Philip F. Hughes, Ph.D. - Publications

Pharmacology & Cancer Biology Duke University, Durham, NC 
Drug Discovery

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K. TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. Cell Death & Disease. 15: 273. PMID 38632238 DOI: 10.1038/s41419-024-06654-1  0.595
2024 Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ, Leahy JW, Fitzgerald MC, Derbyshire ER. Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell Chemical Biology. PMID 38492573 DOI: 10.1016/j.chembiol.2024.02.008  0.67
2023 Haystead T, Lee E, Cho K, Gullickson G, Hughes P, Krafsur G, Freeze R, Scarneo S. Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein. Scientific Reports. 13: 22873. PMID 38129491 DOI: 10.1038/s41598-023-49077-2  0.551
2023 Freeze R, Yang KW, Haystead T, Hughes P, Scarneo S. Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis. Pharmacology Research & Perspectives. 11: e01124. PMID 37564034 DOI: 10.1002/prp2.1124  0.574
2023 Bale S, Verma P, Yalavarthi B, Scarneo SA, Hughes PF, Amin MA, Tsou PS, Khanna D, Haystead TA, Bhattacharyya S, Varga J. Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis. Jci Insight. PMID 37306632 DOI: 10.1172/jci.insight.165358  0.548
2022 Kaneko K, Nagata H, Yang XY, Ginzel J, Hartman Z, Everitt J, Hughes P, Haystead T, Morse M, Lyerly HK, Osada T. A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity. Cancers. 14. PMID 36497243 DOI: 10.3390/cancers14235762  0.59
2022 Scarneo S, Hughes P, Freeze R, Yang K, Totzke J, Haystead T. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. Acs Chemical Biology. PMID 35234444 DOI: 10.1021/acschembio.1c00788  0.623
2021 Wang Y, Scarneo SA, Kim SH, Zhang X, Chen J, Yang KW, Hughes P, Haystead T, Nackley AG. Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. Pain. PMID 34995041 DOI: 10.1097/j.pain.0000000000002511  0.607
2021 Goswami R, Russell VS, Tu JJ, Thomas C, Hughes P, Kelly F, Langel SN, Steppe J, Palmer SM, Haystead T, Blasi M, Permar SR. Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells. Iscience. 103412. PMID 34786537 DOI: 10.1016/j.isci.2021.103412  0.63
2021 Osada T, Crosby EJ, Kaneko K, Snyder JC, Ginzel JD, Acharya CR, Yang XY, Polascik TJ, Spasojevic I, Nelson RC, Hobeika A, Hartman ZC, Neckers LM, Rogatko A, Hughes PF, et al. HSP90-specific nIR probe identifies aggressive prostate cancers: translation from preclinical models to a human phase I study. Molecular Cancer Therapeutics. PMID 34675120 DOI: 10.1158/1535-7163.MCT-21-0334  0.608
2021 Wang R, Alvarez DA, Crouch BT, Pilani A, Lam C, Zhu C, Hughes P, Katz D, Haystead T, Ramanujam N. Understanding the sources of errors in Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis. Biomedical Optics Express. 12: 2299-2311. PMID 33996230 DOI: 10.1364/BOE.418818  0.623
2020 Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Science Translational Medicine. 12. PMID 33328331 DOI: 10.1126/scitranslmed.abb5647  0.627
2020 Scarneo SA, Yang KW, Roques JR, Dai A, Eibschutz LS, Hughes P, Haystead TAJ. TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. Oncotarget. 11: 1961-1970. PMID 32523651 DOI: 10.18632/Oncotarget.27606  0.475
2020 Kaneko K, Osada T, Morse MA, Gwin WR, Ginzel JD, Snyder JC, Yang XY, Liu CX, Diniz MA, Bodoor K, Hughes PF, Haystead TA, Lyerly HK. Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors. Communications Biology. 3: 226. PMID 32385408 DOI: 10.1038/s42003-020-0956-7  0.675
