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Matthew R. Redinbo - Publications

Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Structural Studies of Dynamic Cellular Processes

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ervin SM, Simpson JB, Gibbs ME, Creekmore BC, Lim L, Walton WG, Gharaibeh RZ, Redinbo MR. Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry. PMID 32993284 DOI: 10.1021/acs.biochem.0c00711  0.36
2020 Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, ... ... Redinbo MR, et al. Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32170007 DOI: 10.1073/pnas.1918095117  0.96
2020 Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schön A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, et al. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry. PMID 32160459 DOI: 10.1021/acs.jmedchem.0c00012  0.36
2020 Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, ... ... Redinbo MR, et al. Targeting the pregnane X receptor using microbial metabolite mimicry. Embo Molecular Medicine. e11621. PMID 32153125 DOI: 10.15252/emmm.201911621  0.36
2019 Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. Acs Chemical Biology. PMID 31774274 DOI: 10.1021/acschembio.9b00788  0.36
2019 Ervin SM, Hanley RP, Lim L, Walton WG, Pearce KH, Bhatt AP, James LI, Redinbo MR. Targeting regorafenib-induced toxicity through inhibition of gut microbial β-glucuronidases. Acs Chemical Biology. PMID 31663730 DOI: 10.1021/acschembio.9b00663  0.36
2019 Creekmore BC, Gray JH, Walton WG, Biernat KA, Little MS, Xu Y, Liu J, Gharaibeh RZ, Redinbo MR. Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure. Msystems. 4. PMID 31455640 DOI: 10.1128/mSystems.00452-19  0.36
2019 Pellock SJ, Walton WG, Redinbo MR. Selecting a Single Stereocenter: The Molecular Nuances that Differentiate β-Hexuronidases in the Human Gut Microbiome. Biochemistry. PMID 30729778 DOI: 10.1021/acs.biochem.8b01285  0.36
2019 Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR. Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases. Scientific Reports. 9: 825. PMID 30696850 DOI: 10.1038/s41598-018-36069-w  0.44
2019 Pellock SJ, Walton WG, Ervin SM, Torres-Rivera D, Creekmore BC, Bergan G, Dunn ZD, Li B, Tripathy A, Redinbo MR. Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome. Journal of Molecular Biology. PMID 30658055 DOI: 10.1016/j.jmb.2019.01.013  0.36
2018 Pellock SJ, Walton WG, Biernat KA, Torres-Rivera D, Creekmore BC, Xu Y, Liu J, Tripathy A, Stewart LJ, Redinbo MR. . The Journal of Biological Chemistry. PMID 30301767 DOI: 10.1074/jbc.RA118.005414  0.36
2018 Little MS, Ervin SM, Walton WG, Tripathy A, Xu Y, Liu J, Redinbo MR. Active Site Flexibility Revealed in Crystal Structures of Parabacteroides merdae β-Glucuronidase from the Human Gut Microbiome. Protein Science : a Publication of the Protein Society. PMID 30230652 DOI: 10.1002/pro.3507  0.36
2018 Yu Z, Deslouches B, Walton WG, Redinbo MR, Di YP. Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus. Plos One. 13: e0203621. PMID 30216370 DOI: 10.1371/journal.pone.0203621  0.36
2018 Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. Acs Central Science. 4: 868-879. PMID 30062115 DOI: 10.1021/acscentsci.8b00239  0.36
2018 Kim CS, Ahmad S, Wu T, Walton WG, Redinbo MR, Tarran R. SPLUNC1 is an allosteric modulator of the epithelial sodium channel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29295861 DOI: 10.1096/fj.201701126R  0.36
2017 Little MS, Pellock SJ, Walton WG, Tripathy A, Redinbo MR. Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae. Proceedings of the National Academy of Sciences of the United States of America. PMID 29269393 DOI: 10.1073/pnas.1716241115  0.36
2017 Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR. An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. Structure (London, England : 1993). PMID 28578872 DOI: 10.1016/j.str.2017.05.003  0.4
2017 Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA. Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates. Nucleic Acids Research. PMID 28369583 DOI: 10.1093/nar/gkx214  0.44
