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Francis J. Castellino - Publications

Affiliations: 
Chemistry and Biochemistry University of Notre Dame, Notre Dame, IN, United States 
Area:
blood coagulation and blood clot dissolution
Website:
http://chemistry.nd.edu/faculty/detail/fcastell/

306 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ayinuola YA, Brito-Robinson T, Ayinuola O, Beck JE, Cruz-Topete D, Lee SW, Ploplis VA, Castellino FJ. Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence. The Journal of Biological Chemistry. PMID 33208461 DOI: 10.1074/jbc.RA120.016262  1
2020 Charles J, Castellino FJ, Ploplis VA. Past and Present Behçet's Disease Animal Models. Current Drug Targets. PMID 32682369 DOI: 10.2174/1389450121666200719010425  1
2020 Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, et al. Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacology & Translational Science. 3: 418-424. PMID 32566907 DOI: 10.1021/acsptsci.0c00001  1
2020 Chen P, Liu R, Huang M, Zhu J, Wei D, Castellino FJ, Dang G, Xie F, Li G, Cui Z, Liu S, Zhang Y. A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans. The Journal of Biological Chemistry. PMID 32518157 DOI: 10.1074/jbc.RA119.011977  0.64
2020 Qiu C, Yuan Y, Lee SW, Ploplis VA, Castellino FJ. A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen. The Biochemical Journal. PMID 32270857 DOI: 10.1042/BCJ20200197  1
2020 Carothers KE, Liang Z, Mayfield J, Donahue DL, Lee M, Boggess B, Ploplis VA, Castellino FJ, Lee SW. The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen USA300 through cleavage of the Staphylococcal SdrC protein. Journal of Bacteriology. PMID 32205460 DOI: 10.1128/JB.00008-20  1
2020 Russo B, Ayinuola YA, Singh D, Carothers K, Fischetti VA, FloresMireles A, Lee SW, Ploplis VA, Liang Z, Castellino FJ. The M-protein of strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene. Journal of Bacteriology. PMID 32123038 DOI: 10.1128/JB.00096-20  1
2020 Andrews WT, Donahue D, Holmes A, Balsara R, Castellino FJ, Hummon AB. In situ metabolite and lipid analysis of GluN2D and wild-type mice after ischemic stroke using MALDI MSI. Analytical and Bioanalytical Chemistry. PMID 32107573 DOI: 10.1007/s00216-020-02477-z  0.52
2019 Liang Z, Carothers K, Holmes A, Donahue D, Lee SW, Castellino FJ, Ploplis VA. Stable genetic integration of a red fluorescent protein in a virulent Group A strain. Access Microbiology. 1: e000062. PMID 32974562 DOI: 10.1099/acmi.0.000062  1
2019 Ploplis VA, Castellino FJ. Host Pathways of Hemostasis that Regulate Group A Streptococcus Pyogenes Pathogenicity. Current Drug Targets. PMID 31556853 DOI: 10.2174/1389450120666190926152914  1
2019 Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ. Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis. Current Drug Targets. PMID 31309890 DOI: 10.2174/1389450120666190715102510  0.6
2019 Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ. Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. Journal of Structural Biology. PMID 31301349 DOI: 10.1016/j.jsb.2019.07.005  1
2019 Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP. Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. Journal of Molecular Biology. PMID 31295457 DOI: 10.1016/j.jmb.2019.07.003  0.72
2019 Walsh M, Moore EE, Moore H, Thomas S, Lune SV, Zimmer D, Dynako J, Hake D, Crowell Z, McCauley R, Larson EE, Miller M, Pohlman T, Achneck HE, Martin P, ... ... Castellino FJ, et al. Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review. Seminars in Thrombosis and Hemostasis. PMID 31108555 DOI: 10.1055/s-0039-1688497  1
2019 Ly D, Donahue D, Walker MJ, Ploplis VA, McArthur JD, Ranson M, Castellino FJ, Sanderson-Smith ML. Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection. PMID 31009808 DOI: 10.1016/j.micinf.2019.04.004  1
2019 Qiu C, Yuan Y, Liang Z, Lee SW, Ploplis VA, Castellino FJ. Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. Journal of Structural Biology. PMID 30880082 DOI: 10.1016/j.jsb.2019.03.003  1
2018 Qiu C, Yuan Y, Zajicek J, Liang Z, Balsara RD, Brito-Robionson T, Lee SW, Ploplis VA, Castellino FJ. Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization. Journal of Structural Biology. PMID 30071314 DOI: 10.1016/j.jsb.2018.07.017  1
2018 Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW. Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Skin Infection. Frontiers in Cellular and Infection Microbiology. 8: 211. PMID 30018884 DOI: 10.3389/fcimb.2018.00211  1
2018 Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ. Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia. Biomed Research International. 2018: 1878964. PMID 29977908 DOI: 10.1155/2018/1878964  1
2018 Liang Z, Stephens M, Ploplis VA, Lee SW, Castellino FJ. Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes. Genome Announcements. 6. PMID 29954901 DOI: 10.1128/genomeA.00592-18  1
2018 Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW. Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. The Journal of Antibiotics. PMID 29463889 DOI: 10.1038/s41429-018-0032-4  1
2017 Holmes A, Zhou N, Donahue DL, Balsara R, Castellino FJ. A deficiency of the GluN2C subunit of the N-Methyl-d-Aspartate receptor is neuroprotective in a mouse model of ischemic stroke. Biochemical and Biophysical Research Communications. PMID 29101031 DOI: 10.1016/j.bbrc.2017.10.171  0.8
2017 Yuan Y, Zajicek J, Qiu C, Chandrahas V, Lee SW, Ploplis VA, Castellino FJ. Conformationally Organized Lysine Isosteres in Streptococcus Pyogenes M Protein Mediate Direct High-Affinity Binding to Human Plasminogen. The Journal of Biological Chemistry. PMID 28724633 DOI: 10.1074/jbc.M117.794198  1
2017 Bao YJ, Li Y, Liang Z, Agrahari G, Lee SW, Ploplis VA, Castellino FJ. Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers. Pathogens and Disease. PMID 28520869 DOI: 10.1093/femspd/ftx056  1
2017 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Scientific Reports. 7: 365. PMID 28336948 DOI: 10.1038/s41598-017-00418-y  1
2017 Glinton K, Beck J, Liang Z, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Variable Region in Streptococcal M-Proteins Provides Stable Binding with Host Fibrinogen for Plasminogen-Mediated Bacterial Invasion. The Journal of Biological Chemistry. PMID 28280245 DOI: 10.1074/jbc.M116.768937  1
2017 Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinsek A, Lantry J, Sheppard F, ... Castellino F, et al. Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between". Seminars in Thrombosis and Hemostasis. PMID 28219085 DOI: 10.1055/s-0036-1597900  0.6
2016 Yuan Y, Balsara RD, Zajicek J, Kunda S, Castellino FJ. Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry. PMID 27981829 DOI: 10.1021/acs.biochem.6b00962  0.88
2016 Walsh M, Thomas S, Moore E, Moore H, Piscoya A, Hake D, Son M, Pohlman T, Wegner J, Bryant J, Grassetto A, Davis P, Nielsen N, Crepinsek A, Shreve JT, ... Castellino F, et al. Tranexamic Acid for Trauma Resuscitation in the United States of America. Seminars in Thrombosis and Hemostasis. PMID 27907937 DOI: 10.1055/s-0036-1586226  0.6
2016 Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ. Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps. Scientific Reports. 6: 36644. PMID 27821851 DOI: 10.1038/srep36644  1
2016 Higashi DL, Biais N, Donahue DL, Mayfield JA, Tessier CR, Rodriguez K, Ashfeld BL, Luchetti J, Ploplis VA, Castellino FJ, Lee SW. Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis. Nature Microbiology. 1: 15004. PMID 27571972 DOI: 10.1038/nmicrobiol.2015.4  1
2016 Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ. Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potentials for evolutionary persistence. Microbiology (Reading, England). PMID 27329479 DOI: 10.1099/mic.0.000326  1
2016 Gupta KK, Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through toll-like receptor-4. Biochemical and Biophysical Research Communications. PMID 27317488 DOI: 10.1016/j.bbrc.2016.06.065  1
2016 Mamczak CN, Maloney M, Fritz B, Boyer B, Thomas S, Evans E, Ploplis VA, Castellino FJ, McCollester J, Walsh M. Thromboelastography in Orthopaedic Trauma Pelvic Fracture Resuscitation: A Descriptive Pilot Study. Journal of Orthopaedic Trauma. PMID 27206253 DOI: 10.1097/BOT.0000000000000537  1
