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Victoria A. Ploplis - Publications

Affiliations: 
Chemistry and Biochemistry University of Notre Dame, Notre Dame, IN, United States 
Area:
fibrinolytic system
Website:
http://chemistry.nd.edu/faculty/detail/vploplis/

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ayinuola YA, Brito-Robinson T, Ayinuola O, Beck JE, Cruz-Topete D, Lee SW, Ploplis VA, Castellino FJ. Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence. The Journal of Biological Chemistry. PMID 33208461 DOI: 10.1074/jbc.RA120.016262  1
2020 Charles J, Castellino FJ, Ploplis VA. Past and Present Behçet's Disease Animal Models. Current Drug Targets. PMID 32682369 DOI: 10.2174/1389450121666200719010425  1
2020 Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, et al. Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacology & Translational Science. 3: 418-424. PMID 32566907 DOI: 10.1021/acsptsci.0c00001  1
2020 Qiu C, Yuan Y, Lee SW, Ploplis VA, Castellino FJ. A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen. The Biochemical Journal. PMID 32270857 DOI: 10.1042/BCJ20200197  1
2020 Carothers KE, Liang Z, Mayfield J, Donahue DL, Lee M, Boggess B, Ploplis VA, Castellino FJ, Lee SW. The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen USA300 through cleavage of the Staphylococcal SdrC protein. Journal of Bacteriology. PMID 32205460 DOI: 10.1128/JB.00008-20  1
2020 Russo B, Ayinuola YA, Singh D, Carothers K, Fischetti VA, FloresMireles A, Lee SW, Ploplis VA, Liang Z, Castellino FJ. The M-protein of strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene. Journal of Bacteriology. PMID 32123038 DOI: 10.1128/JB.00096-20  1
2019 Liang Z, Carothers K, Holmes A, Donahue D, Lee SW, Castellino FJ, Ploplis VA. Stable genetic integration of a red fluorescent protein in a virulent Group A strain. Access Microbiology. 1: e000062. PMID 32974562 DOI: 10.1099/acmi.0.000062  1
2019 Ploplis VA, Castellino FJ. Host Pathways of Hemostasis that Regulate Group A Streptococcus Pyogenes Pathogenicity. Current Drug Targets. PMID 31556853 DOI: 10.2174/1389450120666190926152914  1
2019 Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ. Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. Journal of Structural Biology. PMID 31301349 DOI: 10.1016/j.jsb.2019.07.005  1
2019 Walsh M, Moore EE, Moore H, Thomas S, Lune SV, Zimmer D, Dynako J, Hake D, Crowell Z, McCauley R, Larson EE, Miller M, Pohlman T, Achneck HE, Martin P, ... ... Ploplis VA, et al. Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review. Seminars in Thrombosis and Hemostasis. PMID 31108555 DOI: 10.1055/s-0039-1688497  1
2019 Ly D, Donahue D, Walker MJ, Ploplis VA, McArthur JD, Ranson M, Castellino FJ, Sanderson-Smith ML. Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection. PMID 31009808 DOI: 10.1016/j.micinf.2019.04.004  1
2019 Qiu C, Yuan Y, Liang Z, Lee SW, Ploplis VA, Castellino FJ. Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. Journal of Structural Biology. PMID 30880082 DOI: 10.1016/j.jsb.2019.03.003  1
2018 Qiu C, Yuan Y, Zajicek J, Liang Z, Balsara RD, Brito-Robionson T, Lee SW, Ploplis VA, Castellino FJ. Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization. Journal of Structural Biology. PMID 30071314 DOI: 10.1016/j.jsb.2018.07.017  1
2018 Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW. Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Skin Infection. Frontiers in Cellular and Infection Microbiology. 8: 211. PMID 30018884 DOI: 10.3389/fcimb.2018.00211  1
2018 Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ. Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia. Biomed Research International. 2018: 1878964. PMID 29977908 DOI: 10.1155/2018/1878964  1
