Kevin R. Lynch - Publications

Affiliations: 
Pharmacology University of Virginia, Charlottesville, VA 
Area:
receptor pharmacology
Website:
http://innovation.virginia.edu/advisory/profile/krl2z

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Year Citation  Score
2023 Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry. PMID 37010497 DOI: 10.1021/acs.jmedchem.3c00149  0.352
2022 Pashikanti S, Foster DJ, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. Acs Bio & Med Chem Au. 2: 469-489. PMID 36281302 DOI: 10.1021/acsbiomedchemau.2c00017  0.352
2022 Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry. PMID 35609189 DOI: 10.1021/acs.jmedchem.1c02171  0.307
2020 Kharel Y, Huang T, Salamon A, Harris T, Santos WL, Lynch KR. Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal. PMID 32065229 DOI: 10.1042/Bcj20190730  0.386
2020 Sibley CD, Morris EA, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Journal of Medicinal Chemistry. PMID 31895563 DOI: 10.1021/Acs.Jmedchem.9B01508  0.399
2018 Kharel Y, Agah S, Huang T, Mendelson AJ, Eletu OT, Barkey-Bircann P, Gesualdi J, Smith JS, Santos WL, Lynch KR. Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. Plos One. 13: e0192179. PMID 29672528 DOI: 10.1371/Journal.Pone.0192179  0.331
2017 Adamiak M, Chelvarajan L, Lynch KR, Santos WL, Abdel-Latif A, Ratajczak MZ. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 8: 65588-65600. PMID 29029455 DOI: 10.18632/Oncotarget.19514  0.372
2017 Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and In Vivo Activity. Journal of Medicinal Chemistry. PMID 28406646 DOI: 10.1021/Acs.Jmedchem.7B00233  0.433
2016 Lynch KR, Thorpe SB, Santos WL. Sphingosine kinase inhibitors: a review of patent literature (2006-2015). Expert Opinion On Therapeutic Patents. PMID 27539678 DOI: 10.1080/13543776.2016.1226282  0.354
2016 Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL. Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92. PMID 27190598 DOI: 10.1021/Acsmedchemlett.6B00002  0.37
2016 Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL. Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors. Acs Medicinal Chemistry Letters. 7: 229-34. PMID 26985306 DOI: 10.1021/Acsmedchemlett.5B00304  0.37
2016 Perry HM, Huang L, Ye H, Liu C, Sung SJ, Lynch KR, Rosin DL, Bajwa A, Okusa MD. Endothelial Sphingosine 1‑Phosphate Receptor‑1 Mediates Protection and Recovery from Acute Kidney Injury. Journal of the American Society of Nephrology : Jasn. PMID 26961351 DOI: 10.1681/Asn.2015080922  0.357
2015 Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. The Journal of Pharmacology and Experimental Therapeutics. 355: 23-31. PMID 26243740 DOI: 10.1124/Jpet.115.225862  0.38
2015 Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L1245-52. PMID 25910934 DOI: 10.1152/Ajplung.00302.2014  0.37
2015 Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 25862200 DOI: 10.1016/J.Bmcl.2015.03.041  0.392
2015 Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. Journal of Medicinal Chemistry. 58: 1879-99. PMID 25643074 DOI: 10.1021/Jm501760D  0.444
2015 Santos WL, Lynch KR. Drugging sphingosine kinases. Acs Chemical Biology. 10: 225-33. PMID 25384187 DOI: 10.1021/Cb5008426  0.376
2015 Bajwa A, Rosin DL, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey GR, Stevens BK, Jobin K, Kenwood BM, Hoehn KL, Lynch KR, Okusa MD. Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury. Journal of the American Society of Nephrology : Jasn. 26: 908-25. PMID 25145931 DOI: 10.1681/Asn.2013121351  0.541
2014 Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomaterialia. 10: 4704-14. PMID 25128750 DOI: 10.1016/J.Actbio.2014.08.007  0.4
2014 Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood. 124: 1941-50. PMID 25075126 DOI: 10.1182/Blood-2014-01-543652  0.418
2013 Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 13785-90. PMID 23918395 DOI: 10.1073/Pnas.1221309110  0.363
2013 Raines TA, Lynch KR, Slack-Davis JK. Abstract 2805: LPA-dependent regulation of VCAM-1 in the ovarian cancer metastatic microenvironment and its impact on mesothelial invasion. Cancer Research. 73: 2805-2805. DOI: 10.1158/1538-7445.Am2013-2805  0.34
2012 Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 189: 2584-96. PMID 22855711 DOI: 10.4049/Jimmunol.1200999  0.344
2012 Kharel Y, Raje M, Gao M, Gellett AM, Tomsig JL, Lynch KR, Santos WL. Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. The Biochemical Journal. 447: 149-57. PMID 22747486 DOI: 10.1042/Bj20120609  0.789
2012 Gellett AM, Kharel Y, Sunkara M, Morris AJ, Lynch KR. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. Biochemical and Biophysical Research Communications. 422: 758-63. PMID 22627129 DOI: 10.1016/J.Bbrc.2012.05.077  0.786
2012 Lynch KR. Building a better sphingosine kinase-1 inhibitor. The Biochemical Journal. 444: e1-2. PMID 22533672 DOI: 10.1042/Bj20120567  0.428
2012 Knott K, Kharel Y, Raje MR, Lynch KR, Santos WL. Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & Medicinal Chemistry Letters. 22: 6817-20. PMID 22321213 DOI: 10.1016/J.Bmcl.2012.01.050  0.341
2012 Raje MR, Knott K, Kharel Y, Bissel P, Lynch KR, Santos WL. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & Medicinal Chemistry. 20: 183-94. PMID 22137932 DOI: 10.1016/J.Bmc.2011.11.011  0.377
2012 Callihan P, Zitomer NC, Stoeling MV, Kennedy PC, Lynch KR, Riley RT, Hooks SB. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology. 62: 988-96. PMID 22016110 DOI: 10.1016/J.Neuropharm.2011.10.005  0.789
2011 East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A  0.642
2011 Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817  0.791
2011 Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552  0.715
2011 Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48. PMID 21495716 DOI: 10.1021/Jm2001053  0.391
2011 Awad AS, Rouse MD, Khutsishvili K, Huang L, Bolton WK, Lynch KR, Okusa MD. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney International. 79: 1090-8. PMID 21289599 DOI: 10.1038/Ki.2010.544  0.393
2011 Kharel Y, Mathews TP, Kennedy AJ, Houck JD, Macdonald TL, Lynch KR. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical Biochemistry. 411: 230-5. PMID 21216217 DOI: 10.1016/J.Ab.2011.01.003  0.347
2011 Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404  0.433
2010 Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 62: 579-87. PMID 21079037 DOI: 10.1124/Pr.110.003111  0.522
2010 East JE, Kennedy AJ, Tomsig JL, De Leon AR, Lynch KR, Macdonald TL. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & Medicinal Chemistry Letters. 20: 7132-6. PMID 20951039 DOI: 10.1016/J.Bmcl.2010.09.030  0.32
2010 Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 21: 955-65. PMID 20338995 DOI: 10.1681/Asn.2009060662  0.377
2010 Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H  0.64
2010 Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/J.Bmcl.2010.02.006  0.455
2010 Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Engineering. Part A. 16: 1801-9. PMID 20038198 DOI: 10.1089/Ten.Tea.2009.0539  0.363
2010 Bajwa A, Jo S, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. 42: Activation of Proximal Tubule Sphingosine 1-Phosphate Receptor 1 Protects Kidneys From Ischemia Reperfusion Injury Independent of Lymphocytes American Journal of Kidney Diseases. 55: B42. DOI: 10.1053/J.Ajkd.2010.02.049  0.349
2009 Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015  0.811
2009 Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. Journal of Neurochemistry. 110: 1191-202. PMID 19493165 DOI: 10.1111/J.1471-4159.2009.06202.X  0.505
2009 Tomsig JL, Snyder AH, Berdyshev EV, Skobeleva A, Mataya C, Natarajan V, Brindley DN, Lynch KR. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. The Biochemical Journal. 419: 611-8. PMID 19215222 DOI: 10.1042/Bj20081888  0.702
2009 Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis. 48: 801-9. PMID 19204929 DOI: 10.1002/Mc.20524  0.345
2009 Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Letters. 276: 171-9. PMID 19131156 DOI: 10.1016/J.Canlet.2008.11.025  0.409
2009 Jo SK, Bajwa A, Ye H, Vergis AL, Awad AS, Kharel Y, Lynch KR, Okusa MD. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney International. 75: 167-75. PMID 18971925 DOI: 10.1038/Ki.2008.400  0.348
2008 Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Molecular Cancer Research : McR. 6: 1649-56. PMID 18922980 DOI: 10.1158/1541-7786.Mcr-07-2048  0.418
2008 Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circulation Research. 103: 662-70. PMID 18703779 DOI: 10.1161/Circresaha.108.180778  0.393
2008 Lynch KR, Macdonald TL. Sphingosine 1-phosphate chemical biology. Biochimica Et Biophysica Acta. 1781: 508-12. PMID 18638568 DOI: 10.1016/J.Bbalip.2008.06.006  0.348
2008 Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392  0.47
2008 Rivera-Lopez CM, Tucker AL, Lynch KR. Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis. 11: 301-10. PMID 18504643 DOI: 10.1007/S10456-008-9113-5  0.75
2008 van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR, Moolenaar WH. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters. 266: 203-8. PMID 18378389 DOI: 10.1016/J.Canlet.2008.02.052  0.407
2008 Hughes JE, Srinivasan S, Lynch KR, Proia RL, Ferdek P, Hedrick CC. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circulation Research. 102: 950-8. PMID 18323526 DOI: 10.1161/Circresaha.107.170779  0.382
2008 Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney International. 73: 1220-30. PMID 18322542 DOI: 10.1038/Ki.2008.34  0.45
2008 Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC. Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes. 57: 484-93. PMID 18003758 DOI: 10.2337/Db07-0855  0.333
