Christina D. Smolke, Ph.D. - Publications

Affiliations: 
2003-2008 California Institute of Technology, Pasadena, CA 
 2009- Bioengineering Stanford University, Palo Alto, CA 
Area:
Synthetic Biology
Website:
https://bioengineering.stanford.edu/people/christina-smolke

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Xiang JS, Kaplan M, Dykstra P, Hinks M, McKeague M, Smolke CD. Massively parallel RNA device engineering in mammalian cells with RNA-Seq. Nature Communications. 10: 4327. PMID 31548547 DOI: 10.1038/s41467-019-12334-y  0.96
2019 Kotopka BJ, Smolke CD. Production of the cyanogenic glycoside dhurrin in yeast. Metabolic Engineering Communications. 9: e00092. PMID 31110942 DOI: 10.1016/j.mec.2019.e00092  1
2019 Cravens A, Payne J, Smolke CD. Synthetic biology strategies for microbial biosynthesis of plant natural products. Nature Communications. 10: 2142. PMID 31086174 DOI: 10.1038/s41467-019-09848-w  0.88
2018 Kotopka BJ, Li Y, Smolke CD. Synthetic biology strategies toward heterologous phytochemical production. Natural Product Reports. PMID 29897091 DOI: 10.1039/c8np00028j  1
2018 Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD. Complete biosynthesis of noscapine and halogenated alkaloids in yeast. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610307 DOI: 10.1073/pnas.1721469115  1
2018 Li S, Li Y, Smolke CD. Strategies for microbial synthesis of high-value phytochemicals. Nature Chemistry. 10: 395-404. PMID 29568052 DOI: 10.1038/s41557-018-0013-z  1
2017 Wong RS, Chen YY, Smolke CD. Regulation of T cell proliferation with drug-responsive microRNA switches. Nucleic Acids Research. PMID 29244152 DOI: 10.1093/nar/gkx1228  1
2017 Wong RS, Chen YY, Smolke CD. Regulation of T cell proliferation with drug-responsive microRNA switches. Nucleic Acids Research. PMID 29244152 DOI: 10.1093/nar/gkx1228  1
2016 Mathur M, Xiang JS, Smolke CD. Mammalian synthetic biology for studying the cell. The Journal of Cell Biology. PMID 27932576 DOI: 10.1083/jcb.201611002  0.96
2016 Wang YH, McKeague M, Hsu TM, Smolke CD. Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification. Cell Systems. PMID 27840078 DOI: 10.1016/j.cels.2016.10.008  0.8
2016 McKeague M, Wang YH, Cravens A, Win MN, Smolke CD. Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines. Metabolic Engineering. PMID 27519552 DOI: 10.1016/j.ymben.2016.08.003  1
2016 Li Y, Smolke CD. Engineering biosynthesis of the anticancer alkaloid noscapine in yeast. Nature Communications. 7: 12137. PMID 27378283 DOI: 10.1038/ncomms12137  1
2016 McKeague M, Wong RS, Smolke CD. Opportunities in the design and application of RNA for gene expression control. Nucleic Acids Research. PMID 26969733 DOI: 10.1093/nar/gkw151  0.8
2015 Wei KY, Smolke CD. Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices. Journal of Biological Engineering. 9: 21. PMID 26594238 DOI: 10.1186/s13036-015-0019-7  1
2015 Galanie S, Smolke CD. Optimization of yeast-based production of medicinal protoberberine alkaloids. Microbial Cell Factories. 14: 144. PMID 26376732 DOI: 10.1186/s12934-015-0332-3  1
2015 McKeague M, Wang YH, Smolke CD. In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control. Acs Chemical Biology. PMID 26359915 DOI: 10.1021/acschembio.5b00518  1
2015 Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD. Complete biosynthesis of opioids in yeast. Science (New York, N.Y.). 349: 1095-100. PMID 26272907 DOI: 10.1126/science.aac9373  1
