Andrew D. Mesecar - Publications

Affiliations: 
Molecular Biosciences Purdue University, West Lafayette, IN, United States 
Area:
molecular mechanisms and function of therapeutic enzymes and proteins
Website:
http://www.chem.purdue.edu/people/faculty/faculty.asp?itemID=91

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ghosh AK, Raghavaiah J, Shahabi D, Yadav M, Anson BJ, Lendy EK, Hattori SI, Higashi-Kuwata N, Mitsuya H, Mesecar AD. Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of Medicinal Chemistry. PMID 34528437 DOI: 10.1021/acs.jmedchem.1c01214  1
2021 Minasov G, Rosas-Lemus M, Shuvalova L, Inniss NL, Brunzelle JS, Daczkowski CM, Hoover P, Mesecar AD, Satchell KJF. Mn coordinates Cap-0-RNA to align substrates for efficient 2'--methyl transfer by SARS-CoV-2 nsp16. Science Signaling. 14. PMID 34131072 DOI: 10.1126/scisignal.abh2071  1
2021 Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, ... ... Mesecar AD, et al. Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit. The Journal of Infectious Diseases. PMID 34111271 DOI: 10.1093/infdis/jiab305  1
2021 Yen YC, Kammeyer AM, Tirlangi J, Ghosh AK, Mesecar AD. A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. Acs Chemical Neuroscience. PMID 33544569 DOI: 10.1021/acschemneuro.0c00629  1
2021 Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, ... ... Mesecar AD, et al. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Communications. 12: 668. PMID 33510133 DOI: 10.1038/s41467-021-20900-6  1
2020 Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond J, Hoffman R, Kadar EP, Kania R, Kimoto E, ... ... Mesecar AD, et al. Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19. Biorxiv : the Preprint Server For Biology. PMID 32935104 DOI: 10.1101/2020.09.12.293498  1
2020 Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, ... ... Mesecar AD, et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. PMID 32707573 DOI: 10.1038/S41586-020-2577-1  1
2020 Ghosh AK, Brindisi M, Shahabi D, Chapman ME, Mesecar AD. Drug Development and Medicinal Chemistry Efforts Toward SARS-Coronavirus and Covid-19 Therapeutics. Chemmedchem. PMID 32324951 DOI: 10.1002/Cmdc.202000223  1
2020 Deng X, Chen Y, Mielech AM, Hackbart M, Kesely KR, Mettelman RC, O'Brien A, Chapman ME, Mesecar AD, Baker SC. Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus. Journal of Virology. PMID 32188728 DOI: 10.1128/Jvi.01734-19  1
2019 Clasman JR, Everett RK, Srinivasan K, Mesecar AD. Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease. Antiviral Research. 104661. PMID 31765674 DOI: 10.1016/j.antiviral.2019.104661  1
2019 Yen YC, Kammeyer A, Jensen KC, Tirlangi J, Ghosh AK, Mesecar AD. Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors. Biochemistry. PMID 31549827 DOI: 10.1021/Acs.Biochem.9B00714  1
2019 Zhang H, Li Z, Daczkowski CM, Gabel C, Mesecar AD, Chang L. Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins. Cell Host & Microbe. PMID 31155345 DOI: 10.1016/j.chom.2019.05.004  1
2019 Vickman RE, Yang J, Lanman NA, Cresswell GM, Zheng F, Zhang C, Doerge RW, Crist SA, Mesecar AD, Hu CD, Ratliff TL. Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNF alpha in Castration Resistant Prostate Cancer. Molecular Cancer Research : McR. PMID 30824526 DOI: 10.1158/1541-7786.Mcr-18-1054  1
2019 Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. Chemmedchem. PMID 30637955 DOI: 10.1002/Cmdc.201800725  1
2018 Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. PMID 29970308 DOI: 10.1016/J.Bmcl.2018.06.045  1
2017 Abuhammad A, Al-Aqtash RA, Anson BJ, Mesecar AD, Taha MO. Computational modeling of the bat HKU4 coronavirus 3CL(pro) inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus. Journal of Molecular Recognition : Jmr. PMID 28608547 DOI: 10.1002/jmr.2644  1
