hashimi HM, Schumacher MA. The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA. Nucleic Acids Research. PMID 30544166 DOI: 10.2210/Pdb6E4O/Pdb  0.494
2018 Strebitzer E, Rangadurai A, Plangger R, Kremser J, Juen MA, Tollinger M, Al-Hashimi HM, Kreutz C. 5-Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson-Crick like cmo U-G Base Pairs. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30300940 DOI: 10.1002/Chem.201805077  0.762
2018 Rangadurai A, Zhou H, Merriman DK, Meiser N, Liu B, Shi H, Szymanski ES, Al-Hashimi HM. Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA? Nucleic Acids Research. PMID 30285154 DOI: 10.1093/Nar/Gky885  0.841
2018 Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM. A potentially abundant junctional RNA motif stabilized by mA and Mg. Nature Communications. 9: 2761. PMID 30018356 DOI: 10.1038/S41467-018-05243-Z  0.802
2018 Merriman DK, Yuan J, Shi H, Majumdar A, Herschlag D, Al-Hashimi HM. Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics. Rna (New York, N.Y.). PMID 30012568 DOI: 10.1261/Rna.066258.118  0.845
2018 Fick RJ, Clay MC, Vander Lee L, Scheiner S, Al-Hashimi HM, Trievel RC. Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates AdoMet Recognition in the Reactivation Domain of Cobalamin-dependent Methionine Synthase. Biochemistry. PMID 29733595 DOI: 10.1021/Acs.Biochem.8B00375  0.301
2018 Ganser LR, Lee J, Rangadurai A, Merriman DK, Kelly ML, Kansal AD, Sathyamoorthy B, Al-Hashimi HM. High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble. Nature Structural & Molecular Biology. 25: 425-434. PMID 29728655 DOI: 10.1038/S41594-018-0062-4  0.823
2018 Shi H, Clay MC, Rangadurai A, Sathyamoorthy B, Case DA, Al-Hashimi HM. Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations. Journal of Biomolecular Nmr. PMID 29675775 DOI: 10.1007/S10858-018-0177-2  0.824
2018 Xu Y, McSally J, Andricioaei I, Al-Hashimi HM. Modulation of Hoogsteen dynamics on DNA recognition. Nature Communications. 9: 1473. PMID 29662229 DOI: 10.1038/S41467-018-03516-1  0.524
2018 Gracia B, Al-Hashimi HM, Bisaria N, Das R, Herschlag D, Russell R. Hidden Structural Modules in a Cooperative RNA Folding Transition. Cell Reports. 22: 3240-3250. PMID 29562180 DOI: 10.1016/J.Celrep.2018.02.101  0.517
2018 Kimsey IJ, Szymanski ES, Zahurancik WJ, Shakya A, Xue Y, Chu CC, Sathyamoorthy B, Suo Z, Al-Hashimi HM. Dynamic basis for dG•dT misincorporation via tautomerization and ionization. Nature. 554: 195-201. PMID 29420478 DOI: 10.1038/Nature25487  0.8
2017 Salmon L, Stull F, Sayle S, Cato C, Akgül Ş, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. The Mechanism of HdeA Unfolding and Chaperone Activation. Journal of Molecular Biology. PMID 29138002 DOI: 10.1016/J.Jmb.2017.11.002  0.801
2017 Patwardhan NN, Ganser LR, Kapral GJ, Eubanks CS, Lee J, Sathyamoorthy B, Al-Hashimi HM, Hargrove AE. Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR. Medchemcomm. 8: 1022-1036. PMID 28798862 DOI: 10.1039/C6Md00729E  0.831
2017 Clay MC, Ganser LR, Merriman DK, Al-Hashimi HM. Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics. Nucleic Acids Research. PMID 28609788 DOI: 10.1093/Nar/Gkx525  0.855
2017 Stelling AL, Xu Y, Zhou H, Choi SH, Clay MC, Merriman DK, Al-Hashimi HM. Robust IR Based Detection of Stable and Fractionally Populated G-C(+) and A-T Hoogsteen Base Pairs in Duplex DNA. Febs Letters. PMID 28524232 DOI: 10.1002/1873-3468.12681  0.807
2017 Sathyamoorthy B, Shi H, Zhou H, Xue Y, Rangadurai A, Merriman DK, Al-Hashimi HM. Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A. Nucleic Acids Research. PMID 28369571 DOI: 10.1093/Nar/Gkx186  0.82
2017 Szymanski ES, Kimsey IJ, Al-Hashimi HM. Direct NMR Evidence that Transient Tautomeric and Anionic States in dG•dT Form Watson-Crick like Base Pairs. Journal of the American Chemical Society. PMID 28290687 DOI: 10.1021/Jacs.7B01156  0.828
2017 Vaidyanathan PP, AlSadhan I, Merriman DK, Al-Hashimi H, Herschlag D. Pseudouridine and N-6 methyladenosine modifications weaken PUF protein/RNA interactions. Rna (New York, N.Y.). PMID 28138061 DOI: 10.1261/Rna.060053.116  0.794
