| Year |
Citation |
Score |
| 2023 |
Haystead T, Lee E, Cho K, Gullickson G, Hughes P, Krafsur G, Freeze R, Scarneo S. Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein. Scientific Reports. 13: 22873. PMID 38129491 DOI: 10.1038/s41598-023-49077-2 |
0.549 |
|
| 2023 |
Freeze R, Yang KW, Haystead T, Hughes P, Scarneo S. Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis. Pharmacology Research & Perspectives. 11: e01124. PMID 37564034 DOI: 10.1002/prp2.1124 |
0.573 |
|
| 2023 |
Bale S, Verma P, Yalavarthi B, Scarneo SA, Hughes PF, Amin MA, Tsou PS, Khanna D, Haystead TA, Bhattacharyya S, Varga J. Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis. Jci Insight. PMID 37306632 DOI: 10.1172/jci.insight.165358 |
0.548 |
|
| 2022 |
Kaneko K, Nagata H, Yang XY, Ginzel J, Hartman Z, Everitt J, Hughes P, Haystead T, Morse M, Lyerly HK, Osada T. A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity. Cancers. 14. PMID 36497243 DOI: 10.3390/cancers14235762 |
0.591 |
|
| 2022 |
Scarneo S, Hughes P, Freeze R, Yang K, Totzke J, Haystead T. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. Acs Chemical Biology. PMID 35234444 DOI: 10.1021/acschembio.1c00788 |
0.622 |
|
| 2021 |
Wang Y, Scarneo SA, Kim SH, Zhang X, Chen J, Yang KW, Hughes P, Haystead T, Nackley AG. Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. Pain. PMID 34995041 DOI: 10.1097/j.pain.0000000000002511 |
0.606 |
|
| 2021 |
Goswami R, Russell VS, Tu JJ, Thomas C, Hughes P, Kelly F, Langel SN, Steppe J, Palmer SM, Haystead T, Blasi M, Permar SR. Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells. Iscience. 103412. PMID 34786537 DOI: 10.1016/j.isci.2021.103412 |
0.629 |
|
| 2021 |
Osada T, Crosby EJ, Kaneko K, Snyder JC, Ginzel JD, Acharya CR, Yang XY, Polascik TJ, Spasojevic I, Nelson RC, Hobeika A, Hartman ZC, Neckers LM, Rogatko A, Hughes PF, et al. HSP90-specific nIR probe identifies aggressive prostate cancers: translation from preclinical models to a human phase I study. Molecular Cancer Therapeutics. PMID 34675120 DOI: 10.1158/1535-7163.MCT-21-0334 |
0.607 |
|
| 2021 |
Wang R, Alvarez DA, Crouch BT, Pilani A, Lam C, Zhu C, Hughes P, Katz D, Haystead T, Ramanujam N. Understanding the sources of errors in Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis. Biomedical Optics Express. 12: 2299-2311. PMID 33996230 DOI: 10.1364/BOE.418818 |
0.622 |
|
| 2020 |
Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Science Translational Medicine. 12. PMID 33328331 DOI: 10.1126/scitranslmed.abb5647 |
0.626 |
|
| 2020 |
Scarneo SA, Yang KW, Roques JR, Dai A, Eibschutz LS, Hughes P, Haystead TAJ. TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. Oncotarget. 11: 1961-1970. PMID 32523651 DOI: 10.18632/Oncotarget.27606 |
0.473 |
|
| 2020 |
Kaneko K, Osada T, Morse MA, Gwin WR, Ginzel JD, Snyder JC, Yang XY, Liu CX, Diniz MA, Bodoor K, Hughes PF, Haystead TA, Lyerly HK. Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors. Communications Biology. 3: 226. PMID 32385408 DOI: 10.1038/s42003-020-0956-7 |
0.675 |
|
| 2019 |
Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TAJ. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. The Journal of Biological Chemistry. PMID 31914413 DOI: 10.1074/Jbc.Ra119.011857 |
0.378 |
|
| 2019 |
Scarneo SA, Eibschutz LS, Bendele PJ, Yang KW, Totzke J, Hughes P, Fox DA, Haystead TAJ. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. Arthritis Research & Therapy. 21: 292. PMID 31847895 DOI: 10.1186/S13075-019-2073-X |