2017 Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R. Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor. Nature Communications. 8: 14118. PMID 28165446 DOI: 10.1038/ncomms14118  0.36
2016 Ahmad S, Tyrrell J, Walton WG, Tripathy A, Redinbo MR, Tarran R. SPLUNC1 has Antimicrobial and Antibiofilm Activity against Burkholderia cepacia Complex. Antimicrobial Agents and Chemotherapy. PMID 27458217 DOI: 10.1128/AAC.00975-16  0.36
2016 Walton WG, Ahmad S, Little MR, Kim CS, Tyrrell JS, Lin Q, Di YP, Tarran R, Redinbo MR. Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1. Biochemistry. PMID 27145151 DOI: 10.1021/acs.biochem.6b00271  0.36
2016 Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA. Post-Translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A. Journal of the American Chemical Society. PMID 27088303 DOI: 10.1021/jacs.5b13529  1
2016 Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MM, Dvorak Z, Mani S. Acetylation of Lysine 109 Modulates Pregnane X Receptor DNA Binding and Transcriptional Activity. Biochimica Et Biophysica Acta. PMID 26855179 DOI: 10.1016/j.bbagrm.2016.01.006  1
2016 Pollet RM, Ingle JD, Hymes JP, Eakes TC, Eto KY, Kwong SM, Ramsay JP, Firth N, Redinbo MR. Processing of Non-Conjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci. Journal of Bacteriology. PMID 26728193 DOI: 10.1128/JB.00832-15  0.4
2015 Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, ... ... Redinbo MR, et al. Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49. PMID 26364932 DOI: 10.1016/j.chembiol.2015.08.005  1
2014 Redinbo MR. The microbiota, chemical symbiosis, and human disease. Journal of Molecular Biology. 426: 3877-91. PMID 25305474 DOI: 10.1016/j.jmb.2014.09.011  1
2014 Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 41: 296-310. PMID 25065623 DOI: 10.1016/j.immuni.2014.06.014  1
2014 McLaughlin KJ, Nash RP, Redinbo MR. Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1. Journal of Bacteriology. 196: 3082-90. PMID 24936053 DOI: 10.1128/JB.01496-14  1
2014 Tarran R, Redinbo MR. Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration. The International Journal of Biochemistry & Cell Biology. 52: 130-5. PMID 24631954 DOI: 10.1016/j.biocel.2014.03.002  1
2014 Mani S, Boelsterli UA, Redinbo MR. Understanding and modulating mammalian-microbial communication for improved human health. Annual Review of Pharmacology and Toxicology. 54: 559-80. PMID 24160697 DOI: 10.1146/annurev-pharmtox-011613-140007  1
2014 Saitta KS, Zhang C, Lee KK, Fujimoto K, Redinbo MR, Boelsterli UA. Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 44: 28-35. PMID 23829165 DOI: 10.3109/00498254.2013.811314  1
2013 Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ, Tarran R. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L990-L1001. PMID 24124190 DOI: 10.1152/ajplung.00103.2013  1
2013 Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proceedings of the National Academy of Sciences of the United States of America. 110: 15973-8. PMID 24043776 DOI: 10.1073/pnas.1311999110  1
2013 Cheng Y, Johnson MD, Burillo-Kirch C, Mocny JC, Anderson JE, Garrett CK, Redinbo MR, Thomas CE. Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation. Infection and Immunity. 81: 4280-9. PMID 24002068 DOI: 10.1128/IAI.00493-13  1
2013 Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC. An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 110: 15055-60. PMID 23980177 DOI: 10.1073/pnas.1307217110  1
2013 Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR. Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular Pharmacology. 84: 208-17. PMID 23690068 DOI: 10.1124/mol.113.085852  1
2013 Wallace BD, Redinbo MR. The human microbiome is a source of therapeutic drug targets. Current Opinion in Chemical Biology. 17: 379-84. PMID 23680493 DOI: 10.1016/j.cbpa.2013.04.011  1
2013 Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR. Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Journal of Molecular Biology. 425: 2561-77. PMID 23602807 DOI: 10.1016/j.jmb.2013.04.012  1
