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K. G. Rajeev - Publications

Affiliations: 
1997 CSIR-National Chemical Laboratory, Pune, India 
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, et al. 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates. Chembiochem : a European Journal of Chemical Biology. PMID 27121751 DOI: 10.1002/cbic.201600130  0.64
2016 Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, et al. Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-10. PMID 27033334 DOI: 10.3109/13506129.2016.1160882  0.64
2016 Kel In AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M. Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. The Journal of Organic Chemistry. PMID 26940174 DOI: 10.1021/acs.joc.5b02375  0.64
2015 Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. 5'-C-Malonyl RNA: small interfering RNAs modified with 5'-monophosphate bioisostere demonstrate gene silencing activity. Acs Chemical Biology. PMID 26675211 DOI: 10.1021/acschembio.5b00654  0.64
2015 Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, ... ... Rajeev KG, et al. An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nature Medicine. 21: 492-7. PMID 25849132 DOI: 10.1038/nm.3847  0.64
2015 Rajeev KG, Nair JK, Jayaraman M, Charisse K, Taneja N, O'Shea J, Willoughby JL, Yucius K, Nguyen T, Shulga-Morskaya S, Milstein S, Liebow A, Querbes W, Borodovsky A, Fitzgerald K, et al. Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo. Chembiochem : a European Journal of Chemical Biology. 16: 903-8. PMID 25786782 DOI: 10.1002/cbic.201500023  0.64
2015 Matsuda S, Keiser K, Nair JK, Charisse K, Manoharan RM, Kretschmer P, Peng CG, V Kel'in A, Kandasamy P, Willoughby JL, Liebow A, Querbes W, Yucius K, Nguyen T, Milstein S, ... ... Rajeev KG, et al. siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes. Acs Chemical Biology. 10: 1181-7. PMID 25730476 DOI: 10.1021/cb501028c  0.64
2014 Nair JK, Willoughby JL, Chan A, Charisse K, Alam MR, Wang Q, Hoekstra M, Kandasamy P, Kel'in AV, Milstein S, Taneja N, O'Shea J, Shaikh S, Zhang L, van der Sluis RJ, ... ... Rajeev KG, et al. Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society. 136: 16958-61. PMID 25434769 DOI: 10.1021/ja505986a  0.64
2014 Hu J, Liu J, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Swayze EE, Lima WF, Prakash TP, Xiang Q, Martinez C, Corey DR. Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry. 53: 4510-8. PMID 24981774 DOI: 10.1021/bi500610r  0.64
2013 Liu J, Pendergraff H, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Hu J, Corey DR. RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Research. 41: 8788-801. PMID 23887934 DOI: 10.1093/nar/gkt594  0.64
2013 Maier MA, Jayaraman M, Matsuda S, Liu J, Barros S, Querbes W, Tam YK, Ansell SM, Kumar V, Qin J, Zhang X, Wang Q, Panesar S, Hutabarat R, Carioto M, ... ... Rajeev KG, et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1570-8. PMID 23799535 DOI: 10.1038/mt.2013.124  0.64
2013 Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M. Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA. Bioorganic & Medicinal Chemistry. 21: 722-32. PMID 23260577 DOI: 10.1016/j.bmc.2012.11.043  0.64
2012 Shenoi RA, Narayanannair JK, Hamilton JL, Lai BF, Horte S, Kainthan RK, Varghese JP, Rajeev KG, Manoharan M, Kizhakkedathu JN. Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells. Journal of the American Chemical Society. 134: 14945-57. PMID 22906064 DOI: 10.1021/ja305080f  0.64
2012 Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, ... ... Rajeev KG, et al. Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1582-9. PMID 22850721 DOI: 10.1038/mt.2012.33  0.64
2012 Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Angewandte Chemie - International Edition. 51: 8529-8533. PMID 22782619 DOI: 10.1002/anie.201203263  0.64
