James K. Coward - Publications

Affiliations: 
1987-2007 Medicinal Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases
Website:
https://www.lib.umich.edu/faculty-memoir/node/392

156 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Frantom PA, Coward JK, Blanchard JS. UDP-(5F)-GlcNAc acts as a slow-binding inhibitor of MshA, a retaining glycosyltransferase. Journal of the American Chemical Society. 132: 6626-7. PMID 20411981 DOI: 10.1021/Ja101231A  1
2010 Wang P, Wang Q, Yang Y, Coward JK, Nzila A, Sims PF, Hyde JE. Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. Molecular and Biochemical Parasitology. 172: 41-51. PMID 20350571 DOI: 10.1016/J.Molbiopara.2010.03.012  1
2010 McGuire JJ, Bartley DM, Tomsho JW, Haile WH, Coward JK. Corrigendum to "Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate" [Archives of Biochemistry and Biophysics 488 (2009) 140-145] (DOI:10.1016/j.abb.2009.06.017) Archives of Biochemistry and Biophysics. 493: 250. DOI: 10.1016/J.Abb.2009.11.011  1
2009 McGuire JJ, Bartley DM, Tomsho JW, Haile WH, Coward JK. Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 488: 140-5. PMID 19563773 DOI: 10.1016/J.Abb.2009.06.017  1
2009 Majumdar D, Alexander MD, Coward JK. Synthesis of isopeptide epoxide peptidomimetics. The Journal of Organic Chemistry. 74: 617-27. PMID 19086784 DOI: 10.1021/Jo801907P  1
2009 Hagena TL, Coward JK. Fluoridolysis of 5,6-epoxy carbohydrates: application to the synthesis of 5-fluoro lactosamine and isolactosamine glycosides Tetrahedron Asymmetry. 20: 781-794. DOI: 10.1016/J.Tetasy.2009.03.025  1
2008 Oza SL, Chen S, Wyllie S, Coward JK, Fairlamb AH. ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides. The Febs Journal. 275: 5408-21. PMID 18959765 DOI: 10.1111/J.1742-4658.2008.06670.X  1
2008 Coward JK, McGuire JJ. Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target. Vitamins and Hormones. 79: 347-73. PMID 18804701 DOI: 10.1016/S0083-6729(08)00412-3  1
2008 Tomsho JW, Moran RG, Coward JK. Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Biochemistry. 47: 9040-50. PMID 18672898 DOI: 10.1021/Bi800406W  1
2008 Alexander JP, Ryan TJ, Ballou DP, Coward JK. Gamma-glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates. Biochemistry. 47: 1228-39. PMID 18171026 DOI: 10.1021/Bi701607V  1
2007 Hartman MC, Jiang S, Rush JS, Waechter CJ, Coward JK. Glycosyltransferase mechanisms: impact of a 5-fluoro substituent in acceptor and donor substrates on catalysis. Biochemistry. 46: 11630-8. PMID 17883281 DOI: 10.1021/Bi700863S  1
2007 Yang Y, Coward JK. Synthesis of p-aminophenyl aryl H-phosphinic acids and esters via cross-coupling reactions: elaboration to phosphinic acid pseudopeptide analogues of pteroyl glutamic acid and related antifolates. The Journal of Organic Chemistry. 72: 5748-58. PMID 17602593 DOI: 10.1021/jo0707840  1
2006 Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH. Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. The Embo Journal. 25: 5970-82. PMID 17124497 DOI: 10.1038/sj.emboj.7601440  1
2006 Feng Y, Coward JK. Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability. Journal of Medicinal Chemistry. 49: 770-88. PMID 16420062 DOI: 10.1021/jm050871p  1
2006 Bartley DM, Coward JK. Regioselective synthesis of alpha-methyl 2-methyleneglutarate via a novel lactonization-elimination rearrangement. The Journal of Organic Chemistry. 71: 372-4. PMID 16388662 DOI: 10.1021/Jo051854A  1
2005 Tomsho JW, McGuire JJ, Coward JK. Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Organic & Biomolecular Chemistry. 3: 3388-98. PMID 16132101 DOI: 10.1039/B505907K  1
2005 Bartley DM, Coward JK. A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-gamma-glutamate and incorporation into potent inhibitors of folylpoly-gamma-glutamyl synthetase. The Journal of Organic Chemistry. 70: 6757-74. PMID 16095295 DOI: 10.1021/Jo0507439  1
2005 Ganguli ARS, Coward JK. α:β Selectivity in the synthesis of 3-substituted, 4-methyl umbelliferone glycosides of N-acetyl glucosamine and chitobiose Tetrahedron Asymmetry. 16: 411-424. DOI: 10.1016/J.Tetasy.2004.11.053  1