2019 Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TAJ. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. The Journal of Biological Chemistry. PMID 31914413 DOI: 10.1074/Jbc.Ra119.011857  0.386
2019 Scarneo SA, Eibschutz LS, Bendele PJ, Yang KW, Totzke J, Hughes P, Fox DA, Haystead TAJ. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. Arthritis Research & Therapy. 21: 292. PMID 31847895 DOI: 10.1186/S13075-019-2073-X  0.437
2019 Crouch BT, Gallagher J, Wang R, Duer J, Hall A, Soo MS, Hughes P, Haystead T, Ramanujam N. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Scientific Reports. 9: 3461. PMID 30837677 DOI: 10.1038/S41598-019-40252-Y  0.671
2019 Liao KC, Sandall CF, Carlson DA, Ulke-Lemée A, Platnich JM, Hughes PF, Muruve DA, Haystead TAJ, MacDonald JA. Application of immobilized ATP to the study of NLRP inflammasomes. Archives of Biochemistry and Biophysics. PMID 30641048 DOI: 10.1016/J.Abb.2018.12.031  0.437
2019 Kaneko K, Osada T, Hughes PF, Haystead TA, Morse MA, Lyerly HK. Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers Cancer Research. 79: 3731-3731. DOI: 10.1158/1538-7445.Sabcs18-3731  0.519
2018 Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chemical Biology. PMID 30595530 DOI: 10.1016/J.Chembiol.2018.11.003  0.68
2018 Scarneo SA, Mansourati A, Eibschutz LS, Totzke J, Roques JR, Loiselle D, Carlson D, Hughes P, Haystead TAJ. Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. Scientific Reports. 8: 17058. PMID 30451876 DOI: 10.1038/S41598-018-35189-7  0.402
2018 Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chemical Biology. PMID 30033129 DOI: 10.1016/J.Chembiol.2018.06.006  0.443
2018 Bellaye PS, Shimbori C, Yanagihara T, Carlson DA, Hughes P, Upagupta C, Sato S, Wheildon N, Haystead T, Ask K, Kolb M. Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. The European Respiratory Journal. 51. PMID 29386344 DOI: 10.1183/13993003.00386-2017  0.611
2018 Posfai D, Eubanks AL, Keim AI, Lu KY, Wang GZ, Hughes PF, Kato N, Haystead TA, Derbyshire ER. Identification of Hsp90 inhibitors with anti-Plasmodium activity. Antimicrobial Agents and Chemotherapy. PMID 29339390 DOI: 10.1128/Aac.01799-17  0.748
2017 Crouch B, Murphy H, Belonwu S, Martinez A, Gallagher J, Hall A, Soo MS, Lee M, Hughes P, Haystead T, Ramanujam N. Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens. Scientific Reports. 7: 17487. PMID 29235516 DOI: 10.1038/S41598-017-17832-X  0.691
2017 Osada T, Kaneko K, Gwin WR, Morse MA, Hobeika A, Pogue BW, Hartman ZC, Hughes PF, Haystead T, Lyerly HK. In vivo detection of HSP90 identifies breast cancers with aggressive behavior. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28993342 DOI: 10.1158/1078-0432.Ccr-17-1453  0.666
2017 Kulkarni MM, Ratcliff AN, Bhat M, Alwarawrah Y, Hughes P, Arcos J, Loiselle D, Torrelles JB, Funderburg NT, Haystead TA, Kwiek JJ. Cellular fatty acid synthase is required for late stages of HIV-1 replication. Retrovirology. 14: 45. PMID 28962653 DOI: 10.1186/S12977-017-0368-Z  0.61
2017 Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chemical Biology. 24: 1029-1039.e7. PMID 28820959 DOI: 10.1016/J.Chembiol.2017.07.011  0.681
2017 Crowe LB, Hughes PF, Alcorta DA, Osada T, Smith AP, Totzke J, Loiselle DR, Lutz ID, Gargesha M, Roy D, Roques J, Darr D, Lyerly HK, Spector NL, Haystead TA. A fluorescent Hsp90 probe demonstrates the unique association between extracellular Hsp90 and malignancy in vivo. Acs Chemical Biology. PMID 28103010 DOI: 10.1021/Acschembio.7B00006  0.674
