R. Kip Guy, PhD - Publications

Affiliations: 
1998-2005 Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
 2005-2016 Chemical Biology and Therapeutics St Jude Children's Research Hospital, New York, NY, United States 
 2016- Pharmaceutical Sciences University of Kentucky, Lexington, KY 
Area:
Medicinal Chemistry
Website:
http://pharmacy.uky.edu/faculty/rkgu223/Rodney-Guy

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Eagon S, Hammill JT, Sigal MS, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice A, Falade M, ... ... Guy RK, et al. Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. Journal of Medicinal Chemistry. PMID 32945666 DOI: 10.1021/acs.jmedchem.0c01152  1
2020 Slavish PJ, Chi L, Yun MK, Tsurkan L, Martinez NE, Jonchere B, Chai SC, Connelly M, Waddell MB, Das S, Neale G, Li Z, Shadrick WR, Olsen RR, Freeman KW, ... ... Guy RK, et al. Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer. Cancer Research. PMID 32651255 DOI: 10.1158/0008-5472.CAN-19-3934  1
2019 Kim HS, Hammill JT, Scott DC, Chen Y, Min J, Rector J, Singh B, Schulman BA, Guy RK. Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Journal of Medicinal Chemistry. PMID 31465221 DOI: 10.1021/acs.jmedchem.9b00410  1
2019 Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein D, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. Acs Chemical Biology. PMID 31251562 DOI: 10.1021/acschembio.9b00488  1
2019 Drenberg CD, Shelat A, Dang J, Cotton A, Orwick SJ, Li M, Jeon JY, Fu Q, Buelow DR, Pioso M, Hu S, Inaba H, Ribeiro RC, Rubnitz JE, Gruber TA, ... Guy RK, et al. A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML. Nature Communications. 10: 2189. PMID 31097698 DOI: 10.1038/s41467-019-09917-0  1
2018 Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Häcker H. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Science Signaling. 11. PMID 30108181 DOI: 10.1126/scisignal.aaq1077  1
2018 Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29871975 DOI: 10.1042/BSR20180231_COR  1
2018 Mathew B, Snowden TS, Connelly MC, Guy RK, Reynolds RC. A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. PMID 29776741 DOI: 10.1016/j.bmcl.2018.05.023  1
2018 Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC. Oxazole and thiazole analogs of sulindac for cancer prevention. Future Medicinal Chemistry. PMID 29671617 DOI: 10.4155/fmc-2017-0182  1
2018 Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547696 DOI: 10.1021/acs.jmedchem.7b01277  1
2018 Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547693 DOI: 10.1021/acs.jmedchem.7b01282  1
2018 Teitz T, Fang J, Goktug AN, Bonga JD, Diao S, Hazlitt RA, Iconaru L, Morfouace M, Currier D, Zhou Y, Umans RA, Taylor MR, Cheng C, Min J, Freeman B, ... ... Guy RK, et al. CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. The Journal of Experimental Medicine. PMID 29514916 DOI: 10.1084/jem.20172246  1
2018 Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC. Amine Containing Analogs of Sulindac for Cancer Prevention. The Open Medicinal Chemistry Journal. 12: 1-12. PMID 29492166 DOI: 10.2174/1874104501812010001  1
2018 Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29472314 DOI: 10.1042/BSR20180231  1
2018 Nimmervoll B, Boulos N, Bianski BM, Dapper J, DeCuypere M, Shelat AA, Terranova S, Terhune HE, Gajjar A, Patel YT, Freeman BB, Onar-Thomas A, Stewart CF, Roussel MF, Guy RK, et al. Establishing A Preclinical Multidisciplinary Board for Brain Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29301833 DOI: 10.1158/1078-0432.CCR-17-2168  1
2017 Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, et al. Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Plos Neglected Tropical Diseases. 11: e0006157. PMID 29287089 DOI: 10.1371/journal.pntd.0006157  1
2017 Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein DB, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. Acs Chemical Biology. PMID 28787124 DOI: 10.1021/acschembio.7b00527  1
2017 Yang J, Milasta S, Hu D, AlTahan A, Interiano R, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani A, Wang R, Wang Y, Ong SS, ... ... Guy RK, et al. Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Research. PMID 28684529 DOI: 10.1158/0008-5472.CAN-16-0826  1
2017 Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, ... ... Guy RK, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature Chemical Biology. PMID 28581483 DOI: 10.1038/nchembio.2386  1