2003 Volk EL, Pankuch JJ, Chave KJ, Coward JK, Schneider E. A rapid assay for the quantitation of gamma-glutamyl hydrolase using a fluorogenic peptide as substrate. Biotechniques. 35: 926-8, 930, 932. PMID 14628664 DOI: 10.2144/03355Bm04  1
2003 McGuire JJ, Haile WH, Valiaeva N, Bartley D, Guo J, Coward JK. Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate. Biochemical Pharmacology. 65: 315-8. PMID 12527324 DOI: 10.1016/S0006-2952(02)01602-7  1
2003 McGuire JJ, Coward JK. Folylpolyglutamate synthetase as a target for therapeutic intervention Drugs of the Future. 28: 967-974. DOI: 10.1358/dof.2003.028.10.766680  1
2002 Hartman MC, Coward JK. Synthesis of 5-fluoro N-acetylglucosamine glycosides and pyrophosphates via epoxide fluoridolysis: versatile reagents for the study of glycoconjugate biochemistry. Journal of the American Chemical Society. 124: 10036-53. PMID 12188668 DOI: 10.1021/ja0127234  1
2002 Tsukamoto T, Flanary JM, Rojas C, Slusher BS, Valiaeva N, Coward JK. Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II. Bioorganic & Medicinal Chemistry Letters. 12: 2189-92. PMID 12127534 DOI: 10.1016/S0960-894X(02)00360-8  1
2002 Srinivasan A, Coward JK. A biotin capture assay for oligosaccharyltransferase. Analytical Biochemistry. 306: 328-35. PMID 12123673 DOI: 10.1006/Abio.2002.5699  1
2002 Konas DW, Pankuch JJ, Coward JK. The synthesis of (2S)-4,4-difluoroglutamyl γ-peptides based on Garner's aldehyde and fluoro-reformatsky chemistry Synthesis. 2616-2626. DOI: 10.1055/S-2002-35616  1
2001 Konas DW, Coward JK. Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids. The Journal of Organic Chemistry. 66: 8831-42. PMID 11749613 DOI: 10.1021/Jo0106804  1
2001 Valiaeva N, Bartley D, Konno T, Coward JK. Phosphinic acid pseudopeptides analogous to glutamyl-gamma-glutamate: synthesis and coupling to pteroyl azides leads to potent inhibitors of folylpoly-gamma-glutamate synthetase. The Journal of Organic Chemistry. 66: 5146-54. PMID 11463268 DOI: 10.1021/Jo010283T  1
2001 Pankuch JJ, Coward JK. N-Me-pAB-Glu-gamma-Glu-gamma-Tyr(3-NO(2)): an internally quenched fluorogenic gamma-glutamyl hydrolase substrate. Bioorganic & Medicinal Chemistry Letters. 11: 1561-4. PMID 11412981 DOI: 10.1016/S0960-894X(01)00103-2  1
2000 Varnado BL, Voci CJ, Meyer LM, Coward JK. Circular dichroism and NMR studies of metabolically stablealpha-methylpolyamines: spectral comparison with naturally occurring polyamines. Bioorganic Chemistry. 28: 395-408. PMID 11352474 DOI: 10.1006/Bioo.2000.1195  1
1999 Konas DW, Coward JK. Synthesis of L-4,4-difluoroglutamic acid via electrophilic difluorination of a lactam. Organic Letters. 1: 2105-7. PMID 10836063 DOI: 10.1021/Ol991150L  1
1999 Reddy A, Gibbs BS, Liu YL, Coward JK, Changchien LM, Maley F. Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitro. Glycobiology. 9: 547-55. PMID 10336987 DOI: 10.1093/Glycob/9.6.547  1
1999 Gibbs BS, Coward JK. Dolichylpyrophosphate oligosaccharides: large-scale isolation and evaluation as oligosaccharyltransferase substrates. Bioorganic & Medicinal Chemistry. 7: 441-7. PMID 10220030 DOI: 10.1016/S0968-0896(98)00268-5  1
1999 Coward JK. Synthesis and biochemical studies of phosphorus-based "tetrahedral mimics" as inhibitors of ATP-dependent ligases Phosphorus, Sulfur and Silicon and Related Elements. 144: 113-116. DOI: 10.1080/10426509908546195  1
1998 Chen S, Coward JK. Investigations on New Strategies for the Facile Synthesis of Polyfunctionalized Phosphinates: Phosphinopeptide Analogues of Glutathionylspermidine. The Journal of Organic Chemistry. 63: 502-509. PMID 11672038  1
1998 Xu T, Khanna H, Coward JK. The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase. Bioorganic & Medicinal Chemistry. 6: 1821-34. PMID 9839012 DOI: 10.1016/S0968-0896(98)00135-7  1
1998 Tsukamoto T, Haile WH, McGuire JJ, Coward JK. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 355: 109-18. PMID 9647673 DOI: 10.1006/Abbi.1998.0703  1
1998 Berdis AJ, Lee I, Coward JK, Stephens C, Wright R, Shapiro L, Benkovic SJ. A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 2874-9. PMID 9501183 DOI: 10.1073/Pnas.95.6.2874  1