2018 Liang Z, Stephens M, Ploplis VA, Lee SW, Castellino FJ. Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes. Genome Announcements. 6. PMID 29954901 DOI: 10.1128/genomeA.00592-18  1
2018 Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW. Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. The Journal of Antibiotics. PMID 29463889 DOI: 10.1038/s41429-018-0032-4  1
2017 Yuan Y, Zajicek J, Qiu C, Chandrahas V, Lee SW, Ploplis VA, Castellino FJ. Conformationally Organized Lysine Isosteres in Streptococcus Pyogenes M Protein Mediate Direct High-Affinity Binding to Human Plasminogen. The Journal of Biological Chemistry. PMID 28724633 DOI: 10.1074/jbc.M117.794198  1
2017 Bao YJ, Li Y, Liang Z, Agrahari G, Lee SW, Ploplis VA, Castellino FJ. Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers. Pathogens and Disease. PMID 28520869 DOI: 10.1093/femspd/ftx056  1
2017 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Scientific Reports. 7: 365. PMID 28336948 DOI: 10.1038/s41598-017-00418-y  1
2017 Glinton K, Beck J, Liang Z, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Variable Region in Streptococcal M-Proteins Provides Stable Binding with Host Fibrinogen for Plasminogen-Mediated Bacterial Invasion. The Journal of Biological Chemistry. PMID 28280245 DOI: 10.1074/jbc.M116.768937  1
2017 Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinsek A, Lantry J, Sheppard F, et al. Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between". Seminars in Thrombosis and Hemostasis. PMID 28219085 DOI: 10.1055/s-0036-1597900  0.72
2016 Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ. Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps. Scientific Reports. 6: 36644. PMID 27821851 DOI: 10.1038/srep36644  1
2016 Higashi DL, Biais N, Donahue DL, Mayfield JA, Tessier CR, Rodriguez K, Ashfeld BL, Luchetti J, Ploplis VA, Castellino FJ, Lee SW. Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis. Nature Microbiology. 1: 15004. PMID 27571972 DOI: 10.1038/nmicrobiol.2015.4  1
2016 Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ. Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potentials for evolutionary persistence. Microbiology (Reading, England). PMID 27329479 DOI: 10.1099/mic.0.000326  1
2016 Gupta KK, Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through toll-like receptor-4. Biochemical and Biophysical Research Communications. PMID 27317488 DOI: 10.1016/j.bbrc.2016.06.065  1
2016 Mamczak CN, Maloney M, Fritz B, Boyer B, Thomas S, Evans E, Ploplis VA, Castellino FJ, McCollester J, Walsh M. Thromboelastography in Orthopaedic Trauma Pelvic Fracture Resuscitation: A Descriptive Pilot Study. Journal of Orthopaedic Trauma. PMID 27206253 DOI: 10.1097/BOT.0000000000000537  1
2016 Yasui H, Donahue DL, Walsh M, Castellino FJ, Ploplis VA. Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00429.2015. PMID 27190065 DOI: 10.1152/ajplung.00429.2015  1
2016 Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ. Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. Journal of Bacteriology. PMID 27044623 DOI: 10.1128/JB.01019-15  1
2016 Walsh M, Fritz S, Hake D, Son M, Greve S, Jbara M, Chitta S, Fritz B, Miller A, Bader MK, McCollester J, Binz S, Liew-Spilge A, Thomas S, Crepinsek A, ... ... Ploplis V, et al. Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy. Current Drug Targets. PMID 26960340  1
2016 Agrahari G, Liang Z, Glinton K, Lee SW, Ploplis VA, Castellino FJ. Streptococcus pyogenes employs strain-dependent mechanisms of C3b inactivation to inhibit phagocytosis and killing of bacteria. The Journal of Biological Chemistry. PMID 26945067 DOI: 10.1074/jbc.M115.704221  0.36
2015 Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ. CovRS Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights on Virulence Determinants. Journal of Bacteriology. PMID 26216843 DOI: 10.1128/JB.00511-15  1