2017 Jarusiewicz JA, Jeon JY, Connelly MC, Chen Y, Yang L, Baker SD, Guy RK. Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. Acs Omega. 2: 1985-2009. PMID 28580438 DOI: 10.1021/acsomega.7b00144  1
2017 Bharatham N, Finch KE, Min J, Mayasundari A, Dyer MA, Guy RK, Bashford D. Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx. Journal of Molecular Graphics & Modelling. 74: 54-60. PMID 28351017 DOI: 10.1016/j.jmgm.2017.02.014  1
2017 Kim HS, Hammill JT, Guy RK. Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). Journal of Medicinal Chemistry. PMID 28296396 DOI: 10.1021/acs.jmedchem.7b00299  1
2017 Verras A, Waller CL, Gedeck P, Green D, Kogej T, Raichurkar AV, Panda M, Shelat AA, Clark JA, Guy RK, Papadatos G, Burrows JN. Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition. Journal of Chemical Information and Modeling. PMID 28257198 DOI: 10.1021/acs.jcim.6b00572  1
2016 Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, ... ... Guy RK, et al. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Acs Central Science. 2: 687-701. PMID 27800551 DOI: 10.1021/acscentsci.6b00086  1
2016 Mathew B, Hobrath JV, Ross L, Connelly MC, Lofton H, Rajagopalan M, Guy RK, Reynolds RC. Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. Plos One. 11: e0164100. PMID 27768711 DOI: 10.1371/journal.pone.0164100  1
2016 Danelius E, Pettersson M, Bred M, Min J, Waddell MB, Guy RK, Grøtli M, Erdelyi M. Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins. Organic & Biomolecular Chemistry. PMID 27731454 DOI: 10.1039/c6ob01510g  1
2016 Floyd DM, Stein P, Wang Z, Liu J, Castro S, Clark JA, Connelly MC, Zhu F, Holbrook G, Matheny A, Sigal MS, Min J, Dhinakara R, Krishnan S, Bashyam S, ... ... Guy RK, et al. Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides. Journal of Medicinal Chemistry. PMID 27505686 DOI: 10.1021/acs.jmedchem.6b00752  1
2016 Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Guy RK, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/journal.ppat.1005763  1
2016 Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, ... ... Guy RK, et al. Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum. Malaria Journal. 15: 270. PMID 27165106 DOI: 10.1186/s12936-016-1313-7  1
2016 Drenberg CD, Buaboonnam J, Orwick SJ, Hu S, Li L, Fan Y, Shelat AA, Guy RK, Rubnitz J, Baker SD. Evaluation of artemisinins for the treatment of acute myeloid leukemia. Cancer Chemotherapy and Pharmacology. PMID 27125973 DOI: 10.1007/s00280-016-3038-2  1
2015 Bruhn DF, Wyllie S, Rodríguez-Cortés A, Carrillo AK, Rakesh, Guy K, Fairlam AH, Lee RE. Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes. The Journal of Antimicrobial Chemotherapy. PMID 26682963 DOI: 10.1093/jac/dkv417  1
2015 Min J, Guo K, Suryadevara PK, Zhu F, Holbrook G, Chen Y, Feau C, Young BM, Lemoff A, Connelly MC, Kastan MB, Guy RK. Optimization of a Novel Series of Ataxia-Telangiectasia Mutated (ATM) Kinase Inhibitors as Potential Radiosensitizing Agents. Journal of Medicinal Chemistry. PMID 26632965 DOI: 10.1021/acs.jmedchem.5b01092  1
2015 Pettersson M, Quant M, Min J, Iconaru L, Kriwacki RW, Waddell MB, Guy RK, Luthman K, Grøtli M. Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction. Plos One. 10: e0137867. PMID 26427060 DOI: 10.1371/journal.pone.0137867  1
2015 Ravu RR, Jacob MR, Jeffries C, Tu Y, Khan SI, Agarwal AK, Guy RK, Walker LA, Clark AM, Li XC. LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia. Journal of Natural Products. PMID 26371504 DOI: 10.1021/acs.jnatprod.5b00470  1
2015 Churchman ML, Low J, Qu C, Paietta EM, Kasper LH, Chang Y, Payne-Turner D, Althoff MJ, Song G, Chen SC, Ma J, Rusch M, McGoldrick D, Edmonson M, Gupta P, ... ... Guy RK, et al. Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia. Cancer Cell. 28: 343-56. PMID 26321221 DOI: 10.1016/j.ccell.2015.07.016  1
2015 Pritchard EM, Dyer MA, Guy RK. Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma. Mini Reviews in Medicinal Chemistry. PMID 26202204  1
2015 Pettersson M, Bliman D, Jacobsson J, Nilsson JR, Min J, Iconaru L, Guy RK, Kriwacki RW, Andréasson J, Grøtli M. 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction. Plos One. 10: e0124423. PMID 25942498 DOI: 10.1371/journal.pone.0124423  1
2015 Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, ... ... Guy RK, et al. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nature Genetics. 47: 607-14. PMID 25938942 DOI: 10.1038/ng.3283  1
2015 Ortiz D, Guiguemde WA, Johnson A, Elya C, Anderson J, Clark J, Connelly M, Yang L, Min J, Sato Y, Guy RK, Landfear SM. Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds. Plos One. 10: e0123598. PMID 25894322 DOI: 10.1371/journal.pone.0123598  1
