Joshua R. Sacher, Ph.D. - Publications

Affiliations: 
2014- Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard, USA 
Area:
chemistry, synthesis, organic chemistry, medicinal chemistry, neuroscience

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Reidenbach AG, Mesleh MF, Casalena D, Vallabh SM, Dahlin JL, Leed AJ, Chan AI, Usanov DL, Yehl JB, Lemke CT, Campbell AJ, Shah RN, Shrestha OK, Sacher JR, Rangel VL, et al. Multimodal small-molecule screening for human prion protein binders. The Journal of Biological Chemistry. PMID 32723867 DOI: 10.1074/Jbc.Ra120.014905  0.01
2020 Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, Stanulla M, Yuan C, Sicinska E, Giannakis M, Ng K, et al. Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discovery. PMID 32703769 DOI: 10.1158/2159-8290.Cd-19-1472  0.01
2019 Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, et al. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 35: 664-676.e7. PMID 30991026 DOI: 10.1016/J.Ccell.2019.03.004  0.01
2018 Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine. 10. PMID 29515000 DOI: 10.1126/Scitranslmed.Aam8460  0.04
2018 Weiwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, Đorđević L, Sacher JR, Skepner A, Fei D, Dennehy K, et al. Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology. PMID 29485852 DOI: 10.1021/Acschembio.8B00168  0.08
2017 Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo (Athens, Greece). 31: 39-43. PMID 28064218 DOI: 10.21873/Invivo.11022  1
2016 Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. Acs Central Science. 2: 653-659. PMID 27725964 DOI: 10.1021/Acscentsci.6B00199  1
2016 Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weiwer M, An WF, ... ... Sacher JR, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology. PMID 27128528 DOI: 10.1021/Acschembio.6B00306  1
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 26159482 DOI: 10.1016/J.Bmcl.2015.06.073  1
2015 Chauhan PS, Sacher JR, Weinreb SM. Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence. Organic Letters. 17: 806-8. PMID 25658603 DOI: 10.1021/Ol503571A  1
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.06.073  1
2014 Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Journal of Molecular and Cellular Cardiology. 77: 136-46. PMID 25451170 DOI: 10.1016/J.Yjmcc.2014.10.009  1
2014 Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P. An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. Acs Medicinal Chemistry Letters. 5: 900-4. PMID 25147611 DOI: 10.1021/Ml5001504  1
2014 Sacher JR, Weinreb SM. DISCUSSION ADDENDUM for: 2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl) Organic Syntheses. 34-43. DOI: 10.1002/0471264229.Os089.03  1
2013 Frantz MC, Skoda EM, Sacher JR, Epperly MW, Goff JP, Greenberger JS, Wipf P. Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & Biomolecular Chemistry. 11: 4147-53. PMID 23715589 DOI: 10.1039/C3Ob40489G  1
2012 Sacher JR, Weinreb SM. Construction of the azocane (azacyclooctane) moiety of the Lycopodium alkaloid lycopladine H via an intramolecular hydroaminomethylation strategy. Organic Letters. 14: 2172-5. PMID 22486178 DOI: 10.1021/Ol3007277  1
2011 Sacher JR, Weinreb SM. Exploratory studies towards a total synthesis of the unusual bridged tetracyclic Lycopodium alkaloid lycopladine H. Tetrahedron. 67: 10203-10207. PMID 22125345 DOI: 10.1016/J.Tet.2011.04.016  1
2009 Evans MA, Sacher JR, Weinreb SM. Exploratory studies toward a total synthesis of the marine ascidian metabolite perophoramidine Tetrahedron. 65: 6712-6719. DOI: 10.1016/J.Tet.2008.10.060  1
2007 Stry S, Sacher JR. Widely tunable ultra stable 1W two color THz laser source Proceedings of Spie - the International Society For Optical Engineering. 6472. DOI: 10.1117/12.701951  1
2004 Hildebrandt L, Stry S, Knispel R, Sacher JR, Mann C, Fuchs F. Quantum cascade external cavity laser systems in the mid-infrared spectral range Osa Trends in Optics and Photonics Series. 96: 773-774.  1
2003 Hildebrandt L, Knispel R, Stry S, Sacher JR, Schael F. Antireflection-coated blue GaN laser diodes in an external cavity and Doppler-free indium absorption spectroscopy. Applied Optics. 42: 2110-8. PMID 12716152  1
2003 Hildebrandt L, Knispel R, Stry S, Sacher JR. Optimization of the antireflection coating of blue GaN laser diodes and their characterization in an external cavity in Littrow and Littman-Metcalf configuration Conference On Lasers and Electro-Optics Europe - Technical Digest. 184. DOI: 10.1109/CLEOE.2003.1312245  1
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