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Bernard Randall Baker, Ph.D. - Publications

Affiliations: 
1946-1950 Chemistry Teaneck College 
 1961-1966 Medicinal Chemistry State University of New York, Buffalo, Buffalo, NY, United States 
 1966-1971 Chemistry University of California, Santa Barbara, Santa Barbara, CA, United States 
Area:
Cannabis alkaloids, Antimalarials, nucleosides, carbohydrates
Website:
https://www.acsmedchem.org/medi-hall-of-fame-inductees-acs
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Year Citation  Score
2012 Baker BR, Kawazu M. Irreversible Enzyme Inhibitors. LXXX.(1,2) Inhibitors of Thymidine Phosphorylase. VI.(2) Hydrophobic Bonding with 6 Substituents on the Acidic 5-Nitro- and 5-Bromouracils. Journal of Medicinal Chemistry. 10: 316-20. PMID 22185122 DOI: 10.1021/Jm00315A006  0.642
2012 Baker BR, Kawazu M. Irreversible Enzyme Inhibitors. LXXVI.(1,2) Inhibitors of Thymidine Phosphorylase. II.(2) Hydrophobic Bonding by 1-Substituted Uracils. Journal of Medicinal Chemistry. 10: 302-4. PMID 22185118 DOI: 10.1021/Jm00315A002  0.604
1996 BAKER BR, SHAPIRO HS, WERKHEISER WC. ANALOGS OF TETRAHYDROFOLIC ACID. 18. ON THE MODE OF BINDING OF SOME 6-ARYL- AND 6-ARALKYLPYRIMIDINES TO FOLIC REDUCTASE. Journal of Medicinal Chemistry. 8: 283-7. PMID 14323133 DOI: 10.1021/Jm00327A002  0.325
1996 BAKER BR, JORDAAN JH. ANALOGS OF TETRAHYDROFOLIC ACID. XVII. ON THE MODE OF BINDING OF THE P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE. Journal of Medicinal Chemistry. 8: 35-41. PMID 14287264 DOI: 10.1021/Jm00325A009  0.37
1996 BAKER BR, SACHDEV K. ANALOGS OF TETRAHYDROFOLIC ACID. XI. SYNTHESIS AND ENZYMIC EVALUATION OF P-((N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL)CARBAMOYLMETHYL)AMINO)BENZOYL-L-GLUTAMIC ACID. Journal of Pharmaceutical Sciences. 53: 1020-3. PMID 14234885 DOI: 10.1002/jps.2600530906  0.333
1996 BAKER BR, PATEL RP. NONCLASSICAL ANTIMETABOLITES. XV. BRIDGE PRINCIPLE OF SPECIFICITY WITH ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS. VI. HIGHLY SELECTIVE IRREVERSIBLE INHIBITION OF LACTIC DEHYDROGENASE. Journal of Pharmaceutical Sciences. 53: 714-20. PMID 14209464 DOI: 10.1002/jps.2600530703  0.432
1996 BAKER BR, SHAPIRO HS. ANALOGS OF TETRAHYDROFOLIC ACID. IX. SYNTHESIS OF N-(1-(2-AMINO-4-HYDROXY-6-PHENYL-5-PYRIMIDYL)-3-PROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID, A "NONCLASSICAL" INHIBITOR OF SOME FOLIC COFACTOR AREA ENZYMES. Journal of Medicinal Chemistry. 6: 664-9. PMID 14184922 DOI: 10.1021/Jm00342A009  0.512
1996 BAKER BR, SACHDEV HS. NONCLASSICAL ANTIMETABOLITES. XIII. SIMULATION OF THE 5'PHOSPHORIBOSYL MOIETY OF 5'-ADENYLIC ACID AT THE ENZYME LEVEL BY OMEGA-CARBOXYALKYL AND ARALKYL GROUPS ATTACHED TO ADENINE. Journal of Pharmaceutical Sciences. 52: 933-40. PMID 14076499 DOI: 10.1002/jps.2600521005  0.347
1996 BAKER BR, PATEL RP. NONCLASSICAL ANTIMETABOLITES. XII. BRIDGE PRINCIPLE OF SPECIFICITY WITH EXO-ALKYLATING IRREVERSIBLE INHIBITORS. V. DIFFERENCES IN SPECIFICITY OF ENZYMIC NUCLEOPHILIC SITES AS DETECTED BY THE CARBOPHENOXY GROUP. Journal of Pharmaceutical Sciences. 52: 927-33. PMID 14076498 DOI: 10.1002/jps.2600521004  0.43
1996 BAKER BR, ALUMAULA PI. NONCLASSICAL ANTIMETABOLITES. XVI. THE BRIDGE PRINCIPLE OF SPECIFICITY WITH ACTIVE SITE-DIRECTED IRREVERSIBLE INHIBITORS. VII. DETECTION OF DIFFERENCES IN SPECIFICITY OF ENZYMIC NUCLEOPHILIC SITES BY THE MALEAMYL GROUP. Journal of Pharmaceutical Sciences. 52: 914-5. PMID 14061061 DOI: 10.1002/jps.2600520926  0.401
1996 BAKER BR, MORREAL CE. ANALOGS OF TETRAHYDROFOLIC ACID. VII. SYNTHESIS OF N-(1-(2-AMINO- 4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE. Journal of Pharmaceutical Sciences. 52: 840-3. PMID 14061041 DOI: 10.1002/jps.2600520905  0.329
1982 Kelley JL, Baker BR. Irreversible enzyme inhibitors. 202. Candidate active-site-directed irreversible inhibitors of 5-fluoro-2'-deoxyuridine phosphorylase from Walker 256 rat tumor derived from 1-benzyl-5-(3-ethoxybenzyl)uracil. Journal of Medicinal Chemistry. 25: 600-3. PMID 6211547 DOI: 10.1002/Chin.198241232  0.577
1977 Ward AD, Baker BR. Irreversible enzyme inhibitors. 200. Active-site-directed inhibitors of deoxycytidine kinase. Journal of Medicinal Chemistry. 20: 88-92. PMID 189030  0.505
1976 Doll MH, Baker BR. Irreversible enzyme inhibitors. Inhibitors of guinea pig complement derived by quaternization of substituted pyridines with benzyl halides. Journal of Medicinal Chemistry. 19: 1079-88. PMID 978671  0.403
1974 Gibson RE, Baker BR. Enzyme inhibitors. Inhibition of brain choline acetyltransferase by derivatives of 4-styrylpyrimidine. Journal of Medicinal Chemistry. 17: 1290-3. PMID 4473551 DOI: 10.1002/Chin.197515274  0.549
1973 Ashton WT, Kirk LL, Baker BR. Irreversible enzyme inhibitors. 198. Diaminodihydro-S-triazines and diaminopyrimidines bearing substituted (ureidomethyl)phenyl substituents as reversible inhibitors of dihydrofolate reductase. Journal of Medicinal Chemistry. 16: 453-6. PMID 4736964 DOI: 10.1021/Jm00263A006  0.637
