Paul Schimmel, Ph.D. - Publications

Affiliations: 
The Skaggs Institute Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Biophysical Chemistry & Translational Medicine
Website:
http://www.scripps.edu/schimmel/

205 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Blocquel D, Sun L, Matuszek Z, Li S, Weber T, Kuhle B, Kooi G, Wei N, Baets J, Pan T, Schimmel P, Yang XL. CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31501329 DOI: 10.1073/pnas.1908288116  0.48
2018 Naganuma M, Sekine SI, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S. Author Correction: The selective tRNA aminoacylation mechanism based on a single G•U pair. Nature. PMID 30459470 DOI: 10.1038/s41586-018-0760-4  0.48
2018 Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. Proceedings of the National Academy of Sciences of the United States of America. PMID 30104364 DOI: 10.1073/pnas.1807000115  0.48
2018 Xu Z, Lo WS, Beck DB, Schuch LA, Oláhová M, Kopajtich R, Chong YE, Alston CL, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc CA, Borczuk AC, Teich AF, ... ... Schimmel P, et al. Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function. American Journal of Human Genetics. 103: 100-114. PMID 29979980 DOI: 10.1016/j.ajhg.2018.06.006  0.48
2018 Chong YE, Guo M, Yang XL, Kuhle B, Naganuma M, Sekine SI, Yokoyama S, Schimmel P. Distinct ways of G:U recognition by conserved tRNA binding motifs. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967150 DOI: 10.1073/pnas.1807109115  0.48
2018 Vo MN, Terrey M, Lee JW, Roy B, Moresco JJ, Sun L, Fu H, Liu Q, Weber TG, Yates JR, Fredrick K, Schimmel P, Ackerman SL. Publisher Correction: ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Nature. PMID 29925958 DOI: 10.1038/s41586-018-0271-3  0.52
2018 Vo MN, Terrey M, Lee JW, Roy B, Moresco JJ, Sun L, Fu H, Liu Q, Weber TG, Yates JR, Fredrick K, Schimmel P, Ackerman SL. ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Nature. PMID 29769718 DOI: 10.1038/s41586-018-0137-8  0.52
2018 Song Y, Zhou H, Vo MN, Shi Y, Nawaz MH, Vargas-Rodriguez O, Diedrich JK, Yates JR, Kishi S, Musier-Forsyth K, Schimmel P. Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nature Communications. 9: 1113. PMID 29535387 DOI: 10.1038/s41467-018-03594-1  0.52
2017 Song Y, Zhou H, Vo MN, Shi Y, Nawaz MH, Vargas-Rodriguez O, Diedrich JK, Yates JR, Kishi S, Musier-Forsyth K, Schimmel P. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nature Communications. 8: 2281. PMID 29273753 DOI: 10.1038/s41467-017-02201-z  0.52
2017 Xu X, Zhou H, Zhou Q, Hong F, Vo MN, Niu W, Wang Z, Xiong X, Nakamura K, Wakasugi K, Schimmel P, Yang XL. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. Rna Biology. 0. PMID 28910573 DOI: 10.1080/15476286.2017.1377868  0.52
2017 Blocquel D, Li S, Wei N, Daub H, Sajish M, Erfurth ML, Kooi G, Zhou J, Bai G, Schimmel P, Jordanova A, Yang XL. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Nucleic Acids Research. PMID 28531329 DOI: 10.1093/nar/gkx455  0.48
2016 Sun L, Song Y, Blocquel D, Yang XL, Schimmel P. Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911835 DOI: 10.1073/pnas.1617316113  0.48
2016 Sun L, Gomes AC, He W, Zhou H, Wang X, Pan DW, Schimmel P, Pan T, Yang XL. Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair. Journal of the American Chemical Society. PMID 27622773 DOI: 10.1021/jacs.6b07121  0.48
2016 Song Y, Shi Y, Carland TM, Lian S, Sasaki T, Schork NJ, Head SR, Kishi S, Schimmel P. p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402763 DOI: 10.1073/pnas.1608139113  0.52
2016 Wei Z, Xu Z, Liu X, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang M, Schimmel P. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Research. PMID 26773056 DOI: 10.1093/nar/gkw002  1
2015 Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, ... Schimmel P, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science Translational Medicine. 7: 288ra77. PMID 25995223 DOI: 10.1126/scitranslmed.aaa3575  0.48
2014 Liu Y, Satz JS, Vo MN, Nangle LA, Schimmel P, Ackerman SL. Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Proceedings of the National Academy of Sciences of the United States of America. 111: 17570-5. PMID 25422440 DOI: 10.1073/pnas.1420196111  1
2014 Ishimura R, Nagy G, Dotu I, Zhou H, Yang XL, Schimmel P, Senju S, Nishimura Y, Chuang JH, Ackerman SL. RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science (New York, N.Y.). 345: 455-9. PMID 25061210 DOI: 10.1126/science.1249749  1
2014 Lo WS, Gardiner E, Xu Z, Lau CF, Wang F, Zhou JJ, Mendlein JD, Nangle LA, Chiang KP, Yang XL, Au KF, Wong WH, Guo M, Zhang M, Schimmel P. Human tRNA synthetase catalytic nulls with diverse functions. Science (New York, N.Y.). 345: 328-32. PMID 25035493 DOI: 10.1126/science.1252943  1
2014 Naganuma M, Sekine S, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S. The selective tRNA aminoacylation mechanism based on a single G•U pair. Nature. 510: 507-11. PMID 24919148 DOI: 10.1038/nature13440  1
2014 Zhou JJ, Wang F, Xu Z, Lo WS, Lau CF, Chiang KP, Nangle LA, Ashlock MA, Mendlein JD, Yang XL, Zhang M, Schimmel P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis. The Journal of Biological Chemistry. 289: 19269-75. PMID 24898250 DOI: 10.1074/jbc.C114.571026  1
