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Zena Werb - Publications

Anatomy University of California, San Francisco, San Francisco, CA 
role of the cellular microenvironment and intercellular communication in breast development and cancer

209 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & Development. PMID 29483153 DOI: 10.1101/gad.301366.117  0.48
2018 Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29339479 DOI: 10.1073/pnas.1718009115  0.92
2017 Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28258171 DOI: 10.1073/pnas.1701690114  0.72
2017 Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. Molecular and Clinical Oncology. 6: 7-18. PMID 28123722 DOI: 10.3892/mco.2016.1094  0.72
2016 Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. PMID 27756881 DOI: 10.18632/oncotarget.12658  0.48
2016 Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621461 DOI: 10.1073/pnas.1611532113  1
2016 Chou J, Chan MF, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiology Spectrum. 4. PMID 27227311 DOI: 10.1128/microbiolspec.MCHD-0002-2015  0.92
2016 Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903627 DOI: 10.1073/pnas.1600645113  1
2015 Lawson DA, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harbor Protocols. 2015: pdb.prot078071. PMID 26631119 DOI: 10.1101/pdb.prot078071  1
2015 Kim M, Shewan A, Ewald AJ, Werb Z, Mostov KE. P114RhoGEF governs cell motility and lumen formation during tubulogenesis via ROCK-myosin II pathway. Journal of Cell Science. PMID 26483385 DOI: 10.1242/jcs.172361  1
2015 Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. PMID 26416748 DOI: 10.1038/nature15260  1
2015 Werb Z, Lu P. The Role of Stroma in Tumor Development. Cancer Journal (Sudbury, Mass.). 21: 250-3. PMID 26222075 DOI: 10.1097/PPO.0000000000000127  1
2015 Chan MF, Werb Z. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio-Protocol. 5: e1517. PMID 26191537  0.44
2015 Chan MF, Werb Z. Animal Models of Corneal Injury. Bio-Protocol. 5: e1516. PMID 26191536  0.44
2015 Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 4: e1008871. PMID 26155427 DOI: 10.1080/2162402X.2015.1008871  1
2015 Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nature Cell Biology. 17: 804-15. PMID 26005835 DOI: 10.1038/ncb3175  1
2015 Chambers AF, Werb Z. Invasion and metastasis--recent advances and future challenges. Journal of Molecular Medicine (Berlin, Germany). 93: 361-8. PMID 25772709 DOI: 10.1007/s00109-015-1269-z  1
2015 Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 16: 225-38. PMID 25748930 DOI: 10.1016/j.stem.2015.02.015  1
2015 Kessenbrock K, Wang CY, Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biology : Journal of the International Society For Matrix Biology. 44: 184-190. PMID 25661772 DOI: 10.1016/j.matbio.2015.01.022  1
2015 Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 112: E566-75. PMID 25624500 DOI: 10.1073/pnas.1424927112  1
2015 Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 160: 119-31. PMID 25594177 DOI: 10.1016/j.cell.2014.12.028  1
2015 Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. The Journal of Biological Chemistry. 290: 3803-13. PMID 25538248 DOI: 10.1074/jbc.M114.611202  1
2015 Hagerling C, Casbon AJ, Werb Z. Balancing the innate immune system in tumor development. Trends in Cell Biology. 25: 214-20. PMID 25444276 DOI: 10.1016/j.tcb.2014.11.001  1
2015 Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, vandenBijgaart RJE, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis Developmental Cell. DOI: 10.1016/j.devcel.2015.07.015  1
2015 Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels Biotechnology Reports. 7: 157-165. DOI: 10.1016/j.btre.2015.07.001  1
2014 Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nature Reviews. Molecular Cell Biology. 15: 786-801. PMID 25415508 DOI: 10.1038/nrm3904  1
2014 Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proceedings of the National Academy of Sciences of the United States of America. 111: E5086-95. PMID 25385645 DOI: 10.1073/pnas.1419899111  1
2014 Bonnans C, Lohela M, Werb Z. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. Journal of Visualized Experiments : Jove. e51916. PMID 25350573 DOI: 10.3791/51916  1
2014 Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Developmental Cell. 31: 171-87. PMID 25307480 DOI: 10.1016/j.devcel.2014.08.027  1
