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Christian R.H. Raetz - Publications

Affiliations: 
Biochemistry Duke University School of Medicine, Durham, NC, United States 
Area:
lipid biochemistry
Website:
http://www.biochem.duke.edu/modules/biochem_raetz_lab/index.php?id=1

180 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dangkulwanich M, Raetz CRH, Williams AH. Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase. Scientific Reports. 9: 3947. PMID 30850651 DOI: 10.1038/s41598-019-40418-8  0.48
2018 Joo SH, Pemble CW, Yang EG, Raetz CRH, Chung HS. Biochemical and Structural Insights into an Fe(II)/α-Ketoglutarate/O Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO). Journal of Molecular Biology. PMID 30092253 DOI: 10.1016/j.jmb.2018.07.029  0.32
2014 Chung HS, Yang EG, Hwang D, Lee JE, Guan Z, Raetz CR. Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. Biochemical and Biophysical Research Communications. 452: 789-94. PMID 25204504 DOI: 10.1016/j.bbrc.2014.08.153  0.44
2014 Qian J, Garrett TA, Raetz CR. In vitro assembly of the outer core of the lipopolysaccharide from Escherichia coli K-12 and Salmonella typhimurium. Biochemistry. 53: 1250-62. PMID 24479701 DOI: 10.1021/bi4015665  0.8
2014 Masoudi A, Raetz CR, Zhou P, Pemble CW. Chasing acyl carrier protein through a catalytic cycle of lipid A production. Nature. 505: 422-6. PMID 24196711 DOI: 10.1038/nature12679  0.72
2013 Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, et al. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. The Journal of Biological Chemistry. 288: 35812-23. PMID 24189069 DOI: 10.1074/jbc.M113.519637  0.8
2013 Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S. Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification. Molecular Microbiology. 89: 52-64. PMID 23659637 DOI: 10.1111/mmi.12257  0.8
2013 Emptage RP, Pemble CW, York JD, Raetz CR, Zhou P. Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. Biochemistry. 52: 2280-90. PMID 23464738 DOI: 10.1021/bi400097z  0.8
2013 Gattis SG, Chung HS, Trent MS, Raetz CR. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. The Journal of Biological Chemistry. 288: 9216-25. PMID 23413030 DOI: 10.1074/jbc.M113.453324  0.8
2013 Sun W, Six DA, Reynolds CM, Chung HS, Raetz CR, Curtiss R. Pathogenicity of Yersinia pestis synthesis of 1-dephosphorylated lipid A. Infection and Immunity. 81: 1172-85. PMID 23357387 DOI: 10.1128/IAI.01403-12  0.8
2013 Zeng D, Zhao J, Chung HS, Guan Z, Raetz CR, Zhou P. Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. The Journal of Biological Chemistry. 288: 5475-86. PMID 23316051 DOI: 10.1074/jbc.M112.447607  0.8
2012 Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. LpxI structures reveal how a lipid A precursor is synthesized. Nature Structural & Molecular Biology. 19: 1132-8. PMID 23042606 DOI: 10.1038/nsmb.2393  0.8
2012 Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 151: 138-52. PMID 23021221 DOI: 10.1016/j.cell.2012.06.054  0.8
2012 Tan BK, Bogdanov M, Zhao J, Dowhan W, Raetz CR, Guan Z. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Proceedings of the National Academy of Sciences of the United States of America. 109: 16504-9. PMID 22988102 DOI: 10.1073/pnas.1212797109  0.8
2012 Llewellyn AC, Zhao J, Song F, Parvathareddy J, Xu Q, Napier BA, Laroui H, Merlin D, Bina JE, Cotter PA, Miller MA, Raetz CR, Weiss DS. NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Molecular Microbiology. 86: 611-27. PMID 22966934 DOI: 10.1111/mmi.12004  0.8
2012 Guan Z, Johnston NC, Raetz CR, Johnson EA, Goldfine H. Lipid diversity among botulinum neurotoxin-producing clostridia. Microbiology (Reading, England). 158: 2577-84. PMID 22837302 DOI: 10.1099/mic.0.060707-0  0.8
2012 Emptage RP, Daughtry KD, Pemble CW, Raetz CR. Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface. Proceedings of the National Academy of Sciences of the United States of America. 109: 12956-61. PMID 22826246 DOI: 10.1073/pnas.1206072109  0.8
2012 Kong Q, Six DA, Liu Q, Gu L, Wang S, Alamuri P, Raetz CR, Curtiss R. Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity. Infection and Immunity. 80: 3215-24. PMID 22753374 DOI: 10.1128/IAI.00123-12  0.8
2012 Six DA, Lambert B, Raetz CR, Doerrler WT. Density gradient enrichment of Escherichia coli lpxL mutants. Biochimica Et Biophysica Acta. 1821: 989-93. PMID 22554681 DOI: 10.1016/j.bbalip.2012.04.003  0.8
2012 Joo SH, Chung HS, Raetz CR, Garrett TA. Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase. Biochemistry. 51: 4322-30. PMID 22545860 DOI: 10.1021/bi3002242  0.8
2012 Gründahl JE, Guan Z, Rust S, Reunert J, Müller B, Du Chesne I, Zerres K, Rudnik-Schöneborn S, Ortiz-Brüchle N, Häusler MG, Siedlecka J, Swiezewska E, Raetz CR, Marquardt T. Life with too much polyprenol: polyprenol reductase deficiency. Molecular Genetics and Metabolism. 105: 642-51. PMID 22304929 DOI: 10.1016/j.ymgme.2011.12.017  0.8
