| Year |
Citation |
Score |
| 2020 |
Eagon S, Hammill JT, Sigal MS, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice A, Falade M, ... ... Guy RK, et al. Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. Journal of Medicinal Chemistry. PMID 32945666 DOI: 10.1021/Acs.Jmedchem.0C01152 |
0.799 |
|
| 2020 |
Slavish PJ, Chi L, Yun MK, Tsurkan L, Martinez NE, Jonchere B, Chai SC, Connelly M, Waddell MB, Das S, Neale G, Li Z, Shadrick WR, Olsen RR, Freeman KW, ... ... Guy RK, et al. Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer. Cancer Research. PMID 32651255 DOI: 10.1158/0008-5472.Can-19-3934 |
0.583 |
|
| 2019 |
Kim HS, Hammill JT, Scott DC, Chen Y, Min J, Rector J, Singh B, Schulman BA, Guy RK. Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Journal of Medicinal Chemistry. PMID 31465221 DOI: 10.1021/Acs.Jmedchem.9B00410 |
0.798 |
|
| 2019 |
Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein D, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. Acs Chemical Biology. PMID 31251562 DOI: 10.1021/acschembio.9b00488 |
0.486 |
|
| 2019 |
Drenberg CD, Shelat A, Dang J, Cotton A, Orwick SJ, Li M, Jeon JY, Fu Q, Buelow DR, Pioso M, Hu S, Inaba H, Ribeiro RC, Rubnitz JE, Gruber TA, ... Guy RK, et al. A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML. Nature Communications. 10: 2189. PMID 31097698 DOI: 10.1038/S41467-019-09917-0 |
0.525 |
|
| 2018 |
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29871975 DOI: 10.1042/Bsr20180231_Cor |
0.715 |
|
| 2018 |
Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547696 DOI: 10.1021/Acs.Jmedchem.7B01277 |
0.798 |
|
| 2018 |
Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547693 DOI: 10.1021/Acs.Jmedchem.7B01282 |
0.799 |
|
| 2018 |
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29472314 DOI: 10.1042/Bsr20180231 |
0.75 |
|
| 2018 |
Nimmervoll B, Boulos N, Bianski BM, Dapper J, DeCuypere M, Shelat AA, Terranova S, Terhune HE, Gajjar A, Patel YT, Freeman BB, Onar-Thomas A, Stewart CF, Roussel MF, Guy RK, et al. Establishing A Preclinical Multidisciplinary Board for Brain Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29301833 DOI: 10.1158/1078-0432.Ccr-17-2168 |
0.773 |
|
| 2017 |
Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, et al. Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Plos Neglected Tropical Diseases. 11: e0006157. PMID 29287089 DOI: 10.1371/Journal.Pntd.0006157 |
0.814 |
|
| 2017 |
Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein DB, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. Acs Chemical Biology. PMID 28787124 DOI: 10.1021/Acschembio.7B00527 |
0.547 |
|
| 2017 |
Yang J, Milasta S, Hu D, AlTahan A, Interiano R, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani A, Wang R, Wang Y, Ong SS, ... ... Guy RK, et al. Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Research. PMID 28684529 DOI: 10.1158/0008-5472.Can-16-0826 |
0.517 |
|
| 2017 |
Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, ... ... Guy RK, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature Chemical Biology. PMID 28581483 DOI: 10.1038/Nchembio.2386 |
0.785 |
|
| 2017 |
Jarusiewicz JA, Jeon JY, Connelly MC, Chen Y, Yang L, Baker SD, Guy RK. Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. Acs Omega. 2: 1985-2009. PMID 28580438 DOI: 10.1021/acsomega.7b00144 |
0.789 |
|
| 2017 |
Bharatham N, Finch KE, Min J, Mayasundari A, Dyer MA, Guy RK, Bashford D. Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx. Journal of Molecular Graphics & Modelling. 74: 54-60. PMID 28351017 DOI: 10.1016/j.jmgm.2017.02.014 |
0.7 |
|
| 2017 |
Kim HS, Hammill JT, Guy RK. Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). Journal of Medicinal Chemistry. PMID 28296396 DOI: 10.1021/Acs.Jmedchem.7B00299 |
0.724 |
|
| 2017 |
Verras A, Waller CL, Gedeck P, Green D, Kogej T, Raichurkar AV, Panda M, Shelat AA, Clark JA, Guy RK, Papadatos G, Burrows JN. Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition. Journal of Chemical Information and Modeling. PMID 28257198 DOI: 10.1021/Acs.Jcim.6B00572 |