2015 Townshend B, Kennedy AB, Xiang JS, Smolke CD. High-throughput cellular RNA device engineering. Nature Methods. PMID 26258292 DOI: 10.1038/nmeth.3486  0.96
2015 Trenchard IJ, Siddiqui MS, Thodey K, Smolke CD. De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast. Metabolic Engineering. 31: 74-83. PMID 26166409 DOI: 10.1016/j.ymben.2015.06.010  1
2015 Bell CL, Yu D, Smolke CD, Geall AJ, Beard CW, Mason PW. Control of alphavirus-based gene expression using engineered riboswitches. Virology. 483: 302-311. PMID 26005949 DOI: 10.1016/j.virol.2015.04.023  1
2015 Trenchard IJ, Smolke CD. Engineering strategies for the fermentative production of plant alkaloids in yeast. Metabolic Engineering. 30: 96-104. PMID 25981946 DOI: 10.1016/j.ymben.2015.05.001  1
2015 Bloom RJ, Winkler SM, Smolke CD. Synthetic feedback control using an RNAi-based gene-regulatory device. Journal of Biological Engineering. 9: 5. PMID 25897323 DOI: 10.1186/s13036-015-0002-3  1
2015 Townshend B, Kennedy AB, Xiang JS, Smolke CD. High-throughput cellular RNA device engineering Nature Methods. DOI: 10.1038/nmeth.3486  0.88
2014 Chang AL, McKeague M, Smolke CD. Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance. Methods in Enzymology. 549: 451-66. PMID 25432760 DOI: 10.1016/B978-0-12-801122-5.00019-2  1
2014 Kennedy AB, Vowles JV, d'Espaux L, Smolke CD. Protein-responsive ribozyme switches in eukaryotic cells. Nucleic Acids Research. 42: 12306-21. PMID 25274734 DOI: 10.1093/nar/gku875  1
2014 Siddiqui MS, Choksi A, Smolke CD. A system for multilocus chromosomal integration and transformation-free selection marker rescue. Fems Yeast Research. 14: 1171-85. PMID 25226817 DOI: 10.1111/1567-1364.12210  1
2014 Bloom RJ, Winkler SM, Smolke CD. A quantitative framework for the forward design of synthetic miRNA circuits. Nature Methods. 11: 1147-53. PMID 25218181 DOI: 10.1038/nmeth.3100  1
2014 Thodey K, Galanie S, Smolke CD. A microbial biomanufacturing platform for natural and semisynthetic opioids. Nature Chemical Biology. 10: 837-44. PMID 25151135 DOI: 10.1038/nchembio.1613  1
2014 Michener JK, Smolke CD. Synthetic RNA switches for yeast metabolic engineering: screening recombinant enzyme libraries. Methods in Molecular Biology (Clifton, N.J.). 1152: 125-36. PMID 24744030 DOI: 10.1007/978-1-4939-0563-8_7  1
2014 Beisel CL, Bloom RJ, Smolke CD. Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing. Methods in Molecular Biology (Clifton, N.J.). 1111: 259-67. PMID 24549626 DOI: 10.1007/978-1-62703-755-6_19  1
2014 Chang AL, McKeague M, Liang JC, Smolke CD. Kinetic and equilibrium binding characterization of aptamers to small molecules using a label-free, sensitive, and scalable platform. Analytical Chemistry. 86: 3273-8. PMID 24548121 DOI: 10.1021/ac5001527  1
2013 Galloway KE, Franco E, Smolke CD. Dynamically reshaping signaling networks to program cell fate via genetic controllers. Science (New York, N.Y.). 341: 1235005. PMID 23950497 DOI: 10.1126/science.1235005  1
2013 Galanie S, Siddiqui MS, Smolke CD. Molecular tools for chemical biotechnology. Current Opinion in Biotechnology. 24: 1000-9. PMID 23528237 DOI: 10.1016/j.copbio.2013.03.001  1
2013 Wang YH, Wei KY, Smolke CD. Synthetic biology: advancing the design of diverse genetic systems. Annual Review of Chemical and Biomolecular Engineering. 4: 69-102. PMID 23413816 DOI: 10.1146/annurev-chembioeng-061312-103351  1
