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Brandon T. Ruotolo - Publications

Affiliations: 
Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
ion mobility-mass spectrometry (IM-MS), to determine the composition, size, and topological organization of protein assemblies
Website:
https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=bruotolo

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Polasky DA, Dixit SM, Keating MF, Gadkari VV, Andrews PC, Ruotolo BT. Pervasive Charge Solvation Permeates Native-like Protein Ions and Dramatically Influences Top-down Sequencing Data. Journal of the American Chemical Society. PMID 32203657 DOI: 10.1021/jacs.0c01076  1
2020 Dixit SM, Richardson K, Langridge D, Giles K, Ruotolo BT. A Novel Ion Pseudo-trapping Phenomenon within Traveling Wave Ion Guides. Journal of the American Society For Mass Spectrometry. PMID 32134265 DOI: 10.1021/jasms.9b00095  1
2019 Kang J, Halseth T, Vallejo D, Najafabadi ZI, Sen KI, Ford M, Ruotolo BT, Schwendeman A. Assessment of biosimilarity under native and heat-stressed conditions: rituximab, bevacizumab, and trastuzumab originators and biosimilars. Analytical and Bioanalytical Chemistry. PMID 31853605 DOI: 10.1007/s00216-019-02298-9  0.56
2019 Kang J, Yeop Kim S, Vallejo D, Hageman TS, White DR, Benet A, Coghlan J, Ilker Sen K, Ford M, Saveliev S, Tolbert TJ, Weis DD, Schwendeman SP, Ruotolo BT, Schwendeman A. Multifaceted assessment of rituximab biosimilarity: The impact of glycan microheterogeneity on Fc function. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 31841688 DOI: 10.1016/j.ejpb.2019.12.003  0.56
2019 Fantin SM, Parson KF, Niu S, Liu J, Polasky DA, Dixit SM, Ferguson-Miller SM, Ruotolo BT. Collision Induced Unfolding Classifies Ligands Bound to the Integral Membrane Translocator Protein (TSPO). Analytical Chemistry. PMID 31743004 DOI: 10.1021/acs.analchem.9b03208  1
2019 Meinen BA, Gadkari VV, Stull F, Ruotolo BT, Bardwell JCA. SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 31659041 DOI: 10.1073/pnas.1913316116  0.76
2019 Polasky DA, Dixit SM, Vallejo DD, Kulju KD, Ruotolo BT. An Algorithm for Building Multi-State Classifiers Based on Collision Induced Unfolding Data. Analytical Chemistry. PMID 31310505 DOI: 10.1021/acs.analchem.9b02650  1
2019 Vallejo DD, Polasky DA, Kurulugama RT, Eschweiler JD, Fjeldsted JC, Ruotolo BT. A Modified Drift Tube Ion Mobility-Mass Spectrometer for Charge-Multiplexed Collision-Induced Unfolding. Analytical Chemistry. PMID 31194508 DOI: 10.1021/acs.analchem.9b00427  0.96
2019 Tian Y, Huang L, Ruotolo BT, Wang N. Hydrogen/deuterium exchange-mass spectrometry analysis of high concentration biotherapeutics: application to phase-separated antibody formulations. Mabs. 1-10. PMID 30890021 DOI: 10.1080/19420862.2019.1589850  0.92
2019 Wang H, Eschweiler J, Cui W, Zhang H, Frieden C, Ruotolo BT, Gross ML. Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation, and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E Oligomers. Journal of the American Society For Mass Spectrometry. PMID 30887458 DOI: 10.1007/s13361-019-02148-z  0.64
2019 Dixit SM, Ruotolo BT. A Semi-Empirical Framework for Interpreting Traveling Wave Ion Mobility Arrival Time Distributions. Journal of the American Society For Mass Spectrometry. PMID 30815838 DOI: 10.1007/s13361-019-02133-6  1
2019 Polasky DA, Dixit SM, Fantin SM, Ruotolo BT. CIUSuite 2: Next-Generation Software for the Analysis of Gas-phase Protein Unfolding Data. Analytical Chemistry. PMID 30668913 DOI: 10.1021/acs.analchem.8b05762  1
2018 Tian Y, Lippens JL, Netirojjanakul C, Campuzano IDG, Ruotolo BT. Quantitative collision-induced unfolding differentiates model antibody-drug conjugates. Protein Science : a Publication of the Protein Society. PMID 30499138 DOI: 10.1002/pro.3560  0.92