2007 Okusa MD, Lynch KR. Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug Discovery Today. Disease Mechanisms. 4: 55-59. PMID 19448841 DOI: 10.1016/J.Ddmec.2007.07.001  0.468
2007 Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172  0.812
2007 Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 1634-40. PMID 17257836 DOI: 10.1016/J.Bmcl.2006.12.114  0.517
2007 Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200  0.525
2007 Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 15: 663-77. PMID 17113298 DOI: 10.1016/J.Bmc.2006.10.060  0.764
2006 Awad AS, Ye H, Huang L, Li L, Foss FW, Macdonald TL, Lynch KR, Okusa MD. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology. Renal Physiology. 290: F1516-24. PMID 16403835 DOI: 10.1152/Ajprenal.00311.2005  0.437
2006 Wamhoff BR, Lynch K, Owens GK. Differential regulation of smooth muscle cell phenotype by sphingosine-1-phosphate receptors. The Faseb Journal. 20. DOI: 10.1096/Fasebj.20.4.A699-C  0.377
2005 Foss FW, Clemens JJ, Davis MD, Snyder AH, Zigler MA, Lynch KR, Macdonald TL. Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4. PMID 16125386 DOI: 10.1016/J.Bmcl.2005.07.057  0.748
2005 Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S, Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of Biological Chemistry. 280: 36865-72. PMID 16093248 DOI: 10.1074/Jbc.M506293200  0.739
2005 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72. PMID 15982878 DOI: 10.1016/J.Bmcl.2005.05.097  0.5
2005 Lee S, Lynch KR. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). The Biochemical Journal. 391: 317-23. PMID 15926888 DOI: 10.1042/Bj20050043  0.514
2005 Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81. PMID 15761190 DOI: 10.1161/01.Atv.0000162171.30089.F6  0.409
2005 Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41. PMID 15590668 DOI: 10.1074/Jbc.M412356200  0.502
2004 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6. PMID 15341948 DOI: 10.1016/J.Bmcl.2004.07.030  0.51
2004 Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 4069-74. PMID 15225728 DOI: 10.1016/J.Bmcl.2004.05.023  0.479
2004 Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 14: 3473-6. PMID 15177455 DOI: 10.1016/J.Bmcl.2004.04.061  0.457
2004 Heasley BH, Jarosz R, Lynch KR, Macdonald TL. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 2735-40. PMID 15125924 DOI: 10.1016/J.Bmcl.2004.03.076  0.495
2004 Steinke JW, Crouse CD, Bradley D, Hise K, Lynch K, Kountakis SE, Borish L. Characterization of Interleukin-4-Stimulated Nasal Polyp Fibroblasts American Journal of Respiratory Cell and Molecular Biology. 30: 212-219. PMID 12920052 DOI: 10.1165/Rcmb.2003-0071Oc  0.352
2003 Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, Suhr KB, Milstien S, Spiegel S. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry. 42: 12181-91. PMID 14567679 DOI: 10.1021/Bi035051Y  0.493
2003 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4. PMID 14505636 DOI: 10.1016/S0960-894X(03)00812-6  0.497
2003 Okusa MD, Ye H, Huang L, Sigismund L, Macdonald T, Lynch KR. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. American Journal of Physiology. Renal Physiology. 285: F565-74. PMID 12770838 DOI: 10.1152/Ajprenal.00023.2003  0.379
2003 Hasegawa Y, Erickson JR, Goddard GJ, Yu S, Liu S, Cheng KW, Eder A, Bandoh K, Aoki J, Jarosz R, Schrier AD, Lynch KR, Mills GB, Fang X. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. The Journal of Biological Chemistry. 278: 11962-9. PMID 12554733 DOI: 10.1074/Jbc.M209168200  0.535
2002 Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proceedings of the National Academy of Sciences of the United States of America. 99: 17179-84. PMID 12482951 DOI: 10.1073/Pnas.252537299  0.389
2002 Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K. Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain. 99: 11-9. PMID 12237180 DOI: 10.1016/S0304-3959(02)00032-5  0.395
2002 Brinkmann V, Lynch KR. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Current Opinion in Immunology. 14: 569-75. PMID 12183155 DOI: 10.1016/S0952-7915(02)00374-6  0.423
2002 Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochimica Et Biophysica Acta. 1582: 289-94. PMID 12069840 DOI: 10.1016/S1388-1981(02)00183-X  0.445
2002 Lynch KR. Lysophospholipid receptor nomenclature. Biochimica Et Biophysica Acta. 1582: 70-1. PMID 12069811 DOI: 10.1016/S1388-1981(02)00138-5  0.458
2002 Takafuji VA, Evans A, Lynch KR, Roche JK. PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 66: 71-81. PMID 12051958 DOI: 10.1054/Plef.2001.0299  0.354
2002 Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 54: 265-9. PMID 12037142 DOI: 10.1124/Pr.54.2.265  0.518
2002 Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemistry. 277: 21453-7. PMID 11967257 DOI: 10.1074/Jbc.C200176200  0.69
2001 Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, Lynch KR. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Molecular Pharmacology. 60: 1173-80. PMID 11723223 DOI: 10.1124/Mol.60.6.1173  0.736
2001 Lee DK, George SR, Evans JF, Lynch KR, O'Dowd BF. Orphan G protein-coupled receptors in the CNS. Current Opinion in Pharmacology. 1: 31-9. PMID 11712532 DOI: 10.1016/S1471-4892(01)00003-0  0.361
2001 Im DS, Clemens J, Macdonald TL, Lynch KR. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60. PMID 11705398 DOI: 10.1021/Bi011606I  0.472
2001 Takafuji V, Lublin D, Lynch K, Roche JK. Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis Histochemistry and Cell Biology. 116: 171-181. PMID 11685545 DOI: 10.1007/S004180100287  0.46
2001 Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene. 275: 83-91. PMID 11574155 DOI: 10.1016/S0378-1119(01)00651-5  0.378
2001 Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. The Journal of Cell Biology. 153: 429-34. PMID 11309421 DOI: 10.1083/Jcb.153.2.429  0.705
2001 Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101  0.35
2001 Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Molecular Pharmacology. 59: 427-33. PMID 11179435 DOI: 10.1124/Mol.59.3.427  0.568
2001 Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Research. Molecular Brain Research. 86: 13-22. PMID 11165367 DOI: 10.1016/S0169-328X(00)00242-4  0.4
2001 Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. The Journal of Biological Chemistry. 276: 4611-21. PMID 11042183 DOI: 10.1074/Jbc.M007782200  0.816
2000 Im DS, Ungar AR, Lynch KR. Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. Biochemical and Biophysical Research Communications. 279: 139-43. PMID 11112429 DOI: 10.1006/Bbrc.2000.3933  0.458
2000 Takafuji V, Cosme R, Lublin D, Lynch K, Roche JK. Prostanoid receptors in intestinal epithelium: Selective expression, function, and change with inflammation Prostaglandins Leukotrienes and Essential Fatty Acids. 63: 223-235. PMID 11049698 DOI: 10.1016/S0016-5085(00)85381-0  0.427
2000 Cosme R, Lublin D, Takafuji V, Lynch K, Roche JK. Prostanoids in human colonic mucosa: Effects of inflammation on PGE2 receptor expression Human Immunology. 61: 684-696. PMID 10880739 DOI: 10.1016/S0016-5085(00)85326-3  0.421
2000 Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Lynch KR, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/Jbc.M003490200  0.75
2000 Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. The Journal of Biological Chemistry. 275: 14281-6. PMID 10799507 DOI: 10.1074/Jbc.275.19.14281  0.704
2000 Im DS, Heise CE, Harding MA, George SR, O'Dowd BF, Theodorescu D, Lynch KR. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Molecular Pharmacology. 57: 753-9. PMID 10727522 DOI: 10.1124/Mol.57.4.753  0.725
2000 Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. Cloning and characterization of additional members of the G protein-coupled receptor family. Biochimica Et Biophysica Acta. 1490: 311-23. PMID 10684976 DOI: 10.1016/S0167-4781(99)00241-9  0.421
1999 Lynch KR, Im DS. Life on the edg. Trends in Pharmacological Sciences. 20: 473-5. PMID 10603487 DOI: 10.1016/S0165-6147(99)01401-7  0.353
1999 Marchese A, George SR, Kolakowski LF, Lynch KR, O'Dowd BF. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends in Pharmacological Sciences. 20: 370-5. PMID 10462760 DOI: 10.1016/S0165-6147(99)01366-8  0.43
1999 Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658  0.74
1999 Hopper DW, Ragan SP, Hooks SB, Lynch KR, Macdonald TL. Structure--activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. Journal of Medicinal Chemistry. 42: 963-70. PMID 10090779 DOI: 10.1021/Jm970809V  0.739
1999 Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. Discovery of three novel orphan G-protein-coupled receptors. Genomics. 56: 12-21. PMID 10036181 DOI: 10.1006/Geno.1998.5655  0.417
1999 Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. Brain Research. Molecular Brain Research. 64: 193-8. PMID 9931487 DOI: 10.1016/S0169-328X(98)00277-0  0.392
1999 Im DS, Hooks SB, Lynch KR. Molecular pharmacology of lipid phosphoric acid receptors Proceedings of the Western Pharmacology Society. 42: 144.  0.696
1998 Hooks SB, Ragan SP, Lynch KR. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. Febs Letters. 427: 188-92. PMID 9607309 DOI: 10.1016/S0014-5793(98)00421-9  0.654
1998 Lee A, Wissekerke AE, Rosin DL, Lynch KR. Localization of alpha2C-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system. Neuroscience. 84: 1085-96. PMID 9578397 DOI: 10.1016/S0306-4522(97)00578-2  0.571
1998 O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR. Discovery of three novel G-protein-coupled receptor genes. Genomics. 47: 310-3. PMID 9479505 DOI: 10.1006/Geno.1998.5095  0.405