2015 Carrillo AK, Guiguemde WA, Guy RK. Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorganic & Medicinal Chemistry. PMID 25637120 DOI: 10.1016/j.bmc.2014.12.066  1
2015 Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC. Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen. Antimicrobial Agents and Chemotherapy. 59: 1389-97. PMID 25512421 DOI: 10.1128/AAC.01930-13  1
2015 Brennan RC, Pritchard EM, Guy RK, Dyer MA, Wilson MW. Current and emerging therapy for improving outcomes in patients with intraocular retinoblastoma Expert Opinion On Orphan Drugs. DOI: 10.1517/21678707.2015.1075878  0.6
2014 Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, ... ... Guy RK, et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proceedings of the National Academy of Sciences of the United States of America. 111: E5455-62. PMID 25453091 DOI: 10.1073/pnas.1414221111  1
2014 Barnett DS, Guy RK. Antimalarials in Development in 2014. Chemical Reviews. PMID 25340626 DOI: 10.1021/cr500543f  1
2014 Vara BA, Mayasundari A, Tellis JC, Danneman MW, Arredondo V, Davis TA, Min J, Finch K, Guy RK, Johnston JN. Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition. The Journal of Organic Chemistry. 79: 6913-38. PMID 25017623 DOI: 10.1021/jo501003r  1
2014 Guiguemde WA, Hunt NH, Guo J, Marciano A, Haynes RK, Clark J, Guy RK, Golenser J. Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses. Antimicrobial Agents and Chemotherapy. 58: 4745-54. PMID 24913162 DOI: 10.1128/AAC.01553-13  1
2014 Pritchard EM, Stewart E, Zhu F, Bradley C, Griffiths L, Yang L, Suryadevara PK, Zhang J, Freeman BB, Guy RK, Dyer MA. Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma. Pharmaceutical Research. 31: 3060-72. PMID 24906597 DOI: 10.1007/s11095-014-1399-y  1
2014 Lotharius J, Gamo-Benito FJ, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, Parkinson T, Viswanath P, Bandodkar B, Rautela N, Bharath S, Duffy S, Avery VM, Möhrle JJ, Guy RK, et al. Repositioning: the fast track to new anti-malarial medicines? Malaria Journal. 13: 143. PMID 24731288 DOI: 10.1186/1475-2875-13-143  1
2014 Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF, Keiser J, Vennerstrom JL. Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. The American Journal of Tropical Medicine and Hygiene. 90: 1156-8. PMID 24686741 DOI: 10.4269/ajtmh.14-0029  1
2014 Morfouace M, Shelat A, Jacus M, Freeman BB, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, ... Guy RK, et al. Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Cancer Cell. 25: 516-29. PMID 24684846 DOI: 10.1016/j.ccr.2014.02.009  1
2014 Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, ... Guy RK, et al. UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. Journal of Natural Products. 77: 902-9. PMID 24617915 DOI: 10.1021/np4009706  1
2014 Guo K, Shelat AA, Guy RK, Kastan MB. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. Journal of Biomolecular Screening. 19: 538-46. PMID 24464432 DOI: 10.1177/1087057113520325  1
2014 Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy J. Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. Antimicrobial Agents and Chemotherapy. 58: 1516-22. PMID 24366746 DOI: 10.1128/AAC.02148-13  1
2014 Singh H, Shelat AA, Singh A, Boulos N, Williams RT, Guy RK. A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia. Journal of Biomolecular Screening. 19: 158-67. PMID 23989453 DOI: 10.1177/1087057113501081  0.44
2013 Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. Plos One. 8: e82962. PMID 24391728 DOI: 10.1371/journal.pone.0082962  1
2013 Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, ... ... Guy RK, et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Science Translational Medicine. 5: 177ra37. PMID 23515079 DOI: 10.1126/scitranslmed.3005029  1
2013 Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry. 56: 2850-60. PMID 23484493 DOI: 10.1021/jm301687p  1
2013 Hwang JY, Attia RR, Carrillo AK, Connelly MC, Guy RK. Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Bioorganic & Medicinal Chemistry Letters. 23: 1891-5. PMID 23414840 DOI: 10.1016/j.bmcl.2012.12.055  1
2013 Zhang L, Fourches D, Sedykh A, Zhu H, Golbraikh A, Ekins S, Clark J, Connelly MC, Sigal M, Hodges D, Guiguemde A, Guy RK, Tropsha A. Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening. Journal of Chemical Information and Modeling. 53: 475-92. PMID 23252936 DOI: 10.1021/ci300421n  1