2018 Rabuck-Gibbons JN, Lodge JM, Mapp AK, Ruotolo BT. Collision-Induced Unfolding Reveals Unique Fingerprints for Remote Protein Interaction Sites in the KIX Regulation Domain. Journal of the American Society For Mass Spectrometry. PMID 30136215 DOI: 10.1007/s13361-018-2043-6  0.76
2018 Kang J, Pisupati K, Benet A, Ruotolo BT, Schwendeman SP, Schwendeman A. Infliximab Biosimilars in the Age of Personalized Medicine. Trends in Biotechnology. PMID 29861288 DOI: 10.1016/j.tibtech.2018.05.002  0.56
2018 Tian Y, Ruotolo BT. The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies. The Analyst. PMID 29736508 DOI: 10.1039/c8an00295a  0.92
2018 Eschweiler JD, Farrugia MA, Dixit SM, Hausinger RP, Ruotolo BT. A Structural Model of the Urease Activation Complex Derived from Ion Mobility-Mass Spectrometry and Integrative Modeling. Structure (London, England : 1993). PMID 29576318 DOI: 10.1016/j.str.2018.03.001  1
2018 Polasky DA, Lermyte F, Nshanian M, Sobott F, Andrews PC, Loo J, Ruotolo BT. Fixed-charge Trimethyl Pyrilium Modification Enables Enhanced Top-down Mass Spectrometry Sequencing of Intact Protein Complexes. Analytical Chemistry. PMID 29360341 DOI: 10.1021/acs.analchem.7b04806  0.96
2017 Avtonomov DM, Polasky DA, Ruotolo BT, Nesvizhskii AI. IMTBX and Grppr: Software for Top-Down Proteomics Utilizing Ion Mobility-Mass Spectrometry. Analytical Chemistry. PMID 29278491 DOI: 10.1021/acs.analchem.7b04999  0.96
2017 Dixit SM, Polasky DA, Ruotolo BT. Collision induced unfolding of isolated proteins in the gas phase: past, present, and future. Current Opinion in Chemical Biology. 42: 93-100. PMID 29207278 DOI: 10.1016/j.cbpa.2017.11.010  1
2017 Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease. Chemmedchem. 12: 1828-1838. PMID 28990338 DOI: 10.1002/cmdc.201700456  0.56
2017 Niu S, Kim BC, Fierke CA, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1. International Journal of Mass Spectrometry. 420: 9-15. PMID 28983190 DOI: 10.1016/j.ijms.2016.12.017  0.64
2017 Pisupati K, Benet A, Tian Y, Okbazghi S, Kang J, Ford M, Saveliev S, Sen KI, Carlson E, Tolbert TJ, Ruotolo BT, Schwendeman SP, Schwendeman A. Biosimilarity under stress: a forced degradation study of Remicade® and Remsima™. Mabs. 0. PMID 28787231 DOI: 10.1080/19420862.2017.1347741  0.92
2017 Badieyan S, Sciore A, Eschweiler J, Koldewey P, Cristie-David AS, Ruotolo BT, Bardwell JCA, Su M, Marsh N. Symmetry-directed Self-assembly of a Tetrahedral Protein Cage Mediated by De Novo-designed Coiled Coils. Chembiochem : a European Journal of Chemical Biology. PMID 28763578 DOI: 10.1002/cbic.201700406  0.64
2017 Ferguson KL, Eschweiler JD, Ruotolo BT, Marsh ENG. Evidence for a 1,3-Dipolar Cyclo-addition Mechanism in the Decarboxylation of Phenylacrylic Acids Catalyzed by Ferulic Acid Decarboxylase. Journal of the American Chemical Society. PMID 28753302 DOI: 10.1021/jacs.7b05060  0.88
2017 Eschweiler JD, Frank AT, Ruotolo BT. Coming to Grips with Ambiguity: Ion Mobility-Mass Spectrometry for Protein Quaternary Structure Assignment. Journal of the American Society For Mass Spectrometry. PMID 28752478 DOI: 10.1007/s13361-017-1757-1  0.88
2017 Haynes SE, Polasky DA, Dixit SM, Majmudar JD, Neeson K, Ruotolo BT, Martin BR. Variable-Velocity Traveling-Wave Ion Mobility Separation Enhancing Peak Capacity for Data-Independent Acquisition Proteomics. Analytical Chemistry. PMID 28471653 DOI: 10.1021/acs.analchem.7b00112  1
2017 Pisupati K, Tian Y, Okbazghi S, Benet A, Ackermann R, Ford M, Saveliev SV, Hosfield CM, Urh M, Carlson E, Becker C, Tolbert TJ, Schwendeman SP, Ruotolo BT, Schwendeman A. A Multidimensional Analytical Comparison of Remicade and the Biosimilar Remsima. Analytical Chemistry. PMID 28365979 DOI: 10.1021/acs.analchem.6b04436  0.92