2016 Yasui H, Donahue DL, Walsh M, Castellino FJ, Ploplis VA. Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00429.2015. PMID 27190065 DOI: 10.1152/ajplung.00429.2015  1
2016 Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ. Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. Journal of Bacteriology. PMID 27044623 DOI: 10.1128/JB.01019-15  1
2016 Walsh M, Fritz S, Hake D, Son M, Greve S, Jbara M, Chitta S, Fritz B, Miller A, Bader MK, McCollester J, Binz S, Liew-Spilge A, Thomas S, Crepinsek A, ... ... Castellino FJ, et al. Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy. Current Drug Targets. PMID 26960340  0.6
2016 Agrahari G, Liang Z, Glinton K, Lee SW, Ploplis VA, Castellino FJ. Streptococcus pyogenes employs strain-dependent mechanisms of C3b inactivation to inhibit phagocytosis and killing of bacteria. The Journal of Biological Chemistry. PMID 26945067 DOI: 10.1074/jbc.M115.704221  1
2016 Cheriyan J, Balsara RD, Hansen KB, Castellino FJ. Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors. Neuroscience Letters. 617: 240-246. PMID 26917100 DOI: 10.1016/j.neulet.2016.02.032  0.88
2015 Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH. A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood. PMID 26647393 DOI: 10.1182/blood-2015-05-644260  0.4
2015 Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ. CovRS Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights on Virulence Determinants. Journal of Bacteriology. PMID 26216843 DOI: 10.1128/JB.00511-15  1
2015 Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ. Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein. The Journal of Biological Chemistry. 290: 18833-42. PMID 26070561 DOI: 10.1074/jbc.M115.655365  1
2015 Kunda S, Yuan Y, Balsara RD, Zajicek J, Castellino FJ. Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. The Journal of Biological Chemistry. 290: 18156-72. PMID 26048991 DOI: 10.1074/jbc.M115.650341  1
2015 Balsara R, Dang A, Donahue DL, Snow T, Castellino FJ. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke. Plos One. 10: e0122840. PMID 25822337 DOI: 10.1371/journal.pone.0122840  1
2015 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. Plos One. 10: e0120728. PMID 25799354 DOI: 10.1371/journal.pone.0120728  1
2015 Cheriyan J, Mezes C, Zhou N, Balsara RD, Castellino FJ. Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine. Biochemistry. 54: 787-94. PMID 25544544 DOI: 10.1021/bi501437s  1
2014 Balsara RD, Chapman SE, Sander IM, Donahue DL, Liepert L, Castellino FJ, Leevy WM. Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG. Journal of Visualized Experiments : Jove. PMID 25590998 DOI: 10.3791/51495  1
2014 Bao Y, Liang Z, Booyjzsen C, Mayfield JA, Li Y, Lee SW, Ploplis VA, Song H, Castellino FJ. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. Journal of Bacteriology. 196: 4089-102. PMID 25225265 DOI: 10.1128/JB.02131-14  1
2014 Huang L, Balsara RD, Castellino FJ. Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells. Journal of Neuroscience Research. 92: 1767-74. PMID 25043917 DOI: 10.1002/jnr.23447  1
2014 Mayfield JA, Liang Z, Agrahari G, Lee SW, Donahue DL, Ploplis VA, Castellino FJ. Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence. Plos One. 9: e100698. PMID 24968349 DOI: 10.1371/journal.pone.0100698  1
2014 Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ. Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain. The Journal of Biological Chemistry. 289: 21684-93. PMID 24962580 DOI: 10.1074/jbc.M114.570218  1
2014 Castellino FJ, Chapman MP, Donahue DL, Thomas S, Moore EE, Wohlauer MV, Fritz B, Yount R, Ploplis V, Davis P, Evans E, Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. The Journal of Trauma and Acute Care Surgery. 76: 1169-76. PMID 24747445 DOI: 10.1097/TA.0000000000000216  1
2014 Ploplis VA, Donahue DL, Sandoval-Cooper MJ, MorenoCaffaro M, Sheets P, Thomas SG, Walsh M, Castellino FJ. Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury. Journal of Neurotrauma. 31: 1672-5. PMID 24605991 DOI: 10.1089/neu.2013.3302  1
2014 Zhang Y, Mayfield JA, Ploplis VA, Castellino FJ. The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. Biochemical and Biophysical Research Communications. 444: 595-8. PMID 24486550 DOI: 10.1016/j.bbrc.2014.01.109  1
2014 Balsara RD, Ferreira AN, Donahue DL, Castellino FJ, Sheets PL. Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons. Neuropharmacology. 79: 542-9. PMID 24440368 DOI: 10.1016/j.neuropharm.2014.01.005  1
2014 Butera D, Wind T, Lay AJ, Beck J, Castellino FJ, Hogg PJ. Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. The Journal of Biological Chemistry. 289: 2992-3000. PMID 24338014 DOI: 10.1074/jbc.M113.539924  1
2014 Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. Journal of Thrombosis and Haemostasis : Jth. 12: 71-81. PMID 24175924 DOI: 10.1111/jth.12442  1
2014 Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. Journal of Neurotrauma. 31: 404-10. PMID 24040968 DOI: 10.1089/neu.2013.3089  1
2013 Kunda S, Cheriyan J, Hur M, Balsara RD, Castellino FJ. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. Plos One. 8: e81405. PMID 24260577 DOI: 10.1371/journal.pone.0081405  1
2013 Agrahari G, Liang Z, Mayfield JA, Balsara RD, Ploplis VA, Castellino FJ. Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. The Journal of Biological Chemistry. 288: 27494-504. PMID 23928307 DOI: 10.1074/jbc.M113.494864  1
2013 van Montfoort ML, Knaup VL, Marquart JA, Bakhtiari K, Castellino FJ, Hack CE, Meijers JC. Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. Thrombosis and Haemostasis. 110: 1065-73. PMID 23925504 DOI: 10.1160/TH13-05-0429  1
2013 Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. Plos Pathogens. 9: e1003469. PMID 23853591 DOI: 10.1371/journal.ppat.1003469  1
2013 Zhang Y, Liang Z, Glinton K, Ploplis VA, Castellino FJ. Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. Febs Letters. 587: 1304-9. PMID 23474243 DOI: 10.1016/j.febslet.2013.02.033  1
2013 Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ. A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. The Journal of Biological Chemistry. 288: 6561-73. PMID 23316057 DOI: 10.1074/jbc.M112.442657  1
2013 Davis PK, Musunuru H, Walsh M, Cassady R, Yount R, Losiniecki A, Moore EE, Wohlauer MV, Howard J, Ploplis VA, Castellino FJ, Thomas SG. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocritical Care. 18: 201-8. PMID 22847397 DOI: 10.1007/s12028-012-9745-6  1
2012 Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. Abnormal whole blood thrombi in humans with inherited platelet receptor defects. Plos One. 7: e52878. PMID 23300803 DOI: 10.1371/journal.pone.0052878  1
2012 Bhattacharya S, Ploplis VA, Castellino FJ. Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. Journal of Biomedicine & Biotechnology. 2012: 482096. PMID 23118509 DOI: 10.1155/2012/482096  1
2012 Zhang Y, Liang Z, Hsueh HT, Ploplis VA, Castellino FJ. Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. The Journal of Biological Chemistry. 287: 42093-103. PMID 23086939 DOI: 10.1074/jbc.M112.417808  1
2012 Narasaki R, Xu Z, Liang Z, Fung LC, Donahue D, Castellino FJ, Ploplis VA. The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. Journal of Thrombosis and Haemostasis : Jth. 10: 2618-21. PMID 23082983 DOI: 10.1111/jth.12032  1
2012 Davis PK, Musunuru H, Walsh M, Mitra R, Ploplis V, Castellino FJ. The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. Thrombosis and Haemostasis. 108: 586-8. PMID 22782135 DOI: 10.1160/TH12-04-0222  1
2012 Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. Journal of the American College of Surgeons. 214: 739-46. PMID 22520693 DOI: 10.1016/j.jamcollsurg.2012.01.050  1
2012 Balsara R, Li N, Weber-Adrian D, Huang L, Castellino FJ. Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology. 62: 2227-38. PMID 22306487 DOI: 10.1016/j.neuropharm.2012.01.018  1
2012 Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EG, Buckley SM, Waddington SN, McVey JH, Spence Y, Morton CL, Thrasher AJ, Gray JT, Castellino FJ, Tarantal AF, Davidoff AM, et al. AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood. 119: 957-66. PMID 22134170 DOI: 10.1182/blood-2011-09-377630  1