0.434 |
|
| 2019 |
Crouch BT, Gallagher J, Wang R, Duer J, Hall A, Soo MS, Hughes P, Haystead T, Ramanujam N. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Scientific Reports. 9: 3461. PMID 30837677 DOI: 10.1038/S41598-019-40252-Y |
0.671 |
|
| 2019 |
Liao KC, Sandall CF, Carlson DA, Ulke-Lemée A, Platnich JM, Hughes PF, Muruve DA, Haystead TAJ, MacDonald JA. Application of immobilized ATP to the study of NLRP inflammasomes. Archives of Biochemistry and Biophysics. PMID 30641048 DOI: 10.1016/J.Abb.2018.12.031 |
0.433 |
|
| 2019 |
Kaneko K, Osada T, Hughes PF, Haystead TA, Morse MA, Lyerly HK. Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers Cancer Research. 79: 3731-3731. DOI: 10.1158/1538-7445.Sabcs18-3731 |
0.521 |
|
| 2018 |
Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chemical Biology. PMID 30595530 DOI: 10.1016/J.Chembiol.2018.11.003 |
0.677 |
|
| 2018 |
Scarneo SA, Mansourati A, Eibschutz LS, Totzke J, Roques JR, Loiselle D, Carlson D, Hughes P, Haystead TAJ. Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. Scientific Reports. 8: 17058. PMID 30451876 DOI: 10.1038/S41598-018-35189-7 |
0.398 |
|
| 2018 |
Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chemical Biology. PMID 30033129 DOI: 10.1016/J.Chembiol.2018.06.006 |
0.439 |
|
| 2018 |
Bellaye PS, Shimbori C, Yanagihara T, Carlson DA, Hughes P, Upagupta C, Sato S, Wheildon N, Haystead T, Ask K, Kolb M. Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. The European Respiratory Journal. 51. PMID 29386344 DOI: 10.1183/13993003.00386-2017 |
0.61 |
|
| 2018 |
Posfai D, Eubanks AL, Keim AI, Lu KY, Wang GZ, Hughes PF, Kato N, Haystead TA, Derbyshire ER. Identification of Hsp90 inhibitors with anti-Plasmodium activity. Antimicrobial Agents and Chemotherapy. PMID 29339390 DOI: 10.1128/Aac.01799-17 |
0.744 |
|
| 2017 |
Crouch B, Murphy H, Belonwu S, Martinez A, Gallagher J, Hall A, Soo MS, Lee M, Hughes P, Haystead T, Ramanujam N. Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens. Scientific Reports. 7: 17487. PMID 29235516 DOI: 10.1038/S41598-017-17832-X |
0.691 |
|
| 2017 |
Osada T, Kaneko K, Gwin WR, Morse MA, Hobeika A, Pogue BW, Hartman ZC, Hughes PF, Haystead T, Lyerly HK. In vivo detection of HSP90 identifies breast cancers with aggressive behavior. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28993342 DOI: 10.1158/1078-0432.Ccr-17-1453 |
0.665 |
|
| 2017 |
Kulkarni MM, Ratcliff AN, Bhat M, Alwarawrah Y, Hughes P, Arcos J, Loiselle D, Torrelles JB, Funderburg NT, Haystead TA, Kwiek JJ. Cellular fatty acid synthase is required for late stages of HIV-1 replication. Retrovirology. 14: 45. PMID 28962653 DOI: 10.1186/S12977-017-0368-Z |
0.609 |
|
| 2017 |
Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chemical Biology. 24: 1029-1039.e7. PMID 28820959 DOI: 10.1016/J.Chembiol.2017.07.011 |
0.681 |
|
| 2017 |
Crowe LB, Hughes PF, Alcorta DA, Osada T, Smith AP, Totzke J, Loiselle DR, Lutz ID, Gargesha M, Roy D, Roques J, Darr D, Lyerly HK, Spector NL, Haystead TA. A fluorescent Hsp90 probe demonstrates the unique association between extracellular Hsp90 and malignancy in vivo. Acs Chemical Biology. PMID 28103010 DOI: 10.1021/Acschembio.7B00006 |
0.675 |
|
| 2017 |
Osada T, Kaneko K, Hartman Z, Hobeika A, Hughes P, Haystead T, Morse M, Lyerly HK. Abstract 1859: Hsp90 targeted near infrared molecular imaging to detect mammografically occult invasive lobular breast cancer Cancer Research. 77: 1859-1859. DOI: 10.1158/1538-7445.Am2017-1859 |