2017 Daczkowski CM, Dzimianski JV, Clasman JR, Goodwin O, Mesecar AD, Pegan SD. Structural insights into the interaction of coronavirus papain-like proteases and interferon-stimulated gene product 15 from different species. Journal of Molecular Biology. PMID 28438633 DOI: 10.1016/J.Jmb.2017.04.011  1
2017 Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28427814 DOI: 10.1016/J.Bmcl.2017.04.011  1
2017 Clasman JR, Báez-Santos YM, Mettelman RC, O'Brien A, Baker SC, Mesecar AD. X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design. Scientific Reports. 7: 40292. PMID 28079137 DOI: 10.1038/srep40292  1
2016 Hjortland NM, Mesecar AD. Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme. Archives of Biochemistry and Biophysics. 612: 35-45. PMID 27756680 DOI: 10.1016/J.Abb.2016.10.008  0.01
2016 Ghosh AK, Reddy BS, Yen YC, Cardenas E, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chemical Science (Royal Society of Chemistry : 2010). 7: 3117-3122. PMID 27347366 DOI: 10.1039/C5Sc03718B  1
2016 Vickman RE, Crist SA, Kerian K, Eberlin L, Cooks RG, Burcham GN, Buhman KK, Hu CD, Mesecar AD, Cheng L, Ratliff TL. Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer. Molecular Cancer Research : McR. PMID 27341831 DOI: 10.1158/1541-7786.Mcr-16-0137  1
2016 St John SE, Anson BJ, Mesecar AD. X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus. Scientific Reports. 6: 25961. PMID 27173881 DOI: 10.1038/srep25961  1
2015 St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. Bioorganic & Medicinal Chemistry Letters. 25: 5072-7. PMID 26592814 DOI: 10.1016/J.Bmcl.2015.10.023  1
2015 Jain AD, Potteti H, Richardson BG, Kingsley L, Luciano JP, Ryuzoji AF, Lee H, Krunic A, Mesecar AD, Reddy SP, Moore TW. Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. European Journal of Medicinal Chemistry. 103: 252-268. PMID 26363505 DOI: 10.1016/J.Ejmech.2015.08.049  1
2015 Chen Y, Savinov SN, Mielech AM, Cao T, Baker SC, Mesecar AD. X-ray Structural and Functional Studies of the Three Tandemly-Linked Domains of Nsp3 from Murine Hepatitis Virus Reveal Conserved Functions. The Journal of Biological Chemistry. PMID 26296883 DOI: 10.1074/Jbc.M115.662130  1
2015 St John SE, Tomar S, Stauffer SR, Mesecar AD. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorganic & Medicinal Chemistry. 23: 6036-48. PMID 26190463 DOI: 10.1016/j.bmc.2015.06.039  1
2015 Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced dimerization of MERS coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals. The Journal of Biological Chemistry. PMID 26055715 DOI: 10.1074/Jbc.M115.651463  1
2015 Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC. Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis. Journal of Virology. 89: 4907-17. PMID 25694594 DOI: 10.1128/Jvi.00338-15  1
2015 Báez-Santos YM, St John SE, Mesecar AD. The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Research. 115: 21-38. PMID 25554382 DOI: 10.1016/J.Antiviral.2014.12.015  1
2015 Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. 25: 668-72. PMID 25537272 DOI: 10.1016/J.Bmcl.2014.11.087  1
2015 St. John SE, Tomar S, Stauffer SR, Mesecar AD. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4-The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS) Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2015.06.039  1
2014 Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD. Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. Journal of Virology. 88: 12511-27. PMID 25142582 DOI: 10.1128/Jvi.01294-14  1