2012 Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infection and Immunity. 80: 943-51. PMID 22215738 DOI: 10.1128/IAI.06109-11  0.8
2012 Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CRH, Ernst RK. LPS remodeling is an evolved survival strategy for bacteria (Proceedings of the National Academy of Sciences United States of America (2012) 109, (8716-8721) DOI: 10.1073/pnas.1202908109)) Proceedings of the National Academy of Sciences of the United States of America. 109: 13877. DOI: 10.1073/pnas.1212463109  0.8
2011 Kong Q, Six DA, Liu Q, Gu L, Roland KL, Raetz CR, Curtiss R. Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant. Infection and Immunity. 79: 5027-38. PMID 21930761 DOI: 10.1128/IAI.05524-11  0.8
2011 Garrett TA, Raetz CR, Son JD, Richardson TD, Bartling C, Guan Z. Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts. Biochimica Et Biophysica Acta. 1811: 827-37. PMID 21925285 DOI: 10.1016/j.bbalip.2011.08.012  0.8
2011 Haig NA, Guan Z, Li D, McMichael A, Raetz CR, Xu XN. Identification of self-lipids presented by CD1c and CD1d proteins. The Journal of Biological Chemistry. 286: 37692-701. PMID 21900247 DOI: 10.1074/jbc.M111.267948  0.8
2011 Li C, Guan Z, Liu D, Raetz CR. Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 11387-92. PMID 21709257 DOI: 10.1073/pnas.1108840108  0.44
2011 Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metabolism. 13: 690-700. PMID 21641550 DOI: 10.1016/j.cmet.2011.04.007  0.8
2011 Kong Q, Six DA, Roland KL, Liu Q, Gu L, Reynolds CM, Wang X, Raetz CR, Curtiss R. Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity. Journal of Immunology (Baltimore, Md. : 1950). 187: 412-23. PMID 21632711 DOI: 10.4049/jimmunol.1100339  0.8
2011 Nguyen BD, Cunningham D, Liang X, Chen X, Toone EJ, Raetz CR, Zhou P, Valdivia RH. Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. Proceedings of the National Academy of Sciences of the United States of America. 108: 10284-9. PMID 21628561 DOI: 10.1073/pnas.1107478108  0.8
2011 Sun W, Six D, Kuang X, Roland KL, Raetz CR, Curtiss R. A live attenuated strain of Yersinia pestis KIM as a vaccine against plague. Vaccine. 29: 2986-98. PMID 21320544 DOI: 10.1016/j.vaccine.2011.01.099  0.8
2011 Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CR, Goldfine H. Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochimica Et Biophysica Acta. 1811: 186-93. PMID 21195206 DOI: 10.1016/j.bbalip.2010.12.010  0.8
2011 Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ. Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorganic & Medicinal Chemistry. 19: 852-60. PMID 21194954 DOI: 10.1016/j.bmc.2010.12.017  0.8
2011 Lee CJ, Liang X, Chen X, Zeng D, Joo SH, Chung HS, Barb AW, Swanson SM, Nicholas RA, Li Y, Toone EJ, Raetz CR, Zhou P. Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chemistry & Biology. 18: 38-47. PMID 21167751 DOI: 10.1016/j.chembiol.2010.11.011  0.8
2011 Lu YH, Guan Z, Zhao J, Raetz CR. Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. The Journal of Biological Chemistry. 286: 5506-18. PMID 21148555 DOI: 10.1074/jbc.M110.199265  0.44
2011 Guan Z, Wang X, Raetz CR. Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium. Analytical Biochemistry. 409: 284-9. PMID 21050835 DOI: 10.1016/j.ab.2010.10.035  0.44
2011 Kong Q, Six DA, Roland KL, Liu Q, Gu L, Reynolds CM, Wang X, Raetz CRH, Curtiss R. Salmonella synthesizing 1-dephosphorylated lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity (The Journal of Immunology (2011) 187, (412-423)) Journal of Immunology. 187: 3449. DOI: 10.4049/jimmunol.1190051  0.8
2011 Sun W, Six D, Kuang X, Roland KL, Raetz CRH, Curtiss R. Corrigendum to " A live attenuated strain of Yersinia pestis as a vaccine against plague" [Vaccine 29 (2011) 2986-2998] Vaccine. 29: 5820. DOI: 10.1016/j.vaccine.2011.06.021  0.8
2010 Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, et al. A mouse macrophage lipidome. The Journal of Biological Chemistry. 285: 39976-85. PMID 20923771 DOI: 10.1074/jbc.M110.182915  0.8
2010 Kaminski L, Abu-Qarn M, Guan Z, Naparstek S, Ventura VV, Raetz CR, Hitchen PG, Dell A, Eichler J. AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein. Journal of Bacteriology. 192: 5572-9. PMID 20802039 DOI: 10.1128/JB.00705-10  0.8
2010 Ingram BO, Masoudi A, Raetz CR. Escherichia coli mutants that synthesize dephosphorylated lipid A molecules. Biochemistry. 49: 8325-37. PMID 20795687 DOI: 10.1021/bi101253s  0.8
2010 Rush JS, Matveev S, Guan Z, Raetz CR, Waechter CJ. Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells. Glycobiology. 20: 1585-93. PMID 20685834 DOI: 10.1093/glycob/cwq107  0.8