2013 Wang F, Xu Z, Zhou J, Lo WS, Lau CF, Nangle LA, Yang XL, Zhang M, Schimmel P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases. The Journal of Biological Chemistry. 288: 29223-8. PMID 24003230 DOI: 10.1074/jbc.C113.490599  1
2013 Guo M, Schimmel P. Essential nontranslational functions of tRNA synthetases. Nature Chemical Biology. 9: 145-53. PMID 23416400 DOI: 10.1038/nchembio.1158  1
2013 Klipcan L, Safro M, Schimmel P. Anticodon G recognition by tRNA synthetases mimics the tRNA core. Trends in Biochemical Sciences. 38: 229-32. PMID 23266103 DOI: 10.1016/j.tibs.2012.11.002  1
2013 Zhou H, Sun L, Yang XL, Schimmel P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 494: 121-4. PMID 23263184 DOI: 10.1038/nature11774  1
2013 Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Pozo J, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, et al. Structural switch of lysyl-tRNA synthetase between translation and transcription. Molecular Cell. 49: 30-42. PMID 23159739 DOI: 10.1016/j.molcel.2012.10.010  1
2012 Xu Z, Wei Z, Zhou JJ, Ye F, Lo WS, Wang F, Lau CF, Wu J, Nangle LA, Chiang KP, Yang XL, Zhang M, Schimmel P. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Structure (London, England : 1993). 20: 1470-7. PMID 22958643 DOI: 10.1016/j.str.2012.08.001  1
2012 Guo M, Schimmel P. Homeostatic mechanisms by alternative forms of tRNA synthetases. Trends in Biochemical Sciences. 37: 401-3. PMID 22858252 DOI: 10.1016/j.tibs.2012.07.003  1
2012 Lee PS, Zhang HM, Marshall AG, Yang XL, Schimmel P. Uncovering of a short internal peptide activates a tRNA synthetase procytokine. The Journal of Biological Chemistry. 287: 20504-8. PMID 22549774 DOI: 10.1074/jbc.C112.369439  1
2012 Sajish M, Zhou Q, Kishi S, Valdez DM, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nature Chemical Biology. 8: 547-54. PMID 22504299 DOI: 10.1038/nchembio.937  1
2012 Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, Cho K, Park YW, Guo M, He W, Yang XL, Schimmel P, Kim S. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 109: E640-7. PMID 22345558 DOI: 10.1073/pnas.1200194109  1
2012 Wang J, Fang P, Schimmel P, Guo M. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor. The Journal of Physical Chemistry. B. 116: 6798-805. PMID 22329685 DOI: 10.1021/jp212457w  1
2012 Guo M, Schimmel P. Structural analyses clarify the complex control of mistranslation by tRNA synthetases. Current Opinion in Structural Biology. 22: 119-26. PMID 22155179 DOI: 10.1016/j.sbi.2011.11.008  1
2011 Schimmel P. Mistranslation and its control by tRNA synthetases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 2965-71. PMID 21930589 DOI: 10.1098/rstb.2011.0158  1
2011 Yang XL, Schimmel P. Functional expansion of the tRNA world under stress. Molecular Cell. 43: 500-2. PMID 21855789 DOI: 10.1016/j.molcel.2011.08.004  1
2011 Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 8239-44. PMID 21536907 DOI: 10.1073/pnas.1100224108  1
2011 Vo MN, Yang XL, Schimmel P. Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase. The Journal of Biological Chemistry. 286: 11563-8. PMID 21310955 DOI: 10.1074/jbc.C110.213876  1
2011 Schimmel P. The RNP bridge between two worlds. Nature Reviews. Molecular Cell Biology. 12: 135. PMID 21285979 DOI: 10.1038/nrm3061  1
2011 Nawaz MH, Merriman E, Yang XL, Schimmel P. p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 108: 2723-8. PMID 21285375 DOI: 10.1073/pnas.1019400108  1
2010 Guo M, Shapiro R, Morris GM, Yang XL, Schimmel P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase. The Journal of Physical Chemistry. B. 114: 16273-9. PMID 21058683 DOI: 10.1021/jp1082517  1
2010 Han GW, Yang XL, McMullan D, Chong YE, Krishna SS, Rife CL, Weekes D, Brittain SM, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Caruthers J, Chiu HJ, ... ... Schimmel P, et al. Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1326-34. PMID 20944229 DOI: 10.1107/S1744309110037619  1
2010 Guo M, Yang XL, Schimmel P. New functions of aminoacyl-tRNA synthetases beyond translation. Nature Reviews. Molecular Cell Biology. 11: 668-74. PMID 20700144 DOI: 10.1038/nrm2956  1
2010 Guo M, Shapiro R, Schimmel P, Yang XL. Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase. Acta Crystallographica. Section D, Biological Crystallography. 66: 243-50. PMID 20179335 DOI: 10.1107/S0907444909055462  1
2010 Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nature Structural & Molecular Biology. 17: 57-61. PMID 20010843 DOI: 10.1038/nsmb.1706  1
2010 Guo M, Schimmel P, Yang XL. Functional expansion of human tRNA synthetases achieved by structural inventions. Febs Letters. 584: 434-42. PMID 19932696 DOI: 10.1016/j.febslet.2009.11.064  1
2009 Guo M, Chong YE, Shapiro R, Beebe K, Yang XL, Schimmel P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature. 462: 808-12. PMID 20010690 DOI: 10.1038/nature08612  1
2009 Sankaran B, Bonnett SA, Shah K, Gabriel S, Reddy R, Schimmel P, Rodionov DA, de Crécy-Lagard V, Helmann JD, Iwata-Reuyl D, Swairjo MA. Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB. Journal of Bacteriology. 191: 6936-49. PMID 19767425 DOI: 10.1128/JB.00287-09  1
