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Herbert Waldmann, Ph.D. - Publications

Affiliations: 
Chemical Biology Max Planck Institute of Molecular Physiology 
Area:
Chemical Biology
Website:
http://www.mpi-dortmund.mpg.de/english/ueberInstitut/Struktur/Direktoren/Waldmann/index.html
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Year Citation  Score
2023 Corkery D, Ursu A, Lucas B, Grigalunas M, Kriegler S, Oliva R, Dec R, Koska S, Pahl A, Sievers S, Ziegler S, Winter R, Wu YW, Waldmann H. Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair. Chembiochem : a European Journal of Chemical Biology. e202300579. PMID 37869939 DOI: 10.1002/cbic.202300579  0.396
2023 Xie J, Pahl A, Krzyzanowski A, Krupp A, Liu J, Koska S, Schölermann B, Zhang R, Bonowski J, Sievers S, Strohmann C, Ziegler S, Grigalunas M, Waldmann H. Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space. Angewandte Chemie (International Ed. in English). e202310222. PMID 37818743 DOI: 10.1002/anie.202310222  0.351
2023 Aoyama H, Davies C, Liu J, Pahl A, Kirchhoff JL, Scheel R, Sievers S, Strohmann C, Grigalunas M, Waldmann H. Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds. Chemistry (Weinheim An Der Bergstrasse, Germany). e202303027. PMID 37755456 DOI: 10.1002/chem.202303027  0.385
2023 Liu J, Zhang R, Mallick S, Patil S, Wientjens C, Flegel J, Krupp A, Strohmann C, Grassin C, Merten C, Pahl A, Grigalunas M, Waldmann H. A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science. 14: 7936-7943. PMID 37502335 DOI: 10.1039/d3sc01240a  0.428
2023 Liu J, Mallick S, Xie Y, Grassin C, Lucas B, Schölermann B, Pahl A, Scheel R, Strohmann C, Protzel C, Berg T, Merten C, Ziegler S, Waldmann H. Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles. Angewandte Chemie (International Ed. in English). e202301955. PMID 36929571 DOI: 10.1002/anie.202301955  0.428
2022 Young RJ, Flitsch SL, Grigalunas M, Leeson PD, Quinn RJ, Turner NJ, Waldmann H. The Time and Place for Nature in Drug Discovery. Jacs Au. 2: 2400-2416. PMID 36465532 DOI: 10.1021/jacsau.2c00415  0.51
2022 Flegel J, Shaaban S, Jia ZJ, Schulte B, Lian Y, Krzyzanowski A, Metz M, Schneidewind T, Wesseler F, Flegel A, Reich A, Brause A, Xue G, Zhang M, Dötsch L, ... ... Waldmann H, et al. The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. Journal of Medicinal Chemistry. PMID 36459434 DOI: 10.1021/acs.jmedchem.2c00956  0.713
2022 Krzyzanowski A, Esser LM, Willaume A, Prudent R, Peter C, 't Hart P, Waldmann H. Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors. Journal of Medicinal Chemistry. PMID 36378254 DOI: 10.1021/acs.jmedchem.2c01273  0.764
2022 Waldmann H, Akbarzadeh M, Flegel J, Patil S, Shang E, Narayan R, Buchholzer M, Jasemi NSK, Grigalunas M, Krzyzanowski A, Abegg D, Shuster A, Potowski M, Karatas H, Karageorgis G, et al. The Pseudo-Natural Product Rhonin Targets RHOGDI. Angewandte Chemie (International Ed. in English). PMID 35170181 DOI: 10.1002/anie.202115193  0.79
2022 Wesseler F, Riege D, Puthanveedu M, Halver J, Müller E, Bertrand J, Antonchick AP, Sievers S, Waldmann H, Schade D. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. Journal of Medicinal Chemistry. PMID 35108017 DOI: 10.1021/acs.jmedchem.1c01800  0.697
2021 Burhop A, Bag S, Grigalunas M, Woitalla S, Bodenbinder P, Brieger L, Strohmann C, Pahl A, Sievers S, Waldmann H. Synthesis of Indofulvin Pseudo-Natural Products Yields a New Autophagy Inhibitor Chemotype. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2102042. PMID 34346568 DOI: 10.1002/advs.202102042  0.749
2021 Waldmann H, Liu J, Flegel J, Otte F, Pahl A, Sievers S, Strohmann C. Combination of pseudo-natural product design and formal natural product ring distortion yields stereochemically and biologically diverse pseudo-sesquiterpenoid alkaloids. Angewandte Chemie (International Ed. in English). PMID 34297473 DOI: 10.1002/anie.202106654  0.406
2021 Waldmann H, Yildirim O, Grigalunas M, Brieger L, Strohmann C, Antonchick AP. Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. Angewandte Chemie (International Ed. in English). PMID 34236754 DOI: 10.1002/anie.202108072  0.699
2021 Grigalunas M, Burhop A, Zinken S, Pahl A, Gally JM, Wild N, Mantel Y, Sievers S, Foley DJ, Scheel R, Strohmann C, Antonchick AP, Waldmann H. Natural product fragment combination to performance-diverse pseudo-natural products. Nature Communications. 12: 1883. PMID 33767198 DOI: 10.1038/s41467-021-22174-4  0.694
2020 Waldmann H, Liu J, Cremosnik GS, Otte F, Pahl A, Sievers S, Strohmann C. Design, synthesis and biological evaluation of chemically and biologically diverse pyrroquinoline pseudo natural products. Angewandte Chemie (International Ed. in English). PMID 33200868 DOI: 10.1002/anie.202013731  0.334
2020 Shaaban S, Li H, Otte F, Strohmann C, Antonchick AP, Waldmann H. Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex. Organic Letters. PMID 33186042 DOI: 10.1021/acs.orglett.0c03355  0.71
2020 Cremosnik GS, Liu J, Waldmann H. Guided by evolution: from biology oriented synthesis to pseudo natural products. Natural Product Reports. PMID 33020792 DOI: 10.1039/d0np00015a  0.333
2020 Karatas H, Akbarzadeh M, Adihou H, Hahne G, Pobbati AV, Yihui Ng E, Guéret SM, Sievers S, Pahl A, Metz M, Zinken S, Dötsch L, Nowak C, Thavam S, Friese A, ... ... Waldmann H, et al. Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain (TEAD) Central Pocket. Journal of Medicinal Chemistry. PMID 32907324 DOI: 10.1021/Acs.Jmedchem.0C01275  0.33
2020 Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H. Discovery of small-molecule modulator of heterotrimeric G-protein by integrated phenotypic profiling and chemical proteomics. Bioscience, Biotechnology, and Biochemistry. 1-7. PMID 32867616 DOI: 10.1080/09168451.2020.1812375  0.334
2020 Waldmann H, Shaaban S, Davies C, Merten C, Flegel J, Otte F, Strohmann C. Rh(III)-catalyzed C-H Activation of Aryl-Hydroxamates for the Synthesis of Isoindolinones. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32428319 DOI: 10.1002/Chem.202002384  0.367
2020 Waldmann H, Foley DJ, Zinken S, Corkery D, Laraia L, Pahl A, Wu Y. Phenotyping reveals the targets of a pseudo-natural product autophagy inhibitor. Angewandte Chemie (International Ed. in English). PMID 32108411 DOI: 10.1002/Anie.202000364  0.381
2020 Guéret SM, Thavam S, Carbajo RJ, Potowski M, Larsson N, Dahl G, Dells Eacute N A, Grossmann TN, Plowright AT, Valeur E, Lemurell M, Waldmann H. Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. Journal of the American Chemical Society. PMID 32058716 DOI: 10.1021/Jacs.0C00269  0.348
2020 Karageorgis G, Foley DJ, Laraia L, Waldmann H. Principle and design of pseudo-natural products. Nature Chemistry. PMID 32015480 DOI: 10.1038/S41557-019-0411-X  0.336
2019 Waldmann H, Winzker M, Friese A, Koch U, Janning P, Ziegler S. Development of a PDEδ targeting PROTAC that impairs lipid metabolism. Angewandte Chemie (International Ed. in English). PMID 31829492 DOI: 10.1002/Anie.201913904  0.346
2019 Waldmann H, Laraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, et al. Image-based morphological profiling identifies a lysosomotropic, iron-sequestering autophagy inhibitor. Angewandte Chemie (International Ed. in English). PMID 31769920 DOI: 10.1002/Anie.201913712  0.785
2019 Pobbati AV, Mejuch T, Chakraborty S, Karatas H, Bharath SR, Guéret SM, Goy PA, Hahne G, Pahl A, Sievers S, Guccione E, Song H, Waldmann H, Hong W. Identification of Quinolinols as Activators of TEAD-dependent Transcription. Acs Chemical Biology. PMID 31742995 DOI: 10.1021/Acschembio.9B00786  0.304
2019 Cromm PM, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN. Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119. Chembiochem : a European Journal of Chemical Biology. PMID 31680402 DOI: 10.1002/Cbic.201900615  0.657
2019 Waldmann H, Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales M, Wilke J, Laraia L, Tschapalda K, Metz M, et al. Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3. Angewandte Chemie (International Ed. in English). PMID 31469221 DOI: 10.1002/Anie.201909518  0.305
2019 Waldmann H, Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angewandte Chemie (International Ed. in English). PMID 31454140 DOI: 10.1002/Anie.201907632  0.312
2019 Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M. Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. Acs Chemical Biology. PMID 31436407 DOI: 10.1021/Acschembio.9B00444  0.327
2019 Waldmann H, Christoforow A, Wilke J, Binici A, Pahl A, Ostermann C, Sievers S. Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products. Angewandte Chemie (International Ed. in English). PMID 31339620 DOI: 10.1002/Anie.201907853  0.302
2019 Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, ... ... Waldmann H, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nature Chemical Biology. PMID 31222192 DOI: 10.1038/S41589-019-0307-5  0.501
2019 Waldmann H, Friese A, Kapoor S, Schneidewind T, Vidadala SR, Sardana J, Brause A, Förster T, Bischoff M, Wagner J, Janning P, Ziegler S. Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling. Angewandte Chemie (International Ed. in English). PMID 31173446 DOI: 10.1002/Anie.201905977  0.642
2019 Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens PIH, Waldmann H. Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells. Cell Chemical Biology. PMID 30956149 DOI: 10.1016/J.Chembiol.2019.02.019  0.792
2019 Reckzeh ES, Brockmeyer A, Metz M, Waldmann H, Janning P. Target Engagement of Small Molecules: Thermal Profiling Approaches on Different Levels. Methods in Molecular Biology (Clifton, N.J.). 1888: 73-98. PMID 30519941 DOI: 10.1007/978-1-4939-8891-4_4  0.302
2019 ‘T Hart P, Openy J, Krzyzanowski A, Adihou H, Waldmann H. Hot-spot guided design of macrocyclic inhibitors of the LSD1-CoREST1 interaction Tetrahedron. 75: 130685. DOI: 10.1016/J.Tet.2019.130685  0.327
2019 Cromm PM, Adihou H, Kapoor S, Vazquez‐Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN. Cover Feature: Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 (ChemBioChem 24/2019) Chembiochem. 20: 2971-2971. DOI: 10.1002/Cbic.201900704  0.647
2018 Schneidewind T, Kapoor S, Garivet G, Karageorgis G, Narayan R, Vendrell-Navarro G, Antonchick AP, Ziegler S, Waldmann H. The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype. Cell Chemical Biology. PMID 30686759 DOI: 10.1016/J.Chembiol.2018.11.014  0.778
2018 Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schroeder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, et al. Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angewandte Chemie (International Ed. in English). PMID 30569600 DOI: 10.1002/anie.201810312  0.334
2018 Li H, Gontla R, Flegel J, Merten C, Ziegler S, Antonchick AP, Waldmann H. Enantioselective Formal C(sp )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angewandte Chemie (International Ed. in English). PMID 30511449 DOI: 10.1002/Anie.201811041  0.73
2018 Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, ... ... Waldmann H, et al. Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways. Cell Chemical Biology. 25: 1095-1106.e23. PMID 30251630 DOI: 10.1016/J.Chembiol.2018.05.016  0.647
2018 Waldmann H, Shan G, Flegel J, Li H, Merten C, Ziegler S, Antonchick AP. C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors. Angewandte Chemie (International Ed. in English). PMID 30203905 DOI: 10.1002/Anie.201809680  0.735
2018 Karageorgis G, Reckzeh ES, Ceballos J, Schwalfenberg M, Sievers S, Ostermann C, Pahl A, Ziegler S, Waldmann H. Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3. Nature Chemistry. PMID 30202104 DOI: 10.1038/S41557-018-0132-6  0.304
2018 Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H. Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions. Chembiochem : a European Journal of Chemical Biology. PMID 30129686 DOI: 10.1002/Cbic.201800406  0.348
2018 Winter RHA, Erwin N, Dwivedi M, Mejuch T, Waldmann H. UNC119A decreases the membrane-binding of myristoylated c-Src. Chembiochem : a European Journal of Chemical Biology. PMID 29700916 DOI: 10.1002/Cbic.201800158  0.503
2018 Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H. Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity. The Journal of Organic Chemistry. PMID 29460633 DOI: 10.1021/Acs.Joc.7B03202  0.734
2018 Waldmann H, Jia ZJ, Shan G, Daniliuc CG, Antonchick AP. Enantioselective Synthesis of the Spiro-Tropanyl Oxindole Scaffold Through Bimetallic Relay Catalysis. Angewandte Chemie (International Ed. in English). PMID 29419912 DOI: 10.1002/Anie.201712882  0.733
2018 Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, ... ... Waldmann H, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chemical Biology. PMID 29396292 DOI: 10.1016/J.Chembiol.2017.12.014  0.314
2018 Karageorgis G, Waldmann H. Guided by Evolution: Biology-Oriented Synthesis of Bioactive Compound Classes Synthesis. 51: 55-66. DOI: 10.1055/S-0037-1610368  0.394
2018 Robke L, Rodrigues T, Schröder P, Foley DJ, Bernardes GJ, Laraia L, Waldmann H. Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors Tetrahedron. 74: 4531-4537. DOI: 10.1016/J.Tet.2018.07.021  0.338
2018 Laraia L, Robke L, Waldmann H. Bioactive Compound Collections: From Design to Target Identification Chem. 4: 705-730. DOI: 10.1016/J.Chempr.2018.01.012  0.332
2018 Lee Y, Knauer L, Louven K, Golz C, Strohmann C, Waldmann H, Kumar K. Gold(I)-Catalyzed and Nucleophile-Guided Ligand-Directed Divergent Synthesis European Journal of Organic Chemistry. 2018: 5688-5699. DOI: 10.1002/Ejoc.201801080  0.308
2017 Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, ... ... Waldmann H, et al. Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chemical Biology. PMID 29307839 DOI: 10.1016/J.Chembiol.2017.12.007  0.333
2017 Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ. Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells. Scientific Reports. 7: 16988. PMID 29209034 DOI: 10.1038/S41598-017-17303-3  0.646
2017 Waldmann H, Lee YC, Kumar K. Ligand-directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems. Angewandte Chemie (International Ed. in English). PMID 29105306 DOI: 10.1002/Anie.201710247  0.357
2017 Pahl A, Waldmann H, Kumar K. Exploring Natural Product Fragments for Drug and Probe Discovery. Chimia. 71: 653-660. PMID 29070410 DOI: 10.2533/Chimia.2017.653  0.333
2017 Küchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S. Identification of novel PDEδ interacting proteins. Bioorganic & Medicinal Chemistry. PMID 28935183 DOI: 10.1016/J.Bmc.2017.08.033  0.324
2017 Waldmann H, Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HJ, Sterneckert J, Ziegler S, Schneider G. Discovery of a Novel Hedgehog Signaling Pathway Inhibitor by Cell-based Compound Discovery and Target Prediction. Angewandte Chemie (International Ed. in English). PMID 28833911 DOI: 10.1002/Anie.201707394  0.337
