Shahriar Mobashery - Publications

Affiliations: 
Chemistry and Biochemistry University of Notre Dame, Notre Dame, IN, United States 
Area:
bioorganic chemistry, organic synthesis, protein chemistry, enzymology and computational sciences
Website:
http://chemistry.nd.edu/faculty/detail/smobashe/

251 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Speri E, Kim C, De Benedetti S, Qian Y, Lastochkin E, Fishovitz J, Fisher JF, Mobashery S. Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant . Acs Medicinal Chemistry Letters. 10: 1148-1153. PMID 31413798 DOI: 10.1021/acsmedchemlett.9b00169  0.96
2019 Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant . Antimicrobial Agents and Chemotherapy. PMID 30858202 DOI: 10.1128/AAC.02637-18  0.76
2019 Dik DA, Madukoma CS, Tomoshige S, Kim C, Lastochkin E, Boggess WC, Fisher JF, Shrout JD, Mobashery S. Slt, MltD and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of -Lactam Antibiotics. Acs Chemical Biology. PMID 30620575 DOI: 10.1021/acschembio.8b01025  0.96
2018 Speri E, Fishovitz J, Mobashery S. Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant (MRSA). Medchemcomm. 9: 2008-2016. PMID 30746061 DOI: 10.1039/c8md00479j  0.52
2018 Raz L, Yang Y, Thompson J, Hobson S, Pesko J, Mobashery S, Chang M, Rosenberg G. MMP-9 inhibitors impair learning in spontaneously hypertensive rats. Plos One. 13: e0208357. PMID 30533010 DOI: 10.1371/journal.pone.0208357  0.6
2018 Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. Biochemistry. PMID 30256085 DOI: 10.1021/acs.biochem.8b00800  0.96
2018 Fisher JF, Mobashery S. A positive positive to negative. Nature Chemistry. 10: 998-1000. PMID 30237531 DOI: 10.1038/s41557-018-0148-y  0.6
2018 Nguyen TT, Ding D, Wolter WR, Perez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor that Accelerates Healing. Journal of Medicinal Chemistry. PMID 30212201 DOI: 10.1021/acs.jmedchem.8b01005  0.96
2018 Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. In Search of Selectivity in Inhibition of ADAM10. Acs Medicinal Chemistry Letters. 9: 708-713. PMID 30034605 DOI: 10.1021/acsmedchemlett.8b00163  0.76
2018 Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M. Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology. PMID 30012502 DOI: 10.1016/j.ejphar.2018.07.014  0.96
2018 Chen S, Chen Z, Cui J, McCrary ML, Song H, Mobashery S, Chang M, Gu Z. Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice. Eneuro. 5. PMID 29963617 DOI: 10.1523/ENEURO.0391-17.2018  0.6
2018 Ceballos S, Kim C, Ding D, Mobashery S, Chang M, Torres C. Activities of oxadiazole antibacterials against and other Gram-positive bacteria. Antimicrobial Agents and Chemotherapy. PMID 29866865 DOI: 10.1128/AAC.00453-18  0.96
2018 Dik DA, Fisher JF, Mobashery S. Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance. Chemical Reviews. PMID 29847102 DOI: 10.1021/acs.chemrev.8b00277  0.84
2018 Tomoshige S, Dik DA, Akabane-Nakata M, Madukoma C, Fisher JF, Shrout JD, Mobashery S. Total Syntheses of Bulgecins A, B and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics. Acs Infectious Diseases. PMID 29716193 DOI: 10.1021/acsinfecdis.8b00105  0.84
2018 Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S. Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of . Proceedings of the National Academy of Sciences of the United States of America. PMID 29632171 DOI: 10.1073/pnas.1801298115  0.96
2018 Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Scientific Reports. 8: 4110. PMID 29515200 DOI: 10.1038/s41598-018-22527-y  0.84
2018 Kim C, Hesek D, Lee M, Mobashery S. Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 29402738 DOI: 10.1016/j.bmcl.2018.01.028  0.96
2018 Bernardo-Garcia N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. Acs Chemical Biology. PMID 29357220 DOI: 10.1021/acschembio.7b00817  0.96
2017 Lee M, Hesek D, Zajíček J, Fisher JF, Mobashery S. Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol. Chemical Communications (Cambridge, England). PMID 29139490 DOI: 10.1039/c7cc06781j  0.96
2017 Domínguez-Gil T, Molina R, Dik DA, Spink E, Mobashery S, Hermoso JA. The X-ray Structure of Catenated Lytic Transglycosylase SltB1. Biochemistry. PMID 29131935 DOI: 10.1021/acs.biochem.7b00932  0.84
2017 Horsman ME, Marous DR, Li R, Oliver RA, Byun B, Emrich SJ, Boggess B, Townsend CA, Mobashery S. Whole-Genome Shotgun Sequencing and Comparison of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster. Acs Chemical Biology. PMID 28937735 DOI: 10.1021/acschembio.7b00687  0.84
2017 Dik DA, Marous DR, Fisher JF, Mobashery S. Lytic transglycosylases: concinnity in concision of the bacterial cell wall. Critical Reviews in Biochemistry and Molecular Biology. 1-40. PMID 28644060 DOI: 10.1080/10409238.2017.1337705  0.84
2017 Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. Acs Medicinal Chemistry Letters. 8: 654-659. PMID 28626528 DOI: 10.1021/acsmedchemlett.7b00130  0.76
2017 Mobashery S, Lee M, Hesek D, Lastochkin E, Boggess B, Dik DA. Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Wall. Chembiochem : a European Journal of Chemical Biology. PMID 28591487 DOI: 10.1002/cbic.201700293  0.96
2017 Acebron I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S. Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 28482153 DOI: 10.1021/jacs.7b01626  0.96
2017 Lee M, Hesek D, Dik DA, Fishovitz J, Lastochkin E, Boggess B, Fisher JF, Mobashery S. From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa. Angewandte Chemie (International Ed. in English). PMID 28128504 DOI: 10.1002/anie.201611279  0.96
2017 Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S. Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis. Journal of the American Chemical Society. PMID 28099001 DOI: 10.1021/jacs.6b12565  0.76
2017 Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF. Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure (London, England : 1993). PMID 28089449 DOI: 10.1016/j.str.2016.12.007  0.96
2017 Dik DA, Dominguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess W, Hellman LM, Fisher JF, Hermoso JA, Mobashery S. Muropeptide Binding and the X-Ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 28079369 DOI: 10.1021/jacs.6b12819  0.96
2016 Fisher JF, Mobashery S. Endless Resistance. Endless Antibiotics? Medchemcomm. 7: 37-49. PMID 27746889 DOI: 10.1039/C5MD00394F  0.6
2016 An DR, Im HN, Jang JY, Kim HS, Kim J, Yoon HJ, Hesek D, Lee M, Mobashery S, Kim SJ, Suh SW. Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori. Plos One. 11: e0164243. PMID 27711177 DOI: 10.1371/journal.pone.0164243  1
2016 Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S. Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. Angewandte Chemie (International Ed. in English). 55: 12568. PMID 27676218 DOI: 10.1002/anie.201608482  1
