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Francis J. Castellino - Publications

Affiliations: 
Chemistry and Biochemistry University of Notre Dame, Notre Dame, IN, United States 
Area:
blood coagulation and blood clot dissolution
Website:
http://chemistry.nd.edu/faculty/detail/fcastell/
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331 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gladysheva IP, Sullivan RD, Saleem S, Castellino FJ, Ploplis VA, Reed GL. Coagulation factor XII contributes to renin activation, heart failure progression, and mortality. Biorxiv : the Preprint Server For Biology. PMID 39314400 DOI: 10.1101/2024.09.06.611753  0.479
2024 Marrufo AM, Molina JJ, Gager C, Andersen MJ, LaBella AA, Lucas ER, Wongso E, Urmi T, Arias-Parbul K, Webster R, Stuckey PV, Kohler KN, Donahue D, Ploplis VA, Flick MJ, ... Castellino FJ, et al. The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI. Biorxiv : the Preprint Server For Biology. PMID 39071295 DOI: 10.1101/2024.07.16.603761  0.507
2024 Brito-Robinson T, Ayinuola YA, Ploplis VA, Castellino FJ. Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease. Frontiers in Cardiovascular Medicine. 11: 1406953. PMID 38984351 DOI: 10.3389/fcvm.2024.1406953  0.482
2024 Molina JJ, Kohler KN, Gager C, Andersen MJ, Wongso E, Lucas ER, Paik A, Xu W, Donahue DL, Bergeron K, Klim A, Caparon MG, Hultgren SJ, Desai A, Ploplis VA, ... ... Castellino FJ, et al. Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Nature Communications. 15: 2704. PMID 38538626 DOI: 10.1038/s41467-024-46974-6  0.48
2024 Olesk J, Donahue D, Ross J, Sheehan C, Bennett Z, Armknecht K, Kudary C, Hopf J, Ploplis VA, Castellino FJ, Lee SW, Nallathamby PD. Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action against in murine wound infection models. Nanoscale Advances. 6: 1145-1162. PMID 38356633 DOI: 10.1039/d3na00620d  0.492
2023 Molina JJ, Kohler KN, Gager C, Andersen MJ, Wongso E, Lucas ER, Paik A, Xu W, Donahue DL, Bergeron K, Klim A, Caparon MG, Hultgren SJ, Desai A, Ploplis VA, ... ... Castellino FJ, et al. Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Research Square. PMID 37790429 DOI: 10.21203/rs.3.rs-3263501/v1  0.479
2023 Ranasinghe ADCU, Holohan M, Borger KM, Donahue DL, Kuc RD, Gerig M, Kim A, Ploplis VA, Castellino FJ, Schwarz MA. Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension. Circulation Research. PMID 37698017 DOI: 10.1161/CIRCRESAHA.123.322740  0.458
2023 Ayinuola YA, Donahue DL, Charles J, Liang Z, Castellino FJ, Ploplis VA. Generation and Characterization of a Plasminogen-Binding Group A Streptococcal M-Protein/Streptokinase-Sensitive Mouse Line. Journal of Thrombosis and Haemostasis : Jth. PMID 36914052 DOI: 10.1016/j.jtha.2023.02.028  0.536
2022 Charles J, McCann N, Ploplis VA, Castellino FJ. Spike protein receptor-binding domains from SARS-CoV-2 variants of interest bind human ACE2 more tightly than the prototype spike protein. Biochemical and Biophysical Research Communications. 641: 61-66. PMID 36525925 DOI: 10.1016/j.bbrc.2022.12.011  0.523
2022 Hammers DE, Donahue DL, Tucker ZD, Ashfeld BL, Ploplis VA, Castellino FJ, Lee SW. Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection. Frontiers in Cellular and Infection Microbiology. 12: 1002230. PMID 36389147 DOI: 10.3389/fcimb.2022.1002230  0.526
2022 Ayinuola YA, Tjia-Fleck S, Readnour BM, Liang Z, Ayinuola O, Paul LN, Lee SW, Fischetti VA, Ploplis VA, Castellino FJ. Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in . Frontiers in Microbiology. 13: 905670. PMID 35685926 DOI: 10.3389/fmicb.2022.905670  0.558
2022 Readnour BM, Ayinuola YA, Russo BT, Liang Z, Lee SW, Ploplis VA, Fischetti VA, Castellino FJ. Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation. The Journal of Biological Chemistry. 101940. PMID 35430253 DOI: 10.1016/j.jbc.2022.101940  0.55
2021 Ayinuola O, Ayinuola YA, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers. Microbiologyopen. 10: e1252. PMID 34964287 DOI: 10.1002/mbo3.1252  0.507
2021 Iwaki T, Arakawa T, Sandoval-Cooper MJ, Smith DL, Donahue D, Ploplis VA, Umemura K, Castellino FJ. Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia. Biomedicines. 9. PMID 34944648 DOI: 10.3390/biomedicines9121832  0.523
2021 Vu HM, Hammers DE, Liang Z, Nguyen GL, Benz ME, Moran TE, Higashi DL, Park CJ, Ayinuola YA, Donahue DL, Flores-Mireles AL, Ploplis VA, Castellino FJ, Lee SW. Group A Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution. Frontiers in Cardiovascular Medicine. 8: 667554. PMID 34179133 DOI: 10.3389/fcvm.2021.667554  0.508
2020 Ayinuola YA, Brito-Robinson T, Ayinuola O, Beck JE, Cruz-Topete D, Lee SW, Ploplis VA, Castellino FJ. Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence. The Journal of Biological Chemistry. PMID 33208461 DOI: 10.1074/jbc.RA120.016262  0.772
2020 Charles J, Castellino FJ, Ploplis VA. Past and Present Behçet's Disease Animal Models. Current Drug Targets. PMID 32682369 DOI: 10.2174/1389450121666200719010425  0.53
2020 Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, et al. Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacology & Translational Science. 3: 418-424. PMID 32566907 DOI: 10.1021/acsptsci.0c00001  0.698
2020 Chen P, Liu R, Huang M, Zhu J, Wei D, Castellino FJ, Dang G, Xie F, Li G, Cui Z, Liu S, Zhang Y. A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans. The Journal of Biological Chemistry. PMID 32518157 DOI: 10.1074/Jbc.Ra119.011977  0.322
2020 Qiu C, Yuan Y, Lee SW, Ploplis VA, Castellino FJ. A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen. The Biochemical Journal. PMID 32270857 DOI: 10.1042/Bcj20200197  0.572
2020 Carothers KE, Liang Z, Mayfield J, Donahue DL, Lee M, Boggess B, Ploplis VA, Castellino FJ, Lee SW. The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen USA300 through cleavage of the Staphylococcal SdrC protein. Journal of Bacteriology. PMID 32205460 DOI: 10.1128/Jb.00008-20  0.568
2020 Russo B, Ayinuola YA, Singh D, Carothers K, Fischetti VA, FloresMireles A, Lee SW, Ploplis VA, Liang Z, Castellino FJ. The M-protein of strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene. Journal of Bacteriology. PMID 32123038 DOI: 10.1128/Jb.00096-20  0.573
2020 Andrews WT, Donahue D, Holmes A, Balsara R, Castellino FJ, Hummon AB. In situ metabolite and lipid analysis of GluN2D and wild-type mice after ischemic stroke using MALDI MSI. Analytical and Bioanalytical Chemistry. PMID 32107573 DOI: 10.1007/S00216-020-02477-Z  0.641
2019 Liang Z, Carothers K, Holmes A, Donahue D, Lee SW, Castellino FJ, Ploplis VA. Stable genetic integration of a red fluorescent protein in a virulent Group A strain. Access Microbiology. 1: e000062. PMID 32974562 DOI: 10.1099/acmi.0.000062  0.491
2019 Ploplis VA, Castellino FJ. Host Pathways of Hemostasis that Regulate Group A Streptococcus Pyogenes Pathogenicity. Current Drug Targets. PMID 31556853 DOI: 10.2174/1389450120666190926152914  0.555
2019 Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ. Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis. Current Drug Targets. PMID 31309890 DOI: 10.2174/1389450120666190715102510  0.319
2019 Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ. Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. Journal of Structural Biology. PMID 31301349 DOI: 10.2210/Pdb6Oq9/Pdb  0.584
2019 Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP. Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. Journal of Molecular Biology. PMID 31295457 DOI: 10.1016/J.Jmb.2019.07.003  0.306
2019 Walsh M, Moore EE, Moore H, Thomas S, Lune SV, Zimmer D, Dynako J, Hake D, Crowell Z, McCauley R, Larson EE, Miller M, Pohlman T, Achneck HE, Martin P, ... ... Castellino FJ, et al. Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review. Seminars in Thrombosis and Hemostasis. PMID 31108555 DOI: 10.1055/S-0039-1688497  0.542
2019 Ly D, Donahue D, Walker MJ, Ploplis VA, McArthur JD, Ranson M, Castellino FJ, Sanderson-Smith ML. Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection. PMID 31009808 DOI: 10.1016/J.Micinf.2019.04.004  0.573
2019 Qiu C, Yuan Y, Liang Z, Lee SW, Ploplis VA, Castellino FJ. Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. Journal of Structural Biology. PMID 30880082 DOI: 10.1016/J.Jsb.2019.03.003  0.59
2019 Miyajima C, Iwaki T, Ploplis VA, Umemura K, Castellino FJ. Foam cell formation is regulated by plasmin in a murine model of type IIa hypercholesterolemia Proceedings For Annual Meeting of the Japanese Pharmacological Society. 92: 1-O-05. DOI: 10.1254/jpssuppl.92.0_1-o-05  0.484
2019 Liang Z, Carothers K, Holmes A, Donahue D, Lee SW, Castellino FJ, Ploplis VA. Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain Access Microbiology. 1. DOI: 10.1099/acmi.0.000062  0.464
2018 Qiu C, Yuan Y, Zajicek J, Liang Z, Balsara RD, Brito-Robionson T, Lee SW, Ploplis VA, Castellino FJ. Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization. Journal of Structural Biology. PMID 30071314 DOI: 10.1016/J.Jsb.2018.07.017  0.739
2018 Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW. Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Skin Infection. Frontiers in Cellular and Infection Microbiology. 8: 211. PMID 30018884 DOI: 10.3389/Fcimb.2018.00211  0.555
2018 Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ. Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia. Biomed Research International. 2018: 1878964. PMID 29977908 DOI: 10.1155/2018/1878964  0.559