2015 Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ. Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein. The Journal of Biological Chemistry. 290: 18833-42. PMID 26070561 DOI: 10.1074/jbc.M115.655365  1
2015 Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. Plos One. 10: e0120728. PMID 25799354 DOI: 10.1371/journal.pone.0120728  1
2015 Genua M, D'Alessio S, Cibella J, Gandelli A, Sala E, Correale C, Spinelli A, Arena V, Malesci A, Rutella S, Ploplis VA, Vetrano S, Danese S. The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation. Gut. 64: 589-600. PMID 24848264 DOI: 10.1136/gutjnl-2013-305933  1
2014 Bao Y, Liang Z, Booyjzsen C, Mayfield JA, Li Y, Lee SW, Ploplis VA, Song H, Castellino FJ. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. Journal of Bacteriology. 196: 4089-102. PMID 25225265 DOI: 10.1128/JB.02131-14  1
2014 Mayfield JA, Liang Z, Agrahari G, Lee SW, Donahue DL, Ploplis VA, Castellino FJ. Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence. Plos One. 9: e100698. PMID 24968349 DOI: 10.1371/journal.pone.0100698  1
2014 Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ. Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain. The Journal of Biological Chemistry. 289: 21684-93. PMID 24962580 DOI: 10.1074/jbc.M114.570218  1
2014 Castellino FJ, Chapman MP, Donahue DL, Thomas S, Moore EE, Wohlauer MV, Fritz B, Yount R, Ploplis V, Davis P, Evans E, Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. The Journal of Trauma and Acute Care Surgery. 76: 1169-76. PMID 24747445 DOI: 10.1097/TA.0000000000000216  1
2014 Ploplis VA, Donahue DL, Sandoval-Cooper MJ, MorenoCaffaro M, Sheets P, Thomas SG, Walsh M, Castellino FJ. Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury. Journal of Neurotrauma. 31: 1672-5. PMID 24605991 DOI: 10.1089/neu.2013.3302  1
2014 Zhang Y, Mayfield JA, Ploplis VA, Castellino FJ. The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. Biochemical and Biophysical Research Communications. 444: 595-8. PMID 24486550 DOI: 10.1016/j.bbrc.2014.01.109  1
2014 Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. Journal of Neurotrauma. 31: 404-10. PMID 24040968 DOI: 10.1089/neu.2013.3089  1
2013 Agrahari G, Liang Z, Mayfield JA, Balsara RD, Ploplis VA, Castellino FJ. Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. The Journal of Biological Chemistry. 288: 27494-504. PMID 23928307 DOI: 10.1074/jbc.M113.494864  1
2013 Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. Plos Pathogens. 9: e1003469. PMID 23853591 DOI: 10.1371/journal.ppat.1003469  1
2013 Zhang Y, Liang Z, Glinton K, Ploplis VA, Castellino FJ. Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. Febs Letters. 587: 1304-9. PMID 23474243 DOI: 10.1016/j.febslet.2013.02.033  1
2013 Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ. A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. The Journal of Biological Chemistry. 288: 6561-73. PMID 23316057 DOI: 10.1074/jbc.M112.442657  1
2013 Davis PK, Musunuru H, Walsh M, Cassady R, Yount R, Losiniecki A, Moore EE, Wohlauer MV, Howard J, Ploplis VA, Castellino FJ, Thomas SG. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocritical Care. 18: 201-8. PMID 22847397 DOI: 10.1007/s12028-012-9745-6  1
2012 Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. Abnormal whole blood thrombi in humans with inherited platelet receptor defects. Plos One. 7: e52878. PMID 23300803 DOI: 10.1371/journal.pone.0052878  1
2012 Bhattacharya S, Ploplis VA, Castellino FJ. Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. Journal of Biomedicine & Biotechnology. 2012: 482096. PMID 23118509 DOI: 10.1155/2012/482096  1
2012 Zhang Y, Liang Z, Hsueh HT, Ploplis VA, Castellino FJ. Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. The Journal of Biological Chemistry. 287: 42093-103. PMID 23086939 DOI: 10.1074/jbc.M112.417808  1
