John D. Sutherland, Ph.D. - Publications

Affiliations: 
Chemistry MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
Website:
http://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/john-sutherland/

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wu LF, Su M, Liu Z, Bjork SJ, Sutherland JD. Interstrand Aminoacyl Transfer in a tRNA Acceptor Stem-Overhang Mimic. Journal of the American Chemical Society. PMID 34283595 DOI: 10.1021/jacs.1c05746  0.539
2021 Rimmer PB, Thompson SJ, Xu J, Russell DA, Green NJ, Ritson DJ, Sutherland JD, Queloz DP. Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions. Astrobiology. PMID 34152196 DOI: 10.1089/ast.2020.2335  0.686
2020 Ritson DJ, Mojzsis SJ, Sutherland JD. Supply of phosphate to early Earth by photogeochemistry after meteoritic weathering. Nature Geoscience. 13: 344-348. PMID 32395178 DOI: 10.1038/S41561-020-0556-7  0.305
2019 Xu J, Green NJ, Gibard C, Krishnamurthy R, Sutherland JD. Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction. Nature Chemistry. PMID 30936523 DOI: 10.1038/S41557-019-0225-X  0.38
2019 Bonfio C, Caumes C, Duffy CD, Patel BH, Percivalle C, Tsanakopoulou M, Sutherland JD. Length-selective synthesis of acylglycerol-phosphates through energy-dissipative cycling. Journal of the American Chemical Society. PMID 30767518 DOI: 10.1021/Jacs.8B12331  0.33
2018 Rimmer PB, Xu J, Thompson SJ, Gillen E, Sutherland JD, Queloz D. The origin of RNA precursors on exoplanets. Science Advances. 4. PMID 33276319 DOI: 10.1126/sciadv.aar3302  0.692
2018 Mariani A, Bonfio C, Johnson CM, Sutherland JD. pH-Driven RNA strand separation under prebiotically plausible conditions. Biochemistry. PMID 30383375 DOI: 10.1021/Acs.Biochem.8B01080  0.317
2018 Rimmer PB, Xu J, Thompson SJ, Gillen E, Sutherland JD, Queloz D. The origin of RNA precursors on exoplanets. Science Advances. 4: eaar3302. PMID 30083602 DOI: 10.1126/Sciadv.Aar3302  0.706
2018 Mariani A, Russell DA, Javelle T, Sutherland JD. A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent. Journal of the American Chemical Society. PMID 29965757 DOI: 10.1021/Jacs.8B05189  0.308
2018 Ritson DJ, Battilocchio C, Ley SV, Sutherland JD. Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry. Nature Communications. 9: 1821. PMID 29739945 DOI: 10.1038/S41467-018-04147-2  0.301
2017 Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS. UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nature Chemistry. 9: 1229-1234. PMID 29168482 DOI: 10.1038/Nchem.2817  0.456
2017 Xu J, Tsanakopoulou M, Magnani CJ, Szabla R, Šponer JE, Šponer J, Góra RW, Sutherland JD. A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization. Nature Chemistry. 9: 303-309. PMID 28338689 DOI: 10.1038/Nchem.2664  0.317
2016 Liu Z, Rigger L, Rossi JC, Sutherland JD, Pascal R. Mixed Anhydride Intermediates in the Reaction of 5(4H)-Oxazolones with Phosphate Esters and Nucleotides. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27534830 DOI: 10.1002/Chem.201602697  0.379
2015 Patel BH, Percivalle C, Ritson DJ, Duffy CD, Sutherland JD. Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. Nature Chemistry. 7: 301-7. PMID 25803468 DOI: 10.1038/Nchem.2202  0.337
2014 Xu J, Duffy CD, Chan CK, Sutherland JD. Solid-phase synthesis and hybrization behavior of partially 2'/3'-O-acetylated RNA oligonucleotides. The Journal of Organic Chemistry. 79: 3311-26. PMID 24666354 DOI: 10.1021/Jo5002824  0.302
2013 Ritson DJ, Sutherland JD. Synthesis of aldehydic ribonucleotide and amino acid precursors by photoredox chemistry. Angewandte Chemie (International Ed. in English). 52: 5845-7. PMID 23610046 DOI: 10.1002/Anie.201300321  0.356
2013 Bowler FR, Chan CK, Duffy CD, Gerland B, Islam S, Powner MW, Sutherland JD, Xu J. Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation. Nature Chemistry. 5: 383-9. PMID 23609088 DOI: 10.1038/Nchem.1626  0.549