1998 Hooks SB, Ragan SP, Hopper DW, Hönemann CW, Durieux ME, Macdonald TL, Lynch KR. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Molecular Pharmacology. 53: 188-94. PMID 9463475 DOI: 10.1124/Mol.53.2.188  0.725
1998 Takafuji V, Lublin D, Lynch K, Roche J. Prostanoid receptors on human gastric mucosa: Localization and type Gastroenterology. 114: A686. DOI: 10.1016/S0016-5085(98)82814-X  0.336
1998 Worledge K, Takafuji V, Lublin D, Lynch K, Roche J. Localization of prostanoid G-protein coupled receptors in human colonic mucosa Gastroenterology. 114: A433. DOI: 10.1016/S0016-5085(98)81755-1  0.376
1997 Lynch KR, Hopper DW, Carlisle SJ, Catalano JG, Zhang M, MacDonald TL. Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety. Molecular Pharmacology. 52: 75-81. PMID 9224815 DOI: 10.1124/Mol.52.1.75  0.345
1997 O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene. 187: 75-81. PMID 9073069 DOI: 10.1016/S0378-1119(96)00722-6  0.337
1997 Jung BP, Nguyen T, Kolakowski LF, Lynch KR, Heng HHQ, George SR, O'Dowd BF. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1 Biochemical and Biophysical Research Communications. 230: 69-72. PMID 9020062 DOI: 10.1006/Bbrc.1996.5828  0.438
1996 Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HHQ, George SR, O'Dowd BF. Characterization of a human gene related to genes encoding somatostatin receptors Febs Letters. 398: 253-258. PMID 8977118 DOI: 10.1016/S0014-5793(96)01160-X  0.383
1996 D'Angelo DD, Terasawa T, Carlisle SJ, Dorn GW, Lynch KR. Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP. Prostaglandins. 52: 303-16. PMID 8936585 DOI: 10.1016/S0090-6980(96)00091-3  0.402
1996 Rosin DL, Talley EM, Lee A, Stornetta RL, Gaylinn BD, Guyenet PG, Lynch KR. Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. The Journal of Comparative Neurology. 372: 135-65. PMID 8841925 DOI: 10.1002/(Sici)1096-9861(19960812)372:1<135::Aid-Cne9>3.0.Co;2-4  0.46
1996 O'Dowd BF, Nguyen T, Lynch KR, Kolakowski LF, Thompson M, Cheng R, Marchese A, Ng G, Heng HH, George SR. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. Febs Letters. 394: 325-9. PMID 8830667 DOI: 10.1016/0014-5793(96)00901-5  0.421
1995 Lee A, Talley E, Rosin DL, Lynch KR. Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells. Neuroendocrinology. 62: 215-25. PMID 8538858 DOI: 10.1159/000127007  0.47
1995 Stornetta RL, Huangfu D, Rosin DL, Lynch KR, Guyenet PG. Alpha-2 adrenergic receptors. Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine. Annals of the New York Academy of Sciences. 763: 541-51. PMID 7677372 DOI: 10.1111/J.1749-6632.1995.Tb32448.X  0.358
1994 Durieux ME, Salafranca MN, Lynch KR. Trypsin induces Ca2+-activated Cl- currents in X. laevis oocytes Febs Letters. 337: 235-238. PMID 8293805 DOI: 10.1016/0014-5793(94)80198-3  0.35
1994 Harrison JK, Barber CM, Lynch KR. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors Neuroscience Letters. 169: 85-89. PMID 8047298 DOI: 10.1016/0304-3940(94)90362-X  0.372
1994 Okusa MD, Lynch KR, Rosin DL, Huang L, Wei YY. Apical membrane and intracellular distribution of endogenous α2A-adrenergic receptors in MDCK cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267: F347-F353. PMID 7916533 DOI: 10.1152/Ajprenal.1994.267.3.F347  0.333
1994 Lynch KR, Harrison JK, Pearson WR. Classification of Adrenergic Receptor Subtypes: Molecular Biologic Approaches Neuroprotocols. 4: 14-19. DOI: 10.1006/Ncmn.1994.1003  0.429
1993 Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW. Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2 Molecular and Cellular Biology. 13: 4539-4548. PMID 8393135 DOI: 10.1128/Mcb.13.8.4539  0.341
1993 Harrison JK, Barber CM, Lynch KR. Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver Febs Letters. 318: 17-22. PMID 8382168 DOI: 10.1016/0014-5793(93)81318-T  0.353
1993 Wu J, Harrison JK, Vincent LA, Haystead C, Haystead TAJ, Michel H, Hunt DF, Lynch KR, Sturgill TW. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase Proceedings of the National Academy of Sciences of the United States of America. 90: 173-177. PMID 8380494 DOI: 10.1073/Pnas.90.1.173  0.313
1993 Durieux ME, Lynch KR. Signalling properties of lysophosphatidic acid Trends in Pharmacological Sciences. 14: 249-254. PMID 8372406 DOI: 10.1016/0165-6147(93)90021-B  0.392
1993 Rosin DL, Zeng D, Stornetta RL, Norton FR, Riley T, Okusa MD, Guyenet PG, Lynch KR. Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience. 56: 139-55. PMID 7901804 DOI: 10.1016/0306-4522(93)90569-2  0.376
1993 Durieux ME, Carlisle SJ, Salafranca MN, Lynch KR. Responses to sphingosine-1-phosphate in X. laevis oocytes: Similarities with lysophosphatidic acid signaling American Journal of Physiology - Cell Physiology. 264: C1360-C1364. PMID 7684565 DOI: 10.1152/Ajpcell.1993.264.5.C1360  0.382
1993 Gaylinn BD, Harrison JK, Zysk JR, Lyons CE, Lynch KR, Thorner MO. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone Molecular Endocrinology. 7: 77-84. PMID 7680413 DOI: 10.1210/Mend.7.1.7680413  0.427
1992 Tucker AL, Linden J, Robeva AS, D'Angelo DD, Lynch KR. Cloning and expression of a bovine adenosine A1 receptor cDNA. Febs Letters. 297: 107-11. PMID 1551415 DOI: 10.1016/0014-5793(92)80338-H  0.441
1992 Durieux ME, Salafranca MN, Lynch KR, Moorman JR. Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes. The American Journal of Physiology. 263: C896-900. PMID 1415674 DOI: 10.1152/Ajpcell.1992.263.4.C896  0.335
1991 Harrison JK, Pearson WR, Lynch KR. Molecular characterization of α1- and α2-adrenoceptors Trends in Pharmacological Sciences. 12: 62-67. PMID 2024290 DOI: 10.1016/0165-6147(91)90499-I  0.405
1991 Linden J, Tucker AL, Lynch KR. Molecular cloning of adenosine A1 and A2 receptors Trends in Pharmacological Sciences. 12: 326-328. PMID 1949201 DOI: 10.1016/0165-6147(91)90589-K  0.305
1991 Harrison JK, D'Angelo DD, Zeng DW, Lynch KR. Pharmacological characterization of rat alpha 2-adrenergic receptors. Molecular Pharmacology. 40: 407-12. PMID 1654514  0.314
1991 Zeng D, Lynch KR. Distribution of α2-adrenergic receptor mRNAs in the rat CNS Molecular Brain Research. 10: 219-225. PMID 1653390 DOI: 10.1016/0169-328X(91)90064-5  0.308
1990 Zeng DW, Harrison JK, D'Angelo DD, Barber CM, Tucker AL, Lu ZH, Lynch KR. Molecular characterization of a rat alpha 2B-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 3102-6. PMID 2158103 DOI: 10.1073/Pnas.87.8.3102  0.363
1990 Ross PC, Figler RA, Corjay MH, Barber CM, Adam N, Harcus DR, Lynch KR. RTA, a candidate G protein-coupled receptor: Cloning, sequencing, and tissue distribution Proceedings of the National Academy of Sciences of the United States of America. 87: 3052-3056. PMID 2109324 DOI: 10.1073/Pnas.87.8.3052  0.383
Low-probability matches (unlikely to be authored by this person)
1993 Sessa WC, Harrison JK, Luthin DR, Pollock JS, Lynch KR. Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension (Dallas, Tex. : 1979). 21: 934-8. PMID 7685005 DOI: 10.1161/01.Hyp.21.6.934  0.298
2016 Bajwa A, Huang L, Kurmaeva E, Ye H, Dondeti KR, Chroscicki P, Foley LS, Balogun ZA, Alexander KJ, Park H, Lynch KR, Rosin DL, Okusa MD. Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ. Journal of the American Society of Nephrology : Jasn. PMID 27799486 DOI: 10.1681/Asn.2016030306  0.296
2011 Slack-Davis JK, Lynch KR. Abstract 397: LPA promotes ovarian cancer mesothelial invasion by regulating VCAM-1 expression Cancer Research. 71: 397-397. DOI: 10.1158/1538-7445.Am2011-397  0.293
2017 Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL. Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3. Scientific Reports. 7: 127. PMID 28273928 DOI: 10.1038/S41598-017-00210-Y  0.292
1987 Johns DW, Carey RM, Ariel Gomez R, Lynch K, Inagami T, Saye J, Geary K, Farnsworth DE, Peach MJ. Isolation of renin-rich rat kidney cells Hypertension. 10: 488-496. PMID 2444536 DOI: 10.1161/01.Hyp.10.5.488  0.291
1989 Tamura S, Lynch KR, Larner J, Fox J, Yasui A, Kikuchi K, Suzuki Y, Tsuiki S. Molecular cloning of rat type 2C (IA) protein phosphatase mRNA Proceedings of the National Academy of Sciences of the United States of America. 86: 1796-1800. PMID 2538815 DOI: 10.1073/Pnas.86.6.1796  0.291
2018 Cao R, Li J, Kharel Y, Zhang C, Morris E, Santos WL, Lynch KR, Zuo Z, Hu S. Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke. Theranostics. 8: 6111-6120. PMID 30613286 DOI: 10.7150/Thno.29435  0.291
2015 Nakayama J, Raines TA, Lynch KR, Slack-Davis JK. Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1. Plos One. 10: e0120071. PMID 25769037 DOI: 10.1371/Journal.Pone.0120071  0.289
2011 Farmar JG, Wendling A, Lynch K, Tomsig J, Ratajczak MZ, Lu H, Salhotra A, Yang S, Huang X, Masri HE, Laughlin MJ. Cord Blood Plasma Enhances Migration of Hematopoietic Stem and Progenitor Cells (HSPC) Blood. 118: 2959-2959. DOI: 10.1182/Blood.V118.21.2959.2959  0.289
1991 Lynch KR, Peach MJ. Molecular biology of angiotensinogen Hypertension. 17: 263-269. PMID 1999356 DOI: 10.1161/01.Hyp.17.3.263  0.288
1988 Hamman HC, Gaffey LC, Lynch KR, Creutz CE. Cloning and characterization of a cDNA encoding bovine endonexin (chromobindin 4). Biochemical and Biophysical Research Communications. 156: 660-7. PMID 2847715 DOI: 10.1016/S0006-291X(88)80893-3  0.287
1993 Gomez RA, Norling LL, Wilfong N, Isakson P, Lynch KR, Hock R, Quesenberry P. Leukocytes synthesize angiotensinogen Hypertension. 21: 470-475. PMID 7681424 DOI: 10.1161/01.Hyp.21.4.470  0.285
1990 Saye J, Lynch KR, Peach MJ. Changes in angiotensinogen messenger RNA in differentiating 3T3-F442A adipocytes Hypertension. 15: 867-871. PMID 2351437 DOI: 10.1161/01.Hyp.15.6.867  0.285
1989 Saye JA, Cassis LA, Sturgill TW, Lynch KR, Peach MJ. Angiotensinogen gene expression in 3T3-L1 cells American Journal of Physiology - Cell Physiology. 256: 25/2. PMID 2465693 DOI: 10.1152/Ajpcell.1989.256.2.C448  0.285
