David Spring, Ph.D. - Publications

Affiliations: 
Chemistry University of Cambridge, Cambridge, England, United Kingdom 
Area:
Organic Chemistry
Website:
http://www-spring.ch.cam.ac.uk

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bargh JD, Isidro-Llobet A, Parker JS, Spring DR. Cleavable linkers in antibody-drug conjugates. Chemical Society Reviews. PMID 31294429 DOI: 10.1039/c8cs00676h  0.32
2019 Sveiczer A, North AJP, Mateu N, Kidd SL, Sore HF, Spring DR. Spirocycles as Rigidified sp-Rich Scaffolds for a Fragment Collection. Organic Letters. PMID 31145629 DOI: 10.1021/acs.orglett.9b01499  0.32
2019 Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 633-634. PMID 30778404 DOI: 10.1039/c8sc90248h  0.32
2019 Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 694-700. PMID 30774870 DOI: 10.1039/c8sc04645j  0.32
2019 Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, ... ... Spring DR, et al. A toolbox of diverse linkers for navigating the cellular efficacy landscape of stapled peptides. Acs Chemical Biology. PMID 30702850 DOI: 10.1021/acschembio.9b00063  0.32
2018 Kidd SL, Osberger TJ, Mateu N, Sore HF, Spring DR. Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections. Frontiers in Chemistry. 6: 460. PMID 30386766 DOI: 10.3389/fchem.2018.00460  0.32
2018 Mateu N, Kidd SL, Kalash L, Sore HF, Madin A, Bender A, Spring DR. Synthesis of structurally diverse N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30011115 DOI: 10.1002/chem.201803143  0.32
2018 Twigg DG, Baldassarre L, Frye EC, Galloway WRJD, Spring DR. Bioinspired Total Synthesis of Bussealin E. Organic Letters. PMID 29498280 DOI: 10.1021/acs.orglett.8b00340  0.32
2017 Kwan TT, Boutureira O, Frye EC, Walsh SJ, Gupta MK, Wallace S, Wu Y, Zhang F, Sore HF, Galloway WRJD, Chin JW, Welch M, Bernardes GJL, Spring DR. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst. Chemical Science. 8: 3871-3878. PMID 28966779 DOI: 10.1039/c6sc05313k  0.32
2017 Sum TH, Sum TJ, Collins S, Galloway WRJD, Twigg DG, Hollfelder F, Spring DR. Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42). Organic & Biomolecular Chemistry. PMID 28513756 DOI: 10.1039/c7ob00804j  0.32
2016 Nie F, Kunciw DL, Wilcke D, Stokes JE, Galloway WR, Bartlett S, Sore HF, Spring DR. A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles. Angewandte Chemie (International Ed. in English). PMID 27484830 DOI: 10.1002/anie.201605460  0.96
2016 Wiedmann MM, Aibara S, Spring DR, Stewart M, Brenton JD. Structural and calorimetric studies demonstrate that the Hepatocyte Nuclear Factor1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence. Journal of Structural Biology. PMID 27346421 DOI: 10.1016/j.jsb.2016.06.018  0.96
2016 Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Scientific Reports. 6: 28528. PMID 27339427 DOI: 10.1038/srep28528  0.96
2016 Chattopadhyay A, O'Connor CJ, Zhang F, Galvagnion C, Galloway WR, Tan YS, Stokes JE, Rahman T, Verma C, Spring DR, Itzhaki LS. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Scientific Reports. 6: 23732. PMID 27046077 DOI: 10.1038/srep23732  0.96
2016 Wu Y, Olsen LB, Lau YH, Jensen CH, Rossmann M, Baker Y, Sore H, Collins S, Spring D. Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labeling. Chembiochem : a European Journal of Chemical Biology. PMID 26919579 DOI: 10.1002/cbic.201500648  0.96
2016 Salvaggio F, Hodgkinson JT, Carro L, Geddis SM, Galloway WRJD, Welch M, Spring DR. The synthesis of quinolone natural products from pseudonocardia sp European Journal of Organic Chemistry. 2016: 434-437. DOI: 10.1002/ejoc.201501400  0.96
2015 Alza E, Laraia L, Ibbeson BM, Collins S, Galloway WRJD, Stokes JE, Venkitaraman AR, Spring DR. Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction. Chemical Science. 6: 390-396. PMID 28966765 DOI: 10.1039/c4sc02547d  0.32
2015 Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angewandte Chemie (International Ed. in English). 54: 15410-3. PMID 26768531 DOI: 10.1002/anie.201508416  0.96