2009 Guo M, Chong YE, Beebe K, Shapiro R, Yang XL, Schimmel P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA. Science (New York, N.Y.). 325: 744-7. PMID 19661429 DOI: 10.1126/science.1174343  1
2009 Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang XL, Schimmel P, Norga K, Timmerman V, Callaerts P, Jordanova A. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proceedings of the National Academy of Sciences of the United States of America. 106: 11782-7. PMID 19561293 DOI: 10.1073/pnas.0905339106  1
2009 Schimmel P, Guo M. A tipping point for mistranslation and disease. Nature Structural & Molecular Biology. 16: 348-9. PMID 19343067 DOI: 10.1038/nsmb0409-348  1
2009 El Yacoubi B, Lyons B, Cruz Y, Reddy R, Nordin B, Agnelli F, Williamson JR, Schimmel P, Swairjo MA, de Crécy-Lagard V. The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. Nucleic Acids Research. 37: 2894-909. PMID 19287007 DOI: 10.1093/nar/gkp152  1
2009 Schimmel P, Guo M. Ancient tRNA synthetase meets modern structural biology. Structure (London, England : 1993). 17: 315-7. PMID 19278642 DOI: 10.1016/j.str.2009.02.002  1
2008 Schimmel P. Development of tRNA synthetases and connection to genetic code and disease. Protein Science : a Publication of the Protein Society. 17: 1643-52. PMID 18765819 DOI: 10.1110/ps.037242.108  1
2008 Cheng G, Zhang H, Yang X, Tzima E, Ewalt KL, Schimmel P, Faber JE. Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1138-46. PMID 18753262 DOI: 10.1152/ajpregu.90519.2008  1
2008 Chong YE, Yang XL, Schimmel P. Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation. The Journal of Biological Chemistry. 283: 30073-8. PMID 18723508 DOI: 10.1074/jbc.M805943200  1
2008 Park SG, Schimmel P, Kim S. Aminoacyl tRNA synthetases and their connections to disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 11043-9. PMID 18682559 DOI: 10.1073/pnas.0802862105  1
2008 Schimmel P. An editing activity that prevents mistranslation and connection to disease. The Journal of Biological Chemistry. 283: 28777-82. PMID 18640977 DOI: 10.1074/jbc.X800007200  1
2008 Guo M, Ignatov M, Musier-Forsyth K, Schimmel P, Yang XL. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation. Proceedings of the National Academy of Sciences of the United States of America. 105: 2331-6. PMID 18272479 DOI: 10.1073/pnas.0712072105  1
2008 Zhou Q, Kiosses WB, Liu J, Schimmel P. Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine. Methods (San Diego, Calif.). 44: 190-5. PMID 18241800 DOI: 10.1016/j.ymeth.2007.10.004  1
2008 Beebe K, Mock M, Merriman E, Schimmel P. Distinct domains of tRNA synthetase recognize the same base pair. Nature. 451: 90-3. PMID 18172502 DOI: 10.1038/nature06454  1
2008 Greenberg Y, King M, Kiosses WB, Ewalt K, Yang X, Schimmel P, Reader JS, Tzima E. The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1597-605. PMID 18165356 DOI: 10.1096/fj.07-9973com  1
2008 Kapoor M, Zhou Q, Otero F, Myers CA, Bates A, Belani R, Liu J, Luo JK, Tzima E, Zhang DE, Yang XL, Schimmel P. Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS. The Journal of Biological Chemistry. 283: 2070-7. PMID 17999956 DOI: 10.1074/jbc.M706028200  1
2007 Yang XL, Kapoor M, Otero FJ, Slike BM, Tsuruta H, Frausto R, Bates A, Ewalt KL, Cheresh DA, Schimmel P. Gain-of-function mutational activation of human tRNA synthetase procytokine. Chemistry & Biology. 14: 1323-33. PMID 18096501 DOI: 10.1016/j.chembiol.2007.10.016  1
2007 Waas WF, Schimmel P. Evidence that tRNA synthetase-directed proton transfer stops mistranslation. Biochemistry. 46: 12062-70. PMID 17924654 DOI: 10.1021/bi7007454  1
2007 Zubieta C, Joseph R, Krishna SS, McMullan D, Kapoor M, Axelrod HL, Miller MD, Abdubek P, Acosta C, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, ... ... Schimmel P, et al. Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA. Proteins. 69: 234-43. PMID 17654547 DOI: 10.1002/prot.21673  1
2007 Zubieta C, Krishna SS, Kapoor M, Kozbial P, McMullan D, Axelrod HL, Miller MD, Abdubek P, Ambing E, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, ... ... Schimmel P, et al. Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif. Proteins. 69: 223-33. PMID 17654545 DOI: 10.1002/prot.21550  1
2007 Yang XL, Guo M, Kapoor M, Ewalt KL, Otero FJ, Skene RJ, McRee DE, Schimmel P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase. Structure (London, England : 1993). 15: 793-805. PMID 17637340 DOI: 10.1016/j.str.2007.05.009  1
2007 Waas WF, Druzina Z, Hanan M, Schimmel P. Role of a tRNA base modification and its precursors in frameshifting in eukaryotes. The Journal of Biological Chemistry. 282: 26026-34. PMID 17623669 DOI: 10.1074/jbc.M703391200  1
2007 Bacher JM, Waas WF, Metzgar D, de Crécy-Lagard V, Schimmel P. Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi. Journal of Bacteriology. 189: 6494-6. PMID 17616603 DOI: 10.1128/JB.00622-07  1
2007 Beebe K, Waas W, Druzina Z, Guo M, Schimmel P. A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities. Analytical Biochemistry. 368: 111-21. PMID 17603003 DOI: 10.1016/j.ab.2007.05.013  1
2007 Nangle LA, Zhang W, Xie W, Yang XL, Schimmel P. Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect. Proceedings of the National Academy of Sciences of the United States of America. 104: 11239-44. PMID 17595294 DOI: 10.1073/pnas.0705055104  1