2014 Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 2078-92. PMID 25017248 DOI: 10.1158/1055-9965.EPI-14-0403  1
2014 Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. Plos One. 9: e96408. PMID 24788791 DOI: 10.1371/journal.pone.0096408  1
2013 Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 155: 1639-51. PMID 24332913 DOI: 10.1016/j.cell.2013.11.029  1
2013 Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. Plos Biology. 11: e1001712. PMID 24260022 DOI: 10.1371/journal.pbio.1001712  1
2013 Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle (Georgetown, Tex.). 12: 3262-71. PMID 24036551 DOI: 10.4161/cc.26087  1
2013 Plaks V, Koopman CD, Werb Z. Cancer. Circulating tumor cells. Science (New York, N.Y.). 341: 1186-8. PMID 24031008 DOI: 10.1126/science.1235226  1
2013 Brabletz T, Lyden D, Steeg PS, Werb Z. Roadblocks to translational advances on metastasis research. Nature Medicine. 19: 1104-9. PMID 24013756 DOI: 10.1038/nm.3327  1
2013 Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 13: 300-13. PMID 23871604 DOI: 10.1016/j.stem.2013.06.005  1
2013 Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. Journal of Cell Science. 126: 3948-60. PMID 23813962 DOI: 10.1242/jcs.128033  1
2013 Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proceedings of the National Academy of Sciences of the United States of America. 110: 11109-14. PMID 23776237 DOI: 10.1073/pnas.1309561110  1
2013 Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, ... ... Werb Z, et al. Molecular determinants of lung development. Annals of the American Thoracic Society. 10: S12-6. PMID 23607856 DOI: 10.1513/AnnalsATS.201207-036OT  1
2013 Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nature Cell Biology. 15: 201-13. PMID 23354167 DOI: 10.1038/ncb2672  1
2013 Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Reports. 3: 70-8. PMID 23352663 DOI: 10.1016/j.celrep.2012.12.017  1
2013 Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 52: 111-9. PMID 23010105 DOI: 10.1016/j.bone.2012.09.018  1
2012 Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discovery. 2: 1078-80. PMID 23230184 DOI: 10.1158/2159-8290.CD-12-0465  1
2012 Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proceedings of the National Academy of Sciences of the United States of America. 109: E2595-604. PMID 22923691 DOI: 10.1073/pnas.1212834109  1
2012 Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, ... ... Werb Z, et al. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discovery. 2: 638-51. PMID 22728437 DOI: 10.1158/2159-8290.CD-12-0093  1
2012 Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. The Journal of Clinical Investigation. 122: 2661-71. PMID 22684106 DOI: 10.1172/JCI61303  1
2012 Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, et al. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 21: 488-503. PMID 22516258 DOI: 10.1016/j.ccr.2012.02.017  1
2012 Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 21: 402-17. PMID 22439936 DOI: 10.1016/j.ccr.2012.01.008  1
2012 Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. The Journal of Cell Biology. 196: 395-406. PMID 22351925 DOI: 10.1083/jcb.201102147  1
2012 Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. Journal of Cell Science. 125: 2638-54. PMID 22344263 DOI: 10.1242/jcs.096875  1
2012 Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. The Journal of Clinical Investigation. 122: 911-22. PMID 22293178 DOI: 10.1172/JCI58215  1
2012 Ashkenas J, Damsky CH, Bissell MJ, Werb Z. Integrins, Signaling, and the Remodeling of the Extracellular Matrix Integrins: Molecular and Biological Responses to the Extracellular Matrix. 79-109. DOI: 10.1016/B978-0-08-091729-0.50009-7  1
2011 Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15894-903. PMID 22049432 DOI: 10.1523/JNEUROSCI.3943-11.2011  1
2011 Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21917992 DOI: 10.1101/cshperspect.a005058  1
2011 Lin L, Bankaitis E, Heimbach L, Li N, Abrink M, Pejler G, An L, Diaz LA, Werb Z, Liu Z. Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. The Journal of Biological Chemistry. 286: 37358-67. PMID 21880713 DOI: 10.1074/jbc.M111.272401  1
