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Andrew Kyle Lewis - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Protein dynamics
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19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lewis AK, Harthorn A, Johnson SM, Lobb RR, Hackel BJ. Engineered protein-small molecule conjugates empower selective enzyme inhibition. Cell Chemical Biology. PMID 34363759 DOI: 10.1016/j.chembiol.2021.07.013  0.693
2018 Beaven AH, Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. Computational Studies of Alpha-Synuclein Fibril Formation and Stability Biophysical Journal. 114: 230a. DOI: 10.1016/J.Bpj.2017.11.1278  0.663
2017 Vunnam N, Campbell-Bezat CK, Lewis AK, Sachs JN. Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer. Biophysical Journal. 113: 381-392. PMID 28746849 DOI: 10.1016/J.Bpj.2017.05.038  0.692
2017 Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. Minimal nucleation state of alpha-Synuclein is stabilized by dynamic threonine-water networks. Acs Chemical Neuroscience. PMID 28677385 DOI: 10.1021/Acschemneuro.7B00171  0.703
2017 Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors. Slas Discovery. 2472555217706478. PMID 28530838 DOI: 10.1177/2472555217706478  0.697
2017 Valley CC, Lewis AK, Sachs JN. Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors. Biochimica Et Biophysica Acta. PMID 28089689 DOI: 10.1016/J.Bbamem.2017.01.016  0.806
2016 Lewis AK, Valley CC, Peery SL, Brummel B, Braun AR, Karim C, Sachs JN. Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. Journal of Molecular Biology. PMID 27720987 DOI: 10.1016/J.Jmb.2016.10.001  0.789
2016 Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, et al. Oxidation increases the strength of the methionine-aromatic interaction. Nature Chemical Biology. PMID 27547920 DOI: 10.1038/Nchembio.2159  0.766
2016 Hung Lo C, Lewis A, Schaaf T, Bawaskar P, Vunnam N, Peterson K, Thomas D, Sachs J. Manipulations of the TNF-Receptor Affinity and Oligomerization Characterized by Fluorescence Lifetime Measurements Biophysical Journal. 110: 490a. DOI: 10.1016/J.Bpj.2015.11.2618  0.718
2016 Senkow TL, Lewis AK, Sachs JN. Investigating the Role of Transmembrane Domain Cysteine Residues in the Organization of TNF Receptors Biophysical Journal. 110: 227a. DOI: 10.1016/J.Bpj.2015.11.1257  0.685
2015 Senkow TL, Lewis AK, McCarthy MR, Her C, Thomas DD, Sachs JN. Methionine-Aromatic Interactions in Calmodulin: A Replica Exchange MD and EPR Spectroscopy Study Biophysical Journal. 108: 213a-214a. DOI: 10.1016/J.Bpj.2014.11.1180  0.605
2014 Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN. Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation. Biophysical Journal. 106: L21-4. PMID 24655519 DOI: 10.1016/J.Bpj.2014.01.044  0.78
2014 Lewis AK, Valley CC, Braun AR, Sachs JN. Quantitative Analysis of Ligand-Induced Supramolecular Clustering of Death Receptor 5 in Jurkat Cells Biophysical Journal. 106: 715a. DOI: 10.1016/J.Bpj.2013.11.3953  0.804
2014 Lewis AK, Sachs JN. Oxidative Stress Modulates Bioactivity of Lymphotoxin, but not TNF, Through Site-Specific Oxidation of Methionine Residues Biophysical Journal. 106: 251a-252a. DOI: 10.1016/J.Bpj.2013.11.1481  0.698
2012 Valley CC, Cembran A, Perlmutter JD, Lewis AK, Labello NP, Gao J, Sachs JN. The methionine-aromatic motif plays a unique role in stabilizing protein structure. The Journal of Biological Chemistry. 287: 34979-91. PMID 22859300 DOI: 10.1074/Jbc.M112.374504  0.77
2012 Lewis AK, Valley CC, Sachs JN. TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant. Biochemistry. 51: 6545-55. PMID 22799488 DOI: 10.1021/Bi3006626  0.817
2012 Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. The Journal of Biological Chemistry. 287: 21265-78. PMID 22496450 DOI: 10.1074/Jbc.M111.306480  0.77
2012 Valley CC, Lewis AK, Mudaliar D, Sachs JN. Signaling in the Tumor Necrosis Factor Superfamily is Driven by Formation of Receptor Networks: Unraveling the Structural and Dynamic Paradigm Biophysical Journal. 102: 430a. DOI: 10.1016/J.Bpj.2011.11.2355  0.815
2012 Lewis AK. Analysis of Conformational Dynamics Associated with TNFR1 Signaling by Live-Cell FRET and Computational Modeling Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1381  0.538
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