2007 Xie W, Nangle LA, Zhang W, Schimmel P, Yang XL. Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 104: 9976-81. PMID 17545306 DOI: 10.1073/pnas.0703908104  1
2007 Bacher JM, Schimmel P. An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Proceedings of the National Academy of Sciences of the United States of America. 104: 1907-12. PMID 17264207 DOI: 10.1073/pnas.0610835104  1
2006 Schimmel P, Yang XL. Perfecting the genetic code with an RNP complex. Structure (London, England : 1993). 14: 1729-30. PMID 17161363 DOI: 10.1016/j.str.2006.11.002  1
2006 Xie W, Schimmel P, Yang XL. Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1243-6. PMID 17142907 DOI: 10.1107/S1744309106046434  1
2006 Nangle LA, Motta CM, Schimmel P. Global effects of mistranslation from an editing defect in mammalian cells. Chemistry & Biology. 13: 1091-100. PMID 17052613 DOI: 10.1016/j.chembiol.2006.08.011  1
2006 Seburn KL, Nangle LA, Cox GA, Schimmel P, Burgess RW. An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model. Neuron. 51: 715-26. PMID 16982418 DOI: 10.1016/j.neuron.2006.08.027  1
2006 Tamura K, Schimmel PR. Chiral-selective aminoacylation of an RNA minihelix: Mechanistic features and chiral suppression. Proceedings of the National Academy of Sciences of the United States of America. 103: 13750-2. PMID 16950872 DOI: 10.1073/pnas.0606070103  1
2006 Lee JW, Beebe K, Nangle LA, Jang J, Longo-Guess CM, Cook SA, Davisson MT, Sundberg JP, Schimmel P, Ackerman SL. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 443: 50-5. PMID 16906134 DOI: 10.1038/nature05096  1
2006 Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Köhrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P. Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. The Embo Journal. 25: 2919-29. PMID 16724112 DOI: 10.1038/sj.emboj.7601154  1
2006 Tzima E, Schimmel P. Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. Trends in Biochemical Sciences. 31: 7-10. PMID 16297628 DOI: 10.1016/j.tibs.2005.11.002  1
2006 Marquéz V, Nierhaus KH, de Pouplana LR, Schimmel P. Trna and synthetases Protein Synthesis and Ribosome Structure. 145-184. DOI: 10.1002/3527603433.ch4  1
2005 Swairjo MA, Reddy RR, Lee B, Van Lanen SG, Brown S, de Crécy-Lagard V, Iwata-Reuyl D, Schimmel P. Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 945-8. PMID 16511203 DOI: 10.1107/S1744309105029246  1
2005 Waas WF, de Crécy-Lagard V, Schimmel P. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. The Journal of Biological Chemistry. 280: 37616-22. PMID 16162496 DOI: 10.1074/jbc.M506939200  1
2005 Reader JS, Ordoukhanian PT, Kim JG, de Crécy-Lagard V, Hwang I, Farrand S, Schimmel P. Major biocontrol of plant tumors targets tRNA synthetase. Science (New York, N.Y.). 309: 1533. PMID 16141066 DOI: 10.1126/science.1116841  1
2005 Ewalt KL, Yang XL, Otero FJ, Liu J, Slike B, Schimmel P. Variant of human enzyme sequesters reactive intermediate. Biochemistry. 44: 4216-21. PMID 15766249 DOI: 10.1021/bi048116l  1
2005 Swairjo MA, Schimmel PR. Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 102: 988-93. PMID 15657145 DOI: 10.1073/pnas.0409024102  1
2005 Bacher JM, de Crécy-Lagard V, Schimmel PR. Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 102: 1697-701. PMID 15647356 DOI: 10.1073/pnas.0409064102  1
2005 Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P. VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. The Journal of Biological Chemistry. 280: 2405-8. PMID 15579907 DOI: 10.1074/jbc.C400431200  1
2004 Tamura K, Schimmel P. Non-enzymatic aminoacylation of an RNA minihelix with an aminoacyl phosphate oligonucleotide. Nucleic Acids Symposium Series (2004). 269-70. PMID 17150582 DOI: 10.1093/nass/48.1.269  1
2004 Metzgar D, Bacher JM, Pezo V, Reader J, Döring V, Schimmel P, Marlière P, de Crécy-Lagard V. Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering. Nucleic Acids Research. 32: 5780-90. PMID 15514111 DOI: 10.1093/nar/gkh881  1
2004 Schimmel P, Ewalt K. Translation silenced by fused pair of tRNA synthetases. Cell. 119: 147-8. PMID 15479630 DOI: 10.1016/j.cell.2004.10.001  1
2004 Schimmel P, Beebe K. Molecular biology: genetic code seizes pyrrolysine. Nature. 431: 257-8. PMID 15372017 DOI: 10.1038/431257a  1
2004 Tang HL, Yeh LS, Chen NK, Ripmaster T, Schimmel P, Wang CC. Translation of a yeast mitochondrial tRNA synthetase initiated at redundant non-AUG codons. The Journal of Biological Chemistry. 279: 49656-63. PMID 15358761 DOI: 10.1074/jbc.M408081200  1
2004 Tamura K, Schimmel P. Chiral-selective aminoacylation of an RNA minihelix. Science (New York, N.Y.). 305: 1253. PMID 15333830 DOI: 10.1126/science.1099141  1
2004 Schimmel P, Yang XL. Two classes give lessons about CCA. Nature Structural & Molecular Biology. 11: 807-8. PMID 15332079 DOI: 10.1038/nsmb0904-807  1
2004 Hendrickson TL, de Crécy-Lagard V, Schimmel P. Incorporation of nonnatural amino acids into proteins. Annual Review of Biochemistry. 73: 147-76. PMID 15189139 DOI: 10.1146/annurev.biochem.73.012803.092429  1