2015 Alanine TA, Galloway WR, Bartlett S, Ciardiello JJ, McGuire TM, Spring DR. Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. Organic & Biomolecular Chemistry. PMID 26632452 DOI: 10.1039/c5ob01784j  0.96
2015 Tan YS, Spring DR, Abell C, Verma CS. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. Journal of Chemical Theory and Computation. 11: 3199-3210. PMID 26575757 DOI: 10.1021/ct5010577  0.96
2015 Crousilles A, Maunders E, Bartlett S, Fan C, Ukor EF, Abdelhamid Y, Baker Y, Floto A, Spring DR, Welch M. Which microbial factors really are important in Pseudomonas aeruginosa infections? Future Microbiology. PMID 26515254 DOI: 10.2217/fmb.15.100  0.96
2015 Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions. Chemistry & Biology. 22: 689-703. PMID 26091166 DOI: 10.1016/j.chembiol.2015.04.019  0.96
2015 Scanes RJ, Grossmann O, Grossmann A, Spring DR. Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction. Organic Letters. 17: 2462-5. PMID 25915565 DOI: 10.1021/acs.orglett.5b00971  0.96
2015 Isidro-Llobet A, Hadje Georgiou K, Galloway WR, Giacomini E, Hansen MR, Méndez-Abt G, Tan YS, Carro L, Sore HF, Spring DR. A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds. Organic & Biomolecular Chemistry. 13: 4570-80. PMID 25778821 DOI: 10.1039/c5ob00371g  0.96
2015 Lau YH, Wu Y, de Andrade P, Galloway WR, Spring DR. A two-component 'double-click' approach to peptide stapling. Nature Protocols. 10: 585-94. PMID 25763835 DOI: 10.1038/nprot.2015.033  0.96
2015 Frei MS, Bilyard MK, Alanine TA, Galloway WR, Stokes JE, Spring DR. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis. Bioorganic & Medicinal Chemistry. 23: 2666-79. PMID 25614112 DOI: 10.1016/j.bmc.2014.11.037  0.96
2015 Lau YH, de Andrade P, Wu Y, Spring DR. Peptide stapling techniques based on different macrocyclisation chemistries. Chemical Society Reviews. 44: 91-102. PMID 25199043 DOI: 10.1039/c4cs00246f  0.96
2015 Alza E, Laraia L, Ibbeson BM, Collins S, Galloway WRJD, Stokes JE, Venkitaraman AR, Spring DR. Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction Chemical Science. 6: 390-396. DOI: 10.1039/c4sc02547d  0.96
2015 Sum TH, Sum TJ, Stokes JE, Galloway WRJD, Spring DR. Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha Tetrahedron. 71: 4557-4564. DOI: 10.1016/j.tet.2015.02.017  0.96
2015 Sams T, Baker Y, Hodgkinson J, Gross J, Spring D, Welch M. The Pseudomonas Quinolone Signal (PQS) Israel Journal of Chemistry. DOI: 10.1002/ijch.201400128  0.96
2014 Walsh Z, Jane?ek ER, Hodgkinson JT, Sedlmair J, Koutsioubas A, Spring DR, Welch M, Hirschmugl CJ, Toprakcioglu C, Nitschke JR, Jones M, Scherman OA. Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17743-8. PMID 25385610 DOI: 10.1073/pnas.1406037111  0.96
2014 Lau YH, de Andrade P, McKenzie GJ, Venkitaraman AR, Spring DR. Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides. Chembiochem : a European Journal of Chemical Biology. 15: 2680-3. PMID 25354189 DOI: 10.1002/cbic.201402374  0.96
2014 Grossmann A, Bartlett S, Janecek M, Hodgkinson JT, Spring DR. Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy. Angewandte Chemie (International Ed. in English). 53: 13093-7. PMID 25257387 DOI: 10.1002/anie.201406865  0.96
2014 Wachira SW, Omar S, Jacob JW, Wahome M, Alborn HT, Spring DR, Masiga DK, Torto B. Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae. Parasites & Vectors. 7: 312. PMID 24996560 DOI: 10.1186/1756-3305-7-312  0.96
2014 Zhang F, Spring DR. Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy. Chemical Society Reviews. 43: 6906-19. PMID 24983866 DOI: 10.1039/c4cs00137k  0.96
2014 Liu T, Liu X, Spring DR, Qian X, Cui J, Xu Z. Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe. Scientific Reports. 4: 5418. PMID 24957323 DOI: 10.1038/srep05418  0.96
2014 Tan YS, Spring DR, Abell C, Verma C. The use of chlorobenzene as a probe molecule in molecular dynamics simulations. Journal of Chemical Information and Modeling. 54: 1821-7. PMID 24910248 DOI: 10.1021/ci500215x  0.96