2023 Shrader CW, Foster D, Kharel Y, Huang T, Lynch KR, Santos WL. Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 129516. PMID 37832799 DOI: 10.1016/j.bmcl.2023.129516  0.282
2022 Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, ... ... Lynch KR, et al. Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Science Translational Medicine. 14: eabj2681. PMID 35976996 DOI: 10.1126/scitranslmed.abj2681  0.281
1994 Okusa MD, Lynch KR, Rosin DL, Huang Liping, Wei Yuan Yuan. Apical membrane and intracellular distribution of endogenous alpha2A-adrenergic receptors in MDCK cells Am.J.Physiol.. 267: F347-F353.  0.279
1993 Sessa WC, Barber CM, Lynch KR. Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein Circulation Research. 72: 921-924. PMID 7680289 DOI: 10.1161/01.Res.72.4.921  0.279
2000 Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, ... ... Lynch KR, et al. Identification of receptors for neuromedin U and its role in feeding. Nature. 406: 70-4. PMID 10894543 DOI: 10.1038/35017610  0.277
2020 Li H, Sibley CD, Kharel Y, Huang T, Brown AM, Wonilowicz LG, Bevan DR, Lynch KR, Santos WL. Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors. Bioorganic & Medicinal Chemistry. 30: 115941. PMID 33385956 DOI: 10.1016/j.bmc.2020.115941  0.275
1987 Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR. Molecular cloning of rat renin cDNA and its gene Proceedings of the National Academy of Sciences of the United States of America. 84: 5605-5609. PMID 3039496 DOI: 10.1073/Pnas.84.16.5605  0.273
2003 Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Novel human G-protein-coupled receptors. Biochemical and Biophysical Research Communications. 305: 67-71. PMID 12732197 DOI: 10.1016/S0006-291X(03)00709-5  0.271
1990 Gomez RA, Chevalier RL, Everett AD, Elwood JP, Peach MJ, Lynch KR, Carey RM. Recruitment of renin gene-expressing cells in adult rat kidneys American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259: F660-F665. PMID 2221104 DOI: 10.1152/Ajprenal.1990.259.4.F660  0.268
1997 Kolakqwsk LF, Casares J, Marchese A, Johnson MP, Nguyen T, Lynch KR, George SR, O'Dowd B. Discovery, cloning, and characterization of a novel human G protein-coupled receptor genes Faseb Journal. 11: A1339.  0.268
1987 Lynch KR, Hawelu-Johnson CL, Guyenet PG. Localization of brain angiotensinogen mRNA by hybridization histochemistry. Brain Research. 388: 149-58. PMID 3476177 DOI: 10.1016/0169-328X(87)90008-8  0.267
1994 Tucker AL, Robeva AS, Taylor HE, Holeton D, Bockner M, Lynch KR, Linden J. A1 adenosine receptors: Two amino acids are responsible for species differences in ligand recognition Journal of Biological Chemistry. 269: 27900-27906. PMID 7961722  0.267
1987 Fatigati V, Washington JM, Lynch KR, Peach MJ, Miller ED. Presence of angiotensinogen messenger RNA in various cultured cell lines Hypertension. 9: III-25-III-30. PMID 3596787 DOI: 10.1161/01.Hyp.9.6_Pt_2.Iii25  0.267
2014 Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning Acta Biomaterialia. DOI: 10.1016/j.actbio.2014.08.007  0.266
2008 Cui P, McCalmont WF, Tomsig JL, Lynch KR, Macdonald TL. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorganic & Medicinal Chemistry. 16: 2212-25. PMID 18082408 DOI: 10.1016/J.Bmc.2007.11.078  0.265
1995 Mnich SJ, Veenhuizen AW, Monahan JB, Sheehan KC, Lynch KR, Isakson PC, Portanova JP. Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2. Journal of Immunology (Baltimore, Md. : 1950). 155: 4437-44. PMID 7594605  0.262
2023 Kharel Y, Huang T, Santos WL, Lynch KR. Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors. Slas Discovery : Advancing Life Sciences R & D. PMID 37454972 DOI: 10.1016/j.slasd.2023.07.001  0.26
1994 Guyenet PG, Stornetta RL, Riley T, Norton FR, Rosin DL, Lynch KR. Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Research. 638: 285-94. PMID 7911062 DOI: 10.1016/0006-8993(94)90661-0  0.259
1981 Nakhasi HL, Lynch KR, Dolan KP, Unterman RD, Feigelson P. Covalent modification and repressed transcription of a gene in hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 834-7. PMID 7015332 DOI: 10.1073/Pnas.78.2.834  0.258
1981 Unterman RD, Lynch KR, Nakhasi HL, Dolan KP, Hamilton JW, Cohn DV, Feigelson P. Cloning and sequence of several alpha 2u-globulin cDNAs. Proceedings of the National Academy of Sciences of the United States of America. 78: 3478-82. PMID 6167987 DOI: 10.1073/Pnas.78.6.3478  0.257
1988 Gomez RA, Lynch KR, Chevalier RL, Everett AD, Johns DW, Wilfong N, Peach MJ, Carey RM. Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 254: 23/6. PMID 2837909 DOI: 10.1152/Ajprenal.1988.254.6.F900  0.257
1988 Cassis LA, Lynch KR, Peach MJ. Localization of angiotensinogen messenger RNA in rat aorta Circulation Research. 62: 1259-1262. PMID 3383369 DOI: 10.1161/01.Res.62.6.1259  0.254
2018 Mehaffey JH, Charles EJ, Narahari AK, Schubert S, Laubach VE, Teman NR, Lynch KR, Kron IL, Sharma AK. Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion. The Journal of Thoracic and Cardiovascular Surgery. PMID 29609890 DOI: 10.1016/J.Jtcvs.2018.02.090  0.25
1988 Stornetta RL, Hawelu-Johnson CL, Guyenet PG, Lynch KR. Astrocytes synthesize angiotensinogen in brain. Science (New York, N.Y.). 242: 1444-6. PMID 3201232 DOI: 10.1126/Science.3201232  0.249
2017 Adamiak M, Chelvarajan L, Lynch KR, Santos WL, Abdel-Latif A, Ratajczak MZ. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. PMID 28767388 DOI: 10.18632/oncotarget.19514  0.248
1989 Gomez RA, Lynch KR, Sturgill BC, Elwood JP, Chevalier RL, Carey RM, Peach MJ. Distribution of renin mRNA and its protein in the developing kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 257: 26/5. PMID 2686465 DOI: 10.1152/Ajprenal.1989.257.5.F850  0.248
2020 Congdon M, Fritzemeier RG, Kharel Y, Brown AM, Serbulea V, Bevan DR, Lynch KR, Santos WL. Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors. European Journal of Medicinal Chemistry. 212: 113121. PMID 33445156 DOI: 10.1016/j.ejmech.2020.113121  0.247
1999 Retief JD, Lynch KR, Pearson WR. Panning for genes--A visual strategy for identifying novel gene orthologs and paralogs. Genome Research. 9: 373-82. PMID 10207159 DOI: 10.1101/Gr.9.4.373  0.242
1988 Gomez RA, Lynch KR, Chevalier RL, Wilfong N, Everett A, Carey RM, Peach MJ. Renin and angiotensinogen gene expression in maturing rat kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 254: 23/4. PMID 3281475 DOI: 10.1152/Ajprenal.1988.254.4.F582  0.241
2010 Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, Kipnis J. Regulation of learning and memory by meningeal immunity: a key role for IL-4. The Journal of Experimental Medicine. 207: 1067-80. PMID 20439540 DOI: 10.1084/Jem.20091419  0.241
1988 Gomez RA, Cassis L, Lynch KR, Chevalier RL, Wilfong N, Carey RM, Peach MJ. Fetal expression of the angiotensinogen gene Endocrinology. 123: 2298-2302. PMID 3168925 DOI: 10.1210/Endo-123-5-2298  0.238
2004 Lickliter J, Arthur C, D’Rozario J, Hui C, Szer J, Taylor K, Watson A, McCarron J, Lynch K, Bradstock K. Phase II Pilot Study of Imatinib Mesylate Combined with Induction Chemotherapy in Blast-Phase CML and Ph+ ALL. Blood. 104: 4682-4682. DOI: 10.1182/Blood.V104.11.4682.4682  0.234
1995 Lynch KR. Preparation and characterization of antibodies directed against G-protein-coupled receptors Pharmacology Communications. 6: 147-153.  0.233
2023 Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN. Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects. The Journal of General Physiology. 156. PMID 37943249 DOI: 10.1085/jgp.202313419  0.233
2023 Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN. Novel TRPM7 inhibitors with potent anti-inflammatory effects . Biorxiv : the Preprint Server For Biology. PMID 37662207 DOI: 10.1101/2023.05.22.541802  0.23
2003 Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Brinkmann V, Nadler JL, Lynch KR. The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice. Clinical Immunology (Orlando, Fla.). 107: 30-5. PMID 12738247 DOI: 10.1016/S1521-6616(02)00054-2  0.229
1988 Purkerson JM, Newberg M, Wise G, Lynch KR, Isakson PC. Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells Journal of Experimental Medicine. 168: 1175-1180. PMID 3262706 DOI: 10.1084/Jem.168.3.1175  0.226
2014 Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, ... ... Lynch KR, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Molecular Metabolism. 3: 114-23. PMID 24634817 DOI: 10.1016/J.Molmet.2013.11.005  0.225
2004 Branford S, Rudzki Z, Parkinson I, Grigg A, Taylor K, Seymour JF, Durrant S, Browett P, Schwarer AP, Arthur C, Catalano J, Leahy MF, Filshie R, Bradstock K, Herrmann R, ... ... Lynch K, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood. 104: 2926-32. PMID 15256429 DOI: 10.1182/Blood-2004-03-1134  0.217
2014 Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism. 3: 124-34. PMID 24634818 DOI: 10.1016/J.Molmet.2013.11.003  0.21
1983 Dolan KP, Reinke R, Lynch KR, McLaughlin M, Unterman R, Nakhasi HL, Laperche Y, Feigelson P. CHAPTER 1 – The Application of Recombinant Techniques to the Study of the Control of α2u Globulin Gene Expression Biochemical Actions of Hormones. 1-22. DOI: 10.1016/B978-0-12-452810-9.50006-1  0.206
2003 Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J, Taylor K, Herrmann R, Seymour JF, Arthur C, Joske D, Lynch K, Hughes T. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis Blood. 102: 276-283. PMID 12623848 DOI: 10.1182/Blood-2002-09-2896  0.204
2008 Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM, Lynch K, Vernon-Roberts B, Zannettino AC. Long-term imatinib therapy promotes bone formation in CML patients. Blood. 111: 2538-47. PMID 18042796 DOI: 10.1182/blood-2007-07-104281  0.195