2004 Pezo V, Metzgar D, Hendrickson TL, Waas WF, Hazebrouck S, Döring V, Marlière P, Schimmel P, De Crécy-Lagard V. Artificially ambiguous genetic code confers growth yield advantage. Proceedings of the National Academy of Sciences of the United States of America. 101: 8593-7. PMID 15163798 DOI: 10.1073/pnas.0402893101  1
2004 Yang XL, Schimmel P, Ewalt KL. Relationship of two human tRNA synthetases used in cell signaling. Trends in Biochemical Sciences. 29: 250-6. PMID 15130561 DOI: 10.1016/j.tibs.2004.03.002  1
2004 Beebe K, Merriman E, Ribas De Pouplana L, Schimmel P. A domain for editing by an archaebacterial tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 101: 5958-63. PMID 15079065 DOI: 10.1073/pnas.0401530101  1
2004 Lovato MA, Swairjo MA, Schimmel P. Positional recognition of a tRNA determinant dependent on a peptide insertion. Molecular Cell. 13: 843-51. PMID 15053877 DOI: 10.1016/S1097-2765(04)00125-X  1
2004 Swairjo MA, Otero FJ, Yang XL, Lovato MA, Skene RJ, McRee DE, Ribas de Pouplana L, Schimmel P. Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition. Molecular Cell. 13: 829-41. PMID 15053876 DOI: 10.1016/S1097-2765(04)00126-1  1
2004 Liu J, Shue E, Ewalt KL, Schimmel P. A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase. Nucleic Acids Research. 32: 719-27. PMID 14757836 DOI: 10.1093/nar/gkh240  1
2004 Reader JS, Metzgar D, Schimmel P, de Crécy-Lagard V. Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. The Journal of Biological Chemistry. 279: 6280-5. PMID 14660578 DOI: 10.1074/jbc.M310858200  1
2004 De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J. Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. The Journal of Biological Chemistry. 279: 8111-5. PMID 14660562 DOI: 10.1074/jbc.M311449200  1
2003 Yang XL, Otero FJ, Skene RJ, McRee DE, Schimmel P, Ribas de Pouplana L. Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. Proceedings of the National Academy of Sciences of the United States of America. 100: 15376-80. PMID 14671330 DOI: 10.1073/pnas.2136794100  1
2003 Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P. Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 14903-7. PMID 14630953 DOI: 10.1073/pnas.2436330100  1
2003 Nordin BE, Schimmel P. Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases. Biochemistry. 42: 12989-97. PMID 14596614 DOI: 10.1021/bi035052q  1
2003 Beebe K, Merriman E, Schimmel P. Structure-specific tRNA determinants for editing a mischarged amino acid. The Journal of Biological Chemistry. 278: 45056-61. PMID 12949076 DOI: 10.1074/jbc.M307080200  1
2003 Tamura K, Schimmel P. Peptide synthesis with a template-like RNA guide and aminoacyl phosphate adaptors. Proceedings of the National Academy of Sciences of the United States of America. 100: 8666-9. PMID 12857953 DOI: 10.1073/pnas.1432909100  1
2003 Frugier M, Giege R, Schimmel P. RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 100: 7471-5. PMID 12796515 DOI: 10.1073/pnas.1332771100  1
2003 Schimmel P, Tamura K. tRNA structure goes from L to lambda. Cell. 113: 276-8. PMID 12732135 DOI: 10.1016/S0092-8674(03)00313-1  1
2003 Wang CC, Chang KJ, Tang HL, Hsieh CJ, Schimmel P. Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide. Biochemistry. 42: 1646-51. PMID 12578378 DOI: 10.1021/bi025964c  1
2003 Beebe K, Ribas De Pouplana L, Schimmel P. Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability. The Embo Journal. 22: 668-75. PMID 12554667 DOI: 10.1093/emboj/cdg065  1
2003 Bishop AC, Beebe K, Schimmel PR. Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 100: 490-4. PMID 12515858 DOI: 10.1073/pnas.0237335100  1
2003 Yaug XL, Liu J, Skene RJ, McRee DE, Schimmel P. Crystal structure of an EMAP-II-like cytokine released from a human tRNA synthetase Helvetica Chimica Acta. 86: 1246-1257. DOI: 10.1002/hlca.200390107  1
2002 Kushiro T, Schimmel P. Trbp111 selectively binds a noncovalently assembled tRNA-like structure. Proceedings of the National Academy of Sciences of the United States of America. 99: 16631-5. PMID 12481025 DOI: 10.1073/pnas.262667999  1
2002 Liu J, Yang XL, Ewalt KL, Schimmel P. Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine. Biochemistry. 41: 14232-7. PMID 12450387 DOI: 10.1021/bi0205395  1
2002 Cen S, Javanbakht H, Kim S, Shiba K, Craven R, Rein A, Ewalt K, Schimmel P, Musier-Forsyth K, Kleiman L. Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs. Journal of Virology. 76: 13111-5. PMID 12438642 DOI: 10.1128/JVI.76.24.13111-13115.2002  1
2002 Yang XL, Skene RJ, McRee DE, Schimmel P. Crystal structure of a human aminoacyl-tRNA synthetase cytokine. Proceedings of the National Academy of Sciences of the United States of America. 99: 15369-74. PMID 12427973 DOI: 10.1073/pnas.242611799  1
2002 Ewalt KL, Schimmel P. Activation of angiogenic signaling pathways by two human tRNA synthetases Biochemistry. 41: 13344-13349. PMID 12416978 DOI: 10.1021/bi020537k  1
2002 Schimmel P. The protein synthesis world Trends in Biochemical Sciences. 27: 505-506. PMID 12368085 DOI: 10.1016/S0968-0004(02)02203-X  1
2002 Nangle LA, De Crécy Lagard V, Döring V, Schimmel P. Genetic code ambiguity: Cell viability related to severity of editing defects in mutant tRNA synthetases Journal of Biological Chemistry. 277: 45729-45733. PMID 12244062 DOI: 10.1074/jbc.M208093200  1
