Peng R. Chen, Ph.D. - Publications

Affiliations: 
Peking University Peking University, Beijing, Beijing Shi, China 
Area:
Chemical Biology

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C, Chen PR. Time-resolved protein activation by proximal decaging in living systems. Nature. PMID 31068699 DOI: 10.1038/s41586-019-1188-1  1
2019 Zhao J, Liu Y, Lin F, Wang W, Yang S, Ge Y, Chen PR. Bioorthogonal Engineering of Bacterial Effectors for Spatial-Temporal Modulation of Cell Signaling. Acs Central Science. 5: 145-152. PMID 30693333 DOI: 10.1021/acscentsci.8b00751  1
2019 Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen PR. Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions. Journal of the American Chemical Society. PMID 30676735 DOI: 10.1021/jacs.8b10286  1
2018 Yao Q, Lin F, Fan X, Wang Y, Liu Y, Liu Z, Jiang X, Chen PR, Gao Y. Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. Nature Communications. 9: 5032. PMID 30487642 DOI: 10.1038/s41467-018-07490-6  1
2018 He D, Zhang M, Liu S, Xie X, Chen PR. Protease-Mediated Protein Quality Control for Bacterial Acid Resistance. Cell Chemical Biology. PMID 30472118 DOI: 10.1016/j.chembiol.2018.10.014  1
2018 Zheng H, Lin S, Chen PR. Genetic Code Expansion in Enteric Bacterial Pathogens. Methods in Molecular Biology (Clifton, N.J.). 1728: 113-126. PMID 29404993 DOI: 10.1007/978-1-4939-7574-7_6  1
2017 Hao Z, Zhu R, Chen PR. Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems. Current Opinion in Chemical Biology. 43: 87-96. PMID 29275290 DOI: 10.1016/j.cbpa.2017.12.002  1
2017 Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229866 DOI: 10.1073/pnas.1708563115  1
2017 Duan HC, Wei LH, Zhang C, Wang Y, Chen L, Lu Z, Chen PR, He C, Jia G. ALKBH10B is An RNA N6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition. The Plant Cell. PMID 29180595 DOI: 10.1105/tpc.16.00912  1
2017 Liu L, Liu Y, Zhang G, Ge Y, Fan X, Lin F, Wang J, Zheng H, Xie X, Zeng X, Chen PR. Genetically encoded chemical decaging in living bacteria. Biochemistry. PMID 29171270 DOI: 10.1021/acs.biochem.7b01017  1
2017 He D, Xie X, Yang F, Zhang H, Su H, Ge Y, Song H, Chen P. Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker. Angewandte Chemie (International Ed. in English). PMID 28940571 DOI: 10.1002/anie.201708151  1
2017 Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen PR. Genetically encoded releasable photo-cross-linking strategies for studying protein-protein interactions in living cells. Nature Protocols. 12: 2147-2168. PMID 28933779 DOI: 10.1038/nprot.2017.090  1
2017 Male AL, Forafonov F, Cuda F, Zhang G, Zheng S, Oyston PCF, Chen PR, Williamson ED, Tavassoli A. Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction. Scientific Reports. 7: 3104. PMID 28596569 DOI: 10.1038/s41598-017-03253-3  1
2017 Zheng S, Fan X, Wang J, Zhao J, Chen P. Dissection of kinase isoforms via orthogonal and chemical inducible signaling cascades. Chembiochem : a European Journal of Chemical Biology. PMID 28561913 DOI: 10.1002/cbic.201700255  1
2017 Zhang S, He D, Lin Z, Yang Y, Song H, Chen PR. Conditional Chaperone-Client Interactions Revealed by Genetically Encoded Photo-cross-linkers. Accounts of Chemical Research. PMID 28467057 DOI: 10.1021/acs.accounts.6b00647  1
2017 Xie X, Li XM, Qin F, Lin J, Zhang G, Zhao J, Bao X, Zhu R, Song H, Li XD, Chen PR. Genetically Encoded Photoaffinity Histone Marks. Journal of the American Chemical Society. PMID 28459554 DOI: 10.1021/jacs.7b01431  1
2017 Zhu R, Hao Z, Lou H, Song Y, Zhao J, Chen Y, Zhu J, Chen PR. Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 28124121 DOI: 10.1007/s00775-017-1442-7  1
2016 Ge Y, Fan X, Chen PR. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chemical Science. 7: 7055-7060. PMID 28451140 DOI: 10.1039/c6sc02615j  1