2011 Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ. Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. The Journal of Extra-Corporeal Technology. 43: 162-7. PMID 22164456  1
2011 Vetrano S, Ploplis VA, Sala E, Sandoval-Cooper M, Donahue DL, Correale C, Arena V, Spinelli A, Repici A, Malesci A, Castellino FJ, Danese S. Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 108: 19830-5. PMID 22109555 DOI: 10.1073/pnas.1107140108  1
2011 Guillen-Ahlers H, Tan J, Castellino FJ, Ploplis VA. Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29. Plos One. 6: e25725. PMID 21991341 DOI: 10.1371/journal.pone.0025725  1
2011 Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA. Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood. 118: 1653-62. PMID 21680799 DOI: 10.1182/blood-2010-11-316943  1
2011 Balsara RD, Merryman R, Virjee F, Northway C, Castellino FJ, Ploplis VA. A deficiency of uPAR alters endothelial angiogenic function and cell morphology. Vascular Cell. 3: 10. PMID 21535874 DOI: 10.1186/2045-824X-3-10  1
2011 Dai Q, Dong M, Liu Z, Prorok M, Castellino FJ. Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. Journal of Inorganic Biochemistry. 105: 52-7. PMID 21134602 DOI: 10.1016/j.jinorgbio.2010.10.002  1
2011 Cnudde SE, Prorok M, Jia X, Castellino FJ, Geiger JH. The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 257-66. PMID 21063741 DOI: 10.1007/s00775-010-0722-2  1
2011 Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M. An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood. 117: 283-9. PMID 20858853 DOI: 10.1182/blood-2010-07-299057  1
2011 Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality (Blood (2009) 113, 12 (2859-2866)) Blood. 117: 7188. DOI: 10.1182/blood-2011-05-354621  1
2010 Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. The Journal of Clinical Investigation. 120: 3167-78. PMID 20714108 DOI: 10.1172/JCI42629  1
2010 Sheng Z, Prorok M, Castellino FJ. Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors. Neuroscience. 170: 703-10. PMID 20688135 DOI: 10.1016/j.neuroscience.2010.07.056  1
2010 Wang M, Prorok M, Castellino FJ. NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain. Biophysical Journal. 99: 302-12. PMID 20655859 DOI: 10.1016/j.bpj.2010.04.019  1
2010 Iwaki T, Malinverno C, Smith D, Xu Z, Liang Z, Ploplis VA, Castellino FJ. The generation and characterization of mice expressing a plasmin-inactivating active site mutation. Journal of Thrombosis and Haemostasis : Jth. 8: 2341-4. PMID 20653841 DOI: 10.1111/j.1538-7836.2010.03995.x  1
2010 Huang L, Balsara RD, Sheng Z, Castellino FJ. Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation. Molecular and Cellular Neurosciences. 45: 163-72. PMID 20600930 DOI: 10.1016/j.mcn.2010.06.007  1
2010 Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. The Journal of Clinical Investigation. 120: 1971-80. PMID 20458145 DOI: 10.1172/JCI40380  1
2010 Xu Z, Xu H, Ploplis VA, Castellino FJ. Factor VII deficiency impairs cutaneous wound healing in mice. Molecular Medicine (Cambridge, Mass.). 16: 167-76. PMID 20454518 DOI: 10.2119/molmed.2009.00171  1
2010 Cnudde SE, Prorok M, Castellino FJ, Geiger JH. Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 667-75. PMID 20195692 DOI: 10.1007/s00775-010-0633-2  1
2010 Figuera-Losada M, Ranson M, Sanderson-Smith ML, Walker MJ, Castellino FJ, Prorok M. Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). Biochimica Et Biophysica Acta. 1804: 1342-9. PMID 20152941 DOI: 10.1016/j.bbapap.2010.01.019  1
2010 Guillen-Ahlers H, Suckow MA, Castellino FJ, Ploplis VA. Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. Plos One. 5: e9070. PMID 20140201 DOI: 10.1371/journal.pone.0009070  1
2010 Danese S, Vetrano S, Zhang L, Poplis VA, Castellino FJ. The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood. 115: 1121-30. PMID 20018912 DOI: 10.1182/blood-2009-09-201616  1
2010 Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood. 115: 2038-47. PMID 20009036 DOI: 10.1182/blood-2009-09-244962  1
2010 Wang M, Zajicek J, Geiger JH, Prorok M, Castellino FJ. Solution structure of the complex of VEK-30 and plasminogen kringle 2. Journal of Structural Biology. 169: 349-59. PMID 19800007 DOI: 10.1016/j.jsb.2009.09.011  1
2009 Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of Clinical Investigation. 119: 3437-49. PMID 19841542 DOI: 10.1172/JCI38476  1
2009 Battistel MD, Grishaev A, An SS, Castellino FJ, Llinás M. Solution structure and functional characterization of human plasminogen kringle 5. Biochemistry. 48: 10208-19. PMID 19821587 DOI: 10.1021/bi901433n  1
2009 Gutiérrez-Fernández A, Gingles NA, Bai H, Castellino FJ, Parmer RJ, Miles LA. Plasminogen enhances neuritogenesis on laminin-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12393-400. PMID 19812315 DOI: 10.1523/JNEUROSCI.3553-09.2009  1
2009 Waldemarsson J, Stålhammar-Carlemalm M, Sandin C, Castellino FJ, Lindahl G. Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence. Plos One. 4: e7279. PMID 19794915 DOI: 10.1371/journal.pone.0007279  1
2009 Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. Journal of Thrombosis and Haemostasis : Jth. 7: 140-5. PMID 19630787 DOI: 10.1111/j.1538-7836.2009.03410.x  1
2009 Dai Q, Xiao C, Dong M, Liu Z, Sheng Z, Castellino FJ, Prorok M. Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues. Peptides. 30: 866-72. PMID 19428763 DOI: 10.1016/j.peptides.2009.01.010  1
2009 Sheng Z, Liang Z, Geiger JH, Prorok M, Castellino FJ. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology. 57: 127-36. PMID 19427876 DOI: 10.1016/j.neuropharm.2009.04.014  1
2009 Shinagawa K, Ploplis VA, Castellino FJ. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 296: L763-70. PMID 19286924 DOI: 10.1152/ajplung.90638.2008  1
2009 Muralidharan-Chari V, Hoover H, Clancy J, Schweitzer J, Suckow MA, Schroeder V, Castellino FJ, Schorey JS, D'Souza-Schorey C. ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Research. 69: 2201-9. PMID 19276388 DOI: 10.1158/0008-5472.CAN-08-1301  1
2009 Tang H, Fu Y, Lei Q, Han Q, Ploplis VA, Castellino FJ, Li L, Luo Y. Fibrinogen facilitates the anti-tumor effect of nonnative endostatin. Biochemical and Biophysical Research Communications. 380: 249-53. PMID 19167351 DOI: 10.1016/j.bbrc.2009.01.045  1
2009 Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 113: 2859-66. PMID 19141861 DOI: 10.1182/blood-2008-12-192385  1
2009 Tang H, Fu Y, Cui Y, He Y, Zeng X, Ploplis VA, Castellino FJ, Luo Y. Fibrinogen has chaperone-like activity. Biochemical and Biophysical Research Communications. 378: 662-7. PMID 19059206 DOI: 10.1016/j.bbrc.2008.11.112  1
2009 Xu H, Noria F, Sandoval-Cooper MJ, Menchen H, Donahue DL, Ploplis VA, Castellino FJ. Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice. The Journal of Pathology. 217: 362-71. PMID 18973189 DOI: 10.1002/path.2454  1
2009 Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 25-33. PMID 18841163 DOI: 10.1038/jcbfm.2008.117  1
2008 Iwaki T, Castellino FJ. A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins. Cytotechnology. 57: 45-9. PMID 19003171 DOI: 10.1007/s10616-008-9129-0  1
2008 Xiao C, Huang Y, Dong M, Hu J, Hou S, Castellino FJ, Prorok M, Dai Q. NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins. Neuropeptides. 42: 601-9. PMID 18992939 DOI: 10.1016/j.npep.2008.09.003  1
2008 Iwaki T, Cruz-Topete D, Castellino FJ. A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice. Journal of Thrombosis and Haemostasis : Jth. 6: 1993-5. PMID 18761719 DOI: 10.1111/j.1538-7836.2008.03142.x  1
2008 Lay AJ, Northway CM, Donahue DL, Castellino FJ. Low levels of tissue factor rescue protein C-associated pregnancy failure in mice. Journal of Thrombosis and Haemostasis : Jth. 6: 1815-7. PMID 18647222 DOI: 10.1111/j.1538-7836.2008.03085.x  1
2008 Sheng Z, Prorok M, Brown BE, Castellino FJ. N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology. 55: 204-14. PMID 18602124 DOI: 10.1016/j.neuropharm.2008.05.016  1
2008 Iwaki T, Sandoval-Cooper MJ, Tenenhouse HS, Castellino FJ. A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. Journal of the American Society of Nephrology : Jasn. 19: 1753-62. PMID 18550648 DOI: 10.1681/ASN.2007121360  1