2016 Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA. Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 27618662 DOI: 10.1016/j.str.2016.07.019  1
2016 Schaub RE, Chan YA, Lee M, Hesek D, Mobashery S, Dillard JP. Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling, and releasing peptidoglycan in Neisseria gonorrhoeae. Molecular Microbiology. PMID 27608412 DOI: 10.1111/mmi.13496  0.96
2016 Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S. Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27599239 DOI: 10.1021/acschembio.6b00756  0.96
2016 Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M. Selective inhibition of MMP-2 does not alter neurological recovery after spinal cord injury. Acs Chemical Neuroscience. PMID 27551907 DOI: 10.1021/acschemneuro.6b00217  0.76
2016 Janardhanan J, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mobashery S, Chang M. In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams. Antimicrobial Agents and Chemotherapy. PMID 27401567 DOI: 10.1128/AAC.00787-16  1
2016 Rivera I, Molina R, Lee M, Mobashery S, Hermoso JA. Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria. Microbial Drug Resistance (Larchmont, N.Y.). PMID 27326855 DOI: 10.1089/mdr.2016.0083  0.96
2016 Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, Achour A. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity. Molecular Microbiology. PMID 27273793 DOI: 10.1111/mmi.13435  0.96
2016 Janardhanan J, Chang M, Mobashery S. The oxadiazole antibacterials. Current Opinion in Microbiology. 33: 13-17. PMID 27239942 DOI: 10.1016/j.mib.2016.05.009  1
2016 Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S. Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. Angewandte Chemie (International Ed. in English). PMID 27111486 DOI: 10.1002/anie.201601693  1
2016 Fisher JF, Mobashery S. β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis. Cold Spring Harbor Perspectives in Medicine. PMID 27091943 DOI: 10.1101/cshperspect.a025221  1
2016 Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. Journal of Medicinal Chemistry. PMID 27088777 DOI: 10.1021/acs.jmedchem.6b00372  1
2016 Wang H, Hesek D, Lee M, Lastochkin E, Oliver AG, Chang M, Mobashery S. The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity. Journal of Natural Products. PMID 27049333 DOI: 10.1021/acs.jnatprod.6b00057  1
2016 Lee M, Dominguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S. Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27035839 DOI: 10.1021/acschembio.6b00194  0.96
2016 Lenz JD, Stohl EA, Robertson R, Hackett KT, Fisher K, Xiong K, Lee M, Hesek D, Mobashery S, Seifert HS, Davies C, Dillard JP. Amidase Activity of AmiC Controls Cell Separation, Stem-peptide Release, and is Enhanced by NlpD in Neisseria gonorrhoeae. The Journal of Biological Chemistry. PMID 26984407 DOI: 10.1074/jbc.M116.715573  1
2016 Fisher JF, Mobashery S. Endless resistance. Endless antibiotics? Medchemcomm. 7: 37-49. DOI: 10.1039/c5md00394f  1
2016 Gooyit M, Peng Z, Mobashery S, Chang M. Chapter 10: Thiirane class of gelatinase inhibitors as a privileged template that crosses the blood-brain barrier Rsc Drug Discovery Series. 2016: 262-286. DOI: 10.1039/9781782622246-00262  1
2016 Fisher JF, Mobashery S. Chapter 3: The b-lactam (azetidin-2-one) as a privileged ring in medicinal chemistry Rsc Drug Discovery Series. 2016: 64-97. DOI: 10.1039/9781782622246-00064  1
2015 Boudreau MA, Fishovitz J, Llarrull LI, Xiao Q, Mobashery S. Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules. Acs Infectious Diseases. 1: 454-9. PMID 27623311 DOI: 10.1021/acsinfecdis.5b00086  0.52
2015 Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S. Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. Bioorganic & Medicinal Chemistry Letters. PMID 26733473 DOI: 10.1016/j.bmcl.2015.12.041  1
2015 Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598687 DOI: 10.1073/pnas.1517847112  0.6
2015 Rico-Lastres P, Díez-Martínez R, Iglesias-Bexiga M, Bustamante N, Aldridge C, Hesek D, Lee M, Mobashery S, Gray J, Vollmer W, García P, Menéndez M. Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence. Scientific Reports. 5: 16198. PMID 26537571 DOI: 10.1038/srep16198  1
2015 Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CD, Mobashery S, Chang M, Dantas G. Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA. Nature Chemical Biology. 11: 855-861. PMID 26368589 DOI: 10.1038/nchembio.1911  0.6
2015 Kim HS, Im HN, An DR, Yoon JY, Jang JY, Mobashery S, Hesek D, Lee M, Yoo J, Cui M, Choi S, Kim C, Lee NK, Kim SJ, Kim JY, et al. The Cell-Shape Determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase. The Journal of Biological Chemistry. PMID 26306031 DOI: 10.1074/jbc.M115.658781  1
2015 Lee M, Chen Z, Tomlinson BN, Gooyit M, Hesek D, Juarez MR, Nizam R, Boggess B, Lastochkin E, Schroeder VA, Wolter WR, Suckow MA, Cui J, Mobashery S, Gu Z, et al. Water-soluble MMP-9 inhibitor reduces lesion volume after severe traumatic brain injury. Acs Chemical Neuroscience. PMID 26241578 DOI: 10.1021/acschemneuro.5b00140  1
2015 Lee M, Rucil T, Hesek D, Oliver AG, Fisher JF, Mobashery S. Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles. The Journal of Organic Chemistry. 80: 7757-63. PMID 26154983 DOI: 10.1021/acs.joc.5b01044  1
2015 Galimand M, Fishovitz J, Lambert T, Barbe V, Zajicek J, Mobashery S, Courvalin P. AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum. Antimicrobial Agents and Chemotherapy. 59: 5647-53. PMID 26149994 DOI: 10.1128/AAC.01203-15  0.52
2015 Ding D, Boudreau MA, Leemans E, Spink E, Yamaguchi T, Testero SA, O'Daniel PI, Lastochkin E, Chang M, Mobashery S. Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics. Bioorganic & Medicinal Chemistry Letters. PMID 26144346 DOI: 10.1016/j.bmcl.2015.06.044  1
2015 Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV. The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. Open Biology. 5: 150025. PMID 26136255 DOI: 10.1098/rsob.150025  1
2015 Fishovitz J, Taghizadeh N, Fisher JF, Chang M, Mobashery S. The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of the American Chemical Society. 137: 6500-5. PMID 25964995 DOI: 10.1021/jacs.5b01374  1
2015 Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium. Journal of Medicinal Chemistry. 58: 4194-203. PMID 25923368 DOI: 10.1021/jm501831g  1
2015 An DR, Kim HS, Kim J, Im HN, Yoon HJ, Yoon JY, Jang JY, Hesek D, Lee M, Mobashery S, Kim SJ, Lee BI, Suh SW. Structure of Csd3 from Helicobacter pylori, a cell shape-determining metallopeptidase. Acta Crystallographica. Section D, Biological Crystallography. 71: 675-86. PMID 25760614 DOI: 10.1107/S1399004715000152  1
2015 Acebrón I, Chang M, Mobashery S, Hermoso JA. The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus. Current Medicinal Chemistry. 22: 1678-86. PMID 25760091  1
