| Year |
Citation |
Score |
| 2022 |
Truax NJ, Ayinde S, Liu JO, Romo D. Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy. Journal of the American Chemical Society. PMID 36166374 DOI: 10.1021/jacs.2c08245 |
0.465 |
|
| 2022 |
Chaheine CM, Song CJ, Gladen PT, Romo D. Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-()-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 98: 194-226. PMID 36090506 DOI: 10.15227/orgsyn.098.0194 |
0.309 |
|
| 2021 |
Kiledal SA, Jourdain R, Vellalath S, Romo D. Multicomponent Enantioselective Synthesis of Tetrahydropyridazinones Employing Chiral α,β-Unsaturated Acylammonium Salts. Organic Letters. 23: 6622-6627. PMID 34436913 DOI: 10.1021/acs.orglett.1c02044 |
0.341 |
|
| 2020 |
Chaheine CM, Gladen PT, Abbasov ME, Romo D. Enantioselective, Organocatalytic Strategy for the Oxazolomycin Core: Formal Synthesis of (+)-Neooxazolomycin. Organic Letters. PMID 33226820 DOI: 10.1021/acs.orglett.0c03511 |
0.816 |
|
| 2020 |
Truax NJ, Romo D. Bridging the gap between natural product synthesis and drug discovery. Natural Product Reports. PMID 33104139 DOI: 10.1039/d0np00048e |
0.36 |
|
| 2020 |
Rao Kovvuri VR, Xue H, Romo D. Generation and Reactivity of 2-Amido-1,3-diaminoallyl Cations: Cyclic Guanidine Annulations via Net (3 + 2) and (4 + 3) Cycloadditions. Organic Letters. PMID 32009413 DOI: 10.1021/acs.orglett.0c00019 |
0.332 |
|
| 2020 |
Kommaraju SS, Aulicino J, Gobbooru S, Li J, Zhu M, Romo D, Low WK. Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA). Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 32008367 DOI: 10.1139/Bcb-2019-0307 |
0.319 |
|
| 2019 |
Truax NJ, Ayinde S, Van K, Liu JO, Romo D. Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Natural Product Tricyclic Cores. Organic Letters. PMID 31498642 DOI: 10.1021/Acs.Orglett.9B02713 |
0.432 |
|
| 2019 |
Alvariño R, Alonso E, Abbasov ME, Chaheine CM, Conner ML, Romo D, Alfonso A, Botana LM. Gracilin A derivatives target early events in Alzheimer's disease: effects on neuroinflammation and oxidative stress. Acs Chemical Neuroscience. PMID 31387354 DOI: 10.1021/Acschemneuro.9B00329 |
0.766 |
|
| 2019 |
Abbasov ME, Alvariño R, Chaheine CM, Alonso E, Sánchez JA, Conner ML, Alfonso A, Jaspars M, Botana LM, Romo D. Simplified immunosuppressive and neuroprotective agents based on gracilin A. Nature Chemistry. 11: 342-350. PMID 30903037 DOI: 10.1038/S41557-019-0230-0 |
0.809 |
|
| 2019 |
Chen R, Zhu M, Chaudhari RR, Robles O, Chen Y, Skillern W, Qin Q, Wierda WG, Zhang S, Hull KG, Romo D, Plunkett W. Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia. Leukemia. PMID 30700841 DOI: 10.1038/S41375-018-0364-X |
0.34 |
|
| 2018 |
Groll M, Nguyen H, Vellalath S, Romo D. (-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study. Marine Drugs. 16. PMID 30029468 DOI: 10.3390/Md16070240 |
0.579 |
|
| 2018 |
Romo D. Enantioselective Synthesis of Medium-Sized Lactams Employing Chiral Alpha,Beta-Unsaturated Acylammonium Salts. Angewandte Chemie (International Ed. in English). PMID 29624841 DOI: 10.1002/anie.201802483 |
0.323 |
|
| 2018 |
Kang G, Yamagami M, Vellalath S, Romo D. Enantioselective Synthesis of Medium‐Sized Lactams via Chiral α,β‐Unsaturated Acylammonium Salts Angewandte Chemie. 130: 6637-6641. DOI: 10.1002/ange.201802483 |
0.303 |
|
| 2017 |
Van KN, Romo D. Multicomponent, Enantioselective Michael-Michael-Aldol-β-Lactonizations Delivering Complex β-Lactones. The Journal of Organic Chemistry. PMID 29219311 DOI: 10.1021/acs.joc.7b02543 |
0.305 |
|
| 2017 |
Wright MH, Tao Y, Drechsel J, Krysiak J, Chamni S, Weigert-Munoz A, Harvey NL, Romo D, Sieber SA. Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells. Chemical Communications (Cambridge, England). PMID 29143030 DOI: 10.1039/C7Cc04990K |
0.69 |
|
| 2017 |
Kong W, Romo D. Diastereo- and Enantioselective Synthesis of Bi- and Tricyclic N-Heterocycle-Fused β-Lactones. The Journal of Organic Chemistry. PMID 29125760 DOI: 10.1021/acs.joc.7b02235 |
0.313 |
|
| 2017 |
Abbasov ME, Hudson BM, Tantillo DJ, Romo D. Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application. Chemical Science. 8: 1511-1524. PMID 28616147 DOI: 10.1039/C6Sc04273B |