2017 Szymanski ES, Kimsey IJ, Al-Hashimi HM. Role of Watson-Crick-Like Mismatches in DNA Replication Fidelity Biophysical Journal. 112: 70a. DOI: 10.1016/J.Bpj.2016.11.419  0.815
2017 Stelling AL, Al-Hashimi H. Exploring DNA and RNA Structures in Solution with Infrared Spectroscopy Biophysical Journal. 112: 474a. DOI: 10.1016/J.Bpj.2016.11.2545  0.475
2016 Shakya A, Al-Hashimi HM, Banaszak Holl MM. Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies. Acs Macro Letters. 5: 1104-1108. PMID 35658189 DOI: 10.1021/acsmacrolett.6b00668  0.814
2016 Ganser LR, Al-Hashimi HM. HIV-1 leader RNA dimeric interface revealed by NMR. Proceedings of the National Academy of Sciences of the United States of America. PMID 27837023 DOI: 10.1073/Pnas.1615789113  0.795
2016 Zhou H, Kimsey IJ, Nikolova EN, Sathyamoorthy B, Grazioli G, McSally J, Bai T, Wunderlich CH, Kreutz C, Andricioaei I, Al-Hashimi HM. m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs. Nature Structural & Molecular Biology. PMID 27478929 DOI: 10.1038/Nsmb.3270  0.85
2016 Gracia B, Xue Y, Bisaria N, Herschlag D, Al-Hashimi HM, Russell R. RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly. Journal of Molecular Biology. PMID 27452365 DOI: 10.1016/J.Jmb.2016.07.013  0.639
2016 Xue Y, Gracia B, Herschlag D, Russell R, Al-Hashimi HM. Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch. Nature Communications. 7: ncomms11768. PMID 27292179 DOI: 10.1038/Ncomms11768  0.645
2016 Merriman DK, Xue Y, Yang S, Kimsey IJ, Shakya A, Clay MC, Al-Hashimi HM. Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes Over a Broad Range of Timescales. Biochemistry. PMID 27232530 DOI: 10.1021/Acs.Biochem.6B00285  0.842
2016 Shakya A, Al-Hashimi HM, Banaszak Holl MM. Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies Acs Macro Letters. 5: 1104-1108. DOI: 10.1021/Acsmacrolett.6B00668  0.825
2015 Ren A, Xue Y, Peselis A, Serganov A, Al-Hashimi HM, Patel DJ. Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Reports. 13: 1800-1813. PMID 26655897 DOI: 10.1016/J.Celrep.2015.10.062  0.798
2015 Shakya A, Dougherty CA, Xue Y, Al-Hashimi HM, Banaszak Holl MM. Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. Biomacromolecules. PMID 26595195 DOI: 10.1021/Acs.Biomac.5B01280  0.848
2015 Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, ... ... Al-Hashimi HM, et al. Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity. Cell. 163: 746-58. PMID 26496612 DOI: 10.1016/J.Cell.2015.09.056  0.79
2015 Mustoe AM, Al-Hashimi HM, Brooks CL. Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme. Nucleic Acids Research. PMID 26481360 DOI: 10.1093/Nar/Gkv1055  0.773
2015 Andrałojć W, Ravera E, Salmon L, Parigi G, Al-Hashimi HM, Luchinat C. Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations. Physical Chemistry Chemical Physics : Pccp. PMID 26360616 DOI: 10.1039/C5Cp03993B  0.75
2015 Salmon L, Giambaşu GM, Nikolova EN, Petzold K, Bhattacharya A, Case DA, Al-Hashimi HM. Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings. Journal of the American Chemical Society. PMID 26306428 DOI: 10.1021/Jacs.5B07229  0.834
2015 Yang S, Al-Hashimi HM. Unveiling Inherent Degeneracies in Determining Population-weighted Ensembles of Inter-domain Orientational Distributions Using NMR Residual Dipolar Couplings: Application to RNA Helix Junction Helix Motifs. The Journal of Physical Chemistry. B. PMID 26131693 DOI: 10.1021/Acs.Jpcb.5B03859  0.594
2015 Kimsey IJ, Zhou H, Alvey H, Al-Hashimi HM. 120 Role of dynamic base pair polymorphism in the central dogma of molecular biology. Journal of Biomolecular Structure & Dynamics. 33: 75-6. PMID 26103330 DOI: 10.1080/07391102.2015.1032753  0.79
2015 Frank AT, Zhang Q, Al-Hashimi HM, Andricioaei I. Slowdown of Interhelical Motions Induces a Glass Transition in RNA. Biophysical Journal. 108: 2876-85. PMID 26083927 DOI: 10.1016/J.Bpj.2015.04.041  0.495