2013 Wei KY, Chen YY, Smolke CD. A yeast-based rapid prototype platform for gene control elements in mammalian cells. Biotechnology and Bioengineering. 110: 1201-10. PMID 23184812 DOI: 10.1002/bit.24792  1
2013 Kennedy AB, Liang JC, Smolke CD. A versatile cis-blocking and trans-activation strategy for ribozyme characterization. Nucleic Acids Research. 41: e41. PMID 23155065 DOI: 10.1093/nar/gks1036  1
2013 Siddiqui MS, Smolke CD. Production of plant alkaloids in saccharomyces cerevisiae Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 338.  0.88
2012 Michener JK, Nielsen J, Smolke CD. Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases. Proceedings of the National Academy of Sciences of the United States of America. 109: 19504-9. PMID 23129650 DOI: 10.1073/pnas.1212287109  1
2012 Liang JC, Chang AL, Kennedy AB, Smolke CD. A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity. Nucleic Acids Research. 40: e154. PMID 22810204 DOI: 10.1093/nar/gks636  1
2012 Michener JK, Smolke CD. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metabolic Engineering. 14: 306-16. PMID 22554528 DOI: 10.1016/j.ymben.2012.04.004  1
2012 Smolke CD, Tyo KE. Synthetic biology: emerging methodologies to catalyze the metabolic engineering design cycle. Metabolic Engineering. 14: 187-8. PMID 22465683 DOI: 10.1016/j.ymben.2012.03.009  1
2012 Chen YY, Galloway KE, Smolke CD. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biology. 13: 240. PMID 22348749 DOI: 10.1186/gb-2012-13-2-240  1
2012 Liang JC, Smolke CD. Rational design and tuning of ribozyme-based devices. Methods in Molecular Biology (Clifton, N.J.). 848: 439-54. PMID 22315085 DOI: 10.1007/978-1-61779-545-9_27  1
2012 Chang AL, Wolf JJ, Smolke CD. Synthetic RNA switches as a tool for temporal and spatial control over gene expression. Current Opinion in Biotechnology. 23: 679-88. PMID 22305712 DOI: 10.1016/j.copbio.2012.01.005  1
2012 Siddiqui MS, Thodey K, Trenchard I, Smolke CD. Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools. Fems Yeast Research. 12: 144-70. PMID 22136110 DOI: 10.1111/j.1567-1364.2011.00774.x  1
2012 Michener JK, Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metabolic Engineering. 14: 212-22. PMID 21946159 DOI: 10.1016/j.ymben.2011.09.004  1
2011 Chen YY, Smolke CD. From DNA to targeted therapeutics: bringing synthetic biology to the clinic. Science Translational Medicine. 3: 106ps42. PMID 22030748 DOI: 10.1126/scitranslmed.3002944  1
2011 Liang JC, Bloom RJ, Smolke CD. Engineering biological systems with synthetic RNA molecules. Molecular Cell. 43: 915-26. PMID 21925380 DOI: 10.1016/j.molcel.2011.08.023  1
2011 Thodey K, Smolke CD. Cell biology. Bringing it together with RNA. Science (New York, N.Y.). 333: 412-3. PMID 21778388 DOI: 10.1126/science.1209685  1
2011 Babiskin AH, Smolke CD. Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity. Nucleic Acids Research. 39: 8651-64. PMID 21737428 DOI: 10.1093/nar/gkr445  1
2011 Smolke CD, Silver PA. Informing biological design by integration of systems and synthetic biology. Cell. 144: 855-9. PMID 21414477 DOI: 10.1016/j.cell.2011.02.020  1
2011 Babiskin AH, Smolke CD. A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. Molecular Systems Biology. 7: 471. PMID 21364573 DOI: 10.1038/msb.2011.4  1