2018 Liang Z, Stephens M, Ploplis VA, Lee SW, Castellino FJ. Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes. Genome Announcements. 6. PMID 29954901 DOI: 10.1128/Genomea.00592-18  0.515
2018 Urano T, Castellino FJ, Suzuki Y. Regulation of Plasminogen Activation on Cell Surfaces and Fibrin. Journal of Thrombosis and Haemostasis : Jth. PMID 29779246 DOI: 10.1111/Jth.14157  0.33
2018 Miles LA, Baik N, Bai H, Makarenkova HP, Kiosses WB, Krajewski S, Castellino FJ, Valenzuela A, Varki NM, Mueller BM, Parmer RJ. The Plasminogen ReceptorPlg-Ris Essential for Mammary Lobuloalveolar Development and Lactation. Journal of Thrombosis and Haemostasis : Jth. PMID 29495105 DOI: 10.1111/Jth.13988  0.329
2018 Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW. Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. The Journal of Antibiotics. PMID 29463889 DOI: 10.1038/S41429-018-0032-4  0.728
2017 Holmes A, Zhou N, Donahue DL, Balsara R, Castellino FJ. A deficiency of the GluN2C subunit of the N-Methyl-d-Aspartate receptor is neuroprotective in a mouse model of ischemic stroke. Biochemical and Biophysical Research Communications. PMID 29101031 DOI: 10.1016/J.Bbrc.2017.10.171  0.642
2017 Yuan Y, Zajicek J, Qiu C, Chandrahas V, Lee SW, Ploplis VA, Castellino FJ. Conformationally Organized Lysine Isosteres in Streptococcus Pyogenes M Protein Mediate Direct High-Affinity Binding to Human Plasminogen. The Journal of Biological Chemistry. PMID 28724633 DOI: 10.1074/Jbc.M117.794198  0.595
2017 Bao YJ, Li Y, Liang Z, Agrahari G, Lee SW, Ploplis VA, Castellino FJ. Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers. Pathogens and Disease. PMID 28520869 DOI: 10.1093/Femspd/Ftx056  0.54
2017 Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T. Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation. Thrombosis and Haemostasis. PMID 28492700 DOI: 10.1160/Th16-12-0920  0.331
2017 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Scientific Reports. 7: 365. PMID 28336948 DOI: 10.1038/S41598-017-00418-Y  0.566
2017 Glinton K, Beck J, Liang Z, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Variable Region in Streptococcal M-Proteins Provides Stable Binding with Host Fibrinogen for Plasminogen-Mediated Bacterial Invasion. The Journal of Biological Chemistry. PMID 28280245 DOI: 10.1074/Jbc.M116.768937  0.574
2017 Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinsek A, Lantry J, Sheppard F, ... Castellino F, et al. Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between". Seminars in Thrombosis and Hemostasis. PMID 28219085 DOI: 10.1055/S-0036-1597900  0.529
2016 Yuan Y, Balsara RD, Zajicek J, Kunda S, Castellino FJ. Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry. PMID 27981829 DOI: 10.1021/Acs.Biochem.6B00962  0.638
2016 Stroo I, Yang J, de Boer JD, Roelofs JJ, van 't Veer C, Castellino FJ, Zeerleder S, van der Poll T. Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00320.2016. PMID 27913422 DOI: 10.1152/Ajplung.00320.2016  0.32
2016 Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ. Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps. Scientific Reports. 6: 36644. PMID 27821851 DOI: 10.1038/Srep36644  0.536
2016 Higashi DL, Biais N, Donahue DL, Mayfield JA, Tessier CR, Rodriguez K, Ashfeld BL, Luchetti J, Ploplis VA, Castellino FJ, Lee SW. Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis. Nature Microbiology. 1: 15004. PMID 27571972 DOI: 10.1038/Nmicrobiol.2015.4  0.568
2016 Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ. Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potentials for evolutionary persistence. Microbiology (Reading, England). PMID 27329479 DOI: 10.1099/Mic.0.000326  0.536
2016 Gupta KK, Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through toll-like receptor-4. Biochemical and Biophysical Research Communications. PMID 27317488 DOI: 10.1016/J.Bbrc.2016.06.065  0.623
2016 Mamczak CN, Maloney M, Fritz B, Boyer B, Thomas S, Evans E, Ploplis VA, Castellino FJ, McCollester J, Walsh M. Thromboelastography in Orthopaedic Trauma Pelvic Fracture Resuscitation: A Descriptive Pilot Study. Journal of Orthopaedic Trauma. PMID 27206253 DOI: 10.1097/Bot.0000000000000537  0.499
2016 Yasui H, Donahue DL, Walsh M, Castellino FJ, Ploplis VA. Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00429.2015. PMID 27190065 DOI: 10.1152/Ajplung.00429.2015  0.52
2016 Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ. Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. Journal of Bacteriology. PMID 27044623 DOI: 10.1128/Jb.01019-15  0.563
2016 Walsh M, Fritz S, Hake D, Son M, Greve S, Jbara M, Chitta S, Fritz B, Miller A, Bader MK, McCollester J, Binz S, Liew-Spilge A, Thomas S, Crepinsek A, ... ... Castellino FJ, et al. Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy. Current Drug Targets. PMID 26960340 DOI: 10.2174/1389450117666160310153211  0.527
2016 Agrahari G, Liang Z, Glinton K, Lee SW, Ploplis VA, Castellino FJ. Streptococcus pyogenes employs strain-dependent mechanisms of C3b inactivation to inhibit phagocytosis and killing of bacteria. The Journal of Biological Chemistry. PMID 26945067 DOI: 10.1074/Jbc.M115.704221  0.584
2016 Cheriyan J, Balsara RD, Hansen KB, Castellino FJ. Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors. Neuroscience Letters. 617: 240-246. PMID 26917100 DOI: 10.1016/J.Neulet.2016.02.032  0.622
2015 Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH. A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood. PMID 26647393 DOI: 10.1182/Blood-2015-05-644260  0.328
2015 Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ. CovRS Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights on Virulence Determinants. Journal of Bacteriology. PMID 26216843 DOI: 10.1128/Jb.00511-15  0.541
2015 Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ. Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein. The Journal of Biological Chemistry. 290: 18833-42. PMID 26070561 DOI: 10.1074/Jbc.M115.655365  0.575
2015 Kunda S, Yuan Y, Balsara RD, Zajicek J, Castellino FJ. Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. The Journal of Biological Chemistry. 290: 18156-72. PMID 26048991 DOI: 10.1074/Jbc.M115.650341  0.656
2015 Balsara R, Dang A, Donahue DL, Snow T, Castellino FJ. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke. Plos One. 10: e0122840. PMID 25822337 DOI: 10.1371/Journal.Pone.0122840  0.617
2015 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. Plos One. 10: e0120728. PMID 25799354 DOI: 10.1371/Journal.Pone.0120728  0.58
2015 Cheriyan J, Mezes C, Zhou N, Balsara RD, Castellino FJ. Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine. Biochemistry. 54: 787-94. PMID 25544544 DOI: 10.1021/Bi501437S  0.631
2015 O’Rear J, Liew-Spilger A, Hall M, Duprat G, Graham E, Balint B, Aversa J, McDowell S, Ploplis V, Castellino F, Walsh M. The utility of modified thromboelastography with platelet mapping and functional fibrinogen to predict bleeding during catheter-directed thrombolysis: a pilot study Journal of Vascular and Interventional Radiology. 26: S10-S11. DOI: 10.1016/J.Jvir.2014.12.036  0.504
2014 Balsara RD, Chapman SE, Sander IM, Donahue DL, Liepert L, Castellino FJ, Leevy WM. Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG. Journal of Visualized Experiments : Jove. PMID 25590998 DOI: 10.3791/51495  0.592
2014 Bao Y, Liang Z, Booyjzsen C, Mayfield JA, Li Y, Lee SW, Ploplis VA, Song H, Castellino FJ. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. Journal of Bacteriology. 196: 4089-102. PMID 25225265 DOI: 10.1128/Jb.02131-14  0.545
2014 Huang L, Balsara RD, Castellino FJ. Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells. Journal of Neuroscience Research. 92: 1767-74. PMID 25043917 DOI: 10.1002/Jnr.23447  0.64
2014 Mayfield JA, Liang Z, Agrahari G, Lee SW, Donahue DL, Ploplis VA, Castellino FJ. Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence. Plos One. 9: e100698. PMID 24968349 DOI: 10.1371/Journal.Pone.0100698  0.551
2014 Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ. Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain. The Journal of Biological Chemistry. 289: 21684-93. PMID 24962580 DOI: 10.1074/Jbc.M114.570218  0.61
2014 Castellino FJ, Chapman MP, Donahue DL, Thomas S, Moore EE, Wohlauer MV, Fritz B, Yount R, Ploplis V, Davis P, Evans E, Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. The Journal of Trauma and Acute Care Surgery. 76: 1169-76. PMID 24747445 DOI: 10.1097/Ta.0000000000000216  0.546
2014 Ploplis VA, Donahue DL, Sandoval-Cooper MJ, MorenoCaffaro M, Sheets P, Thomas SG, Walsh M, Castellino FJ. Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury. Journal of Neurotrauma. 31: 1672-5. PMID 24605991 DOI: 10.1089/Neu.2013.3302  0.533
2014 Zhang Y, Mayfield JA, Ploplis VA, Castellino FJ. The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. Biochemical and Biophysical Research Communications. 444: 595-8. PMID 24486550 DOI: 10.1016/J.Bbrc.2014.01.109  0.582
2014 Balsara RD, Ferreira AN, Donahue DL, Castellino FJ, Sheets PL. Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons. Neuropharmacology. 79: 542-9. PMID 24440368 DOI: 10.1016/J.Neuropharm.2014.01.005  0.634
2014 Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. Journal of Thrombosis and Haemostasis : Jth. 12: 71-81. PMID 24175924 DOI: 10.1111/Jth.12442  0.325
