Daniel M. Quinn - Publications

Affiliations: 
Chemistry University of Iowa, Iowa City, IA 
Area:
reaction dynamics of hydrolytic enzymes
Website:
http://www.chem.uiowa.edu/people/daniel-m-quinn

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Quinn DM, Topczewski J, Yasapala N, Lodge A. Why is Aged Acetylcholinesterase So Difficult to Reactivate? Molecules (Basel, Switzerland). 22. PMID 28869561 DOI: 10.3390/molecules22091464  0.36
2015 Morrill JA, Topczewski JJ, Lodge AM, Yasapala N, Quinn DM. Development of quantitative structure activity relationships for the binding affinity of methoxypyridinium cations for human acetylcholinesterase. Journal of Molecular Graphics & Modelling. 62: 181-189. PMID 26454505 DOI: 10.1016/j.jmgm.2015.09.016  0.36
2013 Topczewski JJ, Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM. Reversible inhibition of human acetylcholinesterase by methoxypyridinium species. Bioorganic & Medicinal Chemistry Letters. 23: 5786-9. PMID 24076173 DOI: 10.1016/j.bmcl.2013.09.008  0.72
2013 Topczewski JJ, Quinn DM. Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents. Organic Letters. 15: 1084-7. PMID 23410111 DOI: 10.1021/ol400054m  0.72
2010 Tormos JR, Wiley KL, Wang Y, Fournier D, Masson P, Nachon F, Quinn DM. Accumulation of tetrahedral intermediates in cholinesterase catalysis: a secondary isotope effect study. Journal of the American Chemical Society. 132: 17751-9. PMID 21105647 DOI: 10.1021/ja104496q  0.72
2010 Wiley KL, Tormos JR, Quinn DM. A secondary isotope effect study of equine serum butyrylcholinesterase-catalyzed hydrolysis of acetylthiocholine. Chemico-Biological Interactions. 187: 124-7. PMID 20493178 DOI: 10.1016/j.cbi.2010.05.007  0.72
2005 Tormos JR, Wiley KL, Seravalli J, Nachon F, Masson P, Nicolet Y, Quinn DM. The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate. Journal of the American Chemical Society. 127: 14538-9. PMID 16231883 DOI: 10.1021/ja052401q  0.72
2002 Sikorski RS, Malany S, Seravalli J, Quinn DM. Computational study of substrate isotope effect probes of transition state structure for acetylcholinesterase catalysis Nukleonika. 47: S9-S12.  0.72
2000 Liang Y, Medhekar R, Brockman HL, Quinn DM, Hui DY. Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase. The Journal of Biological Chemistry. 275: 24040-6. PMID 10811659 DOI: 10.1074/jbc.M003187200  0.72
2000 Malany S, Sawai M, Sikorski RS, Seravalli J, Quinn DM, Radi? Z, Taylor P, Kronman C, Velan B, Shafferman A. Transition state structure and rate determination for the acylation stage of acetylcholinesterase catalyzed hydrolysis of (acetylthio)choline Journal of the American Chemical Society. 122: 2981-2987. DOI: 10.1021/ja9933590  0.72
2000 Quinn DM, Feaster SR, Nair HK, Baker NA, Radi? Z, Taylor P. Delineation and decomposition of energies involved in quaternary ammonium binding in the active site of acetylcholinesterase Journal of the American Chemical Society. 122: 2975-2980. DOI: 10.1021/ja9933588  0.72
1999 Malany S, Baker N, Verweyst M, Medhekar R, Quinn DM, Velan B, Kronman C, Shafferman A. Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition. Chemico-Biological Interactions. 119: 99-110. PMID 10421443 DOI: 10.1016/S0009-2797(99)00018-6  0.72
1998 Savle PS, Medhekar RA, Kelley EL, May JG, Watkins SF, Fronczek FR, Quinn DM, Gandour RD. Change in the mode of inhibition of acetylcholinesterase by (4-nitrophenyl)sulfonoxyl derivatives of conformationally constrained choline analogues. Chemical Research in Toxicology. 11: 19-25. PMID 9477222 DOI: 10.1021/tx970019o  0.72