2017 Eschweiler JD, Kerr R, Rabuck-Gibbons J, Ruotolo BT. Sizing Up Protein-Ligand Complexes: The Rise of Structural Mass Spectrometry Approaches in the Pharmaceutical Sciences. Annual Review of Analytical Chemistry (Palo Alto, Calif.). PMID 28301749 DOI: 10.1146/annurev-anchem-061516-045414  0.88
2017 Soper-Hopper MT, Eschweiler JD, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals a Dipeptide That Acts as a Molecular Chaperone for Amyloid β. Acs Chemical Biology. PMID 28240851 DOI: 10.1021/acschembio.7b00045  0.88
2017 Won SJ, Eschweiler JD, Majmudar JD, Chong FS, Hwang SY, Ruotolo BT, Martin BR. Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2. Acs Medicinal Chemistry Letters. 8: 215-220. PMID 28197315 DOI: 10.1021/acsmedchemlett.6b00441  0.88
2017 Lee HJ, Korshavn KJ, Nam Y, Kang J, Paul TJ, Kerr RA, Youn IS, Ozbil M, Kim KS, Ruotolo BT, Prabhakar R, Ramamoorthy A, Lim MH. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 2706-2715. PMID 28004889 DOI: 10.1002/chem.201605401  0.56
2016 Eschweiler JD, Martini RM, Ruotolo BT. Chemical probes and engineered constructs reveal a detailed unfolding mechanism for a solvent-free multi-domain protein. Journal of the American Chemical Society. PMID 27959526 DOI: 10.1021/jacs.6b11678  0.88
2016 Beck MW, Derrick JS, Kerr RA, Oh SB, Cho WJ, Lee SJ, Ji Y, Han J, Tehrani ZA, Suh N, Kim S, Larsen SD, Kim KS, Lee JY, Ruotolo BT, et al. Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease. Nature Communications. 7: 13115. PMID 27734843 DOI: 10.1038/ncomms13115  1
2016 Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN. Flexible, symmetry-directed approach to assembling protein cages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432965 DOI: 10.1073/pnas.1606013113  0.88
2016 Derrick JS, Kerr RA, Korshavn KJ, McLane MJ, Kang J, Nam E, Ramamoorthy A, Ruotolo BT, Lim MH. Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease. Inorganic Chemistry. 55: 5000-13. PMID 27119456 DOI: 10.1021/acs.inorgchem.6b00525  0.56
2016 Samulak BM, Niu S, Andrews PC, Ruotolo BT. Ion Mobility-Mass Spectrometry Analysis of Crosslinked Intact Multiprotein Complexes: Enhanced Gas-phase Stabilities and Altered Dissociation Pathways. Analytical Chemistry. PMID 27078797 DOI: 10.1021/acs.analchem.6b00518  1
2016 Zhang Y, Halder S, Kerr RA, Parrell D, Ruotolo B, Kroos L. Complex Formed between Intramembrane Metalloprotease SpoIVFB and Its Substrate Pro-σK. The Journal of Biological Chemistry. PMID 26953342 DOI: 10.1074/jbc.M116.715508  0.56
2016 Lee HJ, Kerr RA, Korshavn KJ, Lee J, Kang J, Ramamoorthy A, Ruotolo BT, Lim MH. Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation Inorganic Chemistry Frontiers. 3: 381-392. DOI: 10.1039/c5qi00219b  1
2015 Beck MW, Oh SB, Kerr RA, Lee HJ, Kim SH, Kim S, Jang M, Ruotolo BT, Lee JY, Lim MH. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease. Chemical Science. 6: 1879-1886. PMID 28706643 DOI: 10.1039/c4sc03239j  0.56
2015 Derrick JS, Kerr RA, Nam Y, Oh SB, Lee HJ, Earnest KG, Suh N, Peck KL, Ozbil M, Korshavn KJ, Ramamoorthy A, Prabhakar R, Merino EJ, Shearer J, Lee JY, ... Ruotolo BT, et al. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms. Journal of the American Chemical Society. 137: 14785-97. PMID 26575890 DOI: 10.1021/jacs.5b10043  0.56
2015 Eschweiler JD, Rabuck-Gibbons JN, Tian Y, Ruotolo BT. CIUSuite: A Quantitative Analysis Package for Collision Induced Unfolding Measurements of Gas-Phase Protein Ions. Analytical Chemistry. PMID 26489593 DOI: 10.1021/acs.analchem.5b03292  1
2015 Tian Y, Han L, Buckner AC, Ruotolo BT. Collision Induced Unfolding of Intact Antibodies: Rapid Characterization of Disulfide Bonding Patterns, Glycosylation, and Structures. Analytical Chemistry. PMID 26471104 DOI: 10.1021/acs.analchem.5b03291  1