2017 Osada T, Kaneko K, Hartman Z, Hobeika A, Hughes P, Haystead T, Morse M, Lyerly HK. Abstract 1859: Hsp90 targeted near infrared molecular imaging to detect mammografically occult invasive lobular breast cancer Cancer Research. 77: 1859-1859. DOI: 10.1158/1538-7445.Am2017-1859  0.688
2016 Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature Communications. 7: 12037. PMID 27353360 DOI: 10.1038/Ncomms12037  0.678
2016 Alwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chemical Biology. PMID 27265747 DOI: 10.1016/J.Chembiol.2016.04.011  0.667
2016 Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. An Inducible Heat Shock Protein 70 Small Molecule Inhibitor Demonstrates Anti-Dengue Virus Activity, Validating Hsp70 as a Host Antiviral Target. Antiviral Research. PMID 27058774 DOI: 10.1016/J.Antiviral.2016.03.017  0.644
2015 Darr D, Alwarawrah Y, Hunter L, Loiselle D, Hughes P, Haystead T. Abstract 4457: Novel fatty-acid synthase inhibitor in combination with platinum-based therapy provides increased tumor killing efficacy in luminal breast murine model Cancer Research. 75: 4457-4457. DOI: 10.1158/1538-7445.Am2015-4457  0.653
2015 Alwarawrah Y, Hughes P, Safi R, McDonnell DP, Spector NL, Haystead TA. Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106 Cancer Research. 75: 2703-2703. DOI: 10.1158/1538-7445.Am2015-2703  0.492
2014 Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, et al. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59. PMID 25500222 DOI: 10.1016/J.Chembiol.2014.10.016  0.719
2013 Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, et al. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. Acs Chemical Biology. 8: 2715-23. PMID 24070067 DOI: 10.1021/Cb400407C  0.63
2013 Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA. Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells. Chemistry & Biology. 20: 1187-97. PMID 24035283 DOI: 10.1016/J.Chembiol.2013.08.004  0.703
2012 Hughes PF, Barrott JJ, Carlson DA, Loiselle DR, Speer BL, Bodoor K, Rund LA, Haystead TA. A highly selective Hsp90 affinity chromatography resin with a cleavable linker. Bioorganic & Medicinal Chemistry. 20: 3298-305. PMID 22520629 DOI: 10.1016/J.Bmc.2012.03.043  0.673
2012 Huang KH, Barta TE, Rice JW, Smith ED, Ommen AJ, Ma W, Veal JM, Fadden RP, Barabasz AF, Foley BE, Hughes PF, Hanson GJ, Markworth CJ, Silinski M, Partridge JM, et al. Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90. Bioorganic & Medicinal Chemistry Letters. 22: 2550-4. PMID 22386527 DOI: 10.1016/J.Bmcl.2012.01.137  0.48
2010 Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, et al. Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. Chemistry & Biology. 17: 686-94. PMID 20659681 DOI: 10.1016/J.Chembiol.2010.04.015  0.654
2010 HU H, JAGDMANN GEJ, HUGHES PF, NICHOLS JB. ChemInform Abstract: Two Efficient Syntheses of (.+-.)-anti-N-Benzyl-3-amino-4- hydroxyhexahydroazepine. Cheminform. 26: no-no. DOI: 10.1002/chin.199541257  0.223
2009 Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, ... ... Hughes PF, et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. Journal of Medicinal Chemistry. 52: 4288-305. PMID 19552433 DOI: 10.1021/Jm900230J  0.529
2006 Rahman MT, Fukuyama T, Ryu I, Suzuki K, Yonemura K, Hughes PF, Nokihara K. High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor Tetrahedron Letters. 47: 2703-2706. DOI: 10.1016/j.tetlet.2006.02.084  0.2