2015 Xue Y, Kellogg D, Kimsey IJ, Sathyamoorthy B, Stein ZW, McBrairty M, Al-Hashimi HM. Characterizing RNA Excited States Using NMR Relaxation Dispersion. Methods in Enzymology. 558: 39-73. PMID 26068737 DOI: 10.1016/Bs.Mie.2015.02.002  0.838
2015 Zhou H, Hintze BJ, Kimsey IJ, Sathyamoorthy B, Yang S, Richardson JS, Al-Hashimi HM. New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey. Nucleic Acids Research. 43: 3420-33. PMID 25813047 DOI: 10.1093/Nar/Gkv241  0.805
2015 Kimsey IJ, Petzold K, Sathyamoorthy B, Stein ZW, Al-Hashimi HM. Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes. Nature. 519: 315-20. PMID 25762137 DOI: 10.1038/Nature14227  0.845
2015 Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL. Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. Journal of the American Chemical Society. 137: 3592-9. PMID 25705930 DOI: 10.1021/Ja5130308  0.778
2015 Mouzakis KD, Dethoff EA, Tonelli M, Al-Hashimi H, Butcher SE. Dynamic motions of the HIV-1 frameshift site RNA. Biophysical Journal. 108: 644-54. PMID 25650931 DOI: 10.1016/J.Bpj.2014.12.006  0.842
2014 Nikolova EN, Stull F, Al-Hashimi HM. Guanine to inosine substitution leads to large increases in the population of a transient G·C Hoogsteen base pair. Biochemistry. 53: 7145-7. PMID 25339065 DOI: 10.1021/Bi5011909  0.768
2014 Ganser LR, Mustoe AM, Al-Hashimi HM. An RNA tertiary switch by modifying how helices are tethered. Genome Biology. 15: 425. PMID 25315677 DOI: 10.1186/S13059-014-0425-Z  0.827
2014 Mustoe AM, Brooks CL, Al-Hashimi HM. Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity. Nucleic Acids Research. 42: 11792-804. PMID 25217593 DOI: 10.1093/Nar/Gku807  0.79
2014 Sathyamoorthy B, Lee J, Kimsey I, Ganser LR, Al-Hashimi H. Development and application of aromatic [(13)C, (1)H] SOFAST-HMQC NMR experiment for nucleic acids. Journal of Biomolecular Nmr. 60: 77-83. PMID 25186910 DOI: 10.1007/S10858-014-9856-9  0.787
2014 Alvey HS, Gottardo FL, Nikolova EN, Al-Hashimi HM. Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics. Nature Communications. 5: 4786. PMID 25185517 DOI: 10.1038/Ncomms5786  0.81
2014 Ravera E, Salmon L, Fragai M, Parigi G, Al-Hashimi H, Luchinat C. Insights into domain-domain motions in proteins and RNA from solution NMR. Accounts of Chemical Research. 47: 3118-26. PMID 25148413 DOI: 10.1021/Ar5002318  0.718
2014 Lee J, Dethoff EA, Al-Hashimi HM. Invisible RNA state dynamically couples distant motifs. Proceedings of the National Academy of Sciences of the United States of America. 111: 9485-90. PMID 24979799 DOI: 10.1073/Pnas.1407969111  0.856
2014 Horowitz S, Adhikari U, Dirk LM, Del Rizzo PA, Mehl RA, Houtz RL, Al-Hashimi HM, Scheiner S, Trievel RC. Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. Acs Chemical Biology. 9: 1692-7. PMID 24914947 DOI: 10.1021/Cb5001185  0.667
2014 Bothe JR, Stein ZW, Al-Hashimi HM. Evaluating the uncertainty in exchange parameters determined from off-resonance R1ρ relaxation dispersion for systems in fast exchange. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 244: 18-29. PMID 24819426 DOI: 10.1016/J.Jmr.2014.04.010  0.73
2014 Zeng X, Chugh J, Casiano-Negroni A, Al-Hashimi HM, Brooks CL. Flipping of the ribosomal A-site adenines provides a basis for tRNA selection. Journal of Molecular Biology. 426: 3201-13. PMID 24813122 DOI: 10.1016/J.Jmb.2014.04.029  0.701
2014 Eichhorn CD, Al-Hashimi HM. Structural dynamics of a single-stranded RNA-helix junction using NMR. Rna (New York, N.Y.). 20: 782-91. PMID 24742933 DOI: 10.1261/Rna.043711.113  0.824
2014 Kimsey I, Al-Hashimi HM. Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids. Current Opinion in Structural Biology. 24: 72-80. PMID 24721455 DOI: 10.1016/J.Sbi.2013.12.003  0.79
2014 Yang S, Salmon L, Al-Hashimi HM. Measuring similarity between dynamic ensembles of biomolecules. Nature Methods. 11: 552-4. PMID 24705474 DOI: 10.1038/Nmeth.2921  0.783
2014 Mustoe AM, Brooks CL, Al-Hashimi HM. Hierarchy of RNA functional dynamics. Annual Review of Biochemistry. 83: 441-66. PMID 24606137 DOI: 10.1146/Annurev-Biochem-060713-035524  0.776