1973 Baker BR, Ashton WT. Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine. Journal of Medicinal Chemistry. 16: 209-14. PMID 4733101 DOI: 10.1021/Jm00261A009  0.593
1972 Baker BR, Neenan JP. Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derived from thymidine 5'-acetate. Journal of Medicinal Chemistry. 15: 940-4. PMID 5065786  0.474
1972 Baker BR, Bramhall RR. Irreversible enzyme inhibitors. 192. Hydrophobic bonding to some dehydrogenases with 5-substituted-4-hydroxyquinoline-3-carboxylic acids. Journal of Medicinal Chemistry. 15: 237-41. PMID 5062068  0.542
1972 Baker BR, Bramhall RR. Irreversible enzyme inhibitors. 191. Hydrophobic bonding to some dehydrogenases by 6-, 7-, or 8-substituted-4-hydroxyquinoline-3-carboxylic acids. Journal of Medicinal Chemistry. 15: 235-7. PMID 5059208  0.542
1972 Baker BR, Bramhall RR. Irreversible enzyme inhibitors. 190. Inhibition of some dehydrogenases by l-substituted-1,4-dihydro-4-quinoline-3-carboxylic acids. Journal of Medicinal Chemistry. 15: 233-5. PMID 5059207  0.534
1972 Baker BR, Bramhall RR. Irreversible enzyme inhibitors. 189. Inhibition of some dehydrogenases by derivatives of 4-hydroxyquinoline-2 and -3-carboxylic acids. Journal of Medicinal Chemistry. 15: 230-3. PMID 5059206  0.584
1972 Baker BR, Ashton WT. Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group. Journal of Medicinal Chemistry. 15: 945-7. PMID 5051014 DOI: 10.1021/Jm00279A017  0.627
1972 Baker BR, Bramhall RR. Irreversible enzyme inhibitors. 194. Hydrophobic bonding to some dehydrogenases by substituted 5-phenylethyl-4-hydroxyquinoline-3-carboxylic acids. Journal of Medicinal Chemistry. 15: 937-40. PMID 5051013  0.542
1972 Baker BR, Gibson RE. Irreversible enzyme inhibitors. 193. Inhibition of choline acetyltransferase. Mode of binding by 4-stilbazoles. Journal of Medicinal Chemistry. 15: 639-42. PMID 5030932 DOI: 10.1021/Jm00276A019  0.534
1971 Baker BR, Cory M. Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide. Journal of Medicinal Chemistry. 14: 119-25. PMID 5544395 DOI: 10.1021/Jm00284A009  0.54
1971 Baker BR, Schaefer JC. Irreversible enzyme inhibitors. 187. Studies on bulk tolerance with inhibitors of guanosine phosphorylase. Journal of Medicinal Chemistry. 14: 809-12. PMID 5168673  0.552
1971 Baker BR, Siebenneick HU. Irreversible enzyme inhibitors. 185. Active-site-directed irreversible inhibitors of guanine deaminase derived from 9-phenylguanine bearing a terminal sulfonyl fluoride. 2. Journal of Medicinal Chemistry. 14: 802-5. PMID 5168672  0.571
1971 Baker BR, Doll MH. Irreversible enzyme inhibitors. 183. Proteolytic enzymes. 18. Inhibitors of guinea pig complement derived by quaternization of phenylalkylpyridines with -bromomethylbenzenesulfonyl fluorides. Journal of Medicinal Chemistry. 14: 793-9. PMID 5168671 DOI: 10.1021/Jm00291A004  0.631
1971 Baker BR, Cory M. Irreversible enzyme inhibitors. 186. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine by bridging to a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 14: 805-8. PMID 5140007 DOI: 10.1021/Jm00291A007  0.544
1971 Baker BR, Siebeneick HU. Irreversible enzyme inhibitors. 184. An affinity column for purification of rat liver guanine deaminase and xanthine oxidase. Journal of Medicinal Chemistry. 14: 799-801. PMID 5140006  0.387
1971 Baker BR, Gibson RE. Irreversible enzyme inhibitors. 181. Inhibition of brain choline acetyltransferase by derivatives of 4-stilbazole. Journal of Medicinal Chemistry. 14: 315-22. PMID 5102840 DOI: 10.1021/Jm00286A011  0.552
1971 Baker BR. Active-site directed irreversible inhibitors of dihydrofolate reductase. Annals of the New York Academy of Sciences. 186: 214-26. PMID 4943574  0.415
1971 Baker BR, Kelley JL. Irreversible enzyme inhibitors. 188. Inhibition of mammalian thymidine phosphorylase. Journal of Medicinal Chemistry. 14: 812-6. PMID 4258703 DOI: 10.1021/Jm00291A009  0.62
1970 Baker BR, Ashton WT. Irreversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 13: 1165-70. PMID 5479858 DOI: 10.1021/Jm00300A032  0.639
1970 Baker BR, Ashton WT. Irreversible enzyme inhibitors. 178. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 13: 1161-5. PMID 5479857 DOI: 10.1021/Jm00300A031  0.636
1970 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II. Journal of Medicinal Chemistry. 13: 1154-60. PMID 5479856 DOI: 10.1021/Jm00300A030  0.616
1970 Baker BR, Ashton WT. Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 13: 1149-54. PMID 5479855 DOI: 10.1021/Jm00300A029  0.639
1970 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CLXXV. Irreversible inhibition of purified dihydrofolic reductase. Journal of Medicinal Chemistry. 13: 1143-8. PMID 5479854 DOI: 10.1021/Jm00300A028  0.621
1970 Ryan AJ, Vermeulen NM, Baker BR. Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-(p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido)-o-toluenesulfonyl fluoride (NSC-113423), an active-site-directed irreversible inhibitor of dihydrofolic reductase. Journal of Medicinal Chemistry. 13: 1140-2. PMID 5479853 DOI: 10.1021/Jm00300A027  0.559
