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Marcos M. Sotomayor - Publications

Affiliations: 
Chemistry and Biochemistry Ohio State University, Columbus, Columbus, OH 
Area:
Mechanotransduction - Cellular Adhesion - Structural Biology - Molecular Dynamics Simulations - Protein Biochemistry and Biophysics
Website:
http://chemistry.osu.edu/faculty/sotomayor

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Neel BL, Nisler CR, Walujkar S, Araya-Secchi R, Sotomayor M. Elastic versus Brittle Mechanical Responses Predicted for Dimeric Cadherin Complexes. Biophysical Journal. PMID 35151631 DOI: 10.1016/j.bpj.2022.02.007  0.319
2021 Ahmed T, Nisler CR, Fluck EC, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure (London, England : 1993). PMID 34453887 DOI: 10.1016/j.str.2021.08.003  0.362
2020 Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M. Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proceedings of the National Academy of Sciences of the United States of America. PMID 32963095 DOI: 10.1073/pnas.1920444117  0.367
2020 Tamilselvan E, Sotomayor MM. Elucidating the Adhesive Mechanism of the Atypical Cadherin CELSR1 Involved in Planar Cell Polarity Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.677  0.32
2020 Neel BL, Sotomayor MM. Utilizing Molecular Dynamics Simulations to Probe the Release of Signal Factors from the Adherens Junction Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1620  0.3
2020 Lotthammer J, Walujkar S, Wimalasena LN, Sotomayor MM. In-Silico Electrophysiology of Inner-Ear Mechanotransduction Channel Models Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1582  0.404
2020 Nisler C, Narui Y, Lynch V, Sotomayor MM. The Evolutionary Biophysics of A Force-Conveying Protein Complex Required for Vertebrate Hearing Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1044  0.343
2019 Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R. Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31431536 DOI: 10.1073/Pnas.1821063116  0.609
2019 Park MS, Araya-Secchi R, Brackbill JA, Phan HD, Kehling AC, Abd El-Wahab EW, Dayeh DM, Sotomayor M, Nakanishi K. Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters. Molecular Cell. PMID 31324450 DOI: 10.1016/J.Molcel.2019.06.011  0.334
2019 Neel BL, Klanseck CF, Sotomayor M. Structure of a Non-Canonical and Flexible Middle Domain in Inner-Ear Protocadherin-15 Biophysical Journal. 116: 48a. DOI: 10.1016/J.Bpj.2018.11.302  0.316
2019 Pan B, Akyuz N, Liu X, Asai Y, Nist-Lund C, Kurima K, Derfler B, György B, Limapichat W, Walujkar S, Wimalasena L, Sotomayor M, Corey D, Holt JR. Cysteine Substitution Reveals the Pore-Forming Region of TMC1 in Hair Cell Sensory Transduction Channels Biophysical Journal. 116: 460a. DOI: 10.1016/J.Bpj.2018.11.2486  0.772
2019 De-la-Torre P, Narui Y, Choudhary D, Araya-Secchi R, Sotomayor M. Structures and Simulations of Membrane Adjacent Fragments of Protocadherin-15 Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2480  0.316
2019 Walujkar S, Wimalasena LN, Lotthammer J, Sotomayor M. Molecular Dynamics Simulations of TMC1 Homology Models Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1320  0.314
2018 De-la-Torre P, Choudhary D, Araya-Secchi R, Narui Y, Sotomayor M. A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. Biophysical Journal. 115: 2368-2385. PMID 30527337 DOI: 10.1016/J.Bpj.2018.11.010  0.451
2018 Chen TH, Sotomayor M, Gopalan V. Biochemical Studies Provide Insights into the Necessity for MultipleArabidopsis thalianaProtein-Only RNase P Isoenzymes. Journal of Molecular Biology. PMID 30414965 DOI: 10.1016/J.Jmb.2018.11.004  0.354
2018 Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 99: 736-753.e6. PMID 30138589 DOI: 10.1016/J.Neuron.2018.07.033  0.791
2018 Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure (London, England : 1993). PMID 30033219 DOI: 10.1016/J.Str.2018.06.003  0.382
2018 Narui Y, Sotomayor M. Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15 Biochemistry. 57: 1702-1710. PMID 29443515 DOI: 10.1021/Acs.Biochem.7B01075  0.421
2018 Jaiganesh A, Narui Y, Araya-Secchi R, Sotomayor M. Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance. Cold Spring Harbor Perspectives in Biology. 10. PMID 28847902 DOI: 10.1101/Cshperspect.A029280  0.471
2017 Choudhary D, Kumar A, Magliery TJ, Sotomayor M. Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins. Plos One. 12: e0189546. PMID 29261728 DOI: 10.1371/Journal.Pone.0189546  0.384