1998 Xu T, Werner RM, Lee KC, Fettinger JC, Davis JT, Coward JK. Synthesis and Evaluation of Tripeptides Containing Asparagine Analogues as Potential Substrates or Inhibitors of Oligosaccharyltransferase Journal of Organic Chemistry. 63: 4767-4778. DOI: 10.1021/Jo9802123  1
1997 Xu T, Coward JK. 13C- and 15N-labeled peptide substrates as mechanistic probes of oligosaccharyltransferase. Biochemistry. 36: 14683-9. PMID 9398187 DOI: 10.1021/bi9719511  1
1997 Lin CH, Chen S, Kwon DS, Coward JK, Walsh CT. Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase. Chemistry & Biology. 4: 859-66. PMID 9384533 DOI: 10.1016/S1074-5521(97)90118-6  1
1997 Chen S, Lin CH, Kwon DS, Walsh CT, Coward JK. Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli. Journal of Medicinal Chemistry. 40: 3842-50. PMID 9371250 DOI: 10.1021/Jm970414B  1
1997 Kwon DS, Lin CH, Chen S, Coward JK, Walsh CT, Bollinger JM. Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains. The Journal of Biological Chemistry. 272: 2429-36. PMID 8999955 DOI: 10.1074/jbc.272.4.2429  1
1997 Chen S, Lin CH, Walsh CT, Coward JK. Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase Bioorganic and Medicinal Chemistry Letters. 7: 505-510. DOI: 10.1016/S0960-894X(97)00061-9  1
1996 McGuire JJ, Tsukamoto T, Hart BP, Coward JK, Kalman TI, Galivan J. Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy. Investigational New Drugs. 14: 317-23. PMID 8958187 DOI: 10.1007/Bf00194535  1
1996 McGuire JJ, Hart BP, Haile WH, Magee KJ, Rhee M, Bolanowska WE, Russell C, Galivan J, Paul B, Coward JK. Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites. Biochemical Pharmacology. 52: 1295-303. PMID 8937438 DOI: 10.1016/0006-2952(96)00485-6  1
1996 Burns MR, Coward JK. Synthesis of complex delta-acetylenic amino acids as potential multisubstrate adduct inhibitors of methyltransferases. Bioorganic & Medicinal Chemistry. 4: 1455-70. PMID 8894103 DOI: 10.1016/0968-0896(96)00139-3  1
1996 Tsukamoto T, Haile WH, McGuire JJ, Coward JK. Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine. Journal of Medicinal Chemistry. 39: 2536-40. PMID 8691451 DOI: 10.1021/Jm960046W  1
1996 Tsukamoto T, Kitazume T, McGuire JJ, Coward JK. Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate. Journal of Medicinal Chemistry. 39: 66-72. PMID 8568828 DOI: 10.1021/Jm950514M  1
1996 Hart BP, Haile WH, Licato NJ, Bolanowska WE, McGuire JJ, Coward JK. Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid. Journal of Medicinal Chemistry. 39: 56-65. PMID 8568827 DOI: 10.1021/Jm950515E  1
1996 Tsukamoto T, Coward JK. Facile synthesis of DL-4,4-difluoroornithine, DL-4,4-difluoroglutamine, and γ-DL-4,4-difluoroglutamyl-containing peptides: Regiospecific addition of nucleophiles to N-Cbz-di-tert-butyl-DL-4,4-difluoroglutamate Journal of Organic Chemistry. 61: 2497-2500. DOI: 10.1021/Jo952044+  1
1996 Chen S, Coward JK. A general method for the synthesis of N-protected α-aminoalkylphosphinic acids Tetrahedron Letters. 37: 4335-4338. DOI: 10.1016/0040-4039(96)00839-8  1
1996 Tsukamoto T, Coward JK, McGuire JJ. Fluoroamino Acid Containing Analogues of Folic Acid and Methotrexate Acs Symposium Series. 639: 117-128.  1
1995 McGuire JJ, Hart BP, Haile WH, Rhee MS, Galivan J, Coward JK. DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase. Archives of Biochemistry and Biophysics. 321: 319-28. PMID 7646057 DOI: 10.1006/abbi.1995.1401  1
1995 Pegg AE, Poulin R, Coward JK. Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function. The International Journal of Biochemistry & Cell Biology. 27: 425-42. PMID 7641073 DOI: 10.1016/1357-2725(95)00007-C  1
1995 Lakanen JR, Pegg AE, Coward JK. Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. Journal of Medicinal Chemistry. 38: 2714-27. PMID 7629810 DOI: 10.1021/Jm00014A023  1
1995 Yang J, Xiao L, Berkey KA, Tamez PA, Coward JK, Casero RA. Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine. Journal of Cellular Physiology. 165: 71-6. PMID 7559809 DOI: 10.1002/Jcp.1041650109  1
1995 Fang X, Gibbs BS, Coward JK. Synthesis and evaluation of synthetic analogues of dolichyl-P-P-chitobiose as oligosaccharyltransferase substrates Bioorganic and Medicinal Chemistry Letters. 5: 2701-2706. DOI: 10.1016/0960-894X(95)00460-B  1