1970 Baker BR, Vermeulen NM, Ashton WT, Ryan AJ. Irreversible enzyme inhibitors. 173. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihydrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine. Journal of Medicinal Chemistry. 13: 1130-40. PMID 5479852 DOI: 10.1021/Jm00300A026  0.64
1970 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CLXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 2,4-diamino-5(3,4-dichlorophenyl)pyrimidine with 6 substituents and some factors in their cell wall transport. Journal of Medicinal Chemistry. 13: 82-6. PMID 5460895 DOI: 10.1021/Jm00295A021  0.577
1970 Cardinaud R, Baker BR. Irreversible enzyme inibitiors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active site of alpha-chymotrypsin by exo-type active-site directed irreversible inhibitors. Journal of Medicinal Chemistry. 13: 467-70. PMID 5460302 DOI: 10.1021/Jm00297A030  0.542
1970 Baker BR, Vermeulen NM, Ryan AJ. Irreversible enzyme inhibitors. 168. Irreversible inhibition of dihydrofolate reductase and cell wall transport by pyrimidines and dihydro-s-triazines with pyridinium side chains. Journal of Medicinal Chemistry. 13: 280-4. PMID 5418502 DOI: 10.1021/Jm00296A027  0.533
1970 Baker BR. Specific irreversible enzyme inhibitors. Annual Review of Pharmacology. 10: 35-50. PMID 4986559 DOI: 10.1146/annurev.pa.10.040170.000343  0.55
1970 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CLXXI. Inhibition of FUDR phosphorylase from Walker 256 rat tumor by 5-substituted uracils. Journal of Medicinal Chemistry. 13: 461-7. PMID 4245517 DOI: 10.1021/Jm00297A029  0.513
1970 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CLXX. Inhibition of FUDR phosphorylase from Walker 256 rat tumor by 1-substituted uracils. Journal of Medicinal Chemistry. 13: 458-61. PMID 4245516  0.424
1970 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CLXIX. Inhibition of FUDR phosphorylase from Walker 256 rat tumor by 6-substituted uracils. Journal of Medicinal Chemistry. 13: 456-8. PMID 4245515  0.424
1970 Baker BR, Hopkins SE. Irreversible enzyme inhibitors. CLXVII. Thymidine phosphorylase. X. On the nature and dimensions of the hydrophobic bonding region. II. Journal of Medicinal Chemistry. 13: 87-9. PMID 4243954  0.41
1970 Baker B, Vermeulen N, Ryan A. Additions and Corrections - Irreversible Enzyme Inhibitors. CLXVIII. Journal of Medicinal Chemistry. 13: 1253-1253. DOI: 10.1021/Jm00300A603  0.612
1970 Ryan AJ, Vermeulen NMJ, Baker BR. Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-[p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido]-o- toluenesulfonyl fluoride (NSC-113423), an active-site-directed irreversible inhibitor of dihydrofolic reductase Journal of Medicinal Chemistry. 13: 1140-1142.  0.479
1970 Baker BR, Vermeulen NMJ, Ashton WT, Ryan AJ. Irreversible enzyme inhibitors. CLXXIII. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihyclrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine Journal of Medicinal Chemistry. 13: 1130-1140.  0.574
1970 Baker BR, Vermeulen NMJ, Ryan AJ. Irreversible enzyme inhibitors. CLXVIII. Irreversible inhibition of dihydrofolate reductase and cell wall transport by pyrimidines and dihydro-s-triazines with pyridinium side chains Journal of Medicinal Chemistry. 13: 280-284.  0.447
1970 Baker BR, Vermeulen NMJ. Irreversible enzyme inhibitors. CLXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with 6 substituents and some factors in their cell wall transport Journal of Medicinal Chemistry. 13: 82-86.  0.5
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CLVII. Effect of bridge modification on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosultonyl-benzamidomethyl) phenozymethyl]pyrimidine. I. Journal of Medicinal Chemistry. 12: 680-4. PMID 5822623  0.422
1969 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CLVI. Proteolytic enzymes. XII. Inhibitors of guinea pig complement derived by quaternization of 3-acylamidopyridines with alpha-bromomethylbenzenesulfonyl fluorides. Journal of Medicinal Chemistry. 12: 677-80. PMID 5815693  0.51
1969 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CLXI. Proteolytic enzymes. 13. Inhibitors of guinea pig complement derived by quaternization of 3-acylamidopyridines with alpha-bromomethylbenzenesulfonyl fluorides. II. Journal of Medicinal Chemistry. 12: 902-5. PMID 5812209  0.502
1969 Baker BR, Janson EE, Vermeulen NM. Irreversible enzyme inhibitors. CLX. Some factors in cell wall transport of active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. Journal of Medicinal Chemistry. 12: 898-902. PMID 5812208 DOI: 10.1021/Jm00305A043  0.57
1969 Baker BR, Ashton WT. Irreversible enzyme inhibitors. CLIX. Effect of substitution on transport and isozyme specificity of p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)-o-chlorophenoxyacetamido-benzenesulfonyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Journal of Medicinal Chemistry. 12: 894-7. PMID 5812207 DOI: 10.1021/Jm00305A042  0.572