2014 Mustoe AM, Al-Hashimi HM, Brooks CL. Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges. The Journal of Physical Chemistry. B. 118: 2615-27. PMID 24547945 DOI: 10.1021/Jp411478X  0.804
2014 Salmon L, Yang S, Al-Hashimi HM. Advances in the determination of nucleic acid conformational ensembles. Annual Review of Physical Chemistry. 65: 293-316. PMID 24364917 DOI: 10.1146/Annurev-Physchem-040412-110059  0.793
2014 Hintze B, Zhou H, Al-Hashimi H, Richardson D, Richardson J. Hidden Hoogsteens in the Data Acta Crystallographica Section a Foundations and Advances. 70: C1508-C1508. DOI: 10.1107/S2053273314084915  0.355
2014 Mustoe AM, Al-Hashimi HM, Brooks CL. Linking RNA Secondary Structure to the Free Energy of Tertiary Structure Folding through Coarse-Grained Models Biophysical Journal. 106: 284a. DOI: 10.1016/J.Bpj.2013.11.1661  0.795
2014 Sathyamoorthy B, Lee J, Kimsey I, Ganser LR, Al-Hashimi H. Development and application of aromatic [13C, 1H] SOFAST-HMQC NMR experiment for nucleic acids Journal of Biomolecular Nmr. DOI: 10.1007/s10858-014-9856-9  0.775
2013 Al-Hashimi HM. NMR studies of nucleic acid dynamics. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 237: 191-204. PMID 24149218 DOI: 10.1016/J.Jmr.2013.08.014  0.409
2013 Horowitz S, Dirk LM, Yesselman JD, Nimtz JS, Adhikari U, Mehl RA, Scheiner S, Houtz RL, Al-Hashimi HM, Trievel RC. Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. Journal of the American Chemical Society. 135: 15536-48. PMID 24093804 DOI: 10.1021/Ja407140K  0.786
2013 Suddala KC, Rinaldi AJ, Feng J, Mustoe AM, Eichhorn CD, Liberman JA, Wedekind JE, Al-Hashimi HM, Brooks CL, Walter NG. Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic Acids Research. 41: 10462-75. PMID 24003028 DOI: 10.1093/Nar/Gkt798  0.833
2013 Lee J, Vogt CE, McBrairty M, Al-Hashimi HM. Influence of dimethylsulfoxide on RNA structure and ligand binding. Analytical Chemistry. 85: 9692-8. PMID 23987474 DOI: 10.1021/Ac402038T  0.813
2013 Nikolova EN, Zhou H, Gottardo FL, Alvey HS, Kimsey IJ, Al-Hashimi HM. A historical account of hoogsteen base-pairs in duplex DNA. Biopolymers. 99: 955-68. PMID 23818176 DOI: 10.1002/Bip.22334  0.808
2013 Nikolova EN, Goh GB, Brooks CL, Al-Hashimi HM. Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA. Journal of the American Chemical Society. 135: 6766-9. PMID 23506098 DOI: 10.1021/Ja400994E  0.773
2013 Salmon L, Bascom G, Andricioaei I, Al-Hashimi HM. A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed. Journal of the American Chemical Society. 135: 5457-66. PMID 23473378 DOI: 10.1021/Ja400920W  0.761
2013 Frank AT, Horowitz S, Andricioaei I, Al-Hashimi HM. Utility of 1H NMR chemical shifts in determining RNA structure and dynamics. The Journal of Physical Chemistry. B. 117: 2045-52. PMID 23320790 DOI: 10.1021/Jp310863C  0.759
2012 Dethoff EA, Petzold K, Chugh J, Casiano-Negroni A, Al-Hashimi HM. Visualizing transient low-populated structures of RNA. Nature. 491: 724-8. PMID 23041928 DOI: 10.1038/Nature11498  0.849
2012 Nikolova EN, Bascom GD, Andricioaei I, Al-Hashimi HM. Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations. Biochemistry. 51: 8654-64. PMID 23035755 DOI: 10.1021/Bi3009517  0.782
2012 Bothe JR, Lowenhaupt K, Al-Hashimi HM. Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation. Biochemistry. 51: 6871-9. PMID 22873788 DOI: 10.1021/Bi300785B  0.741
2012 Prevette LE, Nikolova EN, Al-Hashimi HM, Banaszak Holl MM. Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release. Molecular Pharmaceutics. 9: 2743-9. PMID 22823140 DOI: 10.1021/Mp3002864  0.763
2012 Dethoff EA, Chugh J, Mustoe AM, Al-Hashimi HM. Functional complexity and regulation through RNA dynamics. Nature. 482: 322-30. PMID 22337051 DOI: 10.1038/Nature10885  0.844
2012 Nikolova EN, Gottardo FL, Al-Hashimi HM. Probing transient Hoogsteen hydrogen bonds in canonical duplex DNA using NMR relaxation dispersion and single-atom substitution. Journal of the American Chemical Society. 134: 3667-70. PMID 22309937 DOI: 10.1021/Ja2117816  0.759