2017 Waldmann H, Xu H, Laraia L, Schneider L, Louven K, Strohmann C, Antonchick AP. Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Novel Autophagy Inhibitor Class. Angewandte Chemie (International Ed. in English). PMID 28696533 DOI: 10.1002/Anie.201706005  0.752
2017 Waldmann H, Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S. Natural Product Withanolide-Inspired Small molecules as Potent Inhibitors of Wnt Signaling. Chembiochem : a European Journal of Chemical Biology. PMID 28678390 DOI: 10.1002/Cbic.201700260  0.66
2017 Winter RHA, Dwiwedi M, Mejuch T, Waldmann H. The Myristoyl Modification of c-Src Alters the Lateral Organization of Host Heterogenous Raft-like Membranes. Angewandte Chemie (International Ed. in English). PMID 28657213 DOI: 10.1002/Anie.201706233  0.479
2017 Laraia L, Waldmann H. Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification. Drug Discovery Today. Technologies. 23: 75-82. PMID 28647090 DOI: 10.1016/J.Ddtec.2017.03.003  0.358
2017 Waldmann H, Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Wu Y, Engel J. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angewandte Chemie (International Ed. in English). PMID 28544137 DOI: 10.1002/Anie.201703738  0.319
2017 Mejuch T, Garivet G, Hofer W, Kaiser N, Fansa EK, Ehrt C, Koch O, Baumann M, Ziegler S, Wittinghofer A, Waldmann H. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angewandte Chemie (International Ed. in English). PMID 28471079 DOI: 10.1002/Anie.201701905  0.794
2017 Martín-Gago P, Fansa EK, Winzker M, Murarka S, Janning P, Schultz-Fademrecht C, Baumann M, Wittinghofer A, Waldmann H. Covalent Protein Labeling at Glutamic Acids. Cell Chemical Biology. PMID 28434875 DOI: 10.1016/J.Chembiol.2017.03.015  0.798
2017 Waldmann H, Förster T, Lopéz-Tosco S, Ziegler S, Antonchick AP. Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity. Chembiochem : a European Journal of Chemical Biology. PMID 28421720 DOI: 10.1002/Cbic.201700015  0.74
2017 Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, ... Waldmann H, et al. Picomolar, selective and subtype specific small-molecule inhibition of TRPC1/4/5 channels. The Journal of Biological Chemistry. PMID 28325835 DOI: 10.1074/Jbc.M116.773556  0.653
2017 Waldmann H, Martinez NE, Zimmermann TJ, Goosmann C, Alexander T, Hedberg C, Ziegler S, Zychlinsky A. Tetrahydroisoquinolines are Novel Inhibitors of Neutrophil Extracellular Trap (NET) Formation. Chembiochem : a European Journal of Chemical Biology. PMID 28240414 DOI: 10.1002/Cbic.201600650  0.325
2017 Lee YC, Patil S, Golz C, Strohmann C, Ziegler S, Kumar K, Waldmann H. A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity. Nature Communications. 8: 14043. PMID 28195128 DOI: 10.1038/Ncomms14043  0.345
2017 Waldmann H, Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Grossmann TN, Plowright AT. New Modalities for Challenging Targets in Drug Discovery. Angewandte Chemie (International Ed. in English). PMID 28186380 DOI: 10.1002/Anie.201611914  0.355
2017 Jia ZJ, Merten C, Gontla R, Daniliuc CG, Antonchick AP, Waldmann H. General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angewandte Chemie (International Ed. in English). PMID 28124831 DOI: 10.1002/Anie.201611981  0.709
2017 Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H. A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie (International Ed. in English). PMID 28106325 DOI: 10.1002/Anie.201610957  0.787
2017 Laraia L, Ohsawa K, Konstantinidis G, Robke L, Wu YW, Kumar K, Waldmann H. Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors. Angewandte Chemie (International Ed. in English). PMID 28097798 DOI: 10.1002/Anie.201611670  0.39
2017 Jia Z, Merten C, Knauer L, Murarka S, Strohmann C, Waldmann H. Biology-Oriented Synthesis of Decahydro-4,8-epoxyazulene Scaffolds Synlett. 28: 2918-2922. DOI: 10.1055/S-0036-1588558  0.721
2016 Martín-Gago P, Fansa EK, Wittinghofer A, Waldmann H. Structure-based development of PDEδ inhibitors. Biological Chemistry. PMID 27935847 DOI: 10.1515/Hsz-2016-0272  0.777
2016 Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa E, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H. Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27809361 DOI: 10.1002/Chem.201603222  0.782
2016 Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A. Novel biochemical and structural insights into the interaction of myristoylated cargo with Unc119 and their release by Arl2/3. The Journal of Biological Chemistry. PMID 27481943 DOI: 10.1074/Jbc.M116.741827  0.319
2016 Mejuch T, Waldmann H. Synthesis of Lipidated Proteins. Bioconjugate Chemistry. PMID 27444727 DOI: 10.1021/Acs.Bioconjchem.6B00261  0.339
2016 Tschapalda K, Zhang YQ, Liu L, Golovnina K, Schlemper T, Eichmann TO, Lal-Nag M, Sreenivasan U, McLenithan J, Ziegler S, Sztalryd C, Lass A, Auld D, Oliver B, Waldmann H, et al. A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics. Ebiomedicine. 8: 49-59. PMID 27428418 DOI: 10.1016/J.Ebiom.2016.04.014  0.321
2016 Sperlich B, Kapoor S, Waldmann H, Winter R, Weise K. Regulation of K-Ras4B Membrane Binding by Calmodulin. Biophysical Journal. 111: 113-22. PMID 27410739 DOI: 10.1016/J.Bpj.2016.05.042  0.685
2016 Schroeder P, Bauer JO, Strohmann C, Kumar K, Waldmann H. Synthesis of an Iridoid-Inspired Compound Collection and the Discovery of Autophagy Inhibitors. The Journal of Organic Chemistry. PMID 27352173 DOI: 10.1021/Acs.Joc.6B01185  0.386
2016 Cromm PM, Spiegel J, Kuechler P, Dietrich L, Kriegesmann J, Wendt M, Goody R, Waldmann H, Grossmann TN. Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase. Acs Chemical Biology. PMID 27336832 DOI: 10.1021/Acschembio.6B00386  0.355
2016 Kapoor S, Waldmann H, Ziegler S. Novel approaches to map small molecule-target interactions. Bioorganic & Medicinal Chemistry. PMID 27240466 DOI: 10.1016/J.Bmc.2016.05.020  0.659
2016 Kötzner L, Leutzsch M, Sievers S, Patil S, Waldmann H, Zheng Y, Thiel W, List B. The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway. Angewandte Chemie (International Ed. in English). PMID 27239757 DOI: 10.1002/Anie.201602932  0.307
2016 Xu H, Golz C, Strohmann C, Antonchick AP, Waldmann H. Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition. Angewandte Chemie (International Ed. in English). PMID 27193834 DOI: 10.1002/Anie.201602084  0.732
2016 Qian Y, Schürmann M, Janning P, Hedberg C, Waldmann H. Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity. Angewandte Chemie (International Ed. in English). PMID 27159346 DOI: 10.1002/Anie.201602666  0.338
2016 Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, ... Waldmann H, et al. Identification of pyrazolopyridazinones as PDEδ inhibitors. Nature Communications. 7: 11360. PMID 27094677 DOI: 10.1038/Ncomms11360  0.794
2016 Cromm PM, Schaubach S, Spiegel J, Fürstner A, Grossmann TN, Waldmann H. Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides. Nature Communications. 7: 11300. PMID 27075966 DOI: 10.1038/Ncomms11300  0.527
2016 Erwin N, Sperlich B, Garivet G, Waldmann H, Weise K, Winter R. Lipoprotein insertion into membranes of various complexity: lipid sorting, interfacial adsorption and protein clustering. Physical Chemistry Chemical Physics : Pccp. PMID 26960984 DOI: 10.1039/C6Cp00563B  0.784
2016 Kumar K, Dakas P, Waldmann H. Natural Product Inspired Enantioselective Synthesis of Hexahydro-aza-pentalenones Heterocycles. 93: 465. DOI: 10.3987/Com-15-S(T)61  0.334
2016 Baumann M, Höing S, Yeh T, Martinez N, Habenberger P, Kremer L, Drexler HC, Küchler P, Reinhardt P, Choidas A, Zischinsky M, Zischinsky G, Ketcham SA, Wagner L, Nussbaumer P, ... ... Waldmann H, et al. Abstract 2997: Dynarrestin, a novel dynein inhibitor that does not block ciliogenesis Cancer Research. 76: 2997-2997. DOI: 10.1158/1538-7445.Am2016-2997  0.34
2016 Antonchick A, Waldmann H, Murarka S, Golz C, Strohmann C. Biology-Oriented Synthesis of 3,3-Spiro(2-tetrahydrofuranyl)oxindoles Synthesis. 49: 87-95. DOI: 10.1055/S-0035-1561665  0.794
2016 Pérez-Galán P, Waldmann H, Kumar K. Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes Tetrahedron. DOI: 10.1016/J.Tet.2016.03.020  0.326
2015 Sellstedt M, Schwalfenberg M, Ziegler S, Antonchick AP, Waldmann H. Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection. Organic & Biomolecular Chemistry. PMID 26606903 DOI: 10.1039/C5Ob02272J  0.709
2015 Pahl A, Lakemeyer M, Vielberg MT, Hackl MW, Vomacka J, Korotkov VS, Stein ML, Fetzer C, Lorenz-Baath K, Richter K, Waldmann H, Groll M, Sieber SA. Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association. Angewandte Chemie (International Ed. in English). PMID 26566002 DOI: 10.1002/Anie.201507266  0.328
2015 Mejuch T, van Hattum H, Triola G, Jaiswal M, Waldmann H. Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins. Chembiochem : a European Journal of Chemical Biology. PMID 26503308 DOI: 10.1002/Cbic.201500355  0.304
2015 Cromm PM, Spiegel J, Grossmann TN, Waldmann H. Direct Modulation of Small GTPase Activity and Function. Angewandte Chemie (International Ed. in English). 54: 13516-37. PMID 26470842 DOI: 10.1002/Anie.201504357  0.348
2015 Meiß R, Kumar K, Waldmann H. Divergent Gold(I)-Catalyzed Skeletal Rearrangements of 1,7-Enynes. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 13526-30. PMID 26356499 DOI: 10.1002/Chem.201502843  0.327
2015 Ursu A, Waldmann H. Hide and seek: Identification and confirmation of small molecule protein targets. Bioorganic & Medicinal Chemistry Letters. PMID 26115575 DOI: 10.1016/J.Bmcl.2015.06.023  0.329
2015 Hackl MW, Lakemeyer M, Dahmen M, Glaser M, Pahl A, Lorenz-Baath K, Menzel T, Sievers S, Böttcher T, Antes I, Waldmann H, Sieber SA. Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization. Journal of the American Chemical Society. PMID 26083639 DOI: 10.1021/Jacs.5B03084  0.368
2015 Vendrell-Navarro G, Rúa F, Bujons J, Brockmeyer A, Janning P, Ziegler S, Messeguer A, Waldmann H. Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin. Chembiochem : a European Journal of Chemical Biology. PMID 26010161 DOI: 10.1002/Cbic.201500169  0.351
2015 Murarka S, Jia ZJ, Merten C, Daniliuc CG, Antonchick AP, Waldmann H. Rhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids. Angewandte Chemie (International Ed. in English). 54: 7653-6. PMID 25959033 DOI: 10.1002/Anie.201502233  0.794
2015 Schröder P, Förster T, Kleine S, Becker C, Richters A, Ziegler S, Rauh D, Kumar K, Waldmann H. Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4. Angewandte Chemie (International Ed. in English). PMID 25908259 DOI: 10.1002/Anie.201501515  0.326
2015 Danda A, Kumar K, Waldmann H. A general catalytic reaction sequence to access alkaloid-inspired indole polycycles. Chemical Communications (Cambridge, England). 51: 7536-9. PMID 25846800 DOI: 10.1039/C5Cc01555C  0.314
2015 Potowski M, Golz C, Strohmann C, Antonchick AP, Waldmann H. Biology-oriented synthesis of benzopyrano[3,4-c]pyrrolidines. Bioorganic & Medicinal Chemistry. 23: 2895-903. PMID 25792140 DOI: 10.1016/J.Bmc.2015.02.044  0.737
2015 Švenda J, Sheremet M, Kremer L, Maier L, Bauer JO, Strohmann C, Ziegler S, Kumar K, Waldmann H. Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling. Angewandte Chemie (International Ed. in English). 54: 5596-602. PMID 25736574 DOI: 10.1002/Anie.201500112  0.392
2015 Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S, Dehmelt L, Waldmann H. Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 5311-6. PMID 25694199 DOI: 10.1002/Chem.201500368  0.359
2015 Potowski M, Merten C, Antonchick AP, Waldmann H. Catalytic aerobic oxidation and tandem enantioselective cycloaddition in cascade multicomponent synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 4913-7. PMID 25676025 DOI: 10.1002/Chem.201500125  0.726
2015 Sankar MG, Mantilli L, Bull J, Giordanetto F, Bauer JO, Strohmann C, Waldmann H, Kumar K. Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library. Bioorganic & Medicinal Chemistry. 23: 2614-20. PMID 25648684 DOI: 10.1016/J.Bmc.2015.01.019  0.392
2015 Vendrell-Navarro G, Brockmeyer A, Waldmann H, Janning P, Ziegler S. Identification of the targets of biologically active small molecules using quantitative proteomics. Methods in Molecular Biology (Clifton, N.J.). 1263: 263-86. PMID 25618352 DOI: 10.1007/978-1-4939-2269-7_21  0.341
2015 Jia ZJ, Daniliuc CG, Antonchick AP, Waldmann H. Phosphine-catalyzed dearomatizing [3+2] annulations of isoquinolinium methylides with allenes. Chemical Communications (Cambridge, England). 51: 1054-7. PMID 25434405 DOI: 10.1039/C4Cc08555H  0.713
2015 Vidadala SR, Golz C, Strohmann C, Daniliuc CG, Waldmann H. Highly enantioselective intramolecular 1,3-dipolar cycloaddition: a route to piperidino-pyrrolizidines. Angewandte Chemie (International Ed. in English). 54: 651-5. PMID 25393926 DOI: 10.1002/Anie.201409942  0.36
2015 Vidadala SR, Waldmann H. One-pot synthesis of a natural product inspired pyrrolocoumarine compound collection by means of an intramolecular 1,3-dipolar cycloaddition as key step Tetrahedron Letters. 56: 3358-3360. DOI: 10.1016/J.Tetlet.2015.01.021  0.378
2014 Eschenbrenner-Lux V, Kumar K, Waldmann H. The asymmetric hetero-Diels-Alder reaction in the syntheses of biologically relevant compounds. Angewandte Chemie (International Ed. in English). 53: 11146-57. PMID 25220929 DOI: 10.1002/Anie.201404094  0.366
2014 van Hattum H, Waldmann H. Biology-oriented synthesis: harnessing the power of evolution. Journal of the American Chemical Society. 136: 11853-9. PMID 25074019 DOI: 10.1021/Ja505861D  0.392
2014 Kolundži? F, Murali A, Pérez-Galán P, Bauer JO, Strohmann C, Kumar K, Waldmann H. A cyclization-rearrangement cascade for the synthesis of structurally complex chiral gold(I)-aminocarbene complexes. Angewandte Chemie (International Ed. in English). 53: 8122-6. PMID 25044294 DOI: 10.1002/Anie.201403651  0.343
2014 Basu S, Waldmann H. Polymer supported synthesis of a natural product-inspired oxepane library. Bioorganic & Medicinal Chemistry. 22: 4430-44. PMID 24947480 DOI: 10.1016/J.Bmc.2014.05.039  0.687
2014 Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. Journal of Medicinal Chemistry. 57: 5435-48. PMID 24884780 DOI: 10.1021/Jm500632S  0.697
2014 Narayan R, Potowski M, Jia ZJ, Antonchick AP, Waldmann H. Catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis. Accounts of Chemical Research. 47: 1296-310. PMID 24730692 DOI: 10.1021/Ar400286B  0.808
2014 Bruss H, Schuster H, Martinez R, Kaiser M, Antonchick AP, Waldmann H. Synthesis of the B-seco limonoid core scaffold. Beilstein Journal of Organic Chemistry. 10: 194-208. PMID 24605139 DOI: 10.3762/Bjoc.10.15  0.711
2014 Rizzo S, Waldmann H. Development of a natural-product-derived chemical toolbox for modulation of protein function. Chemical Reviews. 114: 4621-39. PMID 24568160 DOI: 10.1021/Cr400442V  0.329