2013 Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S. Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. The Journal of Biological Chemistry. 288: 13655-68. PMID 23525103 DOI: 10.1074/jbc.M113.455485  1
2013 Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR. Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 110: 2804-9. PMID 23359708 DOI: 10.1073/pnas.1219701110  1
2013 Mani S, Dou W, Redinbo MR. PXR antagonists and implication in drug metabolism. Drug Metabolism Reviews. 45: 60-72. PMID 23330542 DOI: 10.3109/03602532.2012.746363  1
2013 Porsch EA, Johnson MD, Broadnax AD, Garrett CK, Redinbo MR, St Geme JW. Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility. Journal of Bacteriology. 195: 886-95. PMID 23243304 DOI: 10.1128/JB.02186-12  1
2013 Wallace BD, Redinbo MR. Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews. 45: 79-100. PMID 23210723 DOI: 10.3109/03602532.2012.740049  1
2013 Boelsterli UA, Redinbo MR, Saitta KS. Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies. Toxicological Sciences : An Official Journal of the Society of Toxicology. 131: 654-67. PMID 23091168 DOI: 10.1093/toxsci/kfs310  1
2012 Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A. Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711. PMID 22954034 DOI: 10.1021/bi301026c  1
2012 Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4348-59. PMID 22798424 DOI: 10.1096/fj.12-207431  1
2012 Nash RP, McNamara DE, Ballentine WK, Matson SW, Redinbo MR. Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids. Biochemical and Biophysical Research Communications. 424: 697-703. PMID 22796221 DOI: 10.1016/j.bbrc.2012.07.012  1
2012 LoGuidice A, Wallace BD, Bendel L, Redinbo MR, Boelsterli UA. Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 447-54. PMID 22328575 DOI: 10.1124/jpet.111.191122  1
2012 Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. Biochemistry. 51: 19-31. PMID 22185585 DOI: 10.1021/bi2011674  1
2011 Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR. Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner. Plos One. 6: e29629. PMID 22242136 DOI: 10.1371/journal.pone.0029629  1
2011 Cheng Y, Frazier M, Lu F, Cao X, Redinbo MR. Crystal structure of the plant epigenetic protein arginine methyltransferase 10. Journal of Molecular Biology. 414: 106-22. PMID 21986201 DOI: 10.1016/j.jmb.2011.09.040  1
2011 Cheng Y, Redinbo MR. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Science : a Publication of the Protein Society. 20: 1713-9. PMID 21805522 DOI: 10.1002/pro.706  1
2011 Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE. A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Current Chemical Genomics. 5: 13-20. PMID 21643506 DOI: 10.2174/1875397301105010013  1
2011 Edwards JS, Kumbhar A, Roberts A, Hemmert AC, Edwards CC, Potter PM, Redinbo MR. Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Biotechnology Progress. 27: 863-9. PMID 21509954 DOI: 10.1002/btpr.604  1
2011 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, ... Redinbo MR, et al. Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. Plos One. 6: e17441. PMID 21445272 DOI: 10.1371/journal.pone.0017441  1
2011 Nash RP, Niblock FC, Redinbo MR. Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme. Febs Letters. 585: 1216-22. PMID 21439279 DOI: 10.1016/j.febslet.2011.03.043  1
2011 Lomino JV, Tripathy A, Redinbo MR. Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization. Journal of Bacteriology. 193: 2089-96. PMID 21398546 DOI: 10.1128/JB.01231-10  1
2011 Cheng Y, McNamara DE, Miley MJ, Nash RP, Redinbo MR. Functional characterization of the multidomain F plasmid TraI relaxase-helicase. The Journal of Biological Chemistry. 286: 12670-82. PMID 21288910 DOI: 10.1074/jbc.M110.207563  1
2010 Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.). 330: 831-5. PMID 21051639 DOI: 10.1126/science.1191175  1