0.558 |
|
| 2016 |
Mathew B, Hobrath JV, Ross L, Connelly MC, Lofton H, Rajagopalan M, Guy RK, Reynolds RC. Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. Plos One. 11: e0164100. PMID 27768711 DOI: 10.1371/journal.pone.0164100 |
0.308 |
|
| 2016 |
Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Guy RK, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/Journal.Ppat.1005763 |
0.547 |
|
| 2016 |
Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, ... ... Guy RK, et al. Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum. Malaria Journal. 15: 270. PMID 27165106 DOI: 10.1186/S12936-016-1313-7 |
0.791 |
|
| 2016 |
Drenberg CD, Buaboonnam J, Orwick SJ, Hu S, Li L, Fan Y, Shelat AA, Guy RK, Rubnitz J, Baker SD. Evaluation of artemisinins for the treatment of acute myeloid leukemia. Cancer Chemotherapy and Pharmacology. PMID 27125973 DOI: 10.1007/S00280-016-3038-2 |
0.469 |
|
| 2016 |
Nimmervoll B, Patel Y, Bianski B, DeCuypere M, Shelat A, Stewart C, Merchant T, Guy RK, Gilbertson R. PCM-22A NEW APPROACH OF PRECLINICAL TESTING OF CHEMOTHERAPIES - AN EXAMPLE OF BRAIN TUMOUR THERAPY Neuro-Oncology. 18: iii144-iii144. DOI: 10.1093/Neuonc/Now080.22 |
0.514 |
|
| 2015 |
Min J, Guo K, Suryadevara PK, Zhu F, Holbrook G, Chen Y, Feau C, Young BM, Lemoff A, Connelly MC, Kastan MB, Guy RK. Optimization of a Novel Series of Ataxia-Telangiectasia Mutated (ATM) Kinase Inhibitors as Potential Radiosensitizing Agents. Journal of Medicinal Chemistry. PMID 26632965 DOI: 10.1021/Acs.Jmedchem.5B01092 |
0.789 |
|
| 2015 |
Porth I, Klápště J, McKown AD, La Mantia J, Guy RD, Ingvarsson PK, Hamelin R, Mansfield SD, Ehlting J, Douglas CJ, El-Kassaby YA. Evolutionary Quantitative Genomics of Populus trichocarpa. Plos One. 10: e0142864. PMID 26599762 DOI: 10.1371/Journal.Pone.0142864 |
0.499 |
|
| 2015 |
Pritchard EM, Dyer MA, Guy RK. Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma. Mini Reviews in Medicinal Chemistry. PMID 26202204 DOI: 10.2174/1389557515666150722100610 |
0.726 |
|
| 2015 |
Ortiz D, Guiguemde WA, Johnson A, Elya C, Anderson J, Clark J, Connelly M, Yang L, Min J, Sato Y, Guy RK, Landfear SM. Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds. Plos One. 10: e0123598. PMID 25894322 DOI: 10.1371/journal.pone.0123598 |
0.301 |
|
| 2015 |
Geraldes A, Hefer CA, Capron A, Kolosova N, Martinez-Nuñez F, Soolanayakanahally RY, Stanton B, Guy RD, Mansfield SD, Douglas CJ, Cronk QC. Recent Y chromosome divergence despite ancient origin of dioecy in poplars (Populus). Molecular Ecology. 24: 3243-56. PMID 25728270 DOI: 10.1111/Mec.13126 |
0.479 |
|
| 2015 |
Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC. Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen. Antimicrobial Agents and Chemotherapy. 59: 1389-97. PMID 25512421 DOI: 10.1128/AAC.01930-13 |
0.806 |
|
| 2014 |
Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, ... ... Guy RK, et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proceedings of the National Academy of Sciences of the United States of America. 111: E5455-62. PMID 25453091 DOI: 10.1073/Pnas.1414221111 |
0.665 |
|
| 2014 |
Barnett DS, Guy RK. Antimalarials in Development in 2014. Chemical Reviews. PMID 25340626 DOI: 10.1021/cr500543f |
0.522 |
|
| 2014 |
Geraldes A, Farzaneh N, Grassa CJ, McKown AD, Guy RD, Mansfield SD, Douglas CJ, Cronk QC. Landscape genomics of Populus trichocarpa: the role of hybridization, limited gene flow, and natural selection in shaping patterns of population structure. Evolution; International Journal of Organic Evolution. 68: 3260-80. PMID 25065449 DOI: 10.1111/Evo.12497 |
0.499 |
|
| 2014 |
Vara BA, Mayasundari A, Tellis JC, Danneman MW, Arredondo V, Davis TA, Min J, Finch K, Guy RK, Johnston JN. Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition. The Journal of Organic Chemistry. 79: 6913-38. PMID 25017623 DOI: 10.1021/Jo501003R |
0.673 |
|
| 2014 |