1996 Graham RM, Neubig R, Lynch KR. alpha 2-Adrenoceptors take centre stage at Nashville meeting. Trends in Pharmacological Sciences. 17: 90-4. PMID 8936342 DOI: 10.1016/0165-6147(96)30004-7  0.195
2012 Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury (Journal of Immunology (2012) 189 (2584-2596)) Journal of Immunology. 189: 4696. DOI: 10.4049/jimmunol.1290066  0.186
2000 Goetzl EJ, Lynch KR. Preface: the omnific lysophospholipid growth factors. Annals of the New York Academy of Sciences. 905: xi-xiv. PMID 10818435 DOI: 10.1111/J.1749-6632.2000.Tb06531.X  0.185
2002 Ekert-Jaffe O, Joshi H, Lynch K, Mougin R, Rendall M, Shapiro D. Fertility, Timing of Births and Socio-economic Status in France and Britain: Social Policies and Occupational Polarization Population (English Edition, 2002-). 57: 475. DOI: 10.2307/3246636  0.181
2002 Ekert-Jaffe O, Joshi H, Lynch K, Mougin R, Rendall M. Fecondite, calendrier des naissances et milieu social en France et en Grande-Bretagne: Politiques sociales et polarisation socioprofessionnelle Population (French Edition). 57: 485. DOI: 10.2307/1535056  0.18
2000 Lynch K, Fernandez G, Pappalardo A, Peluso JJ. Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase Cδ-dependent pathway Endocrinology. 141: 4209-4217. PMID 11089555  0.178
2004 Pan B, Farrugia AN, To LB, Findlay DM, Green J, Lynch K, Zannettino AC. The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 147-54. PMID 14753746 DOI: 10.1359/jbmr.2004.19.1.147  0.174
1992 Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, Peach MJ. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. The Journal of Biological Chemistry. 267: 15274-6. PMID 1379225  0.169
2023 Egan H, Treacy O, Lynch K, Leonard NA, O'Malley G, Reidy E, O'Neill A, Corry SM, De Veirman K, Vanderkerken K, Egan LJ, Ritter T, Hogan AM, Redmond K, Peng L, et al. Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment. Cell Reports. 112475. PMID 37167967 DOI: 10.1016/j.celrep.2023.112475  0.166
1987 Harrison JR, Lynch KR, Sando JJ. Phorbol esters induce interleukin 2 mRNA in sensitive but not in resistant EL4 cells Journal of Biological Chemistry. 262: 234-238. PMID 3491822  0.166
2006 Tan A, Westerman D, McArthur GA, Lynch K, Waring P, Dobrovic A. Sensitive detection of KIT D816V in patients with mastocytosis. Clinical Chemistry. 52: 2250-7. PMID 17040960 DOI: 10.1373/clinchem.2006.068205  0.16
2004 Pan B, To LB, Farrugia AN, Findlay DM, Green J, Gronthos S, Evdokiou A, Lynch K, Atkins GJ, Zannettino AC. The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone. 34: 112-23. PMID 14751568  0.151
1989 Ben-Ari ET, Lynch KR, Garrison JC. Glucocorticoids induce the accumulation of novel angiotensinogen gene transcripts Journal of Biological Chemistry. 264: 13074-13079. PMID 2546946  0.151
2021 Naicker SD, Feerick CL, Lynch K, Swan D, McEllistrim C, Henderson R, Leonard NA, Treacy O, Natoni A, Rigalou A, Cabral J, Chiu C, Sasser K, Ritter T, O'Dwyer M, et al. Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis. Oncoimmunology. 10: 1859263. PMID 33552684 DOI: 10.1080/2162402X.2020.1859263  0.151
1989 Corjay MH, Thompson MM, Lynch KR, Owens GK. Differential effect of platelet-derived growth factor- versus serum-induced growth on smooth muscle α-actin and nonmuscle β-actin mRNA expression in cultured rat aortic smooth muscle cells Journal of Biological Chemistry. 264: 10501-10506. PMID 2732233  0.148
2017 Lynch K, Treacy O, Gerlach JQ, Annuk H, Lohan P, Cabral J, Joshi L, Ryan AE, Ritter T. Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment. Frontiers in Immunology. 8: 1427. PMID 29163502 DOI: 10.3389/Fimmu.2017.01427  0.145
2018 Adamiak M, Chelvarajan L, Lynch KR, Santos WL, Abdel-Latif A, Ratajczak MZ. Correction: Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 9: 34189. PMID 30344931 DOI: 10.18632/oncotarget.26195  0.145
2022 Oyewole OO, Dunnavant K, Bhattarai S, Kharel Y, Lynch KR, Santos WL, Reid SP. A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection. Viruses. 14. PMID 35746595 DOI: 10.3390/v14061123  0.143
2007 White D, Saunders V, Grigg A, Arthur C, Filshie R, Leahy MF, Lynch K, To LB, Hughes T. Measurement of in vivo BCR-ABL kinase inhibition to monitor imatinib-induced target blockade and predict response in chronic myeloid leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 4445-51. PMID 17906206 DOI: 10.1200/Jco.2006.09.9499  0.138
1996 Talley EM, Rosin DL, Lee A, Guyenet PG, Lynch KR. Distribution of alpha 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. The Journal of Comparative Neurology. 372: 111-34. PMID 8841924 DOI: 10.1002/(SICI)1096-9861(19960812)372:1<111::AID-CNE8>3.0.CO;2-6  0.137
2017 Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A, Kumari A, Woll PS, Richards LA, Knezevic K, Chandrakanthan V, Thoms JAI, Tursky ML, Huang Y, Ali Z, Olivier J, ... ... Lynch K, et al. Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes. Cell Reports. 20: 572-585. PMID 28723562 DOI: 10.1016/J.Celrep.2017.06.067  0.133
2019 Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. TNF-α/IL-1β-licensed mesenchymal stromal cells promote corneal allograft survival myeloid cell-mediated induction of Foxp3 regulatory T cells in the lung. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900047R. PMID 31108041 DOI: 10.1096/fj.201900047R  0.131
1977 Cohen PS, Lynch KR, Walsh ML, Hill JM, Ennis HL. Use of antibiotics to determine ribosome-messenger RNA interactions necessary for in vivo stability of specific messengers Journal of Molecular Biology. 114: 569-573. PMID 915943 DOI: 10.1016/0022-2836(77)90179-6  0.128
2018 O'Malley G, Treacy O, Lynch K, Naicker SD, Leonard NA, Lohan P, Dunne PD, Ritter T, Egan LJ, Ryan AE. Stromal cell PD-L1 inhibits CD8+ T-cell antitumor immune responses and promotes colon cancer. Cancer Immunology Research. PMID 30228206 DOI: 10.1158/2326-6066.CIR-17-0443  0.125
1999 Marchese A, George SR, KolakowskiJr LF, Lynch KR, O'Dowd BF. Corrigendum Trends in Pharmacological Sciences. 20: 447. PMID 10542443  0.12
2014 Lynch K, Pei M. Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis. 10: 289-98. PMID 25482504 DOI: 10.4161/15476278.2014.970089  0.116
1983 Laperche Y, Lynch KR, Dolan KP, Feigelson P. Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland. Cell. 32: 453-60. PMID 6186396 DOI: 10.1016/0092-8674(83)90465-8  0.113
1977 Ennis HL, Walsh ML, Lynch KR, Hill JM, Cohen PS. Coupling of processing of α-glucosyl transferase mRNA with translation Biochemical and Biophysical Research Communications. 76: 1282-1286. PMID 332161 DOI: 10.1016/0006-291X(77)90994-9  0.111
2021 Treacy O, Lynch K, Murphy N, Chen X, Donohoe E, Canning A, Lohan P, Shaw G, Fahy G, Ryan AE, Ritter T. Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice. Stem Cell Research & Therapy. 12: 227. PMID 33823917 DOI: 10.1186/s13287-021-02293-x  0.107
2001 Lynch KR, Macdonald TL. Structure activity relationships of lysophospholipid mediators. Prostaglandins & Other Lipid Mediators. 64: 33-45. PMID 11324706 DOI: 10.1016/S0090-6980(01)00106-X  0.103
2024 Yuwen H, Wang H, Li T, Ren Y, Zhang YK, Chen P, Sun A, Bian G, Li B, Flowers D, Presler M, Subramanian K, Xue J, Wang J, Lynch K, et al. ATG-101 is a tetravalent PD-L1×4-1BB bispecific antibody that stimulates anti-tumor immunity through PD-L1 blockade and PD-L1-directed 4-1BB activation. Cancer Research. PMID 38501978 DOI: 10.1158/0008-5472.CAN-23-2701  0.102
1982 Lynch KR, Dolan KP, Nakhasi HL, Unterman R, Feigelson P. The role of growth hormone in alpha 2u globulin synthesis: a reexamination. Cell. 28: 185-9. PMID 6175426 DOI: 10.1016/0092-8674(82)90388-9  0.099
2019 Lynch K, De Veirman K, Egan H, Leonard N, O'Malley G, Ritter T, Ryan A, O'Dwyer M. Mesenchymal Stromal Cell Sialylation Modulates Antitumor Immune Responses In Multiple Myeloma Clinical Lymphoma Myeloma and Leukemia. 19: e93-e94. DOI: 10.1016/j.clml.2019.09.152  0.099
1982 Antakly T, Lynch KR, Nakhasi HL, Feigelson P. Cellular dynamics of the hormonal and developmental induction of hepatic alpha 2u globulin as demonstrated by immunocytochemistry and specific mRNA monitoring. The American Journal of Anatomy. 165: 211-24. PMID 6183971 DOI: 10.1002/Aja.1001650209  0.098
2020 Lynch K, Treacy O, Chen X, Murphy N, Lohan P, Islam MN, Donohoe E, Griffin MD, Watson L, McLoughlin S, O'Malley G, Ryan AE, Ritter T. TGF-β1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32531237 DOI: 10.1016/j.ymthe.2020.05.023  0.096
1989 Simpson L, McNiece I, Newberg M, Schetz J, Lynch KR, Quesenberry P, Isakson PC. Detection and characterization of a B cell stimulatory factor (BSF-TC) derived from a bone marrow stromal cell line Journal of Immunology. 142: 3894-3900. PMID 2785568  0.093
2008 Quach H, Ritchie D, Neeson P, Harrison S, Tai T, Tainton K, Lynch K, Prince M. Regulatory T Cells (Treg) Are Depressed in Patients with Relapsed/Refractory Multiple Myeloma (MM) and Increases towards Normal Range in Responding Patients Treated with Lenalidomide (LEN). Blood. 112: 1696-1696. DOI: 10.1182/blood.V112.11.1696.1696  0.091
2015 Pizzute T, Lynch K, Pei M. Impact of tissue-specific stem cells on lineage-specific differentiation: a focus on the musculoskeletal system. Stem Cell Reviews. 11: 119-32. PMID 25113801 DOI: 10.1007/S12015-014-9546-8  0.09
2013 Peyruchaud O, David M, Macdonald TL, Lynch KR. Lysophosphatidic Acid (LPA) Signaling and Bone Cancer Lysophospholipid Receptors: Signaling and Biochemistry. 627-640. DOI: 10.1002/9781118531426.ch29  0.09
2018 Lohan P, Murphy N, Treacy O, Lynch K, Morcos M, Chen B, Ryan AE, Griffin MD, Ritter T. Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation. Frontiers in Immunology. 9: 2666. PMID 30515159 DOI: 10.3389/fimmu.2018.02666  0.089