0.803 |
|
| 2017 |
McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, et al. Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chemical Biology. PMID 28457705 DOI: 10.1016/J.Chembiol.2017.04.006 |
0.322 |
|
| 2017 |
Abbasov ME, Hudson BM, Kong W, Tantillo DJ, Romo D. Enantioselective Diels-Alder-lactamization organocascades employing a furan-based diene. Organic & Biomolecular Chemistry. PMID 28358148 DOI: 10.1039/C6Ob02738E |
0.825 |
|
| 2017 |
Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, ... ... Romo D, et al. A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorganic & Medicinal Chemistry. PMID 28236510 DOI: 10.1016/J.Bmc.2017.01.020 |
0.461 |
|
| 2016 |
Vellalath S, Romo D. Asymmetric Organocatalysis: The Emerging Utility of α,β-Unsaturated Acylammonium Salts. Angewandte Chemie (International Ed. in English). PMID 27650693 DOI: 10.1002/anie.201602217 |
0.345 |
|
| 2016 |
Bigley AN, Xiang DF, Ren Z, Xue H, Hull KG, Romo D, Raushel FM. Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants. Journal of the American Chemical Society. PMID 26907457 DOI: 10.1021/Jacs.5B12739 |
0.302 |
|
| 2015 |
He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO. Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angewandte Chemie (International Ed. in English). 54: 1859-63. PMID 25504624 DOI: 10.1002/Anie.201408817 |
0.326 |
|
| 2015 |
Harvey NL, Krysiak J, Chamni S, Cho SW, Sieber SA, Romo D. Synthesis of (±)-spongiolactone enabling discovery of a more potent derivative. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 1425-8. PMID 25488266 DOI: 10.1002/Chem.201405980 |
0.763 |
|
| 2015 |
Chen R, Zhu M, Chen Y, Skillern W, Wierda WG, Hull K, Romo D, Plunkett W. Abstract 1765: Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia Cancer Research. 75: 1765-1765. DOI: 10.1158/1538-7445.Am2015-1765 |
0.315 |
|
| 2015 |
Romo D. Bioactivity-guided retrosynthesis: “Upping the ante” for natural product total synthesis Planta Medica. 81. DOI: 10.1055/s-0035-1556096 |
0.317 |
|
| 2014 |
Abbasov ME, Romo D. The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis. Natural Product Reports. 31: 1318-27. PMID 25042097 DOI: 10.1039/C4Np00025K |
0.802 |
|
| 2014 |
McMillan AW, Lopez MS, Zhu M, Morse BC, Yeo IC, Amos J, Hull K, Romo D, Glasner ME. Role of an active site loop in the promiscuous activities of Amycolatopsis sp. T-1-60 NSAR/OSBS. Biochemistry. 53: 4434-44. PMID 24955846 DOI: 10.1021/Bi500573V |
0.302 |
|
| 2014 |
Brizendine AM, Odokonyero D, McMillan AW, Zhu M, Hull K, Romo D, Glasner ME. Promiscuity of Exiguobacterium sp. AT1b o-succinylbenzoate synthase illustrates evolutionary transitions in the OSBS family. Biochemical and Biophysical Research Communications. 450: 679-84. PMID 24937446 DOI: 10.1016/J.Bbrc.2014.06.034 |
0.345 |
|
| 2014 |
Abbasov ME, Hudson BM, Tantillo DJ, Romo D. Acylammonium salts as dienophiles in Diels-Alder/lactonization organocascades. Journal of the American Chemical Society. 136: 4492-5. PMID 24588428 DOI: 10.1021/Ja501005G |
0.817 |
|
| 2014 |
Low WK, Li J, Zhu M, Kommaraju SS, Shah-Mittal J, Hull K, Liu JO, Romo D. Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents. Bioorganic & Medicinal Chemistry. 22: 116-25. PMID 24359706 DOI: 10.1016/J.Bmc.2013.11.046 |
0.448 |
|
| 2013 |
Liu G, Shirley ME, Van KN, McFarlin RL, Romo D. Rapid assembly of complex cyclopentanes employing chiral, α,β-unsaturated acylammonium intermediates. Nature Chemistry. 5: 1049-57. PMID 24256870 DOI: 10.1038/Nchem.1788 |
0.508 |
|
| 2013 |
Vellalath S, Van KN, Romo D. Direct catalytic asymmetric synthesis of N-heterocycles from commodity acid chlorides by employing α,β-unsaturated acylammonium salts. Angewandte Chemie (International Ed. in English). 52: 13688-93. PMID 24173690 DOI: 10.1002/anie.201306050 |
0.375 |
|
| 2013 |
Li J, Cisar JS, Zhou CY, Vera B, Williams H, RodrÃguez AD, Cravatt BF, Romo D. Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate. Nature Chemistry. 5: 510-7. PMID 23695633 DOI: 10.1038/Nchem.1653 |
0.559 |
|
| 2013 |
Ranieri B, Robles O, Romo D. Concise synthesis of the isothiourea organocatalysts homobenzotetramisole and derivatives. The Journal of Organic Chemistry. 78: 6291-6. PMID 23688163 DOI: 10.1021/Jo400603N |