Pritchard EM, Stewart E, Zhu F, Bradley C, Griffiths L, Yang L, Suryadevara PK, Zhang J, Freeman BB, Guy RK, Dyer MA. Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma. Pharmaceutical Research. 31: 3060-72. PMID 24906597 DOI: 10.1007/S11095-014-1399-Y |
0.762 |
|
| 2014 |
McKown AD, Klápšt? J, Guy RD, Geraldes A, Porth I, Hannemann J, Friedmann M, Muchero W, Tuskan GA, Ehlting J, Cronk QC, El-Kassaby YA, Mansfield SD, Douglas CJ. Genome-wide association implicates numerous genes underlying ecological trait variation in natural populations of Populus trichocarpa. The New Phytologist. 203: 535-53. PMID 24750093 DOI: 10.1111/Nph.12815 |
0.488 |
|
| 2014 |
Morfouace M, Shelat A, Jacus M, Freeman BB, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, ... Guy RK, et al. Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Cancer Cell. 25: 516-29. PMID 24684846 DOI: 10.1016/J.Ccr.2014.02.009 |
0.536 |
|
| 2014 |
Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, ... Guy RK, et al. UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. Journal of Natural Products. 77: 902-9. PMID 24617915 DOI: 10.1021/Np4009706 |
0.797 |
|
| 2014 |
McKown AD, Guy RD, Klápšt? J, Geraldes A, Friedmann M, Cronk QC, El-Kassaby YA, Mansfield SD, Douglas CJ. Geographical and environmental gradients shape phenotypic trait variation and genetic structure in Populus trichocarpa. The New Phytologist. 201: 1263-76. PMID 24491114 DOI: 10.1111/Nph.12601 |
0.485 |
|
| 2014 |
Guo K, Shelat AA, Guy RK, Kastan MB. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. Journal of Biomolecular Screening. 19: 538-46. PMID 24464432 DOI: 10.1177/1087057113520325 |
0.538 |
|
| 2014 |
Porth I, Klápste J, McKown AD, La Mantia J, Hamelin RC, Skyba O, Unda F, Friedmann MC, Cronk QC, Ehlting J, Guy RD, Mansfield SD, El-Kassaby YA, Douglas CJ. Extensive functional pleiotropy of REVOLUTA substantiated through forward genetics. Plant Physiology. 164: 548-54. PMID 24309192 DOI: 10.1104/Pp.113.228783 |
0.503 |
|
| 2014 |
Barchet GL, Dauwe R, Guy RD, Schroeder WR, Soolanayakanahally RY, Campbell MM, Mansfield SD. Investigating the drought-stress response of hybrid poplar genotypes by metabolite profiling. Tree Physiology. 34: 1203-19. PMID 24178982 DOI: 10.1093/treephys/tpt080 |
0.502 |
|
| 2014 |
Singh H, Shelat AA, Singh A, Boulos N, Williams RT, Guy RK. A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia. Journal of Biomolecular Screening. 19: 158-67. PMID 23989453 DOI: 10.1177/1087057113501081 |
0.543 |
|
| 2014 |
Koss C, Nance S, Connelly M, Ma J, Shelat A, Cotton A, An Q, Cheng C, Metzger ML, Jeha S, Rubnitz JE, Downing JR, Guy RK, Gruber TA. Targeted Inhibition of the MLL Transcriptional Complex By Proteosome Inhibitors Elicits a High Response Rate in Relapsed/Refractory MLL Rearranged Leukemia Blood. 124: 972-972. DOI: 10.1182/Blood.V124.21.972.972 |
0.568 |
|
| 2013 |
Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. Plos One. 8: e82962. PMID 24391728 DOI: 10.1371/Journal.Pone.0082962 |
0.534 |
|
| 2013 |
La Mantia J, Klápšt? J, El-Kassaby YA, Azam S, Guy RD, Douglas CJ, Mansfield SD, Hamelin R. Association analysis identifies Melampsora ×columbiana poplar leaf rust resistance SNPs. Plos One. 8: e78423. PMID 24236018 DOI: 10.1371/Journal.Pone.0078423 |
0.514 |
|
| 2013 |
Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry. 56: 2850-60. PMID 23484493 DOI: 10.1021/jm301687p |
0.787 |
|
| 2013 |
Hwang JY, Attia RR, Carrillo AK, Connelly MC, Guy RK. Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Bioorganic & Medicinal Chemistry Letters. 23: 1891-5. PMID 23414840 DOI: 10.1016/j.bmcl.2012.12.055 |
0.8 |
|
| 2013 |
Zhang L, Fourches D, Sedykh A, Zhu H, Golbraikh A, Ekins S, Clark J, Connelly MC, Sigal M, Hodges D, Guiguemde A, Guy RK, Tropsha A. Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening. Journal of Chemical Information and Modeling. 53: 475-92. PMID 23252936 DOI: 10.1021/Ci300421N |
0.803 |
|
| 2012 |
Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, ... ... Guy RK, et al. Lead optimization of antimalarial propafenone analogues. Journal of Medicinal Chemistry. 55: 6087-93. PMID 22708838 DOI: 10.1021/Jm300286A |
0.805 |
|
| 2012 |
Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. Plos One. 7: e37518. PMID 22675482 DOI: 10.1371/journal.pone.0037518 |
0.805 |
|
| 2012 |
Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. Journal of Medicinal Chemistry. 55: 4640-51. PMID 22563729 DOI: 10.1021/Jm300460C |
0.781 |
|
| 2012 |
Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, ... Guy RK, et al. Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. Journal of Medicinal Chemistry. 55: 4205-19. PMID 22435599 DOI: 10.1021/jm201642z |
0.445 |
|
| 2012 |
Hwang JY, Attia RR, Zhu F, Yang L, Lemoff A, Jeffries C, Connelly MC, Guy RK. Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. Journal of Medicinal Chemistry. 55: 2301-10. PMID 22324546 DOI: 10.1021/Jm201546M |
0.811 |
|
| 2012 |
Guiguemde WA, Shelat AA, Garcia-Bustos JF, Diagana TT, Gamo FJ, Guy RK. Global phenotypic screening for antimalarials. Chemistry & Biology. 19: 116-29. PMID 22284359 DOI: 10.1016/J.Chembiol.2012.01.004 |
0.593 |
|
| 2012 |
Guo J, Guiguemde AW, Bentura-Marciano A, Clark J, Haynes RK, Chan WC, Wong HN, Hunt NH, Guy RK, Golenser J. Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Antimicrobial Agents and Chemotherapy. 56: 163-73. PMID 22006004 DOI: 10.1128/AAC.05006-11 |
0.78 |
|
| 2011 |
Lack NA, Axerio-Cilies P, Tavassoli P, Han FQ, Chan KH, Feau C, LeBlanc E, Guns ET, Guy RK, Rennie PS, Cherkasov A. Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. Journal of Medicinal Chemistry. 54: 8563-73. PMID 22047606 DOI: 10.1021/Jm201098N |
0.818 |
|
| 2011 |
Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Optimization of propafenone analogues as antimalarial leads. Journal of Medicinal Chemistry. 54: 7477-85. PMID 21955244 DOI: 10.1021/Jm2005546 |
0.789 |
|
| 2011 |
Hwang JY, Kawasuji T, Lowes DJ, Clark JA, Connelly MC, Zhu F, Guiguemde WA, Sigal MS, Wilson EB, Derisi JL, Guy RK. Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity. Journal of Medicinal Chemistry. 54: 7084-93. PMID 21910466 DOI: 10.1021/jm200636z |
0.787 |
|
| 2011 |
Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, ... ... Guy RK, et al. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell. 20: 384-99. PMID 21907928 DOI: 10.1016/J.Ccr.2011.08.013 |
0.562 |
|
| 2011 |
Sadana P, Hwang JY, Attia RR, Arnold LA, Neale G, Guy RK. Similarities and differences between two modes of antagonism of the thyroid hormone receptor. Acs Chemical Biology. 6: 1096-106. PMID 21815645 DOI: 10.1021/cb200092v |
0.792 |
|
| 2011 |
Cui J, Chai SC, Shelat AA, Guy RK, Chen T. An automated approach to efficiently reformat a large collection of compounds. Current Chemical Genomics. 5: 42-7. PMID 21804905 DOI: 10.2174/1875397301105010042 |
0.559 |
|
| 2011 |
Féau C, Arnold LA, Kosinski A, Guy RK. Ligand competition binding assay for the androgen receptor. Methods in Molecular Biology (Clifton, N.J.). 776: 59-68. PMID 21796520 DOI: 10.1007/978-1-61779-243-4_4 |
0.8 |
|
| 2011 |
De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 11878-83. PMID 21730179 DOI: 10.1073/Pnas.1105160108 |
0.794 |
|
| 2011 |
Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199 |
0.69 |
|
| 2011 |
Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. The Journal of Biological Chemistry. 286: 11895-908. PMID 21321127 DOI: 10.1074/jbc.M110.200436 |
0.808 |
|
| 2011 |
Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy RK, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Panetta JC, Boulos N, et al. Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 15-21. PMID 20947617 DOI: 10.1124/Dmd.110.035915 |
0.71 |
|
| 2011 |
Atkinson JM, Shelat AA, Kranenburg TA, Carcaboso AM, Arnold A, Wright KD, Johnson RA, Poppleton H, Mohankumar KM, Gibson P, Phoenix TN, Zhu L, Tong Y, Eden C, Gajjar A, ... ... Guy RK, et al. Abstract 4759: Integrated in vitro and in vivo screening of tumor and normal neural stem cells identifies potential new treatments of ependymoma Cancer Research. 71: 4759-4759. DOI: 10.1158/1538-7445.Am2011-4759 |