1994 Byers TL, Lakanen JR, Coward JK, Pegg AE. The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. The Biochemical Journal. 303: 363-8. PMID 7980394 DOI: 10.1042/Bj3030363  1
1994 Liu YL, Hoops GC, Coward JK. A comparison of proteins and peptides as substrates for microsomal and solubilized oligosaccharyltransferase. Bioorganic & Medicinal Chemistry. 2: 1133-41. PMID 7757412 DOI: 10.1016/S0968-0896(00)82065-9  1
1994 Malachowski WP, Coward JK. The chemistry of phosphapeptides: Formation of functionalized phosphonochloridates under mild conditions and their reaction with alcohols and amines Journal of Organic Chemistry. 59: 7616-7624. DOI: 10.1021/Jo00104A016  1
1994 Malachowski WP, Coward JK. The chemistry of phosphapeptides: Investigations on the synthesis of phosphonamidate, phosphonate, and phosphinate analogues of glutamyl-γ-glutamate Journal of Organic Chemistry. 59: 7625-7634.  1
1993 Poulin R, Coward JK, Lakanen JR, Pegg AE. Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. The Journal of Biological Chemistry. 268: 4690-8. PMID 8444843  1
1993 Pegg AE, Coward JK. Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. Biochemical Pharmacology. 46: 717-24. PMID 8395844 DOI: 10.1016/0006-2952(93)90559-F  1
1993 Lee J, Coward JK. Oligosaccharyltransferase: synthesis and use of deuterium-labeled peptide substrates as mechanistic probes. Biochemistry. 32: 6794-801. PMID 8329402  1
1993 Hart BP, Coward JK. The synthesis of DL-3,3-Difluoroglutamic acid from a 3-oxoprolinol derivative Tetrahedron Letters. 34: 4917-4920. DOI: 10.1016/S0040-4039(00)74045-7  1
1993 Burns MR, Coward JK. A facile one-pot synthesis of homopropargylic alcohols from terminal acetylenes Journal of Organic Chemistry. 58: 528-532.  1
1992 Lakanen JR, Coward JK, Pegg AE. alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. Journal of Medicinal Chemistry. 35: 724-34. PMID 1542099 DOI: 10.1021/Jm00082A013  1
1992 Rhee MS, Coward JK, Galivan J. Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells. Molecular Pharmacology. 42: 909-16. PMID 1435754  1
1992 Lee J, Coward JK. Enzyme-catalyzed glycosylation of peptides using a synthetic lipid disaccharide substrate Journal of Organic Chemistry. 57: 4126-4135.  1
1991 Liu C, Coward JK. Stereospecific synthesis of (R)- and (S)-S-adenosyl-1,8-diamino-3-thiooctane, a potent inhibitor of polyamine biosynthesis. Comparison of asymmetric induction vs enantiomeric synthesis. Journal of Medicinal Chemistry. 34: 2094-101. PMID 2066981  1
1991 McGuire JJ, Bolanowska WE, Coward JK, Sherwood RF, Russell CA, Felschow DM. Biochemical and biological properties of methotrexate analogs containing D-glutamic acid or D-erythro, threo-4-fluoroglutamic acid. Biochemical Pharmacology. 42: 2400-3. PMID 1684899 DOI: 10.1016/0006-2952(91)90247-3  1
1991 Liu C, Coward JK. A facile and highly stereoselective synthesis of (R)- and (S)-[2-(phenylmethoxy)ethyl]oxirane Journal of Organic Chemistry. 56: 2262-2264.  1
1991 Clark RS, Banerjee S, Coward JK. Yeast oligosaccharyltransferase: Glycosylation of peptide substrates and chemical characterization of the glycopeptide product Journal of Organic Chemistry. 56: 6275-6285.  1
1990 Licato NJ, Coward JK, Nimec Z, Galivan J, Bolanowska WE, McGuire JJ. Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]- gamma-glutamate, an unusual substrate for folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase. Journal of Medicinal Chemistry. 33: 1022-7. PMID 2308134  1
1990 McGuire JJ, Haile WH, Bey P, Coward JK. DL-3,3-difluoroglutamate: an enhancer of folylpolyglutamate elongation. The Journal of Biological Chemistry. 265: 14073-9. PMID 1974895  1
1990 Yau EK, Coward JK. Synthesis of complex 6′-alkynyl-6′-dethia nucleoside analogues of S-adenosylhomocysteine as potential inhibitors of methyltransferases Journal of Organic Chemistry. 55: 3147-3158.  1
1989 Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026  1
1989 Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026  1
1989 McGuire JJ, Haile WH, Coward JK. Interaction of D, L-erythro- and D,L-threo-gamma-fluoromethotrexate with human leukemia cell dihydrofolate reductase. Biochemical Pharmacology. 38: 4321-5. PMID 2597202 DOI: 10.1016/0006-2952(89)90532-7  1