2010 Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, et al. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 427-41. PMID 20931200 DOI: 10.1007/s00335-010-9284-4  1
2010 Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 49: 8398-414. PMID 20799687 DOI: 10.1021/bi100698n  1
2010 Nash RP, Habibi S, Cheng Y, Lujan SA, Redinbo MR. The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. Nucleic Acids Research. 38: 5929-43. PMID 20448025 DOI: 10.1093/nar/gkq303  1
2010 Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences of the United States of America. 107: 1065-70. PMID 20080557 DOI: 10.1073/pnas.0911616107  1
2010 Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR. Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Molecular Pharmacology. 77: 508-16. PMID 20051531 DOI: 10.1124/mol.109.062356  1
2010 Radominska-Pandya A, Bratton SM, Redinbo MR, Miley MJ. The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families. Drug Metabolism Reviews. 42: 133-44. PMID 19821783 DOI: 10.3109/03602530903209049  1
2010 Hemmert AC, Redinbo MR. A structural examination of agrochemical processing by human carboxylesterase 1 Journal of Pesticide Science. 35: 250-256. DOI: 10.1584/jpestics.R10-05  1
2010 Orans J, Johnson MDL, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1065-1070) DOI:10.1073/pnas.0911616107) Proceedings of the National Academy of Sciences of the United States of America. 107: 5260. DOI: 10.1073/pnas.1000441107  1
2009 Ekins S, Kortagere S, Iyer M, Reschly EJ, Lill MA, Redinbo MR, Krasowski MD. Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. Plos Computational Biology. 5: e1000594. PMID 20011107 DOI: 10.1371/journal.pcbi.1000594  1
2009 Kennedy SA, Frazier ML, Steiniger M, Mast AM, Marzluff WF, Redinbo MR. Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. Journal of Molecular Biology. 392: 115-28. PMID 19576221 DOI: 10.1016/j.jmb.2009.06.062  1
2009 Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharmaceutical Research. 26: 1807-15. PMID 19415465 DOI: 10.1007/s11095-009-9901-7  1
2009 Guogas LM, Kennedy SA, Lee JH, Redinbo MR. A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. Journal of Molecular Biology. 386: 554-68. PMID 19136009 DOI: 10.1016/j.jmb.2008.12.057  1
2008 Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Molecular Pharmacology. 74: 1512-20. PMID 18768384 DOI: 10.1124/mol.108.050732  1
2008 Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR. Active nuclear receptors exhibit highly correlated AF-2 domain motions. Plos Computational Biology. 4: e1000111. PMID 18617990 DOI: 10.1371/journal.pcbi.1000111  1
2008 Potts RG, Lujan SA, Redinbo MR. Winning the asymmetric war: new strategies for combating antibacterial resistance. Future Microbiology. 3: 119-23. PMID 18366330 DOI: 10.2217/17460913.3.2.119  1
2008 Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/j.molcel.2007.11.026  1
2008 Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11. Cancer Gene Therapy. 15: 183-92. PMID 18188187 DOI: 10.1038/sj.cgt.7701112  1
2008 Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, ... ... Redinbo M, et al. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Molecular Endocrinology (Baltimore, Md.). 22: 838-57. PMID 18096694 DOI: 10.1210/me.2007-0218  1
2008 Xiong Y, Patana AS, Miley MJ, Zielinska AK, Bratton SM, Miller GP, Goldman A, Finel M, Redinbo MR, Radominska-Pandya A. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 517-22. PMID 18048489 DOI: 10.1124/dmd.107.016469  1
2007 Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/science.1142819  1
2007 Lujan SA, Guogas LM, Ragonese H, Matson SW, Redinbo MR. Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proceedings of the National Academy of Sciences of the United States of America. 104: 12282-7. PMID 17630285 DOI: 10.1073/pnas.0702760104  1
2007 Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR. Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. Journal of Molecular Biology. 369: 498-511. PMID 17442341 DOI: 10.1016/j.jmb.2007.03.066  1
2007 Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2488-95. PMID 17438109 DOI: 10.1158/1078-0432.CCR-06-1592  1
