Marta Filizola - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hu X, Provasi D, Ramsey S, Filizola M. Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation. Biophysical Journal. PMID 31676132 DOI: 10.1016/j.bpj.2019.10.007  1
2019 Hu X, Wang Y, Hunkele A, Provasi D, Pasternak GW, Filizola M. Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis. Plos Computational Biology. 15: e1006689. PMID 30677023 DOI: 10.1371/journal.pcbi.1006689  1
2018 Meral D, Provasi D, Filizola M. An efficient strategy to estimate thermodynamics and kinetics of G protein-coupled receptor activation using metadynamics and maximum caliber. The Journal of Chemical Physics. 149: 224101. PMID 30553249 DOI: 10.1063/1.5060960  1
2018 Walsh SM, Mathiasen S, Christensen SM, Fay JF, King C, Provasi D, Borrero E, Rasmussen SGF, Fung JJ, Filizola M, Hristova K, Kobilka B, Farrens DL, Stamou D. Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs. Biophysical Journal. 115: 300-312. PMID 30021106 DOI: 10.1016/j.bpj.2018.05.036  1
2018 Meral D, Provasi D, Prada-Gracia D, Möller J, Marino K, Lohse MJ, Filizola M. Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations. Scientific Reports. 8: 7705. PMID 29769636 DOI: 10.1038/s41598-018-26070-8  1
2018 Marino KA, Filizola M. Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations. Methods in Molecular Biology (Clifton, N.J.). 1705: 351-364. PMID 29188572 DOI: 10.1007/978-1-4939-7465-8_17  0.72
2017 Zafar H, Shang Y, Li J, David GA, Fernandez JP, Molina H, Filizola M, Coller BS. αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible. Blood Advances. 1: 417-428. PMID 29296957 DOI: 10.1182/bloodadvances.2017004689  1
2017 Yano H, Provasi D, Cai NS, Filizola M, Ferre S, Javitch JA. Development of novel biosensors to study receptor-mediated activation of Gs and Golf. The Journal of Biological Chemistry. PMID 29042444 DOI: 10.1074/jbc.M117.800698  1
2017 Kapoor A, Martinez-Rosell G, Provasi D, de Fabritiis G, Filizola M. Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity. Scientific Reports. 7: 11255. PMID 28900175 DOI: 10.1038/s41598-017-11483-8  1
2017 Marino KA, Shang Y, Filizola M. Insights into the Function of Opioid Receptors from Molecular Dynamics Simulations of Available Crystal Structures. British Journal of Pharmacology. PMID 28266020 DOI: 10.1111/bph.13774  1
2016 Marino KA, Prada-Gracia D, Provasi D, Filizola M. Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model. Plos Computational Biology. 12: e1005240. PMID 27959924 DOI: 10.1371/journal.pcbi.1005240  1
2016 Crowley RS, Riley AP, Sherwood AM, Groer CE, Shivaperumal N, Biscaia M, Paton K, Schneider S, Provasi D, Kivell BM, Filizola M, Prisinzano TE. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of Medicinal Chemistry. PMID 27958743 DOI: 10.1021/acs.jmedchem.6b01235  1
2016 Schneider S, Provasi D, Filizola M. How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State that Selectively Triggers G Protein-Signaling Pathways. Biochemistry. PMID 27778501 DOI: 10.1021/acs.biochem.6b00948  1
2016 Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Science Signaling. 9: ra55. PMID 27245612 DOI: 10.1126/scisignal.aac8035  1
2016 Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. Journal of the American Chemical Society. PMID 27192616 DOI: 10.1021/jacs.6b00360  1
2016 Shang Y, Yeatman HR, Provasi D, Alt A, Christopoulos A, Canals M, Filizola M. Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors. Acs Chemical Biology. PMID 26841170 DOI: 10.1021/acschembio.5b00712  1
2015 Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. Journal of Chemical Information and Modeling. PMID 26347990 DOI: 10.1021/acs.jcim.5b00388  1
2015 Shang Y, Filizola M. Opioid receptors: Structural and mechanistic insights into pharmacology and signaling. European Journal of Pharmacology. PMID 25981301 DOI: 10.1016/j.ejphar.2015.05.012  1
2015 Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, et al. Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor. Journal of Medicinal Chemistry. 58: 4220-9. PMID 25901762 DOI: 10.1021/acs.jmedchem.5b00007  1
2015 Buitrago L, Rendon A, Liang Y, Simeoni I, Negri A, Filizola M, Ouwehand WH, Coller BS. αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia. Proceedings of the National Academy of Sciences of the United States of America. 112: E1898-907. PMID 25827233 DOI: 10.1073/pnas.1422238112  1