2015 Bornschein RE, Ruotolo BT. Ion mobility-mass spectrometry of charge-reduced protein complexes reveals general trends in the collisional ejection of compact subunits. The Analyst. 140: 7020-9. PMID 26331159 DOI: 10.1039/c5an01242b  1
2015 Bornschein RE, Niu S, Eschweiler J, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals Highly-Compact Intermediates in the Collision Induced Dissociation of Charge-Reduced Protein Complexes. Journal of the American Society For Mass Spectrometry. PMID 26323618 DOI: 10.1007/s13361-015-1250-7  1
2015 Han L, Ruotolo BT. Ion Mobility-Mass Spectrometry Differentiates Protein Quaternary Structures Formed in Solution and in Electrospray Droplets. Analytical Chemistry. PMID 26075825 DOI: 10.1021/acs.analchem.5b01010  1
2015 Niu S, Ruotolo BT. Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding. Protein Science : a Publication of the Protein Society. PMID 25970849 DOI: 10.1002/pro.2699  1
2015 Barran P, Ruotolo B. Ion Mobility Mass Spectrometry Analyst. 140: 6772-6774. DOI: 10.1039/c5an90076j  1
2015 Beck MW, Oh SB, Kerr RA, Lee HJ, Kim SH, Kim S, Jang M, Ruotolo BT, Lee JY, Lim MH. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease Chemical Science. 6: 1879-1886. DOI: 10.1039/c4sc03239j  1
2014 Zhong Y, Han L, Ruotolo BT. Collisional and Coulombic unfolding of gas-phase proteins: high correlation to their domain structures in solution. Angewandte Chemie (International Ed. in English). 53: 9209-12. PMID 24990104 DOI: 10.1002/anie.201403784  1
2013 Zhong Y, Feng J, Ruotolo BT. Robotically assisted titration coupled to ion mobility-mass spectrometry reveals the interface structures and analysis parameters critical for multiprotein topology mapping. Analytical Chemistry. 85: 11360-8. PMID 24164205 DOI: 10.1021/ac402276k  1
2013 Niu S, Rabuck JN, Ruotolo BT. Ion mobility-mass spectrometry of intact protein--ligand complexes for pharmaceutical drug discovery and development. Current Opinion in Chemical Biology. 17: 809-17. PMID 23856053 DOI: 10.1016/j.cbpa.2013.06.019  1
2013 Rabuck JN, Hyung SJ, Ko KS, Fox CC, Soellner MB, Ruotolo BT. Activation state-selective kinase inhibitor assay based on ion mobility-mass spectrometry. Analytical Chemistry. 85: 6995-7002. PMID 23845095 DOI: 10.1021/ac4012655  1
2013 Han L, Ruotolo BT. Hofmeister salts recover a misfolded multiprotein complex for subsequent structural measurements in the gas phase. Angewandte Chemie (International Ed. in English). 52: 8329-32. PMID 23818426 DOI: 10.1002/anie.201301893  1
2013 Farrugia MA, Han L, Zhong Y, Boer JL, Ruotolo BT, Hausinger RP. Analysis of a soluble (UreD:UreF:UreG)2 accessory protein complex and its interactions with Klebsiella aerogenes urease by mass spectrometry. Journal of the American Society For Mass Spectrometry. 24: 1328-37. PMID 23797863 DOI: 10.1007/s13361-013-0677-y  1
2013 Han L, Hyung SJ, Ruotolo BT. Dramatically stabilizing multiprotein complex structure in the absence of bulk water using tuned Hofmeister salts. Faraday Discussions. 160: 371-88; discussion 3. PMID 23795511 DOI: 10.1039/c2fd20099f  1
2013 Soper MT, DeToma AS, Hyung SJ, Lim MH, Ruotolo BT. Amyloid-β-neuropeptide interactions assessed by ion mobility-mass spectrometry. Physical Chemistry Chemical Physics : Pccp. 15: 8952-61. PMID 23612608 DOI: 10.1039/c3cp50721a  1
2013 Politis A, Park AY, Hall Z, Ruotolo BT, Robinson CV. Integrative modelling coupled with ion mobility mass spectrometry reveals structural features of the clamp loader in complex with single-stranded DNA binding protein. Journal of Molecular Biology. 425: 4790-801. PMID 23583780 DOI: 10.1016/j.jmb.2013.04.006  1
2013 Han L, Ruotolo BT. Traveling-wave Ion Mobility-Mass Spectrometry Reveals Additional Mechanistic Details in the Stabilization of Protein Complex Ions through Tuned Salt Additives. International Journal For Ion Mobility Spectrometry : Official Publication of the International Society For Ion Mobility Spectrometry. 16: 41-50. PMID 23539363 DOI: 10.1007/s12127-013-0121-9  1