0.491 |
|
| 2013 |
Ranieri B, Robles O, Romo D. Correction to “Concise Synthesis of the Isothiourea Organocatalysts Homobenzotetramisole and Derivatives” The Journal of Organic Chemistry. 78: 8215-8215. DOI: 10.1021/Jo4015485 |
0.423 |
|
| 2013 |
Leverett CA, Purohit VC, Johnson AG, Davis RL, Tantillo DJ, Romo D. Correction to “Dyotropic Rearrangements of Fused Tricyclic β-Lactones: Application to the Synthesis of (−)-Curcumanolide A and (−)-Curcumalactone” Journal of the American Chemical Society. 135: 12478-12478. DOI: 10.1021/Ja407284G |
0.714 |
|
| 2012 |
Leverett CA, Purohit VC, Johnson AG, Davis RL, Tantillo DJ, Romo D. Dyotropic rearrangements of fused tricyclic β-lactones: application to the synthesis of (-)-curcumanolide A and (-)-curcumalactone. Journal of the American Chemical Society. 134: 13348-56. PMID 22853802 DOI: 10.1021/Ja303414A |
0.773 |
|
| 2012 |
Reyes JC, Romo D. Bioinspired total synthesis of agelastatin A. Angewandte Chemie (International Ed. in English). 51: 6870-3. PMID 22689447 DOI: 10.1002/anie.201200959 |
0.36 |
|
| 2012 |
Stout EP, Wang YG, Romo D, Molinski TF. Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica. Angewandte Chemie (International Ed. in English). 51: 4877-81. PMID 22473581 DOI: 10.1002/Anie.201108119 |
0.559 |
|
| 2012 |
Stout EP, Morinaka BI, Wang YG, Romo D, Molinski TF. De novo synthesis of benzosceptrin C and nagelamide H from 7-15N-oroidin: implications for pyrrole-aminoimidazole alkaloid biosynthesis. Journal of Natural Products. 75: 527-30. PMID 22455452 DOI: 10.1021/Np300051K |
0.613 |
|
| 2012 |
Robles O, Serna-Saldívar SO, Gutiérrez-Uribe JA, Romo D. Cyclopropanations of olefin-containing natural products for simultaneous arming and structure activity studies. Organic Letters. 14: 1394-7. PMID 22360738 DOI: 10.1021/Ol300105Q |
0.38 |
|
| 2012 |
Liu G, Shirley ME, Romo D. A diastereoselective, nucleophile-promoted aldol-lactonization of ketoacids leading to bicyclic-β-lactones. The Journal of Organic Chemistry. 77: 2496-500. PMID 22260519 DOI: 10.1021/Jo202252Y |
0.424 |
|
| 2012 |
Zhao C, Mitchell TA, Vallakati R, Pérez LM, Romo D. Mechanistic investigations of the ZnCl2-mediated tandem Mukaiyama aldol lactonization: evidence for asynchronous, concerted transition states and discovery of 2-oxopyridyl ketene acetal variants. Journal of the American Chemical Society. 134: 3084-94. PMID 22239064 DOI: 10.1021/Ja209163W |
0.501 |
|
| 2012 |
Nguyen H, Oh S, Henry-Riyad H, Sepulveda D, Romo D. Organocatalytic enantioselective synthesis of bicyclic β-lactones from aldehyde acids via nucleophile-catalyzed aldollactonization (NCAL) Organic Syntheses. 88: 121-137. DOI: 10.15227/orgsyn.088.0121 |
0.38 |
|
| 2012 |
Reyes JCP, Romo D. Back Cover: Bioinspired Total Synthesis of Agelastatin A (Angew. Chem. Int. Ed. 28/2012) Angewandte Chemie International Edition. 51: 7050-7050. DOI: 10.1002/Anie.201204757 |
0.401 |
|
| 2012 |
Reyes JCP, Romo D. Rücktitelbild: Bioinspired Total Synthesis of Agelastatin A (Angew. Chem. 28/2012) Angewandte Chemie. 124: 7156-7156. DOI: 10.1002/ange.201204757 |
0.339 |
|
| 2012 |
Nguyen H, Oh S, Henry‐Riyad H, Sepulveda D, Romo D. Organocatalytic Enantioselective Synthesis of Bicyclic β‐Lactones Via Nucleophile‐Catalyzed Aldol‐Lactonization (NCAL) Organic Syntheses. 121-137. DOI: 10.1002/0471264229.Os088.12 |
0.776 |
|
| 2011 |
Kong K, Moussa Z, Lee C, Romo D. Total synthesis of the spirocyclic imine marine toxin (-)-gymnodimine and an unnatural C4-epimer. Journal of the American Chemical Society. 133: 19844-56. PMID 22023219 DOI: 10.1021/Ja207385Y |
0.675 |
|
| 2011 |
Chamni S, He QL, Dang Y, Bhat S, Liu JO, Romo D. Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion. Acs Chemical Biology. 6: 1175-81. PMID 21894934 DOI: 10.1021/Cb2002686 |
0.723 |
|
| 2011 |
Davis RL, Leverett CA, Romo D, Tantillo DJ. Switching between concerted and stepwise mechanisms for dyotropic rearrangements of β-lactones leading to spirocyclic, bridged γ-butyrolactones. The Journal of Organic Chemistry. 76: 7167-74. PMID 21770451 DOI: 10.1021/Jo2012175 |
