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Kevin R. Lynch - Publications

Affiliations: 
Pharmacology University of Virginia, Charlottesville, VA 
Area:
receptor pharmacology
Website:
http://innovation.virginia.edu/advisory/profile/krl2z

176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL. Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92. PMID 27190598 DOI: 10.1021/Acsmedchemlett.6B00002  0.44
2015 Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. The Journal of Pharmacology and Experimental Therapeutics. 355: 23-31. PMID 26243740 DOI: 10.1124/Jpet.115.225862  0.6
2015 Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L1245-52. PMID 25910934 DOI: 10.1152/Ajplung.00302.2014  0.6
2015 Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 25862200 DOI: 10.1016/J.Bmcl.2015.03.041  0.6
2015 Nakayama J, Raines TA, Lynch KR, Slack-Davis JK. Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1. Plos One. 10: e0120071. PMID 25769037 DOI: 10.1371/Journal.Pone.0120071  0.6
2015 Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. Journal of Medicinal Chemistry. 58: 1879-99. PMID 25643074 DOI: 10.1021/Jm501760D  0.6
2015 Santos WL, Lynch KR. Drugging sphingosine kinases. Acs Chemical Biology. 10: 225-33. PMID 25384187 DOI: 10.1021/Cb5008426  0.6
2015 Bajwa A, Rosin DL, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey GR, Stevens BK, Jobin K, Kenwood BM, Hoehn KL, Lynch KR, Okusa MD. Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury. Journal of the American Society of Nephrology : Jasn. 26: 908-25. PMID 25145931 DOI: 10.1681/Asn.2013121351  0.6
2014 Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood. 124: 1941-50. PMID 25075126 DOI: 10.1182/Blood-2014-01-543652  0.6
2014 Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism. 3: 124-34. PMID 24634818 DOI: 10.1016/J.Molmet.2013.11.003  0.6
2014 Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, ... ... Lynch KR, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Molecular Metabolism. 3: 114-23. PMID 24634817 DOI: 10.1016/J.Molmet.2013.11.005  0.6
2014 Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning Acta Biomaterialia. DOI: 10.1016/j.actbio.2014.08.007  0.6
2013 Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 13785-90. PMID 23918395 DOI: 10.1073/Pnas.1221309110  0.6
2013 Peyruchaud O, David M, Macdonald TL, Lynch KR. Lysophosphatidic Acid (LPA) Signaling and Bone Cancer Lysophospholipid Receptors: Signaling and Biochemistry. 627-640. DOI: 10.1002/9781118531426.ch29  0.6
2012 Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 189: 2584-96. PMID 22855711 DOI: 10.4049/Jimmunol.1200999  0.6
2012 Kharel Y, Raje M, Gao M, Gellett AM, Tomsig JL, Lynch KR, Santos WL. Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. The Biochemical Journal. 447: 149-57. PMID 22747486 DOI: 10.1042/Bj20120609  0.6
2012 Gellett AM, Kharel Y, Sunkara M, Morris AJ, Lynch KR. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. Biochemical and Biophysical Research Communications. 422: 758-63. PMID 22627129 DOI: 10.1016/J.Bbrc.2012.05.077  0.6
2012 Lynch KR. Building a better sphingosine kinase-1 inhibitor. The Biochemical Journal. 444: e1-2. PMID 22533672 DOI: 10.1042/Bj20120567  0.6
2012 Knott K, Kharel Y, Raje MR, Lynch KR, Santos WL. Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & Medicinal Chemistry Letters. 22: 6817-20. PMID 22321213 DOI: 10.1016/J.Bmcl.2012.01.050  0.6
2012 Raje MR, Knott K, Kharel Y, Bissel P, Lynch KR, Santos WL. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & Medicinal Chemistry. 20: 183-94. PMID 22137932 DOI: 10.1016/J.Bmc.2011.11.011  0.6
2012 Callihan P, Zitomer NC, Stoeling MV, Kennedy PC, Lynch KR, Riley RT, Hooks SB. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology. 62: 988-96. PMID 22016110 DOI: 10.1016/J.Neuropharm.2011.10.005  0.6
2012 Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury (Journal of Immunology (2012) 189 (2584-2596)) Journal of Immunology. 189: 4696. DOI: 10.4049/jimmunol.1290066  0.6