2015 Staude MW, Frederick TE, Natarajan SV, Wilson BD, Tanner CE, Ruggiero ST, Mobashery S, Peng JW. Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus. Biochemistry. 54: 1600-10. PMID 25658195 DOI: 10.1021/bi501463k  1
2015 Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. Journal of the American Chemical Society. 137: 1738-41. PMID 25629446 DOI: 10.1021/jacs.5b00056  1
2015 Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O'Daniel PI, Testero SA, Pi H, Schroeder VA, Wolter WR, Antunes NT, Suckow MA, ... ... Mobashery S, et al. Structure-activity relationship for the oxadiazole class of antibiotics. Journal of Medicinal Chemistry. 58: 1380-9. PMID 25590813 DOI: 10.1021/jm501661f  1
2015 Lee M, Hesek D, Blázquez B, Lastochkin E, Boggess B, Fisher JF, Mobashery S. Catalytic spectrum of the penicillin-binding protein 4 of Pseudomonas aeruginosa, a nexus for the induction of β-lactam antibiotic resistance. Journal of the American Chemical Society. 137: 190-200. PMID 25495032 DOI: 10.1021/ja5111706  1
2015 Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel proteaseanti-protease combination therapy Proceedings of the National Academy of Sciences of the United States of America. 112: 15226-15231. DOI: 10.1073/pnas.1517847112/-/DCSupplemental  1
2015 Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CAD, Mobashery S, Chang M, Dantas G. Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA Nature Chemical Biology. DOI: 10.1038/nchembio.1911  1
2014 Kim HS, Kim J, Im HN, An DR, Lee M, Hesek D, Mobashery S, Kim JY, Cho K, Yoon HJ, Han BW, Lee BI, Suh SW. Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling the helical cell shape. Acta Crystallographica. Section D, Biological Crystallography. 70: 2800-12. PMID 25372672 DOI: 10.1107/S1399004714018732  1
2014 Lee M, Hesek D, Noll BC, Oliver AG, Mobashery S. Enantiomers of a selective gelatinase inhibitor: (R)- and (S)-2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane. Acta Crystallographica. Section C, Structural Chemistry. 70: 1003-6. PMID 25370094 DOI: 10.1107/S2053229614021214  1
2014 Xiao Q, Vakulenko S, Chang M, Mobashery S. Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 58: 5841-7. PMID 25049248 DOI: 10.1128/AAC.03501-14  1
2014 Fishovitz J, Hermoso JA, Chang M, Mobashery S. Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Iubmb Life. 66: 572-7. PMID 25044998 DOI: 10.1002/iub.1289  1
2014 Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA. Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. Acs Chemical Biology. 9: 2058-66. PMID 24988330 DOI: 10.1021/cb500439c  1
2014 Fishovitz J, Rojas-Altuve A, Otero LH, Dawley M, Carrasco-López C, Chang M, Hermoso JA, Mobashery S. Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics. Journal of the American Chemical Society. 136: 9814-7. PMID 24955778 DOI: 10.1021/ja5030657  1
2014 Fisher JF, Mobashery S. The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa. Bioorganic Chemistry. 56: 41-8. PMID 24955547 DOI: 10.1016/j.bioorg.2014.05.011  1
2014 Blázquez B, Llarrull LI, Luque-Ortega JR, Alfonso C, Boggess B, Mobashery S. Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA). Biochemistry. 53: 1548-50. PMID 24564530 DOI: 10.1021/bi500074w  1
2014 Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A. Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae. Mbio. 5: e01120-13. PMID 24520066 DOI: 10.1128/mBio.01120-13  1
2014 O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, ... ... Mobashery S, et al. Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. Journal of the American Chemical Society. 136: 3664-72. PMID 24517363 DOI: 10.1021/ja500053x  1
2014 Fu HL, Valiathan RR, Payne L, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Fridman R. Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1). The Journal of Biological Chemistry. 289: 9275-87. PMID 24509848 DOI: 10.1074/jbc.M113.541102  1
2014 Kumarasiri M, Zhang W, Shi Q, Fisher JF, Mobashery S. Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications. Proteins. 82: 1348-58. PMID 24375650 DOI: 10.1002/prot.24501  1
2014 Frederick TE, Wilson BD, Cha J, Mobashery S, Peng JW. Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy. Biochemistry. 53: 10-2. PMID 24359467 DOI: 10.1021/bi401552j  1
2014 Gooyit M, Peng Z, Wolter WR, Pi H, Ding D, Hesek D, Lee M, Boggess B, Champion MM, Suckow MA, Mobashery S, Chang M. A chemical biological strategy to facilitate diabetic wound healing. Acs Chemical Biology. 9: 105-10. PMID 24053680 DOI: 10.1021/cb4005468  1
2014 Ding D, Lichtenwalter K, Pi H, Mobashery S, Chang M. Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8) Medchemcomm. 5: 1381-1383. DOI: 10.1039/c4md00172a  1
2013 Jedinak L, Rush L, Lee M, Hesek D, Fisher JF, Boggess B, Noll BC, Mobashery S. Use of silver carbonate in the Wittig reaction. The Journal of Organic Chemistry. 78: 12224-8. PMID 24251875 DOI: 10.1021/jo401972a  1
2013 Hadass O, Tomlinson BN, Gooyit M, Chen S, Purdy JJ, Walker JM, Zhang C, Giritharan AB, Purnell W, Robinson CR, Shin D, Schroeder VA, Suckow MA, Simonyi A, Sun GY, ... Mobashery S, et al. Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. Plos One. 8: e76904. PMID 24194849 DOI: 10.1371/journal.pone.0076904  1
2013 Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proceedings of the National Academy of Sciences of the United States of America. 110: 16808-13. PMID 24085846 DOI: 10.1073/pnas.1300118110  1
2013 Gooyit M, Song W, Mahasenan KV, Lichtenwalter K, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. Journal of Medicinal Chemistry. 56: 8139-50. PMID 24028490 DOI: 10.1021/jm401217d  1
2013 Smith CA, Antunes NT, Stewart NK, Toth M, Kumarasiri M, Chang M, Mobashery S, Vakulenko SB. Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. Chemistry & Biology. 20: 1107-15. PMID 24012371 DOI: 10.1016/j.chembiol.2013.07.015  1
2013 Lee M, Artola-Recolons C, Carrasco-López C, Martínez-Caballero S, Hesek D, Spink E, Lastochkin E, Zhang W, Hellman LM, Boggess B, Hermoso JA, Mobashery S. Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 12604-7. PMID 23931161 DOI: 10.1021/ja407445x  1
2013 Martínez-Caballero S, Lee M, Artola-Recolons C, Carrasco-López C, Hesek D, Spink E, Lastochkin E, Zhang W, Hellman LM, Boggess B, Mobashery S, Hermoso JA. Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 10318-21. PMID 23819763 DOI: 10.1021/ja405464b  1
2013 Smith JD, Kumarasiri M, Zhang W, Hesek D, Lee M, Toth M, Vakulenko S, Fisher JF, Mobashery S, Chen Y. Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in β-lactam resistance. Antimicrobial Agents and Chemotherapy. 57: 3137-46. PMID 23629710 DOI: 10.1128/AAC.00505-13  1
