| Year |
Citation |
Score |
| 2021 |
Prakash TP, Yu J, Shen W, De Hoyos CL, Berdeja A, Gaus H, Liang XH, Crooke ST, Seth PP. Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides. Acs Medicinal Chemistry Letters. 12: 922-927. PMID 34141070 DOI: 10.1021/acsmedchemlett.1c00072 |
0.32 |
|
| 2021 |
Vasquez G, Freestone GC, Wan WB, Low A, De Hoyos CL, Yu J, Prakash TP, Ǿstergaard ME, Liang XH, Crooke ST, Swayze EE, Migawa MT, Seth PP. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Research. PMID 33544849 DOI: 10.1093/nar/gkab047 |
0.355 |
|
| 2020 |
Shen X, Wong J, Prakash TP, Rigo F, Li Y, Napierala M, Corey DR. Progress towards drug discovery for Friedreich's Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein. Bioorganic & Medicinal Chemistry. 115472. PMID 32279920 DOI: 10.1016/J.Bmc.2020.115472 |
0.385 |
|
| 2019 |
Hu J, Shen X, Rigo F, Prakash TP, Mootha VV, Corey DR. Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy. Nucleic Acid Therapeutics. PMID 30676271 DOI: 10.1089/Nat.2018.0764 |
0.376 |
|
| 2018 |
Prakash TP, Yu J, Kinberger GA, Low A, Jackson M, Rigo F, Swayze EE, Seth PP. Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice. Bioorganic & Medicinal Chemistry Letters. PMID 30342955 DOI: 10.1016/J.Bmcl.2018.10.011 |
0.352 |
|
| 2018 |
McMahon MA, Prakash TP, Cleveland DW, Bennett CF, Rahdar M. Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29650467 DOI: 10.1016/J.Ymthe.2018.02.031 |
0.378 |
|
| 2016 |
Hu J, Rigo F, Prakash TP, Corey DR. Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs. Nucleic Acid Therapeutics. PMID 28005462 DOI: 10.1089/nat.2016.0655 |
0.408 |
|
| 2016 |
Pallan PS, Prakash TP, De Leon AR, Egli M. Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'F-RNA:DNA Hybrid. Biochemistry. PMID 27611889 DOI: 10.1021/Acs.Biochem.6B00849 |
0.679 |
|
| 2016 |
Schirle NT, Kinberger GA, Murray HF, Lima WF, Prakash TP, MacRae IJ. Structural analysis of human Argonaute-2 bound to a modified siRNA guide. Journal of the American Chemical Society. PMID 27380263 DOI: 10.1021/Jacs.6B04454 |
0.386 |
|
| 2015 |
Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26589814 DOI: 10.1073/Pnas.1520883112 |
0.374 |
|
| 2015 |
Burel SA, Hart CE, Cauntay P, Hsiao J, Machemer T, Katz M, Watt A, Bui HH, Younis H, Sabripour M, Freier SM, Hung G, Dan A, Prakash TP, Seth PP, et al. Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts. Nucleic Acids Research. PMID 26553810 DOI: 10.1093/nar/gkv1210 |
0.339 |
|
| 2015 |
Liu J, Hu J, Hicks JA, Prakash TP, Corey DR. Modulation of Splicing by Single-Stranded Silencing RNAs. Nucleic Acid Therapeutics. 25: 113-20. PMID 25757055 DOI: 10.1089/Nat.2014.0527 |
0.371 |
|
| 2014 |
Hu J, Liu J, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Swayze EE, Lima WF, Prakash TP, Xiang Q, Martinez C, Corey DR. Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry. 53: 4510-8. PMID 24981774 DOI: 10.1021/Bi500610R |
0.593 |
|
| 2014 |
Yu J, Pandey SK, Khatri H, Prakash TP, Swayze EE, Seth PP. Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides. Chemmedchem. 9: 2040-4. PMID 24891270 DOI: 10.1002/Cmdc.201402099 |
0.418 |
|
| 2014 |
Hu J, Liu J, Yu D, Aiba Y, Lee S, Pendergraff H, Boubaker J, Artates JW, Lagier-Tourenne C, Lima WF, Swayze EE, Prakash TP, Corey DR. Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs. Nucleic Acid Therapeutics. 24: 199-209. PMID 24694346 DOI: 10.1089/Nat.2013.0476 |
0.353 |
|
| 2013 |
Migawa MT, Prakash TP, Vasquez G, Seth PP, Swayze EE. Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA). Organic Letters. 15: 4316-9. PMID 23937264 DOI: 10.1021/ol401730d |
0.482 |
|
| 2013 |
Liu J, Yu D, Aiba Y, Pendergraff H, Swayze EE, Lima WF, Hu J, Prakash TP, Corey DR. ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy. Nucleic Acids Research. 41: 9570-83. PMID 23935115 DOI: 10.1093/Nar/Gkt693 |
0.341 |
|
| 2013 |