2012 Eichhorn CD, Feng J, Suddala KC, Walter NG, Brooks CL, Al-Hashimi HM. Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. Nucleic Acids Research. 40: 1345-55. PMID 22009676 DOI: 10.1093/Nar/Gkr833  0.836
2012 Mustoe AM, Bailor MH, Teixeira RM, Brooks CL, Al-Hashimi HM. New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation. Nucleic Acids Research. 40: 892-904. PMID 21937512 DOI: 10.1093/Nar/Gkr751  0.848
2012 Pedini HS, Al-Hashimi HM. Examining the Impact of Supercoiling on Sequence-Dependent DNA Structure and Flexibility Biophysical Journal. 102: 392a. DOI: 10.1016/J.Bpj.2011.11.2139  0.35
2012 Eichhorn CD, Yang S, Al-Hashimi HM. Characterising RNA dynamics using NMR residual dipolar couplings Rsc Biomolecular Sciences. 184-215.  0.815
2011 Petzold K, Al-Hashimi HM. RNA structure: Adding a second dimension. Nature Chemistry. 3: 913-5. PMID 22109268 DOI: 10.1038/Nchem.1209  0.745
2011 Bothe JR, Nikolova EN, Eichhorn CD, Chugh J, Hansen AL, Al-Hashimi HM. Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. Nature Methods. 8: 919-31. PMID 22036746 DOI: 10.1038/Nmeth.1735  0.851
2011 Bailor MH, Mustoe AM, Brooks CL, Al-Hashimi HM. 3D maps of RNA interhelical junctions. Nature Protocols. 6: 1536-45. PMID 21959236 DOI: 10.1038/Nprot.2011.385  0.815
2011 Stelzer AC, Frank AT, Kratz JD, Swanson MD, Gonzalez-Hernandez MJ, Lee J, Andricioaei I, Markovitz DM, Al-Hashimi HM. Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nature Chemical Biology. 7: 553-9. PMID 21706033 DOI: 10.1038/Nchembio.596  0.817
2011 Bailor MH, Mustoe AM, Brooks CL, Al-Hashimi HM. Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation. Current Opinion in Structural Biology. 21: 296-305. PMID 21497083 DOI: 10.1016/J.Sbi.2011.03.009  0.853
2011 Horowitz S, Yesselman JD, Al-Hashimi HM, Trievel RC. Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. The Journal of Biological Chemistry. 286: 18658-63. PMID 21454678 DOI: 10.1074/Jbc.M111.232876  0.779
2011 Bothe JR, Lowenhaupt K, Al-Hashimi HM. Sequence-specific B-DNA flexibility modulates Z-DNA formation. Journal of the American Chemical Society. 133: 2016-8. PMID 21275369 DOI: 10.1021/Ja1073068  0.734
2011 Nikolova EN, Kim E, Wise AA, O'Brien PJ, Andricioaei I, Al-Hashimi HM. Transient Hoogsteen base pairs in canonical duplex DNA. Nature. 470: 498-502. PMID 21270796 DOI: 10.1038/Nature09775  0.781
2011 Horowitz S, Al-Hashimi H, Trievel R. Evidence for Carbon-Oxygen Hydrogen Bonding in Lysine Methyltransferase Set7/9 by NMR Chemical Shift Biophysical Journal. 100: 66a. DOI: 10.1016/J.Bpj.2010.12.560  0.661
2011 Chugh J, Casiano-Negroni A, Al-Hashimi HM. NMR Dissection of the Detailed Mechanism for Antibiotic Binding to Asite RNA Biophysical Journal. 100: 603a. DOI: 10.1016/J.Bpj.2010.12.3473  0.781
2011 Mustoe AM, Al-Hashimi HM, Brooks CL. A Coarse Grain RNA Model for Exploration of RNA Conformational Space Biophysical Journal. 100: 238a. DOI: 10.1016/J.Bpj.2010.12.1518  0.81
2011 Dethoff EA, Al-Hashimi HM. Characterization of ps-Ms Dynamics in the TAR Apical Loop by NMR Biophysical Journal. 100: 238a. DOI: 10.1016/J.Bpj.2010.12.1515  0.818
2011 Yesselman JD, Al-Hashimi HM, Brooks CL. Exploring RNA Drug Binding Using Consistent Charge Models Biophysical Journal. 100: 159a. DOI: 10.1016/J.Bpj.2010.12.1085  0.784
2010 Dethoff EA, Al-Hashimi HM. A rare example of lock-and-key RNA recognition. Journal of Molecular Biology. 404: 553-4. PMID 20951707 DOI: 10.1016/J.Jmb.2010.10.014  0.826
2010 Nikolova EN, Al-Hashimi HM. Thermodynamics of RNA melting, one base pair at a time. Rna (New York, N.Y.). 16: 1687-91. PMID 20660079 DOI: 10.1261/Rna.2235010  0.82
2010 Stelzer AC, Kratz JD, Zhang Q, Al-Hashimi HM. RNA dynamics by design: biasing ensembles towards the ligand-bound state. Angewandte Chemie (International Ed. in English). 49: 5731-3. PMID 20583015 DOI: 10.1002/Anie.201000814  0.84
2010 Buer BC, Chugh J, Al-Hashimi HM, Marsh EN. Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. Biochemistry. 49: 5760-5. PMID 20527804 DOI: 10.1021/Bi100605E  0.666