1997 Feaster SR, Quinn DM. Mechanism-based inhibitors of mammalian cholesterol esterase. Methods in Enzymology. 286: 231-52. PMID 9309653 DOI: 10.1016/S0076-6879(97)86013-2  0.72
1997 Radi? Z, Kirchhoff PD, Quinn DM, McCammon JA, Taylor P. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin. The Journal of Biological Chemistry. 272: 23265-77. PMID 9287336 DOI: 10.1074/jbc.272.37.23265  0.72
1997 Saxena A, Maxwell DM, Quinn DM, Radi? Z, Taylor P, Doctor BP. Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning. Biochemical Pharmacology. 54: 269-74. PMID 9271331 DOI: 10.1016/S0006-2952(97)00180-9  0.72
1997 Feaster SR, Quinn DM, Barnett BL. Molecular modeling of the structures of human and rat pancreatic cholesterol esterases. Protein Science : a Publication of the Protein Society. 6: 73-9. PMID 9007978 DOI: 10.1002/pro.5560060108  0.72
1996 Feaster SR, Lee K, Baker N, Hui DY, Quinn DM. Molecular recognition by cholesterol esterase of active site ligands: structure-reactivity effects for inhibition by aryl carbamates and subsequent carbamylenzyme turnover. Biochemistry. 35: 16723-34. PMID 8988009 DOI: 10.1021/bi961677v  0.72
1996 Hosea NA, Radi? Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 35: 10995-1004. PMID 8718893 DOI: 10.1021/bi9611220  0.72
1996 Harel M, Quinn DM, Nair HK, Silman I, Sussman JL. The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase Journal of the American Chemical Society. 118: 2340-2346. DOI: 10.1021/ja952232h  0.72
1995 Ashani Y, Radi? Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P. Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. The Journal of Biological Chemistry. 270: 6370-80. PMID 7890775 DOI: 10.1074/jbc.270.11.6370  0.72
1995 Radi? Z, Quinn DM, Vellom DC, Camp S, Taylor P. Allosteric control of acetylcholinesterase catalysis by fasciculin. The Journal of Biological Chemistry. 270: 20391-9. PMID 7657613 DOI: 10.1074/jbc.270.35.20391  0.72
1994 Nair HK, Seravalli J, Arbuckle T, Quinn DM. Molecular recognition in acetylcholinesterase catalysis: free-energy correlations for substrate turnover and inhibition by trifluoro ketone transition-state analogs. Biochemistry. 33: 8566-76. PMID 8031791  0.72
1993 Shin HC, Quinn DM. A simple and efficient synthesis of fatty thioacids. Lipids. 28: 73-4. PMID 8446013 DOI: 10.1007/BF02536365  0.72
1993 Nair HK, Quinn DM. m-Alkyl, α,α,α-trifluoroacetophenones: A new class of potent transition state analog inhibitors of acetylcholinesterase Bioorganic and Medicinal Chemistry Letters. 3: 2619-2622. DOI: 10.1016/S0960-894X(01)80727-7  0.72
1993 Nair HK, Lee K, Quinn DM. m-(N,N,N,-trimethylammonio)trifluoroacetophenone: A femtomolar inhibitor of acetylcholinesterase Journal of the American Chemical Society. 115: 9939-9941.  0.72
1993 Rao M, Barlow PN, Pryor AN, Paneth P, O'Leary MH, Quinn DM, Phillip Huskey W. Nitrogen isotope effects on acetylcholinesterase-catalyzed hydrolysis of o-nitroacetanilide Journal of the American Chemical Society. 115: 11676-11681.  0.72
1993 Selwood T, Feaster SR, States MJ, Pryor AN, Quinn DM. Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters Journal of the American Chemical Society. 115: 10477-10482.  0.72
1992 Shin HC, Quinn DM. Interaction of lipoprotein lipase with p-nitrophenyl N-alkylcarbamates: kinetics, mechanism, and analogy to the acylenzyme mechanism. Biochemistry. 31: 811-8. PMID 1731939  0.72
1992 Lee BH, Stelly TC, Colucci WJ, Garcia JG, Gandour RD, Quinn DM. Inhibition of acetylcholinesterase by hemicholiniums, conformationally constrained choline analogues. Evaluation of aryl and alkyl substituents. Comparisons with choline and (3-hydroxyphenyl)trimethylammonium. Chemical Research in Toxicology. 5: 411-8. PMID 1504265  0.72