2014 Tran TT, Gerding-Reimers C, Schölermann B, Stanitzki B, Henkel T, Waldmann H, Ziegler S. Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species. Bioorganic & Medicinal Chemistry. 22: 5110-6. PMID 24530033 DOI: 10.1016/J.Bmc.2014.01.039  0.339
2014 Vogel A, Nikolaus J, Weise K, Triola G, Waldmann H, Winter R, Herrmann A, Huster D. Interaction of the human N-Ras protein with lipid raft model membranes of varying degrees of complexity. Biological Chemistry. 395: 779-89. PMID 24526608 DOI: 10.1515/Hsz-2013-0294  0.49
2014 Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H. Direct targeting of Rab-GTPase-effector interactions. Angewandte Chemie (International Ed. in English). 53: 2498-503. PMID 24481744 DOI: 10.1002/Anie.201308568  0.352
2014 Eschenbrenner-Lux V, Küchler P, Ziegler S, Kumar K, Waldmann H. An enantioselective inverse-electron-demand imino Diels-Alder reaction. Angewandte Chemie (International Ed. in English). 53: 2134-7. PMID 24470427 DOI: 10.1002/Anie.201309022  0.306
2014 Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PI. The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins. Biophysical Journal. 106: 93-105. PMID 24411241 DOI: 10.1016/J.Bpj.2013.11.024  0.324
2014 Weise K, Sperlich B, Kapoor S, Triola G, Waldmann H, Winter R. Regulation of K-RAS Membrane Association: Calmodulin Versus PDEδ Biophysical Journal. 106: 711a. DOI: 10.1016/J.Bpj.2013.11.3936  0.691
2013 Köhnke M, Delon C, Hastie ML, Nguyen UT, Wu YW, Waldmann H, Goody RS, Gorman JJ, Alexandrov K. Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. Plos One. 8: e81758. PMID 24358126 DOI: 10.1371/Journal.Pone.0081758  0.305
2013 Narayan R, Bauer JO, Strohmann C, Antonchick AP, Waldmann H. Catalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling. Angewandte Chemie (International Ed. in English). 52: 12892-6. PMID 24151037 DOI: 10.1002/Anie.201307392  0.796
2013 Werkmüller A, Triola G, Waldmann H, Winter R. Rotational and translational dynamics of ras proteins upon binding to model membrane systems. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 14: 3698-705. PMID 24115726 DOI: 10.1002/Cphc.201300617  0.503
2013 Takayama H, Jia ZJ, Kremer L, Bauer JO, Strohmann C, Ziegler S, Antonchick AP, Waldmann H. Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection. Angewandte Chemie (International Ed. in English). 52: 12404-8. PMID 24115579 DOI: 10.1002/Anie.201306948  0.727
2013 Potowski M, Antonchick AP, Waldmann H. Catalytic asymmetric exo-selective [6+3] cycloaddition of iminoesters with fulvenes. Chemical Communications (Cambridge, England). 49: 7800-2. PMID 23884088 DOI: 10.1039/C3Cc43824D  0.735
2013 Weise K, Huster D, Kapoor S, Triola G, Waldmann H, Winter R. Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins. Faraday Discussions. 161: 549-61; discussion 5. PMID 23805758 DOI: 10.1039/C2Fd20100C  0.699
2013 Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 497: 638-42. PMID 23698361 DOI: 10.1038/Nature12205  0.337
2013 Antonchick AP, López-Tosco S, Parga J, Sievers S, Schürmann M, Preut H, Höing S, Schöler HR, Sterneckert J, Rauh D, Waldmann H. Highly enantioselective catalytic synthesis of neurite growth-promoting secoyohimbanes. Chemistry & Biology. 20: 500-9. PMID 23601639 DOI: 10.1016/J.Chembiol.2013.03.011  0.722
2013 Kapoor S, Werkmüller A, Goody RS, Waldmann H, Winter R. Pressure modulation of Ras-membrane interactions and intervesicle transfer. Journal of the American Chemical Society. 135: 6149-56. PMID 23560466 DOI: 10.1021/Ja312671J  0.698
2013 Ziegler S, Pries V, Hedberg C, Waldmann H. Target identification for small bioactive molecules: finding the needle in the haystack. Angewandte Chemie (International Ed. in English). 52: 2744-92. PMID 23418026 DOI: 10.1002/Anie.201208749  0.326
2013 Zimmermann TJ, Roy S, Martinez NE, Ziegler S, Hedberg C, Waldmann H. Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization. Chembiochem : a European Journal of Chemical Biology. 14: 295-300. PMID 23364933 DOI: 10.1002/Cbic.201200711  0.319
2013 Eschenbrenner-Lux V, Dückert H, Khedkar V, Bruss H, Waldmann H, Kumar K. Cascade syntheses routes to the centrocountins. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 2294-304. PMID 23319417 DOI: 10.1002/Chem.201203714  0.37
2013 Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nature Chemistry. 5: 21-8. PMID 23247173 DOI: 10.1038/Nchem.1506  0.345
2013 Zimmermann TJ, Bürger M, Tashiro E, Kondoh Y, Martinez NE, Görmer K, Rosin-Steiner S, Shimizu T, Ozaki S, Mikoshiba K, Watanabe N, Hall D, Vetter IR, Osada H, Hedberg C, ... Waldmann H, et al. Boron-based inhibitors of acyl protein thioesterases 1 and 2. Chembiochem : a European Journal of Chemical Biology. 14: 115-22. PMID 23239555 DOI: 10.1002/Cbic.201200571  0.373
2013 Voigt T, Gerding-Reimers C, Ngoc Tran TT, Bergmann S, Lachance H, Schölermann B, Brockmeyer A, Janning P, Ziegler S, Waldmann H. A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin. Angewandte Chemie (International Ed. in English). 52: 410-4. PMID 23080551 DOI: 10.1002/Anie.201205728  0.595
2013 Werkmüller A, Triola G, Waldmann H, Winter R. Inside Cover: Rotational and Translational Dynamics of Ras Proteins upon Binding to Model Membrane Systems (ChemPhysChem 16/2013) Chemphyschem. 14: 3634-3634. DOI: 10.1002/Cphc.201390077  0.486
2013 Potowski M, Bauer JO, Strohmann C, Antonchick AP, Waldmann H. Corrigendum: Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides Angewandte Chemie International Edition. 52: 7342-7342. DOI: 10.1002/Anie.201304263  0.71
2013 Potowski M, Bauer JO, Strohmann C, Antonchick AP, Waldmann H. Berichtigung: Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides Angewandte Chemie. 125: 7484-7484. DOI: 10.1002/Ange.201304263  0.71
2012 Matcha K, Madduri AV, Roy S, Ziegler S, Waldmann H, Hirsch AK, Minnaard AJ. Total synthesis of (-)-doliculide, structure-activity relationship studies and its binding to F-actin. Chembiochem : a European Journal of Chemical Biology. 13: 2537-48. PMID 23129522 DOI: 10.1002/Cbic.201200512  0.313
2012 Güldenhaupt J, Rudack T, Bachler P, Mann D, Triola G, Waldmann H, Kötting C, Gerwert K. N-Ras forms dimers at POPC membranes. Biophysical Journal. 103: 1585-93. PMID 23062351 DOI: 10.1016/J.Bpj.2012.08.043  0.304
2012 Sos ML, Dietlein F, Peifer M, Schöttle J, Balke-Want H, Müller C, Koker M, Richters A, Heynck S, Malchers F, Heuckmann JM, Seidel D, Eyers PA, Ullrich RT, Antonchick AP, ... ... Waldmann H, et al. A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 17034-9. PMID 23035247 DOI: 10.1073/Pnas.1207310109  0.697
2012 Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS. Development of selective, potent RabGGTase inhibitors. Journal of Medicinal Chemistry. 55: 8330-40. PMID 22963166 DOI: 10.1021/Jm300624S  0.689
2012 Potowski M, Bauer JO, Strohmann C, Antonchick AP, Waldmann H. Highly enantioselective catalytic [6+3] cycloadditions of azomethine ylides. Angewandte Chemie (International Ed. in English). 51: 9512-6. PMID 22893358 DOI: 10.1002/Anie.201204394  0.71
2012 Kapoor S, Weise K, Erlkamp M, Triola G, Waldmann H, Winter R. The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. European Biophysics Journal : Ebj. 41: 801-13. PMID 22851002 DOI: 10.1007/S00249-012-0841-5  0.697
2012 Weise K, Kapoor S, Werkmüller A, Möbitz S, Zimmermann G, Triola G, Waldmann H, Winter R. Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: membrane delivery instead of extraction. Journal of the American Chemical Society. 134: 11503-10. PMID 22721555 DOI: 10.1021/Ja305518H  0.687
2012 Tnimov Z, Guo Z, Gambin Y, Nguyen UT, Wu YW, Abankwa D, Stigter A, Collins BM, Waldmann H, Goody RS, Alexandrov K. Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. The Journal of Biological Chemistry. 287: 26549-62. PMID 22628549 DOI: 10.1074/Jbc.M112.371294  0.309
2012 Lachance H, Wetzel S, Kumar K, Waldmann H. Charting, navigating, and populating natural product chemical space for drug discovery. Journal of Medicinal Chemistry. 55: 5989-6001. PMID 22537178 DOI: 10.1021/Jm300288G  0.339
2012 Görmer K, Bürger M, Kruijtzer JA, Vetter I, Vartak N, Brunsveld L, Bastiaens PI, Liskamp RM, Triola G, Waldmann H. Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery. Chembiochem : a European Journal of Chemical Biology. 13: 1017-23. PMID 22488913 DOI: 10.1002/Cbic.201200078  0.735
2012 Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. Journal of the American Chemical Society. 134: 7384-91. PMID 22480322 DOI: 10.1021/Ja211305J  0.701
2012 Richter A, Rose R, Hedberg C, Waldmann H, Ottmann C. An optimised small-molecule stabiliser of the 14-3-3-PMA2 protein-protein interaction. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 6520-7. PMID 22467351 DOI: 10.1002/Chem.201103761  0.38
2012 Potowski M, Schürmann M, Preut H, Antonchick AP, Waldmann H. Programmable enantioselective one-pot synthesis of molecules with eight stereocenters. Nature Chemical Biology. 8: 428-30. PMID 22426113 DOI: 10.1038/Nchembio.901  0.722
2012 Das D, Tnimov Z, Nguyen UT, Thimmaiah G, Lo H, Abankwa D, Wu Y, Goody RS, Waldmann H, Alexandrov K. Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro. Chembiochem : a European Journal of Chemical Biology. 13: 674-83. PMID 22351497 DOI: 10.1002/Cbic.201100733  0.381
2012 Samatov TR, Wolf A, Odenwälder P, Bessonov S, Deraeve C, Bon RS, Waldmann H, Lührmann R. Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. Chembiochem : a European Journal of Chemical Biology. 13: 640-4. PMID 22334518 DOI: 10.1002/Cbic.201100790  0.688
2012 Kapoor S, Triola G, Vetter IR, Erlkamp M, Waldmann H, Winter R. Revealing conformational substates of lipidated N-Ras protein by pressure modulation. Proceedings of the National Academy of Sciences of the United States of America. 109: 460-5. PMID 22203965 DOI: 10.1073/pnas.1110553109  0.709
2012 Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, ... ... Waldmann H, et al. Natural product-inspired cascade synthesis yields modulators of centrosome integrity. Nature Chemical Biology. 8: 179-84. PMID 22198731 DOI: 10.1038/Nchembio.758  0.397
2012 Triola G, Waldmann H, Hedberg C. Chemical biology of lipidated proteins. Acs Chemical Biology. 7: 87-99. PMID 22148864 DOI: 10.1021/Cb200460U  0.347
2012 Bürger M, Zimmermann TJ, Kondoh Y, Stege P, Watanabe N, Osada H, Waldmann H, Vetter IR. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. Journal of Lipid Research. 53: 43-50. PMID 22052940 DOI: 10.1194/Jlr.M019851  0.332
2012 Werkmüller A, Denter C, Opitz N, Koch S, Zimmermann G, Triola G, Waldmann H, Winter R. Characterization of the Dynamical Properties of Ras Proteins upon Insertion into Model Biomembrane Systems Biophysical Journal. 102: 77a. DOI: 10.1016/J.Bpj.2011.11.448  0.503
2012 Weise K, Kapoor S, Koch S, Triola G, Waldmann H, Winter R. Ras Isoform-Specific Membrane Interactions: A Molecular Mechanism for Isoform-Specific Ras Signaling Biophysical Journal. 102: 18a. DOI: 10.1016/J.Bpj.2011.11.122  0.702
2011 Wetzel S, Bon RS, Kumar K, Waldmann H. Biology-oriented synthesis. Angewandte Chemie (International Ed. in English). 50: 10800-26. PMID 22038946 DOI: 10.1002/Anie.201007004  0.704
2011 Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A. Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nature Chemical Biology. 7: 942-9. PMID 22002721 DOI: 10.1038/Nchembio.686  0.337
2011 Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, Triola G, Brockmeyer A, Janning P, Böttcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H. Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angewandte Chemie (International Ed. in English). 50: 9838-42. PMID 21905186 DOI: 10.1002/Anie.201102967  0.315
2011 Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H. Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design. Angewandte Chemie (International Ed. in English). 50: 9832-7. PMID 21905185 DOI: 10.1002/Anie.201102965  0.688
2011 Wittstein K, Kumar K, Waldmann H. Gold(I)-catalyzed synthesis of benzoxocines by an 8-endo-dig cyclization. Angewandte Chemie (International Ed. in English). 50: 9076-80. PMID 21866577 DOI: 10.1002/Anie.201103832  0.339
2011 Stöckigt J, Antonchick AP, Wu F, Waldmann H. The Pictet-Spengler reaction in nature and in organic chemistry. Angewandte Chemie (International Ed. in English). 50: 8538-64. PMID 21830283 DOI: 10.1002/Anie.201008071  0.73
2011 Eisenberg S, Beckett AJ, Prior IA, Dekker FJ, Hedberg C, Waldmann H, Ehrlich M, Henis YI. Raft protein clustering alters N-Ras membrane interactions and activation pattern. Molecular and Cellular Biology. 31: 3938-52. PMID 21807892 DOI: 10.1128/Mcb.05570-11  0.307
2011 Yi L, Sun H, Itzen A, Triola G, Waldmann H, Goody RS, Wu YW. One-pot dual-labeling of a protein by two chemoselective reactions. Angewandte Chemie (International Ed. in English). 50: 8287-90. PMID 21761514 DOI: 10.1002/Anie.201100840  0.509
2011 Richter A, Hedberg C, Waldmann H. Enantioselective synthesis of the C10-C20 fragment of fusicoccin A. The Journal of Organic Chemistry. 76: 6694-702. PMID 21755994 DOI: 10.1021/Jo201020V  0.326
2011 Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. Acs Chemical Biology. 6: 900-4. PMID 21732624 DOI: 10.1021/Cb200206W  0.649
2011 Chen YX, Triola G, Waldmann H. Bioorthogonal chemistry for site-specific labeling and surface immobilization of proteins. Accounts of Chemical Research. 44: 762-73. PMID 21648407 DOI: 10.1021/Ar200046H  0.363
2011 Eberhardt L, Kumar K, Waldmann H. Exploring and exploiting biologically relevant chemical space. Current Drug Targets. 12: 1531-46. PMID 21561426 DOI: 10.2174/138945011798109482  0.391
2011 Schuster H, Martinez R, Bruss H, Antonchick AP, Kaiser M, Schürmann M, Waldmann H. Synthesis of the B-seco limonoid scaffold. Chemical Communications (Cambridge, England). 47: 6545-7. PMID 21552600 DOI: 10.1039/C1Cc11388G  0.703
2011 He YP, Tan H, Arve L, Baumann S, Waldmann H, Arndt HD. Biphenomycin B and derivatives: total synthesis and translation inhibition. Chemistry, An Asian Journal. 6: 1546-56. PMID 21548101 DOI: 10.1002/Asia.201000908  0.615
2011 Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Structure-guided development of selective RabGGTase inhibitors. Angewandte Chemie (International Ed. in English). 50: 4957-61. PMID 21520375 DOI: 10.1002/Anie.201101210  0.684
2011 Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Fröhlich R, Habenberger P, Waldmann H, Christmann M. Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile. Angewandte Chemie (International Ed. in English). 50: 3998-4002. PMID 21472928 DOI: 10.1002/Anie.201007790  0.504
2011 Dückert H, Khedkar V, Waldmann H, Kumar K. Lewis base catalyzed [4+2] annulation of electron-deficient chromone-derived heterodienes and acetylenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 5130-7. PMID 21432922 DOI: 10.1002/Chem.201003572  0.312