2011 East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A  0.6
2011 Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817  0.6
2011 Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552  0.6
2011 Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48. PMID 21495716 DOI: 10.1021/Jm2001053  0.6
2011 Awad AS, Rouse MD, Khutsishvili K, Huang L, Bolton WK, Lynch KR, Okusa MD. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney International. 79: 1090-8. PMID 21289599 DOI: 10.1038/Ki.2010.544  0.6
2011 Kharel Y, Mathews TP, Kennedy AJ, Houck JD, Macdonald TL, Lynch KR. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical Biochemistry. 411: 230-5. PMID 21216217 DOI: 10.1016/J.Ab.2011.01.003  0.6
2011 Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404  0.6
2010 Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 62: 579-87. PMID 21079037 DOI: 10.1124/Pr.110.003111  0.6
2010 East JE, Kennedy AJ, Tomsig JL, De Leon AR, Lynch KR, Macdonald TL. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & Medicinal Chemistry Letters. 20: 7132-6. PMID 20951039 DOI: 10.1016/J.Bmcl.2010.09.030  0.6
2010 Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, Kipnis J. Regulation of learning and memory by meningeal immunity: a key role for IL-4. The Journal of Experimental Medicine. 207: 1067-80. PMID 20439540 DOI: 10.1084/Jem.20091419  0.6
2010 Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 21: 955-65. PMID 20338995 DOI: 10.1681/Asn.2009060662  0.6
2010 Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H  0.6
2010 Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/J.Bmcl.2010.02.006  0.6
2010 Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Engineering. Part A. 16: 1801-9. PMID 20038198 DOI: 10.1089/Ten.Tea.2009.0539  0.6
2009 Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015  0.6
2009 Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. Journal of Neurochemistry. 110: 1191-202. PMID 19493165 DOI: 10.1111/J.1471-4159.2009.06202.X  0.6
2009 Tomsig JL, Snyder AH, Berdyshev EV, Skobeleva A, Mataya C, Natarajan V, Brindley DN, Lynch KR. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. The Biochemical Journal. 419: 611-8. PMID 19215222 DOI: 10.1042/Bj20081888  0.6
2009 Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis. 48: 801-9. PMID 19204929 DOI: 10.1002/Mc.20524  0.6
2009 Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Letters. 276: 171-9. PMID 19131156 DOI: 10.1016/J.Canlet.2008.11.025  0.6
2009 Jo SK, Bajwa A, Ye H, Vergis AL, Awad AS, Kharel Y, Lynch KR, Okusa MD. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney International. 75: 167-75. PMID 18971925 DOI: 10.1038/Ki.2008.400  0.6
2008 Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Molecular Cancer Research : McR. 6: 1649-56. PMID 18922980 DOI: 10.1158/1541-7786.Mcr-07-2048  0.6
2008 Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circulation Research. 103: 662-70. PMID 18703779 DOI: 10.1161/Circresaha.108.180778  0.6
2008 Lynch KR, Macdonald TL. Sphingosine 1-phosphate chemical biology. Biochimica Et Biophysica Acta. 1781: 508-12. PMID 18638568 DOI: 10.1016/J.Bbalip.2008.06.006  0.6
2008 Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392  0.6
2008 Rivera-Lopez CM, Tucker AL, Lynch KR. Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis. 11: 301-10. PMID 18504643 DOI: 10.1007/S10456-008-9113-5  0.6
2008 van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR, Moolenaar WH. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters. 266: 203-8. PMID 18378389 DOI: 10.1016/J.Canlet.2008.02.052  0.6
2008 Hughes JE, Srinivasan S, Lynch KR, Proia RL, Ferdek P, Hedrick CC. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circulation Research. 102: 950-8. PMID 18323526 DOI: 10.1161/Circresaha.107.170779  0.6
2008 Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney International. 73: 1220-30. PMID 18322542 DOI: 10.1038/Ki.2008.34  0.6
2008 Cui P, McCalmont WF, Tomsig JL, Lynch KR, Macdonald TL. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorganic & Medicinal Chemistry. 16: 2212-25. PMID 18082408 DOI: 10.1016/J.Bmc.2007.11.078  0.6