0.35 |
|
| 2011 |
Liu G, Romo D. Total synthesis of (+)-omphadiol. Angewandte Chemie (International Ed. in English). 50: 7537-40. PMID 21761524 DOI: 10.1002/Anie.201102289 |
0.508 |
|
| 2011 |
Al-Mourabit A, Zancanella MA, Tilvi S, Romo D. Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids. Natural Product Reports. 28: 1229-60. PMID 21556392 DOI: 10.1039/C0Np00013B |
0.788 |
|
| 2011 |
Nguyen H, Ma G, Gladysheva T, Fremgen T, Romo D. Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations. The Journal of Organic Chemistry. 76: 2-12. PMID 21047113 DOI: 10.1021/Jo101638R |
0.622 |
|
| 2011 |
Liu G, Romo D. Cover Picture: Total Synthesis of (+)-Omphadiol (Angew. Chem. Int. Ed. 33/2011) Angewandte Chemie International Edition. 50: 7449-7449. DOI: 10.1002/Anie.201104527 |
0.462 |
|
| 2011 |
Liu G, Romo D. Titelbild: Total Synthesis of (+)-Omphadiol (Angew. Chem. 33/2011) Angewandte Chemie. 123: 7587-7587. DOI: 10.1002/Ange.201104527 |
0.507 |
|
| 2010 |
Romo D. Natural-product synthesis: stitching together palau'amine. Nature Chemistry. 2: 159-60. PMID 21124468 DOI: 10.1038/Nchem.565 |
0.501 |
|
| 2010 |
Leverett CA, Purohit VC, Romo D. Enantioselective, organocatalyzed, intramolecular aldol lactonizations with keto acids leading to bi- and tricyclic β-lactones and topology-morphing transformations. Angewandte Chemie (International Ed. in English). 49: 9479-83. PMID 21053228 DOI: 10.1002/Anie.201004671 |
0.736 |
|
| 2010 |
Morris KA, Arendt KM, Oh SH, Romo D. Double diastereoselective, nucleophile-catalyzed aldol lactonizations (NCAL) leading to beta-lactone fused carbocycles and extensions to beta-lactone fused tetrahydrofurans. Organic Letters. 12: 3764-7. PMID 20704184 DOI: 10.1021/Ol101388H |
0.627 |
|
| 2010 |
Nguyen H, Ma G, Romo D. A(1,3)-strain enabled retention of chirality during bis-cyclization of beta-ketoamides: total synthesis of (-)-salinosporamide A and (-)-homosalinosporamide A. Chemical Communications (Cambridge, England). 46: 4803-5. PMID 20498903 DOI: 10.1039/C0Cc00607F |
0.594 |
|
| 2010 |
Wang YG, Morinaka BI, Reyes JC, Wolff JJ, Romo D, Molinski TF. Synthesis of 7-(15)N-Oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale (1)H-(15)N HSQC and FTMS. Journal of Natural Products. 73: 428-34. PMID 20095632 DOI: 10.1021/Np900638E |
0.499 |
|
| 2010 |
Romo D, Leverett C, Purohit V. Organocatalytic Construction of Polycyclic Compounds Synfacts. 2011: 0099-0099. DOI: 10.1055/S-0030-1259182 |
0.67 |
|
| 2010 |
Kong K, Romo D, Lee C. Synthesis of (-)-Gymnodimine Synfacts. 2010: 15-15. DOI: 10.1055/S-0029-1218264 |
0.459 |
|
| 2010 |
LIU Y, ZHAO C, BERGBREITER DE, ROMO D. ChemInform Abstract: Simultaneous Deprotection and Purification of Boc-Amines on Ionic Resin Capture. Cheminform. 29: no-no. DOI: 10.1002/chin.199836103 |
0.37 |
|
| 2010 |
SCHMITZ WD, ROMO D. ChemInform Abstract: A New Route to 2-Substituted δ2-Thiazolines: Stille Cross- Couplings of 2-Bromo-δ2-thiazolines. Cheminform. 27: no-no. DOI: 10.1002/chin.199641132 |
0.683 |
|
| 2009 |
Duffy RJ, Morris KA, Romo D. Synthesis of Unusually Strained Spiro Ring Systems and Their Exploits in Synthesis. Tetrahedron. 65: 5879-5892. PMID 20640036 DOI: 10.1016/J.Tet.2008.06.090 |
0.77 |
|
| 2009 |
Kong K, Romo D, Lee C. Enantioselective total synthesis of the marine toxin (-)-gymnodimine employing a Barbier-type macrocyclization. Angewandte Chemie (International Ed. in English). 48: 7402-5. PMID 19728353 DOI: 10.1002/Anie.200903432 |
0.607 |
|
| 2009 |
Dang Y, Low WK, Xu J, Gehring NH, Dietz HC, Romo D, Liu JO. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. The Journal of Biological Chemistry. 284: 23613-21. PMID 19570977 DOI: 10.1074/Jbc.M109.009985 |
0.361 |
|
| 2009 |
Duffy RJ, Morris KA, Vallakati R, Zhang W, Romo D. Asymmetric synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones including facile conversion to tetronic acids: application to (+)-maculalactone A. The Journal of Organic Chemistry. 74: 4772-81. PMID 19453152 DOI: 10.1021/Jo900499E |
0.798 |
|
| 2009 |
Liu G, Romo D. Enantioselective synthesis of schulzeines B and C via a beta-lactone-derived surrogate for bishomoserine aldehyde. Organic Letters. 11: 1143-6. PMID 19209875 DOI: 10.1021/Ol802992M |
