Christine A. Hrycyna, Ph.D. - Publications

2000- Chemistry Purdue University, West Lafayette, IN, United States 
multidrug resistance in human cancer

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Vervacke JS, Funk AL, Wang YC, Strom M, Hrycyna CA, Distefano MD. Diazirine-containing photoactivatable isoprenoid: synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase. The Journal of Organic Chemistry. 79: 1971-8. PMID 24502619 DOI: 10.1021/jo402600b  1
2014 Emmert D, Campos CR, Ward D, Lu P, Namanja HA, Bohn K, Miller DS, Sharom FJ, Chmielewski J, Hrycyna CA. Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. Acs Chemical Neuroscience. 5: 305-17. PMID 24483607 DOI: 10.1021/cn4002329  1
2014 Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE. Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. Acs Chemical Biology. 9: 722-30. PMID 24369685 DOI: 10.1021/cb4008953  1
2013 Namanja HA, Emmert D, Hrycyna CA, Chmielewski J. Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length. Medchemcomm. 4. PMID 24273637 DOI: 10.1039/C3MD00196B  1
2013 Thompson KV, Chmielewski J, Gaines MS, Hrycyna CA, LaCourse WR. Competency-based reforms of the undergraduate biology curriculum: integrating the physical and biological sciences. Cbe Life Sciences Education. 12: 162-9. PMID 23737624 DOI: 10.1187/cbe.12-09-0143  1
2013 Michaelis S, Hrycyna CA. Biochemistry. A protease for the ages. Science (New York, N.Y.). 339: 1529-30. PMID 23539586 DOI: 10.1126/science.1236764  1
2012 Chmielewski J, Hrycyna C. Research spotlight: Tools for eradicating HIV in the brain: Prodrug dimeric inhibitors of P-gp Therapeutic Delivery. 3: 689-692. PMID 22838065 DOI: 10.4155/tde.12.49  1
2012 Bergman JA, Hahne K, Song J, Hrycyna CA, Gibbs RA. S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase. Acs Medicinal Chemistry Letters. 3: 15-19. PMID 22754607 DOI: 10.1021/ml200106d  1
2012 Barrowman J, Wiley PA, Hudon-Miller SE, Hrycyna CA, Michaelis S. Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity. Human Molecular Genetics. 21: 4084-93. PMID 22718200 DOI: 10.1093/hmg/dds233  1
2012 Hahne K, Vervacke JS, Shrestha L, Donelson JL, Gibbs RA, Distefano MD, Hrycyna CA. Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes. Biochemical and Biophysical Research Communications. 423: 98-103. PMID 22634004 DOI: 10.1016/j.bbrc.2012.05.089  1
2012 Kuriakose J, Hrycyna CA, Chmielewski J. Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux. Bioorganic & Medicinal Chemistry Letters. 22: 4410-2. PMID 22632934 DOI: 10.1016/j.bmcl.2012.04.125  1
2012 Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. Journal of Lipid Research. 53: 1176-82. PMID 22448028 DOI: 10.1194/jlr.M026161  1
2012 Majmudar JD, Hodges-Loaiza HB, Hahne K, Donelson JL, Song J, Shrestha L, Harrison ML, Hrycyna CA, Gibbs RA. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorganic & Medicinal Chemistry. 20: 283-95. PMID 22142613 DOI: 10.1016/j.bmc.2011.10.087  1
2012 Namanja HA, Emmert D, Davis DA, Campos C, Miller DS, Hrycyna CA, Chmielewski J. Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers. Journal of the American Chemical Society. 134: 2976-80. PMID 21866921 DOI: 10.1021/ja206867t  1
2012 Majmudar JD, Morrison-Logue A, Song J, Hrycyna CA, Gibbs RA. Identification of a novel nanomolar inhibitor of hIcmt via a carboxylate replacement approach Medchemcomm. 3: 1125-1137. DOI: 10.1039/c2md20108a  1
2011 Bergman JA, Hahne K, Hrycyna CA, Gibbs RA. Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5616-9. PMID 21782433 DOI: 10.1016/j.bmcl.2011.06.053  1