2016 Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J, Chen PR. Palladium-triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-caged Tyrosine. Journal of the American Chemical Society. PMID 27797486 DOI: 10.1021/jacs.6b08933  1
2016 Fan X, Ge Y, Lin F, Yang Y, Zhang G, Ngai WS, Lin Z, Zheng S, Wang J, Zhao J, Li J, Chen PR. Optimized Tetrazine Derivatives for Rapid Bioorthogonal Decaging in Living Cells. Angewandte Chemie (International Ed. in English). PMID 27735133 DOI: 10.1002/anie.201608009  1
2016 Yang Y, Song H, Chen PR. Genetically encoded photocrosslinkers for identifying and mapping protein-protein interactions in living cells. Iubmb Life. PMID 27670842 DOI: 10.1002/iub.1560  1
2016 Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S, Chen PR. Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621474 DOI: 10.1073/pnas.1606360113  1
2016 Yang M, Yang Y, Chen PR. Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions. Topics in Current Chemistry (Journal). 374: 2. PMID 27572985 DOI: 10.1007/s41061-015-0001-3  1
2016 Chen L, Cohen J, Song X, Zhao A, Ye Z, Feulner CJ, Doonan P, Somers W, Lin L, Chen PR. Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency. Scientific Reports. 6: 31899. PMID 27534437 DOI: 10.1038/srep31899  1
2016 Yang Y, Song H, He D, Zhang S, Dai S, Lin S, Meng R, Wang C, Chen PR. Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nature Communications. 7: 12299. PMID 27460181 DOI: 10.1038/ncomms12299  1
2016 Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen PR. Bioorthogonal Chemical Activation of Kinases in Living Systems. Acs Central Science. 2: 325-31. PMID 27280167 DOI: 10.1021/acscentsci.6b00024  1
2016 Li J, Chen PR. Development and application of bond cleavage reactions in bioorthogonal chemistry. Nature Chemical Biology. 12: 129-37. PMID 26881764 DOI: 10.1038/nchembio.2024  1
2015 Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, ... ... Chen PR, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nature Cell Biology. PMID 26479318 DOI: 10.1038/ncb3255  1
2015 Hackenberger CP, Chen PR. Editorial overview: Synthetic biomolecules: Synthetic protein modifications-a giant leap towards understanding and generating biological functions. Current Opinion in Chemical Biology. PMID 26403808 DOI: 10.1016/j.cbpa.2015.09.005  1
2015 Song Y, Yang M, Wegner SV, Zhao J, Zhu R, Wu Y, He C, Chen PR. A Genetically Encoded FRET Sensor for Intracellular Heme. Acs Chemical Biology. 10: 1610-5. PMID 25860383 DOI: 10.1021/cb5009734  0.96
2015 Zhang G, Zheng S, Liu H, Chen PR. Illuminating biological processes through site-specific protein labeling. Chemical Society Reviews. 44: 3405-17. PMID 25857695 DOI: 10.1039/c4cs00393d  1
2015 Wang J, Cheng B, Li J, Zhang Z, Hong W, Chen X, Chen PR. Chemical remodeling of cell-surface sialic acids through a palladium-triggered bioorthogonal elimination reaction. Angewandte Chemie (International Ed. in English). 54: 5364-8. PMID 25765364 DOI: 10.1002/anie.201409145  1
2014 Li J, Jia S, Chen PR. Diels-Alder reaction-triggered bioorthogonal protein decaging in living cells. Nature Chemical Biology. 10: 1003-5. PMID 25362360 DOI: 10.1038/nchembio.1656  1
2014 Yang M, Jalloh AS, Wei W, Zhao J, Wu P, Chen PR. Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli. Nature Communications. 5: 4981. PMID 25236616 DOI: 10.1038/ncomms5981  1
2014 Lin S, He D, Long T, Zhang S, Meng R, Chen PR. Genetically encoded cleavable protein photo-cross-linker. Journal of the American Chemical Society. 136: 11860-3. PMID 25084056 DOI: 10.1021/ja504371w  1
2014 Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, ... ... Chen PR, et al. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell. 55: 552-65. PMID 25042803 DOI: 10.1016/j.molcel.2014.06.020  1
2014 Lin S, Chen PR. Virus engineering: Fighting HIV at its own game. Nature Chemistry. 6: 566-8. PMID 24950325 DOI: 10.1038/nchem.1987  1