2011 Hong JS, Greenlee KJ, Pitchumani R, Lee SH, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. Journal of Immunology (Baltimore, Md. : 1950). 186: 6427-36. PMID 21508260 DOI: 10.4049/jimmunol.1003449  1
2011 Kessenbrock K, Brown M, Werb Z. Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit14.24. PMID 21462166 DOI: 10.1002/0471142735.im1424s93  1
2011 Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nature Chemical Biology. 7: 206-13. PMID 21390037 DOI: 10.1038/nchembio.534  1
2011 Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes & Development. 25: 471-84. PMID 21317240 DOI: 10.1101/gad.1998111  1
2011 Ewald AJ, Werb Z, Egeblad M. Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harbor Protocols. 2011: pdb.top97. PMID 21285277 DOI: 10.1101/pdb.top97  1
2011 Ewald AJ, Werb Z, Egeblad M. Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harbor Protocols. 2011: pdb.prot5563. PMID 21285263 DOI: 10.1101/pdb.prot5563  1
2011 Ewald AJ, Werb Z, Egeblad M. Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harbor Protocols. 2011: pdb.prot5562. PMID 21285262 DOI: 10.1101/pdb.prot5562  1
2011 Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Disease Models & Mechanisms. 4: 203-11. PMID 21135056 DOI: 10.1242/dmm.006304  1
2011 Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harbor Perspectives in Biology. 3. PMID 21106646 DOI: 10.1101/cshperspect.a004333  1
2011 Werb Z. A sticky wicket: Opposing functions of p120-catenin in development and cancer Developmental Cell. 20: e3. DOI: 10.1016/j.devcel.2011.05.006  1
2010 Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 21795-800. PMID 21098272 DOI: 10.1073/pnas.1016485107  1
2010 Werb Z. The joy of a career in cell biology. Molecular Biology of the Cell. 21: 3764-6. PMID 21079003 DOI: 10.1091/mbc.E10-05-0413  1
2010 Werb Z. The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain. Disease Models & Mechanisms. 3: 513-6. PMID 20699476 DOI: 10.1242/dmm.006338  1
2010 Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Developmental Cell. 18: 884-901. PMID 20627072 DOI: 10.1016/j.devcel.2010.05.012  1
2010 Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 16: 156-70. PMID 20400713 DOI: 10.1177/1073858409355830  1
2010 Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 141: 52-67. PMID 20371345 DOI: 10.1016/j.cell.2010.03.015  1
2010 Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, et al. Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease Models & Mechanisms. 3: 317-32. PMID 20223936 DOI: 10.1242/dmm.003863  1
2010 Littlepage LE, Sternlicht MD, Rougier N, Phillips J, Gallo E, Yu Y, Williams K, Brenot A, Gordon JI, Werb Z. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Research. 70: 2224-34. PMID 20215503 DOI: 10.1158/0008-5472.CAN-09-3515  1
2010 Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Disease Models & Mechanisms. 3: 224-35. PMID 20142327 DOI: 10.1242/dmm.004226  1
2010 Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, ... Werb Z, et al. Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood. 115: 4302-12. PMID 20110420 DOI: 10.1182/blood-2009-08-236851  1
2010 Lohela M, Werb Z. Intravital imaging of stromal cell dynamics in tumors. Current Opinion in Genetics & Development. 20: 72-8. PMID 19942428 DOI: 10.1016/j.gde.2009.10.011  1
2010 Lederle W, Hartenstein B, Meides A, Kunzelmann H, Werb Z, Angel P, Mueller MM. MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis. 31: 1175-84. PMID 19892798 DOI: 10.1093/carcin/bgp248  1
2010 Lilla JN, Werb Z. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Developmental Biology. 337: 124-33. PMID 19850030 DOI: 10.1016/j.ydbio.2009.10.021  1
2010 Chou J, Provot S, Werb Z. GATA3 in development and cancer differentiation: cells GATA have it! Journal of Cellular Physiology. 222: 42-9. PMID 19798694 DOI: 10.1002/jcp.21943  1
2009 Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Mapping mammary gland architecture using multi-scale in situ analysis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 80-9. PMID 20023794 DOI: 10.1039/b816933k  1
2009 Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis and Rheumatism. 60: 3723-33. PMID 19950295 DOI: 10.1002/art.25002  1
2009 Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. The Journal of Clinical Investigation. 119: 3713-22. PMID 19884654 DOI: 10.1172/JCI40053  1