2011 Babiskin AH, Smolke CD. Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules. Nucleic Acids Research. 39: 5299-311. PMID 21355039 DOI: 10.1093/nar/gkr090  1
2011 Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Research. 39: 2981-94. PMID 21149259 DOI: 10.1093/nar/gkq954  1
2010 Culler SJ, Hoff KG, Smolke CD. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science (New York, N.Y.). 330: 1251-5. PMID 21109673 DOI: 10.1126/science.1192128  1
2010 Chen YY, Jensen MC, Smolke CD. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proceedings of the National Academy of Sciences of the United States of America. 107: 8531-6. PMID 20421500 DOI: 10.1073/pnas.1001721107  1
2010 Culler SJ, Hoff KG, Voelker RB, Berglund JA, Smolke CD. Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors. Nucleic Acids Research. 38: 5152-65. PMID 20385591 DOI: 10.1093/nar/gkq248  1
2010 Win MN, Liang JC, Smolke CD. Frameworks for Programming RNA Devices The Chemical Biology of Nucleic Acids. 323-338. DOI: 10.1002/9780470664001.ch15  1
2009 Hoff KG, Culler SJ, Nguyen PQ, McGuire RM, Silberg JJ, Smolke CD. In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2. Chemistry & Biology. 16: 1299-308. PMID 20064440 DOI: 10.1016/j.chembiol.2009.11.011  1
2009 Smolke CD. Building outside of the box: iGEM and the BioBricks Foundation. Nature Biotechnology. 27: 1099-102. PMID 20010584 DOI: 10.1038/nbt1209-1099  1
2009 Arkin A, Berry D, Church G, Arnold F, Boldt J, Müller O, Ellington AD, Endy D, Fussenegger M, Gold ER, Greenwood J, Lee SY, Lim W, Minshull J, Murray TH, ... ... Smolke C, et al. What's in a name? Nature Biotechnology. 27: 1071-1073. PMID 20010573 DOI: 10.1038/nbt1209-1071  1
2009 Smolke CD. Cell biology. It's the DNA that counts. Science (New York, N.Y.). 324: 1156-7. PMID 19478174 DOI: 10.1126/science.1174843  1
2009 Beisel CL, Smolke CD. Design principles for riboswitch function. Plos Computational Biology. 5: e1000363. PMID 19381267 DOI: 10.1371/journal.pcbi.1000363  1
2009 Win MN, Liang JC, Smolke CD. Frameworks for programming biological function through RNA parts and devices. Chemistry & Biology. 16: 298-310. PMID 19318211 DOI: 10.1016/j.chembiol.2009.02.011  1
2009 Hoff KG, Goodlitt R, Li R, Smolke CD, Silberg JJ. Fluorescence detection of a protein-bound 2Fe2S cluster. Chembiochem : a European Journal of Chemical Biology. 10: 667-70. PMID 19184988 DOI: 10.1002/cbic.200800747  1
2009 Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD. Synthetic control of a fitness tradeoff in yeast nitrogen metabolism. Journal of Biological Engineering. 3: 1. PMID 19118500 DOI: 10.1186/1754-1611-3-1  1
2009 Maung NW, Smolke CD. A modular and extensible RNA-based gene-regulatory platform for engineering cellular function (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 36, (14283-14288) DOI: 10.1073/pnas. 0703961104) Proceedings of the National Academy of Sciences of the United States of America. 106: 15514. DOI: 10.1073/pnas.0908785106  0.88
2008 Beisel CL, Bayer TS, Hoff KG, Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Molecular Systems Biology. 4: 224. PMID 18956013 DOI: 10.1038/msb.2008.62  1
2008 Win MN, Smolke CD. Higher-order cellular information processing with synthetic RNA devices. Science (New York, N.Y.). 322: 456-60. PMID 18927397 DOI: 10.1126/science.1160311  1
2008 Hawkins KM, Smolke CD. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nature Chemical Biology. 4: 564-73. PMID 18690217 DOI: 10.1038/nchembio.105  1