2013 Fu HL, Sohail A, Valiathan RR, Wasinski BD, Kumarasiri M, Mahasenan KV, Bernardo MM, Tokmina-Roszyk D, Fields GB, Mobashery S, Fridman R. Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases. The Journal of Biological Chemistry. 288: 12114-29. PMID 23519472 DOI: 10.1074/jbc.M112.409599  1
2013 Zhang W, Lee M, Hesek D, Lastochkin E, Boggess B, Mobashery S. Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 4950-3. PMID 23510438 DOI: 10.1021/ja400970n  1
2013 Lee M, Hesek D, Llarrull LI, Lastochkin E, Pi H, Boggess B, Mobashery S. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Journal of the American Chemical Society. 135: 3311-4. PMID 23421439 DOI: 10.1021/ja309036q  1
2013 Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R. Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. The Journal of Biological Chemistry. 288: 7430-7. PMID 23335507 DOI: 10.1074/jbc.R112.444158  1
2013 Johnson JW, Fisher JF, Mobashery S. Bacterial cell-wall recycling. Annals of the New York Academy of Sciences. 1277: 54-75. PMID 23163477 DOI: 10.1111/j.1749-6632.2012.06813.x  1
2013 Kumarasiri M, Fisher JF, Mobashery S. Penicillin-Binding Protein 5 of Escherichia coli Handbook of Proteolytic Enzymes. 3: 3474-3480. DOI: 10.1016/B978-0-12-382219-2.00770-5  1
2013 Leemans E, Fisher JF, Mobashery S. The β-lactam antibiotics: Their future in the face of resistance Antimicrobials: New and Old Molecules in the Fight Against Multi-Resistant Bacteria. 59-84. DOI: 10.1007/978-3-642-39968-8_4  1
2012 Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe K, Munoz J, Mobashery S, Vakulenko SB. Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases. Journal of the American Chemical Society. 134: 19512-5. PMID 23148776 DOI: 10.1021/ja308197j  1
2012 Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. Acs Chemical Neuroscience. 3: 730-6. PMID 23077716 DOI: 10.1021/cn300062w  1
2012 Mazel D, Mobashery S. Antibiotics as physiological stress inducers and bacterial response to the challenge. Current Opinion in Microbiology. 15: 553-4. PMID 23063065 DOI: 10.1016/j.mib.2012.09.002  1
2012 Hesek D, Lee M, Zají?ek J, Fisher JF, Mobashery S. Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol. Journal of the American Chemical Society. 134: 13881-8. PMID 22861066 DOI: 10.1021/ja306184m  1
2012 Yamaguchi T, Blázquez B, Hesek D, Lee M, Llarrull LI, Boggess B, Oliver AG, Fisher JF, Mobashery S. Inhibitors for Bacterial Cell-Wall Recycling. Acs Medicinal Chemistry Letters. 3: 238-242. PMID 22844551 DOI: 10.1021/ml2002746  1
2012 Makino H, Tada Y, Wada K, Liang EI, Chang M, Mobashery S, Kanematsu Y, Kurihara C, Palova E, Kanematsu M, Kitazato K, Hashimoto T. Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study. Stroke; a Journal of Cerebral Circulation. 43: 2450-6. PMID 22798328 DOI: 10.1161/STROKEAHA.112.659821  1
2012 Lee M, Ikejiri M, Klimpel D, Toth M, Espahbodi M, Hesek D, Forbes C, Kumarasiri M, Noll BC, Chang M, Mobashery S. Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors. Acs Medicinal Chemistry Letters. 3: 490-495. PMID 22737278 DOI: 10.1021/ml300050b  1
2012 Llarrull LI, Mobashery S. Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus. Biochemistry. 51: 4642-9. PMID 22616850 DOI: 10.1021/bi300429p  1
2012 Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R, Hadass O, Lehmidi T, Blair GJ, Lee M, Chang M, Mobashery S, Sun GY, Gu Z. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Molecular Neurodegeneration. 7: 21. PMID 22587708 DOI: 10.1186/1750-1326-7-21  1
2012 Boudreau MA, Fisher JF, Mobashery S. Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry. 51: 2974-90. PMID 22409164 DOI: 10.1021/bi300174x  1
2012 Kumarasiri M, Llarrull LI, Borbulevych O, Fishovitz J, Lastochkin E, Baker BM, Mobashery S. An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases. The Journal of Biological Chemistry. 287: 8232-41. PMID 22262858 DOI: 10.1074/jbc.M111.333179  1
2012 Park JS, Lee WC, Yeo KJ, Ryu KS, Kumarasiri M, Hesek D, Lee M, Mobashery S, Song JH, Kim SI, Lee JC, Cheong C, Jeon YH, Kim HY. Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 219-28. PMID 21965596 DOI: 10.1096/fj.11-188425  1
2011 Testero SA, Lee M, Staran RT, Espahbodi M, Llarrull LI, Toth M, Mobashery S, Chang M. Sulfonate-containing thiiranes as selective gelatinase inhibitors. Acs Medicinal Chemistry Letters. 2: 177-81. PMID 24900296 DOI: 10.1021/ml100254e  1
2011 Llarrull LI, Toth M, Champion MM, Mobashery S. Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance. The Journal of Biological Chemistry. 286: 38148-58. PMID 21896485 DOI: 10.1074/jbc.M111.288985  1
2011 Gooyit M, Lee M, Schroeder VA, Ikejiri M, Suckow MA, Mobashery S, Chang M. Selective water-soluble gelatinase inhibitor prodrugs. Journal of Medicinal Chemistry. 54: 6676-90. PMID 21866961 DOI: 10.1021/jm200566e  1
2011 Sohail A, Marco M, Zhao H, Shi Q, Merriman S, Mobashery S, Fridman R. Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase. The Journal of Biological Chemistry. 286: 33178-89. PMID 21828052 DOI: 10.1074/jbc.M111.253369  1
2011 Borbulevych O, Kumarasiri M, Wilson B, Llarrull LI, Lee M, Hesek D, Shi Q, Peng J, Baker BM, Mobashery S. Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. The Journal of Biological Chemistry. 286: 31466-72. PMID 21775440 DOI: 10.1074/jbc.M111.252189  1
2011 Carrasco-López C, Rojas-Altuve A, Zhang W, Hesek D, Lee M, Barbe S, André I, Ferrer P, Silva-Martin N, Castro GR, Martínez-Ripoll M, Mobashery S, Hermoso JA. Crystal structures of bacterial peptidoglycan amidase AmpD and an unprecedented activation mechanism. The Journal of Biological Chemistry. 286: 31714-22. PMID 21775432 DOI: 10.1074/jbc.M111.264366  1
2011 Antunes NT, Frase H, Toth M, Mobashery S, Vakulenko SB. Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism. Biochemistry. 50: 6387-95. PMID 21696166 DOI: 10.1021/bi200403e  1
2011 Shi Q, Meroueh SO, Fisher JF, Mobashery S. A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. Journal of the American Chemical Society. 133: 5274-83. PMID 21417389 DOI: 10.1021/ja1074739  1
2011 Frase H, Smith CA, Toth M, Champion MM, Mobashery S, Vakulenko SB. Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. The Journal of Biological Chemistry. 286: 14396-409. PMID 21345789 DOI: 10.1074/jbc.M110.208744  1
2011 Artola-Recolons C, Carrasco-López C, Llarrull LI, Kumarasiri M, Lastochkin E, Martínez de Ilarduya I, Meindl K, Usón I, Mobashery S, Hermoso JA. High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. Biochemistry. 50: 2384-6. PMID 21341761 DOI: 10.1021/bi200085y  1
2011 Testero SA, Bouley R, Fisher JF, Chang M, Mobashery S. Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases. Bioorganic & Medicinal Chemistry Letters. 21: 2675-8. PMID 21256011 DOI: 10.1016/j.bmcl.2010.12.076  1
2011 Artola-Recolons C, Llarrull LI, Lastochkin E, Mobashery S, Hermoso JA. Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 161-3. PMID 21206052 DOI: 10.1107/S1744309110049171  1