2007 White DL, Saunders VA, Dang P, Engler J, Venables A, Zrim S, Zannettino A, Lynch K, Manley PW, Hughes T. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood. 110: 4064-72. PMID 17761829 DOI: 10.1182/Blood-2007-06-093617  0.089
2005 Spencer A, Roberts A, Neeman T, Cremers S, Schran H, Lynch K. Zoledronic Acid Plus Thalidomide Is Safe and Well Tolerated When Used as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients with Nonprogressive Multiple Myeloma. Blood. 106: 2551-2551. DOI: 10.1182/Blood.V106.11.2551.2551  0.087
2023 Kharel Y, Huang T, Salamon A, Harris TE, Santos WL, Lynch KR. Correction: Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal. 480: 2059-2060. PMID 38108461 DOI: 10.1042/BCJ20190730_COR  0.084
2021 Kunk PR, Dougherty SC, Lynch K, Whitehair R, Meneveau M, Obeid JM, Winters K, Ju JY, Stelow EB, Bauer TW, Slingluff CL, Rahma OE. Myeloid Cell Infiltration Correlates With Prognosis in Cholangiocarcinoma and Varies Based on Tumor Location. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 34191790 DOI: 10.1097/CJI.0000000000000378  0.083
2008 Tirado CF, Goldman M, Lynch K, Kampman KM, Obrien CP. Atomoxetine for treatment of marijuana dependence: a report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study. Drug and Alcohol Dependence. 94: 254-7. PMID 18182254 DOI: 10.1016/j.drugalcdep.2007.10.020  0.081
2008 Spencer A, Roberts A, Kennedy N, Ravera C, Cremers S, Bilic S, Neeman T, Copeman M, Schran H, Lynch K. Renal safety of zoledronic acid with thalidomide in patients with myeloma: a pharmacokinetic and safety sub-study. Bmc Clinical Pharmacology. 8: 2-2. PMID 18377658 DOI: 10.1186/1472-6904-8-2  0.08
2023 Patel M, Teferi M, Casalvera A, Lynch K, Nitchie F, Makhoul W, Oathes DJ, Sheline Y, Balderston NL. Interleaved TMS/fMRI shows that threat decreases dlPFC-mediated top-down regulation of emotion processing. Medrxiv : the Preprint Server For Health Sciences. PMID 37986856 DOI: 10.1101/2023.11.11.23298414  0.08
2015 Lynch K, Maloney A, Sowell A, Wang C, Mo Y, Karty JM. Why is sulfuric acid a much stronger acid than ethanol? Determination of the contributions by inductive/field effects and electron-delocalization effects. Physical Chemistry Chemical Physics : Pccp. 17: 138-44. PMID 25316069 DOI: 10.1039/C4Cp04110K  0.08
1981 Lynch KR, Pennica D, Ennis HL, Cohen PS. Temporal regulation of the rate of vesicular stomatitis virus mRNA translation during infection of Chinese hamster ovary cells. Virology. 108: 277-85. PMID 6258290 DOI: 10.1016/0042-6822(81)90436-0  0.079
2008 Branford S, Fletcher L, Cross NC, Müller MC, Hochhaus A, Kim DW, Radich JP, Saglio G, Pane F, Kamel-Reid S, Wang YL, Press RD, Lynch K, Rudzki Z, Goldman JM, et al. Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials. Blood. 112: 3330-8. PMID 18684859 DOI: 10.1182/Blood-2008-04-150680  0.079
2005 Millward MJ, Joshua A, Kefford R, Aamdal S, Thomson D, Hersey P, Toner G, Lynch K. Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma. Investigational New Drugs. 23: 253-6. PMID 15868382 DOI: 10.1007/s10637-005-6734-z  0.079
1986 Lynch KR, Simnad VI, Ben-Ari ET, Garrison JC. Localization of preangiotensinogen messenger RNA sequences in the rat brain Hypertension. 8: 540-543. PMID 3710560  0.078
2003 Alterman AI, McDermott PA, Mulvaney FD, Cacciola JS, Rutherford MJ, Searles JS, Lynch K, Cnaan A. Comparison of embedded and isolated administrations of the California Psychological Inventory's Socialization subscale. Psychological Assessment. 15: 64-70. PMID 12674725 DOI: 10.1037/1040-3590.15.1.64  0.078
2007 Branford S, Fletcher L, Cross NC, Hochhaus A, Mueller MC, Kim D, Radich J, Saglio G, Pane F, Lynch K, Goldman JM, Hughes T. Validation of the International Scale for Measurement of BCR-ABL by RQ-PCR Based on Deriving Laboratory-Specific Conversion Factors. Blood. 110: 1013-1013. DOI: 10.1182/Blood.V110.11.1013.1013  0.078
2016 Murphy N, Lynch K, Lohan P, Treacy O, Ritter T. Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation. Current Opinion in Organ Transplantation. 21: 559-567. PMID 27801687 DOI: 10.1097/MOT.0000000000000360  0.074
2007 Branford S, Seymour JF, Grigg A, Arthur C, Rudzki Z, Lynch K, Hughes T. BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years and approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict sensitivity criteria. Clinical Cancer Research. 13: 7080-7085. PMID 18056186 DOI: 10.1158/1078-0432.Ccr-07-0844  0.072
2022 Qiu L, Xia Z, Fu C, Chen W, Chang C, Fang B, An G, Wei Y, Cai Z, Gao S, Weng J, Chen L, Jing H, Li F, Liu Z, ... ... Lynch K, et al. Selinexor plus low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma previously treated with an immunomodulatory agent and a proteasome inhibitor (MARCH): a phase II, single-arm study. Bmc Medicine. 20: 108. PMID 35379237 DOI: 10.1186/s12916-022-02305-4  0.072
2007 Branford S, Hughes T, Milner A, Koelmeyer R, Schwarer A, Arthur C, Filshie R, Moreton S, Lynch K, Taylor K. Efficacy and safety of imatinib in patients with chronic myeloid leukemia and complete or near‐complete cytogenetic response to interferon‐α Cancer. 110: 801-808. PMID 17607681 DOI: 10.1002/Cncr.22842  0.07
2022 Shannon AB, Straker RJ, Carr MJ, Sun J, Landa K, Baecher K, Lynch K, Bartels HG, Panchaud R, Keele LJ, Lowe MC, Slingluff CL, Jameson MJ, Tsai KY, Faries MB, et al. An Internally Validated Prognostic Risk-Score Model for Disease-Specific Survival in Clinical Stage I and II Merkel Cell Carcinoma. Annals of Surgical Oncology. PMID 35867209 DOI: 10.1245/s10434-022-12201-z  0.07
2019 Swan D, Lynch K, Gurney M, O'Dwyer M. Current and emerging immunotherapeutic approaches to the treatment of multiple myeloma. Therapeutic Advances in Hematology. 10: 2040620719854171. PMID 31244984 DOI: 10.1177/2040620719854171  0.068
2010 Benton T, Lynch K, Dubé B, Gettes DR, Tustin NB, Ping Lai J, Metzger DS, Blume J, Douglas SD, Evans DL. Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication. Psychosomatic Medicine. 72: 925-32. PMID 20947783 DOI: 10.1097/PSY.0b013e3181f883ce  0.065
2017 Mehaffey J, Charles E, Hawkins R, Schubert S, Kharel Y, Tribble C, Laubach V, Lynch K, Sharma A, Kron I. Sphingosine-1-Phosphate Attenuates Lung Injury in Murine Model of Ex Vivo Lung Perfusion The Journal of Heart and Lung Transplantation. 36: S91. DOI: 10.1016/j.healun.2017.01.230  0.064
2009 Lynch KR. A Next Generation Muon g - 2 Experiment Nuclear Physics B - Proceedings Supplements. 189: 201-207. DOI: 10.1016/j.nuclphysbps.2009.03.035  0.063
2012 Morgenstern J, Kuerbis A, Amrhein P, Hail L, Lynch K, McKay JR. Motivational interviewing: a pilot test of active ingredients and mechanisms of change. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. 26: 859-69. PMID 22905896 DOI: 10.1037/A0029674  0.059
2000 Goetzl EJ, Lynch KR. Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases by the New York Academy of Sciences, New York, NY, USA, 25-28 June 1999: Preface: The omnific lysophospholipid growth factors Annals of the New York Academy of Sciences. 905: xi-xiv.  0.058
2020 Samy ANW, Treacy O, Leonard N, Lynch K, Hynes S, Sheehan M, Egan L, Hogan A, Ryan A. AB066. Elucidating the circulating and tumour-specific immune populations in a cohort of colon cancer patients Mesentery and Peritoneum. 4: AB066-AB066. DOI: 10.21037/map.2020.ab066  0.057
2007 Chitwood DB, Banks TI, Barnes MJ, Battu S, Carey RM, Cheekatmalla S, Clayton SM, Crnkovic J, Crowe KM, Debevec PT, Dhamija S, Earle W, Gafarov A, Giovanetti K, Gorringe TP, ... ... Lynch KR, et al. Improved measurement of the positive-muon lifetime and determination of the Fermi constant. Physical Review Letters. 99: 032001. PMID 17678280 DOI: 10.1103/Physrevlett.99.032001  0.057
2016 Schearer E, Liao YW, Perreault E, Tresch M, Memberg W, Kirsch R, Lynch K. Semiparametric Identification of Human Arm Dynamics for Flexible Control of a Functional Electrical Stimulation Neuroprosthesis. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. PMID 26955041 DOI: 10.1109/TNSRE.2016.2535348  0.055
1979 Lynch KR, Pennica D, Ennis HL, Cohen PS. Separation and purification of the mRNAs for vesicular stomatitis virus NS and M proteins. Virology. 98: 251-4. PMID 225864 DOI: 10.1016/0042-6822(79)90543-9  0.054
1979 Pennica D, Lynch KR, Cohen PS, Ennis HL. Decay of vesicular stomatitis virus mRNAs in vivo. Virology. 94: 484-7. PMID 222066 DOI: 10.1016/0042-6822(79)90480-X  0.054
2013 Tishchenko V, Battu S, Carey RM, Chitwood DB, Crnkovic J, Debevec PT, Dhamija S, Earle W, Gafarov A, Giovanetti K, Gorringe TP, Gray FE, Hartwig Z, Hertzog DW, Johnson B, ... ... Lynch KR, et al. Detailed report of the MuLan measurement of the positive muon lifetime and determination of the Fermi constant Physical Review D - Particles, Fields, Gravitation and Cosmology. 87. DOI: 10.1103/Physrevd.87.052003  0.054
2015 Lickliter JD, Taylor K, Szer J, Grigg A, Arthur C, Hughes TP, Durrant S, Filshie R, Irving I, Seldon M, Ellacott J, Boyd AW, D'Rozario J, Rooney K, Lynch K, et al. An imatinib-only window followed by imatinib and chemotherapy for Philadelphia chromosome-positive acute leukemia: long-term results of the CMLALL1 trial. Leukemia & Lymphoma. 56: 630-8. PMID 24844361 DOI: 10.3109/10428194.2014.925547  0.053
2001 Lynch KR, Mrenna S, Narain M, Simmons EH. Finding Z′ bosons coupled preferentially to the third family at CERN LEP and the Fermilab Tevatron Physical Review D. 63. DOI: 10.1103/Physrevd.63.035006  0.053