1969 Baker BR, Vermuelen NM. Irreversible enzyme inhibitors. 158. Effect of bridge modification on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamidomethyl)phenoxymethyl]pyrimidine. II. Journal of Medicinal Chemistry. 12: 684-8. PMID 5793162 DOI: 10.1021/Jm00304A028  0.51
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CLVII. Effect of bridge modification on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamidomethyl)phenoxymethyl]pyrimidine. I. Journal of Medicinal Chemistry. 12: 680-4. PMID 5793161  0.422
1969 Baker BR, Janson EE. Irreversible enzyme inhibitors. CLV. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[4-(omega-aminoalkoxy)-3-chlorophenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 672-6. PMID 5793160  0.575
1969 Baker BR, Meyer RB. Irreversible enzyme inhibitors. CLIV. Some factors in cell wall transport of active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-substituted 2,4-diaminopyrimidines. Journal of Medicinal Chemistry. 12: 668-71. PMID 5793159 DOI: 10.1021/Jm00304A024  0.577
1969 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. 53. Proteolytic enzymes. XI. Inhibition of guinea pig complement by substituted phenoxyacetamides. Journal of Medicinal Chemistry. 12: 415-9. PMID 5788156 DOI: 10.1021/Jm00303A017  0.62
1969 Baker BR, Erickson EH. Irreversible enzyme inhibitors. CLII. Proteolytic enzymes. X. Inhibition of guinea pig complement by substituted benzamidines. Journal of Medicinal Chemistry. 12: 408-14. PMID 5788155 DOI: 10.1021/Jm00303A016  0.597
1969 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CL. Proteolytic enzymes. IX. (3,4-Dichlorophenoxyacetamido)pyridines bridged by a quaternary salt to a terminal sulfonyl fluoride. Potent irreversible inhibitors of alpha-chymotrypsin. Journal of Medicinal Chemistry. 12: 221-4. PMID 5783594 DOI: 10.1021/Jm00302A006  0.591
1969 Baker BR, Wood WF. Irreversible enzyme inhibitors. 148. Active-site-directed irreversible inhibitors of guanine deaminase derived from 9-phenylguanine bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 216-20. PMID 5783593 DOI: 10.1021/Jm00302A005  0.636
1969 Baker BR, Wood WF. Irreversible enzyme inhibitors. CXLVII. Candidate active-site-directed irreversible inhibitors of xanthine oxidase derived from 9-(p-acylamidoalkoxyphenyl)guanines bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 214-6. PMID 5783592 DOI: 10.1021/Jm00302A004  0.633
1969 Baker BR, Wood WF. Irreversible enzyme inhibitors. CXLVI. Active-site-directed irreversible inhibitors of xanthine oxidase derived from 9-(acylamidophenyl)guanines substituted with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 211-4. PMID 5783591 DOI: 10.1021/Jm00302A003  0.642
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenz amido) phenoxymethyl] pyrimidine, an active-site-directed irreverisible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity. Journal of Medicinal Chemistry. 12: 82-5. PMID 5777842 DOI: 10.1021/Jm00301A021  0.585
1969 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXL. Active-site-directed irreversible inhibitors derived from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine. Journal of Medicinal Chemistry. 12: 95-101. PMID 5763050 DOI: 10.1021/Jm00301A025  0.628
1969 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. VI. Further studies on effects of substitution on the propionamide bridge on isozyme specificity. Journal of Medicinal Chemistry. 12: 92-4. PMID 5763049  0.561
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. 138. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenethyl)-- 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 89-91. PMID 5763048  0.572
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 86-8. PMID 5763047 DOI: 10.1021/Jm00301A022  0.637
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity. Journal of Medicinal Chemistry. 12: 82-5. PMID 5763046  0.511
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CXXXV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(p-fluorosulfonyl-phenylureido)phenoxymethyl]pyrimidine. Journal of Medicinal Chemistry. 12: 79-81. PMID 5763045 DOI: 10.1021/Jm00301A020  0.514
1969 Baker BR, Vermeulen NM. Irreversible enzyme inhibitors. CXXXIV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonyl-phenylureido)phenoxymethyl]pyrimidine. Journal of Medicinal Chemistry. 12: 74-8. PMID 5763044  0.431
1969 Baker BR, Lourens GJ, Meyer RB, Vermeulen NM. Irreversible enzyme inhibitors. 133. Studies on differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse. Journal of Medicinal Chemistry. 12: 67-73. PMID 5763043 DOI: 10.1021/Jm00301A018  0.465
1969 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CXLV. Proteolytic enzymes. 8. Active-site-directed irreversible inhibitors of alpha-chymotrypsin derived from alpha-(2-carboxy-4-chlorophenoxy)acetamide bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 118-22. PMID 5763006 DOI: 10.1021/Jm00301A030  0.523
1969 Baker BR, Erickson EH. Irreversible enzyme inhibitors. CXLIV. Proteolytic enzymes. VII. Additonal active-site-directed irreversible inhibitors of trypsin derived from m- and p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 112-7. PMID 5763005 DOI: 10.1021/Jm00301A029  0.624