2008 Guillen-Ahlers H, Buechler SA, Suckow MA, Castellino FJ, Ploplis VA. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis. 29: 1421-7. PMID 18499699 DOI: 10.1093/carcin/bgn123  1
2008 Castellino FJ, Ploplis VA, Zhang L. gamma-Glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 446: 85-94. PMID 18373251 DOI: 10.1007/978-1-60327-084-7_6  1
2008 Green KA, Almholt K, Ploug M, Rønø B, Castellino FJ, Johnsen M, Bugge TH, Rømer J, Lund LR. Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. The Journal of Investigative Dermatology. 128: 2092-101. PMID 18337830 DOI: 10.1038/jid.2008.54  1
2008 Iwaki T, Ploplis VA, Castellino FJ. The hemostasis system in murine atherosclerosis. Current Drug Targets. 9: 229-38. PMID 18336242 DOI: 10.2174/138945008783755593  1
2008 Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ. The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. The Journal of Biological Chemistry. 283: 1580-7. PMID 18039665 DOI: 10.1074/jbc.M705063200  1
2008 Merkulov S, Zhang WM, Komar AA, Schmaier AH, Barnes E, Zhou Y, Lu X, Iwaki T, Castellino FJ, Luo G, McCrae KR. Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood. 111: 1274-81. PMID 18000168 DOI: 10.1182/blood-2007-06-092338  1
2008 Castellino FJ, Ploplis VA, Zhang L. γ-glutamate and β-hydroxyaspartate in proteins Methods in Molecular Biology. 446: 85-94. DOI: 10.1007/978-1-60327-84-7_6  1
2007 Ploplis VA, Tipton H, Menchen H, Castellino FJ. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. The Journal of Pathology. 213: 266-74. PMID 17893885 DOI: 10.1002/path.2236  1
2007 Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. The Journal of Experimental Medicine. 204: 2439-48. PMID 17893198 DOI: 10.1084/jem.20070404  1
2007 Bhatnagar S, Shinagawa K, Castellino FJ, Schorey JS. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood. 110: 3234-44. PMID 17666571 DOI: 10.1182/blood-2007-03-079152  1
2007 Sheng Z, Dai Q, Prorok M, Castellino FJ. Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides. Neuropharmacology. 53: 145-56. PMID 17588620 DOI: 10.1016/j.neuropharm.2007.04.016  1
2007 Prorok M, Castellino FJ. The molecular basis of conantokin antagonism of NMDA receptor function. Current Drug Targets. 8: 633-42. PMID 17504106 DOI: 10.2174/138945007780618481  1
2007 Dai Q, Sheng Z, Geiger JH, Castellino FJ, Prorok M. Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives. The Journal of Biological Chemistry. 282: 12641-9. PMID 17347154 DOI: 10.1074/jbc.M609087200  1
2007 Cnudde SE, Prorok M, Dai Q, Castellino FJ, Geiger JH. The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. Journal of the American Chemical Society. 129: 1586-93. PMID 17243678 DOI: 10.1021/ja065722q  1
2007 Iwaki T, Donahue DL, Castellino FJ. High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice. Journal of Thrombosis and Haemostasis : Jth. 5: 624-6. PMID 17155952 DOI: 10.1111/j.1538-7836.2006.02358.x  1
2007 Shinagawa K, Martin JA, Ploplis VA, Castellino FJ. Coagulation factor Xa modulates airway remodeling in a murine model of asthma. American Journal of Respiratory and Critical Care Medicine. 175: 136-43. PMID 17082493 DOI: 10.1164/rccm.200608-1097OC  1
2007 Lay AJ, Donahue D, Tsai MJ, Castellino FJ. Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood. 109: 1984-91. PMID 17047151 DOI: 10.1182/blood-2006-07-037945  1
2007 Iwaki T, Donahue DL, Castellino FJ. High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice [6] Journal of Thrombosis and Haemostasis. 5: 624-626. DOI: 10.1111/j.1538-7836.2007.02358.x  1
2006 Castellino FJ, Ganopolsky JG, Noria F, Sandoval-Cooper MJ, Ploplis VA. Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene. Thrombosis and Haemostasis. 96: 794-801. PMID 17139375 DOI: 10.1160/TH06-08-0430  1
2006 Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. The Journal of Pathology. 210: 488-96. PMID 17054310 DOI: 10.1002/path.2073  1
2006 Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ. Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice. The Journal of Pathology. 210: 325-33. PMID 16981239 DOI: 10.1002/path.2060  1
2006 Cnudde SE, Prorok M, Castellino FJ, Geiger JH. X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM. Biochemistry. 45: 11052-60. PMID 16964966 DOI: 10.1021/bi060914j  1
2006 Green KA, Nielsen BS, Castellino FJ, Rømer J, Lund LR. Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Developmental Biology. 299: 164-75. PMID 16949567 DOI: 10.1016/j.ydbio.2006.07.021  1
2006 Wei J, Dong M, Xiao C, Jiang F, Castellino FJ, Prorok M, Dai Q. Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. Neuroscience Letters. 405: 137-41. PMID 16859831 DOI: 10.1016/j.neulet.2006.06.040  1
2006 Balsara RD, Castellino FJ, Ploplis VA. A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. The Journal of Biological Chemistry. 281: 22527-36. PMID 16785241 DOI: 10.1074/jbc.M512819200  1
2006 Iwaki T, Castellino FJ. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thrombosis and Haemostasis. 95: 1003-10. PMID 16732380 DOI: 10.1160/TH06-03-0128  1
2006 Mitchell JW, Baik N, Castellino FJ, Miles LA. Plasminogen inhibits TNFalpha-induced apoptosis in monocytes. Blood. 107: 4383-90. PMID 16478887 DOI: 10.1182/blood-2005-07-2872  1
2006 Iwaki T, Sandoval-Cooper MJ, Brechmann M, Ploplis VA, Castellino FJ. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood. 107: 3883-91. PMID 16434491 DOI: 10.1182/blood-2005-09-3780  1
2006 Busquets L, Guillen H, DeFord ME, Suckow MA, Navari RM, Castellino FJ, Prorok M. Cathepsin E is a specific marker of dysplasia in APC mouse intestine. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 27: 36-42. PMID 16340248 DOI: 10.1159/000090154  1
2005 Gutierrez LS, Noria F, Finol H, Sun L, Castellino F, Pollard M. Fas ligand expression and its correlation with apoptosis and proliferation in Lobund-Wistar prostate carcinomas. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology. 72: 260-8. PMID 16374070 DOI: 10.1159/000089420  0.8
2005 Suckow MA, Zollman A, Cornelissen I, Casad M, Roahrig J, Castellino FJ, Rosen ED. Tissue distribution of fetal liver cells following in utero transplantation in mice. Experimental Biology and Medicine (Maywood, N.J.). 230: 860-4. PMID 16339751  1
2005 Rosen ED, Xu H, Liang Z, Martin JA, Suckow M, Castellino FJ. Generation of genetically-altered mice producing very low levels of coagulation factorVII. Thrombosis and Haemostasis. 94: 493-7. PMID 16268461 DOI: 10.1160/TH05-05-0337  1
2005 Dai Q, Prorok M, Castellino FJ. Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties. Biochemistry. 44: 12508-14. PMID 16156662 DOI: 10.1021/bi050974+  1
2005 Iwaki T, Castellino FJ. Maternal fibrinogen is necessary for embryonic development. Current Drug Targets. 6: 535-9. PMID 16026273 DOI: 10.2174/1389450054546006  1
2005 Lay AJ, Liang Z, Rosen ED, Castellino FJ. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. The Journal of Clinical Investigation. 115: 1552-61. PMID 15902301 DOI: 10.1172/JCI24030  1
2005 Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system. Thrombosis and Haemostasis. 93: 647-54. PMID 15841308 DOI: 10.1267/THRO05040647  1
2005 Miles LA, Hawley SB, Baik N, Andronicos NM, Castellino FJ, Parmer RJ. Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Frontiers in Bioscience : a Journal and Virtual Library. 10: 1754-62. PMID 15769664  1
2005 Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Gröger M, Wolff K, Zacharowski K. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nature Medicine. 11: 298-304. PMID 15723073 DOI: 10.1038/nm1198  1
2005 Iwaki T, Cruz DT, Martin JA, Castellino FJ. A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood. 105: 2364-71. PMID 15528312 DOI: 10.1182/blood-2004-06-2456  1
2004 Yang R, Prorok M, Castellino FJ, Weliky DP. A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. Journal of the American Chemical Society. 126: 14722-3. PMID 15535688 DOI: 10.1021/ja045612o  1
2004 Dai Q, Castellino FJ, Prorok M. A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. Biochemistry. 43: 13225-32. PMID 15476416 DOI: 10.1021/bi048796s  1