2011 Vintonyak VV, Waldmann H, Rauh D. Using small molecules to target protein phosphatases. Bioorganic & Medicinal Chemistry. 19: 2145-55. PMID 21420867 DOI: 10.1016/J.Bmc.2011.02.047  0.349
2011 Basu S, Ellinger B, Rizzo S, Deraeve C, Schürmann M, Preut H, Arndt HD, Waldmann H. Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway. Proceedings of the National Academy of Sciences of the United States of America. 108: 6805-10. PMID 21415367 DOI: 10.1073/Pnas.1015269108  0.7
2011 Möcklinghoff S, van Otterlo WA, Rose R, Fuchs S, Zimmermann TJ, Dominguez Seoane M, Waldmann H, Ottmann C, Brunsveld L. Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach. Journal of Medicinal Chemistry. 54: 2005-11. PMID 21381753 DOI: 10.1021/Jm1011116  0.72
2011 Hakki T, Hübel K, Waldmann H, Bernhardt R. The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension. The Journal of Steroid Biochemistry and Molecular Biology. 125: 120-8. PMID 21193036 DOI: 10.1016/J.Jsbmb.2010.12.011  0.317
2011 Weise K, Kapoor S, Denter C, Nikolaus J, Opitz N, Koch S, Triola G, Herrmann A, Waldmann H, Winter R. Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. Journal of the American Chemical Society. 133: 880-7. PMID 21141956 DOI: 10.1021/ja107532q  0.704
2011 Frenzel LP, Feldhaus V, Rusch M, Brinker R, Claasen J, Pallasch CP, Waldmann H, Hallek M, Hedberg C, Wendtner C. Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia Blood. 118: 2829-2829. DOI: 10.1182/Blood.V118.21.2829.2829  0.316
2011 Waldmann H, Bruss H, Dückert H, Kumar K. Synthesis of novel electron-deficient chromone-fused dienes via phosphine catalyzed [4+2] annulation Tetrahedron Letters. 52: 2265-2267. DOI: 10.1016/J.Tetlet.2011.01.151  0.315
2011 Antonchick AP, Schuster H, Bruss H, Schürmann M, Preut H, Rauh D, Waldmann H. Enantioselective synthesis of the spirotryprostatin A scaffold Tetrahedron. 67: 10195-10202. DOI: 10.1016/J.Tet.2011.04.056  0.722
2011 Vintonyak VV, Warburg K, Over B, Hübel K, Rauh D, Waldmann H. Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B Tetrahedron. 67: 6713-6729. DOI: 10.1016/J.Tet.2011.04.026  0.355
2011 Alexandrov K, Wu Y, Blankenfeldt W, Waldmann H, Goody RS. Organization and Function of the Rab Prenylation and Recycling Machinery Enzymes. 29: 147-162. DOI: 10.1016/B978-0-12-381339-8.00008-1  0.336
2011 Stöckigt J, Antonchick AP, Wu F, Waldmann H. Die Pictet-Spengler-Reaktion in der Natur und der organischen Chemie Angewandte Chemie. 123: 8692-8719. DOI: 10.1002/Ange.201008071  0.685
2011 Wetzel S, Bon RS, Kumar K, Waldmann H. Biologie-orientierte Synthese (BIOS) Angewandte Chemie. 123: 10990-11018. DOI: 10.1002/Ange.201007004  0.638
2010 Yi L, Sun H, Wu YW, Triola G, Waldmann H, Goody RS. A highly efficient strategy for modification of proteins at the C terminus. Angewandte Chemie (International Ed. in English). 49: 9417-21. PMID 21031382 DOI: 10.1002/Anie.201003834  0.513
2010 Antonchick AP, Gerding-Reimers C, Catarinella M, Schürmann M, Preut H, Ziegler S, Rauh D, Waldmann H. Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nature Chemistry. 2: 735-40. PMID 20729892 DOI: 10.1038/Nchem.730  0.749
2010 Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G, Waldmann H. Synthesis of the Rheb and K-Ras4B GTPases. Angewandte Chemie (International Ed. in English). 49: 6090-5. PMID 20652921 DOI: 10.1002/Anie.201001884  0.759
2010 Triola G, Gerauer M, Görmer K, Brunsveld L, Waldmann H. Solid-phase synthesis of lipidated Ras peptides employing the Ellman sulfonamide linker. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 9585-91. PMID 20648498 DOI: 10.1002/Chem.201001642  0.739
2010 Vintonyak VV, Warburg K, Kruse H, Grimme S, Hübel K, Rauh D, Waldmann H. Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angewandte Chemie (International Ed. in English). 49: 5902-5. PMID 20632348 DOI: 10.1002/Anie.201002138  0.306
2010 Wu YW, Oesterlin LK, Tan KT, Waldmann H, Alexandrov K, Goody RS. Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nature Chemical Biology. 6: 534-40. PMID 20512138 DOI: 10.1038/Nchembio.386  0.339
2010 Gohlke A, Triola G, Waldmann H, Winter R. Influence of the lipid anchor motif of N-ras on the interaction with lipid membranes: a surface plasmon resonance study. Biophysical Journal. 98: 2226-35. PMID 20483331 DOI: 10.1016/J.Bpj.2010.02.005  0.5
2010 Bon RS, Waldmann H. Bioactivity-guided navigation of chemical space. Accounts of Chemical Research. 43: 1103-14. PMID 20481515 DOI: 10.1021/Ar100014H  0.719
2010 Rose R, Erdmann S, Bovens S, Wolf A, Rose M, Hennig S, Waldmann H, Ottmann C. Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions. Angewandte Chemie (International Ed. in English). 49: 4129-32. PMID 20437433 DOI: 10.1002/Anie.200907203  0.325
2010 Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, ... ... Waldmann H, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nature Chemical Biology. 6: 449-56. PMID 20418879 DOI: 10.1038/Nchembio.362  0.801
2010 Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI. The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell. 141: 458-71. PMID 20416930 DOI: 10.1016/J.Cell.2010.04.007  0.741
2010 Waldmann H, Eberhardt L, Wittstein K, Kumar K. Silver catalyzed cascade synthesis of alkaloid ring systems: Concise total synthesis of fascaplysin, homofascaplysin C and analogues Chemical Communications. 46: 4622-4624. PMID 20386812 DOI: 10.1039/C001350A  0.353
2010 Tannert R, Milroy LG, Ellinger B, Hu TS, Arndt HD, Waldmann H. Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. Journal of the American Chemical Society. 132: 3063-77. PMID 20148556 DOI: 10.1021/Ja9095126  0.385
2010 Görmer K, Waldmann H, Triola G. Efficient microwave-assisted synthesis of unsymmetrical disulfides. The Journal of Organic Chemistry. 75: 1811-3. PMID 20121046 DOI: 10.1021/Jo902695A  0.329
2010 Weinrich D, Lin PC, Jonkheijm P, Nguyen UT, Schröder H, Niemeyer CM, Alexandrov K, Goody R, Waldmann H. Oriented immobilization of farnesylated proteins by the thiol-ene reaction. Angewandte Chemie (International Ed. in English). 49: 1252-7. PMID 20069617 DOI: 10.1002/Anie.200906190  0.321
2010 Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, ... ... Waldmann H, et al. Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization. Chembiochem : a European Journal of Chemical Biology. 11: 235-47. PMID 20043307 DOI: 10.1002/Cbic.200900559  0.456
2010 Wilk W, Zimmermann TJ, Kaiser M, Waldmann H. Principles, implementation, and application of biology-oriented synthesis (BIOS). Biological Chemistry. 391: 491-7. PMID 20030592 DOI: 10.1515/Bc.2010.013  0.349
2010 Weise K, Triola G, Janosch S, Waldmann H, Winter R. Visualizing association of lipidated signaling proteins in heterogeneous membranes--partitioning into subdomains, lipid sorting, interfacial adsorption, and protein association. Biochimica Et Biophysica Acta. 1798: 1409-17. PMID 20025847 DOI: 10.1016/J.Bbamem.2009.12.006  0.492
2010 Vogel A, Reuther G, Roark MB, Tan KT, Waldmann H, Feller SE, Huster D. Backbone conformational flexibility of the lipid modified membrane anchor of the human N-Ras protein investigated by solid-state NMR and molecular dynamics simulation. Biochimica Et Biophysica Acta. 1798: 275-85. PMID 19819220 DOI: 10.1016/J.Bbamem.2009.09.023  0.313
2010 Wilk W, Nören-Müller A, Kaiser M, Waldmann H. Biology-oriented combined solid- and solution-phase synthesis of a macroline-like compound collection. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11976-84. PMID 19784970 DOI: 10.1002/Chem.200901797  0.344
2010 Waldmann H, Antonchick A, Gerding-Reimers C, Catarinella M, Schürmann M, Preut H, Ziegler S, Rauh D. Enantioselective Synthesis of Spirooxindoles Inspired by Natural Products Synfacts. 2010: 1379-1379. DOI: 10.1055/s-0030-1258906  0.701
2010 Weise K, Triola G, Koch S, Waldmann H, Winter R. Interactions of Lipidated Ras Proteins With Raft Membranes Studied By Time-Lapse Atomic Force Microscopy Biophysical Journal. 98: 19a-20a. DOI: 10.1016/J.Bpj.2009.12.119  0.506
2010 Lin P, Weinrich D, Waldmann H. Protein Biochips: Oriented Surface Immobilization of Proteins Macromolecular Chemistry and Physics. 211: 136-144. DOI: 10.1002/Macp.200900539  0.337
2010 Seitz O, Heinemann I, Mattes A, Waldmann H. ChemInform Abstract: Synthetic Peptide Conjugates - Tailor-Made Probes for the Biology of Protein Modification and Protein Processing Cheminform. 32: no-no. DOI: 10.1002/chin.200124237  0.484
2010 Pathak T, Waldmann H. ChemInform Abstract: Enzymic Protecting Group Techniques in Organic Synthesis Cheminform. 32: no-no. DOI: 10.1002/chin.200121247  0.531
2010 PATHAK T, WALDMANN H. ChemInform Abstract: Enzymes and Protecting Group Chemistry Cheminform. 29: no-no. DOI: 10.1002/chin.199835350  0.515
2010 KUNZ H, UNVERZAGT C, DOMBO B, KOSCH W, WALDMANN H. ChemInform Abstract: Synthesis of Glycopeptide Partial Structures of Virus Coat Glycoproteins Cheminform. 26: no-no. DOI: 10.1002/chin.199515318  0.37
2010 WALDMANN H, HEUSER A, BRAUN P, SCHULTZ M, KUNZ H. ChemInform Abstract: New Enzymic Methods for the Selective Functionalization of Carbohydrate Derivatives Cheminform. 24: no-no. DOI: 10.1002/chin.199333292  0.394
2010 WALDMANN H, HEUSER A, BRAUN P, KUNZ H. ChemInform Abstract: New Enzymatic Protecting Group Techniques for Peptide and Carbohydrate Chemistry. Cheminform. 24: no-no. DOI: 10.1002/chin.199313067  0.387
2010 BRAUN P, WALDMANN H, VOGT W, KUNZ H. ChemInform Abstract: Selective Enzymatic Removal of Protecting Groups: n-Heptyl Esters as Carboxy Protecting Functions in Peptide Synthesis. Cheminform. 22: no-no. DOI: 10.1002/chin.199117251  0.428
2010 SCHULTZ M, WALDMANN H, KUNZ H, VOGT W. ChemInform Abstract: Chemoenzymatic “Chiral-Pool” Synthesis of (+)-exo-Brevicomin from Carbohydrates Using Fructose 1,6-Diphosphate Aldolase. Cheminform. 22: no-no. DOI: 10.1002/chin.199102093  0.436
2009 Tan KT, Guiu-Rozas E, Bon RS, Guo Z, Delon C, Wetzel S, Arndt S, Alexandrov K, Waldmann H, Goody RS, Wu YW, Blankenfeldt W. Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. Journal of Medicinal Chemistry. 52: 8025-37. PMID 19894725 DOI: 10.1021/Jm901117D  0.712
2009 Vogel A, Reuther G, Weise K, Triola G, Nikolaus J, Tan KT, Nowak C, Herrmann A, Waldmann H, Winter R, Huster D. The lipid modifications of Ras that sense membrane environments and induce local enrichment. Angewandte Chemie (International Ed. in English). 48: 8784-7. PMID 19830755 DOI: 10.1002/Anie.200903396  0.471
2009 Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hübel K, Kaiser M, Waldmann H. The Ras pathway modulator melophlin A targets dynamins. Angewandte Chemie (International Ed. in English). 48: 7240-5. PMID 19722243 DOI: 10.1002/Anie.200902023  0.344
2009 Westerlind U, Schröder H, Hobel A, Gaidzik N, Kaiser A, Niemeyer CM, Schmitt E, Waldmann H, Kunz H. Tumor-associated MUC1 tandem-repeat glycopeptide microarrays to evaluate serum- and monoclonal-antibody specificity. Angewandte Chemie (International Ed. in English). 48: 8263-7. PMID 19718733 DOI: 10.1002/Anie.200902963  0.396
2009 Wetzel S, Klein K, Renner S, Rauh D, Oprea TI, Mutzel P, Waldmann H. Interactive exploration of chemical space with Scaffold Hunter. Nature Chemical Biology. 5: 581-3. PMID 19561620 DOI: 10.1038/Nchembio.187  0.31
2009 Renner S, Van Otterlo WAL, Dominguez Seoane M, Möcklinghoff S, Hofmann B, Wetzel S, Schuffenhauer A, Ertl P, Oprea TI, Steinhilber D, Brunsveld L, Rauh D, Waldmann H. Bioactivity-guided mapping and navigation of chemical space Nature Chemical Biology. 5: 585-592. PMID 19561619 DOI: 10.1038/Nchembio.188  0.734
2009 Vintonyak VV, Antonchick AP, Rauh D, Waldmann H. The therapeutic potential of phosphatase inhibitors Current Opinion in Chemical Biology. 13: 272-283. PMID 19410499 DOI: 10.1016/J.Cbpa.2009.03.021  0.714
2009 Walther T, Renner S, Waldmann H, Arndt HD. Synthesis and structure-activity correlation of brunsvicamide-inspired cyclopeptide collection Chembiochem. 10: 1153-1162. PMID 19360807 DOI: 10.1002/Cbic.200900035  0.334
2009 Kumar K, Waldmann H. Synthesis of natural product inspired compound collections Angewandte Chemie - International Edition. 48: 3224-3242. PMID 19267376 DOI: 10.1002/Anie.200803437  0.362
2009 Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K. Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature Chemical Biology. 5: 227-35. PMID 19219049 DOI: 10.1038/Nchembio.149  0.698
2009 Waldmann H. Killing 84 birds with one stone Nature Chemical Biology. 5: 76-77. PMID 19148173 DOI: 10.1038/Nchembio0209-76  0.339
2009 Weise K, Triola G, Brunsveld L, Waldmann H, Winter R. Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. Journal of the American Chemical Society. 131: 1557-64. PMID 19133719 DOI: 10.1016/J.Bpj.2008.12.3224  0.762
2009 Wilk W, Waldmann H, Kaiser M. γ-Pyrone natural products-A privileged compound class provided by nature Bioorganic and Medicinal Chemistry. 17: 2304-2309. PMID 19042133 DOI: 10.1016/J.Bmc.2008.11.001  0.347
2009 Alexander M, Gerauer M, Pechlivanis M, Popkirova B, Dvorsky R, Brunsveld L, Waldmann H, Kuhlmann J. Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein. Chembiochem : a European Journal of Chemical Biology. 10: 98-108. PMID 18846587 DOI: 10.1002/Cbic.200800275  0.742
2009 Brunsveld L, Waldmann H, Huster D. Membrane binding of lipidated Ras peptides and proteins - The structural point of view Biochimica Et Biophysica Acta - Biomembranes. 1788: 273-288. PMID 18771652 DOI: 10.1016/J.Bbamem.2008.08.006  0.748
2009 Triola G, Wetzel S, Ellinger B, Koch MA, Hübel K, Rauh D, Waldmann H. ATP competitive inhibitors of d-alanine-d-alanine ligase based on protein kinase inhibitor scaffolds Bioorganic and Medicinal Chemistry. 17: 1079-1087. PMID 18321716 DOI: 10.1016/J.Bmc.2008.02.046  0.312
2009 KUNZ H, WALDMANN H, UNVERZAGT C. Allyl ester as temporary protecting group for the β-carboxy function of aspartic acid International Journal of Peptide and Protein Research. 26: 493-497. DOI: 10.1111/J.1399-3011.1985.Tb01016.X  0.505
2009 Ludolph B, Waldmann H. Solid-phase synthesis of benzodiazepinediones mimicking the C-terminus of the H-Ras protein Tetrahedron Letters. 50: 3148-3150. DOI: 10.1016/J.Tetlet.2009.01.016  0.331
2009 Gohlke A, Triola G, Waldmann H, Meister A, Blume A, Winter R. Influence of Lipid Modifications of NRas on the Interaction with different Model Biomembranes and their Orientation at the Lipid Interface Biophysical Journal. 96: 612a. DOI: 10.1016/J.Bpj.2008.12.3239  0.496
2009 Vogel A, Reuther G, Tan K, Waldmann H, Brown MF, Feller SE, Huster D. Backbone Conformation and Dynamics of the Lipid-Modified Membrane Anchor of Human N-Ras Investigated by Solid-State NMR and Molecular Dynamics Simulations Biophysical Journal. 96: 198a. DOI: 10.1016/J.Bpj.2008.12.1062  0.3