2007 Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR. Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry. 46: 5063-71. PMID 17407327 DOI: 10.1021/bi700246n  1
2007 Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Molecular Endocrinology (Baltimore, Md.). 21: 1028-38. PMID 17327420 DOI: 10.1210/me.2006-0323  1
2007 Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorganic & Medicinal Chemistry. 15: 2156-66. PMID 17215127 DOI: 10.1016/j.bmc.2006.12.026  1
2007 Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. 71: 713-23. PMID 17167034 DOI: 10.1124/mol.105.021683  1
2007 Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene. 26: 258-68. PMID 16819505 DOI: 10.1038/sj.onc.1209788  1
2006 Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR. Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. Journal of Molecular Biology. 363: 201-14. PMID 16962139 DOI: 10.1016/j.jmb.2006.08.025  1
2006 Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89. PMID 16834332 DOI: 10.1021/bi0602821  1
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/j.jmb.2005.10.009  1
2005 Ingraham HA, Redinbo MR. Orphan nuclear receptors adopted by crystallography. Current Opinion in Structural Biology. 15: 708-15. PMID 16263271 DOI: 10.1016/  1
2005 Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. 18: 1371-7. PMID 16167828 DOI: 10.1021/tx050072+  1
2005 Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR. Current Drug Metabolism. 6: 357-67. PMID 16101574 DOI: 10.2174/1389200054633844  1
2005 Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. Journal of Molecular Biology. 352: 165-77. PMID 16081098 DOI: 10.1016/j.jmb.2005.07.016  1
2005 Orans J, Teotico DG, Redinbo MR. The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Molecular Endocrinology (Baltimore, Md.). 19: 2891-900. PMID 15961506 DOI: 10.1210/me.2005-0156  1
2005 Redinbo MR, Potter PM. Mammalian carboxylesterases: from drug targets to protein therapeutics. Drug Discovery Today. 10: 313-25. PMID 15749280 DOI: 10.1016/S1359-6446(05)03383-0  1
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/nsmb910  1
2005 Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Molecular Endocrinology (Baltimore, Md.). 19: 1125-34. PMID 15705662 DOI: 10.1210/me.2004-0346  1
2004 Antony S, Theruvathu JA, Brooks PJ, Lesher DT, Redinbo M, Pommier Y. Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine. Nucleic Acids Research. 32: 5685-92. PMID 15498925 DOI: 10.1093/nar/gkh902  1
2004 Chillemi G, Redinbo M, Bruselles A, Desideri A. Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics Biophysical Journal. 87: 4087-4097. PMID 15347588 DOI: 10.1529/biophysj.104.044925  1
2004 Thapar R, Marzluff WF, Redinbo MR. Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex. Biochemistry. 43: 9401-12. PMID 15260483 DOI: 10.1021/bi036315j  1
2004 Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. Journal of Molecular Biology. 339: 773-84. PMID 15165849 DOI: 10.1016/j.jmb.2004.03.077  1
2004 Redinbo MR. Promiscuity: what protects us, perplexes us. Drug Discovery Today. 9: 431-2. PMID 15109946 DOI: 10.1016/S1359-6446(04)03087-9  1
2004 Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM. Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. Biochemistry. 43: 1874-82. PMID 14967028 DOI: 10.1021/bi035586r  1
2003 Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. Journal of Molecular Biology. 331: 815-28. PMID 12909012 DOI: 10.1016/S0022-2836(03)00795-2  1
2003 Redinbo MR, Bencharit S, Potter PM. Human carboxylesterase 1: from drug metabolism to drug discovery. Biochemical Society Transactions. 31: 620-4. PMID 12773168 DOI: 10.1042/  1
2003 Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chemistry & Biology. 10: 341-9. PMID 12725862 DOI: 10.1016/S1074-5521(03)00071-1  1
2003 Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nature Structural Biology. 10: 349-56. PMID 12679808 DOI: 10.1038/nsb919  1
2003 Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry. 42: 1430-8. PMID 12578355 DOI: 10.1021/bi0268753  1