2008 Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC. Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes. 57: 484-93. PMID 18003758 DOI: 10.2337/Db07-0855  0.6
2007 Okusa MD, Lynch KR. Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug Discovery Today. Disease Mechanisms. 4: 55-59. PMID 19448841 DOI: 10.1016/J.Ddmec.2007.07.001  0.6
2007 Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172  0.6
2007 Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 1634-40. PMID 17257836 DOI: 10.1016/J.Bmcl.2006.12.114  0.6
2007 Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200  0.6
2007 Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 15: 663-77. PMID 17113298 DOI: 10.1016/J.Bmc.2006.10.060  0.6
2006 Awad AS, Ye H, Huang L, Li L, Foss FW, Macdonald TL, Lynch KR, Okusa MD. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology. Renal Physiology. 290: F1516-24. PMID 16403835 DOI: 10.1152/Ajprenal.00311.2005  0.6
2005 Foss FW, Clemens JJ, Davis MD, Snyder AH, Zigler MA, Lynch KR, Macdonald TL. Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4. PMID 16125386 DOI: 10.1016/J.Bmcl.2005.07.057  0.6
2005 Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S, Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of Biological Chemistry. 280: 36865-72. PMID 16093248 DOI: 10.1074/Jbc.M506293200  0.6
2005 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72. PMID 15982878 DOI: 10.1016/J.Bmcl.2005.05.097  0.6
2005 Lee S, Lynch KR. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). The Biochemical Journal. 391: 317-23. PMID 15926888 DOI: 10.1042/Bj20050043  0.6
2005 Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81. PMID 15761190 DOI: 10.1161/01.Atv.0000162171.30089.F6  0.6
2005 Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41. PMID 15590668 DOI: 10.1074/Jbc.M412356200  0.6
2004 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6. PMID 15341948 DOI: 10.1016/J.Bmcl.2004.07.030  0.6
2004 Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 4069-74. PMID 15225728 DOI: 10.1016/J.Bmcl.2004.05.023  0.6
2004 Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 14: 3473-6. PMID 15177455 DOI: 10.1016/J.Bmcl.2004.04.061  0.6
2004 Heasley BH, Jarosz R, Lynch KR, Macdonald TL. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 2735-40. PMID 15125924 DOI: 10.1016/J.Bmcl.2004.03.076  0.6
2004 Steinke JW, Crouse CD, Bradley D, Hise K, Lynch K, Kountakis SE, Borish L. Characterization of Interleukin-4-Stimulated Nasal Polyp Fibroblasts American Journal of Respiratory Cell and Molecular Biology. 30: 212-219. PMID 12920052 DOI: 10.1165/Rcmb.2003-0071Oc  0.6
2003 Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, Suhr KB, Milstien S, Spiegel S. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry. 42: 12181-91. PMID 14567679 DOI: 10.1021/Bi035051Y  0.6
2003 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4. PMID 14505636 DOI: 10.1016/S0960-894X(03)00812-6  0.6
2003 Okusa MD, Ye H, Huang L, Sigismund L, Macdonald T, Lynch KR. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. American Journal of Physiology. Renal Physiology. 285: F565-74. PMID 12770838 DOI: 10.1152/Ajprenal.00023.2003  0.6
2003 Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Brinkmann V, Nadler JL, Lynch KR. The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice. Clinical Immunology (Orlando, Fla.). 107: 30-5. PMID 12738247 DOI: 10.1016/S1521-6616(02)00054-2  0.6
2003 Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Novel human G-protein-coupled receptors. Biochemical and Biophysical Research Communications. 305: 67-71. PMID 12732197 DOI: 10.1016/S0006-291X(03)00709-5  0.6
2003 Hasegawa Y, Erickson JR, Goddard GJ, Yu S, Liu S, Cheng KW, Eder A, Bandoh K, Aoki J, Jarosz R, Schrier AD, Lynch KR, Mills GB, Fang X. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. The Journal of Biological Chemistry. 278: 11962-9. PMID 12554733 DOI: 10.1074/Jbc.M209168200  0.6