1969 Baker BR, Meyer RB. Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 108-11. PMID 5763004 DOI: 10.1021/Jm00301A028  0.634
1969 Baker BR, Meyer RB. Irreversible enzyme inhibitors. CXLII. Further studies on active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-Aminophenoxypropyl)-2,4,6-triaminopyrimidine bearing a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 104-7. PMID 5763003 DOI: 10.1021/Jm00301A027  0.633
1969 Baker BR, Cory M. Irreversible enzyme inhibitors. CLXV. Proteolytic enzymes. XV. Inhibition of guinea pig complement by derivatives of m-phenoxypropoxybenzamidine. Journal of Medicinal Chemistry. 12: 1053-6. PMID 5389147 DOI: 10.1021/Jm00306A020  0.585
1969 Baker BR, Cory M. Irreversible enzyme inhibitors. CLXIV. Proteolytic enzymes. XIV. Inhibition of guinea pig complement by meta-substituted benzamidines. Journal of Medicinal Chemistry. 12: 1049-52. PMID 5389146 DOI: 10.1021/Jm00306A019  0.616
1969 Baker BR, Kelley JL. Irreversible enzyme inhibitors. 73. Active-site-directed irreversible inhibitors of cytosine nucleoside deaminase derived from 1-phenoxypropyl-5-arylcytosines. Journal of Medicinal Chemistry. 12: 1046-9. PMID 5351446 DOI: 10.1021/Jm00306A018  0.636
1969 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CLXII. Hydrophobic bonding to cytosine nucleoside deaminase with 1-substituted 5-arylcytosines. Journal of Medicinal Chemistry. 12: 1039-45. PMID 5351445 DOI: 10.1021/Jm00306A017  0.599
1969 Baker BR, Meyer RB. Irrevesible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 12: 224-7. PMID 5254099 DOI: 10.1021/Jm00302A007  0.632
1969 Baker B, Hurlbut J. Additions and Corrections - Irreversible Enzyme Inhibitors. CXIII. Proteolytic Enzymes. III. Active-Site-Directed Irreversible Inhibitors of α-Chymotrypsin Derived from Phenoxyacetamides with an N-Fluorosulfonylphenyl Substituent. Journal of Medicinal Chemistry. 12: 1127-1127. DOI: 10.1021/Jm00306A603  0.606
1969 Baker BR. Tissue-specific irreversible inhibitors of dihydrofolic reductase Accounts of Chemical Research. 2: 129-136.  0.323
1968 Baker BR, Huang PC, Pogolotti AL. Irreversible enzyme inhibitors. 108. 6-(p-chloroacetylanilinomethyl)-5-(p-chlorophenyl)-2,4-diaminopyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Journal of Medicinal Chemistry. 10: 1134-8. PMID 6056043 DOI: 10.1021/jm00318a032  0.498
1968 Baker BR, Erickson EH. Irreversible enzyme inhibitors. CVI. Proteolytic enzymes. I. Bulk tolerances in trypsin-inhibitor complexes. Journal of Medicinal Chemistry. 10: 1123-8. PMID 6056041 DOI: 10.1021/Jm00318A030  0.606
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CV. Differential irreversible inhibition of vertebrate dihydrofolic reductases by derivatives of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazines substituted with a terminal sulfonyl fluoride. Journal of Medicinal Chemistry. 10: 1113-22. PMID 6056040 DOI: 10.1021/Jm00318A029  0.61
1968 Baker BR, Rzeszotarski W. Irreversible enzyme inhibitors. CIV. Inhibitors of thymidine phosphorylase. 8. Further studies on hydrophobic bonding with 6-substituted uracils. Journal of Medicinal Chemistry. 10: 1109-13. PMID 6056039 DOI: 10.1021/jm00318a028  0.558
1968 Baker BR, Wood WF. Irreversible enzyme inhibitors. 103. 9-(p-Bromoacetamidophenyl)guanine, an irreversible inhibitor of xanthine oxidase. Journal of Medicinal Chemistry. 10: 1106-9. PMID 6056038 DOI: 10.1021/Jm00318A027  0.617
1968 Baker BR, Wood WF. Irreversible enzyme inhibitors. CII. On the mode of phenyl binding of 9-phenylguanine to guanine deaminase and xanthine oxidase. Journal of Medicinal Chemistry. 10: 1101-5. PMID 6056037 DOI: 10.1021/Jm00318A026  0.526
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[p-(p-fluorosulfonylphenylureidomethyl)-phenyl]-4,6-diamino-1,2-dihydro-2,2- dimethyl-s-triazine Journal of Medicinal Chemistry. 12: 101-104. PMID 5763002 DOI: 10.1021/Jm00301A026  0.59
1968 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CXXXII. Proteolytic enzymes. VI. Tolerance for polar groups on the phenoxyacetanilide type of inhibitor of α-chymotrypsin Journal of Medicinal Chemistry. 11: 1054-1059. PMID 5697070 DOI: 10.1021/Jm00311A032  0.568
1968 Baker BR, Wood WF, Kozma JA. Irreversible enzyme inhibitors. CXXVI. Hydrocarbon interaction with xanthine oxidase by phenyl substituents on purines and pyrazolo[3,4-d]pyrimidines Journal of Medicinal Chemistry. 11: 661-666. PMID 5671224 DOI: 10.1021/Jm00310A006  0.528
1968 Baker BR, Kozma JA. Irreversible enzyme inhibitors. CXXV. Active-site-directed irreversible inhibitors of xanthine oxidase derived from arylpurines and pyrazolo[3,4-d]pyrimidines bearing a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 11: 656-661. PMID 5671223  0.531
1968 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CXIV. Proteolytic enzymes. IV. Additional active-site-directed irreversible inhibitors of α-chymotrypsin derived from phenoxyacetamides bearing a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 11: 241-245. PMID 5654209 DOI: 10.1021/Jm00308A010  0.623
