Thomas H. Graham - Related publications

Affiliations: 
Merck Research Laboratories - Boston, Boston, MA 
Area:
Medicinal Chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Sun Z, Yang S, Xu C, Yi F, Cao L, Tian Y, Lin J, Xu X. Concise total synthesis of (+)-Zeylenone with antitumor activity and the structure-activity relationship of its derivatives. Bioorganic Chemistry. 116: 105333. PMID 34537516 DOI: 10.1016/j.bioorg.2021.105333   
2021 Ramos-Orea A, Ramírez-Apan T, Chávez-Santos RM, Aguayo-Ortiz R, Espitia C, Silva Miranda M, Torres-Ochoa RO, Martínez R. Total syntheses and antiproliferative activities of prenostodione and its analogues. Organic & Biomolecular Chemistry. 19: 8272-8280. PMID 34518856 DOI: 10.1039/d1ob00897h   
2021 Kunwar S, Hwang SY, Katila P, Seo M, Man Kadayat T, Kwon Y, Lee ES. 4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships. Bioorganic Chemistry. 116: 105349. PMID 34536927 DOI: 10.1016/j.bioorg.2021.105349   
2021 Pluskota R, Jaroch K, Kośliński P, Ziomkowska B, Lewińska A, Kruszewski S, Bojko B, Koba M. Selected Drug-Likeness Properties of 2-Arylidene-indan-1,3-dione Derivatives-Chemical Compounds with Potential Anti-Cancer Activity. Molecules (Basel, Switzerland). 26. PMID 34500689 DOI: 10.3390/molecules26175256   
2021 Xu Y, Xie J, Wu WC, Chen BT, Zhang SQ, Wang R, Huang J, Guo ZK. Discovery of an unprecedented benz[α]anthraquinone-type heterodimer from a rare actinomycete Amycolatopsis sp. HCa1. Fitoterapia. 105039. PMID 34592372 DOI: 10.1016/j.fitote.2021.105039   
2021 Thirupataiah B, Mounika G, Sujeevan Reddy G, Sandeep Kumar J, Kapavarapu R, Medishetti R, Mudgal J, Mathew JE, Shenoy GG, Mallikarjuna Rao C, Chatti K, V L Parsa K, Pal M. CuCl-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors. Bioorganic Chemistry. 115: 105265. PMID 34426160 DOI: 10.1016/j.bioorg.2021.105265   
2021 Hu M, Wu Z, Yao B, Li J, Wu W, Jiang H. Pd-Catalyzed Sequential Formation of C-C Bonds: A New Strategy for the Synthesis of ()-α,β-Unsaturated Carbonyl Compounds from Sulfoxonium Ylides and 1-Iodo-2-((2-methylallyl)oxy)benzene Compounds. The Journal of Organic Chemistry. 86: 11545-11556. PMID 34479410 DOI: 10.1021/acs.joc.1c01119   
2021 Miao SX, Wan LX, He ZX, Zhou XL, Li X, Gao F. Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of -Aryl Huperzine A Analogues. Journal of Natural Products. 84: 2374-2379. PMID 34445873 DOI: 10.1021/acs.jnatprod.1c00600   
2021 Jeon YK, Kim WS. 1,3-Aza-Brook Rearrangement of Aniline Derivatives: In Situ Generation of 3-Aminoaryne via 1,3-C-(sp)-to-N Silyl Migration. Organic Letters. PMID 34553933 DOI: 10.1021/acs.orglett.1c02751   
2021 Ganaie BA, Shahid M, Rashid A, Ara T, Ahmad Banday J, Malik F, Bhat BA. Platanic Acid-Aryl Enones as Potential Anticancer Compounds: Synthesis and Biological Profiling against Breast, Prostate and Lung Cancer Cell Lines. Chemistry & Biodiversity. e2100292. PMID 34467653 DOI: 10.1002/cbdv.202100292   
2021 Thirupataiah B, Reddy GS, Mounika G, Kumar JS, Hossain KA, Mudgal J, Mathew JE, Shenoy GG, Rajadurai M, Parsa KVL, Pal M. Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation. Chemical Communications (Cambridge, England). PMID 34515287 DOI: 10.1039/d1cc04140a   