2011 Jacobs A, Emmert D, Wieschrath S, Hrycyna CA, Wiese M. Recombinant synthesis of human ABCG2 expressed in the yeast Saccharomyces cerevisiae: an experimental methodological study. The Protein Journal. 30: 201-11. PMID 21424391 DOI: 10.1007/s10930-011-9321-5  1
2011 Majmudar JD, Hahne K, Hrycyna CA, Gibbs RA. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2616-20. PMID 21334890 DOI: 10.1016/j.bmcl.2011.01.078  1
2011 Bergman JA, Majmudar JD, Gibbs RA, Hrycyna CA. Inhibitors of Postprenylation CAAX Processing Enzymes Enzymes. 30: 205-229. DOI: 10.1016/B978-0-12-415922-8.00009-4  1
2011 Court H, Hahne K, Philips MR, Hrycyna CA. Biochemical and Biological Functions of Isoprenylcysteine Carboxyl Methyltransferase Enzymes. 30: 71-90. DOI: 10.1016/B978-0-12-415922-8.00004-5  1
2011 Tamanoi F, Hrycyna CA, Bergo MO. Preface Enzymes. 29: xi-xii. DOI: 10.1016/B978-0-12-381339-8.00021-4  1
2010 Griggs AM, Hahne K, Hrycyna CA. Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p. The Journal of Biological Chemistry. 285: 13380-7. PMID 20202940 DOI: 10.1074/jbc.M109.061366  1
2009 Namanja HA, Emmert D, Pires MM, Hrycyna CA, Chmielewski J. Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer. Biochemical and Biophysical Research Communications. 388: 672-6. PMID 19683513 DOI: 10.1016/j.bbrc.2009.08.056  1
2009 Donelson JL, Hodges-Loaiza HB, Henriksen BS, Hrycyna CA, Gibbs RA. Solid-phase synthesis of prenylcysteine analogs. The Journal of Organic Chemistry. 74: 2975-81. PMID 19320430 DOI: 10.1021/jo8021692  1
2009 Pires MM, Emmert D, Hrycyna CA, Chmielewski J. Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers. Molecular Pharmacology. 75: 92-100. PMID 18945821 DOI: 10.1124/mol.108.050492  1
2008 Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochemical and Biophysical Research Communications. 374: 365-8. PMID 18639527 DOI: 10.1016/j.bbrc.2008.07.033  1
2008 Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. The Journal of Biological Chemistry. 283: 9797-804. PMID 18230615 DOI: 10.1074/jbc.M709629200  1
2007 Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 13432-7. PMID 17652517 DOI: 10.1073/pnas.0704212104  1
2007 Takenaka K, Morgan JA, Scheffer GL, Adachi M, Stewart CF, Sun D, Leggas M, Ejendal KF, Hrycyna CA, Schuetz JD. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Research. 67: 6965-72. PMID 17638908 DOI: 10.1158/0008-5472.CAN-06-4720  1
2006 Anderson JL, Hrycyna CA. 9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing. The Enzymes. 24: 245-72. PMID 26718043 DOI: 10.1016/S1874-6047(06)80011-9  0.68
2006 Febo-Ayala W, Morera-Félix SL, Hrycyna CA, Thompson DH. Functional reconstitution of the integral membrane enzyme, isoprenylcysteine carboxyl methyltransferase, in synthetic bolalipid membrane vesicles. Biochemistry. 45: 14683-94. PMID 17144661 DOI: 10.1021/bi061159c  1
2006 Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology. 2: 518-28. PMID 16983387 DOI: 10.1038/nchembio818  1
2006 Pires MM, Hrycyna CA, Chmielewski J. Bivalent probes of the human multidrug transporter P-glycoprotein. Biochemistry. 45: 11695-702. PMID 16981729 DOI: 10.1021/bi0608109  1
2006 Ejendal KF, Diop NK, Schweiger LC, Hrycyna CA. The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding. Protein Science : a Publication of the Protein Society. 15: 1597-607. PMID 16815914 DOI: 10.1110/ps.051998406  1
2006 Donelson JL, Hodges HB, Macdougall DD, Henriksen BS, Hrycyna CA, Gibbs RA. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorganic & Medicinal Chemistry Letters. 16: 4420-3. PMID 16777414 DOI: 10.1016/j.bmcl.2006.05.029  1