2010 Chen H, Liao D, Cain D, McLeod I, Ueda Y, Guan Z, Raetz C, Kelsoe G. Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane International Journal of Experimental Pathology. 91: 460-471. PMID 20681981 DOI: 10.1111/j.1365-2613.2010.00725.x  0.8
2010 Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, ... Raetz CR, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. Journal of Lipid Research. 51: 3299-305. PMID 20671299 DOI: 10.1194/jlr.M009449  0.8
2010 Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, ... ... Raetz CR, et al. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 142: 203-17. PMID 20637498 DOI: 10.1016/j.cell.2010.06.001  0.8
2010 Metzger LE, Raetz CR. An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis. Biochemistry. 49: 6715-26. PMID 20608695 DOI: 10.1021/bi1008744  0.8
2010 Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, ... Raetz CR, et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. Journal of Lipid Research. 51: 2785-97. PMID 20574076 DOI: 10.1194/jlr.M008748  0.8
2010 Chung HS, Raetz CR. Interchangeable domains in the Kdo transferases of Escherichia coli and Haemophilus influenzae. Biochemistry. 49: 4126-37. PMID 20394418 DOI: 10.1021/bi100343e  0.8
2010 Grabi?ska KA, Cui J, Chatterjee A, Guan Z, Raetz CR, Robbins PW, Samuelson J. Molecular characterization of the cis-prenyltransferase of Giardia lamblia. Glycobiology. 20: 824-32. PMID 20308470 DOI: 10.1093/glycob/cwq036  0.8
2010 Johnston NC, Aygun-Sunar S, Guan Z, Ribeiro AA, Daldal F, Raetz CR, Goldfine H. A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani. Journal of Lipid Research. 51: 1953-61. PMID 20173213 DOI: 10.1194/jlr.M004788  0.8
2010 Zavaleta-Pastor M, Sohlenkamp C, Gao JL, Guan Z, Zaheer R, Finan TM, Raetz CR, López-Lara IM, Geiger O. Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation. Proceedings of the National Academy of Sciences of the United States of America. 107: 302-7. PMID 20018679 DOI: 10.1073/pnas.0912930107  0.44
2010 Barb AW, Jiang L, Raetz CR, Zhou P. Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. Biomolecular Nmr Assignments. 4: 37-40. PMID 19941092 DOI: 10.1007/s12104-009-9201-5  0.8
2010 Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Molecular & Cellular Proteomics : McP. 9: 388-402. PMID 19884172 DOI: 10.1074/mcp.M900432-MCP200  0.8
2010 Wang X, Guan Z, Li Y, Raetz CRH. Application of electrospray ionization mass spectrometry to characterize glycerophospholipids in Francisella tularensis subsp. novicida International Journal of Mass Spectrometry. 293: 45-50. DOI: 10.1016/j.ijms.2010.03.015  0.44
2009 Metzger LE, Raetz CR. Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein. Biochemistry. 48: 11559-71. PMID 19883124 DOI: 10.1021/bi901750f  0.96
2009 Reynolds CM, Raetz CR. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Biochemistry. 48: 9627-40. PMID 19754149 DOI: 10.1021/bi901391g  0.8
2009 Bartling CM, Raetz CR. Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis. Biochemistry. 48: 8672-83. PMID 19655786 DOI: 10.1021/bi901025v  0.8
2009 Robins LI, Williams AH, Raetz CR. Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 48: 6191-201. PMID 19456129 DOI: 10.1021/bi900629e  0.8
2009 Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz CR. Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry. 48: 3068-77. PMID 19256534 DOI: 10.1021/bi900167q  0.8
2009 Rutten L, Mannie JP, Stead CM, Raetz CR, Reynolds CM, Bonvin AM, Tommassen JP, Egmond MR, Trent MS, Gros P. Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America. 106: 1960-4. PMID 19174515 DOI: 10.1073/pnas.0813064106  0.8
2009 Wang X, Ribeiro AA, Guan Z, Raetz CR. Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry. 48: 1162-72. PMID 19166327 DOI: 10.1021/bi802211k  0.44
2009 Song F, Guan Z, Raetz CR. Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida. Biochemistry. 48: 1173-82. PMID 19166326 DOI: 10.1021/bi802212t  0.44
2009 Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. Journal of Lipid Research. 50: S9-14. PMID 19098281 DOI: 10.1194/jlr.R800095-JLR200  0.8
2009 Garrett TA, Raetz CR, Richardson T, Kordestani R, Son JD, Rose RL. Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli. Journal of Lipid Research. 50: 1589-99. PMID 19096047 DOI: 10.1194/jlr.M800549-JLR200  0.8
2009 Karbarz MJ, Six DA, Raetz CR. Purification and characterization of the lipid A 1-phosphatase LpxE of Rhizobium leguminosarum. The Journal of Biological Chemistry. 284: 414-25. PMID 18984595 DOI: 10.1074/jbc.M808390200  0.8
2009 Raetz CR, Guan Z, Ingram BO, Six DA, Song F, Wang X, Zhao J. Discovery of new biosynthetic pathways: the lipid A story. Journal of Lipid Research. 50: S103-8. PMID 18974037 DOI: 10.1194/jlr.R800060-JLR200  0.8