2002 Brinkmann V, Lynch KR. Transplantation Current Opinion in Immunology. 14: 559-561. PMID 12183153 DOI: 10.1016/S0952-7915(02)00390-4  0.6
2002 Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochimica Et Biophysica Acta. 1582: 289-94. PMID 12069840 DOI: 10.1016/S1388-1981(02)00183-X  0.6
2002 Lynch KR. Lysophospholipid receptor nomenclature. Biochimica Et Biophysica Acta. 1582: 70-1. PMID 12069811 DOI: 10.1016/S1388-1981(02)00138-5  0.6
2002 Takafuji VA, Evans A, Lynch KR, Roche JK. PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 66: 71-81. PMID 12051958 DOI: 10.1054/Plef.2001.0299  0.6
2002 Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 54: 265-9. PMID 12037142 DOI: 10.1124/Pr.54.2.265  0.6
2002 Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemistry. 277: 21453-7. PMID 11967257 DOI: 10.1074/Jbc.C200176200  0.6
2001 Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, Lynch KR. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Molecular Pharmacology. 60: 1173-80. PMID 11723223 DOI: 10.1124/Mol.60.6.1173  0.6
2001 Lee DK, George SR, Evans JF, Lynch KR, O'Dowd BF. Orphan G protein-coupled receptors in the CNS. Current Opinion in Pharmacology. 1: 31-9. PMID 11712532 DOI: 10.1016/S1471-4892(01)00003-0  0.6
2001 Im DS, Clemens J, Macdonald TL, Lynch KR. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60. PMID 11705398 DOI: 10.1021/Bi011606I  0.6
2001 Takafuji V, Lublin D, Lynch K, Roche JK. Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis Histochemistry and Cell Biology. 116: 171-181. PMID 11685545 DOI: 10.1007/S004180100287  0.6
2001 Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene. 275: 83-91. PMID 11574155 DOI: 10.1016/S0378-1119(01)00651-5  0.6
2001 Lynch KR, Macdonald TL. Structure activity relationships of lysophospholipid mediators. Prostaglandins & Other Lipid Mediators. 64: 33-45. PMID 11324706 DOI: 10.1016/S0090-6980(01)00106-X  0.44
2001 Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. The Journal of Cell Biology. 153: 429-34. PMID 11309421 DOI: 10.1083/Jcb.153.2.429  0.6
2001 Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101  0.6
2001 Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Molecular Pharmacology. 59: 427-33. PMID 11179435 DOI: 10.1124/Mol.59.3.427  0.6
2001 Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Research. Molecular Brain Research. 86: 13-22. PMID 11165367 DOI: 10.1016/S0169-328X(00)00242-4  0.6
2001 Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. The Journal of Biological Chemistry. 276: 4611-21. PMID 11042183 DOI: 10.1074/Jbc.M007782200  0.6
2000 Im DS, Ungar AR, Lynch KR. Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. Biochemical and Biophysical Research Communications. 279: 139-43. PMID 11112429 DOI: 10.1006/Bbrc.2000.3933  0.6
2000 Lynch K, Fernandez G, Pappalardo A, Peluso JJ. Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase Cδ-dependent pathway Endocrinology. 141: 4209-4217. PMID 11089555  0.6
2000 Takafuji V, Cosme R, Lublin D, Lynch K, Roche JK. Prostanoid receptors in intestinal epithelium: Selective expression, function, and change with inflammation Prostaglandins Leukotrienes and Essential Fatty Acids. 63: 223-235. PMID 11049698 DOI: 10.1016/S0016-5085(00)85381-0  0.6
2000 Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, ... ... Lynch KR, et al. Identification of receptors for neuromedin U and its role in feeding. Nature. 406: 70-4. PMID 10894543 DOI: 10.1038/35017610  0.6
2000 Cosme R, Lublin D, Takafuji V, Lynch K, Roche JK. Prostanoids in human colonic mucosa: Effects of inflammation on PGE2 receptor expression Human Immunology. 61: 684-696. PMID 10880739 DOI: 10.1016/S0016-5085(00)85326-3  0.6
2000 Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Lynch KR, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/Jbc.M003490200  0.6
2000 Goetzl EJ, Lynch KR. Preface: the omnific lysophospholipid growth factors. Annals of the New York Academy of Sciences. 905: xi-xiv. PMID 10818435 DOI: 10.1111/J.1749-6632.2000.Tb06531.X  0.6