2014 Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. Journal of Neurotrauma. 31: 404-10. PMID 24040968 DOI: 10.1089/neu.2013.3089  0.482
2013 Kunda S, Cheriyan J, Hur M, Balsara RD, Castellino FJ. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. Plos One. 8: e81405. PMID 24260577 DOI: 10.1371/Journal.Pone.0081405  0.658
2013 Agrahari G, Liang Z, Mayfield JA, Balsara RD, Ploplis VA, Castellino FJ. Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. The Journal of Biological Chemistry. 288: 27494-504. PMID 23928307 DOI: 10.1074/Jbc.M113.494864  0.736
2013 Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. Plos Pathogens. 9: e1003469. PMID 23853591 DOI: 10.1371/Journal.Ppat.1003469  0.579
2013 Zhang Y, Liang Z, Glinton K, Ploplis VA, Castellino FJ. Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. Febs Letters. 587: 1304-9. PMID 23474243 DOI: 10.1016/J.Febslet.2013.02.033  0.555
2013 Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ. A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. The Journal of Biological Chemistry. 288: 6561-73. PMID 23316057 DOI: 10.1074/Jbc.M112.442657  0.72
2013 Davis PK, Musunuru H, Walsh M, Cassady R, Yount R, Losiniecki A, Moore EE, Wohlauer MV, Howard J, Ploplis VA, Castellino FJ, Thomas SG. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocritical Care. 18: 201-8. PMID 22847397 DOI: 10.1007/S12028-012-9745-6  0.531
2012 Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. Abnormal whole blood thrombi in humans with inherited platelet receptor defects. Plos One. 7: e52878. PMID 23300803 DOI: 10.1371/Journal.Pone.0052878  0.702
2012 Bhattacharya S, Ploplis VA, Castellino FJ. Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. Journal of Biomedicine & Biotechnology. 2012: 482096. PMID 23118509 DOI: 10.1155/2012/482096  0.546
2012 Zhang Y, Liang Z, Hsueh HT, Ploplis VA, Castellino FJ. Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. The Journal of Biological Chemistry. 287: 42093-103. PMID 23086939 DOI: 10.1074/Jbc.M112.417808  0.583
2012 Narasaki R, Xu Z, Liang Z, Fung LC, Donahue D, Castellino FJ, Ploplis VA. The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. Journal of Thrombosis and Haemostasis : Jth. 10: 2618-21. PMID 23082983 DOI: 10.1111/Jth.12032  0.642
2012 Davis PK, Musunuru H, Walsh M, Mitra R, Ploplis V, Castellino FJ. The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. Thrombosis and Haemostasis. 108: 586-8. PMID 22782135 DOI: 10.1160/Th12-04-0222  0.52
2012 Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. Journal of the American College of Surgeons. 214: 739-46. PMID 22520693 DOI: 10.1016/J.Jamcollsurg.2012.01.050  0.529
2012 Balsara R, Li N, Weber-Adrian D, Huang L, Castellino FJ. Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology. 62: 2227-38. PMID 22306487 DOI: 10.1016/J.Neuropharm.2012.01.018  0.634
2012 Wohlauer MV, Thomas SG, Moore EE, Walsh M, Musunuru H, Davis PK, Evans E, Howard JC, Ploplis VA, Castellino FJ. Platelet dysfunction as an early marker for traumatic brain induced coagulopathy in the absence of platelet inhibitors Journal of the American College of Surgeons. 215: S60. DOI: 10.1016/J.Jamcollsurg.2012.06.169  0.517
2011 Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ. Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. The Journal of Extra-Corporeal Technology. 43: 162-7. PMID 22164456  0.462
2011 Vetrano S, Ploplis VA, Sala E, Sandoval-Cooper M, Donahue DL, Correale C, Arena V, Spinelli A, Repici A, Malesci A, Castellino FJ, Danese S. Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 108: 19830-5. PMID 22109555 DOI: 10.1073/Pnas.1107140108  0.573
2011 Guillen-Ahlers H, Tan J, Castellino FJ, Ploplis VA. Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29. Plos One. 6: e25725. PMID 21991341 DOI: 10.1371/Journal.Pone.0025725  0.537
2011 Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA. Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood. 118: 1653-62. PMID 21680799 DOI: 10.1182/Blood-2010-11-316943  0.362
2011 Balsara RD, Merryman R, Virjee F, Northway C, Castellino FJ, Ploplis VA. A deficiency of uPAR alters endothelial angiogenic function and cell morphology. Vascular Cell. 3: 10. PMID 21535874 DOI: 10.1186/2045-824X-3-10  0.725
2011 Dai Q, Dong M, Liu Z, Prorok M, Castellino FJ. Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. Journal of Inorganic Biochemistry. 105: 52-7. PMID 21134602 DOI: 10.1016/J.Jinorgbio.2010.10.002  0.321
2011 Cnudde SE, Prorok M, Jia X, Castellino FJ, Geiger JH. The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 257-66. PMID 21063741 DOI: 10.1007/S00775-010-0722-2  0.31
2011 Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M. An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood. 117: 283-9. PMID 20858853 DOI: 10.1182/Blood-2010-07-299057  0.575
2010 Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. The Journal of Clinical Investigation. 120: 3167-78. PMID 20714108 DOI: 10.1172/Jci42629  0.307
2010 Sheng Z, Prorok M, Castellino FJ. Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors. Neuroscience. 170: 703-10. PMID 20688135 DOI: 10.1016/J.Neuroscience.2010.07.056  0.325
2010 Wang M, Prorok M, Castellino FJ. NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain. Biophysical Journal. 99: 302-12. PMID 20655859 DOI: 10.1016/J.Bpj.2010.04.019  0.324
2010 Iwaki T, Malinverno C, Smith D, Xu Z, Liang Z, Ploplis VA, Castellino FJ. The generation and characterization of mice expressing a plasmin-inactivating active site mutation. Journal of Thrombosis and Haemostasis : Jth. 8: 2341-4. PMID 20653841 DOI: 10.1111/J.1538-7836.2010.03995.X  0.653
2010 Huang L, Balsara RD, Sheng Z, Castellino FJ. Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation. Molecular and Cellular Neurosciences. 45: 163-72. PMID 20600930 DOI: 10.1016/J.Mcn.2010.06.007  0.629
2010 Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. The Journal of Clinical Investigation. 120: 1971-80. PMID 20458145 DOI: 10.1172/Jci40380  0.352
2010 Xu Z, Xu H, Ploplis VA, Castellino FJ. Factor VII deficiency impairs cutaneous wound healing in mice. Molecular Medicine (Cambridge, Mass.). 16: 167-76. PMID 20454518 DOI: 10.2119/Molmed.2009.00171  0.681
2010 Cnudde SE, Prorok M, Castellino FJ, Geiger JH. Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 667-75. PMID 20195692 DOI: 10.1007/S00775-010-0633-2  0.319
2010 Figuera-Losada M, Ranson M, Sanderson-Smith ML, Walker MJ, Castellino FJ, Prorok M. Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). Biochimica Et Biophysica Acta. 1804: 1342-9. PMID 20152941 DOI: 10.1016/J.Bbapap.2010.01.019  0.806
2010 Guillen-Ahlers H, Suckow MA, Castellino FJ, Ploplis VA. Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. Plos One. 5: e9070. PMID 20140201 DOI: 10.1371/Journal.Pone.0009070  0.556
2010 Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood. 115: 2038-47. PMID 20009036 DOI: 10.1182/Blood-2009-09-244962  0.601
2010 Wang M, Zajicek J, Geiger JH, Prorok M, Castellino FJ. Solution structure of the complex of VEK-30 and plasminogen kringle 2. Journal of Structural Biology. 169: 349-59. PMID 19800007 DOI: 10.1016/J.Jsb.2009.09.011  0.324
2009 Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of Clinical Investigation. 119: 3437-49. PMID 19841542 DOI: 10.1172/Jci38476  0.32
2009 Battistel MD, Grishaev A, An SS, Castellino FJ, Llinás M. Solution structure and functional characterization of human plasminogen kringle 5. Biochemistry. 48: 10208-19. PMID 19821587 DOI: 10.1021/Bi901433N  0.317
2009 Gutiérrez-Fernández A, Gingles NA, Bai H, Castellino FJ, Parmer RJ, Miles LA. Plasminogen enhances neuritogenesis on laminin-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12393-400. PMID 19812315 DOI: 10.1523/Jneurosci.3553-09.2009  0.365
2009 Waldemarsson J, Stålhammar-Carlemalm M, Sandin C, Castellino FJ, Lindahl G. Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence. Plos One. 4: e7279. PMID 19794915 DOI: 10.1371/Journal.Pone.0007279  0.327
2009 Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. Journal of Thrombosis and Haemostasis : Jth. 7: 140-5. PMID 19630787 DOI: 10.1111/J.1538-7836.2009.03410.X  0.58
2009 Dai Q, Xiao C, Dong M, Liu Z, Sheng Z, Castellino FJ, Prorok M. Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues. Peptides. 30: 866-72. PMID 19428763 DOI: 10.1016/J.Peptides.2009.01.010  0.311
2009 Sheng Z, Liang Z, Geiger JH, Prorok M, Castellino FJ. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology. 57: 127-36. PMID 19427876 DOI: 10.1016/J.Neuropharm.2009.04.014  0.318
2009 Shinagawa K, Ploplis VA, Castellino FJ. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 296: L763-70. PMID 19286924 DOI: 10.1152/Ajplung.90638.2008  0.572
2009 Tang H, Fu Y, Lei Q, Han Q, Ploplis VA, Castellino FJ, Li L, Luo Y. Fibrinogen facilitates the anti-tumor effect of nonnative endostatin. Biochemical and Biophysical Research Communications. 380: 249-53. PMID 19167351 DOI: 10.1016/J.Bbrc.2009.01.045  0.545
2009 Tang H, Fu Y, Cui Y, He Y, Zeng X, Ploplis VA, Castellino FJ, Luo Y. Fibrinogen has chaperone-like activity. Biochemical and Biophysical Research Communications. 378: 662-7. PMID 19059206 DOI: 10.1016/J.Bbrc.2008.11.112  0.581
2009 Xu H, Noria F, Sandoval-Cooper MJ, Menchen H, Donahue DL, Ploplis VA, Castellino FJ. Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice. The Journal of Pathology. 217: 362-71. PMID 18973189 DOI: 10.1002/Path.2454  0.644