2009 Westerlind U, Schröder H, Hobel A, Gaidzik N, Kaiser A, Niemeyer C, Schmitt E, Waldmann H, Kunz H. Cover Picture: Tumor-Associated MUC1 Tandem-Repeat Glycopeptide Microarrays to Evaluate Serum- and Monoclonal-Antibody Specificity (Angew. Chem. Int. Ed. 44/2009) Angewandte Chemie International Edition. 48: 8151-8151. DOI: 10.1002/Anie.200904924  0.401
2009 Westerlind U, Schröder H, Hobel A, Gaidzik N, Kaiser A, Niemeyer C, Schmitt E, Waldmann H, Kunz H. Titelbild: Tumor-Associated MUC1 Tandem-Repeat Glycopeptide Microarrays to Evaluate Serum- and Monoclonal-Antibody Specificity (Angew. Chem. 44/2009) Angewandte Chemie. 121: 8297-8297. DOI: 10.1002/Ange.200904924  0.398
2009 Vogel A, Reuther G, Weise K, Triola G, Nikolaus J, Tan K, Nowak C, Herrmann A, Waldmann H, Winter R, Huster D. Die Lipidmodifikationen von Ras passen sich an die Membranumgebung an und beeinflussen die lokale Konzentration Angewandte Chemie. 121: 8942-8945. DOI: 10.1002/Ange.200903396  0.443
2008 Jonkheijm P, Weinrich D, Schröder H, Niemeyer CM, Waldmann H. Chemical strategies for generating protein biochips Angewandte Chemie - International Edition. 47: 9618-9647. PMID 19025742 DOI: 10.1002/Anie.200801711  0.313
2008 Güldenhaupt J, Adigüzel Y, Kuhlmann J, Waldmann H, Kötting C, Gerwert K. Secondary structure of lipidated Ras bound to a lipid bilayer. The Febs Journal. 275: 5910-8. PMID 19021766 DOI: 10.1111/J.1742-4658.2008.06720.X  0.314
2008 Waldmann H, He YP, Tan H, Arve L, Arndt HD. Flexible total synthesis of biphenomycin B Chemical Communications. 5562-5564. PMID 18997952 DOI: 10.1039/B811583D  0.626
2008 Bisek N, Wetzel S, Arndt HD, Waldmann H. Synthesis and conformational analysis of stevastelin C3 analogues and their activity against the dual-specific vaccina H1-related phosphatase Chemistry - a European Journal. 14: 8847-8860. PMID 18767075 DOI: 10.1002/Chem.200800692  0.349
2008 Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. The Embo Journal. 27: 2444-56. PMID 18756270 DOI: 10.1038/Emboj.2008.164  0.749
2008 Wong E, Okhonin V, Berezovski MV, Nozaki T, Waldmann H, Alexandrov K, Krylov SN. "Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors. Journal of the American Chemical Society. 130: 11862-3. PMID 18702487 DOI: 10.1021/Ja804544X  0.308
2008 Govindaraju T, Jonkheijm P, Gogolin L, Schroeder H, Becker CF, Niemeyer CM, Waldmann H. Surface immobilization of biomolecules by click sulfonamide reaction. Chemical Communications (Cambridge, England). 3723-5. PMID 18685756 DOI: 10.1039/B806764C  0.56
2008 Waldmann H, Khedkar V, Dückert H, Schürmann M, Oppel IM, Kumar K. Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction Angewandte Chemie - International Edition. 47: 6869-6872. PMID 18661463 DOI: 10.1002/Anie.200802413  0.34
2008 Wang Z, Gu C, Colby T, Shindo T, Balamurugan R, Waldmann H, Kaiser M, Van Der Hoorn RAL. β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana Nature Chemical Biology. 4: 557-563. PMID 18660805 DOI: 10.1038/Nchembio.104  0.677
2008 Nören-Müller A, Wilk W, Saxena K, Schwalbe H, Kaiser M, Waldmann H. Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis. Angewandte Chemie (International Ed. in English). 47: 5973-7. PMID 18604796 DOI: 10.1002/Anie.200801566  0.332
2008 Walther T, Arndt HD, Waldmann H. Solid-support based total synthesis and stereochemical correction of brunsvicamide A Organic Letters. 10: 3199-3202. PMID 18590275 DOI: 10.1021/Ol801064D  0.341
2008 Hübel K, Leßmann T, Waldmann H. Chemical biology - Identification of small molecule modulators of cellular activity by natural product inspired synthesis Chemical Society Reviews. 37: 1361-1374. PMID 18568162 DOI: 10.1039/B704729K  0.372
2008 Mishra R, Bulic B, Sellin D, Jha S, Waldmann H, Winter R. Small-molecule inhibitors of islet amyloid polypeptide fibril formation Angewandte Chemie - International Edition. 47: 4679-4682. PMID 18470855 DOI: 10.1002/Anie.200705372  0.461
2008 Waldmann H, Karunakar GV, Kumar K. Gold(III)-mediated aldol condensations provide efficient access to nitrogen heterocycles Organic Letters. 10: 2159-2162. PMID 18461950 DOI: 10.1021/Ol8005634  0.31
2008 Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angewandte Chemie (International Ed. in English). 47: 3747-50. PMID 18399557 DOI: 10.1002/Anie.200705795  0.67
2008 Triola G, Brunsveld L, Waldmann H. Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction Journal of Organic Chemistry. 73: 3646-3649. PMID 18376863 DOI: 10.1021/Jo800198S  0.737
2008 Waldmann H, Kühn M, Liu W, Kumar K. Reagent-controlled domino synthesis of skeletally-diverse compound collections Chemical Communications. 1211-1213. PMID 18309420 DOI: 10.1039/B717635J  0.357
2008 Kaiser M, Wetzel S, Kumar K, Waldmann H. Biology-inspired synthesis of compound libraries Cellular and Molecular Life Sciences. 65: 1186-1201. PMID 18193390 DOI: 10.1007/S00018-007-7492-1  0.36
2008 Wetzel S, Renner S, Nören-Müller A, Schuffenhauer A, Ertl P, Waldmann H. BIOS: Similarity-based design of natural product derived compound collections Chemistry Central Journal. 2. DOI: 10.1186/1752-153X-2-S1-P48  0.349
2008 Scheck M, Koch MA, Waldmann H. Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC) Tetrahedron. 64: 4792-4802. DOI: 10.1016/J.Tet.2008.02.106  0.398
2008 Sommer S, Kühn M, Waldmann H. Solid-phase synthesis of [5.5]-spiroketals Advanced Synthesis and Catalysis. 350: 1736-1750. DOI: 10.1002/Adsc.200800154  0.347
2007 Broussy S, Waldmann H. Solid phase synthesis of highly substituted tetrahydropyrans by tandem ene-reaction/intramolecular sakurai cyclization Journal of Combinatorial Chemistry. 9: 1138-1143. PMID 17935301 DOI: 10.1021/Cc7001099  0.34
2007 Corrêa IR, Nören-Müller A, Ambrosi HD, Jakupovic S, Saxena K, Schwalbe H, Kaiser M, Waldmann H. Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Chemistry, An Asian Journal. 2: 1109-26. PMID 17685373 DOI: 10.1002/Asia.200700125  0.424
2007 Wu YW, Tan KT, Waldmann H, Goody RS, Alexandrov K. Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proceedings of the National Academy of Sciences of the United States of America. 104: 12294-9. PMID 17640890 DOI: 10.1073/Pnas.0701817104  0.337
2007 Ulaczyk-Lesanko A, Pelletier E, Lee M, Prinz H, Waldmann H, Hall DG. Optimization of three- and four-component reactions for polysubstituted piperidines: application to the synthesis and preliminary biological screening of a prototype library. Journal of Combinatorial Chemistry. 9: 695-703. PMID 17521171 DOI: 10.1021/Cc0700344  0.339
2007 Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H. Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chemistry & Biology. 14: 443-51. PMID 17462579 DOI: 10.1016/J.Chembiol.2007.02.008  0.374
2007 Umarye JD, Leßmann T, García AB, Mamane V, Sommer S, Waldmann H. Biology-oriented synthesis of stereochemically diverse natural-product- derived compound collections by iterative allylations on a solid support Chemistry - a European Journal. 13: 3305-3319. PMID 17310497 DOI: 10.1002/Chem.200601698  0.363
2007 Nguyen UT, Cramer J, Gomis J, Reents R, Gutierrez-Rodriguez M, Goody RS, Alexandrov K, Waldmann H. Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem : a European Journal of Chemical Biology. 8: 408-23. PMID 17279592 DOI: 10.1002/Cbic.200600440  0.359
2007 de Araújo AD, Palomo JM, Cramer J, Seitz O, Alexandrov K, Waldmann H. Diels-Alder ligation of peptides and proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 6095-109. PMID 16807971 DOI: 10.1002/Chem.200600148  0.562
2007 Wetzel S, Schuffenhauer A, Roggo S, Ertl P, Waldmann H. Cheminformatic analysis of natural products and their chemical space Chimia. 61: 355-360. DOI: 10.2533/Chimia.2007.355  0.3
2007 Hu TS, Tannert R, Arndt HD, Waldmann H. Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions Chemical Communications. 3942-3944. DOI: 10.1039/B710650E  0.335
2007 Mamane V, García AB, Umarye JD, Lessmann T, Sommer S, Waldmann H. Stereoselective allylation of aldehydes on solid support and its application in biology-oriented synthesis (BIOS) Tetrahedron. 63: 5754-5767. DOI: 10.1016/J.Tet.2007.01.041  0.354
2007 Umarye J, Leßmann T, García A, Mamane V, Sommer S, Waldmann H. Cover Picture: Biology-Oriented Synthesis of Stereochemically Diverse Natural-Product-Derived Compound Collections by Iterative Allylations on a Solid Support (Chem. Eur. J. 12/2007) Chemistry - a European Journal. 13: 3277-3277. DOI: 10.1002/Chem.200790036  0.351
2006 Garcia AB, Lessmann T, Umarye JD, Mamane V, Sommer S, Waldmann H. Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase. Chemical Communications (Cambridge, England). 3868-70. PMID 17268653 DOI: 10.1039/B607816H  0.319
2006 Reuther G, Tan KT, Vogel A, Nowak C, Arnold K, Kuhlmann J, Waldmann H, Huster D. The lipidated membrane anchor of full length N-Ras protein shows an extensive dynamics as revealed by solid-state NMR spectroscopy. Journal of the American Chemical Society. 128: 13840-6. PMID 17044712 DOI: 10.1021/Ja063635S  0.338
2006 Brunsveld L, Kuhlmann J, Alexandrov K, Wittinghofer A, Goody RS, Waldmann H. Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angewandte Chemie (International Ed. in English). 45: 6622-46. PMID 17031879 DOI: 10.1002/Anie.200600855  0.763
2006 Brunsveld L, Kuhlmann J, Waldmann H. Synthesis of palmitoylated Ras-peptides and -proteins. Methods (San Diego, Calif.). 40: 151-65. PMID 17012027 DOI: 10.1016/J.Ymeth.2006.04.014  0.745
2006 Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology. 2: 518-28. PMID 16983387 DOI: 10.1038/Nchembio818  0.74
2006 Lessmann T, Waldmann H. Enantioselective synthesis on the solid phase. Chemical Communications (Cambridge, England). 3380-9. PMID 16896470 DOI: 10.1039/B602822E  0.349
2006 Müller D, Krick A, Kehraus S, Mehner C, Hart M, Küpper FC, Saxena K, Prinz H, Schwalbe H, Janning P, Waldmann H, König GM. Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. Journal of Medicinal Chemistry. 49: 4871-8. PMID 16884299 DOI: 10.1021/Jm060327W  0.331
2006 Reuther G, Tan KT, Köhler J, Nowak C, Pampel A, Arnold K, Kuhlmann J, Waldmann H, Huster D. Structural model of the membrane-bound C terminus of lipid-modified human N-ras protein. Angewandte Chemie (International Ed. in English). 45: 5387-90. PMID 16847854 DOI: 10.1002/Anie.200504266  0.308
2006 Nören-Müller A, Reis-Corrêa I, Prinz H, Rosenbaum C, Saxena K, Schwalbe HJ, Vestweber D, Cagna G, Schunk S, Schwarz O, Schiewe H, Waldmann H. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 10606-11. PMID 16809424 DOI: 10.1073/Pnas.0601490103  0.81
2006 Meister A, Nicolini C, Waldmann H, Kuhlmann J, Kerth A, Winter R, Blume A. Insertion of lipidated Ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS). Biophysical Journal. 91: 1388-401. PMID 16731561 DOI: 10.1529/Biophysj.106.084624  0.515
2006 Seibert SF, Eguereva E, Krick A, Kehraus S, Voloshina E, Raabe G, Fleischhauer J, Leistner E, Wiese M, Prinz H, Alexandrov K, Janning P, Waldmann H, König GM. Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases. Organic & Biomolecular Chemistry. 4: 2233-40. PMID 16729132 DOI: 10.1039/B601386D  0.307
2006 Watzke A, Gutierrez-Rodriguez M, Köhn M, Wacker R, Schroeder H, Breinbauer R, Kuhlmann J, Alexandrov K, Niemeyer CM, Goody RS, Waldmann H. A generic building block for C- and N-terminal protein-labeling and protein-immobilization. Bioorganic & Medicinal Chemistry. 14: 6288-306. PMID 16725326 DOI: 10.1016/J.Bmc.2006.05.006  0.345
2006 Basu S, Waldmann H. Regioselectivity in the formation of small- and medium-sized cyclic ethers by diene-ene ring-closing metathesis. The Journal of Organic Chemistry. 71: 3977-9. PMID 16674078 DOI: 10.1021/Jo052367Y  0.625
2006 Biel M, Deck P, Giannis A, Waldmann H. Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 4121-43. PMID 16528788 DOI: 10.1002/Chem.200501128  0.364
2006 Dursina B, Reents R, Delon C, Wu Y, Kulharia M, Thutewohl M, Veligodsky A, Kalinin A, Evstifeev V, Ciobanu D, Szedlacsek SE, Waldmann H, Goody RS, Alexandrov K. Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. Journal of the American Chemical Society. 128: 2822-35. PMID 16506760 DOI: 10.1021/Ja052196E  0.365
2006 Goody RS, Durek T, Waldmann H, Brunsveld L, Alexandrov K. Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases. Methods in Enzymology. 403: 29-42. PMID 16473575 DOI: 10.1016/S0076-6879(05)03004-1  0.762
2006 Pylypenko O, Rak A, Durek T, Kushnir S, Dursina BE, Thomae NH, Constantinescu AT, Brunsveld L, Watzke A, Waldmann H, Goody RS, Alexandrov K. Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. The Embo Journal. 25: 13-23. PMID 16395334 DOI: 10.1038/Sj.Emboj.7600921  0.741
2006 Gottlieb D, Grunwald C, Nowak C, Kuhlmann J, Waldmann H. Intein-mediated in vitro synthesis of lipidated Ras proteins. Chemical Communications (Cambridge, England). 260-2. PMID 16391727 DOI: 10.1039/B511736D  0.339
2006 Nicolini C, Baranski J, Schlummer S, Palomo J, Lumbierres-Burgues M, Kahms M, Kuhlmann J, Sanchez S, Gratton E, Waldmann H, Winter R. Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. Journal of the American Chemical Society. 128: 192-201. PMID 16390147 DOI: 10.1021/Ja055779X  0.471
2006 Lumbierres M, Palomo JM, Kragol G, Roehrs S, Müller O, Waldmann H. Solid-phase synthesis of lipidated peptides. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 7405-15. PMID 16193522 DOI: 10.1002/Chem.200500476  0.329
2006 Bialy L, Waldmann H. Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angewandte Chemie (International Ed. in English). 44: 3814-39. PMID 15900534 DOI: 10.1002/Anie.200461517  0.338
2006 Brunsveld L, Watzke A, Durek T, Alexandrov K, Goody RS, Waldmann H. Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 2756-72. PMID 15729676 DOI: 10.1002/Chem.200401041  0.752
2006 Lumbierres M, Palomo JM, Kragol G, Waldmann H. Solid-phase synthesis of palmitoylated and farnesylated lipopeptides employing the fluoride-labile PTMSEL linker Tetrahedron Letters. 47: 2671-2674. DOI: 10.1016/J.Tetlet.2006.02.109  0.3
2006 Arve L, Voigt T, Waldmann H. Charting Biological and Chemical Space: PSSC and SCONP as Guiding Principles for the Development of Compound Collections Based on Natural Product Scaffolds. Cheminform. 37. DOI: 10.1002/Qsar.200540213  0.599
2006 Arve L, Voigt T, Waldmann H. Charting biological and chemical space: PSSC and SCONP as guiding principles for the development of compound collections based on natural product scaffolds Qsar and Combinatorial Science. 25: 449-456. DOI: 10.1002/qsar.200540213  0.506
2006 Röttger S, Waldmann H. Solid-Phase Synthesis of Decalin Scaffolds by Robinson Annulation with Immobilised Nazarov Reagents European Journal of Organic Chemistry. 2006: 2093-2099. DOI: 10.1002/Ejoc.200500917  0.339