2014 Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. Journal of Virology. 88: 11825-33. PMID 25100850 DOI: 10.1128/Jvi.01749-14  1
2014 Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. Journal of Virology. 88: 11886-98. PMID 25100843 DOI: 10.1128/Jvi.01528-14  1
2014 Zhai X, Go MK, O'Donoghue AC, Amyes TL, Pegan SD, Wang Y, Loria JP, Mesecar AD, Richard JP. Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501. PMID 24825099 DOI: 10.1021/Bi500458T  1
2014 Molland K, Zhou Q, Mesecar AD. A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding. Acta Crystallographica. Section F, Structural Biology Communications. 70: 283-7. PMID 24598911 DOI: 10.1107/S2053230X14002519  1
2014 Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. Journal of Medicinal Chemistry. 57: 2393-412. PMID 24568342 DOI: 10.1021/Jm401712T  1
2014 Mielech AM, Chen Y, Mesecar AD, Baker SC. Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Research. 194: 184-90. PMID 24512893 DOI: 10.1016/J.Virusres.2014.01.025  1
2014 Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC. MERS-CoV papain-like protease has deISGylating and deubiquitinating activities. Virology. 450: 64-70. PMID 24503068 DOI: 10.1016/J.Virol.2013.11.040  1
2014 Lv W, Banerjee B, Molland KL, Seleem MN, Ghafoor A, Hamed MI, Wan B, Franzblau SG, Mesecar AD, Cushman M. Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase. Bioorganic & Medicinal Chemistry. 22: 406-18. PMID 24315189 DOI: 10.1016/J.Bmc.2013.11.011  1
2013 Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR. Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters. 23: 6172-7. PMID 24080461 DOI: 10.1016/J.Bmcl.2013.08.112  1
2013 Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. Journal of Virology. 87: 12611-8. PMID 24027335 DOI: 10.1128/Jvi.02050-13  1
2013 St John SE, Jensen KC, Kang S, Chen Y, Calamini B, Mesecar AD, Lipton MA. Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorganic & Medicinal Chemistry. 21: 6022-37. PMID 23953689 DOI: 10.1016/J.Bmc.2013.07.037  1
2013 Pegan SD, Rukseree K, Capodagli GC, Baker EA, Krasnykh O, Franzblau SG, Mesecar AD. Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Biochemistry. 52: 912-25. PMID 23298222 DOI: 10.1021/Bi300928U  1
2012 Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS. Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation. Bioorganic & Medicinal Chemistry Letters. 22: 7578-81. PMID 23131339 DOI: 10.1016/J.Bmcl.2012.10.005  1
2012 Reddy PV, Jensen KC, Mesecar AD, Fanwick PE, Cushman M. Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2. Journal of Medicinal Chemistry. 55: 367-77. PMID 22206487 DOI: 10.1021/Jm201251C  1
2012 Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry. 421: 108-14. PMID 22074792 DOI: 10.1016/J.Ab.2011.10.028  1
2011 Park SK, Pegan SD, Mesecar AD, Jungbauer LM, LaDu MJ, Liebman SW. Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization. Disease Models & Mechanisms. 4: 822-31. PMID 21810907 DOI: 10.1242/Dmm.007963  1
2011 Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice. Chemmedchem. 6: 1593-602. PMID 21732538 DOI: 10.1002/Cmdc.201100188  1
2011 Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Molecular Nutrition & Food Research. 55: 1249-65. PMID 21714126 DOI: 10.1002/Mnfr.201100122  1
2011 Wubben T, Mesecar AD. Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 541-5. PMID 21543857 DOI: 10.1107/S1744309111010761  1
2011 Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Science : a Publication of the Protein Society. 20: 1182-95. PMID 21538647 DOI: 10.1002/Pro.647  1
2011 Hu C, Eggler AL, Mesecar AD, van Breemen RB. Modification of keap1 cysteine residues by sulforaphane. Chemical Research in Toxicology. 24: 515-21. PMID 21391649 DOI: 10.1021/Tx100389R  1