2009 Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE. Netting neutrophils in autoimmune small-vessel vasculitis. Nature Medicine. 15: 623-5. PMID 19448636 DOI: 10.1038/nm.1959  1
2009 Bengatta S, Arnould C, Letavernier E, Monge M, de Préneuf HM, Werb Z, Ronco P, Lelongt B. MMP9 and SCF protect from apoptosis in acute kidney injury. Journal of the American Society of Nephrology : Jasn. 20: 787-97. PMID 19329763 DOI: 10.1681/ASN.2008050515  1
2009 Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. The Journal of Biological Chemistry. 284: 13792-803. PMID 19297327 DOI: 10.1074/jbc.M900508200  1
2008 Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13467-77. PMID 19074020 DOI: 10.1523/JNEUROSCI.2287-08.2008  1
2008 Lu P, Werb Z. Patterning mechanisms of branched organs. Science (New York, N.Y.). 322: 1506-9. PMID 19056977 DOI: 10.1126/science.1162783  1
2008 Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Disease Models & Mechanisms. 1: 155-67; discussion 1. PMID 19048079 DOI: 10.1242/dmm.000596  1
2008 Nielsen BS, Egeblad M, Rank F, Askautrud HA, Pennington CJ, Pedersen TX, Christensen IJ, Edwards DR, Werb Z, Lund LR. Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression. Plos One. 3: e2959. PMID 18698413 DOI: 10.1371/journal.pone.0002959  1
2008 Lu P, Ewald AJ, Martin GR, Werb Z. Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Developmental Biology. 321: 77-87. PMID 18585375 DOI: 10.1016/j.ydbio.2008.06.005  1
2008 Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne D, Holak TA, Werb Z, Sixt M, Wedlich-Soldner R. Lifeact: a versatile marker to visualize F-actin. Nature Methods. 5: 605-7. PMID 18536722 DOI: 10.1038/nmeth.1220  1
2008 Ewald AJ, Brenot A, Duong M, Chan BS, Werb Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental Cell. 14: 570-81. PMID 18410732 DOI: 10.1016/j.devcel.2008.03.003  1
2008 Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Ewald A, Werb Z, Alonso MA, Mostov K. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Current Biology : Cb. 18: 507-13. PMID 18394894 DOI: 10.1016/j.cub.2008.02.076  1
2008 Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2: 90-102. PMID 18371425 DOI: 10.1016/j.stem.2007.10.002  1
2008 Lu P, Yu Y, Perdue Y, Werb Z. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development (Cambridge, England). 135: 1395-405. PMID 18359901 DOI: 10.1242/dev.018945  1
2008 Kouros-Mehr H, Kim JW, Bechis SK, Werb Z. GATA-3 and the regulation of the mammary luminal cell fate. Current Opinion in Cell Biology. 20: 164-70. PMID 18358709 DOI: 10.1016/  1
2008 Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 13: 206-20. PMID 18328425 DOI: 10.1016/j.ccr.2008.01.034  1
2008 Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 13: 141-52. PMID 18242514 DOI: 10.1016/j.ccr.2008.01.011  1
2008 Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY. CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Research. 68: 506-15. PMID 18199546 DOI: 10.1158/0008-5472.CAN-07-3060  1
2008 Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Werb Z, Alonso MA, Mostov K. Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis (DOI:10.1016/j.cub.2008.02.076) Current Biology. 18: 1016. DOI: 10.1016/j.cub.2008.06.055  1
2008 Littlepage LE, Egeblad M, Werb Z. The Tumor Microenvironment in Cancer Progression The Molecular Basis of Cancer. 229-239. DOI: 10.1016/B978-141603703-3.10017-2  1
2007 Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K. The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell Stem Cell. 1: 658-70. PMID 18371407 DOI: 10.1016/j.stem.2007.10.012  1
2007 Sneddon JB, Werb Z. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 1: 607-11. PMID 18371402 DOI: 10.1016/j.stem.2007.11.009  1
2007 Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. A model of intussusceptive angiogenesis. Novartis Foundation Symposium. 283: 37-42; discussion 42. PMID 18300412  1
2007 Melani C, Sangaletti S, Barazzetta FM, Werb Z, Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Research. 67: 11438-46. PMID 18056472 DOI: 10.1158/0008-5472.CAN-07-1882  1
2007 Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. Plos One. 2: e1150. PMID 17987127 DOI: 10.1371/journal.pone.0001150  1
2007 Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Developmental Cell. 13: 462-3. PMID 17925222 DOI: 10.1016/j.devcel.2007.09.013  1