2015 Provasi D, Boz MB, Johnston JM, Filizola M. Preferred supramolecular organization and dimer interfaces of opioid receptors from simulated self-association. Plos Computational Biology. 11: e1004148. PMID 25822938 DOI: 10.1371/journal.pcbi.1004148  1
2014 Li J, Vootukuri S, Shang Y, Negri A, Jiang JK, Nedelman M, Diacovo TG, Filizola M, Thomas CJ, Coller BS. RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2321-9. PMID 25147334 DOI: 10.1161/ATVBAHA.114.303724  1
2014 Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M. Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry. 53: 5140-9. PMID 25073009 DOI: 10.1021/bi5006915  1
2014 Provasi D, Negri A, Coller BS, Filizola M. Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations. Proteins. 82: 3231-40. PMID 24677266 DOI: 10.1002/prot.24540  1
2014 Johnston JM, Filizola M. Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors. Plos One. 9: e90694. PMID 24651466 DOI: 10.1371/journal.pone.0090694  0.72
2014 Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X. G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacological Reviews. 66: 413-34. PMID 24515647 DOI: 10.1124/pr.113.008052  1
2014 Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G, Choi WS, Volpi E, Fernandez J, Babayeva M, ... ... Filizola M, et al. A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor. Bioorganic & Medicinal Chemistry Letters. 24: 1148-53. PMID 24461295 DOI: 10.1016/j.bmcl.2013.12.122  1
2014 Johnston JM, Filizola M. Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods. Advances in Experimental Medicine and Biology. 796: 95-125. PMID 24158803 DOI: 10.1007/978-94-007-7423-0_6  0.72
2014 Scarabelli G, Provasi D, Negri A, Filizola M. Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles. Biopolymers. 101: 21-7. PMID 23564013 DOI: 10.1002/bip.22251  1
2013 Mondal S, Johnston JM, Wang H, Khelashvili G, Filizola M, Weinstein H. Membrane driven spatial organization of GPCRs. Scientific Reports. 3: 2909. PMID 24105260 DOI: 10.1038/srep02909  1
2013 Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA. Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proceedings of the National Academy of Sciences of the United States of America. 110: 12072-7. PMID 23818586 DOI: 10.1073/pnas.1222044110  1
2013 Negri A, Rives ML, Caspers MJ, Prisinzano TE, Javitch JA, Filizola M. Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. Journal of Chemical Information and Modeling. 53: 521-6. PMID 23461591 DOI: 10.1021/ci400019t  1
2013 Coudray N, Valvo S, Hu M, Lasala R, Kim C, Vink M, Zhou M, Provasi D, Filizola M, Tao J, Fang J, Penczek PA, Ubarretxena-Belandia I, Stokes DL. Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 110: 2140-5. PMID 23341604 DOI: 10.1073/pnas.1215455110  1
2012 Johnston JM, Wang H, Provasi D, Filizola M. Assessing the relative stability of dimer interfaces in g protein-coupled receptors. Plos Computational Biology. 8: e1002649. PMID 22916005 DOI: 10.1371/journal.pcbi.1002649  1
2012 Negri A, Li J, Naini S, Coller BS, Filizola M. Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand. Journal of Computer-Aided Molecular Design. 26: 1005-15. PMID 22893377 DOI: 10.1007/s10822-012-9594-6  1
2012 Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, et al. Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Science Translational Medicine. 4: 125ra32. PMID 22422993 DOI: 10.1126/scitranslmed.3003576  1
2011 Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, ... ... Filizola M, et al. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. 147: 1011-23. PMID 22118459 DOI: 10.1016/j.cell.2011.09.055  1
2011 Provasi D, Artacho MC, Negri A, Mobarec JC, Filizola M. Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. Plos Computational Biology. 7: e1002193. PMID 22022248 DOI: 10.1371/journal.pcbi.1002193  1
2011 Johnston JM, Filizola M. Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors. Current Opinion in Structural Biology. 21: 552-8. PMID 21764295 DOI: 10.1016/j.sbi.2011.06.008  0.72
2011 Wang H, Barreyro L, Provasi D, Djemil I, Torres-Arancivia C, Filizola M, Ubarretxena-Belandia I. Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease. Journal of Molecular Biology. 408: 879-95. PMID 21440556 DOI: 10.1016/j.jmb.2011.03.028  1
2011 Golebiewska U, Johnston JM, Devi L, Filizola M, Scarlata S. Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors. Biochemistry. 50: 2829-37. PMID 21361347 DOI: 10.1021/bi101701x  0.72
2011 Johnston JM, Aburi M, Provasi D, Bortolato A, Urizar E, Lambert NA, Javitch JA, Filizola M. Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry. 50: 1682-90. PMID 21261298 DOI: 10.1021/bi101474v  1