0.545 |
|
| 2008 |
Mitchell TA, Zhao C, Romo D. Diastereoselective, three-component cascade synthesis of tetrahydrofurans and tetrahydropyrans employing the tandem Mukaiyama aldol-lactonization process. The Journal of Organic Chemistry. 73: 9544-51. PMID 19053579 DOI: 10.1021/Jo801604K |
0.565 |
|
| 2008 |
Richardson RD, Ma G, Oyola Y, Zancanella M, Knowles LM, Cieplak P, Romo D, Smith JW. Synthesis of novel beta-lactone inhibitors of fatty acid synthase. Journal of Medicinal Chemistry. 51: 5285-96. PMID 18710210 DOI: 10.1021/Jm800321H |
0.793 |
|
| 2008 |
Zancanella MA, Romo D. Facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of the palau'amines and the tricyclic core of the axinellamines from a common intermediate. Organic Letters. 10: 3685-8. PMID 18693745 DOI: 10.1021/Ol801289B |
0.819 |
|
| 2008 |
Purohit VC, Matla AS, Romo D. Concise synthesis of spirocyclic, bridged gamma-butyrolactones via stereospecific, dyotropic rearrangements of beta-lactones involving 1,2-acyl and delta-lactone migrations. Journal of the American Chemical Society. 130: 10478-9. PMID 18627148 DOI: 10.1021/Ja803579Z |
0.725 |
|
| 2008 |
Mitchell TA, Zhao C, Romo D. Highly diastereoselective, tandem, three-component synthesis of tetrahydrofurans from ketoaldehydes via silylated beta-lactone intermediates. Angewandte Chemie (International Ed. in English). 47: 5026-9. PMID 18504788 DOI: 10.1002/Anie.200800235 |
0.513 |
|
| 2008 |
Zhang W, Richardson RD, Chamni S, Smith JW, Romo D. Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase. Bioorganic & Medicinal Chemistry Letters. 18: 2491-4. PMID 18343106 DOI: 10.1016/J.Bmcl.2008.02.043 |
0.693 |
|
| 2008 |
Wang S, Romo D. Enantioselective synthesis of (+)-monobromophakellin and (+)-phakellin: a concise phakellin annulation strategy applicable to Palau'amine. Angewandte Chemie (International Ed. in English). 47: 1284-6. PMID 18175299 DOI: 10.1002/Anie.200703998 |
0.588 |
|
| 2008 |
Purohit VC, Matla AS, Romo D. Recent advances in Lewis base-catalyzed, stereoselective, tandem aldol β- and γ-lactonizations Heterocycles. 76: 949-979. DOI: 10.3987/Rev-08-Sr(N)7 |
0.751 |
|
| 2008 |
Romo D, Wang S. Synthesis of (+)-Phakellin Synfacts. 2008: 0678-0678. DOI: 10.1055/s-2008-1077859 |
0.352 |
|
| 2007 |
Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Rzasa RM, Shea HA, Li S, Park K, Ma G, Romo D, Liu JO. Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A. Methods in Enzymology. 431: 303-24. PMID 17923240 DOI: 10.1016/S0076-6879(07)31014-8 |
0.779 |
|
| 2007 |
Peddibhotla S, Dang Y, Liu JO, Romo D. Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics. Journal of the American Chemical Society. 129: 12222-31. PMID 17880073 DOI: 10.1021/Ja0733686 |
0.472 |
|
| 2007 |
Low WK, Dang Y, Bhat S, Romo D, Liu JO. Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chemistry & Biology. 14: 715-27. PMID 17584618 DOI: 10.1016/J.Chembiol.2007.05.012 |
0.337 |
|
| 2007 |
Ma G, Nguyen H, Romo D. Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway? Organic Letters. 9: 2143-6. PMID 17477539 DOI: 10.1021/Ol070616U |
0.604 |
|
| 2007 |
Zhang W, Matla AS, Romo D. Alkyl C-O ring cleavage of bicyclic beta-lactones with Normant reagents: synthesis of a Merck IND intermediate. Organic Letters. 9: 2111-4. PMID 17477537 DOI: 10.1021/ol070572p |
0.339 |
|
| 2007 |
Cho SW, Romo D. Total synthesis of (-)-belactosin C and derivatives via double diastereoselective tandem mukaiyama aldol lactonizations. Organic Letters. 9: 1537-40. PMID 17378572 DOI: 10.1021/Ol070275K |
0.619 |
|
| 2007 |
Tang L, Romo D. Synthesis of a cyclic guanidine hemiaminal pertinent to the axinellamines Heterocycles. 74: 999-1008. DOI: 10.3987/Com-07-S(W)66 |
0.384 |
|
| 2006 |
Zhou M, Sivaramakrishnan A, Ponnamperuma K, Low WK, Li C, Liu JO, Bergbreiter DE, Romo D. Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography. Organic Letters. 8: 5247-50. PMID 17078689 DOI: 10.1021/Ol062045W |
0.416 |
|
| 2006 |
Ma G, Zancanella M, Oyola Y, Richardson RD, Smith JW, Romo D. Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase. Organic Letters. 8: 4497-500. PMID 16986934 DOI: 10.1021/Ol061651O |
