Gregory Stephanopoulos - Publications

Chemical Engineering Department Massachusetts Institute of Technology, Cambridge, MA, United States 
metabolic and biochemical engineering, biotechnology, bioinformatics

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liu Y, Low ZJ, Ma X, Liang H, Stephanopoulos G, Sinskey AJ, Zhou K. Using biopolymer bodies for encapsulation of hydrophobic products in bacterium. Metabolic Engineering. PMID 32339760 DOI: 10.1016/j.ymben.2020.04.006  0.44
2019 Mano J, Liu N, Hammond JH, Currie DH, Stephanopoulos G. Engineering Yarrowia lipolytica for the utilization of acid whey. Metabolic Engineering. PMID 31562926 DOI: 10.1016/j.ymben.2019.09.010  0.6
2019 Liu N, Santala S, Stephanopoulos G. Mixed carbon substrates: a necessary nuisance or a missed opportunity? Current Opinion in Biotechnology. 62: 15-21. PMID 31513988 DOI: 10.1016/j.copbio.2019.07.003  0.6
2018 Emerson DF, Woolston BM, Liu N, Donnelly M, Currie DH, Stephanopoulos G. Enhancing H -dependent growth of and CO fixation by Clostridium ljungdahlii through nitrate supplementation. Biotechnology and Bioengineering. PMID 30267586 DOI: 10.1002/bit.26847  0.6
2018 Abdel-Mawgoud AM, Markham KA, Palmer CM, Liu N, Stephanopoulos G, Alper HS. Metabolic engineering in the host Yarrowia lipolytica. Metabolic Engineering. PMID 30056205 DOI: 10.1016/j.ymben.2018.07.016  0.6
2018 Lazar Z, Liu N, Stephanopoulos G. Holistic Approaches in Lipid Production by Yarrowia lipolytica. Trends in Biotechnology. PMID 30006239 DOI: 10.1016/j.tibtech.2018.06.007  0.6
2018 Woolston BM, King JR, Reiter M, Van Hove B, Stephanopoulos G. Improving formaldehyde consumption drives methanol assimilation in engineered E. coli. Nature Communications. 9: 2387. PMID 29921903 DOI: 10.1038/s41467-018-04795-4  0.32
2018 Li ZJ, Hong PH, Da YY, Li LK, Stephanopoulos G. Metabolic engineering of Escherichia coli for the production of L-malate from xylose. Metabolic Engineering. PMID 29800611 DOI: 10.1016/j.ymben.2018.05.010  0.44
2017 Li ZJ, Qiao K, Che XM, Stephanopoulos G. Metabolic engineering of Escherichia coli for the synthesis of the quadripolymer poly(glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose. Metabolic Engineering. PMID 28916461 DOI: 10.1016/j.ymben.2017.09.003  0.6
2017 Xu J, Liu N, Qiao K, Vogg S, Stephanopoulos G. Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630295 DOI: 10.1073/pnas.1703321114  0.6
2017 King JR, Woolston BM, Stephanopoulos G. Designing a new entry point into isoprenoid metabolism by exploiting fructose-6-phosphate aldolase side-reactivity of Escherichia coli. Acs Synthetic Biology. PMID 28375628 DOI: 10.1021/acssynbio.7b00072  0.32
2017 Xu P, Qiao K, Stephanopoulos G. Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica. Biotechnology and Bioengineering. PMID 28295166 DOI: 10.1002/bit.26285  0.6
2017 Qiao K, Wasylenko TM, Zhou K, Xu P, Stephanopoulos G. Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism. Nature Biotechnology. PMID 28092657 DOI: 10.1038/nbt.3763  0.6
2017 Vasdekis AE, Silverman AM, Stephanopoulos G. Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. Plos One. 12: e0168889. PMID 28052085 DOI: 10.1371/journal.pone.0168889  0.4
2016 Li ZJ, Qiao K, Liu N, Stephanopoulos G. Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production. Journal of Industrial Microbiology & Biotechnology. PMID 27826725 DOI: 10.1007/s10295-016-1864-1  0.6
2016 Edgar S, Li FS, Qiao K, Weng JK, Stephanopoulos G. Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate. Acs Synthetic Biology. PMID 27794603 DOI: 10.1021/acssynbio.6b00206  0.6
2016 Xu P, Qiao K, Ahn WS, Stephanopoulos G. Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621436 DOI: 10.1073/pnas.1607295113  0.6