2017 Powers RE, Gaudet R, Sotomayor M. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure (London, England : 1993). PMID 28238533 DOI: 10.1016/J.Str.2017.01.014  0.627
2017 Jaiganesh A, Patel A, De-la-Torre P, Termine D, Velez-Cortes F, Sotomayor M. Towards a Complete Structural Model for the Essential Inner-Ear Protein Cadherin-23 Biophysical Journal. 112: 535a. DOI: 10.1016/J.Bpj.2016.11.2892  0.345
2017 Walujkar SP, Araya-Sechhi R, Sotomayor M. Simulated Forced Unbinding of Clustered Protocadherins Biophysical Journal. 112: 449. DOI: 10.1016/J.Bpj.2016.11.2406  0.363
2017 Neel B, Nisler C, Araya-Secchi R, Sotomayor M. Large Scale Molecular Dynamics Simulations of Three Classical Cadherins Involved in Cell Adhesion Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1748  0.432
2016 Araya-Secchi R, Neel BL, Sotomayor M. An elastic element in the protocadherin-15 tip link of the inner ear. Nature Communications. 7: 13458. PMID 27857071 DOI: 10.1038/Ncomms13458  0.433
2016 Cooper SR, Jontes JD, Sotomayor M. Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy. Elife. 5. PMID 27787195 DOI: 10.7554/Elife.18529  0.319
2016 Narui Y, Velez-Cortes F, Johnson Z, Sotomayor M. Steered Molecular Dynamics Simulations of Inner-Ear Cadherins using the Drude Polarizable Force Field Biophysical Journal. 110: 177. DOI: 10.1016/J.Bpj.2015.11.988  0.407
2016 Sotomayor M, Araya-Secchi R, Narui Y, Chen C, Klanseck C, Wimalasena L. Structural Determinants of Protocadherin-15 Function in Inner-Ear Mechanotransduction Biophysical Journal. 110: 93a. DOI: 10.1016/J.Bpj.2015.11.563  0.491
2016 Choudhary D, Kumar A, Magliery TJ, Sotomayor M. Using Inner-Ear Cadherins to Test High-Throughput Thermal Screening Assays for Protein-Protein Interactions Biophysical Journal. 110: 388a-389a. DOI: 10.1016/J.Bpj.2015.11.2100  0.343
2016 Thornburg A, Sotomayor M. Resolving the Molecular Mechanisms of Inherited Deafness caused by Missense Mutations in Cadherin-23 Biophysical Journal. 110: 319a. DOI: 10.1016/J.Bpj.2015.11.1714  0.404
2016 Jaiganesh A, Kilic D, Patel A, Termine D, Velez-Cortes F, Irfan Kufrevioglu O, Sotomayor M. Structure and Stability of Tip Link Cadherin-23 Fragments Involved in Hearing and Deafness Biophysical Journal. 110: 209a. DOI: 10.1016/J.Bpj.2015.11.1162  0.396
2016 Koussa MA, Ward A, Sotomayor M, Wong WP, Corey DP. Single Molecule Force Spectroscopy of Hair-Cell Tip-Link Proteins Biophysical Journal. 110: 196a. DOI: 10.1016/J.Bpj.2015.11.1090  0.788
2015 Narui Y, Sotomayor M. Structural and Biophysical Characterization of Inner Ear Tip Link Variants Biophysical Journal. 108: 562a. DOI: 10.1016/J.Bpj.2014.11.3078  0.485
2015 Araya-Secchi R, Sotomayor M. Structure of an Inner-Ear Protocadherin-15 Fragment with an Atypical Calcium-Free Linker Biophysical Journal. 108: 561a. DOI: 10.1016/J.Bpj.2014.11.3075  0.394
2015 Powers RE, Gaudet R, Sotomayor M. Structural Study of a Novel Partial Calcium-Free Linker and a Positively Selected Variation in Protocadherin-15: Implications for Hearing and Cell Adhesion Biophysical Journal. 108: 505a. DOI: 10.1016/J.Bpj.2014.11.2765  0.642
2015 Sotomayor M. Mechanisms and Mechanosensitivity: Exceptional Cadherins for Hearing and Balance Biophysical Journal. 108: 11a-12a. DOI: 10.1016/J.Bpj.2014.11.089  0.511
2014 Sotomayor M, Gaudet R, Corey DP. Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends in Cell Biology. 24: 524-36. PMID 24794279 DOI: 10.1016/J.Tcb.2014.03.007  0.718
2014 Koussa MA, Sotomayor M, Wong WP. Protocol for sortase-mediated construction of DNA-protein hybrids and functional nanostructures. Methods (San Diego, Calif.). 67: 134-41. PMID 24568941 DOI: 10.1016/J.Ymeth.2014.02.020  0.758
2014 Sotomayor M, Gaudet R, Corey DP. Molecular Mechanisms of Deafness Mutations Disrupting Tip-Link Function in Hair-Cell Mechanotransduction Biophysical Journal. 106: 449a. DOI: 10.1016/J.Bpj.2013.11.2546  0.756
2014 Koussa MA, Sotomayor M, Wong WP, Corey DP. Force Spectroscopy of Tip Link Proteins: A Study of Inner-Ear Biophysics Biophysical Journal. 106: 386a. DOI: 10.1016/J.Bpj.2013.11.2183  0.791
2013 Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN. Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4395-404. PMID 23467356 DOI: 10.1523/Jneurosci.4514-12.2013  0.731
