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Vasant Jadhav - Publications

Affiliations: 
1998 CSIR-National Chemical Laboratory, Pune, India 
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Jadhav V, Vaishnaw A, Fitzgerald K, Maier MA. RNA interference in the era of nucleic acid therapeutics. Nature Biotechnology. 42: 394-405. PMID 38409587 DOI: 10.1038/s41587-023-02105-y  0.397
2023 Subramanian M, McIninch J, Zlatev I, Schlegel MK, Kaittanis C, Nguyen T, Agarwal S, Racie T, Alvarado MA, Wassarman K, Collins TS, Chickering T, Brown CR, Schmidt K, Castoreno AB, ... ... Jadhav V, et al. RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes. Nature Communications. 14: 1970. PMID 37031257 DOI: 10.1038/s41467-023-37774-5  0.374
2022 Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, ... ... Jadhav V, et al. From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic Acids Research. PMID 35736224 DOI: 10.1093/nar/gkac539  0.448
2022 Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, ... ... Jadhav V, et al. Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nature Biotechnology. PMID 35654979 DOI: 10.1038/s41587-022-01334-x  0.373
2021 Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, et al. Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Nucleic Acids Research. PMID 34508350 DOI: 10.1093/nar/gkab724  0.488
2021 Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Zarazowski JM, Jadhav V, Maier MA, Sepp-Lorenzino L, et al. Centyrin Ligands for Extrahepatic Delivery of siRNA. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33601052 DOI: 10.1016/j.ymthe.2021.02.015  0.314
2020 Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, ... ... Jadhav V, et al. Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 32808038 DOI: 10.1093/Nar/Gkaa670  0.453
2019 Kumar P, Parmar RG, Brown CR, Willoughby JLS, Foster DJ, Babu IR, Schofield S, Jadhav V, Charisse K, Nair JK, Rajeev KG, Maier MA, Egli M, Manoharan M. 5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger. Chemical Communications (Cambridge, England). PMID 30977478 DOI: 10.1039/C9Cc00977A  0.667
2019 Janas MM, Zlatev I, Liu J, Jiang Y, Barros SA, Sutherland JE, Davis WP, Liu J, Brown CR, Liu X, Schlegel MK, Blair L, Zhang X, Das B, Tran C, ... ... Jadhav V, et al. Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 30820542 DOI: 10.1093/Nar/Gkz140  0.631
2018 Zewge D, Butora G, Sherer EC, Tellers DM, Sidler DR, Gouker J, Copeland G, Jadhav V, Li Z, Armstrong J, Davies IW. Post-Synthetic Modification of Oligonucleotides via Orthogonal Amidation and Copper Catalyzed Cycloaddition Reactions. Bioconjugate Chemistry. PMID 29893553 DOI: 10.1021/Acs.Bioconjchem.8B00298  0.316
2018 Zlatev I, Castoreno A, Brown CR, Qin J, Waldron S, Schlegel MK, Degaonkar R, Shulga-Morskaya S, Xu H, Gupta S, Matsuda S, Akinc A, Rajeev KG, Manoharan M, Maier MA, ... Jadhav V, et al. Reversal of siRNA-mediated gene silencing in vivo. Nature Biotechnology. PMID 29786096 DOI: 10.1038/Nbt.4136  0.686
2018 Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V. Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity. Nature Communications. 9: 723. PMID 29459660 DOI: 10.1038/S41467-018-02989-4  0.662
2018 Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29456020 DOI: 10.1016/J.Ymthe.2017.12.021  0.685
2018 Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG. Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates. Journal of Medicinal Chemistry. PMID 29376650 DOI: 10.1021/Acs.Jmedchem.7B01147  0.67
2017 Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, ... Jadhav V, et al. Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28988716 DOI: 10.1016/J.Ymthe.2017.08.019  0.623
2017 Nair JK, Attarwala H, Sehgal A, Wang Q, Aluri K, Zhang X, Gao M, Liu J, Indrakanti R, Schofield S, Kretschmer P, Brown CR, Gupta S, Willoughby JLS, Boshar JA, ... Jadhav V, et al. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates. Nucleic Acids Research. PMID 28981809 DOI: 10.1093/Nar/Gkx818  0.683
2016 Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, ... ... Jadhav V, et al. 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates. Chembiochem : a European Journal of Chemical Biology. PMID 27121751 DOI: 10.1002/Cbic.201600130  0.69
2016 Parmar R, Willoughby JLS, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, ... ... Jadhav V, et al. Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016) Chembiochem. 17: 970-970. DOI: 10.1002/Cbic.201600278  0.637
2015 Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. 5'-C-Malonyl RNA: small interfering RNAs modified with 5'-monophosphate bioisostere demonstrate gene silencing activity. Acs Chemical Biology. PMID 26675211 DOI: 10.1021/Acschembio.5B00654  0.688
2014 Zewge D, Gosselin F, Kenski DM, Li J, Jadhav V, Yuan Y, Nerurkar SS, Tellers DM, Flanagan WM, Davies IW. High-throughput chemical modification of oligonucleotides for systematic structure-activity relationship evaluation. Bioconjugate Chemistry. 25: 2222-32. PMID 25398098 DOI: 10.1021/Bc500453Q  0.393
2014 Janout V, Cline LL, Feuston BP, Klein L, O'Brien A, Tucker T, Yuan Y, O'Neill-Davis LA, Peiffer RL, Nerurkar SS, Jadhav V, Tellers DM, Regen SL. Molecular umbrella conjugate for the ocular delivery of siRNA Bioconjugate Chemistry. 25: 197-201. PMID 24433067 DOI: 10.1021/Bc400506M  0.435
2010 Abrams MT, Koser ML, Seitzer J, Williams SC, DiPietro MA, Wang W, Shaw AW, Mao X, Jadhav V, Davide JP, Burke PA, Sachs AB, Stirdivant SM, Sepp-Lorenzino L. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 171-80. PMID 19738601 DOI: 10.1038/Mt.2009.208  0.37
2005 Morrissey DV, Lockridge JA, Shaw L, Blanchard K, Jensen K, Breen W, Hartsough K, Machemer L, Radka S, Jadhav V, Vaish N, Zinnen S, Vargeese C, Bowman K, Shaffer CS, et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnology. 23: 1002-7. PMID 16041363 DOI: 10.1038/Nbt1122  0.405
2004 Kossen K, Vaish NK, Jadhav VR, Pasko C, Wang H, Jenison R, McSwiggen JA, Polisky B, Seiwert SD. High-throughput ribozyme-based assays for detection of viral nucleic acids. Chemistry & Biology. 11: 807-15. PMID 15217614 DOI: 10.1016/j.chembiol.2004.03.029  0.31
2002 Jadhav VR, Yarus M. Coenzymes as coribozymes. Biochimie. 84: 877-88. PMID 12458080 DOI: 10.1016/S0300-9084(02)01404-9  0.382
2002 Jadhav VR, Yarus M. Acyl-CoAs from coenzyme ribozymes. Biochemistry. 41: 723-9. PMID 11790093 DOI: 10.1021/Bi011803H  0.39
1996 Kaiwar SP, Sreedhara A, Raghavan MS, Rao CP, Jadhav V, Ganesh KN. Synthesis, characterization and DNA interaction studies of CrIII products isolated from CrVI reduction with —SH containing molecules Polyhedron. 15: 765-774. DOI: 10.1016/0277-5387(95)00359-7  0.484
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