2012 Narasaki R, Xu Z, Liang Z, Fung LC, Donahue D, Castellino FJ, Ploplis VA. The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. Journal of Thrombosis and Haemostasis : Jth. 10: 2618-21. PMID 23082983 DOI: 10.1111/jth.12032  1
2012 Davis PK, Musunuru H, Walsh M, Mitra R, Ploplis V, Castellino FJ. The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. Thrombosis and Haemostasis. 108: 586-8. PMID 22782135 DOI: 10.1160/TH12-04-0222  1
2012 Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. Journal of the American College of Surgeons. 214: 739-46. PMID 22520693 DOI: 10.1016/j.jamcollsurg.2012.01.050  1
2011 Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ. Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. The Journal of Extra-Corporeal Technology. 43: 162-7. PMID 22164456  1
2011 Vetrano S, Ploplis VA, Sala E, Sandoval-Cooper M, Donahue DL, Correale C, Arena V, Spinelli A, Repici A, Malesci A, Castellino FJ, Danese S. Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 108: 19830-5. PMID 22109555 DOI: 10.1073/pnas.1107140108  1
2011 Guillen-Ahlers H, Tan J, Castellino FJ, Ploplis VA. Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29. Plos One. 6: e25725. PMID 21991341 DOI: 10.1371/journal.pone.0025725  1
2011 Ploplis VA. Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease. Current Drug Targets. 12: 1782-9. PMID 21707474 DOI: 10.2174/138945011797635803  1
2011 Balsara RD, Merryman R, Virjee F, Northway C, Castellino FJ, Ploplis VA. A deficiency of uPAR alters endothelial angiogenic function and cell morphology. Vascular Cell. 3: 10. PMID 21535874 DOI: 10.1186/2045-824X-3-10  1
2011 Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M. An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood. 117: 283-9. PMID 20858853 DOI: 10.1182/blood-2010-07-299057  1
2010 Iwaki T, Malinverno C, Smith D, Xu Z, Liang Z, Ploplis VA, Castellino FJ. The generation and characterization of mice expressing a plasmin-inactivating active site mutation. Journal of Thrombosis and Haemostasis : Jth. 8: 2341-4. PMID 20653841 DOI: 10.1111/j.1538-7836.2010.03995.x  1
2010 Xu Z, Xu H, Ploplis VA, Castellino FJ. Factor VII deficiency impairs cutaneous wound healing in mice. Molecular Medicine (Cambridge, Mass.). 16: 167-76. PMID 20454518 DOI: 10.2119/molmed.2009.00171  1
2010 Guillen-Ahlers H, Suckow MA, Castellino FJ, Ploplis VA. Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. Plos One. 5: e9070. PMID 20140201 DOI: 10.1371/journal.pone.0009070  1
2010 Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood. 115: 2038-47. PMID 20009036 DOI: 10.1182/blood-2009-09-244962  0.56
2009 Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. Journal of Thrombosis and Haemostasis : Jth. 7: 140-5. PMID 19630787 DOI: 10.1111/j.1538-7836.2009.03410.x  1
2009 Shinagawa K, Ploplis VA, Castellino FJ. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 296: L763-70. PMID 19286924 DOI: 10.1152/ajplung.90638.2008  1
2009 Tang H, Fu Y, Lei Q, Han Q, Ploplis VA, Castellino FJ, Li L, Luo Y. Fibrinogen facilitates the anti-tumor effect of nonnative endostatin. Biochemical and Biophysical Research Communications. 380: 249-53. PMID 19167351 DOI: 10.1016/j.bbrc.2009.01.045  1
2009 Tang H, Fu Y, Cui Y, He Y, Zeng X, Ploplis VA, Castellino FJ, Luo Y. Fibrinogen has chaperone-like activity. Biochemical and Biophysical Research Communications. 378: 662-7. PMID 19059206 DOI: 10.1016/j.bbrc.2008.11.112  1
2009 Xu H, Noria F, Sandoval-Cooper MJ, Menchen H, Donahue DL, Ploplis VA, Castellino FJ. Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice. The Journal of Pathology. 217: 362-71. PMID 18973189 DOI: 10.1002/path.2454  1