2011 Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, et al. Bioactive compounds from the fern Lepisorus contortus. Journal of Natural Products. 74: 129-36. PMID 21261296 DOI: 10.1021/Np100373F  1
2011 Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB, et al. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Analytical Chemistry. 83: 1048-52. PMID 21192729 DOI: 10.1021/Ac1028424  1
2010 Conda-Sheridan M, Marler L, Park EJ, Kondratyuk TP, Jermihov K, Mesecar AD, Pezzuto JM, Asolkar RN, Fenical W, Cushman M. Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. Journal of Medicinal Chemistry. 53: 8688-99. PMID 21105712 DOI: 10.1021/Jm1011066  1
2010 Wubben TJ, Mesecar AD. Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis. Journal of Molecular Biology. 404: 202-19. PMID 20851704 DOI: 10.1016/j.jmb.2010.09.002  1
2010 Small E, Eggler A, Mesecar AD. Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. Biochemical and Biophysical Research Communications. 400: 471-5. PMID 20735986 DOI: 10.1016/J.Bbrc.2010.08.062  1
2010 Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto JM, Mesecar AD, Cushman M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorganic & Medicinal Chemistry. 18: 5352-66. PMID 20558073 DOI: 10.1016/J.Bmc.2010.05.042  1
2010 Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. Journal of Medicinal Chemistry. 53: 4968-79. PMID 20527968 DOI: 10.1021/Jm1004489  1
2010 Burks EA, Fleming CD, Mesecar AD, Whitman CP, Pegan SD. Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily . Biochemistry. 49: 5016-27. PMID 20465238 DOI: 10.1021/Bi100502Z  1
2010 Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. The Biochemical Journal. 429: 273-82. PMID 20450491 DOI: 10.1042/Bj20091857  1
2010 Pegan SD, Tian Y, Sershon V, Mesecar AD. A universal, fully automated high throughput screening assay for pyrophosphate and phosphate release from enzymatic reactions. Combinatorial Chemistry & High Throughput Screening. 13: 27-38. PMID 20201823 DOI: 10.2174/138620710790218203  1
2010 Clementz MA, Chen Z, Banach BS, Wang Y, Sun L, Ratia K, Baez-Santos YM, Wang J, Takayama J, Ghosh AK, Li K, Mesecar AD, Baker SC. Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. Journal of Virology. 84: 4619-29. PMID 20181693 DOI: 10.1128/Jvi.02406-09  1
2010 Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, Van Breemen RB, Pezzuto JM, Fong HH, et al. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 71: 641-7. PMID 20100622 DOI: 10.1016/J.Phytochem.2010.01.002  1
2010 Marler LE, Cushman M, Sun B, Mesecar AD, Jermihov K, Breemen RBv, Pezzuto JM. Abstract A68: Aromatase inhibition and chemopreventive potential of novel resveratrol derivatives Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A68  1
2010 Eggler AL, Small E, Hannink M, Mesecar AD. Abstract A58: Cul3‐mediated Nrf2 ubiquitination and ARE activation are dependent on the partial molar volume at position 151 of Keap1 Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A58  1
2009 Zhang H, Rothwangl K, Mesecar AD, Sabahi A, Rong L, Fong HH. Lamiridosins, hepatitis C virus entry inhibitors from Lamium album. Journal of Natural Products. 72: 2158-62. PMID 19904996 DOI: 10.1021/Np900549E  1
2009 Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/J.Bmc.2009.08.061  1
2009 Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. Journal of Medicinal Chemistry. 52: 5228-40. PMID 19645480 DOI: 10.1021/Jm900611T  1
2009 Hawwa R, Larsen SD, Ratia K, Mesecar AD. Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans. Journal of Molecular Biology. 393: 36-57. PMID 19631223 DOI: 10.1016/J.Jmb.2009.06.083  1