2013 Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. Biochemistry. 52: 1903-12. PMID 23445400 DOI: 10.1021/bi400027y  0.56
2013 Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi JS, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proceedings of the National Academy of Sciences of the United States of America. 110: 3743-8. PMID 23426629 DOI: 10.1073/pnas.1220326110  0.56
2012 Pithadia AS, Kochi A, Soper MT, Beck MW, Liu Y, Lee S, DeToma AS, Ruotolo BT, Lim MH. Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species. Inorganic Chemistry. 51: 12959-67. PMID 23153071 DOI: 10.1021/ic302084g  1
2012 McLean JA, Ruotolo BT. 24th Sanibel Conference on mass spectrometry: Mass spectrometry technologies for structural biology. Journal of the American Society For Mass Spectrometry. 23: 2208-12. PMID 23055079 DOI: 10.1007/s13361-012-0494-8  1
2012 Hyung SJ, Ruotolo BT. Integrating mass spectrometry of intact protein complexes into structural proteomics. Proteomics. 12: 1547-64. PMID 22611037 DOI: 10.1002/pmic.201100520  1
2012 Han L, Hyung SJ, Ruotolo BT. Bound cations significantly stabilize the structure of multiprotein complexes in the gas phase. Angewandte Chemie (International Ed. in English). 51: 5692-5. PMID 22529039 DOI: 10.1002/anie.201109127  1
2012 He X, Park HM, Hyung SJ, DeToma AS, Kim C, Ruotolo BT, Lim MH. Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species. Dalton Transactions (Cambridge, England : 2003). 41: 6558-66. PMID 22437427 DOI: 10.1039/c2dt12207c  1
2012 Zhong Y, Hyung SJ, Ruotolo BT. Ion mobility-mass spectrometry for structural proteomics. Expert Review of Proteomics. 9: 47-58. PMID 22292823 DOI: 10.1586/epr.11.75  1
2012 Freeke J, Bush MF, Robinson CV, Ruotolo BT. Gas-phase protein assemblies: Unfolding landscapes and preserving native-like structures using noncovalent adducts Chemical Physics Letters. 524: 1-9. DOI: 10.1016/j.cplett.2011.11.014  1
2011 Bornschein RE, Hyung SJ, Ruotolo BT. Ion mobility-mass spectrometry reveals conformational changes in charge reduced multiprotein complexes. Journal of the American Society For Mass Spectrometry. 22: 1690-8. PMID 21952882 DOI: 10.1007/s13361-011-0204-y  1
2011 Benesch JL, Ruotolo BT. Mass spectrometry: come of age for structural and dynamical biology. Current Opinion in Structural Biology. 21: 641-9. PMID 21880480 DOI: 10.1016/j.sbi.2011.08.002  1
2011 Han L, Hyung SJ, Mayers JJ, Ruotolo BT. Bound anions differentially stabilize multiprotein complexes in the absence of bulk solvent. Journal of the American Chemical Society. 133: 11358-67. PMID 21675748 DOI: 10.1021/ja203527a  1
2011 Salamekh S, Brender JR, Hyung SJ, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A. A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. Journal of Molecular Biology. 410: 294-306. PMID 21616080 DOI: 10.1016/j.jmb.2011.05.015  0.56
2011 Zhong Y, Hyung SJ, Ruotolo BT. Characterizing the resolution and accuracy of a second-generation traveling-wave ion mobility separator for biomolecular ions. The Analyst. 136: 3534-41. PMID 21445388 DOI: 10.1039/c0an00987c  1
2011 Hogan CJ, Ruotolo BT, Robinson CV, Fernandez de la Mora J. Tandem differential mobility analysis-mass spectrometry reveals partial gas-phase collapse of the GroEL complex. The Journal of Physical Chemistry. B. 115: 3614-21. PMID 21395304 DOI: 10.1021/jp109172k  1
2010 Boeri Erba E, Ruotolo BT, Barsky D, Robinson CV. Ion mobility-mass spectrometry reveals the influence of subunit packing and charge on the dissociation of multiprotein complexes. Analytical Chemistry. 82: 9702-10. PMID 21053918 DOI: 10.1021/ac101778e  1