2002 Otani A, Kinder K, Ewalt K, Otero FJ, Schimmel P, Friedlander M. Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nature Medicine. 8: 1004-10. PMID 12145646 DOI: 10.1038/nm744  1
2002 Tamura K, Schimmel P. Ribozyme programming extends the protein code. Nature Biotechnology. 20: 669-70. PMID 12089548 DOI: 10.1038/nbt0702-669  1
2002 Bishop AC, Xu J, Johnson RC, Schimmel P, de Crécy-Lagard V. Identification of the tRNA-dihydrouridine synthase family. The Journal of Biological Chemistry. 277: 25090-5. PMID 11983710 DOI: 10.1074/jbc.M203208200  1
2002 Nordin BE, Schimmel P. Plasticity of recognition of the 3'-end of mischarged tRNA by class I aminoacyl-tRNA synthetases. The Journal of Biological Chemistry. 277: 20510-7. PMID 11923317 DOI: 10.1074/jbc.M202023200  1
2002 Hendrickson TL, Nomanbhoy TK, De Crécy-Lagard V, Fukai S, Nureki O, Yokoyama S, Schimmel P. Mutational separation of two pathways for editing by a class I tRNA synthetase Molecular Cell. 9: 353-362. PMID 11864608 DOI: 10.1016/S1097-2765(02)00449-5  1
2002 Bishop AC, Nomanbhoy TK, Schimmel P. Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 99: 585-90. PMID 11782529 DOI: 10.1073/pnas.012611299  1
2002 Wakasugi K, Slike BM, Hood J, Otani A, Ewalt KL, Friedlander M, Cheresh DA, Schimmel P. A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 173-7. PMID 11773626 DOI: 10.1073/pnas.012602099  1
2002 Otani A, Slike BM, Dorrell MI, Hood J, Kinder K, Ewalt KL, Cheresh D, Schimmel P, Friedlander M. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 178-83. PMID 11773625 DOI: 10.1073/pnas.012601899  1
2001 Schimmel P, Ribas de Pouplana L. Formation of two classes of tRNA synthetases in relation to editing functions and genetic code. Cold Spring Harbor Symposia On Quantitative Biology. 66: 161-6. PMID 12762018  1
2001 Ribas de Pouplana L, Brown JR, Schimmel P. Structure-based phylogeny of class IIa tRNA synthetases in relation to an unusual biochemistry. Journal of Molecular Evolution. 53: 261-8. PMID 11675586 DOI: 10.1007/s002390010216  1
2001 Ribas de Pouplana L, Schimmel P. Aminoacyl-tRNA synthetases: potential markers of genetic code development. Trends in Biochemical Sciences. 26: 591-6. PMID 11590011 DOI: 10.1016/S0968-0004(01)01932-6  1
2001 Alexander RW, Schimmel P. Domain-domain communication in aminoacyl-tRNA synthetases Progress in Nucleic Acid Research and Molecular Biology. 69: 317-349. PMID 11550797  1
2001 Lovato MA, Chihade JW, Schimmel P. Translocation within the acceptor helix of a major tRNA identity determinant. The Embo Journal. 20: 4846-53. PMID 11532948 DOI: 10.1093/emboj/20.17.4846  1
2001 Nomanbhoy TK, Schimmel P. Active site of an aminoacyl-tRNA synthetase dissected by energy-transfer-dependent fluorescence Bioorganic and Medicinal Chemistry Letters. 11: 1485-1491. PMID 11412966 DOI: 10.1016/S0960-894X(01)00127-5  1
2001 Fàbrega C, Farrow MA, Mukhopadhyay B, de Crécy-Lagard V, Ortiz AR, Schimmel P. An aminoacyl tRNA synthetase whose sequence fits into neither of the two known classes. Nature. 411: 110-4. PMID 11333988 DOI: 10.1038/35075121  1
2001 Döring V, Mootz HD, Nangle LA, Hendrickson TL, de Crécy-Lagard V, Schimmel P, Marlière P. Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway. Science (New York, N.Y.). 292: 501-4. PMID 11313495 DOI: 10.1126/science.1057718  1
2001 Farrow MA, Schimmel P. Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid. Biochemistry. 40: 4478-83. PMID 11284704 DOI: 10.1021/bi0024052  1
2001 Nomanbhoy T, Morales AJ, Abraham AT, Vörtler CS, Giegé R, Schimmel P. Simultaneous binding of two proteins to opposite sides of a single transfer RNA. Nature Structural Biology. 8: 344-8. PMID 11276256 DOI: 10.1038/86228  1
2001 Ribas de Pouplana L, Schimmel P. Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem. Cell. 104: 191-3. PMID 11269237 DOI: 10.1016/S0092-8674(01)00204-5  1
2001 Ribas de Pouplana L, Schimmel P. Operational RNA code for amino acids in relation to genetic code in evolution. The Journal of Biological Chemistry. 276: 6881-4. PMID 11238440 DOI: 10.1074/jbc.R000032200  1
2001 Tamura K, Schimmel P. Oligonucleot ide-directed peptide synthesis in a ribosome- and ribozyme-free system Proceedings of the National Academy of Sciences of the United States of America. 98: 1393-1397. PMID 11171961 DOI: 10.1073/pnas.98.4.1393  1
2001 Kelley SO, Steinberg SV, Schimmel P. Fragile T-stem in Disease-associated Human Mitochondrial tRNA Sensitizes Structure to Local and Distant Mutations Journal of Biological Chemistry. 276: 10607-10611. PMID 11110797 DOI: 10.1074/jbc.M008320200  1
2000 Sardesai NY, Stagg SM, Vanloock MS, Harvey SC, Schimmel P. RNA scaffolds for minihelix-based aminoacyl transfer: design of "transpeptizymes". Journal of Biomolecular Structure & Dynamics. 17: 29-37. PMID 22607404 DOI: 10.1080/07391102.2000.10506601  1
2000 Tamura K, Schimmel P. Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA. Nucleic Acids Symposium Series. 251-2. PMID 12903363  1
2000 Schimmel P. Public funding of intellectual curiosity Iubmb Life. 50: 345-346. PMID 11327305 DOI: 10.1080/152165400300089312  1
2000 Swairjo MA, Morales AJ, Wang CC, Ortiz AR, Schimmel P. Crystal structure of Trbp111: A structure-specific tRNA-binding protein Embo Journal. 19: 6287-6298. PMID 11101501  1