0.619 |
|
| 2010 |
Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, ... ... Guy RK, et al. Evaluation of Diarylureas for Activity Against Plasmodium falciparum. Acs Medicinal Chemistry Letters. 1: 460-465. PMID 21243104 DOI: 10.1021/Ml100083C |
0.71 |
|
| 2010 |
Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK. Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & Medicinal Chemistry. 18: 8302-9. PMID 21051236 DOI: 10.1016/J.Bmc.2010.09.073 |
0.755 |
|
| 2010 |
Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-DÃaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, ... ... Guy RK, et al. Chemical genetics of Plasmodium falciparum. Nature. 465: 311-5. PMID 20485428 DOI: 10.1038/Nature09099 |
0.807 |
|
| 2010 |
Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. Journal of Medicinal Chemistry. 53: 3685-95. PMID 20361799 DOI: 10.1021/Jm100057H |
0.746 |
|
| 2010 |
Smithson DC, Lee J, Shelat AA, Phillips MA, Guy RK. Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. The Journal of Biological Chemistry. 285: 16771-81. PMID 20220141 DOI: 10.1074/Jbc.M109.081588 |
0.809 |
|
| 2010 |
Zhang Y, Guiguemde WA, Sigal M, Zhu F, Connelly MC, Nwaka S, Guy RK. Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Bioorganic & Medicinal Chemistry. 18: 2756-66. PMID 20206533 DOI: 10.1016/j.bmc.2010.02.013 |
0.51 |
|
| 2010 |
Uddin MJ, Smithson DC, Brown KM, Crews BC, Connelly M, Zhu F, Marnett LJ, Guy RK. Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorganic & Medicinal Chemistry Letters. 20: 1787-91. PMID 20129783 DOI: 10.1016/J.Bmcl.2010.01.009 |
0.765 |
|
| 2010 |
Smithson DC, Shelat AA, Baldwin J, Phillips MA, Guy RK. Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. Assay and Drug Development Technologies. 8: 175-85. PMID 20085486 DOI: 10.1089/Adt.2009.0249 |
0.787 |
|
| 2010 |
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. The Journal of Biological Chemistry. 285: 10786-96. PMID 20080970 DOI: 10.1074/Jbc.M109.056747 |
0.79 |
|
| 2010 |
NICOLAOU KC, YANG Z, LIU JJ, UENO H, NANTERMET PG, GUY RK, CLAIBORNE CF, RENAUD J, COULADOUROS EA, PAULVANNAN K, SORENSEN EJ. ChemInform Abstract: Total synthesis of taxol. Cheminform. 25: no-no. DOI: 10.1002/chin.199426230 |
0.502 |
|
| 2010 |
NICOLAOU KC, NANTERMET PG, UENO H, GUY RK. ChemInform Abstract: Novel Chemistry of Taxol. Retrosynthetic and Synthetic Studies. Cheminform. 25: no-no. DOI: 10.1002/chin.199423201 |
0.348 |
|
| 2009 |
Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. Journal of Medicinal Chemistry. 52: 6489-93. PMID 19769357 DOI: 10.1021/Jm900908P |
0.806 |
|
| 2009 |
Margolis RN, Moore DD, Willson TM, Guy RK. Chemical approaches to nuclear receptors in metabolism. Science Signaling. 2: mr5. PMID 19654413 DOI: 10.1126/Scisignal.282Mr5 |
0.329 |
|
| 2009 |
Féau C, Arnold LA, Kosinski A, Zhu F, Connelly M, Guy RK. Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription. Acs Chemical Biology. 4: 834-43. PMID 19645433 DOI: 10.1021/cb900143a |
0.803 |
|
| 2009 |
Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. Journal of Medicinal Chemistry. 52: 3892-901. PMID 19469546 DOI: 10.1021/Jm9002704 |
0.674 |
|
| 2009 |
Mallari JP, Guiguemde WA, Guy RK. Antimalarial activity of thiosemicarbazones and purine derived nitriles. Bioorganic & Medicinal Chemistry Letters. 19: 3546-9. PMID 19447616 DOI: 10.1016/J.Bmcl.2009.04.142 |
0.773 |
|
| 2009 |
Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Non-competitive androgen receptor inhibition in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 7233-8. PMID 19363158 DOI: 10.1073/Pnas.0807282106 |
0.81 |
|
| 2009 |
Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry. 48: 1454-61. PMID 19183053 DOI: 10.1021/Bi801874N |
0.755 |
|
| 2009 |