2022 Shannon AB, Straker RJ, Carr MJ, Sun J, Landa K, Baecher K, Lynch K, Bartels HG, Panchaud R, Keele LJ, Lowe MC, Slingluff CL, Jameson MJ, Tsai KY, Faries MB, et al. ASO Visual Abstract: An Internally Validated Prognostic Risk Score Model for Disease-Specific Survival in Clinical Stage I and II Merkel Cell Carcinoma. Annals of Surgical Oncology. PMID 35896923 DOI: 10.1245/s10434-022-12293-7  0.052
2010 Quach H, Fernyhough L, Henderson R, Corbett G, Lynch K, Ritchie D, Harrison SJ, Prince HM. Lower-Dose Lenalidomide and Dexamethasone Reduces Toxicity without Compromising Efficacy In Patients with Relapsed/Refractory Myeloma, Who Are Aged ≥60 Years or Have Renal Impairment: Planned Interim Results of a Prospective Multicentre Phase II Trial Blood. 116: 1961-1961. DOI: 10.1182/blood.v116.21.1961.1961  0.051
2023 Kucuktabak EB, Wen Y, Short M, Demirbas E, Lynch K, Pons J. Virtual Physical Coupling of Two Lower-Limb Exoskeletons. Ieee ... International Conference On Rehabilitation Robotics : [Proceedings]. 2023: 1-6. PMID 37941279 DOI: 10.1109/ICORR58425.2023.10304601  0.05
2023 Short MR, Ludvig D, Kucuktabak EB, Wen Y, Vianello L, Perreault EJ, Hargrove L, Lynch K, Pons JL. Haptic Human-Human Interaction During an Ankle Tracking Task: Effects of Virtual Connection Stiffness. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. 31: 3864-3873. PMID 37747854 DOI: 10.1109/TNSRE.2023.3319291  0.05
2011 Webber DM, Tishchenko V, Peng Q, Battu S, Carey RM, Chitwood DB, Crnkovic J, Debevec PT, Dhamija S, Earle W, Gafarov A, Giovanetti K, Gorringe TP, Gray FE, Hartwig Z, ... ... Lynch KR, et al. Measurement of the positive muon lifetime and determination of the Fermi constant to part-per-million precision. Physical Review Letters. 106: 041803. PMID 21405320 DOI: 10.1103/Physrevlett.106.041803  0.05
2001 Lynch KR, Simmons EH. Composite scalars at CERN LEP: Constraining technicolor theories Physical Review D. 64. DOI: 10.1103/Physrevd.64.035008  0.05
2015 Andreev VA, Banks TI, Carey RM, Case TA, Clayton SM, Crowe KM, Deutsch J, Egger J, Freedman SJ, Ganzha VA, Gorringe T, Gray FE, Hertzog DW, Hildebrandt M, Kammel P, ... ... Lynch KR, et al. Measurement of the formation rate of muonic hydrogen molecules Physical Review C - Nuclear Physics. 91. DOI: 10.1103/Physrevc.91.055502  0.048
2023 Khazanov GK, Ingram E, Lynch K, Trim R, McKay J, Oslin DW. Validity and reliability of in-person and remote oral fluids drug testing compared to urine drug testing. Drug and Alcohol Dependence. 250: 110876. PMID 37429052 DOI: 10.1016/j.drugalcdep.2023.110876  0.047
2008 Gariti P, Levin S, Whittingham T, Barou D, Kampman KM, Lynch K, Halbert CH, Alterman A. Why do those who request smoking treatment fail to attend the first appointment? Journal of Substance Abuse Treatment. 35: 62-7. PMID 17931823 DOI: 10.1016/j.jsat.2007.08.009  0.046
2015 Golding JM, Lynch KR, Wasarhaley NE. Impeaching Rape Victims in Criminal Court: Does Concurrent Civil Action Hurt Justice? Journal of Interpersonal Violence. PMID 25944837 DOI: 10.1177/0886260515584342  0.045
2015 Dunlap EE, Lynch KR, Jewell JA, Wasarhaley NE, Golding JM. Participant gender, stalking myth acceptance, and gender role stereotyping in perceptions of intimate partner stalking: a structural equation modeling approach Psychology, Crime and Law. 21: 234-253. DOI: 10.1080/1068316X.2014.951648  0.045
2022 Tieniber AD, Shannon A, Carr MJ, Sun J, Landa K, Baecher KM, Lynch K, Bartels HG, Panchaud R, Lowe MC, Slingluff CL, Jameson MJ, Tsai KY, Faries MB, Beasley GM, et al. Patterns of Recurrence and Prognosis in Pathologic Stage I and II Merkel Cell Carcinoma: A multi-center, retrospective cohort analysis. Journal of the American Academy of Dermatology. PMID 35588924 DOI: 10.1016/j.jaad.2022.05.019  0.045
2005 Turner BJ, Laine C, Lin YT, Lynch K. Barriers and facilitators to primary care or human immunodeficiency virus clinics providing methadone or buprenorphine for the management of opioid dependence Archives of Internal Medicine. 165: 1769-1776. PMID 16087826 DOI: 10.1001/archinte.165.15.1769  0.044
2008 Hughes TP, Branford S, White DL, Reynolds J, Koelmeyer R, Seymour JF, Taylor K, Arthur C, Schwarer A, Morton J, Cooney J, Leahy MF, Rowlings P, Catalano J, Hertzberg M, ... ... Lynch K, et al. Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy. Blood. 112: 3965-73. PMID 18768781 DOI: 10.1182/blood-2008-06-161737  0.043
2014 Hodell EC, Wasarhaley NE, Lynch KR, Golding JM. Mock Juror Gender Biases and Perceptions of Self-Defense Claims in Intimate Partner Homicide Journal of Family Violence. 29: 495-506. DOI: 10.1007/S10896-014-9609-2  0.042
2009 McNabb R, Blackburn J, Crnkovic JD, Hertzog DW, Kiburg B, Kunkle J, Thorsland E, Webber DM, Lynch KR. A tungsten/scintillating fiber electromagnetic calorimeter prototype for a high-rate muon (g - 2) experiment Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 602: 396-402. DOI: 10.1016/j.nima.2009.01.007  0.042
2007 Caroff SN, Walker P, Campbell EC, Lorry A, Petro C, Lynch K, Gallop R. Treatment of tardive dyskinesia with galantamine: a randomized controlled crossover trial. The Journal of Clinical Psychiatry. 68: 410-415. PMID 17388711 DOI: 10.4088/Jcp.V68N0309  0.041
2023 Nitchie F, Casalvera A, Teferi M, Patel M, Lynch K, Makhoul W, Sheline Y, Balderston NL. The maintenance of complex visual scenes in working memory may require activation of working memory manipulation circuits in the dlPFC. Medrxiv : the Preprint Server For Health Sciences. PMID 37986871 DOI: 10.1101/2023.11.11.23298415  0.041
2022 Kim SJ, Wen Y, Ludvig D, Kucuktabak EB, Short MR, Lynch K, Hargrove L, Perreault EJ, Pons JL. Effect of Dyadic Haptic Collaboration on Ankle Motor Learning and Task Performance. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. PMID 36449583 DOI: 10.1109/TNSRE.2022.3225759  0.04
2015 Wasarhaley NE, Lynch KR, Golding JM, Renzetti CM. The Impact of Gender Stereotypes on Legal Perceptions of Lesbian Intimate Partner Violence. Journal of Interpersonal Violence. PMID 25990382 DOI: 10.1177/0886260515586370  0.039
2023 Yap J, J Dziak J, Maiti R, Lynch K, McKay JR, Chakraborty B, Nahum-Shani I. Sample size estimation for comparing dynamic treatment regimens in a SMART: A Monte Carlo-based approach and case study with longitudinal overdispersed count outcomes. Statistical Methods in Medical Research. 9622802231167435. PMID 37167008 DOI: 10.1177/09622802231167435  0.039
2013 Lynch KR, Wasarhaley NE, Golding JM, Simcic T. Who bought the drinks? Juror perceptions of intoxication in a rape trial. Journal of Interpersonal Violence. 28: 3205-22. PMID 23929601 DOI: 10.1177/0886260513496900  0.039
2016 Lynch K, Cho S, Andres R, Knight J, Con J. Pre-operative Identification and Surgical Management of the Appendiceal Mucocele: A Case Report. The West Virginia Medical Journal. 112: 28-30. PMID 27491099  0.039
2019 Piovesan D, Kolesnikov M, Lynch K, Mussa-Ivaldi FA. The Concurrent Control of Motion and Contact Force in the Presence of Predictable Disturbances. Journal of Mechanisms and Robotics. 11: 060903. PMID 34163561 DOI: 10.1115/1.4044599  0.037
2016 Leung A, Bonasso P, Lynch K, Long D, Vaughan R, Wilson A, Con J. Pediatric Secondary Overtriage in a Statewide Trauma System. The American Surgeon. 82: 763-7. PMID 27670555  0.037
2015 Magyarics CL, Lynch KR, Golding JM, Lippert A. The Impact of Frequency of Behavior and Type of Contact on Judgments Involving a Criminal Stalking Case. Law and Human Behavior. PMID 26237334 DOI: 10.1037/Lhb0000151  0.037
2002 Lane K, Lynch K, Mrenna S, Simmons EH. Resonant and nonresonant effects in photon-technipion production at lepton colliders Physical Review D. 66. DOI: 10.1103/Physrevd.66.015001  0.036
2003 McLellan AT, Gutman M, Lynch K, McKay JR, Ketterlinus R, Morgenstern J, Woolis D. One-year outcomes from the CASAWORKS for Families intervention for substance-abusing women on welfare. Evaluation Review. 27: 656-80. PMID 14650279 DOI: 10.1177/0193841X03259029  0.036
2003 Glaser K, Grundy E, Lynch K. Transitions to supported environments in England and Wales among elderly widowed and divorced women: the changing balance between co-residence with family and institutional care. Journal of Women & Aging. 15: 107-26; discussion 1. PMID 14604004 DOI: 10.1300/J074v15n02_07  0.035
2002 McCauley TR, Jee WH, Galloway MT, Lynch K, Jokl P. Grade 2C signal in the meniscus [correction of mensicus] on MR imaging of the knee. Ajr. American Journal of Roentgenology. 179: 645-8. PMID 12185036 DOI: 10.2214/ajr.179.3.1790645  0.034
2013 Wasarhaley NE, Golding JM, Lynch KR, Keller PS. The impact of abuse allegations in perceiving parricide in the courtroom Psychology, Crime and Law. 19: 783-799. DOI: 10.1080/1068316X.2012.684056  0.034
1991 Menard J, El Amrani AIK, Savoie F, Bouhnik J, Lynch KR, Peach MJ. Angiotensinogen: An attractive and underrated participant in hypertension and inflammation Hypertension. 18: 705-707. PMID 1937670  0.034
2021 Küçüktabak EB, Kim SJ, Wen Y, Lynch K, Pons JL. Human-machine-human interaction in motor control and rehabilitation: a review. Journal of Neuroengineering and Rehabilitation. 18: 183. PMID 34961530 DOI: 10.1186/s12984-021-00974-5  0.034
2009 Belenko S, Dugosh KL, Lynch K, Mericle AA, Pich M, Forman RF. Online illegal drug use information: an exploratory analysis of drug-related website viewing by adolescents. Journal of Health Communication. 14: 612-30. PMID 19851914 DOI: 10.1080/10810730903089622  0.034
2015 Golding JM, Wasarhaley NE, Lynch KR, Lippert A, Magyarics CL. Improving the Credibility of Child Sexual Assault Victims in Court: The Impact of a Sexual Assault Nurse Examiner. Behavioral Sciences & the Law. 33: 493-507. PMID 26294384 DOI: 10.1002/Bsl.2188  0.034