2010 Koutmou KS, Casiano-Negroni A, Getz MM, Pazicni S, Andrews AJ, Penner-Hahn JE, Al-Hashimi HM, Fierke CA. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proceedings of the National Academy of Sciences of the United States of America. 107: 2479-84. PMID 20133747 DOI: 10.1073/Pnas.0906319107  0.792
2010 Bailor MH, Sun X, Al-Hashimi HM. Topology links RNA secondary structure with global conformation, dynamics, and adaptation. Science (New York, N.Y.). 327: 202-6. PMID 20056889 DOI: 10.1126/Science.1181085  0.854
2010 Musselman C, Zhang Q, Al-Hashimi H, Andricioaei I. Referencing strategy for the direct comparison of nuclear magnetic resonance and molecular dynamics motional parameters in RNA. The Journal of Physical Chemistry. B. 114: 929-39. PMID 20039757 DOI: 10.1021/Jp905286H  0.711
2010 Dethoff EA, Hansen AL, Zhang Q, Al-Hashimi HM. Variable helix elongation as a tool to modulate RNA alignment and motional couplings. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 202: 117-21. PMID 19854083 DOI: 10.1016/J.Jmr.2009.09.022  0.842
2010 Stelzer AC, Frazee RW, Van Huis C, Cleary J, Opipari AW, Glick GD, Al-Hashimi HM. NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers. 93: 85-92. PMID 19768783 DOI: 10.1002/Bip.21306  0.775
2010 Stelzer A, Kratz J, Zhang Q, Al-Hashimi H. Cover Picture: RNA Dynamics by Design: Biasing Ensembles Towards the Ligand-Bound State (Angew. Chem. Int. Ed. 33/2010) Angewandte Chemie International Edition. 49: 5583-5583. DOI: 10.1002/Anie.201003852  0.815
2010 Stelzer A, Kratz J, Zhang Q, Al-Hashimi H. Titelbild: RNA Dynamics by Design: Biasing Ensembles Towards the Ligand-Bound State (Angew. Chem. 33/2010) Angewandte Chemie. 122: 5715-5715. DOI: 10.1002/Ange.201003852  0.815
2009 Zhang Q, Al-Hashimi HM. Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition. Rna (New York, N.Y.). 15: 1941-8. PMID 19776156 DOI: 10.1261/Rna.1806909  0.561
2009 Stelzer AC, Frank AT, Bailor MH, Andricioaei I, Al-Hashimi HM. Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs. Methods (San Diego, Calif.). 49: 167-73. PMID 19699798 DOI: 10.1016/J.Ymeth.2009.08.006  0.849
2009 Al-Hashimi HM. Structural biology: Aerial view of the HIV genome. Nature. 460: 696-8. PMID 19661906 DOI: 10.1038/460696A  0.35
2009 Nikolova EN, Al-Hashimi HM. Preparation, resonance assignment, and preliminary dynamics characterization of residue specific 13C/15N-labeled elongated DNA for the study of sequence-directed dynamics by NMR. Journal of Biomolecular Nmr. 45: 9-16. PMID 19636798 DOI: 10.1007/S10858-009-9350-Y  0.781
2009 Frank AT, Stelzer AC, Al-Hashimi HM, Andricioaei I. Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition. Nucleic Acids Research. 37: 3670-9. PMID 19369218 DOI: 10.1093/Nar/Gkp156  0.829
2009 Fisher CK, Al-Hashimi HM. Approximate reconstruction of continuous spatially complex domain motions by multialignment NMR residual dipolar couplings. The Journal of Physical Chemistry. B. 113: 6173-6. PMID 19358547 DOI: 10.1021/Jp900411Z  0.387
2009 Buhrlage SJ, Bates CA, Rowe SP, Minter AR, Brennan BB, Majmudar CY, Wemmer DE, Al-Hashimi H, Mapp AK. Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. Acs Chemical Biology. 4: 335-44. PMID 19348463 DOI: 10.1021/Cb900028J  0.302
2009 Hansen AL, Nikolova EN, Casiano-Negroni A, Al-Hashimi HM. Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. Journal of the American Chemical Society. 131: 3818-9. PMID 19243182 DOI: 10.1021/Ja8091399  0.8
2009 Frank AT, Stelzer A, Andricioaei I, Al-Hashimi H. An RNA Structural Ensemble Derived by Combining MD and Elongated NMR RDCs Provides Evidence for Adaptive Recognition via Conformational Selection Biophysical Journal. 96: 579a. DOI: 10.1016/J.Bpj.2008.12.3026  0.824
2009 Al-Hashimi H. Atomic Movies of RNA Dynamics Reveal Basis for Conformational Adaptation Biophysical Journal. 96: 373a. DOI: 10.1016/J.Bpj.2008.12.2806  0.486
2008 Fisher CK, Zhang Q, Stelzer A, Al-Hashimi HM. Ultrahigh resolution characterization of domain motions and correlations by multialignment and multireference residual dipolar coupling NMR. The Journal of Physical Chemistry. B. 112: 16815-22. PMID 19367865 DOI: 10.1021/Jp806188J  0.779