0.807 |
|
| 2006 |
Henry-Riyad H, Lee C, Purohit VC, Romo D. Bicyclic- and tricyclic-beta-lactones via organonucleophile-promoted bis-cyclizations of keto acids: Enantioselective synthesis of (+)-dihydroplakevulin. Organic Letters. 8: 4363-6. PMID 16956227 DOI: 10.1021/Ol061816T |
0.767 |
|
| 2006 |
Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Kaufman R, Anderson P, Liu JO. Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. The Journal of Biological Chemistry. 281: 32870-8. PMID 16951406 DOI: 10.1074/Jbc.M606149200 |
0.316 |
|
| 2006 |
Kong K, Romo D. Diastereoselective, vinylogous mukaiyama aldol additions of silyloxy furans to cyclic ketones: annulation of butenolides and gamma-lactones. Organic Letters. 8: 2909-12. PMID 16805514 DOI: 10.1021/Ol060534Q |
0.645 |
|
| 2006 |
Purohit VC, Richardson RD, Smith JW, Romo D. Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase. The Journal of Organic Chemistry. 71: 4549-58. PMID 16749788 DOI: 10.1021/Jo060392D |
0.726 |
|
| 2006 |
Moussa Z, Romo D. Mild deprotection of primary N-(p-toluenesulfonyl) amides with SmI 2 following trifluoroacetylation Synlett. 3294-3298. DOI: 10.1055/S-2006-951530 |
0.325 |
|
| 2006 |
Wang S, Dilley AS, Poullennec KG, Romo D. Planned and unplanned halogenations in route to selected oroidin alkaloids Tetrahedron. 62: 7155-7161. DOI: 10.1016/J.Tet.2006.01.115 |
0.808 |
|
| 2006 |
Dransfield PJ, Dilley AS, Wang S, Romo D. A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal Tetrahedron. 62: 5223-5247. DOI: 10.1016/J.Tet.2005.12.068 |
0.756 |
|
| 2005 |
Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Merrick WC, Romo D, Liu JO. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Molecular Cell. 20: 709-22. PMID 16337595 DOI: 10.1016/J.Molcel.2005.10.008 |
0.4 |
|
| 2005 |
Duffy RJ, Morris KA, Romo D. Synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones obtained by epoxidation of 4-alkylidene-2-oxetanones. Journal of the American Chemical Society. 127: 16754-5. PMID 16316199 DOI: 10.1021/Ja053478H |
0.75 |
|
| 2005 |
Kong K, Moussa Z, Romo D. Studies toward a marine toxin immunogen: enantioselective synthesis of the spirocyclic imine of (-)-gymnodimine. Organic Letters. 7: 5127-30. PMID 16268519 DOI: 10.1021/Ol051840R |
0.674 |
|
| 2005 |
Dransfield PJ, Wang S, Dilley A, Romo D. Highly regioselective Diels-Alder reactions toward oroidin alkaloids: use of a tosylvinyl moiety as a nitrogen masking group with adjustable electronics. Organic Letters. 7: 1679-82. PMID 15844879 DOI: 10.1021/Ol0473602 |
0.697 |
|
| 2005 |
Oh SH, Cortez GS, Romo D. Asymmetric synthesis of bicyclic beta-lactones via the intramolecular, nucleophile-catalyzed aldol lactonization: improved efficiency and expanded scope. The Journal of Organic Chemistry. 70: 2835-8. PMID 15787582 DOI: 10.1021/Jo050024U |
0.456 |
|
| 2005 |
Andrew Mitchell T, Romo D. Radical reactions and α-silylations of optically active 4-trichloromethyl-β-lactone Heterocycles. 66: 627-637. DOI: 10.3987/Com-05-S(K)53 |
0.366 |
|
| 2004 |
Romo D, Choi NS, Li S, Buchler I, Shi Z, Liu JO. Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine a: design, synthesis, and activity studies leading to a potent simplified derivative. Journal of the American Chemical Society. 126: 10582-8. PMID 15327314 DOI: 10.1021/Ja040065S |
0.41 |
|
| 2004 |
Wang Y, Tennyson RL, Romo D. β-lactones: Intermediates for natural product total synthesis and new transformations Heterocycles. 64: 605-658. DOI: 10.3987/Rev-04-Sr(P)3 |
0.721 |
|
| 2003 |
Poullennec KG, Romo D. Enantioselective total synthesis of (+)-dibromophakellstatin. Journal of the American Chemical Society. 125: 6344-5. PMID 12785755 DOI: 10.1021/Ja034575I |
0.83 |
|
| 2002 |
Singleton DA, Wang Y, Yang HW, Romo D. Mechanism and origin of stereoselectivity in Lewis acid catalyzed [2 + 2] cycloadditions of ketenes with aldehydes. Angewandte Chemie (International Ed. in English). 41: 1572-5. PMID 19750669 DOI: 10.1002/1521-3773(20020503)41:9<1572::Aid-Anie1572>3.0.Co;2-B |
0.719 |
|
| 2002 |