2011 Maestro B, Novaková L, Hesek D, Lee M, Leyva E, Mobashery S, Sanz JM, Branny P. Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. Febs Letters. 585: 357-63. PMID 21167155 DOI: 10.1016/j.febslet.2010.12.016  1
2011 Chongsiriwatana NP, Miller TM, Wetzler M, Vakulenko S, Karlsson AJ, Palecek SP, Mobashery S, Barron AE. Short alkylated peptoid mimics of antimicrobial lipopeptides. Antimicrobial Agents and Chemotherapy. 55: 417-20. PMID 20956607 DOI: 10.1128/AAC.01080-10  1
2011 Benson HL, Mobashery S, Chang M, Kheradmand F, Hong JS, Smith GN, Shilling RA, Wilkes DS. Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. American Journal of Respiratory Cell and Molecular Biology. 44: 700-8. PMID 20639459 DOI: 10.1165/rcmb.2010-0125OC  1
2011 Testero SA, Llarrull LI, Fisher JF, Chang M, Mobashery S. Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry Arkivoc. 2011: 221-236.  1
2010 Lee M, Hesek D, Shah IM, Oliver AG, Dworkin J, Mobashery S. Synthetic peptidoglycan motifs for germination of bacterial spores. Chembiochem : a European Journal of Chemical Biology. 11: 2525-9. PMID 21117117 DOI: 10.1002/cbic.201000626  1
2010 Zhou J, Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB. QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. Journal of Chemical Theory and Computation. 6: 3580-3587. PMID 21076643 DOI: 10.1021/ct100382k  1
2010 Llarrull LI, Testero SA, Fisher JF, Mobashery S. The future of the β-lactams. Current Opinion in Microbiology. 13: 551-7. PMID 20888287 DOI: 10.1016/j.mib.2010.09.008  1
2010 Llarrull LI, Prorok M, Mobashery S. Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. Biochemistry. 49: 7975-7. PMID 20722402 DOI: 10.1021/bi101177a  1
2010 Fisher JF, Mobashery S. Host-guest chemistry of the peptidoglycan. Journal of Medicinal Chemistry. 53: 4813-29. PMID 20524613 DOI: 10.1021/jm100086u  1
2010 Bernal P, Lemaire S, Pinho MG, Mobashery S, Hinds J, Taylor PW. Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. The Journal of Biological Chemistry. 285: 24055-65. PMID 20516078 DOI: 10.1074/jbc.M110.114793  1
2010 Pérez-Dorado I, González A, Morales M, Sanles R, Striker W, Vollmer W, Mobashery S, García JL, Martínez-Ripoll M, García P, Hermoso JA. Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. Nature Structural & Molecular Biology. 17: 576-81. PMID 20400948 DOI: 10.1038/nsmb.1817  1
2010 Yamaguchi T, Hesek D, Lee M, Oliver AG, Mobashery S. Sulfonylation-induced N- to O-acetyl migration in 2-acetamidoethanol derivatives. The Journal of Organic Chemistry. 75: 3515-7. PMID 20361802 DOI: 10.1021/jo100456z  1
2010 O'Daniel PI, Zajicek J, Zhang W, Shi Q, Fisher JF, Mobashery S. Elucidation of the structure of the membrane anchor of penicillin-binding protein 5 of Escherichia coli. Journal of the American Chemical Society. 132: 4110-8. PMID 20192190 DOI: 10.1021/ja9094445  1
2010 Fisher JF, Mobashery S. Mechanism-based profiling of MMPs. Methods in Molecular Biology (Clifton, N.J.). 622: 471-87. PMID 20135299 DOI: 10.1007/978-1-60327-299-5_27  1
2010 Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB. Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT. The Journal of Physical Chemistry. B. 114: 1030-7. PMID 20039633 DOI: 10.1021/jp909327y  1
2010 Toth M, Smith C, Frase H, Mobashery S, Vakulenko S. An antibiotic-resistance enzyme from a deep-sea bacterium. Journal of the American Chemical Society. 132: 816-23. PMID 20000704 DOI: 10.1021/ja908850p  1
2010 Fernández D, Testero S, Vendrell J, Avilés FX, Mobashery S. The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor. Chemical Biology & Drug Design. 75: 29-34. PMID 19895506 DOI: 10.1111/j.1747-0285.2009.00907.x  1
2010 Fisher JF, Mobashery S. Enzymology of bacterial resistance Comprehensive Natural Products Ii: Chemistry and Biology. 8: 443-487.  1
2009 Gooyit M, Lee M, Hesek D, Boggess B, Oliver AG, Fridman R, Mobashery S, Chang M. Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors. Chemical Biology & Drug Design. 74: 535-46. PMID 19824893 DOI: 10.1111/j.1747-0285.2009.00898.x  1
2009 Forbes C, Shi Q, Fisher JF, Lee M, Hesek D, Llarrull LI, Toth M, Gossing M, Fridman R, Mobashery S. Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases. Chemical Biology & Drug Design. 74: 527-34. PMID 19807733 DOI: 10.1111/j.1747-0285.2009.00881.x  1
2009 Chen Y, Zhang W, Shi Q, Hesek D, Lee M, Mobashery S, Shoichet BK. Crystal structures of penicillin-binding protein 6 from Escherichia coli. Journal of the American Chemical Society. 131: 14345-54. PMID 19807181 DOI: 10.1021/ja903773f  1
2009 Tao P, Fisher JF, Shi Q, Vreven T, Mobashery S, Schlegel HB. Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. Biochemistry. 48: 9839-47. PMID 19754151 DOI: 10.1021/bi901118r  1
2009 Frase H, Shi Q, Testero SA, Mobashery S, Vakulenko SB. Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases. The Journal of Biological Chemistry. 284: 29509-13. PMID 19656947 DOI: 10.1074/jbc.M109.011262  1
2009 Zhang W, Fisher JF, Mobashery S. The bifunctional enzymes of antibiotic resistance. Current Opinion in Microbiology. 12: 505-11. PMID 19615931 DOI: 10.1016/j.mib.2009.06.013  1
2009 Fisher JF, Mobashery S. Three decades of the class A beta-lactamase acyl-enzyme. Current Protein & Peptide Science. 10: 401-7. PMID 19538154 DOI: 10.2174/138920309789351967  1
2009 Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A, Hashimoto T. Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1547-58. PMID 19513084 DOI: 10.1038/jcbfm.2009.77  1
2009 Lee M, Zhang W, Hesek D, Noll BC, Boggess B, Mobashery S. Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. Journal of the American Chemical Society. 131: 8742-3. PMID 19496566 DOI: 10.1021/ja9025566  1
2009 Llarrull LI, Fisher JF, Mobashery S. Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrobial Agents and Chemotherapy. 53: 4051-63. PMID 19470504 DOI: 10.1128/AAC.00084-09  1
2009 Testero SA, O'Daniel PI, Shi Q, Lee M, Hesek D, Ishiwata A, Noll BC, Mobashery S. Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases. Organic Letters. 11: 2515-8. PMID 19445490 DOI: 10.1021/ol900668k  1
2009 Tao P, Fisher JF, Mobashery S, Schlegel HB. DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2. Organic Letters. 11: 2559-62. PMID 19445474 DOI: 10.1021/ol9008393  1
2009 Hesek D, Lee M, Zhang W, Noll BC, Mobashery S. Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. Journal of the American Chemical Society. 131: 5187-93. PMID 19309146 DOI: 10.1021/ja808498m  1
2009 Hesek D, Lee M, Noll BC, Fisher JF, Mobashery S. Complications from dual roles of sodium hydride as a base and as a reducing agent. The Journal of Organic Chemistry. 74: 2567-70. PMID 19215116 DOI: 10.1021/jo802706d  1