1989 McGuire JJ, Graber M, Licato N, Vincenz C, Coward JK, Nimec Z, Galivan J. Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation. Cancer Research. 49: 4517-25. PMID 2472880  1
1989 Miller RJ, Kuliopulos A, Coward JK. Alkyltransferase model reactions: Synthesis of sulfonium and ammonium compounds containing neighboring nucleophiles. Kinetic studies of the intramolecular reaction of amino, hydroxy, phenoxy, and mercapto onium salts Journal of Organic Chemistry. 54: 3436-3448.  1
1988 Lanzon-Miller S, Pounder RE, Ball SG, Dalgleish DJ, Coward J, Jackson AO. The effects of famotidine, 40 mg at night, on 24-hour intragastric acidity and plasma gastrin concentration in healthy subjects Scandinavian Journal of Gastroenterology. 23: 244-250. PMID 3283919 DOI: 10.3109/00365528809103975  1
1988 Coward JK. Aminopropyltransferases: mechanistic studies and the synthesis of specific inhibitors. Advances in Experimental Medicine and Biology. 250: 111-5. PMID 3076318 DOI: 10.1007/978-1-4684-5637-0_11  1
1988 Banerjee RV, Shane B, McGuire JJ, Coward JK. Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates. Biochemistry. 27: 9062-70. PMID 2906805 DOI: 10.1021/Bi00425A027  1
1988 Orr GR, Danz DW, Pontoni G, Prabhakaran PC, Gould SJ, Coward JK. Synthesis of chirally deuteriated (S-adenosyl-S-methylsulfonio)propylamines and spermidines. Elucidation of the stereochemical course of putrescine aminopropyltransferase (spermidine synthase) Journal of the American Chemical Society. 110: 5791-5799.  1
1988 Prabhakaran PC, Gould SJ, Orr GR, Coward JK. Synthesis of chirally deuteriated phthalimidopropanols and evaluation of their absolute stereochemistry Journal of the American Chemical Society. 110: 5779-5784.  1
1987 Coward JK, Pegg AE. Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells. Advances in Enzyme Regulation. 26: 107-13. PMID 3673702 DOI: 10.1016/0065-2571(87)90008-2  1
1987 McGuire JJ, Piper JR, Coward JK, Galivan J. Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs. Nci Monographs : a Publication of the National Cancer Institute. 139-44. PMID 2448652  1
1987 Johnson TB, Coward JK. Synthesis of oligophosphopeptides and related ATP γ-peptide esters as probes for cAMP-dependent protein kinase Journal of Organic Chemistry. 52: 1771-1779.  1
1986 Pegg AE, Coward JK, Talekar RR, Secrist JA. Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase. Biochemistry. 25: 4091-7. PMID 3091070 DOI: 10.1021/Bi00362A016  1
1986 Sherman ML, Shafman TD, Coward JK, Kufe DW. Selective inhibition of spermidine biosynthesis and differentiation by S-adenosyl-1,8-diamino-3-thiooctane in murine erythroleukemia cells. Biochemical Pharmacology. 35: 2633-6. PMID 2427085 DOI: 10.1016/0006-2952(86)90066-3  1
1985 Pegg AE, Coward JK. Growth of mammalian cells in the absence of the accumulation of spermine. Biochemical and Biophysical Research Communications. 133: 82-9. PMID 4074381 DOI: 10.1016/0006-291X(85)91844-3  1
1985 McGuire JJ, Coward JK. DL-threo-4-fluoroglutamic acid. A chain-terminating inhibitor of folylpolyglutamate synthesis. The Journal of Biological Chemistry. 260: 6747-54. PMID 2860109  1
1985 Galivan J, Inglese J, McGuire JJ, Nimec Z, Coward JK. gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates. Proceedings of the National Academy of Sciences of the United States of America. 82: 2598-602. PMID 2581252 DOI: 10.1073/pnas.82.9.2598  1
1985 Galivan J, Nimec Z, Coward JK, McGuire JJ. Glutamylation of methotrexate in hepatoma cells in vitro: regulation and the development of specific inhibitors. Advances in Enzyme Regulation. 23: 13-23. PMID 2416193 DOI: 10.1016/0065-2571(85)90038-X  1
1985 Galivan J, Coward JK, McGuire JJ. Effects of D,L-4-fluoroglutamic acid on glutamylation of methotrexate by hepatic cells in vitro. Biochemical Pharmacology. 34: 2995-7. PMID 2411272 DOI: 10.1016/0006-2952(85)90028-0  1
1984 Camper SA, Albers RJ, Coward JK, Rottman FM. Effect of undermethylation on mRNA cytoplasmic appearance and half-life. Molecular and Cellular Biology. 4: 538-43. PMID 6201720  1