2014 Laraia L, Stokes J, Emery A, McKenzie GJ, Venkitaraman AR, Spring DR. High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics. Acs Medicinal Chemistry Letters. 5: 598-603. PMID 24900887 DOI: 10.1021/ml5000564  0.96
2014 Irvine KL, Gangloff M, Walsh CM, Spring DR, Gay NJ, Bryant CE. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2. Plos One. 9: e98776. PMID 24879320 DOI: 10.1371/journal.pone.0098776  0.96
2014 Lau YH, de Andrade P, Sköld N, McKenzie GJ, Venkitaraman AR, Verma C, Lane DP, Spring DR. Investigating peptide sequence variations for 'double-click' stapled p53 peptides. Organic & Biomolecular Chemistry. 12: 4074-7. PMID 24817343 DOI: 10.1039/c4ob00742e  0.96
2014 Koutsoukas A, Paricharak S, Galloway WR, Spring DR, Ijzerman AP, Glen RC, Marcus D, Bender A. How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space. Journal of Chemical Information and Modeling. 54: 230-42. PMID 24289493 DOI: 10.1021/ci400469u  0.96
2014 Lau YH, De Andrade P, Quah ST, Rossmann M, Laraia L, Sköld N, Sum TJ, Rowling PJE, Joseph TL, Verma C, Hyvönen M, Itzhaki LS, Venkitaraman AR, Brown CJ, Lane DP, ... Spring DR, et al. Functionalised staple linkages for modulating the cellular activity of stapled peptides Chemical Science. 5: 1804-1809. DOI: 10.1039/c4sc00045e  0.96
2014 Alanine TA, Galloway WRJD, McGuire TM, Spring DR. Concise synthesis of substituted quinolizin-4-ones by ring-closing metathesis European Journal of Organic Chemistry. 2014: 5767-5776. DOI: 10.1002/ejoc.201402648  0.96
2014 Galloway WRJD, Wilcke D, Nie F, Hadje-Georgiou K, Laraia L, Spring DR. Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems Concepts and Case Studies in Chemical Biology. 379-390. DOI: 10.1002/9783527687503.ch26  0.96
2013 Mestichelli P, Scott MJ, Galloway WR, Selwyn J, Parker JS, Spring DR. Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems. Organic Letters. 15: 5448-51. PMID 24134806 DOI: 10.1021/ol4025259  0.96
2013 Baker YR, Galloway WR, Hodgkinson JT, Spring DR. Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin. Molecules (Basel, Switzerland). 18: 11783-96. PMID 24071985 DOI: 10.3390/molecules181011783  0.96
2013 Beckmann HS, Nie F, Hagerman CE, Johansson H, Tan YS, Wilcke D, Spring DR. A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling. Nature Chemistry. 5: 861-7. PMID 24056343 DOI: 10.1038/nchem.1729  0.96
2013 O'Connell KM, Hodgkinson JT, Sore HF, Welch M, Salmond GP, Spring DR. Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials. Angewandte Chemie (International Ed. in English). 52: 10706-33. PMID 24038605 DOI: 10.1002/anie.201209979  0.96
2013 Bowden SD, Hale N, Chung JC, Hodgkinson JT, Spring DR, Welch M. Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing. Microbiology (Reading, England). 159: 2375-85. PMID 24025601 DOI: 10.1099/mic.0.070748-0  0.96
2013 Bowden SD, Eyres A, Chung JC, Monson RE, Thompson A, Salmond GP, Spring DR, Welch M. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp. Molecular Microbiology. 90: 457-71. PMID 23957692 DOI: 10.1111/mmi.12369  0.96
2013 Welch M, Hodgkinson JT, Gross J, Spring DR, Sams T. Ligand binding kinetics of the quorum sensing regulator PqsR. Biochemistry. 52: 4433-8. PMID 23713667 DOI: 10.1021/bi400315s  0.96
2013 Liu T, Xu Z, Spring DR, Cui J. A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells. Organic Letters. 15: 2310-3. PMID 23614763 DOI: 10.1021/ol400973v  0.96
2013 Laraia L, Spring DR. Chemical library screening approaches to aid the design of protein-protein inhibitors Understanding and Exploiting Protein-Protein Interactions as Drug Targets. 33-45. DOI: 10.4155/EBO.13.151  0.96
2013 Kenwright JL, Galloway WRJD, Wortmann L, Spring DR. Mild and efficient synthesis of benzo-fused seven- and eight-membered ring lactams: A convenient approach to biologically interesting chemotypes Synthetic Communications. 43: 1508-1516. DOI: 10.1080/00397911.2011.643439  0.96
2013 Postma TM, Galloway WRJD, Cougnon FBL, Panto? GD, Stokes JE, Spring DR. Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections Synlett. 24: 765-769. DOI: 10.1055/s-0032-1318407  0.96