0.687 |
|
| 2016 |
Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature Communications. 7: 12037. PMID 27353360 DOI: 10.1038/Ncomms12037 |
0.675 |
|
| 2016 |
Alwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chemical Biology. PMID 27265747 DOI: 10.1016/J.Chembiol.2016.04.011 |
0.667 |
|
| 2016 |
Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. An Inducible Heat Shock Protein 70 Small Molecule Inhibitor Demonstrates Anti-Dengue Virus Activity, Validating Hsp70 as a Host Antiviral Target. Antiviral Research. PMID 27058774 DOI: 10.1016/J.Antiviral.2016.03.017 |
0.641 |
|
| 2015 |
Darr D, Alwarawrah Y, Hunter L, Loiselle D, Hughes P, Haystead T. Abstract 4457: Novel fatty-acid synthase inhibitor in combination with platinum-based therapy provides increased tumor killing efficacy in luminal breast murine model Cancer Research. 75: 4457-4457. DOI: 10.1158/1538-7445.Am2015-4457 |
0.654 |
|
| 2015 |
Alwarawrah Y, Hughes P, Safi R, McDonnell DP, Spector NL, Haystead TA. Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106 Cancer Research. 75: 2703-2703. DOI: 10.1158/1538-7445.Am2015-2703 |
0.488 |
|
| 2014 |
Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, et al. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59. PMID 25500222 DOI: 10.1016/J.Chembiol.2014.10.016 |
0.716 |
|
| 2013 |
Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, et al. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. Acs Chemical Biology. 8: 2715-23. PMID 24070067 DOI: 10.1021/Cb400407C |
0.628 |
|
| 2013 |
Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA. Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells. Chemistry & Biology. 20: 1187-97. PMID 24035283 DOI: 10.1016/J.Chembiol.2013.08.004 |
0.703 |
|
| 2012 |
Hughes PF, Barrott JJ, Carlson DA, Loiselle DR, Speer BL, Bodoor K, Rund LA, Haystead TA. A highly selective Hsp90 affinity chromatography resin with a cleavable linker. Bioorganic & Medicinal Chemistry. 20: 3298-305. PMID 22520629 DOI: 10.1016/J.Bmc.2012.03.043 |
0.67 |
|
| 2012 |
Huang KH, Barta TE, Rice JW, Smith ED, Ommen AJ, Ma W, Veal JM, Fadden RP, Barabasz AF, Foley BE, Hughes PF, Hanson GJ, Markworth CJ, Silinski M, Partridge JM, et al. Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90. Bioorganic & Medicinal Chemistry Letters. 22: 2550-4. PMID 22386527 DOI: 10.1016/J.Bmcl.2012.01.137 |
0.477 |
|
| 2010 |
Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, et al. Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. Chemistry & Biology. 17: 686-94. PMID 20659681 DOI: 10.1016/J.Chembiol.2010.04.015 |
0.651 |
|
| 2010 |
HU H, JAGDMANN GEJ, HUGHES PF, NICHOLS JB. ChemInform Abstract: Two Efficient Syntheses of (.+-.)-anti-N-Benzyl-3-amino-4- hydroxyhexahydroazepine. Cheminform. 26: no-no. DOI: 10.1002/chin.199541257 |
0.224 |
|
| 2009 |
Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, ... ... Hughes PF, et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. Journal of Medicinal Chemistry. 52: 4288-305. PMID 19552433 DOI: 10.1021/Jm900230J |
0.525 |
|
| 2006 |
Rahman MT, Fukuyama T, Ryu I, Suzuki K, Yonemura K, Hughes PF, Nokihara K. High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor Tetrahedron Letters. 47: 2703-2706. DOI: 10.1016/j.tetlet.2006.02.084 |
0.201 |
|
| 2004 |
Hughes PF, Graham TH, Mendoza JS. Array reactors for parallel synthesis. Journal of Combinatorial Chemistry. 6: 308-11. PMID 15132589 DOI: 10.1021/cc0499643 |
0.222 |
|
| 2003 |