2007 Fata JE, Mori H, Ewald AJ, Zhang H, Yao E, Werb Z, Bissell MJ. The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Developmental Biology. 306: 193-207. PMID 17448457 DOI: 10.1016/j.ydbio.2007.03.013  1
2007 Egeblad M, Shen HC, Behonick DJ, Wilmes L, Eichten A, Korets LV, Kheradmand F, Werb Z, Coussens LM. Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 1683-93. PMID 17440987 DOI: 10.1002/dvdy.21159  1
2007 Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2580-91. PMID 17392479 DOI: 10.1096/fj.06-7860com  1
2007 Lemieux GA, Blumenkron F, Yeung N, Zhou P, Williams J, Grammer AC, Petrovich R, Lipsky PE, Moss ML, Werb Z. The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. The Journal of Biological Chemistry. 282: 14836-44. PMID 17389606 DOI: 10.1074/jbc.M608414200  1
2007 Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Molecular Biology of the Cell. 18: 1693-700. PMID 17332496 DOI: 10.1091/mbc.E06-11-1052  1
2007 Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nature Reviews. Molecular Cell Biology. 8: 221-33. PMID 17318226 DOI: 10.1038/nrm2125  1
2007 Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. Journal of Mammary Gland Biology and Neoplasia. 12: 37-45. PMID 17286210 DOI: 10.1007/s10911-007-9036-6  1
2007 Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiological Reviews. 87: 69-98. PMID 17237343 DOI: 10.1152/physrev.00022.2006  1
2007 Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Molecular and Cellular Biology. 27: 678-88. PMID 17116694 DOI: 10.1128/MCB.01279-06  1
2006 Yeh MW, Rougier JP, Park JW, Duh QY, Wong M, Werb Z, Clark OH. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocrine-Related Cancer. 13: 1173-83. PMID 17158762 DOI: 10.1677/erc.1.01226  1
2006 Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 127: 1041-55. PMID 17129787 DOI: 10.1016/j.cell.2006.09.048  1
2006 Lu P, Sternlicht MD, Werb Z. Comparative mechanisms of branching morphogenesis in diverse systems. Journal of Mammary Gland Biology and Neoplasia. 11: 213-28. PMID 17120154 DOI: 10.1007/s10911-006-9027-z  1
2006 Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 2107-14. PMID 17119035 DOI: 10.1158/1055-9965.EPI-06-0351  1
2006 Greenlee KJ, Corry DB, Engler DA, Matsunami RK, Tessier P, Cook RG, Werb Z, Kheradmand F. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. Journal of Immunology (Baltimore, Md. : 1950). 177: 7312-21. PMID 17082650  1
2006 Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 235: 3404-12. PMID 17039550 DOI: 10.1002/dvdy.20978  1
2006 Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9841-50. PMID 17005848 DOI: 10.1523/JNEUROSCI.1993-06.2006  1
2006 Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z. Hormonal and local control of mammary branching morphogenesis. Differentiation; Research in Biological Diversity. 74: 365-81. PMID 16916375 DOI: 10.1111/j.1432-0436.2006.00105.x  1
2006 Chaillan FA, Rivera S, Marchetti E, Jourquin J, Werb Z, Soloway PD, Khrestchatisky M, Roman FS. Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behavioural Brain Research. 173: 191-8. PMID 16860884 DOI: 10.1016/j.bbr.2006.06.020  1
2006 Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. The Embo Journal. 25: 2686-97. PMID 16763560 DOI: 10.1038/sj.emboj.7601173  1
2006 Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, ... ... Werb Z, et al. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nature Medicine. 12: 557-67. PMID 16648859 DOI: 10.1038/nm1400  1
2006 Zeisberg M, Khurana M, Rao VH, Cosgrove D, Rougier JP, Werner MC, Shield CF, Werb Z, Kalluri R. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. Plos Medicine. 3: e100. PMID 16509766 DOI: 10.1371/journal.pmed.0030100  1
2006 Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. Bmc Biochemistry. 7: 2. PMID 16417632 DOI: 10.1186/1471-2091-7-2  1
2006 Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. The Journal of Investigative Dermatology. 126: 486-96. PMID 16374453 DOI: 10.1038/sj.jid.5700084  1
2005 Egeblad M, Littlepage LE, Werb Z. The fibroblastic coconspirator in cancer progression. Cold Spring Harbor Symposia On Quantitative Biology. 70: 383-8. PMID 16869775 DOI: 10.1101/sqb.2005.70.007  1
2005 Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia (New York, N.Y.). 7: 1001-10. PMID 16331886 DOI: 10.1593/neo.05496  1