1984 Orr GR, Gould SJ, Pegg AE, Seely JE, Coward JK. Stereochemistry of the decarboxylation of l-ornithine with ornithine decarboxylase from mouse kidney Bioorganic Chemistry. 12: 252-258. DOI: 10.1016/0045-2068(84)90009-9  1
1983 Pegg AE, Bitonti AJ, McCann PP, Coward JK. Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine. Febs Letters. 155: 192-6. PMID 6406265 DOI: 10.1016/0014-5793(82)80600-5  1
1983 McGuire JJ, Hsieh P, Coward JK, Bertino JR. In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein. Advances in Experimental Medicine and Biology. 163: 199-214. PMID 6193685  1
1983 Lashmet PR, Tang KC, Coward JK. The synthesis of an ATP-γ-Peptidyl ester as a potential probe of c-AMP-dependent protein kinases Tetrahedron Letters. 24: 1121-1124. DOI: 10.1016/S0040-4039(00)86381-9  1
1983 Pontoni G, Coward JK, Orr GR, Gould SJ. Stereochemical studies of enzyme-catalyzed alkyl-transfer reactions. An NMR method for distinguishing between the two prochiral hydrogens at C-1′ of spermidine Tetrahedron Letters. 24: 151-154. DOI: 10.1016/S0040-4039(00)81352-0  1
1983 Tang KC, Coward JK. Synthesis of acyl phosphonate analogues of biologically important acyl phosphates: N-(2-amino-10-methylpteroyl)-5-amino-2-oxopentanephosphonic acid Journal of Organic Chemistry. 48: 5001-5006.  1
1983 Coward JK, Anderson GL, Tang KC. Aminopropyltransferase substrates and inhibitors Methods in Enzymology. 286-294.  1
1982 Pegg AE, Tang KC, Coward JK. Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. Biochemistry. 21: 5082-9. PMID 6291600 DOI: 10.1021/Bi00263A036  1
1982 Vasquez PJ, Coward JK. Methylase models: Intramolecular alkylation of a phenol by an adenosyl sulphonium salt Journal of the Chemical Society, Chemical Communications. 698-699. DOI: 10.1039/C39820000698  1
1982 Knipe JO, Vasquez PJ, Coward JK. Methylase models: Studies on general-base vs. nucleophilic catalysis in the intramolecular alkylation of phenols Journal of the American Chemical Society. 104: 3202-3209.  1
1981 Tang KC, Mariuza R, Coward JK. Synthesis and evaluation of some stable multisubstrate adducts as specific inhibitors of spermidine synthase. Journal of Medicinal Chemistry. 24: 1277-84. PMID 7310803 DOI: 10.1021/jm00143a003  1
1981 Anderson GL, Bussolotti DL, Coward JK. Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase. Journal of Medicinal Chemistry. 24: 1271-7. PMID 7310802  1
1981 Pegg AE, Borchardt RT, Coward JK. Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts. The Biochemical Journal. 194: 79-89. PMID 7305994 DOI: 10.1042/Bj1940079  1
1981 Bali?ska M, Galivan J, Coward JK. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro. Cancer Research. 41: 2751-6. PMID 6166369  1
1980 Tang KC, Pegg AE, Coward JK. Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane. Biochemical and Biophysical Research Communications. 96: 1371-7. PMID 7437076 DOI: 10.1016/0006-291X(80)90102-3  1
1980 Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE. Studies of inhibition of rat spermidine synthase and spermine synthase. The Biochemical Journal. 187: 419-28. PMID 7396856 DOI: 10.1042/Bj1870419  1
1980 Cashmore AR, Dreyer RN, Horváth C, Knipe JO, Coward JK, Bertino JR. Separation of pteroyl-oligo-gamma-L-glutamates by high-performance liquid-chromatography. Methods in Enzymology. 66: 459-68. PMID 7374486 DOI: 10.1016/0076-6879(80)66489-1  1
1980 Woodard RW, Tsai MD, Floss HG, Crooks PA, Coward JK. Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase. The Journal of Biological Chemistry. 255: 9124-7. PMID 6997310  1
1980 McGuire JJ, Hsieh P, Coward JK, Bertino JR. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. The Journal of Biological Chemistry. 255: 5776-88. PMID 6892914  1
1979 Crooks PA, Dreyer RN, Coward JK. Metabolism of S-adenosylhomocysteine and S-tubercidinylhomocysteine in neuroblastoma cells. Biochemistry. 18: 2601-9. PMID 444479 DOI: 10.1021/Bi00579A026  1
1979 Crooks PA, Dreyer RN, Sulens CH, Gillis CN, Coward JK. Determination of 5-hydroxytryptamine metabolites in isolated perfused rabbit lung by high-performance liquid chromatography. Analytical Biochemistry. 93: 143-52. PMID 434457 DOI: 10.1016/S0003-2697(79)80128-1  1
1979 Coward JK. A mechanistic study of biological transmethylation. Psychopharmacology Bulletin. 15: 59-60. PMID 419260  1