2009 Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 25-33. PMID 18841163 DOI: 10.1038/Jcbfm.2008.117  0.315
2009 Vulcano M, Vetrano S, Roncalli M, Spaggiari P, Gerlitz B, Grinnell B, Ploplis VA, Castellino FJ, Danese S. W1609 The Anticoagulant Protein C System Is Expressed and Functionally Active in Mucosal Dendritic and Epithelial Cells and Is Down-Regulated in IBD Patients Gastroenterology. 136: A-701-A-702. DOI: 10.1016/S0016-5085(09)63234-0  0.552
2009 Vetrano S, Ploplis VA, Sandoval-Cooper MJ, Donahue D, Arena V, Castellino FJ, Danese S. S1637 Unexpected Role of Coagulative Protein in Controlling Epithelial Barrier Integrity and Intestinal Inflammation Gastroenterology. 136: A-239-A-240. DOI: 10.1016/S0016-5085(09)61083-0  0.532
2008 Xiao C, Huang Y, Dong M, Hu J, Hou S, Castellino FJ, Prorok M, Dai Q. NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins. Neuropeptides. 42: 601-9. PMID 18992939 DOI: 10.1016/J.Npep.2008.09.003  0.301
2008 Iwaki T, Cruz-Topete D, Castellino FJ. A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice. Journal of Thrombosis and Haemostasis : Jth. 6: 1993-5. PMID 18761719 DOI: 10.1111/J.1538-7836.2008.03142.X  0.703
2008 Lay AJ, Northway CM, Donahue DL, Castellino FJ. Low levels of tissue factor rescue protein C-associated pregnancy failure in mice. Journal of Thrombosis and Haemostasis : Jth. 6: 1815-7. PMID 18647222 DOI: 10.1111/J.1538-7836.2008.03085.X  0.313
2008 Sheng Z, Prorok M, Brown BE, Castellino FJ. N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology. 55: 204-14. PMID 18602124 DOI: 10.1016/J.Neuropharm.2008.05.016  0.373
2008 Guillen-Ahlers H, Buechler SA, Suckow MA, Castellino FJ, Ploplis VA. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis. 29: 1421-7. PMID 18499699 DOI: 10.1093/Carcin/Bgn123  0.559
2008 Castellino FJ, Ploplis VA, Zhang L. gamma-Glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 446: 85-94. PMID 18373251 DOI: 10.1007/978-1-60327-084-7_6  0.582
2008 Iwaki T, Ploplis VA, Castellino FJ. The hemostasis system in murine atherosclerosis. Current Drug Targets. 9: 229-38. PMID 18336242 DOI: 10.2174/138945008783755593  0.56
2008 Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ. The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. The Journal of Biological Chemistry. 283: 1580-7. PMID 18039665 DOI: 10.1074/Jbc.M705063200  0.804
2008 Castellino FJ, Ploplis VA, Zhang L. γ-glutamate and β-hydroxyaspartate in proteins Methods in Molecular Biology. 446: 85-94. DOI: 10.1007/978-1-60327-84-7_6  0.456
2007 Ploplis VA, Tipton H, Menchen H, Castellino FJ. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. The Journal of Pathology. 213: 266-74. PMID 17893885 DOI: 10.1002/Path.2236  0.586
2007 Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. The Journal of Experimental Medicine. 204: 2439-48. PMID 17893198 DOI: 10.1084/Jem.20070404  0.341
2007 Dai Q, Sheng Z, Geiger JH, Castellino FJ, Prorok M. Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives. The Journal of Biological Chemistry. 282: 12641-9. PMID 17347154 DOI: 10.1074/Jbc.M609087200  0.321
2007 Cnudde SE, Prorok M, Dai Q, Castellino FJ, Geiger JH. The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. Journal of the American Chemical Society. 129: 1586-93. PMID 17243678 DOI: 10.1021/Ja065722Q  0.312
2007 Shinagawa K, Martin JA, Ploplis VA, Castellino FJ. Coagulation factor Xa modulates airway remodeling in a murine model of asthma. American Journal of Respiratory and Critical Care Medicine. 175: 136-43. PMID 17082493 DOI: 10.1164/Rccm.200608-1097Oc  0.558
2007 Lay AJ, Donahue D, Tsai MJ, Castellino FJ. Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood. 109: 1984-91. PMID 17047151 DOI: 10.1182/Blood-2006-07-037945  0.316
2007 Lay AJ, Donahue D, Tsai M, Castellino FJ. The Protective Role of Protein C in Endotoxin-Induced Shock. Blood. 110: 1748-1748. DOI: 10.1182/Blood.V110.11.1748.1748  0.325
2007 Xu H, Sandoval-Cooper M, Donahue DL, Ploplis VA, Castellino FJ. A FVII Deficiency Induces Cardiac Fibrosis in Mice Resulting in Systolic and Diastolic Dysfunction. Blood. 110: 1747-1747. DOI: 10.1182/Blood.V110.11.1747.1747  0.65
2006 Castellino FJ, Ganopolsky JG, Noria F, Sandoval-Cooper MJ, Ploplis VA. Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene. Thrombosis and Haemostasis. 96: 794-801. PMID 17139375 DOI: 10.1160/Th06-08-0430  0.781
2006 Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. The Journal of Pathology. 210: 488-96. PMID 17054310 DOI: 10.1002/Path.2073  0.659
2006 Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ. Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice. The Journal of Pathology. 210: 325-33. PMID 16981239 DOI: 10.1002/Path.2060  0.764
2006 Cnudde SE, Prorok M, Castellino FJ, Geiger JH. X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM. Biochemistry. 45: 11052-60. PMID 16964966 DOI: 10.1021/Bi060914J  0.337
2006 Green KA, Nielsen BS, Castellino FJ, Rømer J, Lund LR. Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Developmental Biology. 299: 164-75. PMID 16949567 DOI: 10.1016/J.Ydbio.2006.07.021  0.331
2006 Wei J, Dong M, Xiao C, Jiang F, Castellino FJ, Prorok M, Dai Q. Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. Neuroscience Letters. 405: 137-41. PMID 16859831 DOI: 10.1016/J.Neulet.2006.06.040  0.321
2006 Balsara RD, Castellino FJ, Ploplis VA. A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. The Journal of Biological Chemistry. 281: 22527-36. PMID 16785241 DOI: 10.1074/Jbc.M512819200  0.727
2006 Iwaki T, Castellino FJ. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thrombosis and Haemostasis. 95: 1003-10. PMID 16732380 DOI: 10.1160/Th06-03-0128  0.305
2006 Iwaki T, Sandoval-Cooper MJ, Brechmann M, Ploplis VA, Castellino FJ. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood. 107: 3883-91. PMID 16434491 DOI: 10.1182/Blood-2005-09-3780  0.576
2006 Busquets L, Guillen H, DeFord ME, Suckow MA, Navari RM, Castellino FJ, Prorok M. Cathepsin E is a specific marker of dysplasia in APC mouse intestine. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 27: 36-42. PMID 16340248 DOI: 10.1159/000090154  0.313
2006 Joyce DE, Xu H, Mathur S, Castellino FJ. Performance of Murine Soluble Thrombomodulin (rmsTM) in a Murine Model of Endotoxin-Induced Sepsis. Blood. 108: 3933-3933. DOI: 10.1182/Blood.V108.11.3933.3933  0.51
2006 Kerschen EJ, Cooley BC, Castellino FJ, Coughlin SR, Fernandez JA, Griffin JH, Weiler H. Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis. Blood. 108: 1-1. DOI: 10.1182/Blood.V108.11.1.1  0.332
2006 Bai H, Dehmelt L, Halpain S, Ploplis V, Castellino F, Parmer R, Miles L. ID: 365 Role of the Plasminogen Activation System in Hippocampal Neuritogenesis Journal of Thrombosis and Haemostasis. 4: 146-146. DOI: 10.1111/J.1538-7836.2006.00365.X  0.543
2006 Iwaki T, Sandoval-Cooper M, Ploplis V, Castellino F. ID: 291 Fibrinogen deficiency and LDL driven atherosclerosis in mice Journal of Thrombosis and Haemostasis. 4: 104-104. DOI: 10.1111/J.1538-7836.2006.00291.X  0.553
2006 Cruz-Topete D, Iwaki T, Ploplis V, Castellino F. ID: 231 The role of fibrinogen in a murine model of lethal endotoxemia Journal of Thrombosis and Haemostasis. 4: 103-103. DOI: 10.1111/J.1538-7836.2006.00231.X  0.741
2005 Rosen ED, Xu H, Liang Z, Martin JA, Suckow M, Castellino FJ. Generation of genetically-altered mice producing very low levels of coagulation factorVII. Thrombosis and Haemostasis. 94: 493-7. PMID 16268461 DOI: 10.1160/Th05-05-0337  0.505
2005 Dai Q, Prorok M, Castellino FJ. Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties. Biochemistry. 44: 12508-14. PMID 16156662 DOI: 10.1021/BI050974+  0.377
2005 Lay AJ, Liang Z, Rosen ED, Castellino FJ. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. The Journal of Clinical Investigation. 115: 1552-61. PMID 15902301 DOI: 10.1172/Jci24030  0.323
2005 Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system. Thrombosis and Haemostasis. 93: 647-54. PMID 15841308 DOI: 10.1160/Th04-12-0842  0.59
2005 Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Gröger M, Wolff K, Zacharowski K. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nature Medicine. 11: 298-304. PMID 15723073 DOI: 10.1038/Nm1198  0.302
2005 Iwaki T, Cruz DT, Martin JA, Castellino FJ. A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood. 105: 2364-71. PMID 15528312 DOI: 10.1182/Blood-2004-06-2456  0.33
2005 Joyce DE, Donahue DL, Liaw PC, Castellino FJ. Recombinant Human Activated Protein C Suppresses Endotoxin Induced Hypotension in Mice Deficient of the Endothelial Protein C Receptor (EPCR). Blood. 106: 3696-3696. DOI: 10.1182/Blood.V106.11.3696.3696  0.34
2005 Kerschen EJ, Cooley BC, Castellino FJ, Griffin JH, Weiler H. Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action. Blood. 106: 26-26. DOI: 10.1182/Blood.V106.11.26.26  0.357
2004 Dai Q, Castellino FJ, Prorok M. A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. Biochemistry. 43: 13225-32. PMID 15476416 DOI: 10.1021/Bi048796S  0.308
2004 Ganopolsky JG, Castellino FJ. A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. The American Journal of Pathology. 165: 1433-46. PMID 15466407 DOI: 10.1016/S0002-9440(10)63401-3  0.755
2004 Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF. A central role for plasminogen in the inflammatory response to biomaterials. Journal of Thrombosis and Haemostasis : Jth. 2: 1798-805. PMID 15456492 DOI: 10.1111/J.1538-7836.2004.00916.X  0.569