2009 Lee M, Celenza G, Boggess B, Blase J, Shi Q, Toth M, Bernardo MM, Wolter WR, Suckow MA, Hesek D, Noll BC, Fridman R, Mobashery S, Chang M. A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition. Chemical Biology & Drug Design. 73: 189-202. PMID 19207421 DOI: 10.1111/j.1747-0285.2008.00750.x  1
2009 Molina R, González A, Stelter M, Pérez-Dorado I, Kahn R, Morales M, Moscoso M, Campuzano S, Campillo NE, Mobashery S, García JL, García P, Hermoso JA. Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae. Embo Reports. 10: 246-51. PMID 19165143 DOI: 10.1038/embor.2008.245  1
2009 Toth M, Chow JW, Mobashery S, Vakulenko SB. Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. The Journal of Biological Chemistry. 284: 6690-6. PMID 19158087 DOI: 10.1074/jbc.M808148200  1
2009 Lee M, Hesek D, Noll BC, Mobashery S. Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group Chemical Papers. 63: 592-597. DOI: 10.2478/s11696-009-0048-0  1
2009 Hesek D, Lee M, Zhang W, Noll BC, Mobashery S. Total synthesis of N-acetylglucosamine-1,6-anhydro-N- acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli (Journal of the American Chemical Society (2009) 131, (5187-5193)) Journal of the American Chemical Society. 131: 10334. DOI: 10.1021/ja904230q  1
2008 Zhao H, Sohail A, Sun Q, Shi Q, Kim S, Mobashery S, Fridman R. Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25). The Journal of Biological Chemistry. 283: 35023-32. PMID 18936094 DOI: 10.1074/jbc.M806553200  1
2008 Bonfil RD, Fridman R, Mobashery S, Cher ML. Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis? Current Oncology (Toronto, Ont.). 15: 188-92. PMID 18769612  1
2008 Suvorov M, Lee M, Hesek D, Boggess B, Mobashery S. Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. Journal of the American Chemical Society. 130: 11878-9. PMID 18700763 DOI: 10.1021/ja805482b  1
2008 Hesek D, Lee M, Yamaguchi T, Noll BC, Mobashery S. Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline. The Journal of Organic Chemistry. 73: 7349-52. PMID 18690743 DOI: 10.1021/jo801037z  1
2008 Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Research. 68: 6251-9. PMID 18676849 DOI: 10.1158/0008-5472.CAN-08-0537  1
2008 Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S. Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. Journal of the American Chemical Society. 130: 9212-3. PMID 18582062 DOI: 10.1021/ja8029448  1
2008 Shi Q, Meroueh SO, Fisher JF, Mobashery S. Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations. Journal of the American Chemical Society. 130: 9293-303. PMID 18576637 DOI: 10.1021/ja801727k  1
2008 Lemaire S, Fuda C, Van Bambeke F, Tulkens PM, Mobashery S. Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics by acidic pH: Role of penicillin-binding protein PBP Journal of Biological Chemistry. 283: 12769-12776. PMID 18337244 DOI: 10.1074/jbc.M800079200  1
2008 Totir MA, Cha J, Ishiwata A, Wang B, Sheri A, Anderson VE, Buynak J, Mobashery S, Carey PR. Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry. 47: 4094-101. PMID 18324783 DOI: 10.1021/bi702348w  1
2008 Celenza G, Villegas-Estrada A, Lee M, Boggess B, Forbes C, Wolter WR, Suckow MA, Mobashery S, Chang M. Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor. Chemical Biology & Drug Design. 71: 187-96. PMID 18221479 DOI: 10.1111/j.1747-0277.2008.00632.x  1
2008 Badarau A, Shi Q, Chow JW, Zajicek J, Mobashery S, Vakulenko S. Aminoglycoside 2″-phosphotransferase type IIIa from Enterococcus Journal of Biological Chemistry. 283: 7638-7647. PMID 18199745 DOI: 10.1074/jbc.M709645200  1
2008 Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA. Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 208-16. PMID 18171938 DOI: 10.1523/JNEUROSCI.3674-07.2008  1
2008 Lee M, Hesek D, Shi Q, Noll BC, Fisher JF, Chang M, Mobashery S. Conformational analyses of thiirane-based gelatinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3064-7. PMID 18083555 DOI: 10.1016/j.bmcl.2007.11.131  1
2008 Lee M, Hesek D, Mobashery S. Synthetic efforts in preparations of components of the bacterial cell wall Acs Symposium Series. 990: 54-78. DOI: 10.1021/bk-2008-0990.ch003  1
2007 Brickner SJ, Mobashery S. Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus Current Opinion in Microbiology. 10: 425-427. PMID 17951102 DOI: 10.1016/j.mib.2007.09.002  1
2007 Rosenblum G, Meroueh S, Toth M, Fisher JF, Fridman R, Mobashery S, Sagi I. Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: Challenging the cysteine switch dogma Journal of the American Chemical Society. 129: 13566-13574. PMID 17929919 DOI: 10.1021/ja073941l  1
2007 Lee M, Villegas-Estrada A, Celenza G, Boggess B, Toth M, Kreitinger G, Forbes C, Fridman R, Mobashery S, Chang M. Metabolism of a highly selective gelatinase inhibitor generates active metabolite. Chemical Biology & Drug Design. 70: 371-82. PMID 17927722 DOI: 10.1111/j.1747-0285.2007.00577.x  1
2007 Zhang W, Shi Q, Meroueh SO, Vakulenko SB, Mobashery S. Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli Biochemistry. 46: 10113-10121. PMID 17685588 DOI: 10.1021/bi700777x  1
2007 Pérez-Dorado I, Campillo NE, Monterroso B, Hesek D, Lee M, Páez JA, García P, Martínez-Ripoll M, García JL, Mobashery S, Menéndez M, Hermoso JA. Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1 Journal of Biological Chemistry. 282: 24990-24999. PMID 17581815 DOI: 10.1074/jbc.M704317200  1
2007 Kling D, Hesek D, Shi Q, Mobashery S. Design and synthesis of a structurally constrained aminoglycoside. The Journal of Organic Chemistry. 72: 5450-3. PMID 17579461 DOI: 10.1021/jo0707636  1
2007 Fuda C, Suvorov M, Shi Q, Hesek D, Lee M, Mobashery S. Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Biochemistry. 46: 8050-7. PMID 17567045 DOI: 10.1021/bi7004587  1
2007 Cha J, Vakulenko SB, Mobashery S. Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. Biochemistry. 46: 7822-31. PMID 17550272 DOI: 10.1021/bi7005459  1
2007 Meroueh SO, Mobashery S. Conformational transition in the aminoacyl t-RNA site of the bacterial ribosome both in the presence and absence of an aminoglycoside antibiotic Chemical Biology and Drug Design. 69: 291-297. PMID 17539821 DOI: 10.1111/j.1747-0285.2007.00505.x  1
2007 Bonfil RD, Dong Z, Trindade Filho JC, Sabbota A, Osenkowski P, Nabha S, Yamamoto H, Chinni SR, Zhao H, Mobashery S, Vessella RL, Fridman R, Cher ML. Prostate cancer-associated membrane type 1-matrix metalloproteinase: A pivotal role in bone response and intraosseous tumor growth American Journal of Pathology. 170: 2100-2111. PMID 17525276 DOI: 10.2353/ajpath.2007.060720  1
2007 Cho S, Wang Q, Swaminathan CP, Hesek D, Lee M, Boons GJ, Mobashery S, Mariuzza RA. Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 8761-6. PMID 17502600 DOI: 10.1073/pnas.0701453104  1
2007 Suvorov M, Vakulenko SB, Mobashery S. Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance. Antimicrobial Agents and Chemotherapy. 51: 2937-42. PMID 17502412 DOI: 10.1128/AAC.00011-07  1