Féau C, Arnold LA, Kosinski A, Guy RK. A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors. Journal of Biomolecular Screening. 14: 43-8. PMID 19171919 DOI: 10.1177/1087057108326662 |
0.791 |
|
| 2009 |
Shelat AA, Guy RK. A road less traveled by: exploring a decade of Ellman chemistry. Bioorganic & Medicinal Chemistry. 17: 1088-93. PMID 18343129 DOI: 10.1016/J.Bmc.2008.02.087 |
0.541 |
|
| 2009 |
Atkinson JM, Shelat A, Johnson R, Wright K, Poppleton H, Mohankumar KM, Feau C, Arnold A, White E, Kranenburg T, Guy RK, Gilbertson RJ. Abstract A52: An interspecies genomics based high‐throughput screen for novel treatments of ependymoma Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A52 |
0.62 |
|
| 2008 |
Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorganic & Medicinal Chemistry Letters. 18: 2883-5. PMID 18420405 DOI: 10.1016/J.Bmcl.2008.03.083 |
0.794 |
|
| 2008 |
Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Partial acetylation of lysine residues improves intraprotein cross-linking. Analytical Chemistry. 80: 951-60. PMID 18201069 DOI: 10.1021/Ac701636W |
0.697 |
|
| 2008 |
Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. Journal of Medicinal Chemistry. 51: 545-52. PMID 18173229 DOI: 10.1021/Jm070760L |
0.794 |
|
| 2008 |
Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum (Journal of Medical Chemistry (2006) 49 (4540)) Journal of Medicinal Chemistry. 51: 699. DOI: 10.1021/jm701572a |
0.696 |
|
| 2007 |
Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallographica. Section D, Biological Crystallography. 63: 1198-200. PMID 18007036 DOI: 10.1107/S0907444907045702 |
0.632 |
|
| 2007 |
Mills NL, Shelat AA, Guy RK. Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen. Journal of Biomolecular Screening. 12: 946-55. PMID 17942787 DOI: 10.1177/1087057107306128 |
0.56 |
|
| 2007 |
Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. Journal of Medicinal Chemistry. 50: 5269-80. PMID 17918822 DOI: 10.1021/jm070556y |
0.671 |
|
| 2007 |
Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 16074-9. PMID 17911242 DOI: 10.1073/Pnas.0708036104 |
0.74 |
|
| 2007 |
Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Molecular Endocrinology (Baltimore, Md.). 21: 2919-28. PMID 17823305 DOI: 10.1210/Me.2007-0174 |
0.655 |
|
| 2007 |
Shelat AA, Guy RK. Scaffold composition and biological relevance of screening libraries. Nature Chemical Biology. 3: 442-6. PMID 17637770 DOI: 10.1038/Nchembio0807-442 |
0.526 |
|
| 2007 |
Shelat AA, Guy RK. The interdependence between screening methods and screening libraries. Current Opinion in Chemical Biology. 11: 244-51. PMID 17524728 DOI: 10.1016/J.Cbpa.2007.05.003 |
0.541 |
|
| 2007 |
Warhurst DC, Craig JC, Adagu IS, Guy RK, Madrid PB, Fivelman QL. Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. Biochemical Pharmacology. 73: 1910-26. PMID 17466277 DOI: 10.1016/J.Bcp.2007.03.011 |
0.651 |
|
| 2007 |
Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Research. 67: 573-9. PMID 17234765 DOI: 10.1158/0008-5472.Can-06-2726 |
0.671 |
|
| 2007 |
Fujii N, Shelat A, Hall RA, Guy RK. Design of a selective chemical probe for class I PDZ domains. Bioorganic & Medicinal Chemistry Letters. 17: 546-8. PMID 17074480 DOI: 10.1016/J.Bmcl.2006.10.027 |
0.72 |
|
| 2007 |
Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorganic & Medicinal Chemistry Letters. 17: 549-52. PMID 17055267 DOI: 10.1016/J.Bmcl.2006.10.006 |
0.738 |
|
| 2006 |
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, ... ... Guy RK, et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 444: 61-6. PMID 17080083 DOI: 10.1038/Nature05194 |
0.464 |
|
| 2006 |
Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL. Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. Chemistry & Biology. 13: 993-1000. PMID 16984889 DOI: 10.1016/J.Chembiol.2006.07.009 |
0.662 |
|
| 2006 |
Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. Journal of Combinatorial Chemistry. 8: 784-90. PMID 16961415 DOI: 10.1021/cc050136z |
0.582 |
|
| 2006 |
Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL. Searching for new antimalarial therapeutics amongst known drugs. Chemical Biology & Drug Design. 67: 409-16. PMID 16882315 DOI: 10.1111/j.1747-0285.2006.00391.x |
0.684 |
|
| 2006 |
May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorganic & Medicinal Chemistry Letters. 16: 4913-6. PMID 16860557 DOI: 10.1016/J.Bmcl.2006.06.050 |
0.763 |
|
| 2006 |
Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. Journal of Medicinal Chemistry. 49: 4535-43. PMID 16854059 DOI: 10.1021/Jm0600951 |
0.727 |
|
| 2006 |
Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Science's Stke : Signal Transduction Knowledge Environment. 2006: pl3. PMID 16804159 DOI: 10.1126/Stke.3412006Pl3 |
0.736 |
|
| 2006 |
Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. Journal of Combinatorial Chemistry. 8: 315-25. PMID 16677000 DOI: 10.1021/cc050142v |
0.643 |
|
| 2006 |
Anderson MO, Sherrill J, Madrid PB, Liou AP, Weisman JL, DeRisi JL, Guy RK. Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 14: 334-43. PMID 16216519 DOI: 10.1016/J.Bmc.2005.08.017 |
0.801 |
|
| 2006 |
Nicolaou KC, Claiborne CF, Paulvannan K, H. D. Postema M, Guy RK. The Chemical Synthesis of C-Ring Aryl Taxoids Chemistry - a European Journal. 3: 399-409. DOI: 10.1002/Chem.19970030311 |
0.34 |
|
| 2005 |
Feng BY, Shelat A, Doman TN, Guy RK, Shoichet BK. High-throughput assays for promiscuous inhibitors. Nature Chemical Biology. 1: 146-8. PMID 16408018 DOI: 10.1038/Nchembio718 |
0.574 |
|
| 2005 |
Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. The Journal of Biological Chemistry. 280: 43048-55. PMID 16263725 DOI: 10.1074/Jbc.M506693200 |
0.751 |
|
| 2005 |
Anderson MO, Shelat AA, Guy RK. A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin. The Journal of Organic Chemistry. 70: 4578-84. PMID 15932292 DOI: 10.1021/jo0503153 |
0.652 |
|
| 2005 |
Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 120: 343-55. PMID 15707893 DOI: 10.1016/J.Cell.2005.01.024 |
0.756 |
|
| 2005 |
Madrid PB, Sherrill J, Liou AP, Weisman JL, Derisi JL, Guy RK. Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. Bioorganic & Medicinal Chemistry Letters. 15: 1015-8. PMID 15686903 DOI: 10.1016/J.Bmcl.2004.12.037 |
0.713 |
|
| 2005 |
Moore JM, Guy RK. Coregulator interactions with the thyroid hormone receptor. Molecular & Cellular Proteomics : McP. 4: 475-82. PMID 15657066 DOI: 10.1074/mcp.R500001-MCP200 |
0.622 |
|
| 2005 |
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorganic & Medicinal Chemistry Letters. 15: 121-3. PMID 15582423 DOI: 10.1016/J.Bmcl.2004.10.023 |
0.798 |
|
| 2005 |
Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. The Journal of Biological Chemistry. 280: 8060-8. PMID 15563469 DOI: 10.1074/Jbc.M407046200 |
0.76 |
|
| 2004 |
Arnold LA, Luo W, Guy RK. Synthesis of medium ring heterocycles using an intramolecular Heck reaction. Organic Letters. 6: 3005-7. PMID 15330669 DOI: 10.1021/ol0487884 |
0.497 |
|
| 2004 |
Madrid PB, Wilson NT, DeRisi JL, Guy RK. Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. Journal of Combinatorial Chemistry. 6: 437-42. PMID 15132606 DOI: 10.1021/Cc0340473 |
0.743 |
|
| 2004 |
Geistlinger TR, McReynolds AC, Guy RK. Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Chemistry & Biology. 11: 273-81. PMID 15123288 DOI: 10.1016/J.Chembiol.2004.01.016 |
0.772 |
|
| 2004 |
Moore JM, Galicia SJ, McReynolds AC, Nguyen NH, Scanlan TS, Guy RK. Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. The Journal of Biological Chemistry. 279: 27584-90. PMID 15100213 DOI: 10.1074/Jbc.M403453200 |
0.795 |
|
| 2004 |
Fujii N, Jacobsen RB, Wood NL, Schoeniger JS, Guy RK. A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D). Bioorganic & Medicinal Chemistry Letters. 14: 427-9. PMID 14698174 DOI: 10.1016/J.Bmcl.2003.10.043 |
0.619 |
|
| 2004 |
Anderson MO, Moser J, Sherrill J, Guy RK. A convenient procedure for parallel ester hydrolysis Synlett. 2391-2393. DOI: 10.1055/s-2004-832828 |
0.461 |
|