1979 Gray CH, Coward JK, Barbara Schowen K, Schowen RL. α-Deuterium and carbon-13 isotope effects for a simple, intermolecular sulfur-to-oxygen methyl-transfer reaction. Transition-state structures and isotope effects in transmethylation and transalkylation Journal of the American Chemical Society. 101: 4351-4358. DOI: 10.1021/Ja00509A051  1
1979 Mihel I, Knipe JO, Coward JK, Schowen RL. α-Deuterium isotope effects and transition-state structure in an intramolecular model system for methyl-transfer enzymes Journal of the American Chemical Society. 101: 4349-4351. DOI: 10.1021/Ja00509A050  1
1979 Bush BT, Frenz JH, Melander WR, Horváth C, Cashmore AR, Dryer RN, Knipe JO, Coward JK, Bertino JR. Retention behavior of pteroyl-oligo-γ-l-glutamates in reversed-phase chromatography Journal of Chromatography A. 168: 343-353. DOI: 10.1016/0021-9673(79)80004-7  1
1979 Knipe JO, Coward JK. Role of buffers in a methylase model reaction. General base catalysis by oxyanions vs. nucleophilic dealkylation by amines Journal of the American Chemical Society. 101: 4339-4348.  1
1978 Crooks PA, Breakefield XO, Sulens CH, Castiglione CM, Coward JK. Extensive conjugation of dopamine (3,4-dihydroxyphenethylamine) metabolites in cultured human skin fibroblasts and rat hepatoma cells. The Biochemical Journal. 176: 187-96. PMID 569477 DOI: 10.1042/Bj1760187  1
1977 Coward JK, Motola NC, Moyer JD. Polyamine biosynthesis in rat prostate. Substrate and inhibitor properties of 7-deaza analogues of decarboxylated S-adenosylmethionine and 5'-methylthioadenosine. Journal of Medicinal Chemistry. 20: 500-5. PMID 850235  1
1977 Michelot RJ, Lesko N, Stout RW, Coward JK. Effect of S-adenosylhomocysteine and S-tubercidinylhomocysteine on catecholamine methylation in neuroblastoma cells. Molecular Pharmacology. 13: 368-73. PMID 558504  1
1976 Chang CD, Coward JK. Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage. Journal of Medicinal Chemistry. 19: 684-91. PMID 1271409  1
1976 Bertino JR, Coward JK, Cashmore A, Chello P, Panichajakul S, Horvath CG, Stout RW. Polyglutamate forms of folate: natural occurrence and role as substrates in mammalian cells. Biochemical Society Transactions. 4: 853-6. PMID 1069685  1
1976 Stout RW, Chang CD, Coward JK. Separation of methylated nucleosides by high-pressure liquid chromatography. The pattern of tRNA methylation in stimulated rat lymphocytes. Analytical Biochemistry. 76: 342-50. PMID 998971 DOI: 10.1016/0003-2697(76)90292-X  1
1976 Stout RW, Michelot RJ, Molnar I, Horvath C, Coward JK. An analytical method for the separation of dopamine metabolites in cellular extracts by high-pressure liquid chromatography. Analytical Biochemistry. 76: 330-41. PMID 998970 DOI: 10.1016/0003-2697(76)90291-8  1
1976 Stout RW, Cashmore AR, Coward JK, Horvath CG, Bertino JR. Separation of substituted pteroyl monoglutamates and pteroyl oligo-gamma-L-glutamates by high pressure liquid chromatography. Analytical Biochemistry. 71: 119-24. PMID 5905 DOI: 10.1016/0003-9861(76)90305-2  1
1976 Coward JK, Lok R, Takagi O. Letter: General base catalysis in nucleophilic attack at sp3 carbon of methylase model compounds. Journal of the American Chemical Society. 98: 1057-9. PMID 1441  1
1976 Lok R, Coward JK. Steric constraints in intramolecular reactions at sp3 carbon implications for methylase mechanisms Bioorganic Chemistry. 5: 169-175. DOI: 10.1016/0045-2068(76)90005-5  1
1976 Stout RW, Cashmore AR, Coward JK, Horvath CG, Bertino JR. Separation of substituted pteroyl monoglutamates and pteroyl oligo-γ-l-glutamates by high pressure liquid chromatography Analytical Biochemistry. 71: 119-124. DOI: 10.1016/0003-2697(76)90017-8  1
1975 Chang CD, Coward JK. Effect of S-adenosylhomocysteine and S-tubercidinylhomocysteine on transfer ribonucleic acid methylation in phytohemagglutinin-stimulated lymphocytes. Molecular Pharmacology. 11: 701-7. PMID 1207668  1
1975 Heller JS, Canellakis ES, Bussolotti DL, Coward JK. Stable multisubstrate adducts as enzyme inhibitors. Potent inhibition of ornithine decarboxylase by N-(5'-phosphopyridoxyl)-ornithine. Biochimica Et Biophysica Acta. 403: 197-207. PMID 1174545 DOI: 10.1016/0005-2744(75)90022-4  1