2013 Islam S, Aguilar JA, Powner MW, Nilsson M, Morris GA, Sutherland JD. Detection of potential TNA and RNA nucleoside precursors in a prebiotic mixture by pure shift diffusion-ordered NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 4586-95. PMID 23371787 DOI: 10.1002/Chem.201202649  0.536
2012 Ritson D, Sutherland JD. Prebiotic synthesis of simple sugars by photoredox systems chemistry. Nature Chemistry. 4: 895-9. PMID 23089863 DOI: 10.1038/Nchem.1467  0.326
2011 Powner MW, Sutherland JD. Prebiotic chemistry: a new modus operandi. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 2870-7. PMID 21930577 DOI: 10.1098/Rstb.2011.0134  0.301
2011 Lilley DM, Sutherland J. The chemical origins of life and its early evolution: an introduction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 2853-6. PMID 21930575 DOI: 10.1098/Rstb.2011.0133  0.348
2011 Powner MW, Sutherland JD, Szostak JW. The origins of nucleotides Synlett. 1956-1964. DOI: 10.1055/S-0030-1261177  0.536
2011 Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water (Journal of the American Chemical Society (2010) 132 (16677-16688) DOI:10.1021/ja108197s) Journal of the American Chemical Society. 133: 4149-4150. DOI: 10.1021/ja2002023  0.393
2010 Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. Journal of the American Chemical Society. 132: 16677-88. PMID 21043502 DOI: 10.1021/Ja108197S  0.578
2010 Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A stereoelectronic effect in prebiotic nucleotide synthesis. Acs Chemical Biology. 5: 655-7. PMID 20499895 DOI: 10.1021/Cb100093G  0.312
2010 Bokhove M, Yoshida H, Hensgens CM, van der Laan JM, Sutherland JD, Dijkstra BW. Structures of an isopenicillin N converting Ntn-hydrolase reveal different catalytic roles for the active site residues of precursor and mature enzyme. Structure (London, England : 1993). 18: 301-8. PMID 20223213 DOI: 10.1016/J.Str.2010.01.005  0.315
2009 Powner MW, Gerland B, Sutherland JD. Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature. 459: 239-42. PMID 19444213 DOI: 10.1038/Nature08013  0.39
2008 Anastasi C, Buchet FF, Crowe MA, Helliwell M, Raftery J, Sutherland JD. The search for a potentially prebiotic synthesis of nucleotides via arabinose-3-phosphate and its cyanamide derivative. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 2375-88. PMID 18203227 DOI: 10.1002/Chem.200701351  0.542
2008 Sutherland JD, Mullen LB, Buchet FF. Potentially prebiotic passerini-type reactions of phosphates Synlett. 2161-2163. DOI: 10.1055/S-2008-1078018  0.751
2007 Mullen LB, Sutherland JD. Simultaneous nucleotide activation and synthesis of amino acid amides by a potentially prebiotic multi-component reaction. Angewandte Chemie (International Ed. in English). 46: 8063-6. PMID 17854015 DOI: 10.1002/Anie.200702870  0.752
2007 Powner MW, Anastasi C, Crowe MA, Parkes AL, Raftery J, Sutherland JD. On the prebiotic synthesis of ribonucleotides: photoanomerisation of cytosine nucleosides and nucleotides revisited. Chembiochem : a European Journal of Chemical Biology. 8: 1170-9. PMID 17549787 DOI: 10.1002/Cbic.200700098  0.525
2007 Mullen LB, Sutherland JD. Formation of potentially prebiotic amphiphiles by reaction of beta-hydroxy-n-alkylamines with cyclotriphosphate. Angewandte Chemie (International Ed. in English). 46: 4166-8. PMID 17457789 DOI: 10.1002/Anie.200700394  0.734
2007 Anastasi C, Buchet FF, Crowe MA, Parkes AL, Powner MW, Smith JM, Sutherland JD. RNA: prebiotic product, or biotic invention? Chemistry & Biodiversity. 4: 721-39. PMID 17443885 DOI: 10.1002/Cbdv.200790060  0.516
2007 Anastasi C, Crowe MA, Sutherland JD. Two-step potentially prebiotic synthesis of alpha-d-cytidine-5'-phosphate from d-glyceraldehyde-3-phosphate. Journal of the American Chemical Society. 129: 24-5. PMID 17199270 DOI: 10.1021/Ja066495V  0.531
2006 Anastasi C, Crowe MA, Powner MW, Sutherland JD. Direct assembly of nucleoside precursors from two- and three-carbon units. Angewandte Chemie (International Ed. in English). 45: 6176-9. PMID 16917794 DOI: 10.1002/Anie.200601267  0.452