2021 Fu L, Dai DC, Yang R, Chen GY, Zheng CJ, Song XM, Zhou XM. Two novel aporphine-derived alkaloids from the stems of Fissistigma glaucescens. Fitoterapia. 105036. PMID 34536535 DOI: 10.1016/j.fitote.2021.105036   
2021 Ferla S, Varricchio C, Knight W, Ho PK, Saporito F, Tropea B, Fagan G, Flude BM, Bevilacqua F, Santos-Ferreira N, Van Dycke J, Neyts J, Brancale A, Rocha-Pereira J, Bassetto M. Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections. Microorganisms. 9. PMID 34576691 DOI: 10.3390/microorganisms9091795   
2021 Saroha B, Kumar G, Kumar R, Kumari M, Kumar S. A minireview of 1,2,3-Triazole hybrids with O-Heterocycles as leads in medicinal chemistry. Chemical Biology & Drug Design. PMID 34592059 DOI: 10.1111/cbdd.13966   
2021 Dai M, Wang YC, Cui C. Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A. Angewandte Chemie (International Ed. in English). PMID 34405497 DOI: 10.1002/anie.202109625   
2021 Yuan X, Yu X, He K, Zhang R, Xiao W, Lin J, Zhan Z, Cheng X, Shao Z, Jin Y. Dual C(sp)-H Functionalization of Cyclic Ethers via Singlet Oxygen-Mediated Ring Opening and Ring Closing. Organic Letters. PMID 34633191 DOI: 10.1021/acs.orglett.1c03008   
2021 Kazakova O, Rubanik L, Lobov A, Poleshchuk N, Baikova I, Kapustina Y, Petrova A, Korzun T, Lopatina T, Fedorova A, Rybalova T, Polovianenko D, Mioc M, Șoica C. Synthesis of erythrodiol C-ring derivatives and their activity against Chlamydia trachomatis. Steroids. 175: 108912. PMID 34480919 DOI: 10.1016/j.steroids.2021.108912   
2021 Tahir T, Ashfaq M, Saleem M, Rafiq M, Shahzad MI, Kotwica-Mojzych K, Mojzych M. Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives. Molecules (Basel, Switzerland). 26. PMID 34443460 DOI: 10.3390/molecules26164872   
2021 Wu Y, Wen K, Chen J, Shi J, Yao X, Tang X. Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds. Organic Letters. PMID 34612042 DOI: 10.1021/acs.orglett.1c02897   
2021 Silverberg LJ, Mal TK, Pacheco CN, Povelones ML, Malfara MF, Lagalante AF, Olsen MA, Yennawar HP, Sobhi HF, Baney KR, Bozeman RL, Eroh CS, Fleming MJ, Garcia TL, Gregory CL, et al. T3P-Promoted Synthesis of a Series of 2-Aryl-3-phenyl-2,3-dihydro-4-pyrido[3,2-][1,3]thiazin-4-ones and Their Activity against the Kinetoplastid Parasite . Molecules (Basel, Switzerland). 26. PMID 34684680 DOI: 10.3390/molecules26206099   
2021 Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. 8-Amino-6-Methoxyquinoline-Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity. Molecules (Basel, Switzerland). 26. PMID 34577001 DOI: 10.3390/molecules26185530   
2021 Zhou N, Zhao J, Sun C, Lai Y, Ruan Z, Feng P. Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles. The Journal of Organic Chemistry. PMID 34520191 DOI: 10.1021/acs.joc.1c01271   
2021 Chu HW, Sethy B, Hsieh PW, Horng JT. Identification of Potential Drug Targets of Broad-Spectrum Inhibitors with a Michael Acceptor Moiety Using Shotgun Proteomics. Viruses. 13. PMID 34578337 DOI: 10.3390/v13091756   