2012 O'Connell KM, Díaz-Gavilán M, Galloway WR, Spring DR. Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds. Beilstein Journal of Organic Chemistry. 8: 850-60. PMID 23015833 DOI: 10.3762/bjoc.8.95  0.96
2012 Morkunas B, Galloway WR, Wright M, Ibbeson BM, Hodgkinson JT, O'Connell KM, Bartolucci N, Della Valle M, Welch M, Spring DR. Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics. Organic & Biomolecular Chemistry. 10: 8452-64. PMID 23014532 DOI: 10.1039/c2ob26501j  0.96
2012 Tan YS, ?led? P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 51: 10078-81. PMID 22961729 DOI: 10.1002/anie.201205676  0.96
2012 O'Connell KM, Beckmann HS, Laraia L, Horsley HT, Bender A, Venkitaraman AR, Spring DR. A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds. Organic & Biomolecular Chemistry. 10: 7545-51. PMID 22890306 DOI: 10.1039/c2ob26272j  0.96
2012 Galloway WR, Hodgkinson JT, Bowden S, Welch M, Spring DR. Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria. Trends in Microbiology. 20: 449-58. PMID 22771187 DOI: 10.1016/j.tim.2012.06.003  0.96
2012 Frye EC, O'Connor CJ, Twigg DG, Elbert B, Laraia L, Hulcoop DG, Venkitaraman AR, Spring DR. Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8774-9. PMID 22678946 DOI: 10.1002/chem.201200431  0.96
2012 Hodgkinson JT, Galloway WR, Welch M, Spring DR. Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs. Nature Protocols. 7: 1184-92. PMID 22635110 DOI: 10.1038/nprot.2012.054  0.96
2012 Lee JW, Carrascón V, Gallimore PJ, Fuller SJ, Björkegren A, Spring DR, Pope FD, Kalberer M. The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles. Physical Chemistry Chemical Physics : Pccp. 14: 8023-31. PMID 22532101 DOI: 10.1039/c2cp24094g  0.96
2012 Hodgkinson JT, Galloway WR, Wright M, Mati IK, Nicholson RL, Welch M, Spring DR. Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa. Organic & Biomolecular Chemistry. 10: 6032-44. PMID 22499353 DOI: 10.1039/c2ob25198a  0.96
2012 O' Connor CJ, Beckmann HS, Spring DR. Diversity-oriented synthesis: producing chemical tools for dissecting biology. Chemical Society Reviews. 41: 4444-56. PMID 22491328 DOI: 10.1039/c2cs35023h  0.96
2012 Xu Z, Liu X, Pan J, Spring DR. Coumarin-derived transformable fluorescent sensor for Zn2+. Chemical Communications (Cambridge, England). 48: 4764-6. PMID 22472965 DOI: 10.1039/c2cc30963g  0.96
2012 Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR. Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity. Organic & Biomolecular Chemistry. 10: 2590-3. PMID 22361895 DOI: 10.1039/c2ob25065a  0.96
2012 Zheng S, Aves SJ, Laraia L, Galloway WR, Pike KG, Wu W, Spring DR. A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 3193-8. PMID 22307955 DOI: 10.1002/chem.201103530  0.96
2012 Sore HF, Galloway WR, Spring DR. Palladium-catalysed cross-coupling of organosilicon reagents. Chemical Society Reviews. 41: 1845-66. PMID 22048071 DOI: 10.1039/c1cs15181a  0.96
2012 Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR. Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy Synlett. 290-294. DOI: 10.1055/s-0031-1290119  0.96
2012 Aves SJ, O'Connell KMG, Pike KG, Spring DR. Synthesis of highly substituted symmetrical 1,3-dienes via organocuprate oxidation Synlett. 298-300. DOI: 10.1055/s-0031-1290116  0.96
2011 Galloway WR, Spring DR. PNA to DNA to microarray decoding facilitates ligand discovery. Chemistry & Biology. 18: 1209-10. PMID 22035789 DOI: 10.1016/j.chembiol.2011.10.002  0.96
2011 Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure (London, England : 1993). 19: 1691-700. PMID 22000412 DOI: 10.1016/j.str.2011.09.017  0.96
2011 Boehner CM, Frye EC, O'Connell KM, Galloway WR, Sore HF, Dominguez PG, Norton D, Hulcoop DG, Owen M, Turner G, Crawford C, Horsley H, Spring DR. Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 13230-9. PMID 21990071 DOI: 10.1002/chem.201102285  0.96