2013 Cloete TT, Krebs HJ, Clark JA, Connelly MC, Orcutt A, Sigal MS, Guy RK, N'Da DD. Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin. Bioorganic Chemistry. 46: 10-6. PMID 23247255 DOI: 10.1016/j.bioorg.2012.10.002  1
2012 Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, ... ... Guy RK, et al. Lead optimization of antimalarial propafenone analogues. Journal of Medicinal Chemistry. 55: 6087-93. PMID 22708838 DOI: 10.1021/jm300286a  1
2012 Guiguemde WA, Guy RK. An all-purpose antimalarial drug target. Cell Host & Microbe. 11: 555-7. PMID 22704614 DOI: 10.1016/j.chom.2012.05.008  1
2012 Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. Plos One. 7: e37518. PMID 22675482 DOI: 10.1371/journal.pone.0037518  1
2012 Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. Journal of Medicinal Chemistry. 55: 4640-51. PMID 22563729 DOI: 10.1021/jm300460c  1
2012 Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, ... Guy RK, et al. Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. Journal of Medicinal Chemistry. 55: 4205-19. PMID 22435599 DOI: 10.1021/jm201642z  1
2012 Hwang JY, Attia RR, Zhu F, Yang L, Lemoff A, Jeffries C, Connelly MC, Guy RK. Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. Journal of Medicinal Chemistry. 55: 2301-10. PMID 22324546 DOI: 10.1021/jm201546m  1
2012 Guiguemde WA, Shelat AA, Garcia-Bustos JF, Diagana TT, Gamo FJ, Guy RK. Global phenotypic screening for antimalarials. Chemistry & Biology. 19: 116-29. PMID 22284359 DOI: 10.1016/j.chembiol.2012.01.004  1
2012 Guo J, Guiguemde AW, Bentura-Marciano A, Clark J, Haynes RK, Chan WC, Wong HN, Hunt NH, Guy RK, Golenser J. Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Antimicrobial Agents and Chemotherapy. 56: 163-73. PMID 22006004 DOI: 10.1128/AAC.05006-11  1
2011 Lack NA, Axerio-Cilies P, Tavassoli P, Han FQ, Chan KH, Feau C, LeBlanc E, Guns ET, Guy RK, Rennie PS, Cherkasov A. Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. Journal of Medicinal Chemistry. 54: 8563-73. PMID 22047606 DOI: 10.1021/jm201098n  1
2011 Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Optimization of propafenone analogues as antimalarial leads. Journal of Medicinal Chemistry. 54: 7477-85. PMID 21955244 DOI: 10.1021/jm2005546  1
2011 Hwang JY, Kawasuji T, Lowes DJ, Clark JA, Connelly MC, Zhu F, Guiguemde WA, Sigal MS, Wilson EB, Derisi JL, Guy RK. Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity. Journal of Medicinal Chemistry. 54: 7084-93. PMID 21910466 DOI: 10.1021/jm200636z  1
2011 Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, ... ... Guy RK, et al. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell. 20: 384-99. PMID 21907928 DOI: 10.1016/j.ccr.2011.08.013  1
2011 Sadana P, Hwang JY, Attia RR, Arnold LA, Neale G, Guy RK. Similarities and differences between two modes of antagonism of the thyroid hormone receptor. Acs Chemical Biology. 6: 1096-106. PMID 21815645 DOI: 10.1021/cb200092v  1
2011 Cui J, Chai SC, Shelat AA, Guy RK, Chen T. An automated approach to efficiently reformat a large collection of compounds. Current Chemical Genomics. 5: 42-7. PMID 21804905 DOI: 10.2174/1875397301105010042  0.6
2011 Féau C, Arnold LA, Kosinski A, Guy RK. Ligand competition binding assay for the androgen receptor. Methods in Molecular Biology (Clifton, N.J.). 776: 59-68. PMID 21796520 DOI: 10.1007/978-1-61779-243-4_4  1
2011 De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 11878-83. PMID 21730179 DOI: 10.1073/pnas.1105160108  1
2011 Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199  1
2011 Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. The Journal of Biological Chemistry. 286: 11895-908. PMID 21321127 DOI: 10.1074/jbc.M110.200436  1
2011 Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy RK, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Panetta JC, Boulos N, et al. Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 15-21. PMID 20947617 DOI: 10.1124/dmd.110.035915  0.4
2010 Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, ... ... Guy RK, et al. Evaluation of Diarylureas for Activity Against Plasmodium falciparum. Acs Medicinal Chemistry Letters. 1: 460-465. PMID 21243104 DOI: 10.1021/ml100083c  1
2010 Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK. Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & Medicinal Chemistry. 18: 8302-9. PMID 21051236 DOI: 10.1016/j.bmc.2010.09.073  1