2021 Damiens A, Dascalu AE, Alebrahim MT, Furman C, Lipka E, Ghinet A, Hilbert JL, Siah A, Billamboz M. γ-Lactam-based antifungal compounds against the wheat pathogen Zymoseptoria tritici. Chemistry & Biodiversity. PMID 34460992 DOI: 10.1002/cbdv.202100224   
2021 Kang QQ, Zhang WK, Ge GP, Zheng H, Wei WT. The construction of benzimidazo[2,1-]isoquinolin-6(5)-ones from -methacryloyl-2-phenylbenzoimidazoles through radical strategies. Organic & Biomolecular Chemistry. PMID 34610071 DOI: 10.1039/d1ob01465j   
2021 Sun CP, Yi J, Wei F, Lv X, Deng S, Zhang BJ, Zhao WY, Ma XC. UV-light-driven photooxidation of harmaline catalyzed by riboflavin: Product characterization and mechanisms. Fitoterapia. 105054. PMID 34626737 DOI: 10.1016/j.fitote.2021.105054   
2021 Yadagiri D, Anbarasan P. Catalytic Functionalization of Metallocarbenes Derived from α-Diazocarbonyl Compounds and Their Precursors. Chemical Record (New York, N.Y.). PMID 34448345 DOI: 10.1002/tcr.202100167   
2021 Ren J, Du FH, Jia MC, Hu ZN, Chen Z, Zhang C. Ring Expansion Fluorination of Unactivated Cyclopropanes Mediated by a New Monofluoroiodane(III) Reagent. Angewandte Chemie (International Ed. in English). PMID 34523779 DOI: 10.1002/anie.202108589   
2021 Alam RM, Keating JJ. Regioselective -alkylation of the 1-indazole scaffold; ring substituent and -alkylating reagent effects on regioisomeric distribution. Beilstein Journal of Organic Chemistry. 17: 1939-1951. PMID 34386104 DOI: 10.3762/bjoc.17.127   
2021 Zhang T, Wang K, Ke Y, Tang Y, Liu L, Huang T, Li C, Tang Z, Chen T. Transition-metal-free and base promoted C-C bond formation C-N bond cleavage of organoammonium salts. Organic & Biomolecular Chemistry. PMID 34492680 DOI: 10.1039/d1ob01468d   
2021 Kirschner S, Yuan K, Ingleson MJ. Haloboration: scope, mechanism and utility. New Journal of Chemistry = Nouveau Journal De Chimie. 45: 14855-14868. PMID 34483652 DOI: 10.1039/d0nj02908d   
2021 Munikishore R, Wang LL, Zhang S, Zhao QS, Zuo Z. An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94. Bioorganic Chemistry. 116: 105317. PMID 34488126 DOI: 10.1016/j.bioorg.2021.105317   
2021 Yin C, Zhong T, Zheng X, Li L, Zhou J, Yu C. Direct synthesis of indazole derivatives Rh(III)-catalyzed C-H activation of phthalazinones and allenes. Organic & Biomolecular Chemistry. 19: 7701-7705. PMID 34524333 DOI: 10.1039/d1ob01458g   
2021 Fan D, Wang B, Stelitano G, Savková K, Shi R, Huszár S, Han Q, Mikušová K, Chiarelli LR, Lu Y, Qiao C. Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents. Journal of Medicinal Chemistry. PMID 34609861 DOI: 10.1021/acs.jmedchem.1c01049   
2021 Yuan YC, Liu TZ, Zhao BX. Metal-Free Catalyzed Synthesis of Fluorescent Indolizine Derivatives. The Journal of Organic Chemistry. PMID 34459206 DOI: 10.1021/acs.joc.1c01292   
2021 Klumthong K, Chalermsub P, Sopha P, Ruchirawat S, Ploypradith P. An Expeditious Modular Hybrid Strategy for the Diversity-Oriented Synthesis of Lamellarins/Azalamellarins with Anticancer Cytotoxicity. The Journal of Organic Chemistry. PMID 34436897 DOI: 10.1021/acs.joc.1c01639   
2021 Chen Y, Wen S, Tian Q, Zhang Y, Cheng G. Transition Metal-Free C-H Thiolation via Sulfonium Salts Using β-Sulfinylesters as the Sulfur Source. Organic Letters. PMID 34579530 DOI: 10.1021/acs.orglett.1c02912   