1968 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CXIII. Proteolytic enzymes. III. Active-site-directed irreversible inhibitors of α-chymotrypsin derived from phenoxyacetamides with an N-fluorosulfonylphenyl substituent Journal of Medicinal Chemistry. 11: 233-241. PMID 5654208 DOI: 10.1021/Jm00308A009  0.607
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXXIX. p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. V. Effects of substitution on the benzenesulfonyl fluoride moiety on isozyme specificity Journal of Medicinal Chemistry. 11: 677-682. PMID 5244346  0.556
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXXVIII. p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. IV. Effects of substitution on the propionamide bridge on isozyme specificity Journal of Medicinal Chemistry. 11: 672-677. PMID 5244345  0.564
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXXVII. p-(2,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. III. Effects of modification of the propionamide bridge on isozyme specificity Journal of Medicinal Chemistry. 11: 666-672. PMID 5244344 DOI: 10.1021/Jm00310A007  0.622
1968 Baker BR, Huang PC. Irreversible enzyme inhibitors. CXX. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-substituted 2,4-diamino-5-phenylpyrimidines with tissue specificity Journal of Medicinal Chemistry. 11: 495-500. PMID 5241409  0.535
1968 Baker BR, Meyer RB. Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position. Journal of Medicinal Chemistry. 11: 489-94. PMID 5241408 DOI: 10.1021/Jm00309A018  0.598
1968 Baker BR, Johnson MA. Irreversible enzyme inhibitors. CXVIII. Hydrophobic bonding to dihydrofolic reductase. XII. Further comparisons with the enzyme from Walker 256 rat tumor and rat liver Journal of Medicinal Chemistry. 11: 486-488. PMID 5241407 DOI: 10.1021/Jm00309A017  0.467
1968 Baker BR. Irreversible enzyme inhibitors. CXVII. Hydrophobic bonding to dihydrofolic reductase. XI. Comparison of the enzyme from Walker 256, rat liver, and L1210 mouse leukemia Journal of Medicinal Chemistry. 11: 483-486. PMID 5241406 DOI: 10.1021/Jm00309A016  0.517
1968 Baker BR, Huang PC, Meyer RB. Irreversible enzyme inhibitors. CXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-substituted 2,4-diamino-5-phenylpyrimidines. 3. Journal of Medicinal Chemistry. 11: 475-82. PMID 5241405 DOI: 10.1021/Jm00309A015  0.642
1968 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. II. Journal of Medicinal Chemistry. 11: 38-41. PMID 5237173 DOI: 10.1021/Jm00307A007  0.623
1968 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CXXXI. Cytosine nucleoside deaminase. II. Hydrophobic bonding with disubstituted uracils and cytosines Journal of Medicinal Chemistry. 11: 686-690. PMID 4876444 DOI: 10.1021/Jm00310A011  0.561
1968 Baker BR, Kelley JL. Irreversible enzyme inhibitors. CXXX. Cytosine nucleoside deaminase. I. Hydrophobic bonding with monosubstituted uracils Journal of Medicinal Chemistry. 11: 682-686. PMID 4876443 DOI: 10.1021/Jm00310A010  0.587
1968 Baker BR, Rzeszotarski W. Irreversible enzyme inhibitors. CXXI. Thymidine phosphorylase. IX. On the nature and dimensions of the hydrophobic bonding region Journal of Medicinal Chemistry. 11: 639-644. PMID 4876442  0.467
1968 Baker BR, Wood WF. Irreversible enzyme inhibitors. CXXIII. Candidate irreversible inhibitors of guanine deaminase and xanthine oxidase derived from 9-phenylguanine substituted with a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 11: 650-652. DOI: 10.1021/Jm00310A003  0.647
1968 Baker BR, Wood WF. Irreversible enzyme inhibitors. CXXII. Nature and dimensions of the hydrophobic bonding region of guanine deaminase and xanthine oxidase Journal of Medicinal Chemistry. 11: 644-649. DOI: 10.1021/Jm00310A002  0.552
1968 Baker BR, Erickson EH. Irreversible enzyme inhibitors. CXLIV. Proteolytic enzymes. VII. Additional active-site-directed irreversible inhibitors of trypsin derived from m- and p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride 4 Journal of Medicinal Chemistry. 12: 112-117.  0.558
1968 Baker BR, Vermeulen NMJ. Irreversible enzyme inhibitors. CXXXV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(p-fluorosulfonyl-phenylureido) phenoxymethyl]pyrimidine Journal of Medicinal Chemistry. 12: 79-81.  0.425
1968 Baker BR, Vermeulen NMJ. Irreversible enzyme inhibitors. CXXXVIII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 12: 89-91.  0.572
1968 Baker BR, Kozma JA. Irreversible enzyme inhibitors. CXXIV. Active-site-directed irreversible inhibitors of xanthine oxidase derived from 2- (and 8-) benzylthiopurines bearing a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 11: 652-655.  0.573
1968 Baker BR, Vermeulen NMJ. Irreversible enzyme inhibitors. CXXXIV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonyl-phenylureido) phenoxymethyl]pyrimidine Journal of Medicinal Chemistry. 12: 74-78.  0.431
1968 Baker BR, Erickson EH. Irreversible enzyme inhibitors. CXV. Proteolytic enzymes. V. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride Journal of Medicinal Chemistry. 11: 245-249.  0.57