2006 Brunsveld L, Kuhlmann J, Alexandrov K, Wittinghofer A, Goody RS, Waldmann H. Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion Angewandte Chemie. 118: 6774-6798. DOI: 10.1002/Ange.200600855  0.303
2006 Sanz MA, Voigt T, Waldmann H. Enantioselective catalysis on the solid phase: Synthesis of natural product-derived tetrahydropyrans employing the enantioselective oxa-Diels-Alder reaction Advanced Synthesis and Catalysis. 348: 1511-1515. DOI: 10.1002/Adsc.200606026  0.574
2005 Balamurugan R, Dekker FJ, Waldmann H. Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC). Molecular Biosystems. 1: 36-45. PMID 16880961 DOI: 10.1039/B503623B  0.705
2005 Koch MA, Schuffenhauer A, Scheck M, Wetzel S, Casaulta M, Odermatt A, Ertl P, Waldmann H. Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proceedings of the National Academy of Sciences of the United States of America. 102: 17272-7. PMID 16301544 DOI: 10.1073/Pnas.0503647102  0.347
2005 Sommer S, Waldmann H. Solid phase synthesis of a spiro[5.5]ketal library. Chemical Communications (Cambridge, England). 5684-6. PMID 16292390 DOI: 10.1039/B511177C  0.368
2005 Weide T, Arve L, Prinz H, Waldmann H, Kessler H. 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 59-63. PMID 16236508 DOI: 10.1016/J.Bmcl.2005.09.051  0.348
2005 Manger M, Scheck M, Prinz H, von Kries JP, Langer T, Saxena K, Schwalbe H, Fürstner A, Rademann J, Waldmann H. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach. Chembiochem : a European Journal of Chemical Biology. 6: 1749-53. PMID 16196020 DOI: 10.1002/Cbic.200500171  0.353
2005 Vogel A, Katzka CP, Waldmann H, Arnold K, Brown MF, Huster D. Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR. Journal of the American Chemical Society. 127: 12263-72. PMID 16131204 DOI: 10.1021/Ja051856C  0.321
2005 Deck P, Pendzialek D, Biel M, Wagner M, Popkirova B, Ludolph B, Kragol G, Kuhlmann J, Giannis A, Waldmann H. Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors. Angewandte Chemie (International Ed. in English). 44: 4975-80. PMID 16003812 DOI: 10.1002/Anie.200462625  0.34
2005 Dekker FJ, Koch MA, Waldmann H. Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics. Current Opinion in Chemical Biology. 9: 232-9. PMID 15939324 DOI: 10.1016/J.Cbpa.2005.03.003  0.375
2005 Koch MA, Waldmann H. Protein structure similarity clustering and natural product structure as guiding principles in drug discovery. Drug Discovery Today. 10: 471-83. PMID 15809193 DOI: 10.1016/S1359-6446(05)03419-7  0.353
2005 Watzke A, Brunsveld L, Durek T, Alexandrov K, Rak A, Goody RS, Waldmann H. Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Organic & Biomolecular Chemistry. 3: 1157-64. PMID 15785799 DOI: 10.1039/B417573E  0.764
2005 Rosenbaum C, Röhrs S, Müller O, Waldmann H. Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues. Journal of Medicinal Chemistry. 48: 1179-87. PMID 15715484 DOI: 10.1021/Jm0499099  0.315
2005 Reents R, Wagner M, Schlummer S, Kuhlmann J, Waldmann H. Synthesis and application of fluorescent ras proteins for live-cell imaging. Chembiochem : a European Journal of Chemical Biology. 6: 86-94. PMID 15637662 DOI: 10.1002/Cbic.200400233  0.341
2005 Durek T, Alexandrov K, Goody RS, Hildebrand A, Heinemann I, Waldmann H. Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. Journal of the American Chemical Society. 126: 16368-78. PMID 15600338 DOI: 10.1021/Ja046164N  0.366
2005 Dursina BE, Reents R, Niculae A, Veligodsky A, Breitling R, Pyatkov K, Waldmann H, Goody RS, Alexandrov K. A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins. Protein Expression and Purification. 39: 71-81. PMID 15596362 DOI: 10.1016/J.Pep.2004.09.015  0.35
2005 Bialy L, Waldmann H. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 2759-80. PMID 15195307 DOI: 10.1002/Chem.200305543  0.381
2005 Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, Müller O, Waldmann H. Cover Picture: Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity (Eur. J. Org. Chem. 22/2005) European Journal of Organic Chemistry. 2005: 4731-4731. DOI: 10.1002/Ejoc.200590044  0.363
2005 Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, Müller O, Waldmann H. Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity European Journal of Organic Chemistry. 2005: 4773-4788. DOI: 10.1002/Ejoc.200500605  0.394
2004 Koch MA, Wittenberg LO, Basu S, Jeyaraj DA, Gourzoulidou E, Reinecke K, Odermatt A, Waldmann H. Compound library development guided by protein structure similarity clustering and natural product structure. Proceedings of the National Academy of Sciences of the United States of America. 101: 16721-6. PMID 15548605 DOI: 10.1073/Pnas.0404719101  0.677
2004 Fürstner A, Reinecke K, Prinz H, Waldmann H. The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors Chembiochem. 5: 1575-1579. PMID 15515092 DOI: 10.1002/Cbic.200400135  0.517
2004 Soulère L, Aldrich C, Daumke O, Gail R, Kissau L, Wittinghofer A, Waldmann H. Synthesis of GTP-derived Ras ligands Chembiochem. 5: 1448-1453. PMID 15457534 DOI: 10.1002/Cbic.200400133  0.564
2004 Janosch S, Nicolini C, Ludolph B, Peters C, Völkert M, Hazlet TL, Gratton E, Waldmann H, Winter R. Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation. Journal of the American Chemical Society. 126: 7496-503. PMID 15198596 DOI: 10.1021/Ja049922I  0.481
2004 Peters C, Wolf A, Wagner M, Kuhlmann J, Waldmann H. The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 8531-6. PMID 15163793 DOI: 10.1073/Pnas.0308449101  0.346
2004 Fürstner A, Ruiz-Caro J, Prinz H, Waldmann H. Structure Assignment, Total Synthesis, and Evaluation of the Phosphatase Modulating Activity of Glucolipsin A Journal of Organic Chemistry. 69: 459-467. PMID 14725460 DOI: 10.1021/Jo035079F  0.523
2004 Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H. Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie (International Ed. in English). 43: 224-8. PMID 14695616 DOI: 10.1002/Anie.200352582  0.333
2004 Rosenbaum C, Katzka C, Marzinzik A, Waldmann H. Traceless Fischer indole synthesis on the solid phase. Chemical Communications (Cambridge, England). 1822-3. PMID 12931984 DOI: 10.1039/B305497G  0.321
2004 Waldmann H. At the crossroads of chemistry and biology. Bioorganic & Medicinal Chemistry. 11: 3045-51. PMID 12818666 DOI: 10.1016/S0968-0896(03)00266-9  0.33
2004 Thutewohl M, Waldmann H. Solid-phase synthesis of a pepticinnamin E library. Bioorganic & Medicinal Chemistry. 11: 2591-615. PMID 12757726 DOI: 10.1016/S0968-0896(03)00159-7  0.353
2004 Fürstner A, Feyen F, Prinz H, Waldmann H. Synthesis and evaluation of the antitumor agent TMC-69-6H and a focused library of analogs Tetrahedron. 60: 9543-9558. DOI: 10.1016/J.Tet.2004.06.139  0.567
2004 Reents R, Wagner M, Kuhlmann J, Waldmann H. Synthese und Anwendung fluoreszenzmarkierter Ras-Proteine in der Bildgebung lebender Zellen Angewandte Chemie. 116: 2765-2768. DOI: 10.1002/Ange.200353265  0.303
2003 Fürstner A, Feyen F, Prinz H, Waldmann H. Total Synthesis and Reassessment of the Phosphatase-Inhibitory Activity of the Antitumor Agent TMC-69-6H Angewandte Chemie - International Edition. 42: 5361-5364. PMID 14613177 DOI: 10.1002/Anie.200352268  0.472
2003 Rak A, Pylypenko O, Durek T, Watzke A, Kushnir S, Brunsveld L, Waldmann H, Goody RS, Alexandrov K. Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (New York, N.Y.). 302: 646-50. PMID 14576435 DOI: 10.1126/Science.1087761  0.747
2003 Völkert M, Uwai K, Tebbe A, Popkirova B, Wagner M, Kuhlmann J, Waldmann H. Synthesis and biological activity of photoactivatable N-ras peptides and proteins. Journal of the American Chemical Society. 125: 12749-58. PMID 14558822 DOI: 10.1021/Ja036178D  0.364
2003 Koch MA, Breinbauer R, Waldmann H. Protein structure similarity as guiding principle for combinatorial library design. Biological Chemistry. 384: 1265-72. PMID 14515987 DOI: 10.1515/Bc.2003.140  0.338
2003 Ludolph B, Waldmann H. The synthesis of acid- and base-labile lipopeptides on solid support. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 3683-91. PMID 12898695 DOI: 10.1002/Chem.200304822  0.339
2003 Stieber F, Grether U, Mazitschek R, Soric N, Giannis A, Waldmann H. Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 3282-91. PMID 12866072 DOI: 10.1002/Chem.200304821  0.319
2003 Stieber F, Grether U, Waldmann H. Development of the traceless phenylhydrazide linker for solid-phase synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 3270-81. PMID 12866071 DOI: 10.1002/Chem.200304820  0.347
2003 Kissau L, Stahl P, Mazitschek R, Giannis A, Waldmann H. Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold. Journal of Medicinal Chemistry. 46: 2917-31. PMID 12825933 DOI: 10.1021/Jm0307943  0.359
2003 Thutewohl M, Kissau L, Popkirova B, Karaguni IM, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H. Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library. Bioorganic & Medicinal Chemistry. 11: 2617-26. PMID 12757727 DOI: 10.1016/S0968-0896(03)00160-3  0.358
2003 Huster D, Vogel A, Katzka C, Scheidt HA, Binder H, Dante S, Gutberlet T, Zschörnig O, Waldmann H, Arnold K. Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy Journal of the American Chemical Society. 125: 4070-4079. PMID 12670227 DOI: 10.1021/Ja0289245  0.305
2003 Brohm D, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H. Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors. Angewandte Chemie (International Ed. in English). 41: 307-11. PMID 12491416 DOI: 10.1002/1521-3773(20020118)41:2<307::Aid-Anie307>3.0.Co;2-1  0.356
2003 Reents R, Jeyaraj DA, Waldmann H. Enzymatically cleavable linker groups in polymer-supported synthesis. Drug Discovery Today. 7: 71-6. PMID 11790606 DOI: 10.1016/S1359-6446(01)02088-8  0.318
2003 Bialy L, Waldmann H. Synthesis and Biological Evaluation of Cytostatin Analogues. Cheminform. 34. DOI: 10.1039/B305308N  0.334
2003 Waldmann H. Synthesis of Calicheamitin γ1I Organic Synthesis Set. 371-380. DOI: 10.1002/9783527620784.Ch39A  0.331
2003 Waldmann H. Synthesis of Mitomycins Organic Synthesis Set. 309-314. DOI: 10.1002/9783527620784.Ch33A  0.33
2003 Waldmann H. Synthesis of O‐Glycosides Organic Synthesis Set. 289-299. DOI: 10.1002/9783527620784.Ch31A  0.331
2003 Waldmann H. Chapter 23. General Methods and Reagents for Organic Synthesis: Domino Reactions Organic Synthesis Set. 193-202. DOI: 10.1002/9783527620784.Ch23A  0.303
2003 Waldmann H. Enzymatic Synthesis of O‐Glycosides Organic Synthesis Set. 157-166. DOI: 10.1002/9783527620784.Ch18A  0.344
2002 Breinbauer R, Manger M, Scheck M, Waldmann H. Natural product guided compound library development. Current Medicinal Chemistry. 9: 2129-45. PMID 12470251 DOI: 10.2174/0929867023368773  0.339
2002 Peters C, Wagner M, Völkert M, Waldmann H. Bridging the gap between cell biology and organic chemistry: chemical synthesis and biological application of lipidated peptides and proteins. Die Naturwissenschaften. 89: 381-90. PMID 12435088 DOI: 10.1007/S00114-002-0354-7  0.394
2002 Brohm D, Philippe N, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H. Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors. Journal of the American Chemical Society. 124: 13171-8. PMID 12405845 DOI: 10.1021/Ja027609F  0.411
2002 Völkert M, Koul S, Müller GH, Lehnig M, Waldmann H. Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis. The Journal of Organic Chemistry. 67: 6902-10. PMID 12353981 DOI: 10.1021/Jo0259966  0.686
2002 Kuhlmann J, Tebbe A, Völkert M, Wagner M, Uwai K, Waldmann H. Photoactivatable synthetic Ras proteins: "Baits" for the identification of plasma-membrane-bound binding partners of Ras Angewandte Chemie - International Edition. 41: 2546-2550. PMID 12203529 DOI: 10.1002/1521-3773(20020715)41:14<2546::Aid-Anie2546>3.0.Co;2-E  0.335
2002 Breinbauer R, Vetter IR, Waldmann H. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angewandte Chemie (International Ed. in English). 41: 2879-90. PMID 12203413 DOI: 10.1002/1521-3773(20020816)41:16<2878::Aid-Anie2878>3.0.Co;2-B  0.398
2002 Eisele F, Kuhlmann J, Waldmann H. Synthesis and membrane binding properties of a lipopeptide fragment from influenza virus A hemagglutinin Chemistry - a European Journal. 8: 3362-3376. PMID 12203317 DOI: 10.1002/1521-3765(20020802)8:15<3362::Aid-Chem3362>3.0.Co;2-0  0.314
2002 Ludolph B, Eisele F, Waldmann H. Solid-phase synthesis of lipidated peptides. Journal of the American Chemical Society. 124: 5954-5. PMID 12022824 DOI: 10.1021/Ja025768T  0.332
2002 Alexandrov K, Heinemann I, Durek T, Sidorovitch V, Goody RS, Waldmann H. Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro. Journal of the American Chemical Society. 124: 5648-9. PMID 12010032 DOI: 10.1021/Ja017799E  0.373
2002 Jeyaraj DA, Prinz H, Waldmann H. Synthesis of nucleopeptides by employing an enzyme-labile urethane protecting group. Chemistry: a European Journal. 8: 1879-1887. PMID 12007098 DOI: 10.1002/1521-3765(20020415)8:8<1879::Aid-Chem1879>3.0.Co;2-5  0.336
2002 Scheck M, Waldmann H. Chemo-enzymatic synthesis of the C15–C23 unit of Leptomycin B Canadian Journal of Chemistry. 80: 571-576. DOI: 10.1139/V02-070  0.333
2002 Brohm D, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H. Naturstoffe sind biologisch validierte Startpunkte im Strukturraum zur Entwicklung von Substanzbibliotheken: Festphasensynthese von Analoga des Protein-Phosphatase-Inhibitors Dysidiolid Angewandte Chemie. 114: 319-323. DOI: 10.1002/1521-3757(20020118)114:2<319::Aid-Ange319>3.0.Co;2-E  0.306
2001 Stahl P, Kissau L, Mazitschek R, Huwe A, Furet P, Giannis A, Waldmann H. Total synthesis and biological evaluation of the nakijiquinones. Journal of the American Chemical Society. 123: 11586-93. PMID 11716712 DOI: 10.1021/Ja011413I  0.363
2001 Völkert M, Wagner M, Peters C, Waldmann H. The chemical biology of Ras lipidation. Biological Chemistry. 382: 1133-1145. PMID 11592394 DOI: 10.1515/Bc.2001.143  0.381
2001 Nazaré M, Waldmann H. Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 3363-76. PMID 11531123 DOI: 10.1002/1521-3765(20010803)7:15<3363::Aid-Chem3363>3.0.Co;2-Y  0.368
2001 Machauer R, Waldmann H. Synthesis of lipidated eNOS peptides by combining enzymatic, noble metal- and acid-mediated protecting group techniques with solid phase peptide synthesis and fragment condensation in solution. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 2940-56. PMID 11486971 DOI: 10.1002/1521-3765(20010702)7:13<2933::Aid-Chem2933>3.0.Co;2-E  0.359
2001 Kuhn K, Owen DJ, Bader B, Wittinghofer A, Kuhlmann J, Waldmann H. Synthesis of functional ras lipoproteins and fluorescent derivatives Journal of the American Chemical Society. 123: 1023-1035. PMID 11456655 DOI: 10.1021/Ja002723O  0.37
2001 Kadereit D, Deck P, Heinemann I, Waldmann H. Acid-labile protecting groups for the synthesis of lipidated peptides. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 1184-93. PMID 11322544 DOI: 10.1002/1521-3765(20010316)7:6<1184::Aid-Chem1184>3.0.Co;2-5  0.344