2009 Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz C. Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q) Biochemistry. 48: 7776. DOI: 10.1021/bi9012066  0.8
2008 Ma B, Reynolds CM, Raetz CR. Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant. Proceedings of the National Academy of Sciences of the United States of America. 105: 13823-8. PMID 18768814 DOI: 10.1073/pnas.0807028105  0.8
2008 Six DA, Carty SM, Guan Z, Raetz CR. Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. Biochemistry. 47: 8623-37. PMID 18656959 DOI: 10.1021/bi800873n  0.8
2008 Grabi?ska KA, Ghosh SK, Guan Z, Cui J, Raetz CR, Robbins PW, Samuelson J. Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis. Eukaryotic Cell. 7: 1344-51. PMID 18552282 DOI: 10.1128/EC.00061-08  0.8
2008 Bartling CM, Raetz CR. Steady-state kinetics and mechanism of LpxD, the N-acyltransferase of lipid A biosynthesis. Biochemistry. 47: 5290-302. PMID 18422345 DOI: 10.1021/bi800240r  0.8
2008 Gibbons HS, Reynolds CM, Guan Z, Raetz CR. An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A. Biochemistry. 47: 2814-25. PMID 18254598 DOI: 10.1021/bi702457c  0.8
2008 Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/j.molcel.2007.11.026  0.8
2008 Garrett TA, Raetz CRH. Escherichia coli lipid A: A potent activator of innate immunity Carbohydrates in Chemistry and Biology. 3: 435-451. DOI: 10.1002/9783527618255.ch65  0.8
2007 Guan Z, Li S, Smith DC, Shaw WA, Raetz CR. Identification of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry. 46: 14500-13. PMID 18031065 DOI: 10.1021/bi701907g  0.44
2007 Barb AW, Jiang L, Raetz CR, Zhou P. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 18433-8. PMID 18025458 DOI: 10.1073/pnas.0709412104  0.8
2007 Sohlenkamp C, Galindo-Lagunas KA, Guan Z, Vinuesa P, Robinson S, Thomas-Oates J, Raetz CR, Geiger O. The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. Molecular Plant-Microbe Interactions : Mpmi. 20: 1421-30. PMID 17977153 DOI: 10.1094/MPMI-20-11-1421  0.44
2007 Garrett TA, Kordestani R, Raetz CR. Quantification of cardiolipin by liquid chromatography-electrospray ionization mass spectrometry. Methods in Enzymology. 433: 213-30. PMID 17954237 DOI: 10.1016/S0076-6879(07)33012-7  0.8
2007 Garrett TA, Guan Z, Raetz CR. Analysis of ubiquinones, dolichols, and dolichol diphosphate-oligosaccharides by liquid chromatography-electrospray ionization-mass spectrometry. Methods in Enzymology. 432: 117-43. PMID 17954215 DOI: 10.1016/S0076-6879(07)32005-3  0.8
2007 Yan A, Guan Z, Raetz CR. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. The Journal of Biological Chemistry. 282: 36077-89. PMID 17928292 DOI: 10.1074/jbc.M706172200  0.44
2007 Williams AH, Raetz CR. Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 104: 13543-50. PMID 17698807 DOI: 10.1073/pnas.0705833104  0.8
2007 Ward WC, Guan Z, Zucca FA, Fariello RG, Kordestani R, Zecca L, Raetz CR, Simon JD. Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain. Journal of Lipid Research. 48: 1457-62. PMID 17446624 DOI: 10.1194/jlr.C700008-JLR200  0.8
2007 Raetz CR, Reynolds CM, Trent MS, Bishop RE. Lipid A modification systems in gram-negative bacteria. Annual Review of Biochemistry. 76: 295-329. PMID 17362200 DOI: 10.1146/annurev.biochem.76.010307.145803  0.8
2007 Wang X, Ribeiro AA, Guan Z, Abraham SN, Raetz CR. Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 104: 4136-41. PMID 17360489 DOI: 10.1073/pnas.0611606104  0.8
2007 Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 46: 3793-802. PMID 17335290 DOI: 10.1021/bi6025165  0.8
2007 Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Research. 35: D527-32. PMID 17098933 DOI: 10.1093/nar/gkl838  0.8
2006 Wang X, Ribeiro AA, Guan Z, McGrath SC, Cotter RJ, Raetz CR. Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida. Biochemistry. 45: 14427-40. PMID 17128982 DOI: 10.1021/bi061767s  0.8
2006 Schaaf G, Betts L, Garrett TA, Raetz CR, Bankaitis VA. Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1156-60. PMID 17077504 DOI: 10.1107/S1744309106041728  0.8
2006 Williams AH, Immormino RM, Gewirth DT, Raetz CR. Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proceedings of the National Academy of Sciences of the United States of America. 103: 10877-82. PMID 16835299 DOI: 10.1073/pnas.0604465103  0.8
2006 Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 50: 2178-84. PMID 16723580 DOI: 10.1128/AAC.00140-06  0.8
2006 Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Raetz CR, Trent MS. An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A. The Journal of Biological Chemistry. 281: 21974-87. PMID 16704973 DOI: 10.1074/jbc.M603527200  0.8
2006 Kanjilal-Kolar S, Basu SS, Kanipes MI, Guan Z, Garrett TA, Raetz CR. Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases. The Journal of Biological Chemistry. 281: 12865-78. PMID 16497674 DOI: 10.1074/jbc.M513864200  0.8