2003 Chrencik JE, Burgin AB, Pommier Y, Stewart L, Redinbo MR. Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. The Journal of Biological Chemistry. 278: 12461-6. PMID 12533542 DOI: 10.1074/jbc.M212930200  1
2002 Lesher DT, Pommier Y, Stewart L, Redinbo MR. 8-Oxoguanine rearranges the active site of human topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 99: 12102-7. PMID 12209008 DOI: 10.1073/pnas.192282699  1
2002 Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR. Structural insights into CPT-11 activation by mammalian carboxylesterases. Nature Structural Biology. 9: 337-42. PMID 11967565 DOI: 10.1038/nsb790  1
2002 Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Current Opinion in Drug Discovery & Development. 5: 150-8. PMID 11865669  1
2002 Xue Y, Ratcliff GC, Wang H, Davis-Searles PR, Gray MD, Erie DA, Redinbo MR. A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities. Biochemistry. 41: 2901-12. PMID 11863428 DOI: 10.1021/bi0157161  1
2002 Goodwin B, Redinbo MR, Kliewer SA. Regulation of cyp3a gene transcription by the pregnane x receptor. Annual Review of Pharmacology and Toxicology. 42: 1-23. PMID 11807162 DOI: 10.1146/annurev.pharmtox.42.111901.111051  1
2001 Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (New York, N.Y.). 292: 2329-33. PMID 11408620 DOI: 10.1126/science.1060762  1
2000 Redinbo MR, Champoux JJ, Hol WG. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry. 39: 6832-40. PMID 10841763 DOI: 10.1021/bi992690t  1
2000 Wills EA, Redinbo MR, Perfect JR, Del Poeta M. New potential targets for antifungal development Expert Opinion On Therapeutic Targets. 4: 265-296. DOI: 10.1517/14728222.4.3.265  1
1999 Redinbo MR, Stewart L, Champoux JJ, Hol WG. Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. Journal of Molecular Biology. 292: 685-96. PMID 10497031 DOI: 10.1006/jmbi.1999.3065  1
1999 Diller DJ, Redinbo MR, Pohl E, Hol WG. A database method for automated map interpretation in protein crystallography. Proteins. 36: 526-41. PMID 10450094 DOI: 10.1002/(SICI)1097-0134(19990901)36:4<526::AID-PROT16>3.0.CO;2-F  1
1999 Diller DJ, Pohl E, Redinbo MR, Hovey BT, Hol WG. A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps. Proteins. 36: 512-25. PMID 10450093 DOI: 10.1002/(SICI)1097-0134(19990901)36:4<512::AID-PROT15>3.0.CO;2-V  1
1999 Redinbo MR, Champoux JJ, Hol WG. Structural insights into the function of type IB topoisomerases. Current Opinion in Structural Biology. 9: 29-36. PMID 10047584 DOI: 10.1016/S0959-440X(99)80005-0  1
1998 Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ. A model for the mechanism of human topoisomerase I. Science (New York, N.Y.). 279: 1534-41. PMID 9488652 DOI: 10.1126/science.279.5356.1534  1
1998 Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (New York, N.Y.). 279: 1504-13. PMID 9488644 DOI: 10.1126/science.279.5356.1504  1
1996 Redinbo MR, Eide SM, Stone RL, Dixon JE, Yeates TO. Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism. Protein Science : a Publication of the Protein Society. 5: 786-8. PMID 8845770 DOI: 10.1002/pro.5560050425  1
1996 Redinbo MR, Stewart L, Pohl E, Qiu X, Champoux JJ, Hol WGJ. Progress in the structure determination of a human topoisomerase I–DNA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C159-C159. DOI: 10.1107/s0108767396092896  0.44
1994 Redinbo MR, Yeates TO, Merchant S. Plastocyanin: structural and functional analysis. Journal of Bioenergetics and Biomembranes. 26: 49-66. PMID 8027022 DOI: 10.1007/BF00763219  1
1993 Redinbo MR, Yeates TO. Structure determination of plastocyanin from a specimen with a hemihedral twinning fraction of one-half. Acta Crystallographica. Section D, Biological Crystallography. 49: 375-80. PMID 15299512 DOI: 10.1107/S090744499300294X  0.96
1993 Redinbo MR, Cascio D, Choukair MK, Rice D, Merchant S, Yeates TO. The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii. Biochemistry. 32: 10560-7. PMID 8399201  1
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