2007 Toth M, Zajicek J, Kim C, Chow JW, Smith C, Mobashery S, Vakulenko S. Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib. Biochemistry. 46: 5570-8. PMID 17425289 DOI: 10.1021/bi6024512  1
2007 Kim C, Villegas-Estrada A, Hesek D, Mobashery S. Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. Biochemistry. 46: 5270-82. PMID 17417880 DOI: 10.1021/bi700111z  1
2007 Cha J, Mobashery S. Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. Journal of the American Chemical Society. 129: 3834-5. PMID 17343387 DOI: 10.1021/ja070472e  1
2007 Rosenberg GA, Estrada EY, Mobashery S. Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents Brain Research. 1133: 186-192. PMID 17184743 DOI: 10.1016/j.brainres.2006.11.041  1
2007 Kling D, Chow C, Mobashery S. Binding of Antibiotics to the Aminoacyl-Trna Site of Bacterial Ribosome Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery. 225-233. DOI: 10.1002/9780470149676.ch7  1
2006 Toth M, Sohail A, Mobashery S, Fridman R. MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts Biochemical and Biophysical Research Communications. 350: 377-384. PMID 17007816 DOI: 10.1016/j.bbrc.2006.09.052  1
2006 Hesek D, Toth M, Krchňák V, Fridman R, Mobashery S. Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease Journal of Organic Chemistry. 71: 5848-5854. PMID 16872162 DOI: 10.1021/jo060058h  1
2006 Kim C, Hesek D, Zajícek J, Vakulenko SB, Mobashery S. Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. Biochemistry. 45: 8368-77. PMID 16819836 DOI: 10.1021/bi060723g  1
2006 Thumanu K, Cha J, Fisher JF, Perrins R, Mobashery S, Wharton C. Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proceedings of the National Academy of Sciences of the United States of America. 103: 10630-5. PMID 16815972 DOI: 10.1073/pnas.0601971103  1
2006 Rekharsky M, Hesek D, Lee M, Meroueh SO, Inoue Y, Mobashery S. Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall Journal of the American Chemical Society. 128: 7736-7737. PMID 16771477 DOI: 10.1021/ja061828+  1
2006 Fisher JF, Mobashery S. Recent advances in MMP inhibitor design Cancer and Metastasis Reviews. 25: 115-136. PMID 16680577 DOI: 10.1007/s10555-006-7894-9  1
2006 Hesek D, Toth M, Meroueh SO, Brown S, Zhao H, Sakr W, Fridman R, Mobashery S. Design and Characterization of a Metalloproteinase Inhibitor-Tethered Resin for the Detection of Active MMPs in Biological Samples Chemistry and Biology. 13: 379-386. PMID 16632250 DOI: 10.1016/j.chembiol.2006.01.012  1
2006 Hesek D, Noll BC, Mobashery S. Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors Journal of Organic Chemistry. 71: 2885-2887. PMID 16555848 DOI: 10.1021/jo052546f  1
2006 Meroueh SO, Bencze KZ, Hesek D, Lee M, Fisher JF, Stemmler TL, Mobashery S. Three-dimensional structure of the bacterial cell wall peptidoglycan. Proceedings of the National Academy of Sciences of the United States of America. 103: 4404-9. PMID 16537437 DOI: 10.1073/pnas.0510182103  1
2006 Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S. Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. Chemistry & Biology. 13: 129-38. PMID 16492561 DOI: 10.1016/j.chembiol.2005.11.004  1
2006 Fuda C, Hesek D, Lee M, Heilmayer W, Novak R, Vakulenko SB, Mobashery S. Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus Journal of Biological Chemistry. 281: 10035-10041. PMID 16459335 DOI: 10.1074/jbc.M508846200  1
2006 Kim C, Cha JY, Yan H, Vakulenko SB, Mobashery S. Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme. The Journal of Biological Chemistry. 281: 6964-9. PMID 16407230 DOI: 10.1074/jbc.M513257200  1
2006 Bonfil RD, Sabbota A, Nabha S, Bernardo MM, Dong Z, Meng H, Yamamoto H, Chinni SR, Lim IT, Chang M, Filetti LC, Mobashery S, Cher ML, Fridman R. Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor. International Journal of Cancer. Journal International Du Cancer. 118: 2721-6. PMID 16381009 DOI: 10.1002/ijc.21645  1
2006 Fisher JF, Meroueh SO, Mobashery S. Nanomolecular and supramolecular paths toward peptidoglycan structure Microbe. 1: 420-427.  1
2005 Cross JB, Vreven T, Meroueh SO, Mobashery S, Schlegel HB. Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A. The Journal of Physical Chemistry. B. 109: 4761-9. PMID 16851559 DOI: 10.1021/jp0455172  1
2005 Meroueh SO, Fisher JF, Schlegel HB, Mobashery S. Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. Journal of the American Chemical Society. 127: 15397-407. PMID 16262403 DOI: 10.1021/ja051592u  1
2005 Lee M, Bernardo MM, Meroueh SO, Brown S, Fridman R, Mobashery S. Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors Organic Letters. 7: 4463-4465. PMID 16178559 DOI: 10.1021/ol0517269  1
2005 Fuda CC, Fisher JF, Mobashery S. Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome. Cellular and Molecular Life Sciences : Cmls. 62: 2617-33. PMID 16143832 DOI: 10.1007/s00018-005-5148-6  1
2005 Li J, Cross JB, Vreven T, Meroueh SO, Mobashery S, Schlegel HB. Lysine carboxylation in proteins: OXA-10 beta-lactamase. Proteins. 61: 246-57. PMID 16121396 DOI: 10.1002/prot.20596  1
2005 Ikejiri M, Bernardo MM, Bonfil RD, Toth M, Chang M, Fridman R, Mobashery S. Potent mechanism-based inhibitors for matrix metalloproteinases. The Journal of Biological Chemistry. 280: 33992-4002. PMID 16046398 DOI: 10.1074/jbc.M504303200  1
2005 Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6401-8. PMID 16000631 DOI: 10.1523/JNEUROSCI.1563-05.2005  1
2005 Ikejiri M, Bernardo MM, Meroueh SO, Brown S, Chang M, Fridman R, Mobashery S. Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A. The Journal of Organic Chemistry. 70: 5709-12. PMID 15989356 DOI: 10.1021/jo050339+  1
2005 Thomas VL, Golemi-Kotra D, Kim C, Vakulenko SB, Mobashery S, Shoichet BK. Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. Biochemistry. 44: 9330-8. PMID 15981999 DOI: 10.1021/bi0502700  1
2005 Osenkowski P, Meroueh SO, Pavel D, Mobashery S, Fridman R. Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing Journal of Biological Chemistry. 280: 26160-26168. PMID 15901740 DOI: 10.1074/jbc.M414379200  1
2005 Kim C, Mobashery S. Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance. Bioorganic Chemistry. 33: 149-58. PMID 15888308 DOI: 10.1016/j.bioorg.2004.11.001  1
2005 Krüger A, Arlt MJ, Gerg M, Kopitz C, Bernardo MM, Chang M, Mobashery S, Fridman R. Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Research. 65: 3523-6. PMID 15867341 DOI: 10.1158/0008-5472.CAN-04-3570  1
2005 Fuda C, Hesek D, Lee M, Morio KI, Nowak T, Mobashery S. Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall Journal of the American Chemical Society. 127: 2056-2057. PMID 15713078 DOI: 10.1021/ja0434376  1