Matsui M, Prakash TP, Corey DR. Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter. Acs Chemical Biology. 8: 122-6. PMID 23082936 DOI: 10.1021/Cb300490J |
0.402 |
|
| 2012 |
Yu D, Pendergraff H, Liu J, Kordasiewicz HB, Cleveland DW, Swayze EE, Lima WF, Crooke ST, Prakash TP, Corey DR. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell. 150: 895-908. PMID 22939619 DOI: 10.1016/J.Cell.2012.08.002 |
0.359 |
|
| 2012 |
Lima WF, Prakash TP, Murray HM, Kinberger GA, Li W, Chappell AE, Li CS, Murray SF, Gaus H, Seth PP, Swayze EE, Crooke ST. Single-stranded siRNAs activate RNAi in animals. Cell. 150: 883-94. PMID 22939618 DOI: 10.1016/j.cell.2012.08.014 |
0.382 |
|
| 2012 |
Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M. Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs. Chemical Communications (Cambridge, England). 48: 8195-7. PMID 22614180 DOI: 10.1039/C2Cc32286B |
0.665 |
|
| 2012 |
Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nature Chemical Biology. 8: 555-61. PMID 22504300 DOI: 10.1038/Nchembio.939 |
0.381 |
|
| 2011 |
Prakash TP. An overview of sugar-modified oligonucleotides for antisense therapeutics. Chemistry & Biodiversity. 8: 1616-41. PMID 21922654 DOI: 10.1002/cbdv.201100081 |
0.334 |
|
| 2011 |
Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP. Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides. Journal of the American Chemical Society. 133: 16642-9. PMID 21919455 DOI: 10.1021/Ja207086X |
0.672 |
|
| 2011 |
Seth PP, Prakash TP. Synthesis of 2',4'-bridged nucleosides using a new orthogonally protected sugar synthon: 5-O-(tert-butyldiphenylsilyl)-4-C-hydroxymethyl-1,2-O-isopropylidene-3-O-napthyl-α-D-allofuranose. Current Protocols in Nucleic Acid Chemistry. Unit 1.24. PMID 21400702 DOI: 10.1002/0471142700.nc0124s44 |
0.309 |
|
| 2010 |
Seth PP, Allerson CR, Berdeja A, Siwkowski A, Pallan PS, Gaus H, Prakash TP, Watt AT, Egli M, Swayze EE. An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA. Journal of the American Chemical Society. 132: 14942-50. PMID 20886816 DOI: 10.1021/Ja105875E |
0.647 |
|
| 2010 |
Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. The Journal of Organic Chemistry. 75: 1569-81. PMID 20136157 DOI: 10.1021/Jo902560F |
0.352 |
|
| 2009 |
Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution. Chemical Communications (Cambridge, England). 2017-9. PMID 19333476 DOI: 10.1039/B822781K |
0.681 |
|
| 2009 |
Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals. Journal of Medicinal Chemistry. 52: 10-3. PMID 19086780 DOI: 10.1021/jm801294h |
0.314 |
|
| 2009 |
Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST. Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids. The Journal of Biological Chemistry. 284: 2535-48. PMID 19017633 DOI: 10.1074/jbc.M803748200 |
0.399 |
|
| 2007 |
Prakash TP, Bhat B. 2'-Modified oligonucleotides for antisense therapeutics. Current Topics in Medicinal Chemistry. 7: 641-9. PMID 17430205 |
0.391 |
|
| 2006 |
Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash TP, Allerson CR, Swayze EE, Marcusson EG, Dean NM. Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Research. 34: 4467-76. PMID 16945958 DOI: 10.1093/nar/gkl589 |
0.353 |
|
| 2006 |
Prakash TP, Kraynack B, Baker BF, Swayze EE, Bhat B. RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells. Bioorganic & Medicinal Chemistry Letters. 16: 3238-40. PMID 16616491 DOI: 10.1016/J.Bmcl.2006.03.053 |
0.429 |
|
| 2006 |
Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. Biochemistry. 45: 4141-52. PMID 16566588 DOI: 10.1021/Bi052322R |
0.492 |
|
| 2006 |
Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B. Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. Journal of Medicinal Chemistry. 49: 1624-34. PMID 16509579 DOI: 10.1021/jm050822c |
0.45 |
|
| 2005 |
Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines. Nucleic Acids Research. 33: 5297-307. PMID 16170156 DOI: 10.1093/Nar/Gki823 |