2006 Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, et al. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Journal of Lipid Research. 47: 1097-111. PMID 16479018 DOI: 10.1194/jlr.M600027-JLR200  0.8
2006 Wang X, McGrath SC, Cotter RJ, Raetz CR. Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. The Journal of Biological Chemistry. 281: 9321-30. PMID 16467300 DOI: 10.1074/jbc.M600435200  0.8
2005 McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z, Rudolph J, Raetz CR. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry. 44: 16574-83. PMID 16342948 DOI: 10.1021/bi0518186  0.8
2005 Guan Z, Breazeale SD, Raetz CR. Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli. Analytical Biochemistry. 345: 336-9. PMID 16118008 DOI: 10.1016/j.ab.2005.07.002  0.44
2005 Murphy RC, Raetz CR, Reynolds CM, Barkley RM. Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo2-lipid A. Prostaglandins & Other Lipid Mediators. 77: 131-40. PMID 16099398 DOI: 10.1016/j.prostaglandins.2004.09.004  0.8
2005 Boon Hinckley M, Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Lauw FN, Golenbock DT, Raetz CR. A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A. The Journal of Biological Chemistry. 280: 30214-24. PMID 15994324 DOI: 10.1074/jbc.M506103200  0.8
2005 Tran AX, Lester ME, Stead CM, Raetz CR, Maskell DJ, McGrath SC, Cotter RJ, Trent MS. Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A. The Journal of Biological Chemistry. 280: 28186-94. PMID 15951433 DOI: 10.1074/jbc.M505020200  0.8
2005 Williams GJ, Breazeale SD, Raetz CR, Naismith JH. Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. The Journal of Biological Chemistry. 280: 23000-8. PMID 15809294 DOI: 10.1074/jbc.M501534200  0.8
2005 Reynolds CM, Kalb SR, Cotter RJ, Raetz CR. A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. The Journal of Biological Chemistry. 280: 21202-11. PMID 15795227 DOI: 10.1074/jbc.M500964200  0.8
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/nsmb910  0.8
2005 Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, et al. A comprehensive classification system for lipids. Journal of Lipid Research. 46: 839-61. PMID 15722563 DOI: 10.1194/jlr.E400004-JLR200  0.8
2005 Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. The Journal of Biological Chemistry. 280: 14154-67. PMID 15695810 DOI: 10.1074/jbc.M414265200  0.8
2005 Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. Biochemistry. 44: 1114-26. PMID 15667205 DOI: 10.1021/bi047820z  0.8
2005 McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. Biochemistry. 44: 1106-13. PMID 15667204 DOI: 10.1021/bi048001h  0.8
2005 Gibbons HS, Kalb SR, Cotter RJ, Raetz CR. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Molecular Microbiology. 55: 425-40. PMID 15659161 DOI: 10.1111/j.1365-2958.2004.04409.x  0.8
2005 Li X, McClerren AL, Raetz CRH, Hindsgaul O. Mapping the active site of the bacterial enzyme LpxC using novel carbohydrate-based hydroxamic acid inhibitors Journal of Carbohydrate Chemistry. 24: 583-609. DOI: 10.1081/CAR-200068781  0.8
2004 Jain NU, Wyckoff TJ, Raetz CR, Prestegard JH. Rapid analysis of large protein-protein complexes using NMR-derived orientational constraints: the 95 kDa complex of LpxA with acyl carrier protein. Journal of Molecular Biology. 343: 1379-89. PMID 15491619 DOI: 10.1016/j.jmb.2004.08.103  0.8
2004 Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS. Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. The Journal of Biological Chemistry. 279: 55780-91. PMID 15489235 DOI: 10.1074/jbc.M406480200  0.8
2004 Wang X, Karbarz MJ, McGrath SC, Cotter RJ, Raetz CR. MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli. The Journal of Biological Chemistry. 279: 49470-8. PMID 15339914 DOI: 10.1074/jbc.M409078200  0.8
2004 Doerrler WT, Gibbons HS, Raetz CR. MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli. The Journal of Biological Chemistry. 279: 45102-9. PMID 15304478 DOI: 10.1074/jbc.M408106200  0.32
2004 Sweet CR, Ribeiro AA, Raetz CR. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. The Journal of Biological Chemistry. 279: 25400-10. PMID 15044494 DOI: 10.1074/jbc.M400596200  0.8
2004 Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR. Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group. The Journal of Biological Chemistry. 279: 25411-9. PMID 15044493 DOI: 10.1074/jbc.M400597200  0.8
2004 Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR. A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2. The Journal of Biological Chemistry. 279: 25420-9. PMID 15044492 DOI: 10.1074/jbc.M400598200  0.8