2009 Hawwa R, Aikens J, Turner RJ, Santarsiero BD, Mesecar AD. Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus. Archives of Biochemistry and Biophysics. 488: 109-20. PMID 19615330 DOI: 10.1016/J.Abb.2009.06.005  1
2009 Eggler AL, Small E, Hannink M, Mesecar AD. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. The Biochemical Journal. 422: 171-80. PMID 19489739 DOI: 10.1042/Bj20090471  1
2009 Kim KH, Gaisina I, Gallier F, Holzle D, Blond SY, Mesecar A, Kozikowski AP. Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl) maleimides as GSK-3β inhibitors Journal of Molecular Modeling. 15: 1463-1479. PMID 19440740 DOI: 10.1007/S00894-009-0498-X  1
2009 Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS. Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. Journal of Virology. 83: 6689-705. PMID 19369340 DOI: 10.1128/Jvi.02220-08  1
2009 Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of Medicinal Chemistry. 52: 1873-84. PMID 19265439 DOI: 10.1021/Jm801335Z  1
2009 Pegan SD, Rukseree K, Franzblau SG, Mesecar AD. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Journal of Molecular Biology. 386: 1038-53. PMID 19167403 DOI: 10.1016/J.Jmb.2009.01.003  1
2009 Sershon VC, Santarsiero BD, Mesecar AD. Kinetic and X-ray structural evidence for negative cooperativity in substrate binding to nicotinate mononucleotide adenylyltransferase (NMAT) from Bacillus anthracis. Journal of Molecular Biology. 385: 867-88. PMID 18977360 DOI: 10.1016/J.Jmb.2008.10.037  1
2008 Pegan SD, Serrano H, Whitman CP, Mesecar AD. Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallographica. Section D, Biological Crystallography. 64: 1277-82. PMID 19018104 DOI: 10.1107/S0907444908034707  1
2008 Tian Y, Suk DH, Cai F, Crich D, Mesecar AD. Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediate. Biochemistry. 47: 12434-47. PMID 18973344 DOI: 10.1021/Bi801311D  1
2008 Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proceedings of the National Academy of Sciences of the United States of America. 105: 16119-24. PMID 18852458 DOI: 10.1073/Pnas.0805240105  1
2008 McAdams K, Casper ES, Matthew Haas R, Santarsiero BD, Eggler AL, Mesecar A, Halkides CJ. The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Archives of Biochemistry and Biophysics. 479: 105-13. PMID 18801331 DOI: 10.1016/J.Abb.2008.08.019  1
2008 Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5684-8. PMID 18796354 DOI: 10.1016/J.Bmcl.2008.08.082  1
2008 Holland R, Hawkins AE, Eggler AL, Mesecar AD, Fabris D, Fishbein JC. Prospective type 1 and type 2 disulfides of Keap1 protein. Chemical Research in Toxicology. 21: 2051-60. PMID 18729328 DOI: 10.1021/Tx800226M  1
2008 Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem. 3: 1250-68. PMID 18663709 DOI: 10.1002/Cmdc.200800047  1
2008 Mesecar AD, Ratia K. Viral destruction of cell surface receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 8807-8. PMID 18574141 DOI: 10.1073/Pnas.0804355105  1
2008 Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/J.Bmcl.2008.05.004  1
2008 Eggler AL, Gay KA, Mesecar AD. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Molecular Nutrition & Food Research. 52: S84-94. PMID 18435489 DOI: 10.1002/Mnfr.200700249  1
2008 Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. The Biochemical Journal. 413: 81-91. PMID 18254726 DOI: 10.1042/Bj20071373  1
2008 Grum-Tokars V, Ratia K, Begaye A, Baker SC, Mesecar AD. Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. Virus Research. 133: 63-73. PMID 17397958 DOI: 10.1016/J.Virusres.2007.02.015  1
2008 Eggler AL, Luo Y, Van Breemen RB, Mesecar AD. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent (Chemical Research in Toxicology (2007) 20, 12, (1878-1884)) Chemical Research in Toxicology. 21: 556. DOI: 10.1021/Tx800015C  1