Nara S, Tanaka R, Eishima J, Hara M, Takahashi Y, Otaki S, Foglesong RJ, Hughes PF, Turkington S, Kanda Y. Discovery and structure-activity relationships of novel piperidine inhibitors of farnesyltransferase. Journal of Medicinal Chemistry. 46: 2467-73. PMID 12773050 DOI: 10.1021/Jm020522K |
0.433 |
|
| 2002 |
Lampe JW, Biggers CK, Defauw JM, Foglesong RJ, Hall SE, Heerding JM, Hollinshead SP, Hu H, Hughes PF, Jagdmann GE, Johnson MG, Lai YS, Lowden CT, Lynch MP, Mendoza JS, et al. Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits. Journal of Medicinal Chemistry. 45: 2624-43. PMID 12036372 DOI: 10.1021/Jm020018F |
0.443 |
|
| 1996 |
Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total Synthesis of (-)- and (+)-Balanol(1). The Journal of Organic Chemistry. 61: 4572-4581. PMID 11667382 DOI: 10.1021/jo952280k |
0.263 |
|
| 1996 |
Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total synthesis of (-)· and (+)-balanol Journal of Organic Chemistry. 61: 4572-4581. |
0.216 |
|
| 1995 |
Hughes P, Clardy J. Total Synthesis of 3(S)-Carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an Unusual Amino Acid Constituent of Luzopeptin A. [Erratum to document cited in CA111:39846] The Journal of Organic Chemistry. 60: 2950-2950. DOI: 10.1021/Jo00114A061 |
0.366 |
|
| 1995 |
Hu H, Erik Jagdmann G, Hughes PF, Nichols JB. Two efficient syntheses of (±)-anti-N-benzyl-3-amino-4-hydroxyhexahydroazepine Tetrahedron Letters. 36: 3659-3662. DOI: 10.1016/0040-4039(95)00623-K |
0.207 |
|
| 1994 |
Lampe JW, Hughes PF, Biggers CK, Smith SH, Hu H. Total synthesis of (-)-balanol Journal of Organic Chemistry. 59: 5147-5148. |
0.226 |
|
| 1994 |
Hughes PF, Smith SH, Olson JT. Two chiral syntheses of threo-3-hydroxylysine Journal of Organic Chemistry. 59: 5799-5802. |
0.183 |
|
| 1992 |
Hughes P, Musser J, Conklin M, Russo R. The isolation, synthesis and characterization of an isomeric form of rapamycin Tetrahedron Letters. 33: 4739-4742. DOI: 10.1016/S0040-4039(00)61273-X |
0.211 |
|
| 1989 |
Hughes P, Clardy J. Total synthesis of 3(S)-carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an unusual amino acid constituent of luzopeptin A The Journal of Organic Chemistry. 54: 3260-3264. DOI: 10.1021/Jo00275A007 |
0.364 |
|
| 1986 |
Montelione GT, Hughes P, Clardy J, Scheraga HA. Conformational properties of 2,4-methanoproline (2-carboxy-2,4-methanopyrrolidine) in peptides: determination of preferred peptide bond conformation in aqueous solution by proton Overhauser measurements Journal of the American Chemical Society. 108: 6765-6773. DOI: 10.1021/Ja00281A051 |
0.338 |
|
| 1982 |
Gibson WB, Jeffcoat AR, Turan TS, Wendt RH, Hughes PF, Twine ME. Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology. 62: 237-50. PMID 7058528 DOI: 10.1016/0041-008X(82)90122-3 |
0.207 |
|
| 1980 |
Jeffcoat AR, Gibson WB, Rodriguez PA, Turan TS, Hughes PF, Twine ME. Zinc pyridinethione: urinary metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology. 56: 141-54. PMID 7444962 DOI: 10.1016/0041-008X(80)90139-8 |
0.201 |
|
| 1980 |
Hughes P, Martin M, Clardy J. Synthesis of 2,4-methanoproline Tetrahedron Letters. 21: 4579-4580. DOI: 10.1016/0040-4039(80)80078-5 |
0.387 |
|
| 1977 |
Frieze DM, Hughes PF, Merrill RL, Evans SA. Structural studies of organosulfur compounds. 3. Stereochemistry and conformational distortions in trans-hexahydro-1,4-benzoxathiane S-oxides Journal of Organic Chemistry. 42: 2206-2211. |
0.198 |
|
| Show low-probability matches. |