2004 Coggins BE, Li X, Hindsgaul O, Raetz CR, Zhou P. Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. Journal of Biomolecular Nmr. 28: 201-2. PMID 14755169 DOI: 10.1023/B:JNMR.0000013817.29493.87  0.8
2003 Karbarz MJ, Kalb SR, Cotter RJ, Raetz CR. Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase. The Journal of Biological Chemistry. 278: 39269-79. PMID 12869541 DOI: 10.1074/jbc.M305830200  0.8
2003 Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. Nature Structural Biology. 10: 645-51. PMID 12833153 DOI: 10.1038/nsb948  0.8
2003 Breazeale SD, Ribeiro AA, Raetz CR. Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose. The Journal of Biological Chemistry. 278: 24731-9. PMID 12704196 DOI: 10.1074/jbc.M304043200  0.44
2003 Kanipes MI, Ribeiro AA, Lin S, Cotter RJ, Raetz CR. A mannosyl transferase required for lipopolysaccharide inner core assembly in Rhizobium leguminosarum. Purification, substrate specificity, and expression in Salmonella waaC mutants. The Journal of Biological Chemistry. 278: 16356-64. PMID 12591937 DOI: 10.1074/jbc.M301255200  0.44
2003 Kanipes MI, Kalb SR, Cotter RJ, Hozbor DF, Lagares A, Raetz CR. Relaxed sugar donor selectivity of a Sinorhizobium meliloti ortholog of the Rhizobium leguminosarum mannosyl transferase LpcC. Role of the lipopolysaccharide core in symbiosis of Rhizobiaceae with plants. The Journal of Biological Chemistry. 278: 16365-71. PMID 12591936 DOI: 10.1074/jbc.M301256200  0.8
2003 Li X, Uchiyama T, Raetz CR, Hindsgaul O. Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis. Organic Letters. 5: 539-41. PMID 12583763 DOI: 10.1021/ol027458l  0.8
2003 Pirrung MC, Tumey LN, McClerren AL, Raetz CR. High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties. Journal of the American Chemical Society. 125: 1575-86. PMID 12568618 DOI: 10.1021/ja0209114  0.8
2003 Que-Gewirth NL, Karbarz MJ, Kalb SR, Cotter RJ, Raetz CR. Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ. The Journal of Biological Chemistry. 278: 12120-9. PMID 12531908 DOI: 10.1074/jbc.M300379200  0.8
2003 Que-Gewirth NL, Lin S, Cotter RJ, Raetz CR. An outer membrane enzyme that generates the 2-amino-2-deoxy-gluconate moiety of Rhizobium leguminosarum lipid A. The Journal of Biological Chemistry. 278: 12109-19. PMID 12531907 DOI: 10.1074/jbc.M300378200  0.4
2002 Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. Journal of Medicinal Chemistry. 45: 4359-70. PMID 12213077 DOI: 10.1021/jm020183v  0.8
2002 Kline T, Andersen NH, Harwood EA, Bowman J, Malanda A, Endsley S, Erwin AL, Doyle M, Fong S, Harris AL, Mendelsohn B, Mdluli K, Raetz CR, Stover CK, Witte PR, et al. Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. Journal of Medicinal Chemistry. 45: 3112-29. PMID 12086497 DOI: 10.1021/jm010579r  0.8
2002 Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annual Review of Biochemistry. 71: 635-700. PMID 12045108 DOI: 10.1146/annurev.biochem.71.110601.135414  0.8
2002 Basu SS, Karbarz MJ, Raetz CR. Expression cloning and characterization of the C28 acyltransferase of lipid A biosynthesis in Rhizobium leguminosarum. The Journal of Biological Chemistry. 277: 28959-71. PMID 12019272 DOI: 10.1074/jbc.M204525200  0.8
2002 Babinski KJ, Kanjilal SJ, Raetz CR. Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. The Journal of Biological Chemistry. 277: 25947-56. PMID 12000771 DOI: 10.1074/jbc.M204068200  0.8
2002 Babinski KJ, Ribeiro AA, Raetz CR. The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis. The Journal of Biological Chemistry. 277: 25937-46. PMID 12000770 DOI: 10.1074/jbc.M204067200  0.8
2002 Sweet CR, Preston A, Toland E, Ramirez SM, Cotter RJ, Maskell DJ, Raetz CR. Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases. The Journal of Biological Chemistry. 277: 18281-90. PMID 11889134 DOI: 10.1074/jbc.M201057200  0.8
2002 Vorachek-Warren MK, Ramirez S, Cotter RJ, Raetz CR. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. The Journal of Biological Chemistry. 277: 14194-205. PMID 11830595 DOI: 10.1074/jbc.M200409200  0.8
2002 Vorachek-Warren MK, Carty SM, Lin S, Cotter RJ, Raetz CR. An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. The Journal of Biological Chemistry. 277: 14186-93. PMID 11830594 DOI: 10.1074/jbc.M200408200  0.8
2002 Breazeale SD, Ribeiro AA, Raetz CR. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. The Journal of Biological Chemistry. 277: 2886-96. PMID 11706007 DOI: 10.1074/jbc.M109377200  0.44
2001 Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CR. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. The Journal of Biological Chemistry. 276: 43132-44. PMID 11535605 DOI: 10.1074/jbc.M106962200  0.44
2001 Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR. An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. The Journal of Biological Chemistry. 276: 43122-31. PMID 11535604 DOI: 10.1074/jbc.M106961200  0.44