2010 Bush MF, Hall Z, Giles K, Hoyes J, Robinson CV, Ruotolo BT. Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology. Analytical Chemistry. 82: 9557-65. PMID 20979392 DOI: 10.1021/ac1022953  1
2010 Politis A, Park AY, Hyung SJ, Barsky D, Ruotolo BT, Robinson CV. Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes. Plos One. 5: e12080. PMID 20711472 DOI: 10.1371/journal.pone.0012080  1
2010 Pagel K, Hyung SJ, Ruotolo BT, Robinson CV. Alternate dissociation pathways identified in charge-reduced protein complex ions. Analytical Chemistry. 82: 5363-72. PMID 20481443 DOI: 10.1021/ac101121r  1
2010 Benesch JL, Ruotolo BT, Simmons DA, Barrera NP, Morgner N, Wang L, Saibil HR, Robinson CV. Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy. Journal of Structural Biology. 172: 161-8. PMID 20227505 DOI: 10.1016/j.jsb.2010.03.004  1
2010 Park AY, Jergic S, Politis A, Ruotolo BT, Hirshberg D, Jessop LL, Beck JL, Barsky D, O'Donnell M, Dixon NE, Robinson CV. A single subunit directs the assembly of the Escherichia coli DNA sliding clamp loader. Structure (London, England : 1993). 18: 285-92. PMID 20223211 DOI: 10.1016/j.str.2010.01.009  1
2010 Freeke J, Robinson CV, Ruotolo BT. Residual counter ions can stabilise a large protein complex in the gas phase International Journal of Mass Spectrometry. 298: 91-98. DOI: 10.1016/j.ijms.2009.08.001  1
2009 Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nature Chemistry. 1: 326-31. PMID 20703363 DOI: 10.1038/nchem.247  1
2009 Pukala TL, Ruotolo BT, Zhou M, Politis A, Stefanescu R, Leary JA, Robinson CV. Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements. Structure (London, England : 1993). 17: 1235-43. PMID 19748344 DOI: 10.1016/j.str.2009.07.013  1
2009 Leary JA, Schenauer MR, Stefanescu R, Andaya A, Ruotolo BT, Robinson CV, Thalassinos K, Scrivens JH, Sokabe M, Hershey JW. Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors. Journal of the American Society For Mass Spectrometry. 20: 1699-706. PMID 19564121 DOI: 10.1016/j.jasms.2009.05.003  1
2009 Hyung SJ, Robinson CV, Ruotolo BT. Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes. Chemistry & Biology. 16: 382-90. PMID 19389624 DOI: 10.1016/j.chembiol.2009.02.008  1
2009 Fidalgo LM, Whyte G, Ruotolo BT, Benesch JL, Stengel F, Abell C, Robinson CV, Huck WT. Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. Angewandte Chemie (International Ed. in English). 48: 3665-8. PMID 19353614 DOI: 10.1002/anie.200806103  1
2009 Benesch JL, Ruotolo BT, Sobott F, Wildgoose J, Gilbert A, Bateman R, Robinson CV. Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments. Analytical Chemistry. 81: 1270-4. PMID 19105602 DOI: 10.1021/ac801950u  1
2009 Lane LA, Ruotolo BT, Robinson CV, Favrin G, Benesch JLP. A Monte Carlo approach for assessing the specificity of protein oligomers observed in nano-electrospray mass spectra International Journal of Mass Spectrometry. 283: 169-177. DOI: 10.1016/j.ijms.2009.03.006  1
2008 Ruotolo BT, Benesch JL, Sandercock AM, Hyung SJ, Robinson CV. Ion mobility-mass spectrometry analysis of large protein complexes. Nature Protocols. 3: 1139-52. PMID 18600219 DOI: 10.1038/nprot.2008.78  1
2008 Taverner T, Hernández H, Sharon M, Ruotolo BT, Matak-Vinkovi? D, Devos D, Russell RB, Robinson CV. Subunit architecture of intact protein complexes from mass spectrometry and homology modeling. Accounts of Chemical Research. 41: 617-27. PMID 18314965 DOI: 10.1021/ar700218q  1
2007 Ruotolo BT, Hyung SJ, Robinson PM, Giles K, Bateman RH, Robinson CV. Ion mobility-mass spectrometry reveals long-lived, unfolded intermediates in the dissociation of protein complexes. Angewandte Chemie (International Ed. in English). 46: 8001-4. PMID 17854106 DOI: 10.1002/anie.200702161  1