2008 Chen YY, Brown CE, Jensen MC, Smolke CD. T cell proliferation control with small molecule-responsive RNA-based regulatory systems Aiche Annual Meeting, Conference Proceedings 1
2008 Beisel CL, Smolke C. How to make an information processing device out of RNA Aiche Annual Meeting, Conference Proceedings 1
2008 Beisel CL, Smolke C. Ligand-responsive micrornas: Toward probing and programming cellular states Aiche Annual Meeting, Conference Proceedings 1
2007 Win MN, Smolke CD. RNA as a versatile and powerful platform for engineering genetic regulatory tools. Biotechnology & Genetic Engineering Reviews. 24: 311-46. PMID 18059640  1
2007 Win MN, Smolke CD. A modular and extensible RNA-based gene-regulatory platform for engineering cellular function. Proceedings of the National Academy of Sciences of the United States of America. 104: 14283-8. PMID 17709748 DOI: 10.1073/pnas.0703961104  1
2006 Win MN, Klein JS, Smolke CD. Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay. Nucleic Acids Research. 34: 5670-82. PMID 17038331 DOI: 10.1093/nar/gkl718  1
2006 Pfleger BF, Pitera DJ, Smolke CD, Keasling JD. Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nature Biotechnology. 24: 1027-32. PMID 16845378 DOI: 10.1038/nbt1226  1
2006 Baker D, Church G, Collins J, Endy D, Jacobson J, Keasling J, Modrich P, Smolke C, Weiss R. Engineering life: Building a FAB for biology Scientific American. 294: 44-51. PMID 16711359  1
2006 Hawkins KM, Smolke CD. The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 281: 13485-92. PMID 16524886 DOI: 10.1074/jbc.M512317200  1
2006 Pfleger BF, Pitera DJ, Smolke CD, Keasling JD. Combinatorial engineering of InterGenic Regions to tune expression of multiple genes in operons Aiche Annual Meeting, Conference Proceedings 1
2005 Bayer TS, Smolke CD. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23: 337-43. PMID 15723047 DOI: 10.1038/nbt1069  1
2005 Bayer TS, Smolke C. Programmable, ligand-controlled riboregulators of gene expression Aiche Annual Meeting, Conference Proceedings. 8594.  1
2005 Bayer TS, Smolke C. Digital devices for the identification and quantification of large sets of biomolecules using engineered nucleic acid sensors Aiche Annual Meeting, Conference Proceedings. 11671.  1
2002 Smolke CD, Keasling JD. Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon. Biotechnology and Bioengineering. 80: 762-76. PMID 12402322 DOI: 10.1002/bit.10434  1
2002 Smolke CD, Keasling JD. Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon. Biotechnology and Bioengineering. 78: 412-24. PMID 11948448 DOI: 10.1002/bit.10218  1
2001 Smolke CD, Khlebnikov A, Keasling JD. Effects of transcription induction homogeneity and transcript stability on expression of two genes in a constructed operon. Applied Microbiology and Biotechnology. 57: 689-96. PMID 11778879 DOI: 10.1007/s002530100812  1
2001 Smolke CD, Martin VJ, Keasling JD. Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization. Metabolic Engineering. 3: 313-21. PMID 11676567 DOI: 10.1006/mben.2001.0194  1
2000 Smolke CD, Carrier TA, Keasling JD. Coordinated, differential expression of two genes through directed mRNA cleavage and stabilization by secondary structures. Applied and Environmental Microbiology. 66: 5399-405. PMID 11097920 DOI: 10.1128/AEM.66.12.5399-5405.2000  1
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