2006 Crowe MA, Sutherland JD. Reaction of cytidine nucleotides with cyanoacetylene: support for the intermediacy of nucleoside-2',3'-cyclic phosphates in the prebiotic synthesis of RNA. Chembiochem : a European Journal of Chemical Biology. 7: 951-6. PMID 16642527 DOI: 10.1002/Cbic.200600024  0.547
2005 Saewan N, Crowe MA, Helliwell M, Raftery J, Chantrapromma K, Sutherland JD. Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. 4th Communication. Further observations concerning pyrimidine nucleoside synthesis by stepwise nucleobase assembly. Chemistry & Biodiversity. 2: 66-83. PMID 17191920 DOI: 10.1002/Cbdv.200490167  0.523
2004 Borsenberger V, Crowe MA, Lehbauer J, Raftery J, Helliwell M, Bhutia K, Cox T, Sutherland JD. Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. Chemistry & Biodiversity. 1: 203-46. PMID 17191842 DOI: 10.1002/Cbdv.200490020  0.507
2004 Ace K, Sutherland JD. Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. 3rd communication. Behaviour of 5-amino-1H-imidazole-4-carbonitrile derivatives. Chemistry & Biodiversity. 1: 1678-93. PMID 17191808 DOI: 10.1002/Cbdv.200490126  0.364
2004 Smith JM, Borsenberger V, Raftery J, Sutherland JD. Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. 2nd communication. Derivation and reactivity of xylose phosphates. Chemistry & Biodiversity. 1: 1418-51. PMID 17191788 DOI: 10.1002/Cbdv.200490105  0.354
2003 Ingar AA, Luke RW, Hayter BR, Sutherland JD. Synthesis of cytidine ribonucleotides by stepwise assembly of the heterocycle on a sugar phosphate. Chembiochem : a European Journal of Chemical Biology. 4: 504-7. PMID 12794860 DOI: 10.1002/Cbic.200300554  0.407
2002 Day YS, Bacon SL, Hughes-Thomas Z, Blackburn JM, Sutherland JD. Mutational analysis of the kinetics and thermodynamics of transcription factor NF-kappaB homodimerisation. Chembiochem : a European Journal of Chemical Biology. 3: 1192-9. PMID 12465027 DOI: 10.1002/1439-7633(20021202)3:12<1192::Aid-Cbic1192>3.0.Co;2-U  0.563
2002 Culliford SJ, McCauley P, Sutherland AJ, McCairn M, Sutherland J, Blackburn J, Kozlowski RZ. A novel cell-based scintillation proximity assay for studying protein function and activity in vitro using membrane-soluble scintillants. Biochemical and Biophysical Research Communications. 296: 857-863. PMID 12200126 DOI: 10.1016/S0006-291X(02)00944-0  0.544
2001 Speight RE, Hart DJ, Sutherland JD, Blackburn JM. A new plasmid display technology for the in vitro selection of functional phenotype-genotype linked proteins. Chemistry & Biology. 8: 951-65. PMID 11590020 DOI: 10.1016/S1074-5521(01)00066-7  0.561
2001 Hart DJ, Speight RE, Sutherland JD, Blackburn JM. Analysis of the NF-kappaB p50 dimer interface by diversity screening. Journal of Molecular Biology. 310: 563-75. PMID 11439024 DOI: 10.1006/Jmbi.2001.4724  0.564
1999 Hart DJ, Speight RE, Cooper MA, Sutherland JD, Blackburn JM. The salt dependence of DNA recognition by NF-kappaB p50: a detailed kinetic analysis of the effects on affinityand specificity. Nucleic Acids Research. 27: 1063-9. PMID 9927740 DOI: 10.1093/Nar/27.4.1063  0.559
1998 Rowe CJ, Shorrock CP, Claridge TD, Sutherland JD. Analysis of the conversion of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase. Chemistry & Biology. 5: 229-39. PMID 9545433 DOI: 10.1016/S1074-5521(98)90636-6  0.315
1997 Sutherland JD, Blackburn JM. Killing two birds with one stone: a chemically plausible scheme for linked nucleic acid replication and coded peptide synthesis. Chemistry & Biology. 4: 481-8. PMID 9263634 DOI: 10.1016/S1074-5521(97)90318-5  0.581
1997 Sutherland JD, Whitfield JN. Synthesis of potentially prebiotic RNA precursors: Cytosine and guanine derivatives Tetrahedron Letters. 38: 1451-1454. DOI: 10.1016/S0040-4039(97)00055-5  0.335
1997 Sutherland JD, Whitfield JN. Prebiotic chemistry: A bioorganic perspective Tetrahedron. 53: 11493-11527. DOI: 10.1016/S0040-4020(97)00438-9  0.353
1995 Blackburn JM, Sutherland JD, Baldwin JE. A heuristic approach to the analysis of enzymic catalysis: reaction of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes. Biochemistry. 34: 7548-62. PMID 7779800 DOI: 10.1021/Bi00022A031  0.638