2011 Ha DG, Merritt JH, Hampton TH, Hodgkinson JT, Janecek M, Spring DR, Welch M, O'Toole GA. 2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa. Journal of Bacteriology. 193: 6770-80. PMID 21965567 DOI: 10.1128/JB.05929-11  0.96
2011 Ramsay JP, Williamson NR, Spring DR, Salmond GP. A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium. Proceedings of the National Academy of Sciences of the United States of America. 108: 14932-7. PMID 21873216 DOI: 10.1073/pnas.1109169108  0.96
2011 Tavassoli A, Hamilton AD, Spring DR. Small molecules in biology. Chemical Society Reviews. 40: 4269-70. PMID 21720613 DOI: 10.1039/c1cs90028e  0.96
2011 O'Connor CJ, Laraia L, Spring DR. Chemical genetics. Chemical Society Reviews. 40: 4332-45. PMID 21562678 DOI: 10.1039/c1cs15053g  0.96
2011 Xu Z, Spring DR, Yoon J. Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene. Chemistry, An Asian Journal. 6: 2114-22. PMID 21506284 DOI: 10.1002/asia.201100120  0.96
2011 van der Horst E, Peironcely JE, van Westen GJ, van den Hoven OO, Galloway WR, Spring DR, Wegner JK, van Vlijmen HW, Ijzerman AP, Overington JP, Bender A. Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space. Current Topics in Medicinal Chemistry. 11: 1964-77. PMID 21470175 DOI: 10.2174/156802611796391230  0.96
2011 Poulter S, Carlton TM, Spring DR, Salmond GP. The Serratia LuxR family regulator CarR 39006 activates transcription independently of cognate quorum sensing signals. Molecular Microbiology. 80: 1120-31. PMID 21435033 DOI: 10.1111/j.1365-2958.2011.07634.x  0.96
2011 Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson JT, Galloway WR, Bender A, Welch M, Spring DR. Diversity-oriented synthesis of macrocyclic peptidomimetics. Proceedings of the National Academy of Sciences of the United States of America. 108: 6793-8. PMID 21383137 DOI: 10.1073/pnas.1015267108  0.96
2011 Shim JU, Patil SN, Hodgkinson JT, Bowden SD, Spring DR, Welch M, Huck WT, Hollfelder F, Abell C. Controlling the contents of microdroplets by exploiting the permeability of PDMS. Lab On a Chip. 11: 1132-7. PMID 21298160 DOI: 10.1039/c0lc00615g  0.96
2011 Kenwright JL, Galloway WR, Blackwell DT, Isidro-Llobet A, Hodgkinson J, Wortmann L, Bowden SD, Welch M, Spring DR. Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 2981-6. PMID 21290435 DOI: 10.1002/chem.201002093  0.96
2011 Huggins DJ, Venkitaraman AR, Spring DR. Rational methods for the selection of diverse screening compounds. Acs Chemical Biology. 6: 208-17. PMID 21261294 DOI: 10.1021/cb100420r  0.96
2011 Xu Z, Singh NJ, Kim SK, Spring DR, Kim KS, Yoon J. Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 1163-70. PMID 21243682 DOI: 10.1002/chem.201002105  0.96
2011 Galloway WR, Hodgkinson JT, Bowden SD, Welch M, Spring DR. Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chemical Reviews. 111: 28-67. PMID 21182299 DOI: 10.1021/cr100109t  0.96
2011 Hodgkinson JT, Galloway WR, Saraf S, Baxendale IR, Ley SV, Ladlow M, Welch M, Spring DR. Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues. Organic & Biomolecular Chemistry. 9: 57-61. PMID 20967360 DOI: 10.1039/c0ob00652a  0.96
2011 Sore HF, Boehner CM, Laraia L, Logoteta P, Prestinari C, Scott M, Williams K, Galloway WR, Spring DR. Vinyldisiloxanes: their synthesis, cross coupling and applications. Organic & Biomolecular Chemistry. 9: 504-15. PMID 20941422 DOI: 10.1039/c0ob00338g  0.96
2011 Gallimore PJ, Achakulwisut P, Pope FD, Davies JF, Spring DR, Kalberer M. Importance of relative humidity in the oxidative ageing of organic aerosols: Case study of the ozonolysis of maleic acid aerosol Atmospheric Chemistry and Physics. 11: 12181-12195. DOI: 10.5194/acp-11-12181-2011  0.96
2011 Blackwell DT, Galloway WRJD, Spring DR. Stereoselective synthesis of disubstituted butadienes via copper-mediated coupling of alkenyl silanes Synlett. 2140-2144. DOI: 10.1055/s-0030-1261150  0.96
2011 Lau YH, Spring DR. Efficient synthesis of Fmoc-protected azido amino acids Synlett. 1917-1919. DOI: 10.1055/s-0030-1260950  0.96