2009 Gariti P, Lynch K, Alterman A, Kampman K, Xie H, Varillo K. Comparing smoking treatment programs for lighter smokers with and without a history of heavier smoking. Journal of Substance Abuse Treatment. 37: 247-55. PMID 19339135 DOI: 10.1016/j.jsat.2009.01.006  0.034
2014 Denham JW, Nowitz M, Joseph D, Duchesne G, Spry NA, Lamb DS, Matthews J, Turner S, Atkinson C, Tai KH, Gogna NK, Kenny L, Diamond T, Smart R, Rowan D, ... ... Lynch K, et al. Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans-Tasman Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) randomized controlled trial for locally advanced prostate cancer. Bju International. 114: 344-53. PMID 24512527 DOI: 10.1111/bju.12497  0.033
2023 Lee CT, Palacios J, Richards D, Hanlon AK, Lynch K, Harty S, Claus N, Swords L, O'Keane V, Stephan KE, Gillan CM. The Precision in Psychiatry (PIP) study: Testing an internet-based methodology for accelerating research in treatment prediction and personalisation. Bmc Psychiatry. 23: 25. PMID 36627607 DOI: 10.1186/s12888-022-04462-5  0.032
1990 Lethbridge DJ, Tausch J, Lynch KR, Noyes DE. Second-step versus competence-based RN baccalaureate education in a rural setting. Nln Publications. 63-7. PMID 2235464  0.032
2015 Lynch KR, Logan TK. Risk Factors in Arrest of Rural and Urban Female Victims of Intimate Partner Violence. Violence and Victims. 30: 488-501. PMID 26118268 DOI: 10.1891/0886-6708.VV-D-14-00041  0.031
2023 Fox CA, Lee CT, Hanlon AK, Seow TXF, Lynch K, Harty S, Richards D, Palacios J, O'Keane V, Stephan KE, Gillan CM. An observational treatment study of metacognition in anxious-depression. Elife. 12. PMID 37818942 DOI: 10.7554/eLife.87193  0.03
2018 Justice AC, Smith RV, Tate JP, McGinnis K, Xu K, Becker WC, Lee KY, Lynch K, Sun N, Concato J, Fiellin DA, Zhao H, Gelernter J, Kranzler HR. AUDIT-C and ICD Codes as Phenotypes for Harmful Alcohol Use: Association with ADH1B Polymorphisms in Two U.S. Populations. Addiction (Abingdon, England). PMID 29972609 DOI: 10.1111/add.14374  0.03
2009 Rendall MS, Ekert-Jaffé O, Joshi H, Lynch K, Mougin R. UNIVERSAL VERSUS ECONOMICALLY POLARIZED CHANGE IN AGE AT FIRST BIRTH: A FRENCH-BRITISH COMPARISON. Population and Development Review. 35: 89-115. PMID 22740723 DOI: 10.1111/j.1728-4457.2009.00262.x  0.029
2015 Golding JM, Lynch KR, Wasarhaley NE, Keller PS. Courtroom Perceptions of Child Sexual Assault: The Impact of an Eyewitness Criminal Justice and Behavior. 42: 763-781. DOI: 10.1177/0093854814568552  0.029
2015 Renzetti CM, Lynch KR, DeWall CN. Ambivalent Sexism, Alcohol Use, and Intimate Partner Violence Perpetration. Journal of Interpersonal Violence. PMID 26354500 DOI: 10.1177/0886260515604412  0.028
2021 Straker RJ, Carr MJ, Sinnamon AJ, Shannon AB, Sun J, Landa K, Baecher KM, Wood C, Lynch K, Bartels HG, Panchaud R, Lowe MC, Slingluff CL, Jameson MJ, Tsai K, et al. Predictors of False Negative Sentinel Lymph Node Biopsy in Clinically Localized Merkel Cell Carcinoma. Annals of Surgical Oncology. PMID 33890195 DOI: 10.1245/s10434-021-10031-z  0.028
2005 Coviello DM, Zanis DA, Lynch K. Effectiveness of vocational problem-solving skills on motivation and job-seeking action steps. Substance Use & Misuse. 39: 2309-24. PMID 15603006 DOI: 10.1081/ja-200034625  0.028
1997 Lamb MA, Lynch KR. Collaborative practice in cancer education. Cancer Practice. 5: 122-3. PMID 9110650  0.026
2008 Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM, Lynch K, Vernon-Roberts B, Zannettino ACW. Long-term imatinib therapy promotes bone formation in CML patients Blood. 111: 2538-2547. DOI: 10.1182/blood-2007-07-104281  0.024
2013 Andreev VA, Banks TI, Carey RM, Case TA, Clayton SM, Crowe KM, Deutsch J, Egger J, Freedman SJ, Ganzha VA, Gorringe T, Gray FE, Hertzog DW, Hildebrandt M, Kammel P, ... ... Lynch KR, et al. Measurement of muon capture on the proton to 1% precision and determination of the pseudoscalar coupling gP. Physical Review Letters. 110: 012504. PMID 23383785 DOI: 10.1103/Physrevlett.110.012504  0.024
2006 Raphael B, Haims AH, Wu JS, Katz LD, White LM, Lynch K. MRI comparison of periprosthetic structures around zirconium knee prostheses and cobalt chrome prostheses American Journal of Roentgenology. 186: 1771-1777. PMID 16714672 DOI: 10.2214/AJR.05.1077  0.023
2011 Webber DM, Tishchenko V, Peng Q, Battu S, Carey RM, Chitwood DB, Crnkovic J, Debevec PT, Dhamija S, Earle W, Gafarov A, Giovanetti K, Gorringe TP, Gray FE, Hartwig Z, ... ... Lynch KR, et al. Publisher’s Note: Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant to Part-per-Million Precision [Phys. Rev. Lett.106, 041803 (2011)] Physical Review Letters. 106. DOI: 10.1103/Physrevlett.106.079901  0.023
2003 Skowronski DM, Buxton JA, Hestrin M, Keyes RD, Lynch K, Halperin SA. Carotid artery dissection as a possible severe complication of pertussis in an adult: clinical case report and review. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 36: e1-4. PMID 12491221 DOI: 10.1086/344776  0.022
2004 Polek C, Klemm P, Hardie T, Wheeler E, Birney M, Lynch K. Asian/Pacific Islander American women: age and death rates during hospitalization for breast cancer. Oncology Nursing Forum. 31: E69-74. PMID 15252439 DOI: 10.1188/04.Onf.E69-E74  0.022
2011 Witmer CM, Huang YS, Lynch K, Raffini LJ, Shah SS. Off-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study. The Journal of Pediatrics. 158: 820-825.e1. PMID 21146180 DOI: 10.1016/j.jpeds.2010.10.038  0.021
2015 Lynch KR, Logan TK. Police Officers' Attitudes and Challenges With Charging Stalking. Violence and Victims. PMID 26440289 DOI: 10.1891/0886-6708.VV-D-13-00085  0.021
2018 Ashford RD, Lynch K, Curtis B. Technology and Social Media Use Among Patients Enrolled in Outpatient Addiction Treatment Programs: Cross-Sectional Survey Study. Journal of Medical Internet Research. 20: e84. PMID 29510968 DOI: 10.2196/jmir.9172  0.021
2002 Lynch KR. Extended electroweak interactions and the muon gμ - 2 Physical Review D. 65. DOI: 10.1103/PhysRevD.65.053006  0.02
2013 Lynch KR, Schwerha DJ, Johanson GA. Development of a Weighted Heuristic for Website Evaluation for Older Adults International Journal of Human-Computer Interaction. 29: 404-418. DOI: 10.1080/10447318.2012.715277  0.019
2008 Tishchenko V, Battu S, Cheekatmalla S, Chitwood DB, Dhamija S, Gorringe TP, Gray F, Lynch KR, Logashenko I, Rath S, Webber DM. Data acquisition system for the MuLan muon lifetime experiment Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 592: 114-122. DOI: 10.1016/J.Nima.2008.03.121  0.019
2015 Lynch KR, Logan TK. "You Better Say Your Prayers and Get Ready": Guns Within the Context of Partner Abuse. Journal of Interpersonal Violence. PMID 26545394 DOI: 10.1177/0886260515613344  0.016
2023 Casalvera A, Goodwin M, Lynch K, Teferi M, Patel M, Grillon C, Ernst M, Balderston NL. Threat of shock increases distractor susceptibility during the short-term maintenance of visual information. Medrxiv : the Preprint Server For Health Sciences. PMID 38045307 DOI: 10.1101/2023.11.22.23298914  0.016
2009 Lynch KR. The MuLan Experiment: The Muon Lifetime at 1 part per million Nuclear Physics B - Proceedings Supplements. 189: 15-20. DOI: 10.1016/j.nuclphysbps.2009.03.004  0.015
2010 Smallwood S, Lynch K. An analysis of patient register data in the Longitudinal Study - what does it tell us about the quality of the data? Population Trends. 148-66. PMID 20927034 DOI: 10.1057/pt.2010.26  0.013
2005 Gray FE, Crowe KM, Lauss B, Carey RM, Earle W, Gafarov A, Graf B, Hance M, Hare M, Logashenko I, Lynch KR, Matus Y, Miller JP, -Roberts BL, Wasserman J, et al. Precision muon lifetime and capture experiments at PSI Nuclear Physics B - Proceedings Supplements. 149: 344-347. DOI: 10.1016/j.nuclphysbps.2005.05.063  0.011
2002 Brinkmann V, Lynch KR. Transplantation Current Opinion in Immunology. 14: 559-561. PMID 12183153 DOI: 10.1016/S0952-7915(02)00390-4  0.011
2021 May A, Lynch K. Impact on emergency department analgosedation practices through a pharmacist-driven protocol. The American Journal of Emergency Medicine. PMID 34183198 DOI: 10.1016/j.ajem.2021.06.037  0.01
2014 Lynch KR, Golding JM, Wasarhaley NE. Perceptions of adult parricide in a case involving repressed sexual abuse American Journal of Forensic Psychology. 32: 19-38.  0.01
2013 Delgado-Fernandez I, Jackson DWT, Cooper JAG, Baas ACW, Beyers JHM, Lynch K. Field characterization of three-dimensional lee-side airflow patterns under offshore winds at a beach-dune system Journal of Geophysical Research: Earth Surface. 118: 706-721. DOI: 10.1002/jgrf.20036  0.01
2012 Tishchenko V, Battu S, Carey RM, Chitwood DB, Crnkovic J, Debevec PT, Dhamija S, Earle W, Gafarov A, Giovanetti K, Gorringe TP, Gray FE, Hartwig Z, Hertzog DW, Johnson B, ... ... Lynch KR, et al. Precision measurement of the positive muon lifetime by the MuLan collaboration Nuclear Physics B - Proceedings Supplements. 225: 232-235. DOI: 10.1016/j.nuclphysbps.2012.02.048  0.01
2011 Akinwale B, Lynch K, Wiggins R, Harding S, Bartley M, Blane D. Work, permanent sickness and mortality risk: a prospective cohort study of England and Wales, 1971-2006. Journal of Epidemiology and Community Health. 65: 786-92. PMID 20522433 DOI: 10.1136/jech.2009.099325  0.01
2011 Jackson DWT, Beyers JHM, Lynch K, Cooper JAG, Baas ACW, Delgado-Fernandez I. Investigation of three-dimensional wind flow behaviour over coastal dune morphology under offshore winds using computational fluid dynamics (CFD) and ultrasonic anemometry Earth Surface Processes and Landforms. 36: 1113-1124. DOI: 10.1002/esp.2139  0.01
2006 Lynch KR. MuLan: Towards a 1 ppm muon lifetime measurement Aip Conference Proceedings. 870: 333-335. DOI: 10.1063/1.2402647  0.01
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