2004 Ganopolsky JG, Castellino FJ. A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. The American Journal of Pathology. 165: 1433-46. PMID 15466407 DOI: 10.1016/S0002-9440(10)63401-3  1
2004 Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF. A central role for plasminogen in the inflammatory response to biomaterials. Journal of Thrombosis and Haemostasis : Jth. 2: 1798-805. PMID 15456492 DOI: 10.1111/j.1538-7836.2004.00916.x  1
2004 Yang J, Prorok M, Castellino FJ, Weliky DP. Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers. Biophysical Journal. 87: 1951-63. PMID 15345571 DOI: 10.1529/biophysj.103.028530  1
2004 Suckow MA, Gutierrez LS, Risatti CA, Wolter WR, Taylor RE, Pollard M, Navari RM, Castellino FJ, Paoni NF. The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice. Cancer Letters. 209: 165-9. PMID 15159018 DOI: 10.1016/j.canlet.2004.01.007  1
2004 Dai Q, Prorok M, Castellino FJ. A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. Journal of Molecular Biology. 336: 731-44. PMID 15095984 DOI: 10.1016/j.jmb.2003.12.027  1
2004 Sazonova IY, Robinson BR, Gladysheva IP, Castellino FJ, Reed GL. alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator. The Journal of Biological Chemistry. 279: 24994-5001. PMID 15069059 DOI: 10.1074/jbc.M400253200  1
2004 Xu Z, Balsara RD, Gorlatova NV, Lawrence DA, Castellino FJ, Ploplis VA. Conservation of critical functional domains in murine plasminogen activator inhibitor-1. The Journal of Biological Chemistry. 279: 17914-20. PMID 14963029 DOI: 10.1074/jbc.M314197200  1
2004 Ploplis VA, Balsara R, Sandoval-Cooper MJ, Yin ZJ, Batten J, Modi N, Gadoua D, Donahue D, Martin JA, Castellino FJ. Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. The Journal of Biological Chemistry. 279: 6143-51. PMID 14625301 DOI: 10.1074/jbc.M307297200  1
2003 Urano T, Castellino FJ, Ihara H, Suzuki Y, Ohta M, Suzuki K, Mogami H. Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1. Journal of Thrombosis and Haemostasis : Jth. 1: 2615-20. PMID 14675098 DOI: 10.1046/j.1538-7836.2003.00443.x  1
2003 Dai Q, Zajicek J, Castellino FJ, Prorok M. Binding and orientation of conantokins in PL vesicles and aligned PL multilayers. Biochemistry. 42: 12511-21. PMID 14580197 DOI: 10.1021/bi034918p  1
2003 Iwaki T, Figuera M, Ploplis VA, Castellino FJ. Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques. 35: 482-4, 486. PMID 14513552  1
2003 Paoni NF, Feldman MW, Gutierrez LS, Ploplis VA, Castellino FJ. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiological Genomics. 15: 228-35. PMID 13130079 DOI: 10.1152/physiolgenomics.00078.2003  1
2003 Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. The American Journal of Pathology. 163: 517-31. PMID 12875972 DOI: 10.1016/S0002-9440(10)63680-2  1
2003 Rosen ED, Cornelissen I, Liang Z, Zollman A, Casad M, Roahrig J, Suckow M, Castellino FJ. In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses. Journal of Thrombosis and Haemostasis : Jth. 1: 19-27. PMID 12871535 DOI: 10.1046/j.1538-7836.2003.00030.x  1
2003 Zhang L, Gong Y, Grella DK, Castellino FJ, Miles LA. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface. Journal of Thrombosis and Haemostasis : Jth. 1: 1264-70. PMID 12871329 DOI: 10.1046/j.1538-7836.2003.00155.x  1
2003 Klein RC, Prorok M, Castellino FJ. Direct binding properties of conantokins to native N-methyl-d-aspartate receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 307-17. PMID 12753378 DOI: 10.1034/j.1399-3011.2003.00059.x  1
2003 Mundada LV, Prorok M, DeFord ME, Figuera M, Castellino FJ, Fay WP. Structure-function analysis of the streptokinase amino terminus (residues 1-59). The Journal of Biological Chemistry. 278: 24421-7. PMID 12704199 DOI: 10.1074/jbc.M301825200  1
2003 Wu SC, Castellino FJ, Wong SL. A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy. The Journal of Biological Chemistry. 278: 18199-206. PMID 12646571 DOI: 10.1074/jbc.M210919200  1
2003 Gutierrez LS, Suckow M, Lawler J, Ploplis VA, Castellino FJ. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 24: 199-207. PMID 12584168 DOI: 10.1093/carcin/24.2.199  1
2003 Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine. 9: 338-42. PMID 12563316 DOI: 10.1038/nm826  1
2003 Miles LA, Castellino FJ, Gong Y. Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends in Cardiovascular Medicine. 13: 21-30. PMID 12554097 DOI: 10.1016/S1050-1738(02)00190-1  1
2002 Castellino FJ, Liang Z, Volkir SP, Haalboom E, Martin JA, Sandoval-Cooper MJ, Rosen ED. Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. Thrombosis and Haemostasis. 88: 462-72. PMID 12353077 DOI: 10.1267/THRO88030462  1
2002 Castellino FJ, Ellison EH. Use of phospholipid bilayers and monolayers in binding studies of vitamin K-dependent blood coagulation proteins. Methods in Molecular Biology (Clifton, N.J.). 199: 233-43. PMID 12094573 DOI: 10.1385/1-59259-175-2:233  1
2002 Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH. The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. Journal of Molecular Biology. 318: 1009-17. PMID 12054798 DOI: 10.1016/S0022-2836(02)00211-5  1
2002 Castellino FJ, Ploplis VA, Zhang L. gamma-glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 194: 259-68. PMID 12029840 DOI: 10.1385/1-59259-181-7:259  1
2002 Rosen ED, Gailani D, Castellino FJ. FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. Thrombosis and Haemostasis. 87: 774-6. PMID 12008966  1
2002 Iwaki T, Sandoval-Cooper MJ, Paiva M, Kobayashi T, Ploplis VA, Castellino FJ. Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. The American Journal of Pathology. 160: 1021-34. PMID 11891199 DOI: 10.1016/S0002-9440(10)64923-1  1
2002 Ploplis VA, Castellino FJ. Gene targeting of components of the fibrinolytic system. Thrombosis and Haemostasis. 87: 22-31. PMID 11848453  1
2001 Loy JA, Lin X, Schenone M, Castellino FJ, Zhang XC, Tang J. Domain interactions between streptokinase and human plasminogen. Biochemistry. 40: 14686-95. PMID 11724583 DOI: 10.1021/bi011309d  1
2001 Chan JC, Duszczyszyn DA, Castellino FJ, Ploplis VA. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. The American Journal of Pathology. 159: 1681-8. PMID 11696429 DOI: 10.1016/S0002-9440(10)63015-5  1
2001 Klein RC, Warder SE, Galdzicki Z, Castellino FJ, Prorok M. Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides. Neuropharmacology. 41: 801-10. PMID 11684144 DOI: 10.1016/S0028-3908(01)00119-8  1
2001 Klein RC, Castellino FJ. Activators and inhibitors of the ion channel of the NMDA receptor. Current Drug Targets. 2: 323-9. PMID 11554556 DOI: 10.2174/1389450013348290  1
2001 Prorok M, Castellino FJ. Structure-function relationships of the NMDA receptor antagonist conantokin peptides. Current Drug Targets. 2: 313-22. PMID 11554555 DOI: 10.2174/1389450013348542  1
2001 Wilberding JA, Ploplis VA, McLennan L, Liang Z, Cornelissen I, Feldman M, Deford ME, Rosen ED, Castellino FJ. Development of pulmonary fibrosis in fibrinogen-deficient mice. Annals of the New York Academy of Sciences. 936: 542-8. PMID 11460513  1
2001 Ploplis VA, Castellino FJ. Attenuation of neointima formation following arterial injury in PAI-1 deficient mice. Annals of the New York Academy of Sciences. 936: 466-8. PMID 11460504  1
2001 Castellino FJ. Gene targeting in hemostasis: protein C. Frontiers in Bioscience : a Journal and Virtual Library. 6: D807-19. PMID 11438441  1
2001 Rios-Steiner JL, Schenone M, Mochalkin I, Tulinsky A, Castellino FJ. Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. Journal of Molecular Biology. 308: 705-19. PMID 11350170 DOI: 10.1006/jmbi.2001.4646  1
2001 Rosen ED, Raymond S, Zollman A, Noria F, Sandoval-Cooper M, Shulman A, Merz JL, Castellino FJ. Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombi. The American Journal of Pathology. 158: 1613-22. PMID 11337359 DOI: 10.1016/S0002-9440(10)64117-X  1
2001 Klein RC, Prorok M, Galdzicki Z, Castellino FJ. The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 276: 26860-7. PMID 11335724 DOI: 10.1074/jbc.M102428200  1
2001 Warder SE, Blandl T, Klein RC, Castellino FJ, Prorok M. Amino acid determinants for NMDA receptor inhibition by conantokin-T. Journal of Neurochemistry. 77: 812-22. PMID 11331410 DOI: 10.1046/j.1471-4159.2001.00281.x  1