2008 Dethoff EA, Hansen AL, Musselman C, Watt ED, Andricioaei I, Al-Hashimi HM. Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. Biophysical Journal. 95: 3906-15. PMID 18621815 DOI: 10.1529/Biophysj.108.140285  0.825
2008 Al-Hashimi HM, Walter NG. RNA dynamics: it is about time. Current Opinion in Structural Biology. 18: 321-9. PMID 18547802 DOI: 10.1016/J.Sbi.2008.04.004  0.519
2008 Zhang Q, Al-Hashimi HM. Extending the NMR spatial resolution limit for RNA by motional couplings. Nature Methods. 5: 243-5. PMID 18246076 DOI: 10.1038/Nmeth.1180  0.467
2007 Zhang Q, Stelzer AC, Fisher CK, Al-Hashimi HM. Visualizing spatially correlated dynamics that directs RNA conformational transitions. Nature. 450: 1263-7. PMID 18097416 DOI: 10.1038/Nature06389  0.851
2007 Hansen AL, Al-Hashimi HM. Dynamics of large elongated RNA by NMR carbon relaxation. Journal of the American Chemical Society. 129: 16072-82. PMID 18047338 DOI: 10.1021/Ja0757982  0.692
2007 Al-Hashimi HM. Beyond static structures of RNA by NMR: folding, refolding, and dynamics at atomic resolution. Biopolymers. 86: 345-7. PMID 17597469 DOI: 10.1002/Bip.20754  0.494
2007 Getz M, Sun X, Casiano-Negroni A, Zhang Q, Al-Hashimi HM. NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. Biopolymers. 86: 384-402. PMID 17594140 DOI: 10.1002/Bip.20765  0.851
2007 Bailor MH, Musselman C, Hansen AL, Gulati K, Patel DJ, Al-Hashimi HM. Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings. Nature Protocols. 2: 1536-46. PMID 17571061 DOI: 10.1038/Nprot.2007.221  0.854
2007 Casiano-Negroni A, Sun X, Al-Hashimi HM. Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition. Biochemistry. 46: 6525-35. PMID 17488097 DOI: 10.1021/Bi700335N  0.623
2007 Musselman C, Al-Hashimi HM, Andricioaei I. iRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hinge. Biophysical Journal. 93: 411-22. PMID 17449677 DOI: 10.1529/Biophysj.107.104620  0.721
2007 Sun X, Zhang Q, Al-Hashimi HM. Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing-duplex structural transition. Nucleic Acids Research. 35: 1698-713. PMID 17311812 DOI: 10.1093/Nar/Gkm020  0.585
2007 Getz MM, Andrews AJ, Fierke CA, Al-Hashimi HM. Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. Rna (New York, N.Y.). 13: 251-66. PMID 17194721 DOI: 10.1261/Rna.264207  0.807
2006 Musselman C, Pitt SW, Gulati K, Foster LL, Andricioaei I, Al-Hashimi HM. Impact of static and dynamic A-form heterogeneity on the determination of RNA global structural dynamics using NMR residual dipolar couplings. Journal of Biomolecular Nmr. 36: 235-49. PMID 17077936 DOI: 10.1007/S10858-006-9087-9  0.759
2006 Zhang Q, Sun X, Watt ED, Al-Hashimi HM. Resolving the motional modes that code for RNA adaptation. Science (New York, N.Y.). 311: 653-6. PMID 16456078 DOI: 10.1126/Science.1119488  0.638
2006 Hansen AL, Al-Hashimi HM. Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 179: 299-307. PMID 16431143 DOI: 10.1016/J.Jmr.2005.12.012  0.648
2005 Al-Hashimi HM. Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy. Chembiochem : a European Journal of Chemical Biology. 6: 1506-19. PMID 16138302 DOI: 10.1002/cbic.200500002  0.449
2005 Pitt SW, Zhang Q, Patel DJ, Al-Hashimi HM. Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. Angewandte Chemie (International Ed. in English). 44: 3412-5. PMID 15861447 DOI: 10.1002/Anie.200500075  0.602
2005 Al-Hashimi HM. Cover Picture: Dynamics-Based Amplification of RNA Function and Its Characterization by Using NMR Spectroscopy (ChemBioChem 9/2005) Chembiochem. 6: 1472-1473. DOI: 10.1002/cbic.200590028  0.418
2004 Pitt SW, Majumdar A, Serganov A, Patel DJ, Al-Hashimi HM. Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization. Journal of Molecular Biology. 338: 7-16. PMID 15050819 DOI: 10.1016/J.Jmb.2004.02.031  0.606