2010 Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood. 116: 5050-9. PMID 20679525 DOI: 10.1182/blood-2010-04-281154  1
2010 Provasi D, Johnston JM, Filizola M. Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix. Biochemistry. 49: 6771-6. PMID 20617813 DOI: 10.1021/bi100686t  1
2010 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, ... ... Filizola M, et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 26: 1804-5. PMID 20501551 DOI: 10.1093/bioinformatics/btq264  1
2010 Provasi D, Filizola M. Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics. Biophysical Journal. 98: 2347-55. PMID 20483344 DOI: 10.1016/j.bpj.2010.01.047  1
2010 Blue R, Li J, Steinberger J, Murcia M, Filizola M, Coller BS. Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. The Journal of Biological Chemistry. 285: 17604-13. PMID 20363746 DOI: 10.1074/jbc.M110.107763  1
2009 Provasi D, Bortolato A, Filizola M. Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. Biochemistry. 48: 10020-9. PMID 19785461 DOI: 10.1021/bi901494n  1
2009 Mobarec JC, Sanchez R, Filizola M. Modern homology modeling of G-protein coupled receptors: which structural template to use? Journal of Medicinal Chemistry. 52: 5207-16. PMID 19627087 DOI: 10.1021/jm9005252  1
2009 Provasi D, Murcia M, Coller BS, Filizola M. Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins. 77: 477-89. PMID 19455709 DOI: 10.1002/prot.22463  1
2009 Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 114: 195-201. PMID 19414864 DOI: 10.1182/blood-2008-08-169243  1
2008 Mobarec JC, Filizola M. Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. Expert Opinion On Drug Discovery. 3: 343-355. PMID 19672320 DOI: 10.1517/17460441.3.3.343  1
2008 Guo W, Urizar E, Kralikova M, Mobarec JC, Shi L, Filizola M, Javitch JA. Dopamine D2 receptors form higher order oligomers at physiological expression levels. The Embo Journal. 27: 2293-304. PMID 18668123 DOI: 10.1038/emboj.2008.153  1
2008 González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, López-Giménez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 452: 93-7. PMID 18297054 DOI: 10.1038/nature06612  1
2008 Taylor MS, Fung HK, Rajgaria R, Filizola M, Weinstein H, Floudas CA. Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophysical Journal. 94: 2470-81. PMID 18178645 DOI: 10.1529/biophysj.107.117622  1
2008 Murcia M, Jirouskova M, Li J, Coller BS, Filizola M. Functional and computational studies of the ligand-associated metal binding site of beta3 integrins. Proteins. 71: 1779-91. PMID 18175315 DOI: 10.1002/prot.21859  1
2008 Niv MY, Filizola M. Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis. Proteins. 71: 575-86. PMID 17963239 DOI: 10.1002/prot.21787  1
2007 Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. Bmc Bioinformatics. 8: 177. PMID 17537266 DOI: 10.1186/1471-2105-8-177  1
2007 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/pr.59.1.5  1
2006 Niv MY, Skrabanek L, Filizola M, Weinstein H. Modeling activated states of GPCRs: the rhodopsin template. Journal of Computer-Aided Molecular Design. 20: 437-48. PMID 17103019 DOI: 10.1007/s10822-006-9061-3  1
2006 Filizola M, Wang SX, Weinstein H. Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. Journal of Computer-Aided Molecular Design. 20: 405-16. PMID 17089205 DOI: 10.1007/s10822-006-9053-3  1
2005 Guo W, Shi L, Filizola M, Weinstein H, Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 17495-500. PMID 16301531 DOI: 10.1073/pnas.0508950102  1
2005 Filizola M, Weinstein H. The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design. Current Opinion in Drug Discovery & Development. 8: 577-84. PMID 16159019  1
2005 Filizola M, Weinstein H. The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics. The Febs Journal. 272: 2926-38. PMID 15955053 DOI: 10.1111/j.1742-4658.2005.04730.x  1
2004 Filizola M, Hassan SA, Artoni A, Coller BS, Weinstein H. Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. The Journal of Biological Chemistry. 279: 24624-30. PMID 15056669 DOI: 10.1074/jbc.M400243200  1
2002 Filizola M, Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers. 66: 317-25. PMID 12539260 DOI: 10.1002/bip.10311  1
2002 Filizola M, Olmea O, Weinstein H. Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Engineering. 15: 881-5. PMID 12538907 DOI: 10.1093/protein/15.11.881  1
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