2005 Fisher JF, Meroueh SO, Mobashery S. Bacterial resistance to β-lactam antibiotics: Compelling opportunism, compelling opportunity Chemical Reviews. 105: 395-424. PMID 15700950 DOI: 10.1021/cr030102i  1
2005 Lee M, Hesek D, Mobashery S. A practical synthesis of nitrocefin Journal of Organic Chemistry. 70: 367-369. PMID 15624952 DOI: 10.1021/jo0487395  1
2005 Toth M, Osenkowski P, Hesek D, Brown S, Meroueh S, Sakr W, Mobashery S, Fridman R. Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase Biochemical Journal. 387: 497-506. PMID 15560752 DOI: 10.1042/BJ20041324  1
2004 Birck C, Cha JY, Cross J, Schulze-Briese C, Meroueh SO, Schlegel HB, Mobashery S, Samama JP. X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. Journal of the American Chemical Society. 126: 13945-7. PMID 15506754 DOI: 10.1021/ja044742u  1
2004 Lee M, Fridman R, Mobashery S. Extracellular proteases as targets for treatment of cancer metastases Chemical Society Reviews. 33: 401-409. PMID 15354221 DOI: 10.1039/b209224g  1
2004 Brown S, Meroueh SO, Fridman R, Mobashery S. Quest for selectivity in inhibition of matrix metalloproteinases Current Topics in Medicinal Chemistry. 4: 1227-1238. PMID 15320723 DOI: 10.2174/1568026043387854  1
2004 Lim IT, Meroueh SO, Lee M, Heeg MJ, Mobashery S. Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis Journal of the American Chemical Society. 126: 10271-10277. PMID 15315439 DOI: 10.1021/ja0489240  1
2004 Fuda C, Suvorov M, Vakulenko SB, Mobashery S. The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. The Journal of Biological Chemistry. 279: 40802-6. PMID 15226303 DOI: 10.1074/jbc.M403589200  1
2004 Golemi-Kotra D, Meroueh SO, Kim C, Vakulenko SB, Bulychev A, Stemmler AJ, Stemmler TL, Mobashery S. The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins. The Journal of Biological Chemistry. 279: 34665-73. PMID 15152012 DOI: 10.1074/jbc.M313143200  1
2004 Lim IT, Brown S, Mobashery S. A Convenient Synthesis of a Selective Gelatinase Inhibitor as an Antimetastatic Agent Journal of Organic Chemistry. 69: 3572-3573. PMID 15132575 DOI: 10.1021/jo049857v  1
2004 Solomon A, Rosenblum G, Gonzales PE, Leonard JD, Mobashery S, Milla ME, Sagi I. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-α-converting enzyme and matrix metalloproteinases despite their high structural similarity Journal of Biological Chemistry. 279: 31646-31654. PMID 15102849 DOI: 10.1074/jbc.M401310200  1
2004 Hesek D, Lee M, Morio KI, Mobashery S. Synthesis of a Fragment of Bacterial Cell Wall Journal of Organic Chemistry. 69: 2137-2146. PMID 15058963 DOI: 10.1021/jo035583k  1
2004 Kim C, Haddad J, Vakulenko SB, Meroueh SO, Wu Y, Yan H, Mobashery S. Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. Biochemistry. 43: 2373-83. PMID 14992574 DOI: 10.1021/bi036095+  1
2004 Hesek D, Suvorov M, Morio K, Lee M, Brown S, Vakulenko SB, Mobashery S. Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. The Journal of Organic Chemistry. 69: 778-84. PMID 14750804 DOI: 10.1021/jo035397e  1
2004 Cha JY, Ishiwata A, Mobashery S. A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin. The Journal of Biological Chemistry. 279: 14917-21. PMID 14747460 DOI: 10.1074/jbc.M400666200  1
2003 Lee M, Hesek D, Suvorov M, Lee W, Vakulenko S, Mobashery S. A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins. Journal of the American Chemical Society. 125: 16322-6. PMID 14692773 DOI: 10.1021/ja038445l  1
2003 Richard JP, Mobashery S. Mechanisms: Complex biological processes and their central chemical events Current Opinion in Chemical Biology. 7: 525-527. PMID 14580553 DOI: 10.1016/j.cbpa.2003.08.015  1
2003 Meroueh SO, Minasov G, Lee W, Shoichet BK, Mobashery S. Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. Journal of the American Chemical Society. 125: 9612-8. PMID 12904027 DOI: 10.1021/ja034861u  1
2003 Vakulenko SB, Mobashery S. Versatility of aminoglycosides and prospects for their future Clinical Microbiology Reviews. 16: 430-450. PMID 12857776 DOI: 10.1128/CMR.16.3.430-450.2003  1
2003 Fridman R, Toth M, Chvyrkova I, Meroueh SO, Mobashery S. Cell surface association of matrix metalloproteinase-9 (gelatinase B) Cancer and Metastasis Reviews. 22: 153-166. PMID 12784994 DOI: 10.1023/A:1023091214123  1
2003 Rosenblum G, Meroueh SO, Kleifeld O, Brown S, Singson SP, Fridman R, Mobashery S, Sagi I. Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2) Journal of Biological Chemistry. 278: 27009-27015. PMID 12679334 DOI: 10.1074/jbc.M301139200  1
2003 Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S. The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. Journal of the American Chemical Society. 125: 3410-1. PMID 12643685 DOI: 10.1021/ja029736h  1
2003 Golemi-Kotra D, Cha JY, Meroueh SO, Vakulenko SB, Mobashery S. Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. The Journal of Biological Chemistry. 278: 18419-25. PMID 12591921 DOI: 10.1074/jbc.M300611200  1
2003 Wilkinson AS, Bryant PK, Meroueh SO, Page MG, Mobashery S, Wharton CW. A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations. Biochemistry. 42: 1950-7. PMID 12590581 DOI: 10.1021/bi0266941  1
2002 Kotra LP, Zhang L, Fridman R, Orlando R, Mobashery S. N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9. Bioorganic Chemistry. 30: 356-70. PMID 12485595 DOI: 10.1016/S0045-2068(02)00501-1  1
2002 Vakulenko SB, Golemi D, Geryk B, Suvorov M, Knox JR, Mobashery S, Lerner SA. Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime. Antimicrobial Agents and Chemotherapy. 46: 1966-70. PMID 12019116 DOI: 10.1128/AAC.46.6.1966-1970.2002  1
2002 Haddad J, Kotra LP, Llano-Sotelo B, Kim C, Azucena EF, Liu M, Vakulenko SB, Chow CS, Mobashery S. Design of novel antibiotics that bind to the ribosomal acyltransfer site. Journal of the American Chemical Society. 124: 3229-37. PMID 11916405 DOI: 10.1021/ja011695m  1
2002 Golemi D, Maveyraud L, Haddad J, Lee W, Ishiwata A, Miyashita K, Mourey L, Vakulenko S, Kotra L, Samama JP, Mobashery S. Antibacterials as wonder drugs and how their effectiveness is being compromised Pharmacochemistry Library. 32: 193-205. DOI: 10.1016/S0165-7208(02)80020-4  1
1990 Mobashery S, Doughty M, Kaiser ET. Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator. Biopolymers. 29: 131-8. PMID 2328282 DOI: 10.1002/bip.360290118  1
1990 Mobashery S, Ghosh SS, Tamura SY, Kaiser ET. Design of an effective mechanism-based inactivator for a zinc protease. Proceedings of the National Academy of Sciences of the United States of America. 87: 578-82. PMID 2300547  1
1989 Radziejewski C, Miller WT, Mobashery S, Goldberg AR, Kaiser ET. Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. Biochemistry. 28: 9047-52. PMID 2481500  1
1988 Mobashery S, Kaiser ET. Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. Biochemistry. 27: 3691-6. PMID 3408721  1
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