2001 Zhou Z, Ribeiro AA, Lin S, Cotter RJ, Miller SI, Raetz CR. Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation. The Journal of Biological Chemistry. 276: 43111-21. PMID 11535603 DOI: 10.1074/jbc.M106960200  0.44
2001 Sweet CR, Lin S, Cotter RJ, Raetz CR. A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species. The Journal of Biological Chemistry. 276: 19565-74. PMID 11279221 DOI: 10.1074/jbc.M101868200  0.8
2001 Jackman JE, Raetz CR, Fierke CA. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site. Biochemistry. 40: 514-23. PMID 11148046 DOI: 10.1021/bi001872g  0.8
2000 Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CR. Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria. The Embo Journal. 19: 5071-80. PMID 11013210 DOI: 10.1093/emboj/19.19.5071  0.8
2000 Gibbons HS, Lin S, Cotter RJ, Raetz CR. Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue. The Journal of Biological Chemistry. 275: 32940-9. PMID 10903325 DOI: 10.1074/jbc.M005779200  0.8
2000 Basu SS, Dotson GD, Raetz CRH. A facile enzymatic synthesis of uridine diphospho-[14C]galacturonic acid Analytical Biochemistry. 280: 173-177. PMID 10805536 DOI: 10.1006/abio.2000.4479  0.8
2000 Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. The Journal of Biological Chemistry. 275: 11002-9. PMID 10753902 DOI: 10.1074/jbc.275.15.11002  0.8
1999 White KA, Lin S, Cotter RJ, Raetz CRH. A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D- manno-octulosonic acid (Kdo) kinase. Possible involvement of Kdo phosphorylation in bacterial virulence Journal of Biological Chemistry. 274: 31391-31400. PMID 10531340 DOI: 10.1074/jbc.274.44.31391  0.8
1999 Basu SS, White KA, Que NLS, Raetz CRH. A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O- linked β-hydroxymyristoyl moiety of lipid A precursors Journal of Biological Chemistry. 274: 11150-11158. PMID 10196200 DOI: 10.1074/jbc.274.16.11150  0.8
1999 Basu SS, York JD, Raetz CR. A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. The Journal of Biological Chemistry. 274: 11139-49. PMID 10196199 DOI: 10.1074/jbc.274.16.11139  0.8
1999 Garrett TA, Rosser MF, Raetz CR. Signal transduction triggered by lipid A-like molecules in 70Z/3 pre-B lymphocyte tumor cells. Biochimica Et Biophysica Acta. 1437: 246-56. PMID 10064907 DOI: 10.1016/S1388-1981(99)00014-1  0.8
1999 Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su LH, Fierke CA, Jackman JE, Raetz CR, Coleman J, Tomoyasu T, Matsuzawa H. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Molecular Microbiology. 31: 833-44. PMID 10048027 DOI: 10.1046/j.1365-2958.1999.01221.x  0.8
1999 Jackman JE, Raetz CR, Fierke CA. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. Biochemistry. 38: 1902-11. PMID 10026271 DOI: 10.1021/bi982339s  0.8
1998 Wyckoff TJO, Lin S, Cotter RJ, Dotson GD, Raetz CRH. Hydrocarbon rulers in UDP-N-acetylglucosamine acyltransferases Journal of Biological Chemistry. 273: 32569-32372. PMID 9829962 DOI: 10.1074/jbc.273.49.32369  0.8
1998 Wyckoff TJ, Raetz CR, Jackman JE. Antibacterial and anti-inflammatory agents that target endotoxin. Trends in Microbiology. 6: 154-9. PMID 9587193 DOI: 10.1016/S0966-842X(98)01230-X  0.8
1998 Raetz CR. Enzymes of lipid A biosynthesis: targets for the design of new antibiotics Progress in Clinical and Biological Research. 397: 1-14. PMID 9575543  0.8
1998 Zhou Z, White KA, Polissi A, Georgopoulos C, Raetz CRH. Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis Journal of Biological Chemistry. 273: 12466-12475. PMID 9575204 DOI: 10.1074/jbc.273.20.12466  0.8
1998 Garrett TA, Que NL, Raetz CR. Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. The Journal of Biological Chemistry. 273: 12457-65. PMID 9575203 DOI: 10.1074/jbc.273.20.12457  0.8
1997 Garrett TA, Kadrmas JL, Raetz CR. Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. The Journal of Biological Chemistry. 272: 21855-64. PMID 9268317 DOI: 10.1074/jbc.272.35.21855  0.8
1997 Odegaard TJ, Kaltashov IA, Cotter RJ, Steeghs L, Van Der Ley P, Khan S, Maskell DJ, Raetz CRH. Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase Journal of Biological Chemistry. 272: 19688-19696. PMID 9242624 DOI: 10.1074/jbc.272.32.19688  0.8
1997 White KA, Kaltashov IA, Cotter RJ, Raetz CRH. A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae Journal of Biological Chemistry. 272: 16555-16563. PMID 9195966 DOI: 10.1074/jbc.272.26.16555  0.8
1997 Nichols WA, Raetz CRH, Clementz T, Smith AL, Hanson JA, Ketterer MR, Sunshine M, Apicella MA. HtrB of Haemophilus influenzae: Determination of biochemical activity and effects on virulence and lipooligosaccharide toxicity Innate Immunity. 4: 163-172. DOI: 10.1177/096805199700400301  0.8