2005 Stickens D, Zak BM, Rougler N, Esko JD, Werb Z. Mice deficient in Ext2 lack heparan sulfate and develop exostoses Development. 132: 5055-5068. PMID 16236767 DOI: 10.1242/dev.02088  1
2005 Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Molecular Biology of the Cell. 16: 5528-37. PMID 16195353 DOI: 10.1091/mbc.E05-02-0128  1
2005 Wall SJ, Werner E, Werb Z, DeClerck YA. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen Journal of Biological Chemistry. 280: 40187-40194. PMID 16186104 DOI: 10.1074/jbc.M508226200  1
2005 Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K. Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization Journal of Experimental Medicine. 202: 739-750. PMID 16157686 DOI: 10.1084/jem.20050959  1
2005 Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival Nature Cell Biology. 7: 870-879. PMID 16113679 DOI: 10.1038/ncb1288  1
2005 Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, Werb Z. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (Cambridge, England). 132: 3923-33. PMID 16079154 DOI: 10.1242/dev.01966  1
2005 Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K. A role for niches in hematopoietic cell development Hematology. 10: 247-253. PMID 16019473 DOI: 10.1080/10245330500067249  1
2005 Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436: 123-7. PMID 16001073 DOI: 10.1038/nature03688  1
2005 Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 9884-9. PMID 15994223 DOI: 10.1073/pnas.0504391102  1
2005 Littlepage LE, Egeblad M, Werb Z. Coevolution of cancer and stromal cellular responses. Cancer Cell. 7: 499-500. PMID 15950897 DOI: 10.1016/j.ccr.2005.05.019  1
2005 Liu Z, Li N, Diaz LA, Shipley M, Senior RM, Werb Z. Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. The Journal of Clinical Investigation. 115: 879-87. PMID 15841177 DOI: 10.1172/JCI23977  1
2005 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z. Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Molecular Biology of the Cell. 16: 3028-39. PMID 15800063 DOI: 10.1091/mbc.E04-12-1119  1
2005 Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 54: 694-701. PMID 15734845 DOI: 10.2337/diabetes.54.3.694  1
2005 Lee MM, Yoon BJ, Osiewicz K, Preston M, Bundy B, Van Heeckeren AM, Werb Z, Soloway PD. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection Infection and Immunity. 73: 661-665. PMID 15618213 DOI: 10.1128/IAI.73.1.661-665.2005  1
2005 Masson V, de la Ballina LR, Munaut C, Wielockx B, Jost M, Maillard C, Blacher S, Bajou K, Itoh T, Itohara S, Werb Z, Libert C, Foidart JM, Noël A. Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 234-6. PMID 15550552 DOI: 10.1096/fj.04-2140fje  1
2004 Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice Development. 131: 5883-5895. PMID 15539485 DOI: 10.1242/dev.01461  1
2004 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. The Journal of Biological Chemistry. 279: 53848-56. PMID 15456762 DOI: 10.1074/jbc.M403114200  1
2004 Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases Current Opinion in Cell Biology. 16: 558-564. PMID 15363807 DOI: 10.1016/  1
2004 Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues Development. 131: 3047-3055. PMID 15163627 DOI: 10.1242/dev.01158  1
2004 Ortega N, Behonick DJ, Werb Z. Matrix remodeling during endochondral ossification Trends in Cell Biology. 14: 86-93. PMID 15102440 DOI: 10.1016/j.tcb.2003.12.003  1
2004 Corry DB, Kiss A, Song LZ, Song L, Xu J, Lee SH, Werb Z, Kheradmand F. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines Faseb Journal. 18: 995-997. PMID 15059974 DOI: 10.1096/fj.03-1412fje  1
2004 Chantrain CF, Shimada H, Jodele S, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment Cancer Research. 64: 1675-1686. PMID 14996727 DOI: 10.1158/0008-5472.CAN-03-0160  1
2004 Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes Breast Cancer Research. 6: 1-11. PMID 14680479  1
2004 Werb Z, Evan G. Oncogenes and cell proliferation: Maintenance of genome integrity, tumor stem cells, and the somatic microenvironment Current Opinion in Genetics and Development. 14: 1-3. DOI: 10.1016/j.gde.2003.12.004  1
2003 Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 15853-8. PMID 14668450 DOI: 10.1073/pnas.2136825100  1