2003 Zhang Q, Throolin R, Pitt SW, Serganov A, Al-Hashimi HM. Probing motions between equivalent RNA domains using magnetic field induced residual dipolar couplings: accounting for correlations between motions and alignment. Journal of the American Chemical Society. 125: 10530-1. PMID 12940730 DOI: 10.1021/Ja0363056  0.369
2003 Al-Hashimi HM, Pitt SW, Majumdar A, Xu W, Patel DJ. Mg2+-induced variations in the conformation and dynamics of HIV-1 TAR RNA probed using NMR residual dipolar couplings. Journal of Molecular Biology. 329: 867-73. PMID 12798678 DOI: 10.1016/S0022-2836(03)00517-5  0.571
2003 TOLMAN JR, AL-HASHIMI HM. NMR Studies of Biomolecular Dynamics and Structural Plasticity Using Residual Dipolar Couplings Annual Reports On Nmr Spectroscopy. 51: 105-166. DOI: 10.1016/S0066-4103(03)51003-1  0.74
2002 Al-Hashimi HM, Gorin A, Majumdar A, Gosser Y, Patel DJ. Towards structural genomics of RNA: rapid NMR resonance assignment and simultaneous RNA tertiary structure determination using residual dipolar couplings. Journal of Molecular Biology. 318: 637-49. PMID 12054812 DOI: 10.1016/S0022-2836(02)00160-2  0.656
2002 Al-Hashimi HM, Patel DJ. Residual dipolar couplings: synergy between NMR and structural genomics. Journal of Biomolecular Nmr. 22: 1-8. PMID 11885976 DOI: 10.1023/A:1013801714041  0.524
2002 Al-Hashimi HM, Gosser Y, Gorin A, Hu W, Majumdar A, Patel DJ. Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. Journal of Molecular Biology. 315: 95-102. PMID 11779230 DOI: 10.1006/Jmbi.2001.5235  0.67
2001 Al-Hashimi HM, Gorin A, Majumdar A, Patel DJ. Alignment of the HTLV-I Rex peptide bound to its target RNA aptamer from magnetic field-induced residual dipolar couplings and intermolecular hydrogen bonds. Journal of the American Chemical Society. 123: 3179-80. PMID 11457047 DOI: 10.1021/Ja004133W  0.532
2001 Tolman JR, Al-Hashimi HM, Kay LE, Prestegard JH. Structural and dynamic analysis of residual dipolar coupling data for proteins. Journal of the American Chemical Society. 123: 1416-24. PMID 11456715 DOI: 10.1021/Ja002500Y  0.793
2001 Al-Hashimi HM, Majumdar A, Gorin A, Kettani A, Skripkin E, Patel DJ. Field- and phage-induced dipolar couplings in a homodimeric DNA quadruplex: relative orientation of G.(C-A) triad and G-tetrad motifs and direct determination of C2 symmetry axis orientation. Journal of the American Chemical Society. 123: 633-40. PMID 11456575 DOI: 10.1021/Ja003379Y  0.487
2001 Tian F, Al-Hashimi HM, Craighead JL, Prestegard JH. Conformational analysis of a flexible oligosaccharide using residual dipolar couplings. Journal of the American Chemical Society. 123: 485-92. PMID 11456551 DOI: 10.1021/ja002900l  0.461
2001 Al-Hashimi HM, Tolman JR, Majumdar A, Gorin A, Patel DJ. Determining stoichiometry in homomultimeric nucleic acid complexes using magnetic field induced residual dipolar couplings. Journal of the American Chemical Society. 123: 5806-7. PMID 11403617 DOI: 10.1021/Ja0105865  0.718
2000 Prestegard JH, al-Hashimi HM, Tolman JR. NMR structures of biomolecules using field oriented media and residual dipolar couplings. Quarterly Reviews of Biophysics. 33: 371-424. PMID 11233409 DOI: 10.1017/S0033583500003656  0.765
2000 Fowler CA, Tian F, Al-Hashimi HM, Prestegard JH. Rapid determination of protein folds using residual dipolar couplings. Journal of Molecular Biology. 304: 447-60. PMID 11090286 DOI: 10.1006/Jmbi.2000.4199  0.693
2000 Al-Hashimi HM, Valafar H, Terrell M, Zartler ER, Eidsness MK, Prestegard JH. Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 143: 402-6. PMID 10729267 DOI: 10.1006/Jmre.2000.2049  0.551
2000 Al-Hashimi HM, Bolon PJ, Prestegard JH. Molecular symmetry as an aid to geometry determination in ligand protein complexes. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 142: 153-8. PMID 10617446 DOI: 10.1006/Jmre.1999.1937  0.541
1999 Bolon PJ, Al-Hashimi HM, Prestegard JH. Residual dipolar coupling derived orientational constraints on ligand geometry in a 53 kDa protein-ligand complex. Journal of Molecular Biology. 293: 107-15. PMID 10512719 DOI: 10.1006/Jmbi.1999.3133  0.507
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