2014 Cheng M, Zhang W, Yuan J, Luo W, Li N, Lin S, Yang Y, Fang X, Chen PR. Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells. Chemical Communications (Cambridge, England). 50: 14724-7. PMID 24887482 DOI: 10.1039/c4cc02804j  1
2014 Yang M, Li J, Chen PR. Transition metal-mediated bioorthogonal protein chemistry in living cells. Chemical Society Reviews. 43: 6511-26. PMID 24867400 DOI: 10.1039/c4cs00117f  1
2014 Zheng S, Zhang G, Li J, Chen PR. Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling. Angewandte Chemie (International Ed. in English). 53: 6449-53. PMID 24828812 DOI: 10.1002/anie.201403945  1
2014 Yang Y, Lin S, Lin W, Chen PR. Ligand-assisted dual-site click labeling of EGFR on living cells Chembiochem. 15: 1738-1743. PMID 24810988 DOI: 10.1002/cbic.201400057  1
2014 Li J, Yu J, Zhao J, Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen PR. Palladium-triggered deprotection chemistry for protein activation in living cells. Nature Chemistry. 6: 352-61. PMID 24651204 DOI: 10.1038/nchem.1887  1
2014 Kang M, Light K, Ai HW, Shen W, Kim CH, Chen PR, Lee HS, Solomon EI, Schultz PG. Evolution of iron(II)-finger peptides by using a bipyridyl amino acid. Chembiochem : a European Journal of Chemical Biology. 15: 822-5. PMID 24591102 DOI: 10.1002/cbic.201300727  1
2014 Fan Y, Zhao J, Yan Q, Chen PR, Zhao D. Water-soluble triscyclometalated organoiridium complex: phosphorescent nanoparticle formation, nonlinear optics, and application for cell imaging. Acs Applied Materials & Interfaces. 6: 3122-31. PMID 24517374 DOI: 10.1021/am500549y  1
2014 Ge X, Wang R, Ma J, Liu Y, Ezemaduka AN, Chen PR, Fu X, Chang Z. DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. The Febs Journal. 281: 1226-40. PMID 24373465 DOI: 10.1111/febs.12701  1
2014 Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao BS, Zeng S, Chen X, Chan J, He C, Chen PR. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli. Nature Chemical Biology. 10: 21-8. PMID 24185215 DOI: 10.1038/nchembio.1380  1
2013 Chang H, Han M, Huang W, Wei G, Chen J, Chen PR, Chen R, Zhang J, Xu T, Xu P. Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans. Protein & Cell. 4: 883-6. PMID 24293260 DOI: 10.1007/s13238-013-3118-6  0.84
2013 Lin S, Yan H, Li L, Yang M, Peng B, Chen S, Li W, Chen PR. Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus. Angewandte Chemie (International Ed. in English). 52: 13970-4. PMID 24222614 DOI: 10.1002/anie.201305787  1
2013 Zhao BS, Zhang G, Zeng S, He C, Chen PR. Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1485-9. PMID 24190510 DOI: 10.1039/c3ib40209f  1
2013 Li J, Lin S, Wang J, Jia S, Yang M, Hao Z, Zhang X, Chen PR. Ligand-free palladium-mediated site-specific protein labeling inside gram-negative bacterial pathogens. Journal of the American Chemical Society. 135: 7330-8. PMID 23641876 DOI: 10.1021/ja402424j  1
2013 Zhao J, Lin S, Huang Y, Chen PR. Mechanism-based design of a photoactivatable firefly luciferase Journal of the American Chemical Society. 135: 7410-7413. PMID 23621567 DOI: 10.1021/ja4013535  1
2013 Liu J, Karpus J, Wegner SV, Chen PR, He C. Genetically encoded copper(I) reporters with improved response for use in imaging. Journal of the American Chemical Society. 135: 3144-9. PMID 23360467 DOI: 10.1021/ja3106779  1
2012 Wang J, Karpus J, Zhao BS, Luo Z, Chen PR, He C. A selective fluorescent probe for carbon monoxide imaging in living cells. Angewandte Chemie (International Ed. in English). 51: 9652-6. PMID 22930547 DOI: 10.1002/anie.201203684  1
2012 Li J, Chen PR. Moving Pd-Mediated Protein Cross Coupling to Living Systems Chembiochem. 13: 1728-1731. PMID 22764130 DOI: 10.1002/cbic.201200353  1
2012 Yang M, Song Y, Zhang M, Lin S, Hao Z, Liang Y, Zhang D, Chen PR. Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity. Angewandte Chemie (International Ed. in English). 51: 7674-9. PMID 22764096 DOI: 10.1002/anie.201204029  1