2007 Ghosh AK, Xi K, Johnson ME, Baker SC, Mesecar AD. Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annual Reports in Medicinal Chemistry. 41: 183-196. PMID 19649165 DOI: 10.1016/S0065-7743(06)41011-3  1
2007 Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society For Mass Spectrometry. 18: 2226-32. PMID 17980616 DOI: 10.1016/J.Jasms.2007.09.015  1
2007 Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chemical Research in Toxicology. 20: 1878-84. PMID 17935299 DOI: 10.1021/Tx700217C  1
2007 Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5876-80. PMID 17855091 DOI: 10.1016/J.Bmcl.2007.08.031  1
2007 May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD. Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. Journal of Molecular Biology. 371: 1219-37. PMID 17610893 DOI: 10.1016/J.Jmb.2007.05.093  1
2007 Chen Z, Wang Y, Ratia K, Mesecar AD, Wilkinson KD, Baker SC. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. Journal of Virology. 81: 6007-18. PMID 17392370 DOI: 10.1128/Jvi.02747-06  1
2006 Cuendet M, Mesecar AD, DeWitt DL, Pezzuto JM. An ELISA method to measure inhibition of the COX enzymes. Nature Protocols. 1: 1915-21. PMID 17487176 DOI: 10.1038/Nprot.2006.308  1
2006 Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochemical Analysis : Pca. 17: 398-405. PMID 17144247 DOI: 10.1002/Pca.937  1
2006 Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Deubiquitinating activity of the SARS-CoV papain-like protease. Advances in Experimental Medicine and Biology. 581: 37-41. PMID 17037501 DOI: 10.1007/978-0-387-33012-9_5  1
2006 Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proceedings of the National Academy of Sciences of the United States of America. 103: 5717-22. PMID 16581910 DOI: 10.1073/Pnas.0510851103  1
2006 Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Santarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH. Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Medica. 72: 255-60. PMID 16534731 DOI: 10.1055/S-2005-873171  1
2006 Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH. Miliusanes, a class of cytotoxic agents from Miliusa sinensis. Journal of Medicinal Chemistry. 49: 693-708. PMID 16420055 DOI: 10.1021/Jm0509492  1
2006 Su BN, Chai H, Mi Q, Riswan S, Kardono LB, Afriastini JJ, Santarsiero BD, Mesecar AD, Farnsworth NR, Cordell GA, Swanson SM, Kinghorn AD. Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia. Bioorganic & Medicinal Chemistry. 14: 960-72. PMID 16216518 DOI: 10.1016/J.Bmc.2005.09.012  1
2006 Mason TE, Abernathy D, Anderson I, Ankner J, Egami T, Ehlers G, Ekkebus A, Granroth G, Hagen M, Herwig K, Hodges J, Hoffmann C, Horak C, Horton L, Klose F, ... ... Mesecar A, et al. The Spallation Neutron Source in Oak Ridge: A powerful tool for materials research Physica B: Condensed Matter. 385: 955-960. DOI: 10.1016/J.Physb.2006.05.281  1
2005 Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. Journal of Virology. 79: 15189-98. PMID 16306590 DOI: 10.1128/Jvi.79.24.15189-15198.2005  1
2005 Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. Journal of Medicinal Chemistry. 48: 6767-71. PMID 16250632 DOI: 10.1021/Jm050548M  1
2005 Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Analytical Chemistry. 77: 6407-14. PMID 16194107 DOI: 10.1021/Ac050892R  1
2005 Grimsley JK, Calamini B, Wild JR, Mesecar AD. Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site. Archives of Biochemistry and Biophysics. 442: 169-79. PMID 16188223 DOI: 10.1016/J.Abb.2005.08.012  1
2005 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chemical Research in Toxicology. 18: 1296-305. PMID 16097803 DOI: 10.1021/Tx050058X  1