2004 Dai Q, Prorok M, Castellino FJ. A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. Journal of Molecular Biology. 336: 731-44. PMID 15095984 DOI: 10.1016/J.Jmb.2003.12.027  0.35
2004 Sazonova IY, Robinson BR, Gladysheva IP, Castellino FJ, Reed GL. alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator. The Journal of Biological Chemistry. 279: 24994-5001. PMID 15069059 DOI: 10.1074/Jbc.M400253200  0.333
2004 Xu Z, Balsara RD, Gorlatova NV, Lawrence DA, Castellino FJ, Ploplis VA. Conservation of critical functional domains in murine plasminogen activator inhibitor-1. The Journal of Biological Chemistry. 279: 17914-20. PMID 14963029 DOI: 10.1074/Jbc.M314197200  0.761
2004 Ploplis VA, Balsara R, Sandoval-Cooper MJ, Yin ZJ, Batten J, Modi N, Gadoua D, Donahue D, Martin JA, Castellino FJ. Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. The Journal of Biological Chemistry. 279: 6143-51. PMID 14625301 DOI: 10.1074/Jbc.M307297200  0.726
2004 Xu H, Ploplis VA, Joyce DE, Castellino FJ. A Factor VII Deficiency Protects Against Lethal Endotoxemia in Mice. Blood. 104: 694-694. DOI: 10.1182/Blood.V104.11.694.694  0.665
2004 Martin JA, Joyce DE, Balsara R, Ploplis VA, Castellino FJ. Challenge with LPS or TNF-α Demonstrates Unique Differences in Primary Arterial Endothelial Cells Pretreated with Recombinant Human Activated Protein C. Blood. 104: 1935-1935. DOI: 10.1182/Blood.V104.11.1935.1935  0.715
2003 Dai Q, Zajicek J, Castellino FJ, Prorok M. Binding and orientation of conantokins in PL vesicles and aligned PL multilayers. Biochemistry. 42: 12511-21. PMID 14580197 DOI: 10.1021/Bi034918P  0.328
2003 Iwaki T, Figuera M, Ploplis VA, Castellino FJ. Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques. 35: 482-4, 486. PMID 14513552 DOI: 10.2144/03353Bm08  0.506
2003 Paoni NF, Feldman MW, Gutierrez LS, Ploplis VA, Castellino FJ. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiological Genomics. 15: 228-35. PMID 13130079 DOI: 10.1152/Physiolgenomics.00078.2003  0.546
2003 Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. The American Journal of Pathology. 163: 517-31. PMID 12875972 DOI: 10.1016/S0002-9440(10)63680-2  0.573
2003 Zhang L, Gong Y, Grella DK, Castellino FJ, Miles LA. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface. Journal of Thrombosis and Haemostasis : Jth. 1: 1264-70. PMID 12871329 DOI: 10.1046/J.1538-7836.2003.00155.X  0.304
2003 Klein RC, Prorok M, Castellino FJ. Direct binding properties of conantokins to native N-methyl-d-aspartate receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 307-17. PMID 12753378 DOI: 10.1034/J.1399-3011.2003.00059.X  0.586
2003 Mundada LV, Prorok M, DeFord ME, Figuera M, Castellino FJ, Fay WP. Structure-function analysis of the streptokinase amino terminus (residues 1-59). The Journal of Biological Chemistry. 278: 24421-7. PMID 12704199 DOI: 10.1074/Jbc.M301825200  0.339
2003 Wu SC, Castellino FJ, Wong SL. A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy. The Journal of Biological Chemistry. 278: 18199-206. PMID 12646571 DOI: 10.1074/Jbc.M210919200  0.326
2003 Gutierrez LS, Suckow M, Lawler J, Ploplis VA, Castellino FJ. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 24: 199-207. PMID 12584168 DOI: 10.1093/Carcin/24.2.199  0.567
2003 Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine. 9: 338-42. PMID 12563316 DOI: 10.1038/Nm826  0.312
2002 Castellino FJ, Liang Z, Volkir SP, Haalboom E, Martin JA, Sandoval-Cooper MJ, Rosen ED. Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. Thrombosis and Haemostasis. 88: 462-72. PMID 12353077 DOI: 10.1055/S-0037-1613239  0.328
2002 Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH. The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. Journal of Molecular Biology. 318: 1009-17. PMID 12054798 DOI: 10.1016/S0022-2836(02)00211-5  0.316
2002 Castellino FJ, Ploplis VA, Zhang L. gamma-glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 194: 259-68. PMID 12029840 DOI: 10.1385/1-59259-181-7:259  0.461
2002 Iwaki T, Sandoval-Cooper MJ, Paiva M, Kobayashi T, Ploplis VA, Castellino FJ. Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. The American Journal of Pathology. 160: 1021-34. PMID 11891199 DOI: 10.1016/S0002-9440(10)64923-1  0.536
2002 Ploplis VA, Castellino FJ. Gene targeting of components of the fibrinolytic system. Thrombosis and Haemostasis. 87: 22-31. PMID 11848453 DOI: 10.1055/S-0037-1612938  0.55
2001 Loy JA, Lin X, Schenone M, Castellino FJ, Zhang XC, Tang J. Domain interactions between streptokinase and human plasminogen. Biochemistry. 40: 14686-95. PMID 11724583 DOI: 10.1021/Bi011309D  0.622
2001 Chan JC, Duszczyszyn DA, Castellino FJ, Ploplis VA. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. The American Journal of Pathology. 159: 1681-8. PMID 11696429 DOI: 10.1016/S0002-9440(10)63015-5  0.56
2001 Klein RC, Warder SE, Galdzicki Z, Castellino FJ, Prorok M. Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides. Neuropharmacology. 41: 801-10. PMID 11684144 DOI: 10.1016/S0028-3908(01)00119-8  0.777
2001 Klein RC, Castellino FJ. Activators and inhibitors of the ion channel of the NMDA receptor. Current Drug Targets. 2: 323-9. PMID 11554556 DOI: 10.2174/1389450013348290  0.556
2001 Prorok M, Castellino FJ. Structure-function relationships of the NMDA receptor antagonist conantokin peptides. Current Drug Targets. 2: 313-22. PMID 11554555 DOI: 10.2174/1389450013348542  0.322
2001 Wilberding JA, Ploplis VA, McLennan L, Liang Z, Cornelissen I, Feldman M, Deford ME, Rosen ED, Castellino FJ. Development of pulmonary fibrosis in fibrinogen-deficient mice. Annals of the New York Academy of Sciences. 936: 542-8. PMID 11460513 DOI: 10.1111/J.1749-6632.2001.Tb03542.X  0.576
2001 Ploplis VA, Castellino FJ. Attenuation of neointima formation following arterial injury in PAI-1 deficient mice. Annals of the New York Academy of Sciences. 936: 466-8. PMID 11460504 DOI: 10.1111/J.1749-6632.2001.Tb03533.X  0.544
2001 Castellino FJ. Gene targeting in hemostasis: protein C. Frontiers in Bioscience : a Journal and Virtual Library. 6: D807-19. PMID 11438441 DOI: 10.2741/Castelli  0.353
2001 Rios-Steiner JL, Schenone M, Mochalkin I, Tulinsky A, Castellino FJ. Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. Journal of Molecular Biology. 308: 705-19. PMID 11350170 DOI: 10.1006/Jmbi.2001.4646  0.641
2001 Klein RC, Prorok M, Galdzicki Z, Castellino FJ. The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 276: 26860-7. PMID 11335724 DOI: 10.1074/Jbc.M102428200  0.596
2001 Warder SE, Blandl T, Klein RC, Castellino FJ, Prorok M. Amino acid determinants for NMDA receptor inhibition by conantokin-T. Journal of Neurochemistry. 77: 812-22. PMID 11331410 DOI: 10.1046/J.1471-4159.2001.00281.X  0.787
2001 Gong Y, Kim SO, Felez J, Grella DK, Castellino FJ, Miles LA. Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. The Journal of Biological Chemistry. 276: 19078-83. PMID 11264290 DOI: 10.1074/Jbc.M101387200  0.31
2001 Klein RC, Siarey RJ, Caruso A, Rapoport SI, Castellino FJ, Galdzicki Z. Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons. Journal of Neurochemistry. 76: 1663-9. PMID 11259484 DOI: 10.1046/J.1471-4159.2001.00170.X  0.55
2001 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ. The characterization of mice with a targeted combined deficiency of protein c and factor XI. The American Journal of Pathology. 158: 469-79. PMID 11159184 DOI: 10.1016/S0002-9440(10)63989-2  0.786
2001 Ploplis VA, Cornelissen I, Sandoval-Cooper MJ, Weeks L, Noria FA, Castellino FJ. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. The American Journal of Pathology. 158: 107-17. PMID 11141484 DOI: 10.1016/S0002-9440(10)63949-1  0.565
2001 Blandl T, Zajicek J, Prorok M, Castellino FJ. Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R. The Journal of Biological Chemistry. 276: 7391-6. PMID 11096077 DOI: 10.1074/Jbc.M006648200  0.77
2000 Schenone MM, Warder SE, Martin JA, Prorok M, Castellino FJ. An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 438-45. PMID 11152303 DOI: 10.1034/J.1399-3011.2000.00810.X  0.794
2000 Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ. Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Research. 60: 5839-47. PMID 11059781  0.514
2000 Ploplis VA, Wilberding J, McLennan L, Liang Z, Cornelissen I, DeFord ME, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. The American Journal of Pathology. 157: 703-8. PMID 10980108 DOI: 10.1016/S0002-9440(10)64582-8  0.565
2000 Ploplis VA, Castellino FJ. Nonfibrinolytic functions of plasminogen. Methods (San Diego, Calif.). 21: 103-10. PMID 10816371 DOI: 10.1006/Meth.2000.0981  0.589
2000 Chan JC, Cornelissen I, Collen D, Ploplis VA, Castellino FJ. Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. The Journal of Clinical Investigation. 105: 897-903. PMID 10749569 DOI: 10.1172/Jci9095  0.566
2000 Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino FJ, Collen D, Rosen ED. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice Thrombosis and Haemostasis. 83: 185-190. PMID 10739370 DOI: 10.1055/S-0037-1613783  0.302
2000 Blandl T, Warder SE, Prorok M, Castellino FJ. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. Febs Letters. 470: 139-46. PMID 10734223 DOI: 10.1016/S0014-5793(00)01309-0  0.792
2000 Schenone MM, Warder SE, Martin JA, Prokok M, Castellino FJ. Binding of RAM-derived peptides to the recombinant kringle 2 domain of human plasminogen Fibrinolysis and Proteolysis. 14: 23.  0.776