1975 Coward JK, Chello PL, Cashmore AR, Parameswaran KN, DeAngelis LM, Bertino JR. 5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain. Biochemistry. 14: 1548-52. PMID 1125187 DOI: 10.1021/Bi00678A032  1
1974 Coward JK, Parameswaran KN, Cashmore AR, Bertino JR. 7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources. Biochemistry. 13: 3899-903. PMID 4528865 DOI: 10.1021/Bi00716A013  1
1974 Coward JK, Bussolotti DL, Chang CD. Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S-tubercidinylhomocysteine. Journal of Medicinal Chemistry. 17: 1286-9. PMID 4473550  1
1974 Lok R, Coward JK. Stereospecific synthesis of 3,7-disubstituted bicyclo[3.3.0]octanes Journal of Organic Chemistry. 39: 2377-2382.  1
1973 Coward JK, Wu FY. A continuous spectrophotometric assay for catechol-O-methyltransferase. Analytical Biochemistry. 55: 406-10. PMID 4750682 DOI: 10.1016/0003-2697(73)90130-9  1
1973 Coward JK, Slixz EP, Wu FY. Kinetic studies on catechol O-methyltransferase. Product inhibition and the nature of the catechol binding site. Biochemistry. 12: 2291-7. PMID 4736330  1
1973 Coward JK, Slisz EP. Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Specificity of the S-adenosylhomocysteine binding site. Journal of Medicinal Chemistry. 16: 460-3. PMID 4718456  1
1973 Coward JK, Lok R. Cleavage of the N-carbobenzyloxy group in neutral and basic media. Neighboring-group participation of the carbamate moiety Journal of Organic Chemistry. 38: 2546-2548.  1
1973 Coward JK, Wu FYH. Kinetic studies on catechol O methyltransferase. Product inhibition and the nature of the catechol binding site Federation Proceedings. 32: 1870.  1
1972 Coward JK, D'Urso-Scott M, Sweet WD. Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog. Biochemical Pharmacology. 21: 1200-3. PMID 5064256 DOI: 10.1016/0006-2952(72)90114-1  1
1972 Coward JK, Sweet WD. Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis and biological activity of homocysteine derivatives bridged to adenine. Journal of Medicinal Chemistry. 15: 381-4. PMID 5019554  1
1971 Coward JK, Sweet WD. Kinetics and mechanism of methyl transfer from sulfonium compounds to various nucleophiles Journal of Organic Chemistry. 36: 2337-2346.  1
1969 Coward JK, Bruice TC. Mechanism of hydrolysis of primary and secondary enamines Journal of the American Chemical Society. 91: 5329-5339.  1
1969 Coward JK, Bruice TC. Intramolecular amine-catalyzed ketone enolization. A search for concerted intramolecular general-base, general-acid catalysis Journal of the American Chemical Society. 91: 5339-5345.  1
1967 Baker BR, Coward JK. Irreversible enzyme inhibitors. XCI. candidate active-site directed irreversible inhibitors of thymidylate synthetase. II. 2-amino-6-methyl-5-(p-tolylsulfonamidopropyl)-4-pyrimidinols with N-substituents on the sulfonamide moiety Journal of Heterocyclic Chemistry. 4: 202-208. DOI: 10.1002/jhet.5570040207  0.4
1967 Baker BR, Coward JK. Irreversible enzyme inhibitors. XC. candidate active-site-directed irreversible inhibitors of thymidylate synthetase. I. 2-amino-5-(benzenesulfonamidopropyl)-6-methyl-4-pyrimidinol with substituents on the benzene ring Journal of Heterocyclic Chemistry. 4: 195-201. DOI: 10.1002/jhet.5570040206  0.36
1967 Baker BR, Coward JK. Irreversible enzyme inhibitors. LXXXIX. candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. X. derivatives of 2-amino-5-benzamidopropyl-4-pyrimidinol Journal of Heterocyclic Chemistry. 4: 188-194. DOI: 10.1002/Jhet.5570040205  0.36
1966 Baker BR, Ho BT, Coward JK, Santi DV. Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid. Journal of Pharmaceutical Sciences. 55: 302-8. PMID 5960176 DOI: 10.1002/Jps.2600550308  1
1966 Baker BR, Santi DV, Coward JK, Shapiro HS, Jordaan JH. Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitors Journal of Heterocyclic Chemistry. 3: 425-434. DOI: 10.1002/Jhet.5570030407  0.76
1965 Baker BR, Coward JK. Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol thymidylate synthetase. 3. Journal of Pharmaceutical Sciences. 54: 714-9. PMID 5847011 DOI: 10.1002/Jps.2600540511  1
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