Wang Y, Romo D. Concise total synthesis of (+)-brefeldin A: a combined beta-lactone/cross-metathesis-based strategy. Organic Letters. 4: 3231-4. PMID 12227756 DOI: 10.1021/Ol026438G |
0.704 |
|
| 2002 |
Poullennec KG, Kelly AT, Romo D. Highly diastereoselective desymmetrizations of cyclo(Pro,Pro): an enantioselective strategy toward phakellstatin and phakellin. Organic Letters. 4: 2645-8. PMID 12153199 DOI: 10.1021/Ol026140Q |
0.799 |
|
| 2002 |
Yokota Y, Cortez GS, Romo D. Nucleophilic openings of bicyclic β-lactones via acyl C-O and alkyl C-O cleavage: Catalytic, asymmetric synthesis of a versatile, carbocyclic nucleoside precursor and protected transpentacin Tetrahedron. 58: 7075-7080. DOI: 10.1016/S0040-4020(02)00703-2 |
0.493 |
|
| 2002 |
Singleton DA, Wang Y, Yang HW, Romo D. Mechanism and origin of stereoselectivity in Lewis acid catalyzed [2 + 2] cycloadditions of ketenes with aldehydes Angewandte Chemie - International Edition. 41: 1572-1575. DOI: 10.1002/1521-3773(20020503)41:9<1572::AID-ANIE1572>3.0.CO;2-B |
0.698 |
|
| 2001 |
Cortez GS, Tennyson RL, Romo D. Intramolecular, nucleophile-catalyzed aldol-lactonization (NCAL) reactions: catalytic, asymmetric synthesis of bicyclic beta-lactones. Journal of the American Chemical Society. 123: 7945-6. PMID 11493084 DOI: 10.1021/Ja016134+ |
0.447 |
|
| 2001 |
Dilley AS, Romo D. Enantioselective strategy to the spirocyclic core of Palau'amine and related bisguanidine marine alkaloids. Organic Letters. 3: 1535-8. PMID 11388860 DOI: 10.1021/Ol015864J |
0.69 |
|
| 2001 |
Ahn Y, Cardenas GI, Yang J, Romo D. Studies toward gymnodimine: development of a single-pot Hua reaction for the synthesis of highly hindered cyclic imines. Organic Letters. 3: 751-4. PMID 11259053 DOI: 10.1021/ol0155081 |
0.336 |
|
| 2001 |
Cortez GS, Oh SH, Romo D. Bicyclic β-lactones via intramolecular NCAL reactions with cinchona alkaloids: Effect of the C9-substituent on enantioselectivity and catalyst conformation Synthesis. 1731-1736. DOI: 10.1055/S-2001-16746 |
0.38 |
|
| 2000 |
Romo D, Rzasa RM, Schmitz WD, Yang J, Cohn ST, Buchler IP, Shea HA, Park K, Langenhan JM, Messerschmidt NB, Cox MM. Total synthesis of marine natural products driven by novel structure, potent biological activity, and/or synthetic methodology. Ernst Schering Research Foundation Workshop. 103-48. PMID 11077607 |
0.813 |
|
| 2000 |
Tennyson R, Romo D. Use of In situ generated ketene in the wynberg beta-lactone synthesis: new transformations of the dichlorinated beta-lactone products The Journal of Organic Chemistry. 65: 7248-52. PMID 11031063 DOI: 10.1021/Jo001010L |
0.343 |
|
| 1999 |
Wang Y, Zhao C, Romo D. A stereocomplementary approach to β-lactones: Highly diastereoselective synthesis of cis-β-lactones, a β-chloro acid, and a tetrahydrofuran Organic Letters. 1: 1197-1199. DOI: 10.1021/Ol990860O |
0.708 |
|
| 1999 |
Yang HW, Romo D. Corrigendum to Tetrahedron report number 492: “Methods for the synthesis of optically active β-lactones (2-oxetanones)” [Tetrahedron 55 (1999) 6403] Tetrahedron. 55: 9347. DOI: 10.1016/S0040-4020(99)00515-3 |
0.441 |
|
| 1999 |
Yang HW, Romo D. Methods for the synthesis of optically active β-lactones (2- oxetanones) Tetrahedron. 55: 6403-6434. DOI: 10.1016/S0040-4020(99)00185-4 |
0.433 |
|
| 1998 |
Romo D, Harrison PH, Jenkins SI, Riddoch RW, Park K, Yang HW, Zhao C, Wright GD. Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones). Bioorganic & Medicinal Chemistry. 6: 1255-72. PMID 9784867 DOI: 10.1016/S0968-0896(98)00114-X |
0.586 |
|
| 1998 |
Schmitz WD, Messerschmidt NB, Romo D. A β-lactone-based strategy applied to the total synthesis of (8S,21S,22S,23R)- and (8R,21S,22S,23R)-okinonellin B Journal of Organic Chemistry. 63: 2058-2059. DOI: 10.1021/Jo9722360 |
0.687 |
|
| 1998 |
Liu Y, Zhao C, Bergbreiter DE, Romo D. Simultaneous Deprotection and Purification of BOC-amines Based on Ionic Resin Capture The Journal of Organic Chemistry. 63: 3471-3473. DOI: 10.1021/Jo972001O |
0.457 |
|
| 1998 |
Romo D, Rzasa RM, Shea HA, Park K, Langenhan JM, Sun L, Akhiezer A, Liu JO. Total synthesis and immunosuppressive activity of (-)-pateamine A and related compounds: Implementation of a β-lactam-based macrocyclization Journal of the American Chemical Society. 120: 12237-12254. DOI: 10.1021/Ja981846U |