2000 Ploplis VA, Cornelissen I, Paul C, Sandoval-Cooper M, Castellino FJ. Two novel vascular injury models demonstrate a role for urokinase in early vascular repair events Fibrinolysis and Proteolysis. 14: 20.  0.459
2000 Ploplis VA, Wilberding J, Cornelissen I, Defokdm E, Uang Z, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice Fibrinolysis and Proteolysis. 14: 11.  0.49
1999 Klein RC, Galdzicki Z, Castellino FJ. Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology. 38: 1819-29. PMID 10608277 DOI: 10.1016/S0028-3908(99)00065-9  0.573
1999 Klein RC, Castellino FJ. Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T. Neuroscience Letters. 273: 171-4. PMID 10515186 DOI: 10.1016/S0304-3940(99)00649-7  0.584
1999 Nilsen SL, Prorok M, Castellino FJ. Enhancement through mutagenesis of the binding of the isolated kringle 2 domain of human plasminogen to ω-amino acid ligands and to an internal sequence of a Streptococcal surface protein Journal of Biological Chemistry. 274: 22380-22386. PMID 10428809 DOI: 10.1074/Jbc.274.32.22380  0.309
1999 Chang Y, Nilsen SL, Castellino FJ. Functional and structural consequences of aromatic residue substitutions within the kringle-2 domain of tissue-type plasminogen activator Journal of Peptide Research. 53: 656-664. PMID 10408340 DOI: 10.1034/J.1399-3011.1999.00078.X  0.341
1999 Blandl T, Warder SE, Prorok M, Castellino FJ. Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 453-64. PMID 10406223 DOI: 10.1034/J.1399-3011.1999.00042.X  0.786
1999 Nilsen SL, Castellino FJ. Expression of human plasminogen in Drosophila Schneider S2 cells Protein Expression and Purification. 16: 136-143. PMID 10336871 DOI: 10.1006/Prep.1999.1045  0.305
1999 Miele RG, Prorok M, Costa VA, Castellino FJ. Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity. The Journal of Biological Chemistry. 274: 7769-76. PMID 10075668 DOI: 10.1074/Jbc.274.12.7769  0.785
1999 Chan JCY, Carmeliet P, Moons L, Rosen ED, Huang ZF, Broze GJ, Collen D, Castellino FJ. Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit Journal of Clinical Investigation. 103: 475-482. PMID 10021455 DOI: 10.1172/Jci5678  0.309
1998 Jalbert LR, Rosen ED, Moons L, Chan JCY, Carmeliet P, Collen D, Castellino FJ. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice Journal of Clinical Investigation. 102: 1481-1488. PMID 9788960 DOI: 10.1172/Jci3011  0.314
1998 Blandl T, Prorok M, Castellino FJ. NMDA-receptor antagonist requirements in conantokin-G. Febs Letters. 435: 257-62. PMID 9762921 DOI: 10.1016/S0014-5793(98)01077-1  0.773
1998 Wistedt AC, Kotarsky H, Marti D, Ringdahl U, Castellino FJ, Schaller J, Sjöbring U. Kringle 2 mediates high affinity binding of plasminogen to an internal sequence in streptococcal surface protein PAM Journal of Biological Chemistry. 273: 24420-24424. PMID 9733732 DOI: 10.1074/Jbc.273.38.24420  0.334
1998 Duman JG, Miele RG, Liang H, Grella DK, Sim KL, Castellino FJ, Bretthauer RK. O-Mannosylation of Pichia pastoris cellular and recombinant proteins. Biotechnology and Applied Biochemistry. 28: 39-45. PMID 9693087 DOI: 10.1111/J.1470-8744.1998.Tb00510.X  0.775
1998 Liang Z, Cooper A, DeFord ME, Carmeliet P, Collen D, Castellino FJ, Rosen ED. Cloning and characterization of a cDNA encoding murine coagulation factor X Thrombosis and Haemostasis. 80: 87-91. PMID 9684791 DOI: 10.1055/S-0037-1615144  0.302
1998 Prorok M, Castellino FJ. Thermodynamics of binding of calcium, magnesium, and zinc to the N- methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T Journal of Biological Chemistry. 273: 19573-19578. PMID 9677382 DOI: 10.1074/Jbc.273.31.19573  0.335
1998 Ji WR, Barrientos LG, Llinás M, Gray H, Villarreal X, Deford ME, Castellino FJ, Kramer RA, Trail PA. Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis Biochemical and Biophysical Research Communications. 247: 414-419. PMID 9642142 DOI: 10.1006/Bbrc.1998.8825  0.304
1998 Chen Z, Blandl T, Prorok M, Warder SE, Li L, Zhu Y, Pedersen LG, Ni F, Castellino FJ. Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis. The Journal of Biological Chemistry. 273: 16248-58. PMID 9632684 DOI: 10.1074/Jbc.273.26.16248  0.785
1998 Chang Y, Mochalkin I, McCance SG, Cheng B, Tulinsky A, Castellino FJ. Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. Biochemistry. 37: 3258-71. PMID 9521645 DOI: 10.1021/Bi972284E  0.328
1998 Warder SE, Prorok M, Chen Z, Li L, Zhu Y, Pedersen LG, Ni F, Castellino FJ. The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T. The Journal of Biological Chemistry. 273: 7512-22. PMID 9516452 DOI: 10.1074/Jbc.273.13.7512  0.702
1998 Cheng CH, Geng JP, Castellino FJ. The functions of the first epidermal growth factor homology region of human protein C as revealed by a charge-to-alanine scanning mutagenesis investigation. Biological Chemistry. 378: 1491-500. PMID 9461348 DOI: 10.1515/Bchm.1997.378.12.1491  0.313
1997 Blandl T, Zajicek J, Prorok M, Castellino FJ. Metal-ion-binding properties of synthetic conantokin-G. The Biochemical Journal. 328: 777-83. PMID 9396720 DOI: 10.1042/Bj3280777  0.748
1997 Gately S, Twardowski P, Stack MS, Cundiff DL, Grella D, Castellino FJ, Enghild J, Kwaan HC, Lee F, Kramer RA, Volpert O, Bouck N, Soff GA. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proceedings of the National Academy of Sciences of the United States of America. 94: 10868-72. PMID 9380726 DOI: 10.1073/Pnas.94.20.10868  0.317
1997 Miele RG, Castellino FJ, Bretthauer RK. Characterization of the acidic oligosaccharides assembled on the Pichia pastoris-expressed recombinant kringle 2 domain of human tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 26: 79-83. PMID 9357103 DOI: 10.1111/J.1470-8744.1997.Tb00450.X  0.781
1997 Castellino FJ, Geng JP. Expression of human anticoagulation protein C and gamma-carboxyglutamic acid mutants in mammalian cell cultures. Methods in Enzymology. 282: 369-84. PMID 9330302 DOI: 10.1016/S0076-6879(97)82121-0  0.307
1997 Warder SE, Chen Z, Zhu Y, Prorok M, Castellino FJ, Ni F. The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions. Febs Letters. 411: 19-26. PMID 9247135 DOI: 10.1016/S0014-5793(97)00573-5  0.725
1997 Wang H, Prorok M, Bretthauer RK, Castellino FJ. Serine-578 is a major phosphorylation locus in human plasma plasminogen. Biochemistry. 36: 8100-6. PMID 9201958 DOI: 10.1021/Bi970328D  0.311
1997 Chang Y, Zajicek J, Castellino FJ. Role of tryptophan-63 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability, folding, and ligand binding properties. Biochemistry. 36: 7652-63. PMID 9201906 DOI: 10.1021/Bi970197G  0.346
1997 Miele RG, Nilsen SL, Brito T, Bretthauer RK, Castellino FJ. Glycosylation properties of the Pichia pastoris-expressed recombinant kringle 2 domain of tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 25: 151-7. PMID 9127488 DOI: 10.1111/J.1470-8744.1997.Tb00427.X  0.786
1997 Thariath A, Castellino FJ. Highly conserved residue arginine-15 is required for the Ca2+-dependent properties of the gamma-carboxyglutamic acid domain of human anticoagulation protein C and activated protein C. The Biochemical Journal. 309-15. PMID 9078278 DOI: 10.1042/Bj3220309  0.34
1997 Nilsen SL, DeFord ME, Prorok M, Chibber BA, Bretthauer RK, Castellino FJ. High-level secretion in Pichia pastoris and biochemical characterization of the recombinant kringle 2 domain of tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 25: 63-74. PMID 9032937 DOI: 10.1111/J.1470-8744.1997.Tb00415.X  0.338
1997 Grella DK, Castellino FJ. Activation of Human Plasminogen by Staphylokinase. Direct Evidence That Preformed Plasmin Is Necessary for Activation to Occur Blood. 89: 1585-1589. DOI: 10.1182/Blood.V89.5.1585.1585_1585_1589  0.307
1997 Geng J, Castellino FJ. Properties of a Recombinant Chimeric Protein in which the gamma-Carboxyglutamic Acid and Helical Stack Domains of Human Anticoagulant Protein C Are Replaced by those of Human Coagulation Factor VII Thrombosis and Haemostasis. 77: 0926-0933. DOI: 10.1055/S-0038-1656079  0.362
1996 Prorok M, Warder SE, Blandl T, Castellino FJ. Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail "sleeper" peptides, conantokin-G and conantokin-T. Biochemistry. 35: 16528-34. PMID 8987986 DOI: 10.1021/Bi9621122  0.783
1996 Prorok M, Geng JP, Warder SE, Castellino FJ. The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor. International Journal of Peptide and Protein Research. 48: 281-5. PMID 8897096 DOI: 10.1111/J.1399-3011.1996.Tb00842.X  0.737
1996 Jalbert LR, Chan JCY, Christiansen WT, Castellino FJ. The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles Biochemistry. 35: 7093-7099. PMID 8679535 DOI: 10.1021/Bi960290P  0.34
1996 Mathews II, Vanderhoff-Hanaver P, Castellino FJ, Tulinsky A. Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Biochemistry. 35: 2567-76. PMID 8611560 DOI: 10.1021/Bi9521351  0.3
1996 Geng J, Cheng C, Castellino FJ. Functional Consequences of Mutations in Amino Acid Residues that Stabilize Calcium Binding to the First Epidermal Growth Factor Homology Domain of Human Protein C Thrombosis and Haemostasis. 76: 720-728. DOI: 10.1055/S-0038-1650650  0.332
1996 Geng J, Castellino FJ. The Propeptides of Human Protein C, Factor VII, and Factor IX Are Exchangeable with Regard to Directing Gamma-Carboxylation of these Proteins Thrombosis and Haemostasis. 76: 205-207. DOI: 10.1055/S-0038-1650555  0.321