2006 Anderson JL, Hrycyna CA. 9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing Enzymes. 24: 245-272. DOI: 10.1016/S1874-6047(06)80011-9  1
2005 Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A, Titapiwatanakun B, Peer WA, Bailly A, Richards EL, Ejendal KF, Smith AP, Baroux C, Grossniklaus U, Müller A, ... Hrycyna CA, et al. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. The Plant Journal : For Cell and Molecular Biology. 44: 179-94. PMID 16212599 DOI: 10.1111/j.1365-313X.2005.02519.x  1
2005 Henriksen BS, Anderson JL, Hrycyna CA, Gibbs RA. Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity. Bioorganic & Medicinal Chemistry Letters. 15: 5080-3. PMID 16183278 DOI: 10.1016/j.bmcl.2005.07.075  1
2005 Bhatia A, Schäfer HJ, Hrycyna CA. Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers. Biochemistry. 44: 10893-904. PMID 16086592 DOI: 10.1021/bi0503807  1
2005 Anderson JL, Henriksen BS, Gibbs RA, Hrycyna CA. The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors. The Journal of Biological Chemistry. 280: 29454-61. PMID 15946942 DOI: 10.1074/jbc.M504982200  1
2005 Tarasova NI, Seth R, Tarasov SG, Kosakowska-Cholody T, Hrycyna CA, Gottesman MM, Michejda CJ. Transmembrane inhibitors of P-glycoprotein, an ABC transporter. Journal of Medicinal Chemistry. 48: 3768-75. PMID 15916428 DOI: 10.1021/jm049065t  1
2005 Hodges HB, Zhou M, Haldar S, Anderson JL, Thompson DH, Hrycyna CA. Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator. Bioconjugate Chemistry. 16: 490-3. PMID 15898712 DOI: 10.1021/bc050027d  1
2005 Wang C, Leffler S, Thompson DH, Hrycyna CA. A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases. Biochemical and Biophysical Research Communications. 331: 351-6. PMID 15845399 DOI: 10.1016/j.bbrc.2005.03.170  1
2005 Diop NK, Hrycyna CA. N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane. Biochemistry. 44: 5420-9. PMID 15807535 DOI: 10.1021/bi0479858  1
2005 Anderson JL, Frase H, Michaelis S, Hrycyna CA. Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p. The Journal of Biological Chemistry. 280: 7336-45. PMID 15611058 DOI: 10.1074/jbc.M410292200  1
2005 Ejendal KF, Hrycyna CA. Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A. Molecular Pharmacology. 67: 902-11. PMID 15598974 DOI: 10.1124/mol.104.001701  1
2005 Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. The Biochemical Journal. 387: 129-38. PMID 15479156 DOI: 10.1042/BJ20041359  1
2002 Ejendal KF, Hrycyna CA. Multidrug resistance and cancer: the role of the human ABC transporter ABCG2. Current Protein & Peptide Science. 3: 503-11. PMID 12369998 DOI: 10.2174/1389203023380521  1
2001 Hrycyna CA. Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance. Seminars in Cell & Developmental Biology. 12: 247-56. PMID 11428917 DOI: 10.1006/scdb.2000.0250  1
2000 Lamensdorf I, Hrycyna C, He LP, Nechushtan A, Tjurmina O, Harvey-White J, Eisenhofer G, Rojas E, Kopin IJ. Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter. Naunyn-Schmiedeberg's Archives of Pharmacology. 361: 654-64. PMID 10882041 DOI: 10.1007/s002100000246  1
2000 Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, Ambudkar SV. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system. The Journal of Membrane Biology. 173: 203-14. PMID 10667916 DOI: 10.1007/s002320001020  1
1999 Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry. 38: 13887-99. PMID 10529234 DOI: 10.1021/bi991115m  1
1999 Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annual Review of Pharmacology and Toxicology. 39: 361-98. PMID 10331089 DOI: 10.1146/annurev.pharmtox.39.1.361  1
1998 Hrycyna CA, Gottesman MM. Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 1: 81-3. PMID 16904390 DOI: 10.1016/S1368-7646(98)80019-8  1