2010 Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, ... ... Guy RK, et al. Chemical genetics of Plasmodium falciparum. Nature. 465: 311-5. PMID 20485428 DOI: 10.1038/nature09099  1
2010 Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. Journal of Medicinal Chemistry. 53: 3685-95. PMID 20361799 DOI: 10.1021/jm100057h  1
2010 Smithson DC, Lee J, Shelat AA, Phillips MA, Guy RK. Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. The Journal of Biological Chemistry. 285: 16771-81. PMID 20220141 DOI: 10.1074/jbc.M109.081588  1
2010 Zhang Y, Guiguemde WA, Sigal M, Zhu F, Connelly MC, Nwaka S, Guy RK. Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Bioorganic & Medicinal Chemistry. 18: 2756-66. PMID 20206533 DOI: 10.1016/j.bmc.2010.02.013  1
2010 Uddin MJ, Smithson DC, Brown KM, Crews BC, Connelly M, Zhu F, Marnett LJ, Guy RK. Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorganic & Medicinal Chemistry Letters. 20: 1787-91. PMID 20129783 DOI: 10.1016/j.bmcl.2010.01.009  1
2010 Smithson DC, Shelat AA, Baldwin J, Phillips MA, Guy RK. Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. Assay and Drug Development Technologies. 8: 175-85. PMID 20085486 DOI: 10.1089/adt.2009.0249  1
2010 Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. The Journal of Biological Chemistry. 285: 10786-96. PMID 20080970 DOI: 10.1074/jbc.M109.056747  1
2010 NICOLAOU KC, YANG Z, LIU J, NANTERMET PG, CLAIBORNE CF, RENAUD J, GUY RK, SHIBAYAMA K. ChemInform Abstract: Total Synthesis of Taxol. Part 3. Formation of Taxol′s ABC Ring Skeleton Cheminform. 26: no-no. DOI: 10.1002/chin.199527228  1
2010 NICOLAOU KC, LIU J, YANG Z, UENO H, SORENSEN EJ, CLAIBORNE CF, GUY RK, HWANG C, NAKADA M, NANTERMET PG. ChemInform Abstract: Total Synthesis of Taxol. Part 2. Construction of A and C Ring Intermediates and Initial Attempts to Construct the ABC Ring System Cheminform. 26: no-no. DOI: 10.1002/chin.199527227  1
2010 NICOLAOU KC, NANTERMET PG, UENO H, GUY RK, COULADOUROS EA, SORENSEN EJ. ChemInform Abstract: Total Synthesis of Taxol. Part 1. Retrosynthesis, Degradation, and Reconstitution. Cheminform. 26: no-no. DOI: 10.1002/chin.199527226  0.01
2010 NICOLAOU KC, COULADOUROS EA, NANTERMET PG, RENAUD J, GUY RK, WRASIDLO W. ChemInform Abstract: Synthesis of C-2 Taxol Analogues. Cheminform. 26: no-no. DOI: 10.1002/chin.199502148  1
2010 NICOLAOU KC, YANG Z, LIU JJ, UENO H, NANTERMET PG, GUY RK, CLAIBORNE CF, RENAUD J, COULADOUROS EA, PAULVANNAN K, SORENSEN EJ. ChemInform Abstract: Total synthesis of taxol. Cheminform. 25: no-no. DOI: 10.1002/chin.199426230  1
2010 NICOLAOU KC, NANTERMET PG, UENO H, GUY RK. ChemInform Abstract: Novel Chemistry of Taxol. Retrosynthetic and Synthetic Studies. Cheminform. 25: no-no. DOI: 10.1002/chin.199423201  1
2009 Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. Journal of Medicinal Chemistry. 52: 6489-93. PMID 19769357 DOI: 10.1021/jm900908p  0.48
2009 Margolis RN, Moore DD, Willson TM, Guy RK. Chemical approaches to nuclear receptors in metabolism. Science Signaling. 2: mr5. PMID 19654413 DOI: 10.1126/scisignal.282mr5  1
2009 Féau C, Arnold LA, Kosinski A, Zhu F, Connelly M, Guy RK. Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription. Acs Chemical Biology. 4: 834-43. PMID 19645433 DOI: 10.1021/cb900143a  1
2009 Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nature Chemical Biology. 5: 640-6. PMID 19633659 DOI: 10.1038/nchembio.192  1
2009 Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. Journal of Medicinal Chemistry. 52: 3892-901. PMID 19469546 DOI: 10.1021/jm9002704  1
2009 Mallari JP, Guiguemde WA, Guy RK. Antimalarial activity of thiosemicarbazones and purine derived nitriles. Bioorganic & Medicinal Chemistry Letters. 19: 3546-9. PMID 19447616 DOI: 10.1016/j.bmcl.2009.04.142  1
2009 Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Non-competitive androgen receptor inhibition in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 7233-8. PMID 19363158 DOI: 10.1073/pnas.0807282106  1
2009 Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry. 48: 1454-61. PMID 19183053 DOI: 10.1021/bi801874n  1
2009 Féau C, Arnold LA, Kosinski A, Guy RK. A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors. Journal of Biomolecular Screening. 14: 43-8. PMID 19171919 DOI: 10.1177/1087057108326662  1
2009 Shelat AA, Guy RK. A road less traveled by: exploring a decade of Ellman chemistry. Bioorganic & Medicinal Chemistry. 17: 1088-93. PMID 18343129 DOI: 10.1016/j.bmc.2008.02.087  1