1995 Menhart N, Castellino FJ. The importance of the hydrophobic components of the binding energies in the interaction of ω-amino acid ligands with isolated kringle polypeptide domains of human plasminogen International Journal of Peptide and Protein Research. 46: 464-470. PMID 8748706 DOI: 10.1111/J.1399-3011.1995.Tb01601.X  0.319
1995 Ren J, Bretthauer RK, Castellino FJ. Purification and properties of a Golgi-derived (alpha 1,2)-mannosidase-I from baculovirus-infected lepidopteran insect cells (IPLB-SF21AE) with preferential activity toward mannose6-N-acetylglucosamine2. Biochemistry. 34: 2489-95. PMID 7873528 DOI: 10.1021/Bi00008A012  0.317
1995 Colpitts TL, Prorok M, Castellino FJ. Binding of calcium to individual gamma-carboxyglutamic acid residues of human protein C. Biochemistry. 34: 2424-30. PMID 7873521 DOI: 10.1021/Bi00008A004  0.319
1995 Menhart N, Hoover GJ, McCance SG, Castellino FJ. Roles of individual kringle domains in the functioning of positive and negative effectors of human plasminogen activation Biochemistry. 34: 1482-1488. PMID 7849007 DOI: 10.1021/Bi00005A003  0.318
1995 Christiansen WT, Geng JP, Castellino FJ. Structure-function assessment of the role of the helical stack domain in the properties of human recombinant protein C and activated protein C. Biochemistry. 34: 8082-90. PMID 7794921 DOI: 10.1021/Bi00025A014  0.332
1995 Christiansen WT, Jalbert LR, Robertson RM, Jhingan A, Prorok M, Castellino FJ. Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid Vesicles. Biochemistry. 34: 10376-82. PMID 7654691 DOI: 10.1021/Bi00033A008  0.332
1995 McCance SG, Castellino FJ. Contributions of individual kringle domains toward maintenance of the chloride-induced tight conformation of human glutamic acid-1 plasminogen. Biochemistry. 34: 9581-6. PMID 7626628 DOI: 10.1021/Bi00029A035  0.313
1995 Geng JP, Christiansen WT, Plow EF, Castellino FJ. Transfer of specific endothelial cell-binding properties from the procoagulant protein human factor IX into the anticoagulant protein human protein C. Biochemistry. 34: 8449-57. PMID 7541242 DOI: 10.1021/Bi00026A028  0.355
1994 De Serrano VS, Castellino FJ. Role of the strictly conserved tryptophan-25 residue in the stabilization of the structure and in the ligand binding properties of the kringle 2 domain of tissue-type plasminogen activator. Biochemistry. 33: 1340-4. PMID 8312251 DOI: 10.1021/Bi00172A008  0.313
1994 Yu S, Zhang L, Jhingan A, Christiansen WT, Castellino FJ. Construction, expression, and properties of a recombinant chimeric human protein C with replacement of its growth factor-like domains by those of human coagulation factor IX. Biochemistry. 33: 823-31. PMID 8292611 DOI: 10.1021/Bi00169A025  0.323
1994 Christiansen WT, Castellino FJ. Properties of recombinant chimeric human protein C and activated protein C containing the gamma-carboxyglutamic acid and trailing helical stack domains of protein C replaced by those of human coagulation factor IX. Biochemistry. 33: 5901-11. PMID 8180219 DOI: 10.1021/Bi00185A030  0.31
1994 De Serrano VS, Castellino FJ. Involvement of tyrosine-76 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability and its omega-amino acid ligand binding site. Biochemistry. 33: 3509-14. PMID 8142348 DOI: 10.1021/Bi00178A007  0.327
1994 Colpitts TL, Castellino FJ. Calcium and phospholipid binding properties of synthetic gamma-carboxyglutamic acid-containing peptides with sequence counterparts in human protein C. Biochemistry. 33: 3501-8. PMID 8142347 DOI: 10.1021/Bi00178A006  0.349
1994 Jhingan A, Zhang L, Christiansen WT, Castellino FJ. The activities of recombinant gamma-carboxyglutamic-acid-deficient mutants of activated human protein C toward human coagulation factor Va and factor VIII in purified systems and in plasma. Biochemistry. 33: 1869-75. PMID 8110790 DOI: 10.1021/Bi00173A033  0.31
1994 Christiansen WT, Tulinsky A, Castellino FJ. Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein c. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium. Biochemistry. 33: 14993-5000. PMID 7999756 DOI: 10.1021/Bi00254A007  0.326
1993 Boutaud A, Castellino FJ. The construction and expression of chimeric urokinase-type plasminogen activator genes containing kringle domains of human plasminogen. Archives of Biochemistry and Biophysics. 303: 222-30. PMID 8512311 DOI: 10.1006/Abbi.1993.1276  0.33
1993 Mhashilkar AM, Viswanatha T, Chibber BAK, Castellino FJ. Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: Localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin Proceedings of the National Academy of Sciences of the United States of America. 90: 5374-5377. PMID 8506386 DOI: 10.1073/Pnas.90.11.5374  0.331
1993 Colpitts TL, Castellino FJ. Binding of calcium to synthetic peptides containing gamma-carboxyglutamic acid. International Journal of Peptide and Protein Research. 41: 567-75. PMID 8349415 DOI: 10.1111/J.1399-3011.1993.Tb00479.X  0.327
1993 Castellino FJ, Davidson DJ, Rosen E, McLinden J. Expression of human plasminogen cDNA in lepidopteran insect cells and analysis of asparagine-linked glycosylation patterns of recombinant plasminogens. Methods in Enzymology. 223: 168-85. PMID 8271951 DOI: 10.1016/0076-6879(93)23044-N  0.308
1993 Radek JT, Davidson DJ, Castellino FJ. Streptokinase-plasmin(ogen) activator assays. Methods in Enzymology. 223: 145-55. PMID 8271949 DOI: 10.1016/0076-6879(93)23042-L  0.303
1993 Hoover GJ, Menhart N, Martin A, Warder S, Castellino FJ. Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with omega-amino acids. Biochemistry. 32: 10936-43. PMID 8218159 DOI: 10.1021/Bi00092A002  0.72
1992 De Serrano VS, Castellino FJ. Role of tryptophan-74 of the recombinant kringle 2 domain of tissue-type plasminogen activator in its omega-amino acid binding properties. Biochemistry. 31: 3326-35. PMID 1554717 DOI: 10.1021/Bi00128A004  0.316
1992 DeSerrano VS, Menhart N, Castellino FJ. Expression, purification, and characterization of the recombinant kringle 1 domain from tissue-type plasminogen activator Archives of Biochemistry and Biophysics. 294: 282-290. PMID 1550352 DOI: 10.1016/0003-9861(92)90170-2  0.325
1992 De Serrano VS, Castellino FJ. The cationic locus on the recombinant kringle 2 domain of tissue-type plasminogen activator that stabilizes its interaction with omega-amino acids. Biochemistry. 31: 11698-706. PMID 1332768 DOI: 10.1021/Bi00162A005  0.316
1992 De Serrano VS, Sehl LC, Castellino FJ. Direct identification of lysine-33 as the principal cationic center of the omega-amino acid binding site of the recombinant kringle 2 domain of tissue-type plasminogen activator. Archives of Biochemistry and Biophysics. 292: 206-12. PMID 1309292 DOI: 10.1016/0003-9861(92)90069-9  0.324
1992 Zhang L, Jhingan A, Castellino F. Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity Blood. 80: 942-952. DOI: 10.1182/Blood.V80.4.942.Bloodjournal804942  0.304
1991 Zhang L, Castellino FJ. A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant. Biochemistry. 29: 10828-34. PMID 2125495 DOI: 10.1021/Bi00500A016  0.313
1991 Menhart N, Sehl LC, Kelley RF, Castellino FJ. Construction, expression, and purification of recombinant kringle 1 of human plasminogen and analysis of its interaction with omega-amino acids. Biochemistry. 30: 1948-57. PMID 1993205 DOI: 10.1021/Bi00221A031  0.319
1991 Davidson DJ, Castellino FJ. Oligosaccharide structures present on asparagine-289 of recombinant human plasminogen expressed in a Chinese hamster ovary cell line. Biochemistry. 30: 625-33. PMID 1899031 DOI: 10.1021/Bi00217A006  0.314
1991 Wu DW, Duman JG, Cheng CHC, Castellino FJ. Purification and characterization of antifreeze proteins from larvae of the beetle Dendroides canadensis Journal of Comparative Physiology B. 161: 271-278. DOI: 10.1007/Bf00262308  0.308
1990 Davidson DJ, Fraser MJ, Castellino FJ. Oligosaccharide processing in the expression of human plasminogen cDNA by lepidopteran insect (Spodoptera frugiperda) cells. Biochemistry. 29: 5584-90. PMID 2386787 DOI: 10.1021/Bi00475A024  0.32
1990 Davidson DJ, Higgins DL, Castellino FJ. Plasminogen activator activities of equimolar complexes of streptokinase with variant recombinant plasminogens. Biochemistry. 29: 3585-90. PMID 2141279 DOI: 10.1021/Bi00466A023  0.312
1990 Chibber BA, Urano S, Castellino FJ. Synthesis, purification, and properties of a peptide that enhances the activation of human [Glu1]plasminogen by tissue plasminogen activator and retards fibrin polymerization. International Journal of Peptide and Protein Research. 35: 73-80. PMID 1969852 DOI: 10.1111/J.1399-3011.1990.Tb00723.X  0.335
1989 Urano T, Sator de Serrano V, Gaffney PJ, Castellino FJ. Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator. Biochemistry. 27: 6522-8. PMID 3146348 DOI: 10.1021/Bi00417A049  0.318
1989 Radek JT, Castellino FJ. A differential scanning calorimetric investigation of the domains of recombinant tissue plasminogen activator. Archives of Biochemistry and Biophysics. 267: 776-86. PMID 3145719 DOI: 10.1016/0003-9861(88)90087-2  0.307
1989 Zhang L, Castellino FJ. Generation of an antibody with a designed specificity difference for protein C and activated protein C. Journal of Protein Chemistry. 8: 471-80. PMID 2803512 DOI: 10.1007/Bf01026431  0.303
1989 Whitefleet-Smith J, Rosen E, McLinden J, Ploplis VA, Fraser MJ, Tomlinson JE, McLean JW, Castellino FJ. Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system. Archives of Biochemistry and Biophysics. 271: 390-9. PMID 2658810 DOI: 10.1016/0003-9861(89)90288-9  0.568