1968 Baker BR, Wood WF. Irreversible enzyme inhibitors. CXXII. On the nature and dimensions of the hydrophobic bonding region of guanine deaminase and xanthine oxidase Journal of Medicinal Chemistry. 11: 644-649.  0.471
1967 Baker BR, Kawazu M, Santi DV, Schwan TJ. Irreversible Enzyme Inhibitors. LXXVII.(1,2) Inhibitors of Thymidine Phosphorylase. III.(2) Hydrophobic Bonding by 1-Substituted Uracils Containing Additional Substituents at the 5 and 6 Positions. Journal of Medicinal Chemistry. 10: 304-11. PMID 22185119 DOI: 10.1021/Jm00315A003  0.718
1967 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. LXXXVII. Hydrophobic bonding to dihydrofolic reductase. IX. Mode of binding of m-aryloxyalkyl groups on 4,6-diamino-1,2-dihdro-2,2-dimethyl-1-phenyl-s-triazine. Journal of Pharmaceutical Sciences. 56: 871-5. PMID 6068108 DOI: 10.1002/jps.2600560717  0.413
1967 Baker BR, Hurlbut JA. Irreversible enzyme inhibitors. CVII. Proteolytic enzymes. II. Bulk tolerance within chymotrypsin-inhibitor complexes Journal of Medicinal Chemistry. 10: 1129-1133. PMID 6056042 DOI: 10.1021/Jm00318A031  0.592
1967 Baker BR, Kawazu M. Irreversible enzyme inhibitors. 100. Inhibitors of thymidine phosphorylase. 8. 6-(p-Bromoacetamidobenzyl)uracil, an active-site-directed irreversible inhibitor. Journal of Pharmaceutical Sciences. 56: 1086-92. PMID 6049692 DOI: 10.1002/jps.2600560907  0.561
1967 Baker BR, Kawazu M, McClure JD. Irreversible enzyme inhibitors. 99. Inhibitors of thymidine phosphorylase. 7. Further studies on hydrophobic bonding with hydrocarbon substituents on acidic uracils. Journal of Pharmaceutical Sciences. 56: 1081-6. PMID 6049691 DOI: 10.1002/jps.2600560906  0.575
1967 Baker BR, Erickson EH. Irreversible enzyme inhibitors. 98. Hydrophobic interactions with succinoadenylate kinosynthetase and 9-substituted adenines. Journal of Pharmaceutical Sciences. 56: 1075-81. PMID 6049690 DOI: 10.1002/jps.2600560905  0.506
1967 Baker BR, Jackson GD, Meyer RB. Irreversible enzyme inhibitors. LXXXII. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. VII. Derivatives of 2,4-diaminopyrimidine. I. Journal of Pharmaceutical Sciences. 56: 566-70. PMID 6040577 DOI: 10.1002/Jps.2600560504  0.547
1967 Baker BR. Irreversible enzyme inhibitors. 93. Hydrophobic bonding to xanthine oxidase by some phenylpurines. Journal of Pharmaceutical Sciences. 56: 959-62. PMID 6035344 DOI: 10.1002/jps.2600560807  0.51
1967 Baker BR, Meyer RB. Irreversible enzyme inhibitors. LXXXIV. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. IX. Derivatives of 2,4-diaminopyrimidine. 3. Journal of Pharmaceutical Sciences. 56: 570-6. PMID 6032766 DOI: 10.1002/Jps.2600560505  0.626
1967 Baker BR, Santi DV. Irreversible enzyme inhibitors. LXXIV. Inhibitors of guanine deaminase. II. Studies on bulk tolerance within enzyme-inhibitor complexes. Journal of Medicinal Chemistry. 10: 62-4. PMID 6031704 DOI: 10.1021/Jm00313A012  0.714
1967 Baker BR, Schwan TJ, Ho BT. Irreversible enzyme inhibitors. LXXII. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. VI. Derivatives of hydrophobically bonded p-alkyl and p-aralkyl benzoic acids Journal of Pharmaceutical Sciences. 56: 38-42. PMID 6030491 DOI: 10.1002/jps.2600560107  0.552
1967 Baker BR, Shapiro HS. Irreversible enzyme inhibitors. LXXI. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. V. Derivatives of 6-phenylpyrimidine. Journal of Pharmaceutical Sciences. 56: 33-8. PMID 6030490 DOI: 10.1002/jps.2600560106  0.554
1967 Baker BR, Ho BT. Irreversible enzyme inhibitors. LXX. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. IV. Substituted 1-phenyl-1,2-dihydro-s-triazines Journal of Pharmaceutical Sciences. 56: 28-32. PMID 6030489 DOI: 10.1002/Jps.2600560105  0.55
1967 Baker BR, Shapiro HS. Analogs of tetrahydrofolic acid 34. Hydrophobic bonding to dihydrofolic reductase VI. Mode of phenyl binding of some 6-arylpyrimidines. Journal of Pharmaceutical Sciences. 55: 308-17. PMID 5960177 DOI: 10.1002/Jps.2600550309  0.357
1967 Baker BR, Schwan TJ. Nonclassical antimetabolites. XXVI. Inhibitors of thymidine kinase. II. Inhibition by functionalized 1-alkyluracils. Journal of Medicinal Chemistry. 9: 73-6. PMID 5958965 DOI: 10.1021/Jm00319A019  0.418
1967 Baker BR, Lourens GJ. Irreversible enzyme inhibitors. CIX. Candidate irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1l,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine. III Journal of Medicinal Chemistry. 11: 26-33. PMID 5237171 DOI: 10.1021/Jm00307A005  0.593
1967 Baker BR, Ho BT, Lourens GJ. Irreversible enzyme inhibitors. LXXXVI. Hydrophobic bonding to dihydrofolic reductase. 8. Substituted-1-aryl-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines Journal of Pharmaceutical Sciences. 56: 737-742. PMID 5231391 DOI: 10.1002/Jps.2600560616  0.49
1967 Baker BR, Kawazu M. Irreversible enzyme inhibitors. LXXIX.1,2 inhibitors of thymidine phosphorylase. V.2 mode of pyrimidine binding Journal of Medicinal Chemistry. 10: 313-315. DOI: 10.1021/Jm00315A005  0.557