2005 Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences of the United States of America. 102: 10070-5. PMID 16006525 DOI: 10.1073/Pnas.0502402102  1
2005 Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry. 44: 9417-29. PMID 15996096 DOI: 10.1107/S010876730509210X  1
2005 Thiyagarajan P, Schultz AJ, Rehm C, Hodges JP, Myles DA, Langan PA, Mesecar AD. Design of a high resolution macromolecular neutron diffractometer (MaNDi) for structural biology research at the SNS Acta Crystallographica Section A. 61: 144-144. DOI: 10.1107/S0108767305093876  1
2005 Schultz AJ, Thiyagarajan P, Hodges JP, Rehm C, Myles DAA, Langan P, Mesecar AD. Conceptual design of a macromolecular neutron diffractometer (MaNDi) for the SNS Journal of Applied Crystallography. 38: 964-974. DOI: 10.1107/S0021889805030256  1
2004 Rumthao S, Lee O, Sheng Q, Fu W, Mulhearn DC, Crich D, Mesecar AD, Johnson ME. Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa. Bioorganic & Medicinal Chemistry Letters. 14: 5165-70. PMID 15380220 DOI: 10.1016/J.Bmcl.2004.07.054  1
2004 Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. Journal of Natural Products. 67: 994-8. PMID 15217281 DOI: 10.1021/Np030469I  1
2004 Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, et al. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. The Journal of Organic Chemistry. 69: 3350-8. PMID 15132542 DOI: 10.1021/Jo040120F  1
2004 Li Y, Yao J, Chang M, Nikolic D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chemical Research in Toxicology. 17: 512-20. PMID 15089093 DOI: 10.1021/Tx0342464  1
2004 Graham JG, Zhang H, Pendland SL, Santarsiero BD, Mesecar AD, Cabieses F, Farnsworth NR. Antimycobacterial Naphthopyrones from Senna obliqua. Journal of Natural Products. 67: 225-7. PMID 14987063 DOI: 10.1021/Np030348I  1
2003 Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. Journal of Agricultural and Food Chemistry. 51: 5661-70. PMID 12952416 DOI: 10.1021/Jf034264R  1
2003 Su BN, Kang YH, Pinos RE, Santarsiero BD, Mesecar AD, Soejarto DD, Fong HH, Pezzuto JM, Kinghorn AD. Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis. Phytochemistry. 64: 293-302. PMID 12946428 DOI: 10.1016/S0031-9422(03)00268-1  1
2003 Rao KV, Santarsiero BD, Mesecar AD, Schinazi RF, Tekwani BL, Hamann MT. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. Journal of Natural Products. 66: 823-8. PMID 12828469 DOI: 10.1021/Np020592U  1
2003 Zhang HJ, Tan GT, Santarsiero BD, Mesecar AD, Hung NV, Cuong NM, Doel Soejarto D, Pezzuto JM, Fong HH. New Sesquiterpenes from Litsea verticillata. Journal of Natural Products. 66: 609-15. PMID 12762792 DOI: 10.1021/Np020508A  1
2003 Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). Journal of Natural Products. 66: 583-7. PMID 12762787 DOI: 10.1021/Np020522N  1
2003 Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, Van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chemical Research in Toxicology. 16: 668-75. PMID 12755597 DOI: 10.1021/Tx0340549  1
2003 Su BN, Park EJ, Nikolic D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity. The Journal of Organic Chemistry. 68: 2350-61. PMID 12636402 DOI: 10.1021/Jo020542U  1
2003 Park S, Hayes BL, Marankan F, Mulhearn DC, Wanna L, Mesecar AD, Santarsiero BD, Johnson ME, Venton DL. Regioselective covalent modification of hemoglobin in search of antisickling agents. Journal of Medicinal Chemistry. 46: 936-53. PMID 12620071 DOI: 10.1021/Jm020361K  1
2002 Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase. Journal of Agricultural and Food Chemistry. 50: 6330-4. PMID 12381112 DOI: 10.1021/Jf0206670  1