2000 Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. The Journal of Biological Chemistry. 275: 14281-6. PMID 10799507 DOI: 10.1074/Jbc.275.19.14281  0.6
2000 Im DS, Heise CE, Harding MA, George SR, O'Dowd BF, Theodorescu D, Lynch KR. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Molecular Pharmacology. 57: 753-9. PMID 10727522 DOI: 10.1124/Mol.57.4.753  0.6
2000 Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. Cloning and characterization of additional members of the G protein-coupled receptor family. Biochimica Et Biophysica Acta. 1490: 311-23. PMID 10684976 DOI: 10.1016/S0167-4781(99)00241-9  0.6
2000 Goetzl EJ, Lynch KR. Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases by the New York Academy of Sciences, New York, NY, USA, 25-28 June 1999: Preface: The omnific lysophospholipid growth factors Annals of the New York Academy of Sciences. 905: xi-xiv.  0.6
1999 Lynch KR, Im DS. Life on the edg. Trends in Pharmacological Sciences. 20: 473-5. PMID 10603487 DOI: 10.1016/S0165-6147(99)01401-7  0.6
1999 Marchese A, George SR, Kolakowski LF, Lynch KR, O'Dowd BF. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends in Pharmacological Sciences. 20: 370-5. PMID 10462760 DOI: 10.1016/S0165-6147(99)01366-8  0.6
1999 Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658  0.6
1999 Retief JD, Lynch KR, Pearson WR. Panning for genes--A visual strategy for identifying novel gene orthologs and paralogs. Genome Research. 9: 373-82. PMID 10207159 DOI: 10.1101/Gr.9.4.373  0.6
1999 Hopper DW, Ragan SP, Hooks SB, Lynch KR, Macdonald TL. Structure--activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. Journal of Medicinal Chemistry. 42: 963-70. PMID 10090779 DOI: 10.1021/Jm970809V  0.6
1999 Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. Discovery of three novel orphan G-protein-coupled receptors. Genomics. 56: 12-21. PMID 10036181 DOI: 10.1006/Geno.1998.5655  0.6
1999 Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. Brain Research. Molecular Brain Research. 64: 193-8. PMID 9931487 DOI: 10.1016/S0169-328X(98)00277-0  0.6
1999 Im DS, Hooks SB, Lynch KR. Molecular pharmacology of lipid phosphoric acid receptors Proceedings of the Western Pharmacology Society. 42: 144.  0.6
1998 Hooks SB, Ragan SP, Lynch KR. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. Febs Letters. 427: 188-92. PMID 9607309 DOI: 10.1016/S0014-5793(98)00421-9  0.6
1998 Lee A, Wissekerke AE, Rosin DL, Lynch KR. Localization of alpha2C-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system. Neuroscience. 84: 1085-96. PMID 9578397 DOI: 10.1016/S0306-4522(97)00578-2  0.6
1998 O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR. Discovery of three novel G-protein-coupled receptor genes. Genomics. 47: 310-3. PMID 9479505 DOI: 10.1006/Geno.1998.5095  0.6
1998 Hooks SB, Ragan SP, Hopper DW, Hönemann CW, Durieux ME, Macdonald TL, Lynch KR. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Molecular Pharmacology. 53: 188-94. PMID 9463475 DOI: 10.1124/Mol.53.2.188  0.6
1997 Lynch KR, Hopper DW, Carlisle SJ, Catalano JG, Zhang M, MacDonald TL. Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety. Molecular Pharmacology. 52: 75-81. PMID 9224815 DOI: 10.1124/Mol.52.1.75  0.6
1997 O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene. 187: 75-81. PMID 9073069 DOI: 10.1016/S0378-1119(96)00722-6  0.6
1997 Jung BP, Nguyen T, Kolakowski LF, Lynch KR, Heng HHQ, George SR, O'Dowd BF. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1 Biochemical and Biophysical Research Communications. 230: 69-72. PMID 9020062 DOI: 10.1006/Bbrc.1996.5828  0.6
1997 Kolakqwsk LF, Casares J, Marchese A, Johnson MP, Nguyen T, Lynch KR, George SR, O'Dowd B. Discovery, cloning, and characterization of a novel human G protein-coupled receptor genes Faseb Journal. 11: A1339.  0.6
1996 Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HHQ, George SR, O'Dowd BF. Characterization of a human gene related to genes encoding somatostatin receptors Febs Letters. 398: 253-258. PMID 8977118 DOI: 10.1016/S0014-5793(96)01160-X  0.6