2001 Gong Y, Kim SO, Felez J, Grella DK, Castellino FJ, Miles LA. Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. The Journal of Biological Chemistry. 276: 19078-83. PMID 11264290 DOI: 10.1074/jbc.M101387200  1
2001 Klein RC, Siarey RJ, Caruso A, Rapoport SI, Castellino FJ, Galdzicki Z. Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons. Journal of Neurochemistry. 76: 1663-9. PMID 11259484 DOI: 10.1046/j.1471-4159.2001.00170.x  1
2001 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ. The characterization of mice with a targeted combined deficiency of protein c and factor XI. The American Journal of Pathology. 158: 469-79. PMID 11159184 DOI: 10.1016/S0002-9440(10)63989-2  1
2001 Ploplis VA, Cornelissen I, Sandoval-Cooper MJ, Weeks L, Noria FA, Castellino FJ. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. The American Journal of Pathology. 158: 107-17. PMID 11141484 DOI: 10.1016/S0002-9440(10)63949-1  1
2001 Blandl T, Zajicek J, Prorok M, Castellino FJ. Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R. The Journal of Biological Chemistry. 276: 7391-6. PMID 11096077 DOI: 10.1074/jbc.M006648200  1
2001 Castellino FJ. Preface Current Drug Targets. 2: xxx.  1
2000 Castellino FJ, Prorok M. Conantokins: inhibitors of ion flow through the N-methyl-D-aspartate receptor channels. Current Drug Targets. 1: 219-35. PMID 11465072  1
2000 Wilberding JA, Castellino FJ. Characterization of the murine coagulation factor X promoter. Thrombosis and Haemostasis. 84: 1031-8. PMID 11154110  1
2000 Schenone MM, Warder SE, Martin JA, Prorok M, Castellino FJ. An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 438-45. PMID 11152303 DOI: 10.1034/j.1399-3011.2000.00810.x  1
2000 Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ. Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Research. 60: 5839-47. PMID 11059781  1
2000 Ploplis VA, Wilberding J, McLennan L, Liang Z, Cornelissen I, DeFord ME, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. The American Journal of Pathology. 157: 703-8. PMID 10980108 DOI: 10.1016/S0002-9440(10)64582-8  1
2000 Zajicek J, Chang Y, Castellino FJ. The effects of ligand binding on the backbone dynamics of the kringle 1 domain of human plasminogen Journal of Molecular Biology. 301: 333-347. PMID 10926513 DOI: 10.1006/jmbi.2000.3972  1
2000 Cooper A, Liang Z, Castellino FJ, Rosen ED. Cloning and characterization of the murine coagulation factor X gene Thrombosis and Haemostasis. 83: 732-735. PMID 10823271  1
2000 Ploplis VA, Castellino FJ. Nonfibrinolytic functions of plasminogen. Methods (San Diego, Calif.). 21: 103-10. PMID 10816371 DOI: 10.1006/meth.2000.0981  1
2000 Chan JC, Cornelissen I, Collen D, Ploplis VA, Castellino FJ. Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. The Journal of Clinical Investigation. 105: 897-903. PMID 10749569 DOI: 10.1172/JCI9095  1
2000 Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino FJ, Collen D, Rosen ED. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice Thrombosis and Haemostasis. 83: 185-190. PMID 10739370  1
2000 Blandl T, Warder SE, Prorok M, Castellino FJ. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. Febs Letters. 470: 139-46. PMID 10734223 DOI: 10.1016/S0014-5793(00)01309-0  1
2000 Schenone MM, Warder SE, Martin JA, Prokok M, Castellino FJ. Binding of RAM-derived peptides to the recombinant kringle 2 domain of human plasminogen Fibrinolysis and Proteolysis. 14: 23.  1
2000 Ploplis VA, Cornelissen I, Paul C, Sandoval-Cooper M, Castellino FJ. Two novel vascular injury models demonstrate a role for urokinase in early vascular repair events Fibrinolysis and Proteolysis. 14: 20.  1
2000 Ploplis VA, Wilberding J, Cornelissen I, Defokdm E, Uang Z, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice Fibrinolysis and Proteolysis. 14: 11.  1
1999 Klein RC, Galdzicki Z, Castellino FJ. Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology. 38: 1819-29. PMID 10608277 DOI: 10.1016/S0028-3908(99)00065-9  1
1999 Bretthauer RK, Castellino FJ. Glycosylation of Pichia pastoris-derived proteins. Biotechnology and Applied Biochemistry. 30: 193-200. PMID 10574687  1
1999 Klein RC, Castellino FJ. Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T. Neuroscience Letters. 273: 171-4. PMID 10515186 DOI: 10.1016/S0304-3940(99)00649-7  1
1999 Nilsen SL, Prorok M, Castellino FJ. Enhancement through mutagenesis of the binding of the isolated kringle 2 domain of human plasminogen to ω-amino acid ligands and to an internal sequence of a Streptococcal surface protein Journal of Biological Chemistry. 274: 22380-22386. PMID 10428809 DOI: 10.1074/jbc.274.32.22380  1
1999 Chang Y, Nilsen SL, Castellino FJ. Functional and structural consequences of aromatic residue substitutions within the kringle-2 domain of tissue-type plasminogen activator Journal of Peptide Research. 53: 656-664. PMID 10408340 DOI: 10.1034/j.1399-3011.1999.00078.x  1
1999 Blandl T, Warder SE, Prorok M, Castellino FJ. Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 453-64. PMID 10406223 DOI: 10.1034/j.1399-3011.1999.00042.x  1
1999 Nilsen SL, Castellino FJ. Expression of human plasminogen in Drosophila Schneider S2 cells Protein Expression and Purification. 16: 136-143. PMID 10336871 DOI: 10.1006/prep.1999.1045  1
1999 Liang Z, Rosen ED, Castellino FJ. Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor Thrombosis and Haemostasis. 81: 585-588. PMID 10235444  1
1999 Miele RG, Prorok M, Costa VA, Castellino FJ. Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity. The Journal of Biological Chemistry. 274: 7769-76. PMID 10075668 DOI: 10.1074/jbc.274.12.7769  1
1999 Chan JCY, Carmeliet P, Moons L, Rosen ED, Huang ZF, Broze GJ, Collen D, Castellino FJ. Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit Journal of Clinical Investigation. 103: 475-482. PMID 10021455  1
1998 Weidong-Richard JI, Castellino FJ, Chang Y, Deford ME, Gray H, Villarreal X, Kondri ME, Marti DN, Llinás M, Schaller J, Kramer RA, Trail PA. Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis Faseb Journal. 12: 1731-1738. PMID 9837863  1
1998 Jalbert LR, Rosen ED, Moons L, Chan JCY, Carmeliet P, Collen D, Castellino FJ. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice Journal of Clinical Investigation. 102: 1481-1488. PMID 9788960  1
1998 Blandl T, Prorok M, Castellino FJ. NMDA-receptor antagonist requirements in conantokin-G. Febs Letters. 435: 257-62. PMID 9762921 DOI: 10.1016/S0014-5793(98)01077-1  1
1998 Liang Z, Cooper A, Rosen ED, Castellino FJ. Chromosomal arrangement of the murine coagulation factor VII and factor X genes [6] Thrombosis and Haemostasis. 80: 524-525. PMID 9759642  1
1998 Wistedt AC, Kotarsky H, Marti D, Ringdahl U, Castellino FJ, Schaller J, Sjöbring U. Kringle 2 mediates high affinity binding of plasminogen to an internal sequence in streptococcal surface protein PAM Journal of Biological Chemistry. 273: 24420-24424. PMID 9733732 DOI: 10.1074/jbc.273.38.24420  1
1998 Duman JG, Miele RG, Liang H, Grella DK, Sim KL, Castellino FJ, Bretthauer RK. O-Mannosylation of Pichia pastoris cellular and recombinant proteins. Biotechnology and Applied Biochemistry. 28: 39-45. PMID 9693087  1
1998 Liang Z, Cooper A, DeFord ME, Carmeliet P, Collen D, Castellino FJ, Rosen ED. Cloning and characterization of a cDNA encoding murine coagulation factor X Thrombosis and Haemostasis. 80: 87-91. PMID 9684791  1
1998 Prorok M, Castellino FJ. Thermodynamics of binding of calcium, magnesium, and zinc to the N- methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T Journal of Biological Chemistry. 273: 19573-19578. PMID 9677382 DOI: 10.1074/jbc.273.31.19573  1
1998 Ji WR, Barrientos LG, Llinás M, Gray H, Villarreal X, Deford ME, Castellino FJ, Kramer RA, Trail PA. Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis Biochemical and Biophysical Research Communications. 247: 414-419. PMID 9642142 DOI: 10.1006/bbrc.1998.8825  1
1998 Chen Z, Blandl T, Prorok M, Warder SE, Li L, Zhu Y, Pedersen LG, Ni F, Castellino FJ. Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis. The Journal of Biological Chemistry. 273: 16248-58. PMID 9632684 DOI: 10.1074/jbc.273.26.16248  1