2008 Arnold LA, Ranaivo P, Guy RK. Synthesis and characterization of BODIPY-labeled colchicine. Bioorganic & Medicinal Chemistry Letters. 18: 5867-70. PMID 18684625 DOI: 10.1016/j.bmcl.2008.07.068  1
2008 Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorganic & Medicinal Chemistry Letters. 18: 2883-5. PMID 18420405 DOI: 10.1016/j.bmcl.2008.03.083  1
2008 Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Partial acetylation of lysine residues improves intraprotein cross-linking. Analytical Chemistry. 80: 951-60. PMID 18201069 DOI: 10.1021/ac701636w  1
2008 Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. Journal of Medicinal Chemistry. 51: 545-52. PMID 18173229 DOI: 10.1021/jm070760l  1
2008 Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum (Journal of Medical Chemistry (2006) 49 (4540)) Journal of Medicinal Chemistry. 51: 699. DOI: 10.1021/jm701572a  1
2007 Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallographica. Section D, Biological Crystallography. 63: 1198-200. PMID 18007036 DOI: 10.1107/S0907444907045702  1
2007 Mills NL, Shelat AA, Guy RK. Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen. Journal of Biomolecular Screening. 12: 946-55. PMID 17942787 DOI: 10.1177/1087057107306128  1
2007 Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. Journal of Medicinal Chemistry. 50: 5727-34. PMID 17941623 DOI: 10.1021/jm0706867  1
2007 Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. Journal of Medicinal Chemistry. 50: 5269-80. PMID 17918822 DOI: 10.1021/jm070556y  1
2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 16074-9. PMID 17911242 DOI: 10.1073/pnas.0708036104  1
2007 Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Molecular Endocrinology (Baltimore, Md.). 21: 2919-28. PMID 17823305 DOI: 10.1210/me.2007-0174  1
2007 Shelat AA, Guy RK. Scaffold composition and biological relevance of screening libraries. Nature Chemical Biology. 3: 442-6. PMID 17637770 DOI: 10.1038/nchembio0807-442  1
2007 Inglese J, Shamu CE, Guy RK. Reporting data from high-throughput screening of small-molecule libraries. Nature Chemical Biology. 3: 438-41. PMID 17637769 DOI: 10.1038/nchembio0807-438  1
2007 Shelat AA, Guy RK. The interdependence between screening methods and screening libraries. Current Opinion in Chemical Biology. 11: 244-51. PMID 17524728 DOI: 10.1016/j.cbpa.2007.05.003  1
2007 Warhurst DC, Craig JC, Adagu IS, Guy RK, Madrid PB, Fivelman QL. Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. Biochemical Pharmacology. 73: 1910-26. PMID 17466277 DOI: 10.1016/j.bcp.2007.03.011  1
2007 Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Research. 67: 573-9. PMID 17234765 DOI: 10.1158/0008-5472.CAN-06-2726  1
2007 Fujii N, Shelat A, Hall RA, Guy RK. Design of a selective chemical probe for class I PDZ domains. Bioorganic & Medicinal Chemistry Letters. 17: 546-8. PMID 17074480 DOI: 10.1016/j.bmcl.2006.10.027  0.24
2007 Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorganic & Medicinal Chemistry Letters. 17: 549-52. PMID 17055267 DOI: 10.1016/j.bmcl.2006.10.006  0.56
2007 Arnold LA, Guy RK. Synthesis of Highly Substituted Dibenzo[b,f]azocines and Their Evaluation as Protein Kinase Inhibitors. Cheminform. 38. DOI: 10.1002/chin.200705167  0.01
2006 Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, ... ... Guy RK, et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 444: 61-6. PMID 17080083 DOI: 10.1038/nature05194  1
2006 Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL. Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. Chemistry & Biology. 13: 993-1000. PMID 16984889 DOI: 10.1016/j.chembiol.2006.07.009  1
2006 Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. Journal of Combinatorial Chemistry. 8: 784-90. PMID 16961415 DOI: 10.1021/cc050136z  1
2006 Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL. Searching for new antimalarial therapeutics amongst known drugs. Chemical Biology & Drug Design. 67: 409-16. PMID 16882315 DOI: 10.1111/j.1747-0285.2006.00391.x  1
2006 May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorganic & Medicinal Chemistry Letters. 16: 4913-6. PMID 16860557 DOI: 10.1016/j.bmcl.2006.06.050  1
2006 Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. Journal of Medicinal Chemistry. 49: 4535-43. PMID 16854059 DOI: 10.1021/jm0600951  1
2006 Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Science's Stke : Signal Transduction Knowledge Environment. 2006: pl3. PMID 16804159 DOI: 10.1126/stke.3412006pl3  1
2006 Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. Journal of Combinatorial Chemistry. 8: 315-25. PMID 16677000 DOI: 10.1021/cc050142v  1