2008 Balsara RD, Ploplis VA. Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thrombosis and Haemostasis. 100: 1029-36. PMID 19132226 DOI: 10.1160/TH08-07-0427  1
2008 Guillen-Ahlers H, Buechler SA, Suckow MA, Castellino FJ, Ploplis VA. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis. 29: 1421-7. PMID 18499699 DOI: 10.1093/carcin/bgn123  1
2008 Castellino FJ, Ploplis VA, Zhang L. gamma-Glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 446: 85-94. PMID 18373251 DOI: 10.1007/978-1-60327-084-7_6  1
2008 Iwaki T, Ploplis VA, Castellino FJ. The hemostasis system in murine atherosclerosis. Current Drug Targets. 9: 229-38. PMID 18336242 DOI: 10.2174/138945008783755593  1
2008 Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ. The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. The Journal of Biological Chemistry. 283: 1580-7. PMID 18039665 DOI: 10.1074/jbc.M705063200  1
2008 Castellino FJ, Ploplis VA, Zhang L. γ-glutamate and β-hydroxyaspartate in proteins Methods in Molecular Biology. 446: 85-94. DOI: 10.1007/978-1-60327-84-7_6  1
2007 Balsara RD, Xu Z, Ploplis VA. Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice. Current Drug Targets. 8: 982-95. PMID 17896950 DOI: 10.2174/138945007781662382  1
2007 Ploplis VA, Tipton H, Menchen H, Castellino FJ. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. The Journal of Pathology. 213: 266-74. PMID 17893885 DOI: 10.1002/path.2236  1
2007 Shinagawa K, Martin JA, Ploplis VA, Castellino FJ. Coagulation factor Xa modulates airway remodeling in a murine model of asthma. American Journal of Respiratory and Critical Care Medicine. 175: 136-43. PMID 17082493 DOI: 10.1164/rccm.200608-1097OC  1
2006 Castellino FJ, Ganopolsky JG, Noria F, Sandoval-Cooper MJ, Ploplis VA. Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene. Thrombosis and Haemostasis. 96: 794-801. PMID 17139375 DOI: 10.1160/TH06-08-0430  1
2006 Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. The Journal of Pathology. 210: 488-96. PMID 17054310 DOI: 10.1002/path.2073  1
2006 Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ. Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice. The Journal of Pathology. 210: 325-33. PMID 16981239 DOI: 10.1002/path.2060  1
2006 Balsara RD, Castellino FJ, Ploplis VA. A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. The Journal of Biological Chemistry. 281: 22527-36. PMID 16785241 DOI: 10.1074/jbc.M512819200  1
2006 Kwak SH, Wang XQ, He Q, Fang WF, Mitra S, Bdeir K, Ploplis VA, Xu Z, Idell S, Cines D, Abraham E. Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway. Thrombosis and Haemostasis. 95: 829-35. PMID 16676075 DOI: 10.1160/TH05-12-0782  1
2006 Iwaki T, Sandoval-Cooper MJ, Brechmann M, Ploplis VA, Castellino FJ. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood. 107: 3883-91. PMID 16434491 DOI: 10.1182/blood-2005-09-3780  1
2005 Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system. Thrombosis and Haemostasis. 93: 647-54. PMID 15841308 DOI: 10.1267/THRO05040647  1
2004 Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF. A central role for plasminogen in the inflammatory response to biomaterials. Journal of Thrombosis and Haemostasis : Jth. 2: 1798-805. PMID 15456492 DOI: 10.1111/j.1538-7836.2004.00916.x  1
2004 Xu Z, Balsara RD, Gorlatova NV, Lawrence DA, Castellino FJ, Ploplis VA. Conservation of critical functional domains in murine plasminogen activator inhibitor-1. The Journal of Biological Chemistry. 279: 17914-20. PMID 14963029 DOI: 10.1074/jbc.M314197200  1
2004 Ploplis VA, Balsara R, Sandoval-Cooper MJ, Yin ZJ, Batten J, Modi N, Gadoua D, Donahue D, Martin JA, Castellino FJ. Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. The Journal of Biological Chemistry. 279: 6143-51. PMID 14625301 DOI: 10.1074/jbc.M307297200  1
2003 Iwaki T, Figuera M, Ploplis VA, Castellino FJ. Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques. 35: 482-4, 486. PMID 14513552  1