1996 D'Angelo DD, Terasawa T, Carlisle SJ, Dorn GW, Lynch KR. Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP. Prostaglandins. 52: 303-16. PMID 8936585 DOI: 10.1016/S0090-6980(96)00091-3  0.6
1996 Graham RM, Neubig R, Lynch KR. alpha 2-Adrenoceptors take centre stage at Nashville meeting. Trends in Pharmacological Sciences. 17: 90-4. PMID 8936342 DOI: 10.1016/0165-6147(96)30004-7  0.6
1996 Rosin DL, Talley EM, Lee A, Stornetta RL, Gaylinn BD, Guyenet PG, Lynch KR. Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. The Journal of Comparative Neurology. 372: 135-65. PMID 8841925 DOI: 10.1002/(Sici)1096-9861(19960812)372:1<135::Aid-Cne9>3.0.Co;2-4  0.6
1996 Talley EM, Rosin DL, Lee A, Guyenet PG, Lynch KR. Distribution of alpha 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. The Journal of Comparative Neurology. 372: 111-34. PMID 8841924 DOI: 10.1002/(SICI)1096-9861(19960812)372:1<111::AID-CNE8>3.0.CO;2-6  0.6
1996 O'Dowd BF, Nguyen T, Lynch KR, Kolakowski LF, Thompson M, Cheng R, Marchese A, Ng G, Heng HH, George SR. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. Febs Letters. 394: 325-9. PMID 8830667 DOI: 10.1016/0014-5793(96)00901-5  0.6
1995 Lee A, Talley E, Rosin DL, Lynch KR. Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells. Neuroendocrinology. 62: 215-25. PMID 8538858 DOI: 10.1159/000127007  0.6
1995 Stornetta RL, Huangfu D, Rosin DL, Lynch KR, Guyenet PG. Alpha-2 adrenergic receptors. Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine. Annals of the New York Academy of Sciences. 763: 541-51. PMID 7677372 DOI: 10.1111/J.1749-6632.1995.Tb32448.X  0.6
1995 Mnich SJ, Veenhuizen AW, Monahan JB, Sheehan KC, Lynch KR, Isakson PC, Portanova JP. Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2. Journal of Immunology (Baltimore, Md. : 1950). 155: 4437-44. PMID 7594605  0.6
1995 Lynch KR. Preparation and characterization of antibodies directed against G-protein-coupled receptors Pharmacology Communications. 6: 147-153.  0.6
1994 Durieux ME, Salafranca MN, Lynch KR. Trypsin induces Ca2+-activated Cl- currents in X. laevis oocytes Febs Letters. 337: 235-238. PMID 8293805 DOI: 10.1016/0014-5793(94)80198-3  0.6
1994 Harrison JK, Barber CM, Lynch KR. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors Neuroscience Letters. 169: 85-89. PMID 8047298 DOI: 10.1016/0304-3940(94)90362-X  0.6
1994 Tucker AL, Robeva AS, Taylor HE, Holeton D, Bockner M, Lynch KR, Linden J. A1 adenosine receptors: Two amino acids are responsible for species differences in ligand recognition Journal of Biological Chemistry. 269: 27900-27906. PMID 7961722  0.6
1994 Okusa MD, Lynch KR, Rosin DL, Huang L, Wei YY. Apical membrane and intracellular distribution of endogenous α2A-adrenergic receptors in MDCK cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267: F347-F353. PMID 7916533 DOI: 10.1152/Ajprenal.1994.267.3.F347  0.6
1994 Guyenet PG, Stornetta RL, Riley T, Norton FR, Rosin DL, Lynch KR. Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Research. 638: 285-94. PMID 7911062 DOI: 10.1016/0006-8993(94)90661-0  0.6
1994 Lynch KR, Harrison JK, Pearson WR. Classification of Adrenergic Receptor Subtypes: Molecular Biologic Approaches Neuroprotocols. 4: 14-19. DOI: 10.1006/Ncmn.1994.1003  0.6
1994 Okusa MD, Lynch KR, Rosin DL, Huang Liping, Wei Yuan Yuan. Apical membrane and intracellular distribution of endogenous alpha2A-adrenergic receptors in MDCK cells Am.J.Physiol.. 267: F347-F353.  0.6
1993 Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW. Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2 Molecular and Cellular Biology. 13: 4539-4548. PMID 8393135 DOI: 10.1128/Mcb.13.8.4539  0.6
1993 Harrison JK, Barber CM, Lynch KR. Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver Febs Letters. 318: 17-22. PMID 8382168 DOI: 10.1016/0014-5793(93)81318-T  0.6
1993 Wu J, Harrison JK, Vincent LA, Haystead C, Haystead TAJ, Michel H, Hunt DF, Lynch KR, Sturgill TW. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase Proceedings of the National Academy of Sciences of the United States of America. 90: 173-177. PMID 8380494 DOI: 10.1073/Pnas.90.1.173  0.6