1967 Baker BR, Kawazu M. Irreversible enzyme inhibitors. LXXVIII.1,2 inhibitors of thymidine phosphorylase. IV.2 hydrophobic bonding by uracils substituted at the 5 and 6 positions Journal of Medicinal Chemistry. 10: 311-313. DOI: 10.1021/Jm00315A004  0.615
1967 Baker B, Santi DV. Irreversible Enzyme Inhibitors LXIX Journal of Pharmaceutical Sciences. 56: 380-384. DOI: 10.1002/Jps.2600560315  0.663
1967 Baker BR, Coward JK. Irreversible enzyme inhibitors. LXXXIX. candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. X. derivatives of 2-amino-5-benzamidopropyl-4-pyrimidinol Journal of Heterocyclic Chemistry. 4: 188-194. DOI: 10.1002/Jhet.5570040205  0.729
1967 Baker BR, Kawazu M, Santi DV, Schwan TJ. Irreversible enzyme inhibitors. LXXVII. 1,2 inhibitors of thymidine phosphorylase. III. 2 hydrophobie bonding by I-substituted uracils containing additional substituents at the 5 and 6 positions Journal of Medicinal Chemistry. 10: 304-311.  0.544
1967 Baker BR. Irreversible enzyme inhibitors. LXXV. 1,2 inhibitors of thymidine phosphorylase. I. Mode of ribofuranose binding Journal of Medicinal Chemistry. 10: 297-301.  0.482
1966 Baker BR, Ho BT, Coward JK, Santi DV. Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid. Journal of Pharmaceutical Sciences. 55: 302-8. PMID 5960176 DOI: 10.1002/Jps.2600550308  0.679
1966 Baker BR, Schwan TJ, Novotny J, Ho BT. Analogs of tetrahydrofolic acid. 32. Hydrophobic bonding to dihydrofolic reductase IV. Inhibition by p-substituted benzoic and benzoyl-L-glutamic acids Journal of Pharmaceutical Sciences. 55: 295-302. PMID 5960175 DOI: 10.1002/jps.2600550307  0.313
1966 Baker BR, Schwan TJ, Santi DV. Nonclassical antimetabolites. XXV. Inhibitors of thymidine kinase. I. A new spectrophotometric assay. Inhibition by nucleoside derivatives. Journal of Medicinal Chemistry. 9: 66-72. PMID 4225176 DOI: 10.1021/Jm00319A018  0.608
1966 Baker BR, Ho B. Analogs of tetrahydrofolic acid XXXV. Hydrophobic bonding to dihydrofolic reductase VII. Species differences with substituted 4,6‐diamino‐1,2‐dihydro‐s‐triazines Journal of Pharmaceutical Sciences. 55: 470-474. DOI: 10.1002/Jps.2600550504  0.547
1966 Baker BR, Santi DV, Coward JK, Shapiro HS, Jordaan JH. Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitors Journal of Heterocyclic Chemistry. 3: 425-434. DOI: 10.1002/Jhet.5570030407  0.668
1965 Baker BR, Beng-Thong Ho, Santi DV. Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines. Journal of Pharmaceutical Sciences. 54: 1415-24. PMID 5883214 DOI: 10.1002/jps.2600541005  0.53
1965 Baker BR, Ho BT. Analogs of tetrahydrofolic acid XX. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol on inhibition of dihydrofolic reductase and thymidylate synthetase II Journal of Pharmaceutical Sciences. 54: 1187-1190. PMID 5882225 DOI: 10.1002/jps.2600540820  0.363
1965 Baker BR, Ho BT. Analogs of tetrahydrofolic acid XXV. 2,4-Diamino-6-phenethylpteridine, an inhibitor of dihydrofolic reductase Journal of Pharmaceutical Sciences. 54: 1261-1265. PMID 5881216 DOI: 10.1002/Jps.2600540907  0.553
1965 Baker BR, Santi DV. Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor. Journal of Pharmaceutical Sciences. 54: 1252-7. PMID 5881214 DOI: 10.1002/jps.2600540905  0.579
1965 Baker BR, Coward JK. Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol thymidylate synthetase. 3. Journal of Pharmaceutical Sciences. 54: 714-9. PMID 5847011 DOI: 10.1002/Jps.2600540511  0.603
1965 Baker BR, Lourens GJ. Analogs of tetrahydrofolic acid. XXXI. Hydrophobic bonding to dihydrofolic reductase. III. Further observations on conformational aspects of hydrophobic bonding with some 5-alkyl-2,4-diamino-6-pyrimidinols Journal of Heterocyclic Chemistry. 2: 344-347. DOI: 10.1002/Jhet.5570020404  0.434
1965 Baker BR, Ho B. Analogs of tetrahydrofolic acid. XXIII. 1-(ω-phenylalkyl)-4,6-diamino-1,2-dihydro-s-triazines as inhibitors of dihydrofolic reductase†‡ Journal of Heterocyclic Chemistry. 2: 72-79. DOI: 10.1002/Jhet.5570020113  0.566
1964 BAKER BR, SANTI DV, SHAPIRO HS. ANALOGS OF TETRAHYDROFOLIC ACID. XIV. FACILE SYNTHETIC ROUTE TO THE 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE INHIBITOR. Journal of Pharmaceutical Sciences. 53: 1317-25. PMID 14253585 DOI: 10.1002/jps.2600531107  0.595
1964 BAKER BR, SANTI DV, ALMAULA PI, WERKEISER WC. ANALOGS OF TETRAHYDROFOLIC ACID. X. SYNTHETIC AND ENZYMIC STUDIES ON THE CONTRIBUTION OF THE P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES. Journal of Medicinal Chemistry. 7: 24-30. PMID 14186020 DOI: 10.1021/Jm00331A007  0.649
1963 Baker BR, Morreal CE, Ho BT. Analogs of tetrahydrofolic acid. VIII. Synthesis of N-[1-(2-amino-4-mercapto-6-methyl-5-pyrimidyl)-3-propyl]-p-aminobenzoyl-L- glutamic acid, a mercapto analog Journal of Medicinal Chemistry. 6: 658-664. PMID 14184921 DOI: 10.1021/Jm00342A008  0.379
1962 Baker BR, Almaula PI. Nonclassical Antimetabolites. X.1,2 A Facile Synthesis of 4-Quinazolone-2-carboxylic Acid and the Structure of Bogert's Ammonium Salt Journal of Organic Chemistry. 27: 4672-4674. DOI: 10.1021/Jo01059A524  0.314
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