2006 Mills NL, Daugherty MD, Frankel AD, Guy RK. An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction. Journal of the American Chemical Society. 128: 3496-7. PMID 16536504 DOI: 10.1021/ja0582051  1
2006 Anderson MO, Sherrill J, Madrid PB, Liou AP, Weisman JL, DeRisi JL, Guy RK. Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 14: 334-43. PMID 16216519 DOI: 10.1016/j.bmc.2005.08.017  1
2006 Nicolaou KC, Claiborne CF, Paulvannan K, H. D. Postema M, Guy RK. The Chemical Synthesis of C-Ring Aryl Taxoids Chemistry - a European Journal. 3: 399-409. DOI: 10.1002/chem.19970030311  1
2005 Feng BY, Shelat A, Doman TN, Guy RK, Shoichet BK. High-throughput assays for promiscuous inhibitors. Nature Chemical Biology. 1: 146-8. PMID 16408018 DOI: 10.1038/nchembio718  1
2005 Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. The Journal of Biological Chemistry. 280: 43048-55. PMID 16263725 DOI: 10.1074/jbc.M506693200  1
2005 Anderson MO, Shelat AA, Guy RK. A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin. The Journal of Organic Chemistry. 70: 4578-84. PMID 15932292 DOI: 10.1021/jo0503153  1
2005 Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 120: 343-55. PMID 15707893 DOI: 10.1016/j.cell.2005.01.024  1
2005 Madrid PB, Sherrill J, Liou AP, Weisman JL, Derisi JL, Guy RK. Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. Bioorganic & Medicinal Chemistry Letters. 15: 1015-8. PMID 15686903 DOI: 10.1016/j.bmcl.2004.12.037  1
2005 Moore JM, Guy RK. Coregulator interactions with the thyroid hormone receptor. Molecular & Cellular Proteomics : McP. 4: 475-82. PMID 15657066 DOI: 10.1074/mcp.R500001-MCP200  1
2005 Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorganic & Medicinal Chemistry Letters. 15: 121-3. PMID 15582423 DOI: 10.1016/j.bmcl.2004.10.023  1
2005 Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. The Journal of Biological Chemistry. 280: 8060-8. PMID 15563469 DOI: 10.1074/jbc.M407046200  1
2004 Arnold LA, Luo W, Guy RK. Synthesis of medium ring heterocycles using an intramolecular Heck reaction. Organic Letters. 6: 3005-7. PMID 15330669 DOI: 10.1021/ol0487884  1
2004 Madrid PB, Wilson NT, DeRisi JL, Guy RK. Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. Journal of Combinatorial Chemistry. 6: 437-42. PMID 15132606 DOI: 10.1021/cc0340473  1
2004 Geistlinger TR, McReynolds AC, Guy RK. Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Chemistry & Biology. 11: 273-81. PMID 15123288 DOI: 10.1016/j.chembiol.2004.01.016  1
2004 Moore JM, Galicia SJ, McReynolds AC, Nguyen NH, Scanlan TS, Guy RK. Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. The Journal of Biological Chemistry. 279: 27584-90. PMID 15100213 DOI: 10.1074/jbc.M403453200  1
2004 Evans WE, Guy RK. Gene expression as a drug discovery tool. Nature Genetics. 36: 214-5. PMID 14988717 DOI: 10.1038/ng0304-214  1
2004 Fujii N, Jacobsen RB, Wood NL, Schoeniger JS, Guy RK. A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D). Bioorganic & Medicinal Chemistry Letters. 14: 427-9. PMID 14698174 DOI: 10.1016/j.bmcl.2003.10.043  1
2004 Anderson MO, Moser J, Sherrill J, Guy RK. A convenient procedure for parallel ester hydrolysis Synlett. 2391-2393. DOI: 10.1055/s-2004-832828  1
2003 Geistlinger TR, Guy RK. Steroid receptor coactivator peptidomimetics. Methods in Enzymology. 364: 223-46. PMID 14631848 DOI: 10.1016/S0076-6879(03)64013-9  1
2003 Gochin M, Kiplin Guy R, Case MA. A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding. Angewandte Chemie (International Ed. in English). 42: 5325-8. PMID 14613166 DOI: 10.1002/anie.200352006  1
2003 Collins CJ, Schilling B, Young M, Dollinger G, Guy RK. Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides. Bioorganic & Medicinal Chemistry Letters. 13: 4023-6. PMID 14592499 DOI: 10.1016/j.bmcl.2003.08.053  1
2003 Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. A selective irreversible inhibitor targeting a PDZ protein interaction domain. Journal of the American Chemical Society. 125: 12074-5. PMID 14518976 DOI: 10.1021/ja035540l  1
2003 Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorganic & Medicinal Chemistry. 11: 4113-20. PMID 12927873 DOI: 10.1016/S0968-0896(03)00435-8  1
2003 Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. The Journal of Biological Chemistry. 278: 35079-85. PMID 12832418 DOI: 10.1074/jbc.M303098200  1
2003 Geistlinger TR, Guy RK. Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2. Journal of the American Chemical Society. 125: 6852-3. PMID 12783522 DOI: 10.1021/ja0348391  1