2016 Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 4: 16. PMID 27540483 DOI: 10.1186/s40170-016-0156-6  0.68
2016 Xu P, Rizzoni EA, Sul SY, Stephanopoulos G. Improving metabolic pathway efficiency by statistical model based multivariate regulatory metabolic engineering (MRME). Acs Synthetic Biology. PMID 27490704 DOI: 10.1021/acssynbio.6b00187  0.48
2016 Liu N, Qiao K, Stephanopoulos G. (13)C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica. Metabolic Engineering. PMID 27387605 DOI: 10.1016/j.ymben.2016.06.006  0.92
2016 Zhang H, Stephanopoulos G. Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in Escherichia coli. Biotechnology Journal. PMID 27168529 DOI: 10.1002/biot.201600013  0.44
2016 King JR, Edgar S, Qiao K, Stephanopoulos G. Accessing Nature's diversity through metabolic engineering and synthetic biology. F1000research. 5. PMID 27081481 DOI: 10.12688/f1000research.7311.1  0.92
2016 Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK. Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951651 DOI: 10.1073/pnas.1515826113  0.92
2016 Hu P, Chakraborty S, Kumar A, Woolston B, Liu H, Emerson D, Stephanopoulos G. Integrated bioprocess for conversion of gaseous substrates to liquids. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951649 DOI: 10.1073/pnas.1516867113  0.92
2016 Silverman AM, Qiao K, Xu P, Stephanopoulos G. Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica. Applied Microbiology and Biotechnology. PMID 26915993 DOI: 10.1007/s00253-016-7376-0  0.92
2016 Li ZJ, Qiao K, Shi W, Pereira B, Zhang H, Olsen BD, Stephanopoulos G. Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli. Metabolic Engineering. PMID 26778413 DOI: 10.1016/j.ymben.2016.01.004  0.92
2015 Pereira B, Li ZJ, De Mey M, Giaw Lim C, Zhang H, Hoeltgen C, Stephanopoulos G. Efficient utilization of pentoses for bioproduction of the renewable two-carbon compounds ethylene glycol and glycolate. Metabolic Engineering. PMID 26711083 DOI: 10.1016/j.ymben.2015.12.004  0.92
2015 Cheng F, Gong Q, Yu H, Stephanopoulos G. High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum. Biotechnology Journal. PMID 26709615 DOI: 10.1002/biot.201500404  0.92
2015 Edgar S, Zhou K, Qiao K, King JR, Simpson JH, Stephanopoulos G. Mechanistic Insights into Taxadiene Epoxidation by Taxadiene-5α-Hydroxylase. Acs Chemical Biology. PMID 26677870 DOI: 10.1021/acschembio.5b00767  0.92
2015 Zhang H, Li Z, Pereira B, Stephanopoulos G. Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 14: 134. PMID 26369810 DOI: 10.1186/s12934-015-0319-0  0.44
2015 Pereira B, Zhang H, De Mey M, Lim CG, Li ZJ, Stephanopoulos G. Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol. Biotechnology and Bioengineering. PMID 26221864 DOI: 10.1002/bit.25717  0.92
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524: 361-5. PMID 26168401 DOI: 10.1038/nature14587  0.92
2015 Zhang H, Pereira B, Li Z, Stephanopoulos G. Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences of the United States of America. PMID 26111796 DOI: 10.1073/pnas.1506781112  0.44
2015 Islam MA, Zengler K, Edwards EA, Mahadevan R, Stephanopoulos G. Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25994252 DOI: 10.1039/c5ib00095e  0.92
2015 Wasylenko TM, Ahn WS, Stephanopoulos G. The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica. Metabolic Engineering. 30: 27-39. PMID 25747307 DOI: 10.1016/j.ymben.2015.02.007  0.92
2015 Qiao K, Imam Abidi SH, Liu H, Zhang H, Chakraborty S, Watson N, Kumaran Ajikumar P, Stephanopoulos G. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. 29: 56-65. PMID 25732624 DOI: 10.1016/j.ymben.2015.02.005  0.92
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Stephanopoulos G, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/j.copbio.2015.02.003  0.92