1989 de Serrano VS, Urano T, Gaffney PJ, Castellino FJ. Influence of various structural domains of fibrinogen and fibrin on the potentiation of plasminogen activation by recombinant tissue plasminogen activator. Journal of Protein Chemistry. 8: 61-77. PMID 2527513 DOI: 10.1007/Bf01025079  0.332
1989 Urano S, Metzger AR, Castellino FJ. Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators. Proceedings of the National Academy of Sciences of the United States of America. 86: 2568-71. PMID 2523073 DOI: 10.1073/Pnas.86.8.2568  0.313
1989 Chi CW, Liu HZ, Liu CY, Chibber BA, Castellino FJ. The inhibition of the enzymic activity of blood coagulation and fibrinolytic serine proteases by a new leupeptin-like inhibitor, and its structural analogues, isolated from Streptomyces griseus. The Journal of Antibiotics. 42: 1506-12. PMID 2509406 DOI: 10.7164/Antibiotics.42.1506  0.325
1989 Urano T, deSerrano VS, Urano S, Castellino FJ. Stimulation by fibrinogen of the amidolytic activity of single-chain tissue plasminogen activator. Archives of Biochemistry and Biophysics. 270: 356-62. PMID 2494944 DOI: 10.1016/0003-9861(89)90038-6  0.308
1988 Castellino FJ, Beals JM. The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII. Journal of Molecular Evolution. 26: 358-69. PMID 3131537 DOI: 10.1007/Bf02101155  0.313
1988 Gaffney PJ, Urano T, de Serrano VS, Mahmoud-Alexandroni M, Metzger AR, Castellino FJ. Roles for chloride ion and fibrinogen in the activation of [Glu1]plasminogen in human plasma. Proceedings of the National Academy of Sciences of the United States of America. 85: 3595-8. PMID 3130631 DOI: 10.1073/Pnas.85.10.3595  0.316
1988 Castellino FJ, Urano T, de Serrano V, Morris JP, Chibber BA. Control of human plasminogen activation. Haemostasis. 18: 15-23. PMID 3127307 DOI: 10.1159/000215833  0.332
1988 Urano T, de Serrano VS, Gaffney PJ, Castellino FJ. The activation of human [Glu1]plasminogen by human single-chain urokinase. Archives of Biochemistry and Biophysics. 264: 222-30. PMID 2456035 DOI: 10.1016/0003-9861(88)90588-7  0.305
1988 Whitefleet-Smith J, Rosen E, Ploplis V, McLinden J, Castellino F. 24 Expression of a human plasminogen cDNA in an insect system Fibrinolysis. 2: 12. DOI: 10.1016/0268-9499(88)90049-5  0.525
1987 Hill KA, Castellino FJ. The binding of Mn2+ to bovine plasma protein C, des(1-41)-light chain protein C, and activated des(1-41)-light chain activated protein C. Archives of Biochemistry and Biophysics. 254: 196-202. PMID 3579297 DOI: 10.1016/0003-9861(87)90095-6  0.328
1987 Urano T, Chibber BA, Castellino FJ. The reciprocal effects of epsilon-aminohexanoic acid and chloride ion on the activation of human [Glu1]plasminogen by human urokinase. Proceedings of the National Academy of Sciences of the United States of America. 84: 4031-4. PMID 3473492 DOI: 10.1073/Pnas.84.12.4031  0.338
1987 Hill KAW, Castellino FJ. Topographical relationships among the monovalent cation binding sites of bovine plasma-activated protein C and des(1–41)-light-chain-activated bovine plasma protein C and a nitroxide spin label bound to their active site serine residues Journal of Protein Chemistry. 6: 489-495. DOI: 10.1007/Bf00276735  0.319
1986 Chibber BA, Radek JT, Morris JP, Castellino FJ. Rapid formation of an anion-sensitive active site in stoichiometric complexes of streptokinase and human [Glu1]plasminogen. Proceedings of the National Academy of Sciences of the United States of America. 83: 1237-41. PMID 3456584 DOI: 10.1073/Pnas.83.5.1237  0.311
1986 Powell JR, Beals JM, Castellino FJ. Secondary structure predictions of human plasminogen and the bovine prothrombin kringle loops. Archives of Biochemistry and Biophysics. 248: 390-400. PMID 2942111 DOI: 10.1016/0003-9861(86)90435-2  0.306
1985 Steiner SA, Castellino FJ. Kinetic mechanism for stimulation by monovalent cations of the amidase activity of the plasma protease bovine activated protein C. Biochemistry. 24: 609-17. PMID 2986681 DOI: 10.1021/Bi00324A011  0.315
1984 Cummings HS, Pizzo SV, Strickland DK, Castellino FJ. Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis. Biophysical Journal. 45: 721-4. PMID 6202335 DOI: 10.1016/S0006-3495(84)84214-9  0.488
1984 Cummings HS, Ploplis VA, Beals JM, Castellino FJ. Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen. Archives of Biochemistry and Biophysics. 230: 306-15. PMID 6201139 DOI: 10.1016/0003-9861(84)90112-7  0.531
1983 Powell JR, Castellino FJ. Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen. Biochemistry. 22: 923-7. PMID 6838832 DOI: 10.1021/Bi00273A033  0.317
1983 Morris JP, Castellino FJ. The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen. Biochimica Et Biophysica Acta. 744: 99-104. PMID 6219709 DOI: 10.1016/0167-4838(83)90345-X  0.328
1982 Powell JR, Castellino FJ. Isolation of human Val354 -plasminogen as an elastolytic fragment of human Glu1 -plasminogen. Biochemical and Biophysical Research Communications. 102: 46-52. PMID 7306166 DOI: 10.1016/0006-291X(81)91486-8  0.311
1982 Strickland DK, Morris JP, Castellino FJ. Enhancement of the streptokinase-catalyzed activation of human plasminogen by human fibrinogen and its plasminolysis products. Biochemistry. 21: 721-8. PMID 7200372 DOI: 10.1021/Bi00533A021  0.302
1982 Ploplis VA, Cummings HS, Castellino FJ. Monoclonal antibodies to discrete regions of human Glu1-plasminogen. Biochemistry. 21: 5891-7. PMID 6185142 DOI: 10.1021/Bi00266A025  0.514
1981 Ploplis VA, Strickland DK, Castellino FJ. Calorimetric evaluation of the existence of separate domains in bovine prothrombin. Biochemistry. 20: 15-21. PMID 7470466 DOI: 10.1021/Bi00504A003  0.521
1981 Strickland DK, Andersen TT, Hill RL, Castellino FJ. Calorimetric study of the rabbit hepatic galactoside binding protein: effects of calcium and ligands. Biochemistry. 20: 5294-7. PMID 7295681 DOI: 10.1021/Bi00521A031  0.502
1979 Castellino FJ, Violand BN. The fibrinolytic system--basic considerations. Progress in Cardiovascular Diseases. 21: 241-54. PMID 368879 DOI: 10.1016/0033-0620(79)90012-4  0.314
1979 Ploplis VA, Thomas JK, Castellino FJ. Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein. Chemistry and Physics of Lipids. 23: 49-62. PMID 221125 DOI: 10.1016/0009-3084(79)90022-7  0.519
1979 Prieels JP, Bell JE, Schindler M, Castellino FJ, Hill RL. Involvement of histidine-32 in the biological activity of alpha-lactalbumin. Biochemistry. 18: 1771-6. PMID 107966  0.394
1977 Castellino FJ, Thomas JK, Ploplis VA. Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein. Biochemical and Biophysical Research Communications. 75: 857-62. PMID 193504 DOI: 10.1016/0006-291X(77)91461-9  0.518
1975 Bell JE, Castellino FJ, Trayer IP, Hill RL. Modification of bovine alpha-lactalbumin with N-bromosuccinimide and 2-hydroxy-5-nitrobenzylbromide. The Journal of Biological Chemistry. 250: 7579-85. PMID 809437  0.632
1975 Castellino FJ, Schick LA, Brockway WJ, Sodetz JM. The activation and inhibition of fibrinolysis Advances in Experimental Medicine and Biology. 63: 233-243. PMID 128278 DOI: 10.1007/978-1-4684-3258-9_15  0.326
1975 Violand BN, Sodetz JM, Castellino FJ. The effect of ε{lunate}-amino caproic acid on the gross conformation of plasminogen and plasmin Archives of Biochemistry and Biophysics. 170: 300-305. PMID 126043 DOI: 10.1016/0003-9861(75)90121-6  0.343
1975 Hayes ML, Bretthauer RK, Castellino FJ. Carbohydrate compositions of the rabbit plasminogen isozymes. Archives of Biochemistry and Biophysics. 171: 651-5. PMID 967 DOI: 10.1016/0003-9861(75)90076-4  0.317
1974 Sodetz JM, Brockway WJ, Mann KG, Castellino FJ. The mechanism of activation of rabbit plasminogen by urokinase. Lack of a preactivation peptide Biochemical and Biophysical Research Communications. 60: 729-736. PMID 4278813 DOI: 10.1016/0006-291X(74)90301-5  0.326
1973 Hudson BG, Ono M, Brockway WJ, Castellino FJ. Chemical and physical properties of serum transferrins from several species. Biochemistry. 12: 1047-53. PMID 4734658 DOI: 10.1021/Bi00730A005  0.467
1972 Waterson RM, Castellino FJ, Hass GM, Hill RL. Purification and characterization of crotonase from Clostridium acetobutylicum. The Journal of Biological Chemistry. 247: 5266-71. PMID 5057466  0.371
1970 Brew K, Castellino FJ, Vanaman TC, Hill RL. The complete amino acid sequence of bovine alpha-lactalbumin. The Journal of Biological Chemistry. 245: 4570-82. PMID 5532231  0.71
1970 Castellino FJ, Hill RL. The carboxymethylation of bovine alpha-lactalbumin. The Journal of Biological Chemistry. 245: 417-24. PMID 5460891  0.363
1969 Castellino FJ, Barker R. The effect of guanidinium, carbamoylguanidinium, and guanylguanidinium salts on the solubility of benzoyl-L-tyrosine ethyl ester and acetyltetraglycine ethyl ester in water. Biochemistry. 8: 3439-42. PMID 5809234 DOI: 10.1021/Bi00836A046  0.434
1968 Castellino FJ, Barker R. The denaturing effectiveness of guanidinium, carbamoylguanidinium, and guanylguanidinium salts. Biochemistry. 7: 4135-8. PMID 5749177 DOI: 10.1021/Bi00851A049  0.436
1968 Castellino FJ, Barker R. Examination of the dissociation of multichain proteins in guanidine hydrochloride by membrane osmometry. Biochemistry. 7: 2207-17. PMID 5690713  0.382
1966 Castellino FJ, Barker R. The binding-sites of rabbit muscle aldolase. Biochemical and Biophysical Research Communications. 23: 182-7. PMID 5928910  0.391
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