| 2003 |
Geistlinger TR, Guy RK. Steroid receptor coactivator peptidomimetics. Methods in Enzymology. 364: 223-46. PMID 14631848 DOI: 10.1016/S0076-6879(03)64013-9 |
0.783 |
|
| 2003 |
Collins CJ, Schilling B, Young M, Dollinger G, Guy RK. Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides. Bioorganic & Medicinal Chemistry Letters. 13: 4023-6. PMID 14592499 DOI: 10.1016/J.Bmcl.2003.08.053 |
0.434 |
|
| 2003 |
Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. A selective irreversible inhibitor targeting a PDZ protein interaction domain. Journal of the American Chemical Society. 125: 12074-5. PMID 14518976 DOI: 10.1021/Ja035540L |
0.747 |
|
| 2003 |
Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorganic & Medicinal Chemistry. 11: 4113-20. PMID 12927873 DOI: 10.1016/S0968-0896(03)00435-8 |
0.572 |
|
| 2003 |
Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. The Journal of Biological Chemistry. 278: 35079-85. PMID 12832418 DOI: 10.1074/jbc.M303098200 |
0.493 |
|
| 2003 |
Geistlinger TR, Guy RK. Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2. Journal of the American Chemical Society. 125: 6852-3. PMID 12783522 DOI: 10.1021/Ja0348391 |
0.786 |
|
| 2003 |
Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 42: 2797-805. PMID 12627945 DOI: 10.1021/Bi027061P |
0.634 |
|
| 2002 |
Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjugate Chemistry. 13: 1093-9. PMID 12236791 DOI: 10.1021/Bc0200226 |
0.389 |
|
| 2002 |
Novak KA, Fujii N, Guy RK. Investigation of the PDZ domain ligand binding site using chemically modified peptides. Bioorganic & Medicinal Chemistry Letters. 12: 2471-4. PMID 12161160 DOI: 10.1016/S0960-894X(02)00345-1 |
0.634 |
|
| 2001 |
Geistlinger TR, Guy RK. An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1. Journal of the American Chemical Society. 123: 1525-6. PMID 11456738 DOI: 10.1021/ja005549c |
0.756 |
|
| 1996 |
Guy RK, Scott ZA, Sloboda RD, Nicolaou KC. Fluorescent taxoids Chemistry and Biology. 3: 1021-1031. PMID 9000007 |
0.339 |
|
| 1995 |
Nicolaou KC, Liu J, Yang Z, Ueno H, Sorensen EJ, Claiborne CF, Guy RK, Hwang C, Nakada M, Nantermet PG. Total synthesis of Taxol. 2. construction of A and C ring intermediates and initial attempts to construct the ABC ring system. [Erratum to document cited in CA122:160984] Journal of the American Chemical Society. 117: 8690-8690. DOI: 10.1021/Ja00138A035 |
0.55 |
|
| 1995 |
Nicolaou KC, Yang Z, Liu JJ, Nantermet PG, Claiborne CF, Renaud J, Guy RK, Shibayama K. Total synthesis of Taxol. 3. Formation of Taxol's ABC ring skeleton Journal of the American Chemical Society. 117: 645-652. DOI: 10.1021/Ja00107A008 |
0.396 |
|
| 1995 |
Nicolaou KC, Liu JJ, Yang Z, Ueno H, Sorensen EJ, Claiborne CF, Guy RK, Hwang CK, Nakada M, Nantermet PG. Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system Journal of the American Chemical Society. 117: 634-644. DOI: 10.1021/Ja00107A007 |
0.556 |
|
| 1995 |
Nicolaou KC, Nantermet PG, Ueno H, Guy RK, Couladouros EA, Sorensen EJ. Total synthesis of Taxol. 1. Retrosynthesis, degradation, and reconstitution Journal of the American Chemical Society. 117: 624-633. DOI: 10.1021/Ja00107A006 |
0.511 |
|
| 1994 |
Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou KC. Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chemistry & Biology. 1: 107-12. PMID 9383378 DOI: 10.1016/1074-5521(94)90048-5 |
0.339 |
|
| 1994 |
Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K. Total synthesis of taxol. Nature. 367: 630-4. PMID 7906395 DOI: 10.1038/367630A0 |
0.435 |
|
| 1994 |
Nicolaou KC, Nantermet PG, Ueno H, Guy RK. Novel chemistry of taxol. Retrosynthetic and synthetic studies Journal of the Chemical Society, Chemical Communications. 295-296. DOI: 10.1039/C39940000295 |
0.381 |
|
| 1994 |
Nicolaou KC, Dai W, Guy RK. Chemistry and Biology of Taxol Angewandte Chemie International Edition in English. 33: 15-44. DOI: 10.1002/Anie.199400151 |
0.401 |
|
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