2013 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structures and Simulated Dynamics of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction Biophysical Journal. 104: 166a. DOI: 10.1016/J.Bpj.2012.11.937  0.769
2012 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492: 128-32. PMID 23135401 DOI: 10.1038/Nature11590  0.768
2012 Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51: 6195-206. PMID 22702953 DOI: 10.1021/Bi300279B  0.781
2012 Gumbart J, Khalili-Araghi F, Sotomayor M, Roux B. Constant electric field simulations of the membrane potential illustrated with simple systems. Biochimica Et Biophysica Acta. 1818: 294-302. PMID 22001851 DOI: 10.1016/J.Bbamem.2011.09.030  0.748
2011 Gamini R, Sotomayor M, Chipot C, Schulten K. Cytoplasmic domain filter function in the mechanosensitive channel of small conductance. Biophysical Journal. 101: 80-9. PMID 21723817 DOI: 10.1016/J.Bpj.2011.05.042  0.796
2011 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Molecular mechanics of tip-link cadherins Aip Conference Proceedings. 1403: 64-69. DOI: 10.1063/1.3658062  0.685
2011 Naranjo D, Valencia I, Moscoso C, Stack K, Márquez V, Vergara A, Sotomayor M, González-Nilo F. Ion Conduction in a Shaker Potassium Channel Mutant Having an Unusually High Single Channel Conductance Biophysical Journal. 100: 564a-565a. DOI: 10.1016/J.Bpj.2010.12.3275  0.412
2010 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66: 85-100. PMID 20399731 DOI: 10.1016/J.Neuron.2010.03.028  0.737
2010 Gamini R, Sotomayor M, Chipot C, Schulten K. The Role of MscS Cytoplasmic Domain As An Osmolyte Filter Biophysical Journal. 98: 328a. DOI: 10.1016/J.Bpj.2009.12.1778  0.784
2009 Lee EH, Hsin J, Sotomayor M, Comellas G, Schulten K. Discovery through the computational microscope. Structure (London, England : 1993). 17: 1295-306. PMID 19836330 DOI: 10.1016/J.Str.2009.09.001  0.504
2009 Khalili-Araghi F, Gumbart J, Wen PC, Sotomayor M, Tajkhorshid E, Schulten K. Molecular dynamics simulations of membrane channels and transporters. Current Opinion in Structural Biology. 19: 128-37. PMID 19345092 DOI: 10.1016/J.Sbi.2009.02.011  0.797
2009 Sotomayor M, Corey DP. Calcium Dependent Dynamics and Forced Unbinding of Cadherins Biophysical Journal. 96: 642a-643a. DOI: 10.1016/J.Bpj.2008.12.3399  0.641
2008 Vásquez V, Sotomayor M, Cordero-Morales J, Schulten K, Perozo E. A structural mechanism for MscS gating in lipid bilayers. Science (New York, N.Y.). 321: 1210-4. PMID 18755978 DOI: 10.1126/Science.1159674  0.555
2008 Vásquez V, Sotomayor M, Cortes DM, Roux B, Schulten K, Perozo E. Three-dimensional architecture of membrane-embedded MscS in the closed conformation. Journal of Molecular Biology. 378: 55-70. PMID 18343404 DOI: 10.1016/J.Jmb.2007.10.086  0.55
2008 Sotomayor M, Schulten K. The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin Biophysical Journal. 94: 4621-4633. PMID 18326636 DOI: 10.1529/Biophysj.107.125591  0.572
2008 Lim BB, Lee EH, Sotomayor M, Schulten K. Molecular basis of fibrin clot elasticity. Structure (London, England : 1993). 16: 449-59. PMID 18294856 DOI: 10.1016/J.Str.2007.12.019  0.513
2007 Sotomayor M, Schulten K. Single-molecule experiments in vitro and in silico Science. 316: 1144-1148. PMID 17525328 DOI: 10.1126/Science.1137591  0.567
2007 Sotomayor M, Vásquez V, Perozo E, Schulten K. Ion conduction through MscS as determined by electrophysiology and simulation. Biophysical Journal. 92: 886-902. PMID 17114233 DOI: 10.1529/Biophysj.106.095232  0.563
2006 Gao M, Sotomayor M, Villa E, Lee EH, Schulten K. Molecular mechanisms of cellular mechanics. Physical Chemistry Chemical Physics : Pccp. 8: 3692-706. PMID 16896432 DOI: 10.1039/B606019F  0.724
2006 Sotomayor M, Van Der Straaten TA, Ravaioli U, Schulten K. Electrostatic properties of the mechanosensitive channel of small conductance MscS Biophysical Journal. 90: 3496-3510. PMID 16513774 DOI: 10.1529/Biophysj.105.080069  0.6
2005 Sotomayor M, Corey DP, Schulten K. In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure (London, England : 1993). 13: 669-82. PMID 15837205 DOI: 10.1016/J.Str.2005.03.001  0.732
2004 Sotomayor M, Schulten K. Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS Biophysical Journal. 87: 3050-3065. PMID 15339798 DOI: 10.1529/Biophysj.104.046045  0.621
2004 Corey DP, Sotomayor M. Hearing: tightrope act. Nature. 428: 901-3. PMID 15118709 DOI: 10.1038/428901A  0.61
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