2001 Grether U, Waldmann H. An enzyme-labile safety catch linker for synthesis on a soluble polymeric support. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 959-71. PMID 11303876 DOI: 10.1002/1521-3765(20010302)7:5<959::Aid-Chem959>3.0.Co;2-K  0.311
2001 Huttenloch O, Spieler J, Waldmann H. Chiral bicyclic phosphoramidites--a new class of ligands for asymmetric catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 671-5. PMID 11261665 DOI: 10.1002/1521-3765(20010202)7:3<671::Aid-Chem671>3.0.Co;2-M  0.308
2001 Thomä NH, Iakovenko A, Kalinin A, Waldmann H, Goody RS, Alexandrov K. Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II. Biochemistry. 40: 268-74. PMID 11141079 DOI: 10.1021/Bi002034P  0.311
2001 Meseguer B, Alonso-Díaz D, Griebenow N, Herget T, Waldmann H. Solid-phase synthesis and biological evaluation of a teleocidin library--discovery of a selective PKCdelta down regulator. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3943-57. PMID 11126955 DOI: 10.1002/1521-3765(20001103)6:21<3943::Aid-Chem3943>3.3.Co;2-K  0.389
2001 Seitz O, Heinemann I, Mattes A, Waldmann H. Synthetic peptide conjugates - Tailor-made probes for the biology of protein modification and protein processing Tetrahedron. 57: 2247-2277. DOI: 10.1016/S0040-4020(00)01115-7  0.538
2001 Reents R, Jeyaraj D, Waldmann H. Biocatalysis in Polymer-Supported Synthesis: Enzyme-Labile Linker Groups Advanced Synthesis & Catalysis. 343: 501-513. DOI: 10.1002/1615-4169(200108)343:6/7<501::Aid-Adsc501>3.0.Co;2-D  0.342
2000 Wittinghofer A, Waldmann H. Ras-A Molecular Switch Involved in Tumor Formation. Angewandte Chemie (International Ed. in English). 39: 4192-4214. PMID 29711921 DOI: 10.1002/1521-3773(20001201)39:23<4192::Aid-Anie4192>3.0.Co;2-Y  0.301
2000 Kadereit D, Kuhlmann J, Waldmann H. Linking the fields--the interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation Chembiochem : a European Journal of Chemical Biology. 1: 144-169. PMID 11828408 DOI: 10.1002/1439-7633(20001002)1:3<144::Aid-Cbic144>3.0.Co;2-D  0.386
2000 Gum AG, Kappes-Roth T, Waldmann H. Enzyme-labile protecting groups in peptide synthesis: development of glucose- and galactose-derived urethanes. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3714-21. PMID 11073241 DOI: 10.1002/1521-3765(20001016)6:20<3714::Aid-Chem3714>3.0.Co;2-Z  0.324
2000 Kuder N, Zelinski T, Pathak T, Seitz O, Waldmann H. Synthesis of a triply phosphorylated pentapeptide from human tau-protein. Bioorganic & Medicinal Chemistry. 8: 2433-9. PMID 11058038 DOI: 10.1016/S0968-0896(00)00174-7  0.687
2000 Müller R, Röttele H, Henke H, Waldmann H. Asymmetric steering of the Mannich reaction with phthaloyl amino acids Chemistry: a European Journal. 6: 2032-2043. PMID 10894403 DOI: 10.1002/1521-3765(20000602)6:11<2032::Aid-Chem2032>3.0.Co;2-B  0.344
2000 Sander J, Waldmann H. Enzymatic protecting group techniques for glyco- and phosphopeptide chemistry: synthesis of a glycophosphopeptide from human serum response factor. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 1564-77. PMID 10839174 DOI: 10.1002/(Sici)1521-3765(20000502)6:9<1564::Aid-Chem1564>3.3.Co;2-H  0.352
2000 Bader B, Kuhn K, Owen DJ, Waldmann H, Wittinghofer A, Kuhlmann J. Bioorganic synthesis of lipid-modified proteins for the study of signal transduction Nature. 403: 223-226. PMID 10646611 DOI: 10.1038/35003249  0.383
2000 Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R. Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma. European Journal of Biochemistry. 266: 70-82. PMID 10542052 DOI: 10.1046/J.1432-1327.1999.00815.X  0.31
2000 Nazaré M, Waldmann H. Synthesis of the (9S,18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A Tetrahedron Letters. 41: 625-628. DOI: 10.1016/S0040-4039(99)02135-8  0.313
2000 Kadereit D, Waldmann H. Invited Review Chemoenzymatic Synthesis of Lipidated Peptides Monatshefte Fuer Chemie/Chemical Monthly. 131: 571-584. DOI: 10.1007/S007060070087  0.349
2000 Spieler J, Huttenloch O, Waldmann H. Synthesis of Chiral Amino Alcohols Embodying the Bispidine Framework and Their Application as Ligands in Enantioselectively Catalyzed Additions to CO and CC Groups European Journal of Organic Chemistry. 2000: 391-399. DOI: 10.1002/(Sici)1099-0690(200002)2000:3<391::Aid-Ejoc391>3.0.Co;2-R  0.3
1999 Owen DJ, Alexandrov K, Rostkova E, Scheidig AJ, Goody RS, Waldmann H. Chemo-Enzymatic Synthesis of Fluorescent Rab 7 Proteins: Tools to Study Vesicular Trafficking in Cells. Angewandte Chemie (International Ed. in English). 38: 509-512. PMID 29711783 DOI: 10.1002/(Sici)1521-3773(19990215)38:4<509::Aid-Anie509>3.3.Co;2-V  0.317
1999 Meseguer B, Alonso-Díaz D, Griebenow N, Herget T, Waldmann H. Natural Product Synthesis on Polymeric Supports-Synthesis and Biological Evaluation of an Indolactam Library. Angewandte Chemie. 38: 2902-2906. PMID 10540387 DOI: 10.1002/(Sici)1521-3773(19991004)38:19<2902::Aid-Anie2902>3.0.Co;2-2  0.404
1999 Schmittberger T, Waldmann H. Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-Ras proteins. Bioorganic & Medicinal Chemistry. 7: 749-62. PMID 10400328 DOI: 10.1016/S0968-0896(98)00251-X  0.36
1999 Eisele F, Owen DJ, Waldmann H. Peptide conjugates as tools for the study of biological signal transduction Bioorganic and Medicinal Chemistry. 7: 193-224. PMID 10218812 DOI: 10.1016/S0968-0896(98)00204-1  0.377
1999 Hinterding K, Knebel A, Herrlich P, Waldmann H. Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. 6: 1153-62. PMID 9784857 DOI: 10.1016/S0968-0896(98)00070-4  0.322
1999 Stahl P, Waldmann H. Asymmetric Synthesis of the Nakijiquinones-Selective Inhibitors of the Her-2/Neu Protooncogene. Angewandte Chemie. 38: 3710-3713. DOI: 10.1002/(Sici)1521-3773(19991216)38:24<3710::Aid-Anie3710>3.3.Co;2-8  0.336
1999 Schelhaas M, Nägele E, Kuder N, Bader B, Kuhlmann J, Wittinghofer A, Waldmann H. Chemoenzymatic Synthesis of Biotinylated Ras Peptides and Their Use in Membrane Binding Studies of Lipidated Model Proteins by Surface Plasmon Resonance Chemistry - a European Journal. 5: 1239-1252. DOI: 10.1002/(Sici)1521-3765(19990401)5:4<1239::Aid-Chem1239>3.0.Co;2-N  0.368
1999 Cotté A, Bader B, Kuhlmann J, Waldmann H. Synthesis of the N‐Terminal Lipohexapeptide of Human GαO‐Protein and Fluorescent‐Labeled Analogues for Biological Studies Chemistry: a European Journal. 5: 922-936. DOI: 10.1002/(Sici)1521-3765(19990301)5:3<922::Aid-Chem922>3.0.Co;2-O  0.317
1999 Flohr S, Jungmann V, Waldmann H. Chemoenzymatic Synthesis of Nucleopeptides Chemistry - a European Journal. 5: 669-681. DOI: 10.1002/(Sici)1521-3765(19990201)5:2<669::Aid-Chem669>3.0.Co;2-V  0.311
1999 Bläser E, Kolar P, Fenske D, Goesmann H, Waldmann H. Asymmetric Steering of Oxa Diels–Alder Reactions with Silyloxydienes Employing Proline Esters as Chiral Auxiliary Groups European Journal of Organic Chemistry. 1999: 329-333. DOI: 10.1002/(Sici)1099-0690(199901)1999:1<329::Aid-Ejoc329>3.0.Co;2-Z  0.31
1998 Hinterding K, Alonso-Díaz D, Waldmann H. Organic Synthesis and Biological Signal Transduction. Angewandte Chemie (International Ed. in English). 37: 688-749. PMID 29711371 DOI: 10.1002/(Sici)1521-3773(19980403)37:6<688::Aid-Anie688>3.0.Co;2-B  0.337
1998 Hinterding K, Hagenbuch P, Rétey J, Waldmann H. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angewandte Chemie (International Ed. in English). 37: 1236-1239. PMID 29711232 DOI: 10.1002/(Sici)1521-3773(19980518)37:9<1236::Aid-Anie1236>3.0.Co;2-F  0.338
1998 Pathak T, Waldmann H. Enzymes and protecting group chemistry. Current Opinion in Chemical Biology. 2: 112-20. PMID 9667905 DOI: 10.1016/S1367-5931(98)80042-2  0.578
1998 Schmittberger T, Cotte A, Waldmann H. Synthesis of characteristic lipopeptides of lipid modified proteins employing the allyl ester as protecting group Chemical Communications. 937-938. DOI: 10.1039/A708749G  0.348
1998 Kirschbaum S, Waldmann H. Three-Step Access to the Tricyclic Benzo[a]quinolizine Ring System The Journal of Organic Chemistry. 63: 4936-4946. DOI: 10.1021/Jo972035W  0.312
1998 Nägele E, Schelhaas M, Kuder N, Waldmann H. Chemoenzymatic Synthesis of N-RasLipopeptides Journal of the American Chemical Society. 120: 6889-6902. DOI: 10.1021/Ja9805627  0.376
1998 Brohm D, Waldmann H. Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide Tetrahedron Letters. 39: 3995-3998. DOI: 10.1016/S0040-4039(98)00702-3  0.369
1998 Schlede U, Nazaré M, Waldmann H. Efficient enantioselective synthesis of a β-hydroxyepoxide building block for the construction of macrocyclic natural products Tetrahedron Letters. 39: 1143-1144. DOI: 10.1016/S0040-4039(97)10874-7  0.312
1998 Jungmann V, Waldmann H. An enzymatic protecting group strategy for the synthesis of nucleopeptides Tetrahedron Letters. 39: 1139-1142. DOI: 10.1016/S0040-4039(97)10873-5  0.318
1998 Hinterding K, Hagenbuch P, Rétey J, Waldmann H. Synthesis and in vitro evaluation of the Ras farnesyltransferase inhibitor pepticinnamin E Angewandte Chemie - International Edition. 37: 1236-1239. DOI: 10.1002/(Sici)1521-3765(19990104)5:1<227::Aid-Chem227>3.0.Co;2-X  0.318
1998 Hinterding K, Alonso-Díaz D, Waldmann H. Organische Synthese und biologische Signaltransduktion Angewandte Chemie. 110: 716-780. DOI: 10.1002/(Sici)1521-3757(19980316)110:6<716::Aid-Ange716>3.0.Co;2-8  0.304
1997 Schroeder H, Leventis R, Rex S, Schelhaas M, Nägele E, Waldmann H, Silvius JR. S-acylation and plasma membrane targeting of the farnesylated carboxyl- terminal peptide of N-ras in mammalian fibroblasts Biochemistry. 36: 13102-13109. PMID 9335573 DOI: 10.1021/Bi9709497  0.338
1997 Stöber P, Schelhaas M, Nägele E, Hagenbuch P, Rétey J, Waldmann H. Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase. Bioorganic & Medicinal Chemistry. 5: 75-83. PMID 9043659 DOI: 10.1016/S0968-0896(96)00213-1  0.369
1997 Sebastian D, Waldmann H. Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the Raf-1 kinase Tetrahedron Letters. 38: 2927-2930. DOI: 10.1016/S0040-4039(97)00514-5  0.323
1997 Kappes T, Waldmann H. The tetrabenzylglucosyloxycarbonyl(BGloc)-group-A carbohydrate-derived enzyme-labile urethane protecting group Carbohydrate Research. 305: 341-349. DOI: 10.1016/S0008-6215(97)00224-3  0.347
1997 Kappes T, Waldmann H. Enzymatic Synthesis of Peptide Conjugates: Tools for the Study of Biological Signal Transduction Liebigs Annalen. 1997: 803-813. DOI: 10.1007/Bfb0119220  0.373
1997 Lock R, Waldmann H. Enantioselective Construction of Highly Functionalized Indoloquinolizines—congeners to Polycyclic Indole Alkaloids Chemistry - a European Journal. 3: 143-151. DOI: 10.1002/Chem.19970030122  0.355
1997 Waldmann H, Schelhaas M, Nägele E, Kuhlmann J, Wittinghofer A, Schroeder H, Silvius JR. Chemoenzymatic Synthesis of Fluorescent N-Ras Lipopeptides and Their Use in Membrane Localization Studies in Vivo Angewandte Chemie International Edition in English. 36: 2238-2241. DOI: 10.1002/Anie.199722381  0.304
1996 Pohl T, Waldmann H. Enzymatic Synthesis of a Characteristic Phosphorylated and Glycosylated Peptide Fragment of the Large Subunit of Mammalian RNA Polymerase II Angewandte Chemie International Edition in English. 35: 1720-1723. DOI: 10.1021/Ja970709E  0.334
1996 Lock R, Waldmann H. Asymmetric synthesis of highly functionalized tetracyclic indole bases embodying the basic skeleton of yohimbine- and reserpine type alkaloids Tetrahedron Letters. 37: 2753-2756. DOI: 10.1016/0040-4039(96)00388-7  0.343
1996 Schelhaas M, Glomsda S, Hänsler M, Jakubke H, Waldmann H. Enzymatic Synthesis of Peptides andRas Lipopeptides Employing Choline Ester as a Solubilizing, Protecting, and Activating Group Angewandte Chemie International Edition in English. 35: 106-109. DOI: 10.1002/Anie.199601061  0.314
1995 Waldmann H. Amino Acid Esters: Versatile Chiral Auxiliary Groups for the Asymmetric Synthesis of Nitrogen Heterocycles Synlett. 1995: 133-141. DOI: 10.1055/S-1995-4882  0.307
1995 Nettekoven M, Psiorz M, Waldmann H. Synthesis of enantiomerically pure 4-alkylsubstituted tryptophan derivatives by a combination of organometallic reactions with enantioselective enzymatic transformations Tetrahedron Letters. 36: 1428-1428. DOI: 10.1016/0040-4039(95)00001-S  0.362
1995 Waldmann H, Bläser E, Jansen M, Letschert H. Asymmetric Control of 1,3-Dipolar Cycloaddition Reactions with Azomethine Ylides by Means of Proline Esters as Chiral Auxiliary Groups Chemistry - a European Journal. 1: 150-154. DOI: 10.1002/Chem.19950010209  0.314
1995 Waldmann H, Nägele E. Synthesis of the Palmitoylated and Farnesylated C-Terminal Lipohexapeptide of the Human N-Ras Protein by Employing an Enzymatically Removable Urethane Protecting Group Angewandte Chemie International Edition in English. 34: 2259-2262. DOI: 10.1002/Anie.199522591  0.33
1994 Waldmann H. Asymmetric Hetero Diels-Alder Reactions Synthesis. 1994: 535-551. DOI: 10.1055/S-1994-25519  0.321
1994 Pohl T, Nägele E, Waldmann H. Biocatalysts as chemo- and regioselecting tools in organic synthesis Catalysis Today. 22: 407-426. DOI: 10.1016/0920-5861(94)80115-0  0.328
1994 Waldmann H, Weigerding M, Dreisbach C, Wandrey C. C2-Symmetric Bicyclic Diols as Chiral Ligands in the titanate-catalyzed enantioselective addition of alkylzinc reagents to aldehydes Helvetica Chimica Acta. 77: 2111-2116. DOI: 10.1002/Hlca.19940770803  0.303
1994 Waldmann H, Bläser E, Jansen M, Letschert H. Asymmetric Synthesis of Highly Substituted Pyrrolidines by 1,3-Dipolar Cycloadditions of Azomethine Ylides withN-Acryloylproline Benzyl Ester Angewandte Chemie International Edition in English. 33: 683-685. DOI: 10.1002/Anie.199406831  0.358
1994 Waldmann H, Bläser E, Jansen M, Letschert H. Asymmetrische Synthese hochsubstituierter Pyrrolidine durch 1,3-Dipolare Cycloaddition von Azomethin-Yliden anN-Acryloylprolinbenzylester, Angewandte Chemie. 106: 717-719. DOI: 10.1002/Ange.19941060629  0.326
1993 Braun P, Waldmann H, Kunz H. Chemoenzymatic synthesis of O-glycopeptides carrying the tumor associated TN-antigen structure. Bioorganic & Medicinal Chemistry. 1: 197-207. PMID 8081853 DOI: 10.1016/S0968-0896(00)82122-7  0.452
1993 Waldmann H, Schmidt G, Jansen M, Geb J. Asymmetric Pictet-Spengler reactions employing amino acid esters as mediators of selectivity Tetrahedron Letters. 34: 5867-5870. DOI: 10.1016/S0040-4039(00)73800-7  0.304
1993 Waldmann H, Braun a, Weymann M, Gewehr M. Asymmetric synthesis of indolo[2,3-a]quinolizidin-2-ones - congeners to yohimbine-type alkaloids Tetrahedron. 49: 397-416. DOI: 10.1016/S0040-4020(01)80309-4  0.321
1993 Reidel A, Waldmann H. Enzymatic Protecting Group Techniques in bioorganic synthesis Journal F�R Praktische Chemie/Chemiker-Zeitung. 335: 109-127. DOI: 10.1002/Prac.19933350202  0.313
1992 Braun P, Waldmann H, Kunz H. Selective Enzymatic Removal of Protecting Functions: Heptyl Esters as Carboxy Protecting Groups in Glycopeptide Synthesis Synlett. 1992: 39-40. DOI: 10.1055/S-1992-21258  0.493