1998 Ellison EH, Castellino FJ. Adsorption of vitamin K-dependent blood coagulation proteins to spread phospholipid monolayers as determined from combined measurements of the surface pressure and surface protein concentration Biochemistry. 37: 7997-8003. PMID 9609692 DOI: 10.1021/bi973118+  1
1998 Li N, Chibber BA, Castellino FJ, Duman JG. Mapping of disulfide bridges in antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis. Biochemistry. 37: 6343-50. PMID 9572849 DOI: 10.1021/bi972853i  1
1998 Chang Y, Mochalkin I, McCance SG, Cheng B, Tulinsky A, Castellino FJ. Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. Biochemistry. 37: 3258-71. PMID 9521645 DOI: 10.1021/bi972284e  1
1998 Warder SE, Prorok M, Chen Z, Li L, Zhu Y, Pedersen LG, Ni F, Castellino FJ. The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T. The Journal of Biological Chemistry. 273: 7512-22. PMID 9516452 DOI: 10.1074/jbc.273.13.7512  1
1998 Stauffer DR, Chukwumezie BN, Wilberding JA, Rosen ED, Castellino FJ. Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene Journal of Biological Chemistry. 273: 2277-2287. PMID 9442072 DOI: 10.1074/jbc.273.4.2277  1
1997 Blandl T, Zajicek J, Prorok M, Castellino FJ. Metal-ion-binding properties of synthetic conantokin-G. The Biochemical Journal. 328: 777-83. PMID 9396720  1
1997 Rosen ED, Chan JCY, Idusogie E, Clotman F, Vlasuk G, Luther T, Jalbert LR, Albrecht S, Zhong L, Lissens A, Schoonjans L, Moons L, Collen D, Castellino FJ, Carmeliet P. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding Nature. 390: 290-294. PMID 9384381 DOI: 10.1038/36862  1
1997 Miele RG, Castellino FJ, Bretthauer RK. Characterization of the acidic oligosaccharides assembled on the Pichia pastoris-expressed recombinant kringle 2 domain of human tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 26: 79-83. PMID 9357103  1
1997 Warder SE, Chen Z, Zhu Y, Prorok M, Castellino FJ, Ni F. The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions. Febs Letters. 411: 19-26. PMID 9247135 DOI: 10.1016/S0014-5793(97)00573-5  1
1997 Ren J, Castellino FJ, Bretthauer RK. Purification and properties of alpha-mannosidase II from Golgi-like membranes of baculovirus-infected Spodoptera frugiperda (IPLB-SF-21AE) cells. The Biochemical Journal. 324: 951-6. PMID 9210421 DOI: 10.1042/bj3240951  1
1997 Wang H, Prorok M, Bretthauer RK, Castellino FJ. Serine-578 is a major phosphorylation locus in human plasma plasminogen. Biochemistry. 36: 8100-6. PMID 9201958 DOI: 10.1021/bi970328d  1
1997 Miele RG, Nilsen SL, Brito T, Bretthauer RK, Castellino FJ. Glycosylation properties of the Pichia pastoris-expressed recombinant kringle 2 domain of tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 25: 151-7. PMID 9127488  1
1997 Nilsen SL, DeFord ME, Prorok M, Chibber BA, Bretthauer RK, Castellino FJ. High-level secretion in Pichia pastoris and biochemical characterization of the recombinant kringle 2 domain of tissue-type plasminogen activator. Biotechnology and Applied Biochemistry. 25: 63-74. PMID 9032937 DOI: 10.1111/j.1470-8744.1997.tb00415.x  1
1996 Prorok M, Warder SE, Blandl T, Castellino FJ. Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail "sleeper" peptides, conantokin-G and conantokin-T. Biochemistry. 35: 16528-34. PMID 8987986 DOI: 10.1021/bi9621122  1
1996 Prorok M, Geng JP, Warder SE, Castellino FJ. The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor. International Journal of Peptide and Protein Research. 48: 281-5. PMID 8897096  1
1996 Jalbert LR, Chan JCY, Christiansen WT, Castellino FJ. The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles Biochemistry. 35: 7093-7099. PMID 8679535 DOI: 10.1021/bi960290p  1
1996 Mathews II, Vanderhoff-Hanaver P, Castellino FJ, Tulinsky A. Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Biochemistry. 35: 2567-76. PMID 8611560 DOI: 10.1021/bi9521351  1
1995 Menhart N, Castellino FJ. The importance of the hydrophobic components of the binding energies in the interaction of ω-amino acid ligands with isolated kringle polypeptide domains of human plasminogen International Journal of Peptide and Protein Research. 46: 464-470. PMID 8748706 DOI: 10.1111/j.1399-3011.1995.tb01601.x  1
1995 Ren J, Bretthauer RK, Castellino FJ. Purification and properties of a Golgi-derived (alpha 1,2)-mannosidase-I from baculovirus-infected lepidopteran insect cells (IPLB-SF21AE) with preferential activity toward mannose6-N-acetylglucosamine2. Biochemistry. 34: 2489-95. PMID 7873528 DOI: 10.1021/bi00008a012  0.4
1995 Menhart N, Hoover GJ, McCance SG, Castellino FJ. Roles of individual kringle domains in the functioning of positive and negative effectors of human plasminogen activation Biochemistry. 34: 1482-1488. PMID 7849007 DOI: 10.1021/bi00005a003  1
1995 Christiansen WT, Jalbert LR, Robertson RM, Jhingan A, Prorok M, Castellino FJ. Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid Vesicles. Biochemistry. 34: 10376-82. PMID 7654691 DOI: 10.1021/bi00033a008  1
1994 Christiansen WT, Tulinsky A, Castellino FJ. Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein c. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium. Biochemistry. 33: 14993-5000. PMID 7999756 DOI: 10.1021/bi00254a007  1
1993 Mhashilkar AM, Viswanatha T, Chibber BAK, Castellino FJ. Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: Localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin Proceedings of the National Academy of Sciences of the United States of America. 90: 5374-5377. PMID 8506386 DOI: 10.1073/pnas.90.11.5374  1
1993 Menhart N, McCance SG, Sehl LC, Castellino FJ. Functional independence of the kringle 4 and kringle 5 regions of human plasminogen Biochemistry. 32: 8799-8806. PMID 8395882 DOI: 10.1021/bi00085a010  1
1993 Sharma SK, Songster MF, Colpitts TL, Hegyes P, Barany G, Castellino FJ. Reductive amination with tritylamine as an ammonia equivalent: Efficient preparation of the 5-[4-[[(9-fluorenylmethyloxycarbonyl)-amino]methyl]-3,5-dimethoxyphenoxy]valeric acid (PAL) handle for peptide synthesis Journal of Organic Chemistry. 58: 4993-4995.  1
1992 DeSerrano VS, Menhart N, Castellino FJ. Expression, purification, and characterization of the recombinant kringle 1 domain from tissue-type plasminogen activator Archives of Biochemistry and Biophysics. 294: 282-290. PMID 1550352 DOI: 10.1016/0003-9861(92)90170-2  1
1991 Davidson DJ, Bretthauer RK, Castellino FJ. alpha-Mannosidase-catalyzed trimming of high-mannose glycans in noninfected and baculovirus-infected Spodoptera frugiperda cells (IPLB-SF-21AE). A possible contributing regulatory mechanism for assembly of complex-type oligosaccharides in infected cells. Biochemistry. 30: 9811-5. PMID 1911772 DOI: 10.1021/bi00105a001  0.44
1991 Hink WF, Thomsen DR, Davidson DJ, Meyer AL, Castellino FJ. Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines. Biotechnology Progress. 7: 9-14. PMID 1367489 DOI: 10.1021/bp00007a002  1
1991 Wu DW, Duman JG, Cheng CHC, Castellino FJ. Purification and characterization of antifreeze proteins from larvae of the beetle Dendroides canadensis Journal of Comparative Physiology B. 161: 271-278. DOI: 10.1007/BF00262308  1
1989 Whitefleet-Smith J, Rosen E, McLinden J, Ploplis VA, Fraser MJ, Tomlinson JE, McLean JW, Castellino FJ. Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system. Archives of Biochemistry and Biophysics. 271: 390-9. PMID 2658810 DOI: 10.1016/0003-9861(89)90288-9  1
1989 Neven LG, Duman JG, Low MG, Sehl LC, Castellino FJ. Purification and characterization of an insect hemolymph lipoprotein ice nucleator: evidence for the importance of phosphatidylinositol and apolipoprotein in the ice nucleator activity Journal of Comparative Physiology B. 159: 71-82. DOI: 10.1007/BF00692685  1
1988 Beals JM, Weber J, Derwent P, Grant KL, Castellino FJ. Prediction of the secondary structures of bovine blood coagulation factor IX, factor X, and prothrombin Journal of Protein Chemistry. 7: 613-632. PMID 3255381 DOI: 10.1007/BF01024878  1
1988 Hill KA, Steiner SA, Castellino FJ. Estimation of the distance between the divalent cation binding site of des-1-41-light chain-activated bovine plasma protein C and a nitroxide spin label attached to the active-site serine residue. The Biochemical Journal. 251: 229-36. PMID 2839161 DOI: 10.1042/bj2510229  1