2003 Paoni NF, Feldman MW, Gutierrez LS, Ploplis VA, Castellino FJ. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiological Genomics. 15: 228-35. PMID 13130079 DOI: 10.1152/physiolgenomics.00078.2003  1
2003 Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. The American Journal of Pathology. 163: 517-31. PMID 12875972 DOI: 10.1016/S0002-9440(10)63680-2  1
2003 Gutierrez LS, Suckow M, Lawler J, Ploplis VA, Castellino FJ. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 24: 199-207. PMID 12584168 DOI: 10.1093/carcin/24.2.199  1
2002 Zeng B, Bruce D, Kril J, Ploplis V, Freedman B, Brieger D. Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: Studies in plasminogen knock-out mice Thrombosis and Haemostasis. 88: 805-810. PMID 12428098  1
2002 Castellino FJ, Ploplis VA, Zhang L. gamma-glutamate and beta-hydroxyaspartate in proteins. Methods in Molecular Biology (Clifton, N.J.). 194: 259-68. PMID 12029840 DOI: 10.1385/1-59259-181-7:259  1
2002 Iwaki T, Sandoval-Cooper MJ, Paiva M, Kobayashi T, Ploplis VA, Castellino FJ. Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. The American Journal of Pathology. 160: 1021-34. PMID 11891199 DOI: 10.1016/S0002-9440(10)64923-1  1
2002 Ploplis VA, Castellino FJ. Gene targeting of components of the fibrinolytic system. Thrombosis and Haemostasis. 87: 22-31. PMID 11848453  1
2001 Chan JC, Duszczyszyn DA, Castellino FJ, Ploplis VA. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. The American Journal of Pathology. 159: 1681-8. PMID 11696429 DOI: 10.1016/S0002-9440(10)63015-5  1
2001 Wilberding JA, Ploplis VA, McLennan L, Liang Z, Cornelissen I, Feldman M, Deford ME, Rosen ED, Castellino FJ. Development of pulmonary fibrosis in fibrinogen-deficient mice. Annals of the New York Academy of Sciences. 936: 542-8. PMID 11460513  1
2001 Ploplis VA, Castellino FJ. Attenuation of neointima formation following arterial injury in PAI-1 deficient mice. Annals of the New York Academy of Sciences. 936: 466-8. PMID 11460504  1
2001 Ploplis VA. Gene targeting in hemostasis. plasminogen. Frontiers in Bioscience : a Journal and Virtual Library. 6: D555-69. PMID 11229877  1
2001 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ. The characterization of mice with a targeted combined deficiency of protein c and factor XI. The American Journal of Pathology. 158: 469-79. PMID 11159184 DOI: 10.1016/S0002-9440(10)63989-2  1
2001 Ploplis VA, Cornelissen I, Sandoval-Cooper MJ, Weeks L, Noria FA, Castellino FJ. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. The American Journal of Pathology. 158: 107-17. PMID 11141484 DOI: 10.1016/S0002-9440(10)63949-1  1
2000 Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ. Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Research. 60: 5839-47. PMID 11059781  1
2000 Ploplis VA, Wilberding J, McLennan L, Liang Z, Cornelissen I, DeFord ME, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. The American Journal of Pathology. 157: 703-8. PMID 10980108 DOI: 10.1016/S0002-9440(10)64582-8  1
2000 Swaisgood CM, French EL, Noga C, Simon RH, Ploplis VA. The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. The American Journal of Pathology. 157: 177-87. PMID 10880388 DOI: 10.1016/S0002-9440(10)64529-4  1
2000 Busuttil SJ, Drumm C, Ploplis VA, Plow EF. Endoluminal arterial injury in plasminogen-deficient mice. The Journal of Surgical Research. 91: 159-64. PMID 10839966 DOI: 10.1006/jsre.2000.5922  1
2000 Ploplis VA, Castellino FJ. Nonfibrinolytic functions of plasminogen. Methods (San Diego, Calif.). 21: 103-10. PMID 10816371 DOI: 10.1006/meth.2000.0981  1
2000 Chan JC, Cornelissen I, Collen D, Ploplis VA, Castellino FJ. Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. The Journal of Clinical Investigation. 105: 897-903. PMID 10749569 DOI: 10.1172/JCI9095  1