1995 Tobin MB, Cole SC, Miller JR, Baldwin JE, Sutherland JD. Amino-acid substitutions in the cleavage site of acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum: effect on proenzyme cleavage and activity. Gene. 162: 29-35. PMID 7557412 DOI: 10.1016/0378-1119(95)00369-H  0.456
1995 Pavey JBJ, Sutherland JD, Weaver GW, Whitfield JN. Synthesis of potentially prebiotic RNA precursors: Adenine and uracil derivatives Tetrahedron Letters. 36: 2657-2660. DOI: 10.1016/0040-4039(95)00326-8  0.326
1994 Tobin MB, Cole SC, Kovacevic S, Miller JR, Baldwin JE, Sutherland JD. Acyl-coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum: effect of amino acid substitutions at Ser227, Ser230 and Ser309 on proenzyme cleavage and activity. Fems Microbiology Letters. 121: 39-46. PMID 8082826 DOI: 10.1111/J.1574-6968.1994.Tb07073.X  0.474
1994 Baldwin JE, Chan RY, Sutherland JD. Novel stereochemical manipulations of the penicillin nucleus Tetrahedron Letters. 35: 5519-5522. DOI: 10.1016/S0040-4039(00)73540-4  0.427
1993 Aplin RT, Baldwin JE, Cole SC, Sutherland JD, Tobin MB. On the production of alpha, beta-heterodimeric acyl-coenzyme A: isopenicillin N-acyltransferase of Penicillium chrysogenum. Studies using a recombinant source. Febs Letters. 319: 166-70. PMID 8384123 DOI: 10.1016/0014-5793(93)80060-8  0.454
1993 Tobin MB, Baldwin JE, Cole SC, Miller JR, Skatrud PL, Sutherland JD. The requirement for subunit interaction in the production of Penicillium chrysogenum acyl-coenzyme A:isopenicillin N acyltransferase in Escherichia coli. Gene. 132: 199-206. PMID 8224864 DOI: 10.1016/0378-1119(93)90196-A  0.452
1993 Lewis ML, Rowe CJ, Sewald N, Sutherland JD, Wilson EJ, Wright MC. The effect of pH on the solution structure of Δ1-pyrroline-2-carboxylic acid as revealed by NMR and electrospray mass spectroscopy Bioorganic and Medicinal Chemistry Letters. 3: 1193-1196. DOI: 10.1016/S0960-894X(00)80313-3  0.474
1993 Lewis ML, Martin SL, Rowe CJ, Sutherland JD, Wilson EJ, Wright MC. Reduction of Δ1-pyrroline-2-carboxylic acid to proline by an escherichia coli proline auxotroph Bioorganic and Medicinal Chemistry Letters. 3: 1189-1192. DOI: 10.1016/S0960-894X(00)80312-1  0.327
1992 Baldwin JE, Blackburn JM, Heath RJ, Sutherland JD. High-level soluble expression and purification of deacetoxycephalosporin C/deacetylcephalosporin C synthase Bioorganic and Medicinal Chemistry Letters. 2: 663-668. DOI: 10.1016/S0960-894X(00)80386-8  0.624
1991 Baldwin JE, Martin SL, Sutherland JD. Site-specific forced misincorporation mutagenesis using modified T7 DNA polymerase. Protein Engineering. 4: 579-84. PMID 1891465 DOI: 10.1093/protein/4.5.579  0.31
1991 Baldwin JE, Blackburn JM, Sutherland JD, Wright MC. High-level soluble expression of isopenicillin N synthase isozymes in E. coli Tetrahedron. 47: 5991-6002. DOI: 10.1016/S0040-4020(01)86491-7  0.618
1990 Baldwin JE, Blackburn JM, Schofield CJ, Sutherland JD. High level expression in Escherichia coli of a fungal gene under the control of strong promoters. Fems Microbiology Letters. 56: 45-51. PMID 2185127 DOI: 10.1016/0378-1097(90)90122-7  0.339
1990 Whiteman PA, Abraham EP, Baldwin JE, Fleming MD, Schofield CJ, Sutherland JD, Willis AC. Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans. Febs Letters. 262: 342-4. PMID 2110531 DOI: 10.1016/0014-5793(90)80224-7  0.495
1988 Baldwin JE, Adlington RM, Crouch NP, Coates JB, Keeping JW, Schofield CJ, Shuttleworth WA, Sutherland JD. Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase. The Journal of Antibiotics. 41: 1694-5. PMID 3198501 DOI: 10.7164/Antibiotics.41.1694  0.573
1987 Baldwin JE, Killin SJ, Pratt AJ, Sutherland JD, Turner NJ, Crabbe MJ, Abraham EP, Willis AC. Purification and characterization of cloned isopenicillin N synthetase. The Journal of Antibiotics. 40: 652-9. PMID 3301770 DOI: 10.7164/Antibiotics.40.652  0.336
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