2000 Houman F, Rho SB, Zhang J, Shen X, Wang CC, Schimmel P, Martinis SA. A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria Proceedings of the National Academy of Sciences of the United States of America. 97: 13743-13748. PMID 11087829 DOI: 10.1073/pnas.240465597  1
2000 Tao J, Schimmel P. Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives Expert Opinion On Investigational Drugs. 9: 1767-1775. PMID 11060775  1
2000 Chihade JW, Brown JR, Schimmel PR, Ribas De Pouplana L. Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 97: 12153-7. PMID 11035802 DOI: 10.1073/pnas.220388797  1
2000 Kelley SO, Steinberg SV, Schimmel P. Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility Nature Structural Biology. 7: 862-865. PMID 11017193 DOI: 10.1038/79612  1
2000 Schimmel P. Industry benefits from the public funding of intellectual curiosity [1] Nature. 406: 826. PMID 10972266  1
2000 Ribas de Pouplana L, Schimmel P. A view into the origin of life: aminoacyl-tRNA synthetases. Cellular and Molecular Life Sciences : Cmls. 57: 865-70. PMID 10950302  1
2000 Hendrickson TL, Nomanbhoy TK, Schimmel P. Errors from selective disruption of the editing center in a tRNA synthetase Biochemistry. 39: 8180-8186. PMID 10889024 DOI: 10.1021/bi0004798  1
2000 Turner RJ, Lovato M, Schimmel P. One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions Journal of Biological Chemistry. 275: 27681-27688. PMID 10874035 DOI: 10.1074/jbc.M003416200  1
2000 Nomanbhoy TK, Schimmel PR. Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America. 97: 5119-5122. PMID 10792042  1
2000 Schimmel P, Ribas De Pouplana L. Footprints of aminoacyl-tRNA synthetases are everywhere. Trends in Biochemical Sciences. 25: 207-9. PMID 10782085 DOI: 10.1016/S0968-0004(00)01553-X  1
2000 Wang CC, Morales AJ, Schimmel P. Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase Journal of Biological Chemistry. 275: 17180-17186. PMID 10747983 DOI: 10.1074/jbc.M001057200  1
2000 Tao J, Wendler P, Connelly G, Lim A, Zhang J, King M, Li T, Silverman JA, Schimmel PR, Tally FP. Drug target validation: Lethal infection blocked by inducible peptide Proceedings of the National Academy of Sciences of the United States of America. 97: 783-786. PMID 10639157 DOI: 10.1073/pnas.97.2.783  1
2000 Schimmel P, Kelley SO. Exiting an RNA world Nature Structural Biology. 7: 5-7. PMID 10625414 DOI: 10.1038/71194  1
1999 Farrow MA, Nordin BE, Schimmel P. Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase. Biochemistry. 38: 16898-903. PMID 10606524 DOI: 10.1021/bi9920782  1
1999 Alexander RW, Schimmel P. Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex Biochemistry. 38: 16359-16365. PMID 10587461 DOI: 10.1021/bi991948c  1
1999 Steer BA, Schimmel P. Major anticodon-binding region missing from an archaebacterial tRNA synthetase Journal of Biological Chemistry. 274: 35601-35606. PMID 10585437 DOI: 10.1074/jbc.274.50.35601  1
1999 Steer BA, Schimmel P. Domain-domain communication in a miniature archaebacterial tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America. 96: 13644-13649. PMID 10570126 DOI: 10.1073/pnas.96.24.13644  1
1999 Nomanbhoy TK, Hendrickson TL, Schimmel P. Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis Molecular Cell. 4: 519-528. PMID 10549284 DOI: 10.1016/S1097-2765(00)80203-8  1
1999 Chihade JW, Schimmel P. Assembly of a catalytic unit for RNA microhelix aminoacylation using nonspecific RNA binding domains Proceedings of the National Academy of Sciences of the United States of America. 96: 12316-12321. PMID 10535919 DOI: 10.1073/pnas.96.22.12316  1
1999 Sardesai NY, Green R, Schimmel P. Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix Biochemistry. 38: 12080-12088. PMID 10508412 DOI: 10.1021/bi991126f  1
1999 Wakasugi K, Schimmel P. Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase Journal of Biological Chemistry. 274: 23155-23159. PMID 10438485 DOI: 10.1074/jbc.274.33.23155  1
1999 Morales AJ, Swairjo MA, Schimmel P. Structure-specific tRNA-binding protein from the extreme thermophile Aquifex aeolicus Embo Journal. 18: 3475-3483. PMID 10369686 DOI: 10.1093/emboj/18.12.3475  1
1999 Wang CC, Schimmel P. Species barrier to RNA recognition overcome with nonspecific RNA binding domains Journal of Biological Chemistry. 274: 16508-16512. PMID 10347214 DOI: 10.1074/jbc.274.23.16508  1
1999 Schimmel P, Wang CC. Getting tRNA synthetases into the nucleus Trends in Biochemical Sciences. 24: 127-128. PMID 10322413 DOI: 10.1016/S0968-0004(99)01369-9  1
1999 Steer BA, Schimmel P. Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases Biochemistry. 38: 4965-4971. PMID 10213598 DOI: 10.1021/bi990038s  1
1999 Wakasugi K, Schimmel P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase Science. 284: 147-151. PMID 10102815 DOI: 10.1126/science.284.5411.147  1
1999 Nordin BE, Schimmel P. RNA determinants for translational editing. Mischarging a minihelix substrate by a tRNA synthetase. The Journal of Biological Chemistry. 274: 6835-8. PMID 10066735 DOI: 10.1074/jbc.274.11.6835  1
1999 Schimmel P, Ribas de Pouplana L. Genetic code origins: experiments confirm phylogenetic predictions and may explain a puzzle. Proceedings of the National Academy of Sciences of the United States of America. 96: 327-8. PMID 9892630 DOI: 10.1073/pnas.96.2.327  1