2000 Ploplis VA, Cornelissen I, Paul C, Sandoval-Cooper M, Castellino FJ. Two novel vascular injury models demonstrate a role for urokinase in early vascular repair events Fibrinolysis and Proteolysis. 14: 20.  1
2000 Ploplis VA, Wilberding J, Cornelissen I, Defokdm E, Uang Z, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice Fibrinolysis and Proteolysis. 14: 11.  1
1999 Hoover-Plow J, Wang N, Ploplis V. Growth and behavioral development in plasminogen gene-targeted mice Growth, Development and Aging. 63: 13-32. PMID 10885855  1
1999 Plow EF, Ploplis VA, Busuttil S, Carmeliet P, Collen D. A role of plasminogen in atherosclerosis and restenosis models in mice. Thrombosis and Haemostasis. 82: 4-7. PMID 10695477  1
1999 Ny A, Leonardsson G, Hägglund AC, Hägglöf P, Ploplis VA, Carmeliet P, Ny T. Ovulation in plasminogen-deficient mice. Endocrinology. 140: 5030-5. PMID 10537128 DOI: 10.1210/endo.140.11.7113  1
1999 Li Z, Ploplis VA, French EL, Boyle MD. Interaction between group A streptococci and the plasmin(ogen) system promotes virulence in a mouse skin infection model. The Journal of Infectious Diseases. 179: 907-14. PMID 10068586 DOI: 10.1086/314654  1
1999 Plow EF, Ploplis VA, Carmeliet P, Collen D. Plasminogen and cell migration in vivo Fibrinolysis and Proteolysis. 13: 49-53.  1
1998 Rosenthal PJ, Semenov A, Ploplis VA, Plow EF. Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites. Molecular and Biochemical Parasitology. 97: 253-7. PMID 9879906 DOI: 10.1016/S0166-6851(98)00142-X  1
1998 Moons L, Shi C, Ploplis V, Plow E, Haber E, Collen D, Carmeliet P. Reduced transplant arteriosclerosis in plasminogen-deficient mice. The Journal of Clinical Investigation. 102: 1788-97. PMID 9819364 DOI: 10.1172/JCI3316  1
1998 Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF. Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood. 91: 2005-9. PMID 9490683  1
1998 Swaisgood C, French E, Ploplis V. Pathological consequences associated with altered expression of components of the plasminogen system in bleomycin induced pulmonary fibrosis Fibrinolysis and Proteolysis. 12: 32.  1
1997 Carmeliet P, Moons L, Dewerchin M, Mackman N, Luther T, Breier G, Ploplis V, Müller M, Nagy A, Plow E, Gerard R, Edgington T, Risau W, Collen D. Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system Annals of the New York Academy of Sciences. 811: 191-206. PMID 9186598 DOI: 10.1111/j.1749-6632.1997.tb52002.x  1
1997 Kitching AR, Holdsworth SR, Ploplis VA, Plow EF, Collen D, Carmeliet P, Tipping PG. Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. The Journal of Experimental Medicine. 185: 963-8. PMID 9120402 DOI: 10.1084/jem.185.5.963  1
1997 Carmeliet P, Moons L, Ploplis V, Plow E, Collen D. Impaired arterial neointima formation in mice with disruption of the Plasminogen gene Journal of Clinical Investigation. 99: 200-208. PMID 9005988  1
1997 Ny A, Leonardsson G, Hägglund AC, Hägglöf P, Ploplis VA, Carmeliet P, Ny T. Physiological consequenses of plasminogen deficiency on fertility and ovulation efficiency Fibrinolysis and Proteolysis. 11: 19.  1
1997 Swaisyood CM, French E, Ploplis V. The plasminogen system in pulmonary fibrosis Fibrinolysis and Proteolysis. 11: 19.  1
1997 Moons L, Shi C, Ploplis V. Reduced transplant arteriosclerosis in plasminogen deficient mice Fibrinolysis and Proteolysis. 11: 22.  1
1996 Lijnen HR, Carmeliet P, Bouché A, Moons L, Ploplis VA, Plow EF, Collen D. Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen. Blood. 88: 870-6. PMID 8704243  1
1996 Ploplis V, French E, Carmeliet P, Collen D, Plow E. The plasminogen system and cell migration during an inflammatory response Fibrinolysis. 10: 19.  1