2011 Manoharan M, Akinc A, Pandey RK, Qin J, Hadwiger P, John M, Mills K, Charisse K, Maier MA, Nechev L, Greene EM, Pallan PS, Rozners E, Rajeev KG, Egli M. Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs. Angewandte Chemie (International Ed. in English). 50: 2284-8. PMID 21351337 DOI: 10.1002/anie.201006519  0.64
2011 Yamada T, Peng CG, Matsuda S, Addepalli H, Jayaprakash KN, Alam MR, Mills K, Maier MA, Charisse K, Sekine M, Manoharan M, Rajeev KG. Versatile site-specific conjugation of small molecules to siRNA using click chemistry. The Journal of Organic Chemistry. 76: 1198-211. PMID 21299239 DOI: 10.1021/jo101761g  0.64
2010 Jayaprakash KN, Peng CG, Butler D, Varghese JP, Maier MA, Rajeev KG, Manoharan M. Non-nucleoside building blocks for copper-assisted and copper-free click chemistry for the efficient synthesis of RNA conjugates. Organic Letters. 12: 5410-3. PMID 21049912 DOI: 10.1021/ol102205j  0.64
2010 Addepalli H, Meena, Peng CG, Wang G, Fan Y, Charisse K, Jayaprakash KN, Rajeev KG, Pandey RK, Lavine G, Zhang L, Jahn-Hofmann K, Hadwiger P, Manoharan M, Maier MA. Modulation of thermal stability can enhance the potency of siRNA. Nucleic Acids Research. 38: 7320-31. PMID 20610434 DOI: 10.1093/nar/gkq568  0.64
2010 Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, Butler JS, Qin L, Racie T, Sprague A, Fava E, et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1357-64. PMID 20461061 DOI: 10.1038/mt.2010.85  0.64
2010 Chen Q, Butler D, Querbes W, Pandey RK, Ge P, Maier MA, Zhang L, Rajeev KG, Nechev L, Kotelianski V, Manoharan M, Sah DW. Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 144: 227-32. PMID 20170694 DOI: 10.1016/j.jconrel.2010.02.011  0.64
2010 Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, et al. Rational design of cationic lipids for siRNA delivery. Nature Biotechnology. 28: 172-6. PMID 20081866 DOI: 10.1038/nbt.1602  0.64
2009 Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 872-9. PMID 19259063 DOI: 10.1038/mt.2009.36  0.64
2008 Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, Gamba-Vitalo C, Hadwiger P, Jayaraman M, John M, Jayaprakash KN, ... ... Rajeev KG, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 105: 11915-20. PMID 18695239 DOI: 10.1073/pnas.0805434105  0.64
2008 Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, ... ... Rajeev KG, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature Biotechnology. 26: 561-9. PMID 18438401 DOI: 10.1038/nbt1402  0.64
2007 DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proceedings of the National Academy of Sciences of the United States of America. 104: 17204-9. PMID 17940007 DOI: 10.1073/pnas.0708285104  0.64
2007 Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Research. 35: 6424-38. PMID 17881374 DOI: 10.1093/nar/gkm664  0.64
2007 Krützfeldt J, Kuwajima S, Braich R, Rajeev KG, Pena J, Tuschl T, Manoharan M, Stoffel M. Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Research. 35: 2885-92. PMID 17439965 DOI: 10.1093/nar/gkm024  0.64
2005 Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of microRNAs in vivo with 'antagomirs' Nature. 438: 685-689. PMID 16258535 DOI: 10.1038/nature04303  0.64
2005 Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines. Nucleic Acids Research. 33: 5297-307. PMID 16170156 DOI: 10.1093/nar/gki823  0.64
1997 Rajeev KG, Jadhav VR, Ganesh KN. Triplex formation at physiological pH: comparative studies on DNA triplexes containing 5-Me-dC tethered at N4 with spermine and tetraethyleneoxyamine. Nucleic Acids Research. 25: 4187-93. PMID 9336445 DOI: 10.1093/nar/25.21.4187  0.64
1996 Barawkar DA, Rajeev KG, Kumar VA, Ganesh KN. Triplex formation at physiological pH by 5-Me-dC-N4-(spermine) [X] oligodeoxynucleotides: non protonation of N3 in X of X*G:C triad and effect of base mismatch/ionic strength on triplex stabilities. Nucleic Acids Research. 24: 1229-37. PMID 8614624  0.68
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