2021 Ghosh P, Das S. The C-H functionalization of -alkoxycarbamoyl indoles by transition metal catalysis. Organic & Biomolecular Chemistry. PMID 34490862 DOI: 10.1039/d1ob01121a   
2021 Guo X, Shao BR, Jiang WF, Shi L. The Photocatalyst-Free Cross-Dehydrogenative Coupling Reaction Enabled by Visible-Light Direct Excitation of Substrate. The Journal of Organic Chemistry. PMID 34694134 DOI: 10.1021/acs.joc.1c01775   
2021 Tarigopula C, Manojveer S, Balamurugan R. Synthesis of Highly Substituted Biaryls by the Construction of a Benzene Ring via Formed Acetals. The Journal of Organic Chemistry. 86: 11871-11883. PMID 34425048 DOI: 10.1021/acs.joc.1c01277   
2021 Poonia N, Kumar A, Kumar V, Yadav M, Lal K. Recent progress on 1H-1,2,3-triazoles as potential antifungal agents. Current Topics in Medicinal Chemistry. PMID 34517801 DOI: 10.2174/1568026621666210913122828   
2021 Bera S, Kabadwal LM, Banerjee D. Recent advances in transition metal-catalyzed (1,) annulation using (de)-hydrogenative coupling with alcohols. Chemical Communications (Cambridge, England). PMID 34486592 DOI: 10.1039/d1cc03404a   
2021 O'Hagan D, Clark J, Neyyappadath RM, Yu C, Slawin AMZ, Cordes DB. Janus all-cis 2,3,4,5,6-pentafluorocyclohexyl building blocks applied to medicinal chemistry and bioactives discovery chemistry'. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34486192 DOI: 10.1002/chem.202102819   
2021 Shelke YG, Hande PE, Gharpure SJ. Recent advances in the synthesis of pyrrolo[1,2-]indoles and their derivatives. Organic & Biomolecular Chemistry. 19: 7544-7574. PMID 34524330 DOI: 10.1039/d1ob01103k   
2021 Khattab RR, Hassan AA, A Osman DA, Abdel-Megeid FM, Awad HM, Nossier ES, El-Sayed WA. Synthesis, anticancer activity and molecular docking of new triazolo[4,5-]pyrimidines based thienopyrimidine system and their derived -glycosides and thioglycosides. Nucleosides, Nucleotides & Nucleic Acids. 40: 1090-1113. PMID 34496727 DOI: 10.1080/15257770.2021.1975297   
2021 Ren J, Ding S, Li X, Bi R, Zhao Q. An Approach for the Synthesis of Pyrazolo[1,5-]pyrimidines via Cu(II)-Catalyzed [3+3] Annulation of Saturated Ketones with Aminopyrazoles. The Journal of Organic Chemistry. PMID 34464147 DOI: 10.1021/acs.joc.1c01343   
2021 Wang X, Hu N, Kong W, Song B, Li S. Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads. European Journal of Medicinal Chemistry. 227: 113912. PMID 34653771 DOI: 10.1016/j.ejmech.2021.113912   
2021 Chen G, Wang Y, Zhao J, Zhang X, Fan X. Synthesis of Hydroxysuccinimide Substituted Indolin-3-ones via One-Pot Cascade Reaction of -Alkynylnitrobenzenes with Maleimides under Au(III)-Cu(II) Relay/Synergetic Catalysis. The Journal of Organic Chemistry. PMID 34590848 DOI: 10.1021/acs.joc.1c01485   
2021 Hou BL, Li LX, Li CC. Synthesis of the Bridged [5-7-7] Tricyclic Core of Eurifoloid A. Organic Letters. PMID 34554764 DOI: 10.1021/acs.orglett.1c02784   
2021 Mao Y, Mao H, Xu J, Liu T, Liu B, Tan Q, Ding CH, Xu B. Synthesis of Poly-substituted Pyridines via Noble-Metal-Free Cycloaddition of Ketones and Imines. Chemistry, An Asian Journal. PMID 34626095 DOI: 10.1002/asia.202100983