2003 Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 42: 2797-805. PMID 12627945 DOI: 10.1021/bi027061p  1
2002 Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjugate Chemistry. 13: 1093-9. PMID 12236791 DOI: 10.1021/bc0200226  1
2002 Novak KA, Fujii N, Guy RK. Investigation of the PDZ domain ligand binding site using chemically modified peptides. Bioorganic & Medicinal Chemistry Letters. 12: 2471-4. PMID 12161160  1
2001 Geistlinger TR, Guy RK. An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1. Journal of the American Chemical Society. 123: 1525-6. PMID 11456738 DOI: 10.1021/ja005549c  1
2000 Herradura PS, Pendola KA, Guy RK. Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols. Organic Letters. 2: 2019-22. PMID 10891219  1
2000 Guy RK. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proceedings of the National Academy of Sciences of the United States of America. 97: 7307-12. PMID 10860995 DOI: 10.1073/pnas.97.13.7307  1
1997 Dobrosotskaya I, Guy RK, James GL. MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. The Journal of Biological Chemistry. 272: 31589-97. PMID 9395497 DOI: 10.1074/jbc.272.50.31589  1
1996 Guy RK, Scott ZA, Sloboda RD, Nicolaou KC. Fluorescent taxoids Chemistry and Biology. 3: 1021-1031. PMID 9000007  1
1996 Nicolaou KC, Guy RK, Potier P. Taxoids: new weapons against cancer. Scientific American. 274: 94-8. PMID 8643952 DOI: 10.1038/scientificamerican0696-94  1
1995 Nicolaou KC, Liu J, Yang Z, Ueno H, Sorensen EJ, Claiborne CF, Guy RK, Hwang C, Nakada M, Nantermet PG. Total synthesis of Taxol. 2. construction of A and C ring intermediates and initial attempts to construct the ABC ring system. [Erratum to document cited in CA122:160984] Journal of the American Chemical Society. 117: 8690-8690. DOI: 10.1021/ja00138a035  0.04
1995 Nicolaou KC, Renaud J, Nantermet PG, Couladouros EA, Guy RK, Wrasidlo W. Chemical Synthesis and Biological Evaluation of C-2 Taxoids Journal of the American Chemical Society. 117: 2409-2420. DOI: 10.1021/ja00114a005  0.01
1995 Nicolaou KC, Yang Z, Liu JJ, Nantermet PG, Claiborne CF, Renaud J, Guy RK, Shibayama K. Total synthesis of Taxol. 3. Formation of Taxol's ABC ring skeleton Journal of the American Chemical Society. 117: 645-652. DOI: 10.1021/ja00107a008  1
1995 Nicolaou KC, Liu JJ, Yang Z, Ueno H, Sorensen EJ, Claiborne CF, Guy RK, Hwang CK, Nakada M, Nantermet PG. Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system Journal of the American Chemical Society. 117: 634-644. DOI: 10.1021/ja00107a007  1
1995 Nicolaou KC, Nantermet PG, Ueno H, Guy RK, Couladouros EA, Sorensen EJ. Total synthesis of Taxol. 1. Retrosynthesis, degradation, and reconstitution Journal of the American Chemical Society. 117: 624-633. DOI: 10.1021/ja00107a006  1
1994 Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou KC. Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chemistry & Biology. 1: 107-12. PMID 9383378 DOI: 10.1016/1074-5521(94)90048-5  1
1994 Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K. Total synthesis of taxol. Nature. 367: 630-4. PMID 7906395 DOI: 10.1038/367630a0  1
1994 Nicolaou KC, Nantermet PG, Ueno H, Guy RK. Novel chemistry of taxol. Retrosynthetic and synthetic studies Journal of the Chemical Society, Chemical Communications. 295-296. DOI: 10.1039/C39940000295  1
1994 Nicolaou KC, Couladouros EA, Nantermet PG, Renaud J, Guy RK, Wrasidlo W. Synthesis of C-2 Taxol Analogues Angewandte Chemie International Edition in English. 33: 1581-1583. DOI: 10.1002/anie.199415811  0.01
1994 Nicolaou KC, Dai W, Guy RK. Chemistry and Biology of Taxol Angewandte Chemie International Edition in English. 33: 15-44. DOI: 10.1002/anie.199400151  0.01
1994 Nicolaou KC, Couladouros EA, Nantermet PG, Renaud J, Guy RK, Wrasidlo W. Synthese von C-2-analogen Taxolen Angewandte Chemie. 106: 1669-1671. DOI: 10.1002/ange.19941061516  0.01
1994 Nicolaou KC, Dai W, Guy RK. Chemie und Biologie von Taxol Angewandte Chemie. 106: 38-69. DOI: 10.1002/ange.19941060105  0.08
1992 Guy RK, DiPietro RA. A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols Synthetic Communications. 22: 687-692. DOI: 10.1080/00397919208019270  1
1992 Nicolaou KC, Liu JJ, Hwang CK, Dai WM, Guy RK. Synthesis of a fully functionalized CD ring system of taxol Journal of the Chemical Society, Chemical Communications. 1118-1120. DOI: 10.1039/C39920001118  1
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