2004 Hughes PF, Graham TH, Mendoza JS. Array reactors for parallel synthesis. Journal of Combinatorial Chemistry. 6: 308-11. PMID 15132589 DOI: 10.1021/cc0499643  0.22
2003 Nara S, Tanaka R, Eishima J, Hara M, Takahashi Y, Otaki S, Foglesong RJ, Hughes PF, Turkington S, Kanda Y. Discovery and structure-activity relationships of novel piperidine inhibitors of farnesyltransferase. Journal of Medicinal Chemistry. 46: 2467-73. PMID 12773050 DOI: 10.1021/Jm020522K  0.436
2002 Lampe JW, Biggers CK, Defauw JM, Foglesong RJ, Hall SE, Heerding JM, Hollinshead SP, Hu H, Hughes PF, Jagdmann GE, Johnson MG, Lai YS, Lowden CT, Lynch MP, Mendoza JS, et al. Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits. Journal of Medicinal Chemistry. 45: 2624-43. PMID 12036372 DOI: 10.1021/Jm020018F  0.448
1996 Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total Synthesis of (-)- and (+)-Balanol(1). The Journal of Organic Chemistry. 61: 4572-4581. PMID 11667382 DOI: 10.1021/jo952280k  0.264
1996 Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total synthesis of (-)· and (+)-balanol Journal of Organic Chemistry. 61: 4572-4581.  0.215
1995 Hughes P, Clardy J. Total Synthesis of 3(S)-Carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an Unusual Amino Acid Constituent of Luzopeptin A. [Erratum to document cited in CA111:39846] The Journal of Organic Chemistry. 60: 2950-2950. DOI: 10.1021/Jo00114A061  0.366
1995 Hu H, Erik Jagdmann G, Hughes PF, Nichols JB. Two efficient syntheses of (±)-anti-N-benzyl-3-amino-4-hydroxyhexahydroazepine Tetrahedron Letters. 36: 3659-3662. DOI: 10.1016/0040-4039(95)00623-K  0.206
1994 Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total synthesis of (-)-balanol Journal of Organic Chemistry. 59: 5147-5148.  0.225
1994 Hughes PF, Smith SH, Olson JT. Two chiral syntheses of threo-3-hydroxylysine Journal of Organic Chemistry. 59: 5799-5802.  0.182
1992 Hughes P, Musser J, Conklin M, Russo R. The isolation, synthesis and characterization of an isomeric form of rapamycin Tetrahedron Letters. 33: 4739-4742. DOI: 10.1016/S0040-4039(00)61273-X  0.21
1989 Hughes P, Clardy J. Total synthesis of 3(S)-carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an unusual amino acid constituent of luzopeptin A The Journal of Organic Chemistry. 54: 3260-3264. DOI: 10.1021/Jo00275A007  0.364
1986 Montelione GT, Hughes P, Clardy J, Scheraga HA. Conformational properties of 2,4-methanoproline (2-carboxy-2,4-methanopyrrolidine) in peptides: determination of preferred peptide bond conformation in aqueous solution by proton Overhauser measurements Journal of the American Chemical Society. 108: 6765-6773. DOI: 10.1021/Ja00281A051  0.338
1982 Gibson WB, Jeffcoat AR, Turan TS, Wendt RH, Hughes PF, Twine ME. Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology. 62: 237-50. PMID 7058528 DOI: 10.1016/0041-008X(82)90122-3  0.206
1980 Jeffcoat AR, Gibson WB, Rodriguez PA, Turan TS, Hughes PF, Twine ME. Zinc pyridinethione: urinary metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology. 56: 141-54. PMID 7444962 DOI: 10.1016/0041-008X(80)90139-8  0.2
1980 Hughes P, Martin M, Clardy J. Synthesis of 2,4-methanoproline Tetrahedron Letters. 21: 4579-4580. DOI: 10.1016/0040-4039(80)80078-5  0.386
1977 Frieze DM, Hughes PF, Merrill RL, Evans SA. Structural studies of organosulfur compounds. 3. Stereochemistry and conformational distortions in trans-hexahydro-1,4-benzoxathiane S-oxides Journal of Organic Chemistry. 42: 2206-2211.  0.198
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