1986 Neven LG, Duman JG, Beals JM, Castellino FJ. Overwintering adaptations of the stag beetle, Ceruchus piceus: removal of ice nucleators in the winter to promote supercooling Journal of Comparative Physiology B. 156: 707-716. DOI: 10.1007/BF00692749  1
1985 Duman JG, Neven LG, Beals JM, Olson KR, Castellino FJ. Freeze-tolerance adaptations, including haemolymph protein and lipoprotein nucleators, in the larvae of the cranefly Tipula trivittata Journal of Insect Physiology. 31: 1-5,7-8. DOI: 10.1016/0022-1910(85)90034-4  1
1984 Cummings HS, Pizzo SV, Strickland DK, Castellino FJ. Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis. Biophysical Journal. 45: 721-4. PMID 6202335 DOI: 10.1016/S0006-3495(84)84214-9  0.44
1984 Cummings HS, Ploplis VA, Beals JM, Castellino FJ. Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen. Archives of Biochemistry and Biophysics. 230: 306-15. PMID 6201139 DOI: 10.1016/0003-9861(84)90112-7  1
1984 Duman JG, Morris JP, Castellino FJ. Purification and composition of an ice nucleating protein from queens of the hornet, Vespula maculata Journal of Comparative Physiology B. 154: 79-83. DOI: 10.1007/BF00683219  1
1983 Strickland DK, de Serrano VS, Chan SY, Pollard M, Castellino FJ. Purification and properties of a plasminogen activator from cultured rat prostate adenocarcinoma cells. Biochemistry. 22: 4444-9. PMID 6684952 DOI: 10.1021/bi00288a015  0.48
1983 Castellino FJ, Strickland DK, Morris JP, Smith J, Chibber B. Enhancement of the streptokinase-induced activation of human plasminogen by human fibrinogen and human fibrinogen fragment D1. Annals of the New York Academy of Sciences. 408: 595-601. PMID 6575703 DOI: 10.1111/j.1749-6632.1983.tb23276.x  0.48
1982 Strickland DK, Morris JP, Castellino FJ. Enhancement of the streptokinase-catalyzed activation of human plasminogen by human fibrinogen and its plasminolysis products. Biochemistry. 21: 721-8. PMID 7200372 DOI: 10.1021/bi00533a021  0.48
1982 Ploplis VA, Cummings HS, Castellino FJ. Monoclonal antibodies to discrete regions of human Glu1-plasminogen. Biochemistry. 21: 5891-7. PMID 6185142 DOI: 10.1021/bi00266a025  1
1981 Ploplis VA, Strickland DK, Castellino FJ. Calorimetric evaluation of the existence of separate domains in bovine prothrombin. Biochemistry. 20: 15-21. PMID 7470466 DOI: 10.1021/bi00504a003  1
1981 Strickland DK, Andersen TT, Hill RL, Castellino FJ. Calorimetric study of the rabbit hepatic galactoside binding protein: effects of calcium and ligands. Biochemistry. 20: 5294-7. PMID 7295681  1
1981 Powell JR, Bretthauer RK, Castellino FJ. Effect of tunicamycin on appearance of carbohydrate variants of plasminogen in rat and rabbit plasma. Proceedings of the National Academy of Sciences of the United States of America. 78: 6836-9. PMID 6947257 DOI: 10.1073/pnas.78.11.6836  1
1981 Morris JP, Blatt S, Powell JR, Strickland DK, Castellino FJ. Role of lysine binding regions in the kinetic properties of human plasmin. Biochemistry. 20: 4811-6. PMID 6457628 DOI: 10.1021/bi00520a001  0.48
1980 Morris DA, McNeil R, Castellino FJ, Thomas JK. Interaction of lysophosphatidylcholine with phosphatidylcholine bilayers. A photo-physical and NMR study. Biochimica Et Biophysica Acta. 599: 380-90. PMID 6893279 DOI: 10.1016/0005-2736(80)90185-6  1
1979 Ploplis VA, Thomas JK, Castellino FJ. Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein. Chemistry and Physics of Lipids. 23: 49-62. PMID 221125 DOI: 10.1016/0009-3084(79)90022-7  1
1979 Prieels JP, Bell JE, Schindler M, Castellino FJ, Hill RL. Involvement of histidine-32 in the biological activity of alpha-lactalbumin. Biochemistry. 18: 1771-6. PMID 107966  1
1977 Castellino FJ, Thomas JK, Ploplis VA. Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein. Biochemical and Biophysical Research Communications. 75: 857-62. PMID 193504 DOI: 10.1016/0006-291X(77)91461-9  1
1976 Barlow GH, Finley R, Castellino FJ. Immunological comparison of native streptokinase with streptokinase fragments. Thrombosis Research. 8: 237-42. PMID 814651 DOI: 10.1016/0049-3848(76)90266-8  1
1976 Sodetz JM, Violand BN, Castellino FJ. A kinetic characterization of the rabbit plasmin isozymes Archives of Biochemistry and Biophysics. 174: 209-215. PMID 132894 DOI: 10.1016/0003-9861(76)90340-4  1
1976 Castellino FJ, Sodetz JM. [23] Rabbit plasminogen and plasmin isozymes Methods in Enzymology. 45: 273-286. DOI: 10.1016/S0076-6879(76)45026-7  1
1975 Bell JE, Castellino FJ, Trayer IP, Hill RL. Modification of bovine alpha-lactalbumin with N-bromosuccinimide and 2-hydroxy-5-nitrobenzylbromide. The Journal of Biological Chemistry. 250: 7579-85. PMID 809437  1
1975 Castellino FJ, Schick LA, Brockway WJ, Sodetz JM. The activation and inhibition of fibrinolysis Advances in Experimental Medicine and Biology. 63: 233-243. PMID 128278 DOI: 10.1007/978-1-4684-3258-9_15  1
1975 Violand BN, Sodetz JM, Castellino FJ. The effect of ε{lunate}-amino caproic acid on the gross conformation of plasminogen and plasmin Archives of Biochemistry and Biophysics. 170: 300-305. PMID 126043 DOI: 10.1016/0003-9861(75)90121-6  1
1975 Hayes ML, Bretthauer RK, Castellino FJ. Carbohydrate compositions of the rabbit plasminogen isozymes. Archives of Biochemistry and Biophysics. 171: 651-5. PMID 967 DOI: 10.1016/0003-9861(75)90076-4  1
1974 Schick LA, Castellino FJ. Direct evidence for the generation of an active site in the plasminogen moiety of the streptokinase-human plasminogen activator complex Biochemical and Biophysical Research Communications. 57: 47-54. PMID 4828190 DOI: 10.1016/S0006-291X(74)80355-4  1
1974 Sodetz JM, Brockway WJ, Mann KG, Castellino FJ. The mechanism of activation of rabbit plasminogen by urokinase. Lack of a preactivation peptide Biochemical and Biophysical Research Communications. 60: 729-736. PMID 4278813 DOI: 10.1016/0006-291X(74)90301-5  1
1973 Castellino FJ, Siefring GE, Sodetz JM, Bretthauer RK. Amino terminal amino acid sequences and carbohydrate of the two major forms of rabbit plasminogen. Biochemical and Biophysical Research Communications. 53: 845-51. PMID 4738717 DOI: 10.1016/0006-291X(73)90170-8  1
1973 Castellino FJ, Brockway WJ, Thomas JK, Liano HT, Rawitch AB. Rotational diffusion analysis of the conformational alterations produced in plasminogen by certain antifibrinolytic amino acids. Biochemistry. 12: 2787-91. PMID 4737010 DOI: 10.1021/bi00739a002  0.36
1973 Schick LA, Castellino FJ. Interaction of streptokinase and rabbit plasminogen Biochemistry. 12: 4315-4321. PMID 4270765 DOI: 10.1021/bi00746a003  1
1972 Waterson RM, Castellino FJ, Hass GM, Hill RL. Purification and characterization of crotonase from Clostridium acetobutylicum. The Journal of Biological Chemistry. 247: 5266-71. PMID 5057466  1
1972 Dooley KH, Castellino FJ. Solubility of amino acids in aqueous guanidinium thiocyanate solutions Biochemistry. 11: 1870-1874. PMID 5025628 DOI: 10.1021/bi00760a022  1
1970 Brew K, Castellino FJ, Vanaman TC, Hill RL. The complete amino acid sequence of bovine alpha-lactalbumin. The Journal of Biological Chemistry. 245: 4570-82. PMID 5532231  1
1970 Castellino FJ, Hill RL. The carboxymethylation of bovine alpha-lactalbumin. The Journal of Biological Chemistry. 245: 417-24. PMID 5460891  1
1969 Castellino FJ, Barker R. The effect of guanidinium, carbamoylguanidinium, and guanylguanidinium salts on the solubility of benzoyl-L-tyrosine ethyl ester and acetyltetraglycine ethyl ester in water. Biochemistry. 8: 3439-42. PMID 5809234  1
1968 Castellino FJ, Barker R. The denaturing effectiveness of guanidinium, carbamoylguanidinium, and guanylguanidinium salts. Biochemistry. 7: 4135-8. PMID 5749177  1
1968 Castellino FJ, Barker R. Examination of the dissociation of multichain proteins in guanidine hydrochloride by membrane osmometry. Biochemistry. 7: 2207-17. PMID 5690713  1
1966 Castellino FJ, Barker R. The binding-sites of rabbit muscle aldolase. Biochemical and Biophysical Research Communications. 23: 182-7. PMID 5928910  1
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