2003 Behonick DJ, Werb Z. A bit of give and take: The relationship between the extracellular matrix and the developing chondrocyte Mechanisms of Development. 120: 1327-1336. PMID 14623441 DOI: 10.1016/j.mod.2003.05.002  1
2003 Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG. Ets2-dependent stromal regulation of mouse mammary tumors. Molecular and Cellular Biology. 23: 8614-25. PMID 14612405 DOI: 10.1128/MCB.23.23.8614-8625.2003  1
2003 Lambert V, Wielockx B, Munaut C, Galopin C, Jost M, Itoh T, Werb Z, Baker A, Libert C, Krell HW, Foidart JM, Noël A, Rakic JM. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization Faseb Journal. 17: 2290-2292. PMID 14563686 DOI: 10.1096/fj.03-0113fje  1
2003 Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. Journal of Neuroscience Research. 74: 227-39. PMID 14515352 DOI: 10.1002/jnr.10759  1
2003 Heissig B, Werb Z, Rafii S, Hattori K. Role of c-kit/Kit ligand signaling in regulating vasculogenesis Thrombosis and Haemostasis. 90: 570-576. PMID 14515175  1
2003 Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S, Werb Z. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. The Journal of Cell Biology. 162: 1123-33. PMID 12975354 DOI: 10.1083/jcb.200302090  1
2003 Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. The Embo Journal. 22: 4794-803. PMID 12970191 DOI: 10.1093/emboj/cdg482  1
2003 Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. Journal of Neurosurgery. 99: 188-97. PMID 12956462  1
2003 Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. Journal of Neuroscience Research. 73: 644-58. PMID 12929132 DOI: 10.1002/jnr.10701  1
2003 Solberg H, Rinkenberger J, Danø K, Werb Z, Lund LR. A functional overlap of plasminogen and MMPs regulates vascularization during placental development Development. 130: 4439-4450. PMID 12900459 DOI: 10.1242/dev.00642  1
2003 Colnot C, Thompson Z, Miclau T, Werb Z, Helms JA. Altered fracture repair in the abscence of MMP9 Development. 130: 4123-4133. PMID 12874132 DOI: 10.1242/dev.00559  1
2003 Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 3: 589-601. PMID 12842087 DOI: 10.1016/S1535-6108(03)00133-8  1
2003 Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R. Role of collagen type II and perlecan in skeletal development. Annals of the New York Academy of Sciences. 995: 140-50. PMID 12814946  1
2003 Ortega N, Behonick D, Stickens D, Werb Z. How proteases regulate bone morphogenesis Annals of the New York Academy of Sciences. 995: 109-116. PMID 12814943  1
2003 Slorach EM, Werb Z. Epithelial morphogenesis: Netrin comes to a sticky and terminal end Current Biology. 13: R491-R493. PMID 12814570 DOI: 10.1016/S0960-9822(03)00411-1  1
2003 Vu TH, Alemayehu Y, Werb Z. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mechanisms of Development. 120: 305-13. PMID 12591600 DOI: 10.1016/S0925-4773(02)00451-3  1
2003 Heissig B, Hattori K, Friedrich M, Rafii S, Werb Z. Angiogenesis: Vascular remodeling of the extracellular matrix involves metalloproteinases Current Opinion in Hematology. 10: 136-141. PMID 12579040 DOI: 10.1097/00062752-200303000-00007  1
2003 Affolter M, Bellusci S, Itoh N, Shilo B, Thiery JP, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Developmental Cell. 4: 11-8. PMID 12530959 DOI: 10.1016/S1534-5807(02)00410-0  1
2003 Nilsen-Hamilton M, Werb Z, Keshet E. Tissue remodeling: Preface Annals of the New York Academy of Sciences. 995: ix-xii.  1
2002 Coussens LM, Werb Z. Inflammation and cancer Nature. 420: 860-867. PMID 12490959 DOI: 10.1038/nature01322  1
2002 Ortega N, Werb Z. New functional roles for non-collagenous domains of basement membrane collagens Journal of Cell Science. 115: 4201-4214. PMID 12376553 DOI: 10.1242/jcs.00106  1
2002 Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. The Journal of Biological Chemistry. 277: 49175-85. PMID 12368295 DOI: 10.1074/jbc.M205131200  1
2002 Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. The American Journal of Pathology. 161: 1429-37. PMID 12368215 DOI: 10.1016/S0002-9440(10)64418-5  1
2002 Lambert V, Munaut C, Jost M, Noël A, Werb Z, Foidart JM, Rakic JM. Matrix metalloproteinase-9 contributes to choroidal neovascularization American Journal of Pathology. 161: 1247-1253. PMID 12368198  1
2002 Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z, Bissell MJ. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell. 2: 205-216. PMID 12242153 DOI: 10.1016/S1535-6108(02)00125-3  1