2011 Wyatt EE, Galloway WRJD, Spring DR. Regioselectivity in thermal rhodium(II)-catalysed Büchner-type reactions of substituted aryl halides: Studies towards the synthesis of halide-substituted cycloheptatrienes Synlett. 1449-1453. DOI: 10.1055/s-0030-1260562  0.96
2011 Hodgkinson JT, Galloway WRJD, Casoli M, Keane H, Su X, Salmond GPC, Welch M, Spring DR. Robust routes for the synthesis of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity Tetrahedron Letters. 52: 3291-3294. DOI: 10.1016/j.tetlet.2011.04.059  0.96
2010 Poulter S, Carlton TM, Su X, Spring DR, Salmond GP. Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules. Environmental Microbiology Reports. 2: 322-8. PMID 23766084 DOI: 10.1111/j.1758-2229.2010.00140.x  0.96
2010 Marsden DM, Nicholson RL, Skindersoe ME, Galloway WR, Sore HF, Givskov M, Salmond GP, Ladlow M, Welch M, Spring DR. Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening. Organic & Biomolecular Chemistry. 8: 5313-23. PMID 20886127 DOI: 10.1039/c0ob00300j  0.96
2010 Galloway WR, Isidro-Llobet A, Spring DR. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. Nature Communications. 1: 80. PMID 20865796 DOI: 10.1038/ncomms1081  0.96
2010 Xu Z, Zheng S, Yoon J, Spring DR. Discovery of a highly selective turn-on fluorescent probe for Ag+. The Analyst. 135: 2554-9. PMID 20830329 DOI: 10.1039/c0an00405g  0.96
2010 Hodgkinson J, Bowden SD, Galloway WR, Spring DR, Welch M. Structure-activity analysis of the Pseudomonas quinolone signal molecule. Journal of Bacteriology. 192: 3833-7. PMID 20494992 DOI: 10.1128/JB.00081-10  0.96
2010 Sore HF, Blackwell DT, Macdonald SJ, Spring DR. Diversity-oriented synthesis of disubstituted alkenes using masked silanols. Organic Letters. 12: 2806-9. PMID 20491504 DOI: 10.1021/ol100895d  0.96
2010 Xu Z, Yoon J, Spring DR. A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching. Chemical Communications (Cambridge, England). 46: 2563-5. PMID 20461870 DOI: 10.1039/c000441c  0.96
2010 Xu Z, Yoon J, Spring DR. Fluorescent chemosensors for Zn(2+). Chemical Society Reviews. 39: 1996-2006. PMID 20428518 DOI: 10.1039/b916287a  0.96
2010 Xu Z, Han SJ, Lee C, Yoon J, Spring DR. Development of off-on fluorescent probes for heavy and transition metal ions. Chemical Communications (Cambridge, England). 46: 1679-81. PMID 20177614 DOI: 10.1039/b924503k  0.96
2010 Díaz-Gavilán M, Galloway WR, O'Connell KM, Hodkingson JT, Spring DR. Diversity-oriented synthesis of bicyclic and tricyclic alkaloids. Chemical Communications (Cambridge, England). 46: 776-8. PMID 20087517 DOI: 10.1039/b917965h  0.96
2010 Xu Z, Baek KH, Kim HN, Cui J, Qian X, Spring DR, Shin I, Yoon J. Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor. Journal of the American Chemical Society. 132: 601-10. PMID 20000765 DOI: 10.1021/ja907334j  0.96
2010 Bryant CE, Spring DR, Gangloff M, Gay NJ. The molecular basis of the host response to lipopolysaccharide. Nature Reviews. Microbiology. 8: 8-14. PMID 19946286 DOI: 10.1038/nrmicro2266  0.96
2010 Aves SJ, Pike KG, Spring DR. Synthesis of highly substituted symmetrical 1,3-dienes via tandem carbocupration and organocuprate oxidation Synlett. 2839-2842. DOI: 10.1055/s-0030-1259024  0.96
2010 Boehner CM, Marsden DM, Sore HF, Norton D, Spring DR. High throughput 'catch-and-release' synthesis within spatially discrete gel arrays Tetrahedron Letters. 51: 5930-5932. DOI: 10.1016/j.tetlet.2010.09.024  0.96
2010 Xu Z, Pan J, Spring DR, Cui J, Yoon J. Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach Tetrahedron. 66: 1678-1683. DOI: 10.1016/j.tet.2010.01.008  0.96
2010 Shim JU, Patil SN, Hodgkinson JT, Bowden SD, Spring DR, Welch M, Huck WTS, Hollfelder F, Abell C. Induction of quorum sensing in microdroplets by transporting small molecule through PDMS 14th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2010, Microtas 2010. 1: 656-658.  0.96
2009 Galloway WR, Spring DR. Is synthesis the main hurdle for the generation of diversity in compound libraries for screening? Expert Opinion On Drug Discovery. 4: 467-72. PMID 23485081 DOI: 10.1517/17460440902916606  0.96