0.733 |
|
| 2005 |
Prakash TP, Allerson CR, Dande P, Vickers TA, Sioufi N, Jarres R, Baker BF, Swayze EE, Griffey RH, Bhat B. Positional effect of chemical modifications on short interference RNA activity in mammalian cells. Journal of Medicinal Chemistry. 48: 4247-53. PMID 15974578 DOI: 10.1021/jm050044o |
0.437 |
|
| 2005 |
Egli M, Minasov G, Tereshko V, Pallan PS, Teplova M, Inamati GB, Lesnik EA, Owens SR, Ross BS, Prakash TP, Manoharan M. Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications. Biochemistry. 44: 9045-57. PMID 15966728 DOI: 10.1021/Bi050574M |
0.712 |
|
| 2005 |
Prakash TP, Prhavc M, Eldrup AB, Cook PD, Carroll SS, Olsen DB, Stahlhut MW, Tomassini JE, MacCoss M, Galloway SM, Hilliard C, Bhat B. Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication. Journal of Medicinal Chemistry. 48: 1199-210. PMID 15715486 DOI: 10.1021/jm0495172 |
0.31 |
|
| 2005 |
Allerson CR, Sioufi N, Jarres R, Prakash TP, Naik N, Berdeja A, Wanders L, Griffey RH, Swayze EE, Bhat B. Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. Journal of Medicinal Chemistry. 48: 901-4. PMID 15715458 DOI: 10.1021/jm049167j |
0.46 |
|
| 2004 |
Pattanayek R, Sethaphong L, Pan C, Prhavc M, Prakash TP, Manoharan M, Egli M. Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues. Journal of the American Chemical Society. 126: 15006-7. PMID 15547979 DOI: 10.1021/Ja044637K |
0.525 |
|
| 2004 |
Lima WF, Nichols JG, Wu H, Prakash TP, Migawa MT, Wyrzykiewicz TK, Bhat B, Crooke ST. Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis. The Journal of Biological Chemistry. 279: 36317-26. PMID 15205459 DOI: 10.1074/jbc.M405035200 |
0.446 |
|
| 2004 |
Prakash TP, Püschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M. 2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures. Organic Letters. 6: 1971-4. PMID 15176796 DOI: 10.1021/Ol049470E |
0.499 |
|
| 2004 |
Eldrup AB, Allerson CR, Bennett CF, Bera S, Bhat B, Bhat N, Bosserman MR, Brooks J, Burlein C, Carroll SS, Cook PD, Getty KL, MacCoss M, McMasters DR, Olsen DB, ... Prakash TP, et al. Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. Journal of Medicinal Chemistry. 47: 2283-95. PMID 15084127 DOI: 10.1021/jm030424e |
0.324 |
|
| 2004 |
Prakash TP, Johnston JF, Graham MJ, Condon TP, Manoharan M. 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo. Nucleic Acids Research. 32: 828-33. PMID 14762210 DOI: 10.1093/nar/gkh220 |
0.304 |
|
| 2003 |
Lima WF, Wu H, Nichols JG, Prakash TP, Ravikumar V, Crooke ST. Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate. The Journal of Biological Chemistry. 278: 49860-7. PMID 14506260 DOI: 10.1074/jbc.M306543200 |
0.426 |
|
| 2003 |
Rajeev KG, Prakash TP, Manoharan M. 2'-modified-2-thiothymidine oligonucleotides. Organic Letters. 5: 3005-8. PMID 12916967 DOI: 10.1021/ol0348607 |
0.65 |
|
| 2003 |
Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M. 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects. Organic Letters. 5: 2017-20. PMID 12790517 DOI: 10.1021/Ol0340991 |
0.381 |
|
| 2002 |
Prakash TP, Manoharan M, Kawasaki AM, Fraser AS, Lesnik EA, Sioufi N, Leeds JM, Teplova M, Egli M. 2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA. Biochemistry. 41: 11642-8. PMID 12269806 DOI: 10.1021/Bi020264T |
0.4 |
|
| 2002 |
Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M. Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides. The Journal of Organic Chemistry. 67: 357-69. PMID 11798305 |
0.375 |
|
| 2000 |
Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. 2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides. Organic Letters. 2: 3995-8. PMID 11112626 |
0.327 |
|
| 1996 |
Strauss JK, Prakash TP, Roberts C, Switzer C, Maher LJ. DNA bending by a phantom protein Chemistry and Biology. 3: 571-678. PMID 8807901 DOI: 10.1016/S1074-5521(96)90135-0 |
0.31 |
|
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