0.811 |
|
| 1998 |
Rzasa RM, Shea HA, Romo D. Total synthesis of the novel, immunosuppressive agent (-)-pateamine A from Mycale sp. employing a β-lactam-based macrocyclization Journal of the American Chemical Society. 120: 591-592. DOI: 10.1021/Ja973549F |
0.774 |
|
| 1998 |
Yang HW, Romo D. Studies of the asymmetric [2+2] cycloaddition of silylketenes and aldehydes employing Ti-TADDOL catalysts Tetrahedron Letters. 39: 2877-2880. DOI: 10.1016/S0040-4039(98)00422-5 |
0.331 |
|
| 1997 |
Yang HW, Romo D. A Highly Diastereoselective, Tandem Mukaiyama Aldol-Lactonization Route to beta-Lactones: Application to a Concise Synthesis of the Potent Pancreatic Lipase Inhibitor, (-)-Panclicin D. The Journal of Organic Chemistry. 62: 4-5. PMID 11671357 DOI: 10.1021/Jo9619488 |
0.378 |
|
| 1997 |
Yang HW, Romo D. A highly diastereoselective, tandem Mukaiyama aldol-lactonization route to β-lactones: Application to a concise synthesis of the potent pancreatic lipase inhibitor, (-)-panclicin D Journal of Organic Chemistry. 62: 4-5. DOI: 10.1021/jo9619488 |
0.401 |
|
| 1997 |
Zhao C, Romo D. A β-lactone-based route to cyclopentanes via intramolecular allylsilane additions. An unexpected friedel-crafts alkylation Tetrahedron Letters. 38: 6537-6540. DOI: 10.1016/S0040-4039(97)01529-3 |
0.475 |
|
| 1997 |
Yang HW, Zhao C, Romo D. Studies of the tandem mukaiyama aldol-lactonization (TMAL) reaction: A concise and highly diastereoselective route to β-lactones applied to the total synthesis of the potent pancreatic lipase inhibitor, (-)-Panclicin D Tetrahedron. 53: 16471-16488. DOI: 10.1016/S0040-4020(97)01029-6 |
0.54 |
|
| 1996 |
Zemribo R, Champ MS, Romo D. Tandem Transacylation/Debenzylation of β-Lactones Mediated by FeCl3 Leading to γ- and δ-Lactones: Application to the Synthesis of (-)-Grandinolide Synlett. 1996: 278-280. DOI: 10.1055/S-1996-5391 |
0.41 |
|
| 1995 |
Rzasa RM, Romo D, Stirling DJ, Blunt JW, Munro MHG. Structural and synthetic studies of the pateamines: Synthesis and absolute configuration of the hydroxydienoate fragment Tetrahedron Letters. 36: 5307-5310. DOI: 10.1016/0040-4039(95)01021-9 |
0.793 |
|
| 1995 |
Zemribo R, Romo D. Highly diastereoselective [2+2] cycloadditions via chelation control: Asymmetric synthesis of β-lactones Tetrahedron Letters. 36: 4159-4162. DOI: 10.1016/0040-4039(95)00716-P |
0.412 |
|
| 1994 |
Belshaw PJ, Meyer SD, Johnson DD, Romo D, Ikeda Y, Andrus M, Alberg DG, Schultz LW, Clardy J, Schreiber SL. Synthesis, Structure and Mechanism in Immunophilin Research Synlett. 1994: 381-392. DOI: 10.1055/S-1994-22863 |
0.774 |
|
| 1993 |
Romo D, Meyer SD, Johnson DD, Schreiber SL. Total synthesis of (-)-rapamycin using an Evans-Tishchenko fragment coupling Journal of the American Chemical Society. 115: 7906-7907. DOI: 10.1021/Ja00070A058 |
0.514 |
|
| 1992 |
Romo D, Meyers AI. An asymmetric route to enantiomerically pure 1,2,3-trisubstituted cyclopropanes Journal of Organic Chemistry. 57: 6265-6270. DOI: 10.1021/Jo00049A038 |
0.665 |
|
| 1992 |
Romo D, Johnson DD, Plamondon L, Miwa T, Schreiber SL. Synthetic investigations of rapamycin. 2. Synthesis of a C(22)-C(42) fragment The Journal of Organic Chemistry. 57: 5060-5063. DOI: 10.1021/Jo00045A008 |
0.527 |
|
| 1991 |
Romo D, Meyers AI. Chiral non-racemic bicyclic lactams. Vehicles for the construction of natural and unnatural products containing quaternary carbon centers Tetrahedron. 47: 9503-9569. DOI: 10.1016/S0040-4020(01)91024-5 |
0.614 |
|
| 1990 |
Romo D, Romine JL, Midura W, Meyers A. Diastereoselective cyclopropanations of chiral bicyclic lactams leading to enantiomerically pure cyclopropanes. Application to the total synthesis of CIS-(1S, 3R)-deltamethrinic acid and R-(-)- dictyopterene C Tetrahedron. 46: 4951-4994. DOI: 10.1016/S0040-4020(01)85604-0 |
0.666 |
|
| 1989 |
Meyers A, Romo D. Chiral bicyclic lactams. An asymmetric synthesis of cis-(1s, 3r) deltamethrinic acid Tetrahedron Letters. 30: 1745-1748. DOI: 10.1016/S0040-4039(00)99569-8 |
0.682 |
|
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