2009 Marsden DM, Nicholson RL, Ladlow M, Spring DR. 3D small-molecule microarrays. Chemical Communications (Cambridge, England). 7107-9. PMID 19920998 DOI: 10.1039/b913665g  0.96
2009 Galloway WR, Hodgkinson JT, Welch M, Spring DR. Mastering the chemical language of bacteria. Chemistry & Biology. 16: 913-4. PMID 19778715 DOI: 10.1016/j.chembiol.2009.09.006  0.96
2009 Galloway WR, Bender A, Welch M, Spring DR. The discovery of antibacterial agents using diversity-oriented synthesis. Chemical Communications (Cambridge, England). 2446-62. PMID 19532856 DOI: 10.1039/b816852k  0.96
2009 Kapadnis PB, Hall E, Ramstedt M, Galloway WR, Welch M, Spring DR. Towards quorum-quenching catalytic antibodies. Chemical Communications (Cambridge, England). 538-40. PMID 19283283 DOI: 10.1039/b819819e  0.96
2009 Sore HF, Boehner CM, MacDonald SJ, Norton D, Fox DJ, Spring DR. Fluoride-free cross coupling using vinyldisiloxanes. Organic & Biomolecular Chemistry. 7: 1068-72. PMID 19262923 DOI: 10.1039/b900852g  0.96
2009 Galloway WR, Diáz-Gavilán M, Isidro-Llobet A, Spring DR. Synthesis of unprecedented scaffold diversity. Angewandte Chemie (International Ed. in English). 48: 1194-6. PMID 19137520 DOI: 10.1002/anie.200805452  0.96
2009 Su X, Thomas GL, Galloway WRJD, Surry DS, Spandl RJ, Spring DR. Synthesis of biaryl-containing medium-ring systems by organocuprate oxidation: Applications in the total synthesis of ellagitannin natural products Synthesis. 3880-3896. DOI: 10.1055/s-0029-1218154  0.96
2009 Spandl RJ, Thomas GL, Diaz-Gavilan M, O'Connell KMG, Spring DR. An Introduction to Diversity-Oriented Synthesis Linker Strategies in Solid-Phase Organic Synthesis. 239-262. DOI: 10.1002/9780470749043.ch8  0.96
2008 Glansdorp FG, Spandl RJ, Swatton JE, Loiseleur O, Welch M, Spring DR. Using chemical probes to investigate the sub-inhibitory effects of azithromycin. Organic & Biomolecular Chemistry. 6: 4120-4. PMID 18972042 DOI: 10.1039/b813157k  0.96
2008 Wyatt EE, Galloway WR, Thomas GL, Welch M, Loiseleur O, Plowright AT, Spring DR. Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis. Chemical Communications (Cambridge, England). 4962-4. PMID 18931753 DOI: 10.1039/b812901k  0.96
2008 Robinson A, Thomas GL, Spandl RJ, Welch M, Spring DR. Gemmacin B: bringing diversity back into focus. Organic & Biomolecular Chemistry. 6: 2978-81. PMID 18688491 DOI: 10.1039/b809038f  0.96
2008 Spandl RJ, Rudyk H, Spring DR. Exploiting domino enyne metathesis mechanisms for skeletal diversity generation. Chemical Communications (Cambridge, England). 3001-3. PMID 18688328 DOI: 10.1039/b807278g  0.96
2008 Spring D. Editorial: the chemistry-biology interface. Chemical Society Reviews. 37: 1293. PMID 18568155 DOI: 10.1039/b808132h  0.96
2008 Spandl RJ, Díaz-Gavilán M, O'Connell KM, Thomas GL, Spring DR. Diversity-oriented synthesis. Chemical Record (New York, N.Y.). 8: 129-42. PMID 18563806 DOI: 10.1002/tcr.20144  0.96
2008 Su X, Surry DS, Spandl RJ, Spring DR. Total synthesis of sanguiin H-5. Organic Letters. 10: 2593-6. PMID 18505263 DOI: 10.1021/ol8009545  0.96
2008 Lee LY, Hupfield T, Nicholson RL, Hodgkinson JT, Su X, Thomas GL, Salmond GP, Welch M, Spring DR. 2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator. Molecular Biosystems. 4: 505-7. PMID 18493644 DOI: 10.1039/b801563e  0.96
2008 Spandl RJ, Bender A, Spring DR. Diversity-oriented synthesis; a spectrum of approaches and results. Organic & Biomolecular Chemistry. 6: 1149-58. PMID 18362950 DOI: 10.1039/b719372f  0.96
2008 Thomas GL, Spandl RJ, Glansdorp FG, Welch M, Bender A, Cockfield J, Lindsay JA, Bryant C, Brown DF, Loiseleur O, Rudyk H, Ladlow M, Spring DR. Anti-MRSA agent discovery using diversity-oriented synthesis. Angewandte Chemie (International Ed. in English). 47: 2808-12. PMID 18307176 DOI: 10.1002/anie.200705415  0.96