1999 Musier-Forsyth K, Schimmel P. Atomic determinants for aminoacylation of RNA minihelices and relationship to genetic code Accounts of Chemical Research. 32: 368-375. DOI: 10.1021/ar970148w  1
1998 Schimmel P, Tao J, Hill J. Aminoacyl tRNA synthetases as targets for new anti-infectives Faseb Journal. 12: 1599-1609. PMID 9837850  1
1998 Alexander RW, Nordin BE, Schimmel P. Activation of microhelix charging by localized helix destabilization. Proceedings of the National Academy of Sciences of the United States of America. 95: 12214-9. PMID 9770466 DOI: 10.1073/pnas.95.21.12214  1
1998 Ribas de Pouplana L, Turner RJ, Steer BA, Schimmel P. Genetic code origins: tRNAs older than their synthetases? Proceedings of the National Academy of Sciences of the United States of America. 95: 11295-300. PMID 9736730  1
1998 Ribas de Pouplana L, Buechter D, Sardesai NY, Schimmel P. Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains. The Embo Journal. 17: 5449-57. PMID 9736622 DOI: 10.1093/emboj/17.18.5449  1
1997 Ribas de Pouplana L, Schimmel P. Reconstruction of quaternary structures of class II tRNA synthetases by rational mutagenensis of a conserved domain. Biochemistry. 36: 15041-8. PMID 9398230 DOI: 10.1021/bi971788+  1
1997 Nair S, Ribas de Pouplana L, Houman F, Avruch A, Shen X, Schimmel P. Species-specific tRNA recognition in relation to tRNA synthetase contact residues. Journal of Molecular Biology. 269: 1-9. PMID 9192996 DOI: 10.1006/jmbi.1997.1025  1
1996 Ribas de Pouplana L, Auld DS, Kim S, Schimmel P. A mechanism for reducing entropic cost of induced fit in protein--RNA recognition. Biochemistry. 35: 8095-102. PMID 8679560 DOI: 10.1021/bi960256a  1
1996 Ribas de Pouplana L, Frugier M, Quinn CL, Schimmel P. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. Proceedings of the National Academy of Sciences of the United States of America. 93: 166-70. PMID 8552597 DOI: 10.1073/pnas.93.1.166  1
1995 Schimmel P, Ribas de Pouplana L. Transfer RNA: from minihelix to genetic code. Cell. 81: 983-6. PMID 7600584  1
1994 Kim S, Ribas de Pouplana L, Schimmel P. An RNA binding site in a tRNA synthetase with a reduced set of amino acids. Biochemistry. 33: 11040-5. PMID 7522052  1
1993 Ribas de Pouplana L, Buechter DD, Davis MW, Schimmel P. Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure. Protein Science : a Publication of the Protein Society. 2: 2259-62. PMID 8298469 DOI: 10.1002/pro.5560021225  1
1993 Kim S, Ribas de Pouplana L, Schimmel P. Diversified sequences of peptide epitope for same-RNA recognition. Proceedings of the National Academy of Sciences of the United States of America. 90: 10046-50. PMID 7694278  1
1988 Regan L, Buxbaum L, Hill K, Schimmel P. Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion. The Journal of Biological Chemistry. 263: 18598-600. PMID 3198590  1
1988 Frederick CA, Wang AH, Rich A, Regan L, Schimmel P. Crystallization of a small fragment of an aminoacyl tRNA synthetase. Journal of Molecular Biology. 203: 521-2. PMID 3058989 DOI: 10.1016/0022-2836(88)90019-8  1
1987 Regan L, Bowie J, Schimmel P. Polypeptide sequences essential for RNA recognition by an enzyme. Science (New York, N.Y.). 235: 1651-3. PMID 2435005  1
1986 Regan L, Dignam JD, Schimmel P. A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each. The Journal of Biological Chemistry. 261: 5241-4. PMID 2420799  1
1985 Jasin M, Regan L, Schimmel P. Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity. The Journal of Biological Chemistry. 260: 2226-30. PMID 3882689  1
1984 Schimmel P, Jasin M, Regan L. Size polymorphism and the structure of aminoacyl-tRNA synthetases. Federation Proceedings. 43: 2987-90. PMID 6389183  1
1984 Jasin M, Regan L, Schimmel P. Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site. Cell. 36: 1089-95. PMID 6200234  1
1983 Jasin M, Regan L, Schimmel P. Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase. Nature. 306: 441-7. PMID 6358898  1
1968 Schimmel PR, Flory PJ. Conformational energies and configurational statistics of copolypeptides containing L-proline. Journal of Molecular Biology. 34: 105-20. PMID 5760450  1
1967 Flory PJ, Schimmel PR. Dipole moments in relation to configuration of polypeptide chains. Journal of the American Chemical Society. 89: 6807-13. PMID 6064350  1
1967 Hammes GG, Schimmel PR. Relaxation spectra of enzymatic reactions. The Journal of Physical Chemistry. 71: 917-23. PMID 6045206  1
1967 Schimmel PR, Flory PJ. Conformational energy and configurational statistics of poly-L-proline. Proceedings of the National Academy of Sciences of the United States of America. 58: 52-9. PMID 5231619  1
1965 Fasella P, Hammes GG, Schimmel PR. A Sephadex dialysis method of determining small molecule-macromolecule binding constants. Biochimica Et Biophysica Acta. 103: 708-10. PMID 5859855  1
1965 Hammes GG, Schimmel PR. Equilibrium measurements of the binding of cytidine 3'-phosphate to ribonuclease. Journal of the American Chemical Society. 87: 4665-9. PMID 5844451  1
1965 Cathou RE, Hammes GG, Schimmel PR. Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. Biochemistry. 4: 2687-90. PMID 4286548  1
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