1996 Carmeliet P, Moons L, Dewerchin M, Ploplis V, De Mol M, Stassen JM, Declercq C, Plow E, Gerard R, Collen D. Receptor-independent plasminogen activation by urokinase-type plasminogen activator promotes, and adenoviral pai-1 gene transfer inhibits arterial neointima formation in mice Fibrinolysis. 10: 19.  1
1996 Kitching AR, Carmeliet P, Ploplis V, Collen D, Plow E, Holdsworth ER, Tipping P. Glomerulonephritis in mice with genetic deficiencies of the plasminogen system Fibrinolysis. 10: 80.  1
1995 Hooper DC, Molowitz EH, Bos NA, Ploplis VA, Cebra JJ. Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens. European Journal of Immunology. 25: 212-7. PMID 7843233 DOI: 10.1002/eji.1830250135  1
1995 Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, Collen D. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation. 92: 2585-93. PMID 7586361  1
1994 Bos NA, Ploplis VA. Humoral immune response to 2,4-dinitrophenyl--keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice. European Journal of Immunology. 24: 59-65. PMID 8020572 DOI: 10.1002/eji.1830240110  1
1993 Gargan PE, Gaffney PJ, Pleasants JR, Ploplis VA. A monoclonal antibody which recognises an epitopic region unique to the intact fibrin polymeric structure Fibrinolysis and Proteolysis. 7: 275-283. DOI: 10.1016/0268-9499(93)90136-J  1
1992 McLinden JH, Ploplis VA, Fraser MJ, Rosen ED. Expression of foreign epitopes on recombinant occlusion bodies of baculoviruses. Vaccine. 10: 231-7. PMID 1373262  1
1991 Miller KM, Wible JH, Coveney JR, Lyle LR, Gargan PE, Ploplis VA, Fritzberg AR. Using technetium-99m MH-1 monoclonal antibody to image thrombi in a rabbit jugular vein Journal of Labelled Compounds and Radiopharmaceuticals. 30: 322.  1
1990 Gargan PE, DaMatta RA, Silverman T, Ploplis VA. Immunochemical evidence for intramolecular interaction of the carboxy terminal A alpha-appendages of plasma fibrinogen. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis. 1: 457-60. PMID 1723303  1
1989 Whitefleet-Smith J, Rosen E, McLinden J, Ploplis VA, Fraser MJ, Tomlinson JE, McLean JW, Castellino FJ. Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system. Archives of Biochemistry and Biophysics. 271: 390-9. PMID 2658810 DOI: 10.1016/0003-9861(89)90288-9  1
1988 Gargan PE, Ploplis VA, Scheu JD. A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator. Thrombosis and Haemostasis. 59: 426-31. PMID 3142080  1
1987 Ploplis VA, Edgington TS, Fair DS. Initiation of the extrinsic pathway of coagulation. Association of factor VIIa with a cell line expressing tissue factor. The Journal of Biological Chemistry. 262: 9503-8. PMID 3496335  1
1984 Cummings HS, Ploplis VA, Beals JM, Castellino FJ. Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen. Archives of Biochemistry and Biophysics. 230: 306-15. PMID 6201139 DOI: 10.1016/0003-9861(84)90112-7  1
1982 Ploplis VA, Cummings HS, Castellino FJ. Monoclonal antibodies to discrete regions of human Glu1-plasminogen. Biochemistry. 21: 5891-7. PMID 6185142 DOI: 10.1021/bi00266a025  1
1981 Ploplis VA, Strickland DK, Castellino FJ. Calorimetric evaluation of the existence of separate domains in bovine prothrombin. Biochemistry. 20: 15-21. PMID 7470466 DOI: 10.1021/bi00504a003  1
1981 Castellino FJ, Ploplis VA, Powell JR, Strickland DK. The existence of independent domain structures in human Lys77-plasminogen. The Journal of Biological Chemistry. 256: 4778-82. PMID 7228856  1
1979 Ploplis VA, Thomas JK, Castellino FJ. Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein. Chemistry and Physics of Lipids. 23: 49-62. PMID 221125 DOI: 10.1016/0009-3084(79)90022-7  1
1977 Castellino FJ, Thomas JK, Ploplis VA. Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein. Biochemical and Biophysical Research Communications. 75: 857-62. PMID 193504 DOI: 10.1016/0006-291X(77)91461-9  1
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