1996 Sorensen PG, Lutkenhaus J, Young K, Eveland SS, Anderson MS, Raetz CR. Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis. The Journal of Biological Chemistry. 271: 25898-905. PMID 8824222 DOI: 10.1074/jbc.271.42.25898  0.8
1996 Clementz T, Bednarski JJ, Raetz CR. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. The Journal of Biological Chemistry. 271: 12095-102. PMID 8662613 DOI: 10.1074/jbc.271.20.12095  0.8
1995 Pfitzner U, Raetz CRH, Roderick SL. Crystallization of UDP-N-acetylglucosamine O-acyltransferase from Escherichia coli Proteins: Structure, Function and Genetics. 22: 191-192. PMID 7567967 DOI: 10.1002/prot.340220212  0.8
1995 Raetz CRH, Roderick SL. A left-handed parallel β helix in the structure of UDP-N-acetylglucosamine acyltransferase Science. 270: 997-1000. PMID 7481807 DOI: 10.1126/science.270.5238.997  0.8
1992 Hampton RY, Raetz CRH. Lipid A 4'-kinase from Escherichia coli: Enzyme assay and preparation of 4'-32P-labeled probes of high specific radioactivity Methods in Enzymology. 209: 466-475. PMID 1323052 DOI: 10.1016/0076-6879(92)09057-A  0.8
1991 Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CRH. Recognition and plasma clearance of endotoxin by scavenger receptors Nature. 352: 342-344. PMID 1852209 DOI: 10.1038/352342a0  0.8
1991 Hofer M, Hampton RY, Raetz CRH, Yu H. Aggregation behavior of lipid IVA in aqueous solutions at physiological pH. 1: Simple buffer solutions Chemistry and Physics of Lipids. 59: 167-181. PMID 1742809 DOI: 10.1016/0009-3084(91)90005-V  0.8
1988 Anderson MS, Robertson AD, Macher I, Raetz CRH. Biosynthesis of lipid A in Escherichia coli: Identification of UDP-O-[(R)-3-hydroxymyristoyl]-α-D-glucosamine as a precursor of UDP-N2,O 3-bis[(R)-3-hydroxymyristoyl]-α-D-glucosamine Biochemistry. 27: 1908-1917. PMID 3288280 DOI: 10.1021/bi00406a017  0.8
1988 Naleway JJ, Raetz CR, Anderson L. A convenient synthesis of 4-amino-4-deoxy-L-arabinose and its reduction product, 1,4-dideoxy-1,4-imino-L-arabinitol. Carbohydrate Research. 179: 199-209. PMID 3061644 DOI: 10.1016/0008-6215(88)84118-1  0.8
1988 Raetz CRH, Brozek KA, Clementz T, Coleman JD, Galloway SM, Golenbock DT, Hampton RY. Gram-negative endotoxin: A biologically active lipid Cold Spring Harbor Symposia On Quantitative Biology. 53: 973-982. PMID 2474409 DOI: 10.1101/SQB.1988.053.01.112  0.8
1987 Raetz CRH, Carman GM, Dowhan W, Jiang RT, Waszkuc W, Loffredo W, Tsai MD. Phospholipids chiral at phosphorus. Steric course of the reactions catalyzed by phosphatidylserine synthase from Escherichia coli and yeast Biochemistry. 26: 4022-4027. PMID 2820481 DOI: 10.1021/bi00387a042  0.8
1982 Raetz CR, Wermuth MM, McIntyre TM, Esko JD, Wing DC. Somatic cell cloning in polyester stacks Proceedings of the National Academy of Sciences of the United States of America. 79: 3223-3227. PMID 6954474 DOI: 10.1073/pnas.79.10.3223  0.8
1977 Raetz CR, Larson TJ, Dowhan W. Gene cloning for the isolation of enzymes of membrane lipid synthesis: phosphatidylserine synthase overproduction in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 74: 1412-1416. PMID 193099 DOI: 10.1073/pnas.74.4.1412  0.8
1977 Raetz CR, Chu MY, Srivastava S, Turcotte JG. A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue. Science (New York, N.Y.). 196: 303-5. PMID 191910 DOI: 10.1126/science.191910  0.8
1976 Raetz CR, Dowhan W, Kennedy EP. Partial purification and characterization of cytidine 5'-diphosphate-diglyceride hydrolase from membranes of Escherichia coli. Journal of Bacteriology. 125: 855-63. PMID 1254556  0.8
1976 Wickner SH, Wickner RB, Raetz CRH. Overproduction of dna gene products by Escherichia coli strains carrying hybrid co1E1 plasmids Biochemical and Biophysical Research Communications. 70: 389-396. PMID 779775 DOI: 10.1016/0006-291X(76)91058-5  0.8
1974 Raetz CR, Kennedy EP. Partial purification and properties of phosphatidylserine synthetase from Escherichia coli. The Journal of Biological Chemistry. 249: 5083-45. PMID 4604873  0.88
1973 Raetz CR, Kennedy EP. Function of cytidine diphosphate-diglyceride and deoxycytidine diphosphate-diglyceride in the biogenesis of membrane lipids in Escherichia coli. The Journal of Biological Chemistry. 248: 1098-105. PMID 4567788  0.88
1972 Raetz CRH, Auld DS. Schiff bases of pyridoxal phosphate with active center lysines of ribonuclease A Biochemistry. 11: 2229-2236. PMID 5028492 DOI: 10.1021/bi00762a004  0.8
1972 Raetz CR, Kennedy EP. The association of phosphatidylserine synthetase with ribosomes in extracts of Escherichia coli. The Journal of Biological Chemistry. 247: 2008-14. PMID 4552685  0.88
1972 Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP. A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride. The Journal of Biological Chemistry. 247: 2245-7. PMID 4335869  0.8
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