1998 Hafkemeyer P, Dey S, Ambudkar SV, Hrycyna CA, Pastan I, Gottesman MM. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein. Biochemistry. 37: 16400-9. PMID 9819232 DOI: 10.1021/bi980871+  1
1998 Russ G, Ramachandra M, Hrycyna CA, Gottesman MM, Pastan I, Bennink JR, Yewdell JW. P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells. Cancer Research. 58: 4688-93. PMID 9788623  1
1998 Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 37: 13660-73. PMID 9753453 DOI: 10.1021/bi9808823  1
1998 Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods in Enzymology. 292: 456-73. PMID 9711574 DOI: 10.1016/S0076-6879(98)92035-3  1
1998 Hrycyna CA, Ramachandra M, Ambudkar SV, Ko YH, Pedersen PL, Pastan I, Gottesman MM. Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites. The Journal of Biological Chemistry. 273: 16631-4. PMID 9642211 DOI: 10.1074/jbc.273.27.16631  1
1998 Ramachandra M, Ambudkar SV, Chen D, Hrycyna CA, Dey S, Gottesman MM, Pastan I. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry. 37: 5010-9. PMID 9538020 DOI: 10.1021/bi973045u  1
1996 Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular Biology of the Cell. 7: 1485-98. PMID 8898356  1
1996 Hwang M, Ahn CH, Pine PS, Yin JJ, Hrycyna CA, Licht T, Aszalos A. Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells. International Journal of Cancer. Journal International Du Cancer. 65: 389-97. PMID 8575863 DOI: 10.1002/(SICI)1097-0215(19960126)65:3<389::AID-IJC19>3.0.CO;2-5  1
1995 Sugimoto Y, Hrycyna CA, Aksentijevich I, Pastan I, Gottesman MM. Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 1: 447-57. PMID 9816003  1
1995 Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. Genetic analysis of the multidrug transporter. Annual Review of Genetics. 29: 607-49. PMID 8825488 DOI: 10.1146/  1
1995 Hrycyna CA, Wait SJ, Backlund PS, Michaelis S. Yeast STE14 methyltransferase, expressed as TrpE-STE14 fusion protein in Escherichia coli, for in vitro carboxylmethylation of prenylated polypeptides. Methods in Enzymology. 250: 251-66. PMID 7651156 DOI: 10.1016/0076-6879(95)50077-4  1
1995 Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM. Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus. Journal of Bioenergetics and Biomembranes. 27: 43-52. PMID 7629051 DOI: 10.1007/BF02110330  1
1994 Hrycyna CA, Yang MC, Clarke S. Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways. Biochemistry. 33: 9806-12. PMID 8068661  1
1993 Hrycyna CA, Clarke S. Modification of eukaryotic signaling proteins by C-terminal methylation reactions. Pharmacology & Therapeutics. 59: 281-300. PMID 8309992 DOI: 10.1016/0163-7258(93)90071-K  1
1993 Hrycyna CA, Clarke S. Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry. 32: 11293-301. PMID 8218194 DOI: 10.1021/bi00093a005  1
1992 Hrycyna CA, Clarke S. Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro. The Journal of Biological Chemistry. 267: 10457-64. PMID 1587828  1
1991 Hrycyna CA, Sapperstein SK, Clarke S, Michaelis S. The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. The Embo Journal. 10: 1699-709. PMID 2050108  1
1990 Hrycyna CA, Clarke S. Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Molecular and Cellular Biology. 10: 5071-6. PMID 2204804  1
1988 Quelle FW, Smith RV, Hrycyna CA, Kaliban TD, Crooks JA, O'Brien JM. [3H]dexamethasone binding to plasma membrane-enriched fractions from liver of nonadrenalectomized rats. Endocrinology. 123: 1642-51. PMID 2841103 DOI: 10.1210/endo-123-3-1642  1
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