1993 Durieux ME, Lynch KR. Signalling properties of lysophosphatidic acid Trends in Pharmacological Sciences. 14: 249-254. PMID 8372406 DOI: 10.1016/0165-6147(93)90021-B  0.6
1993 Rosin DL, Zeng D, Stornetta RL, Norton FR, Riley T, Okusa MD, Guyenet PG, Lynch KR. Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience. 56: 139-55. PMID 7901804 DOI: 10.1016/0306-4522(93)90569-2  0.6
1993 Durieux ME, Carlisle SJ, Salafranca MN, Lynch KR. Responses to sphingosine-1-phosphate in X. laevis oocytes: Similarities with lysophosphatidic acid signaling American Journal of Physiology - Cell Physiology. 264: C1360-C1364. PMID 7684565 DOI: 10.1152/Ajpcell.1993.264.5.C1360  0.6
1993 Gomez RA, Norling LL, Wilfong N, Isakson P, Lynch KR, Hock R, Quesenberry P. Leukocytes synthesize angiotensinogen Hypertension. 21: 470-475. PMID 7681424 DOI: 10.1161/01.Hyp.21.4.470  0.6
1993 Gaylinn BD, Harrison JK, Zysk JR, Lyons CE, Lynch KR, Thorner MO. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone Molecular Endocrinology. 7: 77-84. PMID 7680413 DOI: 10.1210/Mend.7.1.7680413  0.6
1993 Sessa WC, Barber CM, Lynch KR. Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein Circulation Research. 72: 921-924. PMID 7680289 DOI: 10.1161/01.Res.72.4.921  0.6
1992 Tucker AL, Linden J, Robeva AS, D'Angelo DD, Lynch KR. Cloning and expression of a bovine adenosine A1 receptor cDNA. Febs Letters. 297: 107-11. PMID 1551415 DOI: 10.1016/0014-5793(92)80338-H  0.6
1992 Durieux ME, Salafranca MN, Lynch KR, Moorman JR. Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes. The American Journal of Physiology. 263: C896-900. PMID 1415674 DOI: 10.1152/Ajpcell.1992.263.4.C896  0.6
1992 Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, Peach MJ. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. The Journal of Biological Chemistry. 267: 15274-6. PMID 1379225  0.6
1991 Harrison JK, Pearson WR, Lynch KR. Molecular characterization of α1- and α2-adrenoceptors Trends in Pharmacological Sciences. 12: 62-67. PMID 2024290 DOI: 10.1016/0165-6147(91)90499-I  0.6
1991 Lynch KR, Peach MJ. Molecular biology of angiotensinogen Hypertension. 17: 263-269. PMID 1999356 DOI: 10.1161/01.Hyp.17.3.263  0.6
1991 Linden J, Tucker AL, Lynch KR. Molecular cloning of adenosine A1 and A2 receptors Trends in Pharmacological Sciences. 12: 326-328. PMID 1949201 DOI: 10.1016/0165-6147(91)90589-K  0.6
1991 Menard J, El Amrani AIK, Savoie F, Bouhnik J, Lynch KR, Peach MJ. Angiotensinogen: An attractive and underrated participant in hypertension and inflammation Hypertension. 18: 705-707. PMID 1937670  0.6
1991 Harrison JK, D'Angelo DD, Zeng DW, Lynch KR. Pharmacological characterization of rat alpha 2-adrenergic receptors. Molecular Pharmacology. 40: 407-12. PMID 1654514  0.6
1991 Zeng D, Lynch KR. Distribution of α2-adrenergic receptor mRNAs in the rat CNS Molecular Brain Research. 10: 219-225. PMID 1653390 DOI: 10.1016/0169-328X(91)90064-5  0.6
1990 Saye J, Lynch KR, Peach MJ. Changes in angiotensinogen messenger RNA in differentiating 3T3-F442A adipocytes Hypertension. 15: 867-871. PMID 2351437 DOI: 10.1161/01.Hyp.15.6.867  0.6
1990 Gomez RA, Chevalier RL, Everett AD, Elwood JP, Peach MJ, Lynch KR, Carey RM. Recruitment of renin gene-expressing cells in adult rat kidneys American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259: F660-F665. PMID 2221104 DOI: 10.1152/Ajprenal.1990.259.4.F660  0.6
1990 Zeng DW, Harrison JK, D'Angelo DD, Barber CM, Tucker AL, Lu ZH, Lynch KR. Molecular characterization of a rat alpha 2B-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 3102-6. PMID 2158103 DOI: 10.1073/Pnas.87.8.3102  0.6
1990 Ross PC, Figler RA, Corjay MH, Barber CM, Adam N, Harcus DR, Lynch KR. RTA, a candidate G protein-coupled receptor: Cloning, sequencing, and tissue distribution Proceedings of the National Academy of Sciences of the United States of America. 87: 3052-3056. PMID 2109324 DOI: 10.1073/Pnas.87.8.3052  0.6