2007 Benesch JL, Ruotolo BT, Simmons DA, Robinson CV. Protein complexes in the gas phase: technology for structural genomics and proteomics. Chemical Reviews. 107: 3544-67. PMID 17649985 DOI: 10.1021/cr068289b  1
2006 McKay AR, Ruotolo BT, Ilag LL, Robinson CV. Mass measurements of increased accuracy resolve heterogeneous populations of intact ribosomes. Journal of the American Chemical Society. 128: 11433-42. PMID 16939266 DOI: 10.1021/ja061468q  1
2006 Ruotolo BT, Robinson CV. Aspects of native proteins are retained in vacuum. Current Opinion in Chemical Biology. 10: 402-8. PMID 16935553 DOI: 10.1016/j.cbpa.2006.08.020  1
2006 Benesch JL, Aquilina JA, Ruotolo BT, Sobott F, Robinson CV. Tandem mass spectrometry reveals the quaternary organization of macromolecular assemblies. Chemistry & Biology. 13: 597-605. PMID 16793517 DOI: 10.1016/j.chembiol.2006.04.006  1
2006 Harrington AE, Morris-Triggs SA, Ruotolo BT, Robinson CV, Ohnuma S, Hyvönen M. Structural basis for the inhibition of activin signalling by follistatin. The Embo Journal. 25: 1035-45. PMID 16482217 DOI: 10.1038/sj.emboj.7601000  1
2005 Ruotolo BT, Giles K, Campuzano I, Sandercock AM, Bateman RH, Robinson CV. Evidence for macromolecular protein rings in the absence of bulk water. Science (New York, N.Y.). 310: 1658-61. PMID 16293722 DOI: 10.1126/science.1120177  1
2005 Aurikko JP, Ruotolo BT, Grossmann JG, Moncrieffe MC, Stephens E, Leppänen VM, Robinson CV, Saarma M, Bradshaw RA, Blundell TL. Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. The Journal of Biological Chemistry. 280: 33453-60. PMID 16009712 DOI: 10.1074/jbc.M503189200  1
2005 Sawyer HA, Marini JT, Stone EG, Ruotolo BT, Gillig KJ, Russell DH. The structure of gas-phase bradykinin fragment 1-5 (RPPGF) ions: an ion mobility spectrometry and H/D exchange ion-molecule reaction chemistry study. Journal of the American Society For Mass Spectrometry. 16: 893-905. PMID 15878286 DOI: 10.1016/j.jasms.2005.03.002  1
2005 Ruotolo BT, McLean JA, Gillig KJ, Russell DH. The influence and utility of varying field strength for the separation of tryptic peptides by ion mobility-mass spectrometry. Journal of the American Society For Mass Spectrometry. 16: 158-65. PMID 15694766 DOI: 10.1016/j.jasms.2004.10.006  1
2005 McLean JA, Ruotolo BT, Gillig KJ, Russell DH. Ion mobility-mass spectrometry: A new paradigm for proteomics International Journal of Mass Spectrometry. 240: 301-315. DOI: 10.1016/j.ijms.2004.10.003  1
2004 Ruotolo BT, Gillig KJ, Woods AS, Egan TF, Ugarov MV, Schultz JA, Russell DH. Analysis of phosphorylated peptides by ion mobility-mass spectrometry. Analytical Chemistry. 76: 6727-33. PMID 15538797 DOI: 10.1021/ac0498009  1
2004 Verbeck GF, Ruotolo BT, Gillig KJ, Russell DH. Resolution equations for high-field ion mobility. Journal of the American Society For Mass Spectrometry. 15: 1320-4. PMID 15337512 DOI: 10.1016/j.jasms.2004.06.005  1
2004 Ruotolo BT, Tate CC, Russell DH. Ion mobility-mass spectrometry applied to cyclic peptide analysis: conformational preferences of gramicidin S and linear analogs in the gas phase. Journal of the American Society For Mass Spectrometry. 15: 870-8. PMID 15144976 DOI: 10.1016/j.jasms.2004.02.006  1
2004 Ruotolo BT, McLean JA, Gillig KJ, Russell DH. Peak capacity of ion mobility mass spectrometry: the utility of varying drift gas polarizability for the separation of tryptic peptides. Journal of Mass Spectrometry : Jms. 39: 361-7. PMID 15103649 DOI: 10.1002/jms.592  1
2004 Ruotolo BT, Russell DH. Gas-phase conformations of proteolytically derived protein fragments: Influence of solvent on peptide conformation Journal of Physical Chemistry B. 108: 15321-15331. DOI: 10.1021/jp0490296  1
2004 Gillig KJ, Ruotolo BT, Stone EG, Russell DH. An electrostatic focusing ion guide for ion mobility-mass spectrometry International Journal of Mass Spectrometry. 239: 43-49. DOI: 10.1016/j.ijms.2004.09.005  1