2012 Li YM, Yang MY, Huang YC, Li YT, Chen PR, Liu L. Ligation of expressed protein α-hydrazides via genetic incorporation of an α-hydroxy acid. Acs Chemical Biology. 7: 1015-22. PMID 22424086 DOI: 10.1021/cb300020s  1
2011 Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z, Chen PR. Site-specific incorporation of photo-cross-linker and bioorthogonal amino acids into enteric bacterial pathogens. Journal of the American Chemical Society. 133: 20581-7. PMID 22084898 DOI: 10.1021/ja209008w  1
2011 Zhang M, Lin S, Song X, Liu J, Fu Y, Ge X, Fu X, Chang Z, Chen PR. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nature Chemical Biology. 7: 671-7. PMID 21892184 DOI: 10.1038/nchembio.644  1
2011 Ai HW, Shen W, Sagi A, Chen PR, Schultz PG. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1854-7. PMID 21678540 DOI: 10.1002/cbic.201100194  1
2011 Hao Z, Hong S, Chen X, Chen PR. Introducing bioorthogonal functionalities into proteins in living cells. Accounts of Chemical Research. 44: 742-51. PMID 21634380 DOI: 10.1021/ar200067r  1
2011 Hao Z, Song Y, Lin S, Yang M, Liang Y, Wang J, Chen PR. A readily synthesized cyclic pyrrolysine analogue for site-specific protein "click" labeling. Chemical Communications (Cambridge, England). 47: 4502-4. PMID 21387054 DOI: 10.1039/c1cc00024a  1
2011 Chen PR, Brugarolas P, He C. Redox signaling in human pathogens. Antioxidants & Redox Signaling. 14: 1107-18. PMID 20578795 DOI: 10.1089/ars.2010.3374  1
2010 Zhao BS, Liang Y, Song Y, Zheng C, Hao Z, Chen PR. A highly selective fluorescent probe for visualization of organic hydroperoxides in living cells. Journal of the American Chemical Society. 132: 17065-7. PMID 21077671 DOI: 10.1021/ja1071114  1
2010 Groff D, Chen PR, Peters FB, Schultz PG. A genetically encoded epsilon-N-methyl lysine in mammalian cells. Chembiochem : a European Journal of Chemical Biology. 11: 1066-8. PMID 20422671 DOI: 10.1002/cbic.200900690  1
2009 Poor CB, Chen PR, Duguid E, Rice PA, He C. Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus. The Journal of Biological Chemistry. 284: 23517-24. PMID 19586910 DOI: 10.1074/jbc.M109.015826  1
2009 Chen PR, Groff D, Guo J, Ou W, Cellitti S, Geierstanger BH, Schultz PG. A facile system for encoding unnatural amino acids in mammalian cells. Angewandte Chemie (International Ed. in English). 48: 4052-5. PMID 19378306 DOI: 10.1002/anie.200900683  1
2009 Chen PR, Nishida S, Poor CB, Cheng A, Bae T, Kuechenmeister L, Dunman PM, Missiakas D, He C. A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus. Molecular Microbiology. 71: 198-211. PMID 19007410 DOI: 10.1111/j.1365-2958.2008.06518.x  1
2008 Chen H, Hu J, Chen PR, Lan L, Li Z, Hicks LM, Dinner AR, He C. The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 105: 13586-91. PMID 18757728 DOI: 10.1073/pnas.0803391105  1
2008 Chen PR, He C. Selective recognition of metal ions by metalloregulatory proteins. Current Opinion in Chemical Biology. 12: 214-21. PMID 18258210 DOI: 10.1016/j.cbpa.2007.12.010  1
2007 Chen PR, Wasinger EC, Zhao J, van der Lelie D, Chen LX, He C. Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691. Journal of the American Chemical Society. 129: 12350-1. PMID 17880216 DOI: 10.1021/ja0733890  1
2007 Sarkar SK, Andoy NM, Benítez JJ, Chen PR, Kong JS, He C, Chen P. Engineered holliday junctions as single-molecule reporters for protein-DNA interactions with application to a MerR-family regulator. Journal of the American Chemical Society. 129: 12461-7. PMID 17880214 DOI: 10.1021/ja072485y  1
2006 Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C. An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nature Chemical Biology. 2: 591-5. PMID 16980961 DOI: 10.1038/nchembio820  1
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