2002 Su BN, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Fong HH, Pezzuto JM, Kinghorn AD. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. Journal of Natural Products. 65: 1278-82. PMID 12350147 DOI: 10.1021/Np0202475  1
2002 Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG. Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms DIRECT AND INDIRECT EFFECTS ON NUCLEAR/CYTOPLASMIC SHUTTLING AND DNA BINDING Journal of Biological Chemistry. 277: 45276-45284. PMID 12228231 DOI: 10.1074/Jbc.M208063200  1
2002 Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. Bioactive constituents of the seeds of Brucea javanica. Planta Medica. 68: 730-3. PMID 12221597 DOI: 10.1055/S-2002-33798  1
2002 Chen SN, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. Journal of Natural Products. 65: 601-5. PMID 11975513 DOI: 10.1021/Np010494T  1
2002 Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME. An oxyanion-Hole selective serine protease inhibitor in complex with trypsin Bioorganic and Medicinal Chemistry. 10: 41-46. PMID 11738605 DOI: 10.1016/S0968-0896(01)00259-0  1
2002 Li SH, Zhang HJ, Qiu SX, Niu XM, Santarsiero BD, Mesecar AD, Fong HHS, Farnsworth NR, Sun HD. Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus Tetrahedron Letters. 43: 5131-5134. DOI: 10.1016/S0040-4039(02)00981-4  1
2002 Su BN, Misico R, Jung Park E, Santarsiero BD, Mesecar AD, Fong HHS, Pezzuto JM, Douglas Kinghorn A. Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica Tetrahedron. 58: 3453-3466. DOI: 10.1016/S0040-4020(02)00277-6  1
2001 Velichutina IV, Hong JY, Mesecar AD, Chernoff YO, Liebman SW. Genetic interaction between yeast Saccharomyces cerevisiae release factors and the decoding region of 18 S rRNA. Journal of Molecular Biology. 305: 715-27. PMID 11162087 DOI: 10.1006/Jmbi.2000.4329  1
2000 Mesecar AD, Koshland DE. Sites of binding and orientation in a four-location model for protein stereospecificity. Iubmb Life. 49: 457-66. PMID 10902579 DOI: 10.1080/152165400410326  1
2000 Freiberg G, Mesecar AD, Huang H, Hong JY, Liebman SW. Characterization of novel rad6/ubc2 ubiquitin-conjugating enzyme mutants in yeast. Current Genetics. 37: 221-33. PMID 10803884 DOI: 10.1007/S002940050523  1
2000 Mesecar AD, Koshland DE. A new model for protein stereospecificity. Nature. 403: 614-5. PMID 10688187 DOI: 10.1038/35001144  1
1999 Bollenbach TJ, Mesecar AD, Nowak T. Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis. Biochemistry. 38: 9137-45. PMID 10413488 DOI: 10.1021/Bi990690N  1
1998 Stoddard BL, Cohen BE, Brubaker M, Mesecar AD, Koshland DE. Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs. Nature Structural Biology. 5: 891-7. PMID 9783749 DOI: 10.1038/2331  1
1998 Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate Structure. 6: 195-210. PMID 9519410 DOI: 10.1016/S0969-2126(98)00021-5  1
1997 Mesecar AD, Stoddard BL, Koshland DE. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science (New York, N.Y.). 277: 202-6. PMID 9211842 DOI: 10.1126/Science.277.5323.202  1
1997 Mesecar AD, Nowak T. Metal-ion-mediated allosteric triggering of yeast pyruvate kinase 2. A multidimensional thermodynamic linked-function analysis Biochemistry. 36: 6803-6813. PMID 9184163 DOI: 10.1021/bi962870s  1
1997 Mesecar AD, Nowak T. Metal-ion-mediated allosteric triggering of yeast pyruvate kinase. 1. A multidimensional kinetic linked-function analysis Biochemistry. 36: 6792-6802. PMID 9184162 DOI: 10.1021/Bi962869T  1
1997 Mesecar AD, Stoddard BL, Koshtand DE. Small conformational changes of an enzyme under catalytic turnover-the isocitrate dehydrogenase catalyzed reaction Faseb Journal. 11: A1314.  1
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