2008 Spandl RJ, Nicholson RL, Marsden DM, Hodgkinson JT, Su X, Thomas GL, Salmond GPC, Welch M, Spring DR. Synthesis of a biotin-labeled quorum-sensing molecule: Towards a general method for target identification Synlett. 2122-2126. DOI: 10.1055/s-2008-1077978  0.96
2007 Hodgkinson JT, Welch M, Spring DR. Learning the language of bacteria. Acs Chemical Biology. 2: 715-7. PMID 18030987 DOI: 10.1021/cb700227k  0.96
2007 Nicholson RL, Ladlow ML, Spring DR. Fluorous tagged small molecule microarrays. Chemical Communications (Cambridge, England). 3906-8. PMID 17896028 DOI: 10.1039/b712906h  0.96
2007 Worrall JA, Górna M, Pei XY, Spring DR, Nicholson RL, Luisi BF. Design and chance in the self-assembly of macromolecules. Biochemical Society Transactions. 35: 502-7. PMID 17511639 DOI: 10.1042/BST0350502  0.96
2007 Nicholson RL, Welch M, Ladlow M, Spring DR. Small-molecule screening: advances in microarraying and cell-imaging technologies. Acs Chemical Biology. 2: 24-30. PMID 17243780 DOI: 10.1021/cb600321j  0.96
2007 Nicholson RL, Ladlow ML, Spring DR. Fluorous tagged small molecule microarrays (Chemical Communications (2007) (3906) DOI: 10.1039/b712906h) Chemical Communications. 3966. DOI: 10.1039/b713867a  0.96
2006 Smith D, Wang JH, Swatton JE, Davenport P, Price B, Mikkelsen H, Stickland H, Nishikawa K, Gardiol N, Spring DR, Welch M. Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in gram-negative bacteria. Science Progress. 89: 167-211. PMID 17338438 DOI: 10.3184/003685006783238335  0.96
2006 Su X, Fox DJ, Blackwell DT, Tanaka K, Spring DR. Copper catalyzed oxidation of organozinc halides. Chemical Communications (Cambridge, England). 3883-5. PMID 17268658 DOI: 10.1039/b610218b  0.96
2006 Thomas GL, Wyatt EE, Spring DR. Enriching chemical space with diversity-oriented synthesis. Current Opinion in Drug Discovery & Development. 9: 700-12. PMID 17117681  0.96
2006 Wyatt EE, Fergus S, Galloway WR, Bender A, Fox DJ, Plowright AT, Jessiman AS, Welch M, Spring DR. Skeletal diversity construction via a branching synthetic strategy. Chemical Communications (Cambridge, England). 3296-8. PMID 16883415 DOI: 10.1039/b607710b  0.96
2006 Thomas GL, Böhner CM, Williams HE, Walsh CM, Ladlow M, Welch M, Bryant CE, Spring DR. Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages. Molecular Biosystems. 2: 132-7. PMID 16880931 DOI: 10.1039/b517248a  0.96
2006 Coulthurst SJ, Williamson NR, Harris AK, Spring DR, Salmond GP. Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities. Microbiology (Reading, England). 152: 1899-911. PMID 16804166 DOI: 10.1099/mic.0.28803-0  0.96
2006 Bender A, Fergus S, Galloway WR, Glansdorp FG, Marsden DM, Nicholson RL, Spandl RJ, Thomas GL, Wyatt EE, Glen RC, Spring DR. Diversity oriented synthesis: a challenge for synthetic chemists. Ernst Schering Research Foundation Workshop. 47-60. PMID 16708998  0.96
2006 Surry DS, Spring DR. The oxidation of organocuprates - An offbeat strategy for synthesis Chemical Society Reviews. 35: 218-225. DOI: 10.1039/b508391p  0.96
2005 Welch M, Mikkelsen H, Swatton JE, Smith D, Thomas GL, Glansdorp FG, Spring DR. Cell-cell communication in Gram-negative bacteria. Molecular Biosystems. 1: 196-202. PMID 16880983 DOI: 10.1039/b505796p  0.96
2005 Thomas GL, Böhner C, Ladlow M, Spring DR. Synthesis and utilization of functionalized polystyrene resins Tetrahedron. 61: 12153-12159. DOI: 10.1016/j.tet.2005.07.118  0.96
2004 Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America. 101: 16594-9. PMID 15539461 DOI: 10.1073/pnas.0407117101  0.96
2002 Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 124: 1354-63. PMID 11841305 DOI: 10.1021/ja017248o  0.96
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  0.96
1998 Baldwin JE, Claridge TDW, Culshaw AJ, Heupel FA, Lee V, Spring DR, Whitehead RC, Boughtflower RJ, Mutton IM, Upton RJ. Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis. Angewandte Chemie (International Ed. in English). 37: 2661-2663. PMID 29711622 DOI: 10.1002/(SICI)1521-3773(19981016)37:19<2661::AID-ANIE2661>3.0.CO;2-D  0.56
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