1989 Simpson L, McNiece I, Newberg M, Schetz J, Lynch KR, Quesenberry P, Isakson PC. Detection and characterization of a B cell stimulatory factor (BSF-TC) derived from a bone marrow stromal cell line Journal of Immunology. 142: 3894-3900. PMID 2785568  0.6
1989 Corjay MH, Thompson MM, Lynch KR, Owens GK. Differential effect of platelet-derived growth factor- versus serum-induced growth on smooth muscle α-actin and nonmuscle β-actin mRNA expression in cultured rat aortic smooth muscle cells Journal of Biological Chemistry. 264: 10501-10506. PMID 2732233  0.6
1989 Gomez RA, Lynch KR, Sturgill BC, Elwood JP, Chevalier RL, Carey RM, Peach MJ. Distribution of renin mRNA and its protein in the developing kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 257: 26/5. PMID 2686465 DOI: 10.1152/Ajprenal.1989.257.5.F850  0.6
1989 Ben-Ari ET, Lynch KR, Garrison JC. Glucocorticoids induce the accumulation of novel angiotensinogen gene transcripts Journal of Biological Chemistry. 264: 13074-13079. PMID 2546946  0.6
1989 Saye JA, Cassis LA, Sturgill TW, Lynch KR, Peach MJ. Angiotensinogen gene expression in 3T3-L1 cells American Journal of Physiology - Cell Physiology. 256: 25/2. PMID 2465693 DOI: 10.1152/Ajpcell.1989.256.2.C448  0.6
1988 Cassis LA, Lynch KR, Peach MJ. Localization of angiotensinogen messenger RNA in rat aorta Circulation Research. 62: 1259-1262. PMID 3383369 DOI: 10.1161/01.Res.62.6.1259  0.6
1988 Gomez RA, Lynch KR, Chevalier RL, Wilfong N, Everett A, Carey RM, Peach MJ. Renin and angiotensinogen gene expression in maturing rat kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 254: 23/4. PMID 3281475 DOI: 10.1152/Ajprenal.1988.254.4.F582  0.6
1988 Purkerson JM, Newberg M, Wise G, Lynch KR, Isakson PC. Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells Journal of Experimental Medicine. 168: 1175-1180. PMID 3262706 DOI: 10.1084/Jem.168.3.1175  0.6
1988 Stornetta RL, Hawelu-Johnson CL, Guyenet PG, Lynch KR. Astrocytes synthesize angiotensinogen in brain. Science (New York, N.Y.). 242: 1444-6. PMID 3201232 DOI: 10.1126/Science.3201232  0.6
1988 Gomez RA, Cassis L, Lynch KR, Chevalier RL, Wilfong N, Carey RM, Peach MJ. Fetal expression of the angiotensinogen gene Endocrinology. 123: 2298-2302. PMID 3168925 DOI: 10.1210/Endo-123-5-2298  0.6
1988 Hamman HC, Gaffey LC, Lynch KR, Creutz CE. Cloning and characterization of a cDNA encoding bovine endonexin (chromobindin 4). Biochemical and Biophysical Research Communications. 156: 660-7. PMID 2847715 DOI: 10.1016/S0006-291X(88)80893-3  0.6
1988 Gomez RA, Lynch KR, Chevalier RL, Everett AD, Johns DW, Wilfong N, Peach MJ, Carey RM. Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 254: 23/6. PMID 2837909 DOI: 10.1152/Ajprenal.1988.254.6.F900  0.6
1987 Fatigati V, Washington JM, Lynch KR, Peach MJ, Miller ED. Presence of angiotensinogen messenger RNA in various cultured cell lines Hypertension. 9: III-25-III-30. PMID 3596787 DOI: 10.1161/01.Hyp.9.6_Pt_2.Iii25  0.6
1987 Harrison JR, Lynch KR, Sando JJ. Phorbol esters induce interleukin 2 mRNA in sensitive but not in resistant EL4 cells Journal of Biological Chemistry. 262: 234-238. PMID 3491822  0.6
1987 Lynch KR, Hawelu-Johnson CL, Guyenet PG. Localization of brain angiotensinogen mRNA by hybridization histochemistry. Brain Research. 388: 149-58. PMID 3476177 DOI: 10.1016/0169-328X(87)90008-8  0.6
1987 Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR. Molecular cloning of rat renin cDNA and its gene Proceedings of the National Academy of Sciences of the United States of America. 84: 5605-5609. PMID 3039496 DOI: 10.1073/Pnas.84.16.5605  0.6
1987 Johns DW, Carey RM, Ariel Gomez R, Lynch K, Inagami T, Saye J, Geary K, Farnsworth DE, Peach MJ. Isolation of renin-rich rat kidney cells Hypertension. 10: 488-496. PMID 2444536 DOI: 10.1161/01.Hyp.10.5.488  0.6
1986 Lynch KR, Simnad VI, Ben-Ari ET, Garrison JC. Localization of preangiotensinogen messenger RNA sequences in the rat brain Hypertension. 8: 540-543. PMID 3710560  0.6
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