1992 Waldmann H, Braun M. Asymmetric tandem Mannich-Michael reactions of amino acid ester imines with Danishefsky's diene The Journal of Organic Chemistry. 57: 4444-4451. DOI: 10.1021/Jo00042A027  0.304
1991 Waldmann H, Braun P, Kunz H. New enzymatic protecting group techniques for the construction of peptides and glycopeptides. Biomedica Biochimica Acta. 50: S243-8. PMID 1820053  0.423
1991 Waldmann H, Braun M, Dräger M. Asymmetric aza Diels-Alder reactions of amino acid ester imines with Brassard's diene Tetrahedron: Asymmetry. 2: 1231-1246. DOI: 10.1016/S0957-4166(00)80023-3  0.322
1991 Braun P, Waldmann H, Vogt W, Kunz H. Selektive enzymatische Schutzgruppenabspaltungen: Der n-Heptylester als Carboxylschutzgruppe in der Peptidsynthese Liebigs Annalen Der Chemie. 1991: 165-170. DOI: 10.1002/Jlac.199119910130  0.49
1991 Waldmann H, Braun M. Asymmetric synthesis of bicyclic amino acid derivatives by Aza-Diels-Alder reactions in aqueous solution Liebigs Annalen Der Chemie. 1991: 1045-1048. DOI: 10.1002/Jlac.1991199101180  0.313
1990 Kunz H, Wernig P, Schilling M, März J, Unverzagt C, Birnbach S, Lang U, Waldmann H. Synthetic tumor-associated glycopeptide antigens. Environmental Health Perspectives. 88: 247-9. PMID 2272318 DOI: 10.2307/3431084  0.451
1990 Waldmann H, März J, Kunz H. Synthesis of 2-acetamido-2-deoxyglucosylasparagine glyco-tripeptides and -pentapeptides by selective C- and N-terminal elongation of the peptide chain. Carbohydrate Research. 196: 75-93. PMID 2161285 DOI: 10.1016/0008-6215(90)84107-6  0.53
1990 Braun P, Waldmann H, Vogt W, Kunz H. Selective Enzymatic Removal of Protecting Functions: Heptyl Esters as Carboxy Protecting Groups in Peptide Synthesis Synlett. 1990: 105-107. DOI: 10.1055/S-1990-21002  0.495
1990 Schultz M, Waldmann H, Vogt W, Kunz H. Stereospecific CC-bond formation with rabbit muscle aldolase - A chemoenzymatic synthesis of (+)-exo-brevicomin Tetrahedron Letters. 31: 867-868. DOI: 10.1016/S0040-4039(00)94649-5  0.473
1990 Schultz M, Waldmann H, Kunz H, Vogt W. Chemoenzymatische „Chiral-Pool”-Synthese von (+)-exo-Brevicomin aus Kohlenhydraten mit Fructose-1,6-diphosphat-Aldolase Liebigs Annalen Der Chemie. 1990: 1019-1024. DOI: 10.1002/Jlac.1990199001184  0.519
1990 Waldmann H. Aminosäureester als chirale Hilfsgruppen in Lewis-Säure-katalysierten Diels-Alder-Reaktionen Liebigs Annalen Der Chemie. 1990: 671-680. DOI: 10.1002/Jlac.1990199001127  0.321
1989 Friedrich-Bochnitschek S, Waldmann H, Kunz H. Allyl esters as carboxy protecting groups in the synthesis of O-glycopeptides The Journal of Organic Chemistry. 54: 751-756. DOI: 10.1021/Jo00265A007  0.466
1989 Bednarski MD, Simon ES, Bischofberger N, Fessner WD, Kim MJ, Lees W, Saito T, Waldmann H, Whitesides GM. Rabbit muscle aldolase as a catalyst in organic synthesis Journal of the American Chemical Society. 111: 627-635. DOI: 10.1021/Ja00184A034  0.608
1989 Waldmann H. Asymmetrische Hetero-Diels-Alder-Reaktionen in wäßriger Lösung unter Verwendung von Aminosäureestern als chiralen Auxiliaren Liebigs Annalen Der Chemie. 1989: 231-238. DOI: 10.1002/Jlac.198919890145  0.307
1989 Kunz H, Waldmann H, März J. Synthese vonN-Glycopeptid-Partialstrukturen der Verknüpfungsregion sowohl der Transmembran-Neuraminidase eines Influenza-Virus als auch des Faktors B des menschlichen Komplementsystems Liebigs Annalen Der Chemie. 1989: 45-49. DOI: 10.1002/Jlac.198919890110  0.427
1989 BEDNARSKI MD, SIMON ES, BISCHOFBERGER N, FESSNER W, KIM M, LEES W, SAITO T, WALDMANN H, WHITESIDES GM. ChemInform Abstract: Rabbit Muscle Aldolase as a Catalyst in Organic Synthesis. Cheminform. 20. DOI: 10.1002/chin.198919286  0.577
1989 BISCHOFBERGER N, WALDMANN H, SAITO T, SIMON ES, LEES W, BEDNARSKI MD, WHITESIDES GM. ChemInform Abstract: Synthesis of Analogues of 1,3-Dihydroxyacetone Phosphate and Glyceraldehyde 3-Phosphate for Use in Studies of Fructose-1,6-diphosphate Aldolase. Cheminform. 20. DOI: 10.1002/chin.198901205  0.565
1988 Waldmann H, Kunz H. 1,3-Dithian-2-ylmethyl esters as two-step carboxy-protecting groups in the synthesis of N-glycopeptides The Journal of Organic Chemistry. 53: 4172-4175. DOI: 10.1021/Jo00253A003  0.45
1988 Bischofberger N, Waldmann H, Saito T, Simon ES, Lees W, Bednarski MD, Whitesides GM. Synthesis of analogs of 1,3-dihydroxyacetone phosphate and glyceraldehyde 3-phosphate for use in studies of fructose-1,6-diphosphate aldolase The Journal of Organic Chemistry. 53: 3457-3465. DOI: 10.1021/Jo00250A010  0.767
1988 Waldmann H. The use of penicillin acylase for selective N-terminal deprotection in peptide synthesis Tetrahedron Letters. 29: 1131-1134. DOI: 10.1016/S0040-4039(00)86668-X  0.314
1988 Waldmann H. Der Phenylacetyl-(PhAc-)Rest als enzymatisch ablösbare Schutzgruppe für Peptide und Kohlenhydrate: Selektive Schutzgruppenabspaltungen mit Penicillin-Acylase Liebigs Annalen Der Chemie. 1988: 1175-1180. DOI: 10.1002/Jlac.198819881212  0.302
1988 Kunz H, Waldmann H, Klinkhammer U. The Allyl Ester as Carboxy-Protecting Group in the Stereoselective Construction of Neuraminic-Acid Glycosides Helvetica Chimica Acta. 71: 1868-1874. DOI: 10.1002/Hlca.19880710804  0.455
1986 Waldmann H, Gygax D, Bednarski MD, Shangraw WR, Whitesides GM. The enzymic utilization of sucrose in the synthesis of amylose and derivatives of amylose, using phosphorylases. Carbohydrate Research. 157: c4-7. PMID 2949832 DOI: 10.1016/0008-6215(86)85078-9  0.761
1986 Bednarski MD, Waldmann HJ, Whitesides GM. Aldolase-catalyzed synthesis of complex C8 and C9 monosaccharides. Tetrahedron Letters. 27: 5807-5810. DOI: 10.1016/S0040-4039(00)85332-0  0.596
1986 KUNZ H, WALDMANN H. ChemInform Abstract: Construction of Disaccharidic N-Glycopeptides. Synthesis of the Transmembrane Neuraminidase Binding Site of Influenza Virus. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198603323  0.373
1985 Kunz H, Waldmann H. Directed Stereoselective Synthesis Of Alpha-N-Acetyl And Beta-N-Acetyl Neuraminic Acid Galactose Disaccharides Using 2-Chloro And 2-Fluoro Derivatives Of Neuraminic Acid Allyl Ester Journal of the Chemical Society, Chemical Communications. 638-640. DOI: 10.1039/C39850000638  0.475
1985 Kunz H, Waldmann H. Synthesis of the Glycopeptide Partial Sequence A80-A84 of Human Fibroblast Interferon Helvetica Chimica Acta. 68: 618-622. DOI: 10.1002/Chin.198535293  0.419
1985 Kunz H, Waldmann H. Construction of DisaccharideN-Glycopeptides?Synthesis of the Linkage Region of the Transmembrance-Neuraminidase of an Influenza Virus Angewandte Chemie International Edition in English. 24: 883-885. DOI: 10.1002/Anie.198508831  0.429
1985 Kunz H, Waldmann H. Aufbau disaccharidischerN-Glycopeptide – Synthese der Verknüpfungsregion der Transmembran-Neuraminidase eines Influenza-Virus Angewandte Chemie. 97: 885-887. DOI: 10.1002/Ange.19850971033  0.435
1984 KUNZ H, WALDMANN H. ChemInform Abstract: ALLYL GROUPS AS MILD AND SELECTIVE CLEAVABLE CARBOXY PROTECTIVE GROUPS FOR THE SYNTHESIS OF SENSITIVE O-GLYCOPEPTIDES Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198415343  0.392
1984 WALDMANN H, KUNZ H. ChemInform Abstract: ALLYL ESTERS AS SELECTIVELY REMOVABLE CARBOXY-PROTECTING FUNCTIONS IN PEPTIDE AND N-GLYCOPEPTIDE SYNTHESES Chemischer Informationsdienst. 15. DOI: 10.1002/Chin.198402318  0.487
1984 Kunz H, Waldmann H. The Allyl Group as Mildly and Selectively Removable Carboxy-Protecting Group for the Synthesis of LabileO-Glycopeptides Angewandte Chemie International Edition in English. 23: 71-72. DOI: 10.1002/Anie.198400711  0.472
1984 Kunz H, Waldmann H. Die Allylgruppe als mild und selektiv abspaltbare Carboxy-Schutzgruppe zur Synthese empfindlicherO-Glycopeptide Angewandte Chemie. 96: 49-50. DOI: 10.1002/Ange.19840960108  0.431
1983 Waldmann H, Kunz H. Allylester als selektiv abspaltbare Carboxyschutzgruppen in der Peptid- undN-Glycopeptidsynthese Liebigs Annalen Der Chemie. 1983: 1712-1725. DOI: 10.1002/Jlac.198319831007  0.484
1983 KUNZ H, WALDMANN H. ChemInform Abstract: 1,3-DITHIAN-2-YLMETHYL ESTER AS INTERMEDIATE PROTECTIVE GROUPS FOR CARBOXYL FUNCTION IN PEPTIDE SYNTHESIS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198315335  0.426
1983 Kunz H, Waldmann H. 1,3-Dithian-2-yl Methyl Ester as Two-Step Protecting Group for the Carboxy Function in Peptide Synthesis Angewandte Chemie International Edition in English. 22: 62-62. DOI: 10.1002/Anie.198300621  0.489
1983 Kunz H, Waldmann H. 1,3‐Dithian‐2‐yl‐methylester als Zweistufen‐Schutzgruppe für die Carboxyfunktion bei der Peptidsynthese Angewandte Chemie. 95: 47-48. DOI: 10.1002/Ange.19830950108  0.4
Low-probability matches (unlikely to be authored by this person)
1994 Waldmann H, Schmidt G, Jansen M, Geb J. Asymmetric steering of the Pictet-Spengler reaction by means of amino acid esters as chiral auxiliary groups Tetrahedron. 50: 11865-11884. DOI: 10.1016/S0040-4020(01)89301-7  0.3
1989 Waldmann H, Dräger M. On the enhancement of stereoselection by cooperation between chiral auxiliaries. Asymmetric diels-alder reactions with fumaric acid bis ((S)-proline benzyl ester) amide Tetrahedron Letters. 30: 4227-4230. DOI: 10.1016/S0040-4039(01)80696-1  0.3
2010 Rose R, Erdmann S, Bovens S, Wolf A, Rose M, Hennig S, Waldmann H, Ottmann C. Cover Picture: Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions (Angew. Chem. Int. Ed. 24/2010) Angewandte Chemie International Edition. 49: 3991-3991. DOI: 10.1002/Anie.201002255  0.3
2007 Rauh D, Waldmann H. Linking chemistry and biology for the study of protein function Angewandte Chemie - International Edition. 46: 826-829. PMID 17195266 DOI: 10.1002/Anie.200602979  0.299
2010 Wu Y, Oesterlin LK, Tan K, Waldmann H, Alexandrov K, Goody RS. Erratum: Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes Nature Chemical Biology. 6: 630-630. DOI: 10.1038/Nchembio0810-630B  0.299
1998 Sauerbrei B, Jungmann V, Waldmann H. An Enzyme-Labile Linker Group for Organic Syntheses on Solid Supports. Angewandte Chemie (International Ed. in English). 37: 1143-1146. PMID 29711024 DOI: 10.1002/(Sici)1521-3773(19980504)37:8<1143::Aid-Anie1143>3.0.Co;2-E  0.299
2001 Rak A, Reents R, Pylypenko O, Niculae A, Sidorovitch V, Thomä NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K. Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase Journal of Structural Biology. 136: 158-161. PMID 11886217 DOI: 10.1006/Jsbi.2001.4433  0.299
2012 Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 119: 1032-5. PMID 22144181 DOI: 10.1182/Blood-2011-06-358960  0.299
2016 Schürmann M, Janning P, Ziegler S, Waldmann H. Small-Molecule Target Engagement in Cells. Cell Chemical Biology. PMID 27049669 DOI: 10.1016/J.Chembiol.2016.03.008  0.299
1991 Waldmann H. Aminosäureester als chirale Hilfsgruppen bei Barbier-Reaktionen in wäßriger Lösung Liebigs Annalen Der Chemie. 1991: 1317-1322. DOI: 10.1002/Jlac.1991199101226  0.298
2013 Dakas PY, Parga JA, Höing S, Schöler HR, Sterneckert J, Kumar K, Waldmann H. Discovery of neuritogenic compound classes inspired by natural products. Angewandte Chemie (International Ed. in English). 52: 9576-81. PMID 23733315 DOI: 10.1002/Anie.201302045  0.297
1996 Waldmann H, Heuser A, Schulze S. Selective enzymatic removal of protecting groups: The phenylacetamide as amino protecting group in phosphopeptide synthesis Tetrahedron Letters. 37: 8725-8728. DOI: 10.1016/S0040-4039(96)02041-2  0.297
2007 Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer C, Breinbauer R, Szedlacsek S, Waldmann H. Eine Mikroarray-Strategie zur Untersuchung der Substratspezifitäten von Protein-Tyrosin-Phosphatasen Angewandte Chemie. 119: 7844-7847. DOI: 10.1002/Ange.200701601  0.297
2008 Jonkheijm P, Weinrich D, Schröder H, Niemeyer C, Waldmann H. Cover Picture: Chemical Strategies for Generating Protein Biochips (Angew. Chem. Int. Ed. 50/2008) Angewandte Chemie International Edition. 47: 9575-9575. DOI: 10.1002/Anie.200890256  0.297
2004 Müller O, Gourzoulidou E, Carpintero M, Karaguni IM, Langerak A, Herrmann C, Möröy T, Klein-Hitpass L, Waldmann H. Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening. Angewandte Chemie (International Ed. in English). 43: 450-4. PMID 14735532 DOI: 10.1002/Anie.200352587  0.296
2004 Huttenloch O, Laxman E, Waldmann H. Solid-phase development of chiral phosphoramidite ligands for enantioselective conjugate addition reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 4767-80. PMID 12561117 DOI: 10.1002/1521-3765(20021018)8:20<4767::Aid-Chem4767>3.0.Co;2-O  0.296
2014 Stieber F, Grether U, Waldmann H. An oxidation-labile traceless linker for solid-phase synthesis. Angewandte Chemie (International Ed. in English). 38: 1073-7. PMID 25138498 DOI: 10.1002/(Sici)1521-3773(19990419)38:8<1073::Aid-Anie1073>3.0.Co;2-Y  0.296
2020 Schneidewind T, Brause A, Pahl A, Burhop A, Mejuch T, Sievers S, Waldmann H, Ziegler S. Morphological profiling enables the identification of common mode of action for small molecules with different targets. Chembiochem : a European Journal of Chemical Biology. PMID 32618075 DOI: 10.1002/Cbic.202000381  0.296
2001 Jeyaraj DA, Waldmann H. Synthesis of nucleopeptides by an enzyme labile urethane protecting group Tetrahedron Letters. 42: 835-837. DOI: 10.1016/S0040-4039(00)02121-3  0.296
2005 Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M, Kuhlmann J, Waldmann H, Wittinghofer A, Bastiaens PI. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (New York, N.Y.). 307: 1746-52. PMID 15705808 DOI: 10.1126/Science.1105654  0.296
2009 Tannert R, Hu TS, Arndt HD, Waldmann H. Solid-phase based total synthesis of Jasplakinolide by ring-closing metathesis Chemical Communications. 1493-1495. PMID 19277367 DOI: 10.1039/B900342H  0.296
2004 Heinemann I, Völkert M, Waldmann H. Synthesis of lipidated peptides. Methods in Molecular Biology (Clifton, N.J.). 283: 221-32. PMID 15197314 DOI: 10.1385/1-59259-813-7:221  0.296
2003 Huttenloch O, Laxman E, Waldmann H. Combinatorial development of chiral phosphoramidite-ligands for enantioselective conjugate addition reactions. Chemical Communications (Cambridge, England). 673-5. PMID 12119669 DOI: 10.1039/B200454B  0.296
2018 Lee Y, Kumar K, Waldmann H. Ligandengesteuerte divergente Synthese von carbo- und heterocyclischen Ringsystemen Angewandte Chemie. 130: 5308-5322. DOI: 10.1002/Ange.201710247  0.296
1990 Waldmann H. Prolin-benzylester als chirale Hilfsgruppen in asymmetrischen 1,3-dipolaren Cycloadditionen mit Nitriloxiden Liebigs Annalen Der Chemie. 1990: 1013-1017. DOI: 10.1002/Jlac.1990199001183  0.295
2010 Waldmann H. Protein Targeting with Small Molecules. Chemical Biology Techniques and Applications. Herausgegeben von Hiroyuki Osada. Angewandte Chemie. 122: 2522-2522. DOI: 10.1002/Ange.201000606  0.295
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