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Shiyu Chen - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Chen S, Goncin U, Zhu J, Su SP, Czyzyk TA, Miller CO, Kashfi Sadabad R, Bogyo M. A caspase-1-cathepsin AND-gate probe for selective imaging of inflammasome activation. Biorxiv : the Preprint Server For Biology. PMID 40501809 DOI: 10.1101/2025.05.27.656501  0.421
2025 Upadhyay T, Woods EC, Dela Ahator S, Julin K, Faucher FF, Uddin MJ, Hollander MJ, Pedowitz NJ, Abegg D, Hammond I, Eke IE, Wang S, Chen S, Bennett JM, Jo J, et al. Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation. Nature Communications. 16: 5046. PMID 40447595 DOI: 10.1038/s41467-025-60367-3  0.506
2024 Bogyo M, Upadhyay T, Woods E, Ahator S, Julin K, Faucher F, Hollander M, Pedowitz N, Abegg D, Hammond I, Eke I, Wang S, Chen S, Bennett J, Jo J, et al. Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation. Research Square. PMID 39711551 DOI: 10.21203/rs.3.rs-5494070/v1  0.641
2024 Zhang H, Xing Y, Yang Y, Tang B, Zong Z, Li J, Zang Y, Bogyo M, Lu X, Chen S. DNA-Encoded Noncanonical Substrate Library for Protease Profiling. Chembiochem : a European Journal of Chemical Biology. e202400559. PMID 39299917 DOI: 10.1002/cbic.202400559  0.557
2024 Lan T, Peng C, Yao X, Chan RST, Wei T, Rupanya A, Radakovic A, Wang S, Chen S, Lovell S, Snyder SA, Bogyo M, Dickinson BC. Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display. Journal of the American Chemical Society. PMID 39136646 DOI: 10.1021/jacs.4c07851  0.71
2024 Xing Y, Zhang H, Wang Y, Zong Z, Bogyo M, Chen S. DNA encoded peptide library for SARS-CoV-2 3CL protease covalent inhibitor discovery and profiling. Rsc Chemical Biology. 5: 691-702. PMID 38966676 DOI: 10.1039/d4cb00097h  0.659
2024 Hadzima M, Faucher FF, Blažková K, Yim JJ, Guerra M, Chen S, Woods EC, Park KW, Šácha P, Šubr V, Kostka L, Etrych T, Majer P, Konvalinka J, Bogyo M. Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases. Acs Sensors. PMID 38941307 DOI: 10.1021/acssensors.4c00912  0.465
2024 Hadzima M, Faucher F, Blažková K, Yim JJ, Guerra M, Chen S, Woods EC, Park KW, Šácha P, Šubr V, Kostka L, Etrych T, Majer P, Konvalinka J, Bogyo M. Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases. Biorxiv : the Preprint Server For Biology. PMID 38766164 DOI: 10.1101/2024.05.06.592849  0.465
2021 Zhang H, Chen S. Cyclic peptide drugs approved in the last two decades (2001-2021). Rsc Chemical Biology. 3: 18-31. PMID 35128405 DOI: 10.1039/d1cb00154j  0.476
2020 Chen S, Lovell S, Lee S, Fellner M, Mace PD, Bogyo M. Identification of highly selective covalent inhibitors by phage display. Nature Biotechnology. PMID 33199876 DOI: 10.1038/s41587-020-0733-7  0.602
2019 Chen S, Yim JJ, Bogyo M. Synthetic and biological approaches to map substrate specificities of proteases. Biological Chemistry. PMID 31639098 DOI: 10.1515/Hsz-2019-0332  0.571
2015 Baeriswyl V, Calzavarini S, Chen S, Zorzi A, Bologna L, Angelillo-Scherrer A, Heinis C. A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation. Acs Chemical Biology. 10: 1861-70. PMID 25989088 DOI: 10.1021/acschembio.5b00103  0.685
2015 Chen S, Heinis C. Phage selection of bicyclic peptides based on two disulfide bridges. Methods in Molecular Biology (Clifton, N.J.). 1248: 119-37. PMID 25616330 DOI: 10.1007/978-1-4939-2020-4_9  0.733
2014 Chen S, Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C. Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nature Chemistry. 6: 1009-16. PMID 25343607 DOI: 10.1038/Nchem.2043  0.688
2014 Bellotto S, Chen S, Rentero Rebollo I, Wegner HA, Heinis C. Phage selection of photoswitchable peptide ligands. Journal of the American Chemical Society. 136: 5880-3. PMID 24702159 DOI: 10.1021/ja501861m  0.699
2014 Chen S, Bertoldo D, Angelini A, Pojer F, Heinis C. Peptide ligands stabilized by small molecules. Angewandte Chemie (International Ed. in English). 53: 1602-6. PMID 24453110 DOI: 10.1002/anie.201309459  0.723
2014 Chen S, Touati J, Heinis C. Tracking chemical reactions on the surface of filamentous phage using mass spectrometry. Chemical Communications (Cambridge, England). 50: 5267-9. PMID 24291807 DOI: 10.1039/c3cc47496h  0.646
2013 Chen S, Gfeller D, Buth SA, Michielin O, Leiman PG, Heinis C. Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids. Chembiochem : a European Journal of Chemical Biology. 14: 1316-22. PMID 23828687 DOI: 10.1002/Cbic.201300228  0.697
2013 Lee B, Chen S, Heinis C, Scopelliti R, Severin K. Pattern-based sensing of peptides and aminoglycosides with a single molecular probe. Organic Letters. 15: 3456-9. PMID 23796050 DOI: 10.1021/Ol401495C  0.657
2013 Chen S, Rentero Rebollo I, Buth SA, Morales-Sanfrutos J, Touati J, Leiman PG, Heinis C. Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries. Journal of the American Chemical Society. 135: 6562-9. PMID 23560397 DOI: 10.1021/Ja400461H  0.71
2012 Angelini A, Morales-Sanfrutos J, Diderich P, Chen S, Heinis C. Bicyclization and tethering to albumin yields long-acting peptide antagonists. Journal of Medicinal Chemistry. 55: 10187-97. PMID 23088498 DOI: 10.1021/jm301276e  0.711
2012 Chen S, Morales-Sanfrutos J, Angelini A, Cutting B, Heinis C. Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides. Chembiochem : a European Journal of Chemical Biology. 13: 1032-8. PMID 22492661 DOI: 10.1002/cbic.201200049  0.727
2012 Baeriswyl V, Rapley H, Pollaro L, Stace C, Teufel D, Walker E, Chen S, Winter G, Tite J, Heinis C. Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. Chemmedchem. 7: 1173-6. PMID 22492508 DOI: 10.1002/cmdc.201200071  0.69
2012 Angelini A, Cendron L, Chen S, Touati J, Winter G, Zanotti G, Heinis C. Bicyclic peptide inhibitor reveals large contact interface with a protease target. Acs Chemical Biology. 7: 817-21. PMID 22304751 DOI: 10.1021/cb200478t  0.752
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