1992 Pryor AN, Selwood T, Leu LS, Andracki MA, Lee BH, Rao M, Rosenberry T, Doctor BP, Silman I, Quinn DM. Simple general acid-base catalysis of physiological acetylcholinesterase reactions Journal of the American Chemical Society. 114: 3896-3900.  0.72
1991 Sutton LD, Froelich S, Hendrickson HS, Quinn DM. Cholesterol esterase catalyzed hydrolysis of mixed micellar thiophosphatidylcholines: a possible charge-relay mechanism. Biochemistry. 30: 5888-93. PMID 2043629  0.72
1990 Acheson SA, Quinn DM. Anatomy of acetylcholinesterase catalysis: reaction dynamics analogy for human erythrocyte and electric eel enzymes. Biochimica Et Biophysica Acta. 1040: 199-205. PMID 2400771 DOI: 10.1016/0167-4838(90)90076-R  0.72
1990 Yuan W, Quinn DM, Sigler PB, Gelb MH. Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. Biochemistry. 29: 6082-94. PMID 2383571 DOI: 10.1021/BI00477A028  0.72
1990 Sutton LD, Lantz JL, Eibes T, Quinn DM. Dimensional mapping of the active site of cholesterol esterase with alkylboronic acid inhibitors. Biochimica Et Biophysica Acta. 1041: 79-82. PMID 2223850 DOI: 10.1016/0167-4838(90)90125-Y  0.72
1990 Harrison EH, Bernard DW, Scholm P, Quinn DM, Rothblat GH, Glick JM. Inhibitors of neutral cholesteryl ester hydrolase. Journal of Lipid Research. 31: 2187-93. PMID 2090712  0.72
1990 Sutton LD, Stout JS, Quinn DM. Dependence of transition-state structure on acyl chain length for cholesterol esterase catalyzed hydrolysis of lipid p-nitrophenyl esters Journal of the American Chemical Society. 112: 8398-8403.  0.72
1990 Sutton LD, Quinn DM. Modulation by organic cosolvent of microscopic compositions of virtual transition states in the acylation stage of cholesterol esterase catalyzed hydrolysis of short-chain p-nitrophenyl esters Journal of the American Chemical Society. 112: 8404-8408.  0.72
1988 Sohl J, Sutton LD, Burton DJ, Quinn DM. Haloketone transition state analog inhibitors of cholesterol esterase. Biochemical and Biophysical Research Communications. 151: 554-60. PMID 3348795 DOI: 10.1016/0006-291X(88)90630-4  0.72
1987 Hosie L, Sutton LD, Quinn DM. p-Nitrophenyl and cholesteryl-N-alkyl carbamates as inhibitors of cholesterol esterase. The Journal of Biological Chemistry. 262: 260-4. PMID 3793726  0.72
1987 Acheson SA, Barlow PN, Lee GC, Swanson ML, Quinn DM. Effect of reactivity on virtual transition-state structure for the acylation stage of acetylcholinesterase-catalyzed hydrolysis of aryl esters and anilides Journal of the American Chemical Society. 109: 246-252.  0.72
1987 Quinn DM. Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states Chemical Reviews. 87: 955-979.  0.72
1987 Acheson SA, Dedopoulou D, Quinn DM. Simple general acid-base catalysis and virtual transition states for acetylcholinesterase-catalyzed hydrolysis of phenyl esters Journal of the American Chemical Society. 109: 239-245.  0.72
1987 Barlow PN, Acheson SA, Swanson ML, Quinn DM. Acetylcholinesterase-catalyzed hydrolysis of anilides: Acylation reaction dynamics and intrinsic chemical transition-state structures Journal of the American Chemical Society. 109: 253-257.  0.72
1986 Sutton LD, Stout JS, Hosie L, Spencer PS, Quinn DM. Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes. Biochemical and Biophysical Research Communications. 134: 386-92. PMID 3947331 DOI: 10.1016/0006-291X(86)90575-9  0.72
1986 Burdette RA, Quinn DM. Interfacial reaction dynamics and acyl-enzyme mechanism for lipoprotein lipase-catalyzed hydrolysis of lipid p-nitrophenyl esters. The Journal of Biological Chemistry. 261: 12016-21. PMID 3745178  0.72