2002 Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events Journal of Neuroscience. 22: 7526-7535. PMID 12196576  1
2002 Yan Y, Shirakabe K, Werb Z. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors Journal of Cell Biology. 158: 221-226. PMID 12119356  1
2002 Werner E, Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases Journal of Cell Biology. 158: 357-368. PMID 12119354  1
2002 Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MAS, Werb Z, et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment Nature Medicine. 8: 841-849. PMID 12091880 DOI: 10.1038/nm740  1
2002 Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MAS, Werb Z, Rafii S. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand Cell. 109: 625-637. PMID 12062105 DOI: 10.1016/S0092-8674(02)00754-7  1
2002 Wiseman BS, Werb Z. Development: Stromal effects on mammary gland development and breast cancer Science. 296: 1046-1049. PMID 12004111 DOI: 10.1126/science.1067431  1
2002 Lilla J, Stickens D, Werb Z. Metalloproteases and adipogenesis: A weighty subject American Journal of Pathology. 160: 1551-1554. PMID 12000705  1
2002 Welm B, Mott J, Werb Z. Developmental biology: vasculogenesis is a wreck without RECK Current Biology : Cb. 12: R209-211. PMID 11909548  1
2002 Corry DB, Rishi K, Kanellis J, Kiss A, Song Lz LZ, Xu J, Feng L, Werb Z, Kheradmand F. Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nature Immunology. 3: 347-53. PMID 11887181 DOI: 10.1038/ni773  1
2002 Kheradmand F, Rishi K, Werb Z. Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2 Journal of Cell Science. 115: 839-848. PMID 11865039  1
2002 Kheradmand F, Werb Z. Shedding light on sheddases: Role in growth and development Bioessays. 24: 8-12. DOI: 10.1002/bies.10037  1
2002 Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression Nature Reviews Cancer. 2: 161-174.  1
2001 Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ. The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells Development. 128: 3117-3131. PMID 11688561  1
2001 Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior Annual Review of Cell and Developmental Biology. 17: 463-516. PMID 11687497 DOI: 10.1146/annurev.cellbio.17.1.463  1
2001 Chang C, Werb Z. The many faces of metalloproteases: Cell growth, invasion, angiogenesis and metastasis Trends in Cell Biology. 11: S37-S43. PMID 11684441 DOI: 10.1016/S0962-8924(01)02122-5  1
2001 Chen R, Ning G, Zhao ML, Fleming MG, Diaz LA, Werb Z, Liu Z. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. The Journal of Clinical Investigation. 108: 1151-8. PMID 11602622 DOI: 10.1172/JCI11494  1
2001 Werner E, Kheradmand F, Isberg RR, Werb Z. Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade. Journal of Cell Science. 114: 3333-43. PMID 11591821  1
2001 Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia (New York, N.Y.). 3: 339-50. PMID 11571634 DOI: 10.1038/sj/neo/7900170  1
2001 Rougier N, Werb Z. Minireview: Parthenogenesis in mammals Molecular Reproduction and Development. 59: 468-474. PMID 11468784 DOI: 10.1002/mrd.1054  1
1978 Werb Z, Dingle JT, Reynolds JJ, Barrett AJ. Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. The Biochemical Journal. 173: 949-58. PMID 30451  1
1976 Werb Z, Dingle JT. Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. Frontiers of Biology. 45: 127-56. PMID 185097  1
1974 Werb Z, Cohn ZA. The preparation of macrophage lysosomes and phagolysosomes. Methods in Enzymology. 31: 339-45. PMID 4608929  1
1972 Werb Z, Cohn ZA. Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. The Journal of Biological Chemistry. 247: 2439-46. PMID 5019957  1
1972 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. 3. Ingestion and intracellular fate of cholesterol and cholesterol esters. The Journal of Experimental Medicine. 135: 21-44. PMID 4550608  1
1971 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. The Journal of Experimental Medicine. 134: 1545-69. PMID 5126640  1
1971 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. II. Alteration of subcellular exchangeable cholesterol compartments and exchange in other cell types. The Journal of Experimental Medicine. 134: 1570-90. PMID 4942408  1
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