2002 Verbeck GF, Ruotolo BT, Sawyer HA, Gillig KJ, Russell DH. A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules. Journal of Biomolecular Techniques : Jbt. 13: 56-61. PMID 19498967  1
2002 Ruotolo BT, Verbeck GF, Thomson LM, Woods AS, Gillig KJ, Russell DH. Distinguishing between phosphorylated and nonphosphorylated peptides with ion mobility-mass spectrometry. Journal of Proteome Research. 1: 303-6. PMID 12645885 DOI: 10.1021/pr025516r  1
2002 Ruotolo BT, Gillig KJ, Stone EG, Russell DH. Peak capacity of ion mobility mass spectrometry: separation of peptides in helium buffer gas. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 782: 385-92. PMID 12458020 DOI: 10.1016/S1570-0232(02)00566-4  1
2002 Koomen JM, Ruotolo BT, Gillig KJ, McLean JA, Russell DH, Kang M, Dunbar KR, Fuhrer K, Gonin M, Schultz JA. Oligonucleotide analysis with MALDI-ion-mobility-TOFMS. Analytical and Bioanalytical Chemistry. 373: 612-7. PMID 12185573 DOI: 10.1007/s00216-002-1363-2  1
2002 Ruotolo BT, Verbeck GF, Thomson LM, Gillig KJ, Russell DH. Observation of conserved solution-phase secondary structure in gas-phase tryptic peptides. Journal of the American Chemical Society. 124: 4214-5. PMID 11960442 DOI: 10.1021/ja0178113  1
2002 Woods AS, Koomen JM, Ruotolo BT, Gillig KJ, Russel DH, Fuhrer K, Gonin M, Egan TF, Schultz JA. A study of peptide-peptide interactions using MALDI ion mobility o-TOF and ESI mass spectrometry. Journal of the American Society For Mass Spectrometry. 13: 166-9. PMID 11838019 DOI: 10.1016/S1044-0305(01)00348-8  1
2002 Ruotolo BT, Gillig KJ, Stone EG, Russell DH, Fuhrer K, Gonin M, Schultz JA. Analysis of protein mixtures by matrix-assisted laser desorption ionization-ion mobility-orthogonal-time-of-flight mass spectrometry International Journal of Mass Spectrometry. 219: 253-267. DOI: 10.1016/S1387-3806(01)00583-8  1
2002 Ruotolo BT, Gillig KJ, McLean JA, Sawyer HA, Stone EG, Russell DH. Ion mobility/mass spectrometry: Advantages, challenges, and techniques on the horizon Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 119-120.  1
2002 Sawyer HA, Marini JT, Ruotolo BT, Russell DH. Effect of intra-molecular interactions on the gas-phase conformation of bradykinin as probed by ion-mobility mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 787-788.  1
2002 Ruotolo BT, McLean JA, Gillig KJ, Russell DH. Peak capacity of ion mobility-mass spectrometry: The utility of multiple bath gases for peptide separation Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 83-84.  1
2001 Stone E, Gillig KJ, Ruotolo B, Fuhrer K, Gonin M, Schultz A, Russell DH. Surface-induced dissociation on a MALDI-ion mobility-orthogonal time-of-flight mass spectrometer: sequencing peptides from an "in-solution" protein digest. Analytical Chemistry. 73: 2233-8. PMID 11393846 DOI: 10.1021/ac001430a  1
2001 Stone EG, Gillig KJ, Ruotolo BT, Russell DH. Optimization of a matrix-assisted laser desorption ionization-ion mobility-surface-induced dissociation-orthogonal-time-of-flight mass spectrometer: Simultaneous acquisition of multiple correlated MS1 and MS2 spectra International Journal of Mass Spectrometry. 212: 519-533. DOI: 10.1016/S1387-3806(01)00513-9  1
2000 Gillig KJ, Ruotolo B, Stone EG, Russell DH, Fuhrer K, Gonin M, Schultz AJ. Coupling high-pressure MALDI with ion mobility/orthogonal time-of-flight mass spectrometry. Analytical Chemistry. 72: 3965-71. PMID 10994952 DOI: 10.1021/ac0005619  1
2000 Spence DM, Knoll ED, Ruotolo BT, Bjerregaard J. Development of a sequential injection system in the capillary format for determinations of the IpaC protein Analytica Chimica Acta. 409: 3-8. DOI: 10.1016/S0003-2670(99)00760-6  1
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