1985 Stout JS, Sutton LD, Quinn DM. Acylenzyme mechanism and solvent isotope effects for cholesterol esterase-catalyzed hydrolysis of p-nitrophenyl butyrate. Biochimica Et Biophysica Acta. 837: 6-12. PMID 4052438 DOI: 10.1016/0005-2760(85)90079-7  0.72
1985 Quinn DM. Solvent isotope effects for lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters. Biochemistry. 24: 3144-9. PMID 4027237  0.72
1985 Quinn DM. Diethyl-p-nitrophenyl phosphate: an active site titrant for lipoprotein lipase. Biochimica Et Biophysica Acta. 834: 267-71. PMID 3995064 DOI: 10.1016/0005-2760(85)90165-1  0.72
1984 Stein RL, Fujihara H, Quinn DM, Fischer G, Küllertz G, Barth A, Schowen RL. Transition-state structural features for anilide hydrolysis from β-deuterium isotope effects Journal of the American Chemical Society. 106: 1457-1461.  0.72
1984 Quinn DM, Swanson ML. Virtual transition state for the acylation step of acetylcholinesterase-catalyzed hydrolysis of o-nitrochloroacetanilide Journal of the American Chemical Society. 106: 1883-1884.  0.72
1983 Shirai K, Fitzharris TJ, Shinomiya M, Muntz HG, Harmony JA, Jackson RL, Quinn DM. Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism. Journal of Lipid Research. 24: 721-30. PMID 6688442  0.72
1983 Kovach IM, Quinn DM. β-Deuterium and β-tritium isotope effects on the distribution coefficient of carbonyl compounds for transfer from water to cyclohexane or chlorocyclohexane Journal of the American Chemical Society. 105: 1947-1950.  0.72
1982 Ihm J, Quinn DM, Busch SJ, Chataing B, Harmony JA. Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholesteryl ester between plasma lipoproteins. Journal of Lipid Research. 23: 1328-41. PMID 7161562  0.72
1982 Quinn DM, Shirai K, Jackson RL, Harmony JA. Lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters. Inhibition by apolipoprotein C-II. Biochemistry. 21: 6872-9. PMID 7159570  0.72
1982 Quinn DM. Anisotropic motion of the steroid ring system of cholesteryl esters. Calculation of carbon-13 nuclear magnetic resonance relaxation times and nuclear Overhauser enhancements and comparison with experiment. Biochemistry. 21: 3548-55. PMID 7115686  0.72
1982 Shirai K, Jackson RL, Quinn DM. Reciprocal effect of apolipoprotein C-II on the lipoprotein lipase-catalyzed hydrolysis of p-nitrophenyl butyrate and trioleoylglycerol. The Journal of Biological Chemistry. 257: 10200-3. PMID 7107600  0.72
1982 Kroon PA, Quinn DM, Cordes EH. A carbon-13 nuclear magnetic resonance study of aortic lesions and cholesteryl ester rich lipoproteins from atherosclerotic rabbits. Biochemistry. 21: 2745-53. PMID 7093219  0.72
1981 Fitzharris TJ, Quinn DM, Goh EH, Johnson JD, Kashyap ML, Srivastava LS, Jackson RL, Harmony JA. Hydrolysis of guinea pig nascent very low density lipoproteins catalyzed by lipoprotein lipase: activation by hjman apolipoprotein C-II. Journal of Lipid Research. 22: 921-33. PMID 7276752  0.72
1980 Quinn DM, Venkatasubban KS, Kise M, Schowen RL. Protonic reorganization and substrate structure in catalysis by amidohydrolases Journal of the American Chemical Society. 102: 5365-5369.  0.72
1980 Quinn DM, Elrod JP, Ardis R, Friesen P, Schowen RL. Protonic reorganization in catalysis by serine proteases: Acylation by small substrates Journal of the American Chemical Society. 102: 5358-5365.  0.72
1980 Elrod JP, Hogg JL, Quinn DM, Venkatasubban KS, Schowen RL. Protonic reorganization and substrate structure in catalysis by serine proteases Journal of the American Chemical Society. 102: 3917-3922.  0.72
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