2015 Zhou K, Qiao K, Edgar S, Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nature Biotechnology. 33: 377-83. PMID 25558867 DOI: 10.1038/nbt.3095  0.92
2015 Wasylenko TM, Stephanopoulos G. Metabolomic and (13)C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase. Biotechnology and Bioengineering. 112: 470-83. PMID 25311863 DOI: 10.1002/bit.25447  0.4
2014 Lam FH, Ghaderi A, Fink GR, Stephanopoulos G. Biofuels. Engineering alcohol tolerance in yeast. Science (New York, N.Y.). 346: 71-5. PMID 25278607 DOI: 10.1126/science.1257859  0.92
2014 Xu P, Li L, Zhang F, Stephanopoulos G, Koffas M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences of the United States of America. 111: 11299-304. PMID 25049420 DOI: 10.1073/pnas.1406401111  0.48
2014 Zhang J, Ahn WS, Gameiro PA, Keibler MA, Zhang Z, Stephanopoulos G. 13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells. Methods in Enzymology. 542: 369-89. PMID 24862276 DOI: 10.1016/B978-0-12-416618-9.00019-4  0.44
2014 Wang BL, Ghaderi A, Zhou H, Agresti J, Weitz DA, Fink GR, Stephanopoulos G. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nature Biotechnology. 32: 473-8. PMID 24705516 DOI: 10.1038/nbt.2857  0.92
2013 Chen X, Zhang C, Zou R, Zhou K, Stephanopoulos G, Too HP. Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. Plos One. 8: e79650. PMID 24278153 DOI: 10.1371/journal.pone.0079650  0.44
2013 Zou R, Zhou K, Stephanopoulos G, Too HP. Combinatorial engineering of 1-deoxy-D-xylulose 5-phosphate pathway using cross-lapping in vitro assembly (CLIVA) method. Plos One. 8: e79557. PMID 24223968 DOI: 10.1371/journal.pone.0079557  0.44
2013 Zhang C, Chen X, Zou R, Zhou K, Stephanopoulos G, Too HP. Combining genotype improvement and statistical media optimization for isoprenoid production in E. coli. Plos One. 8: e75164. PMID 24124471 DOI: 10.1371/journal.pone.0075164  0.44
2013 Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nature Communications. 4: 2236. PMID 23900562 DOI: 10.1038/ncomms3236  0.92
2013 Wasylenko TM, Stephanopoulos G. Kinetic isotope effects significantly influence intracellular metabolite (13) C labeling patterns and flux determination. Biotechnology Journal. 8: 1080-9. PMID 23828762 DOI: 10.1002/biot.201200276  0.4
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, ... ... Stephanopoulos G, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.CAN-13-0080  0.92
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/j.cell.2013.04.023  0.92
2013 Carlsen S, Ajikumar PK, Formenti LR, Zhou K, Phon TH, Nielsen ML, Lantz AE, Kielland-Brandt MC, Stephanopoulos G. Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology. 97: 5753-69. PMID 23636690 DOI: 10.1007/s00253-013-4877-y  0.92
2013 Woolston BM, Edgar S, Stephanopoulos G. Metabolic engineering: past and future. Annual Review of Chemical and Biomolecular Engineering. 4: 259-88. PMID 23540289 DOI: 10.1146/annurev-chembioeng-061312-103312  0.44
2013 Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. The Journal of Biological Chemistry. 288: 12967-77. PMID 23504317 DOI: 10.1074/jbc.M112.396796  0.68
2013 Zhou K, Zou R, Zhang C, Stephanopoulos G, Too HP. Optimization of amorphadiene synthesis in bacillus subtilis via transcriptional, translational, and media modulation. Biotechnology and Bioengineering. 110: 2556-61. PMID 23483530 DOI: 10.1002/bit.24900  0.44
2013 Hiller K, Wegner A, Weindl D, Cordes T, Metallo CM, Kelleher JK, Stephanopoulos G. NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. Bioinformatics (Oxford, England). 29: 1226-8. PMID 23479350 DOI: 10.1093/bioinformatics/btt119  0.92
2013 Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metabolism. 17: 372-85. PMID 23473032 DOI: 10.1016/j.cmet.2013.02.002  0.92
2013 Avalos JL, Fink GR, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nature Biotechnology. 31: 335-41. PMID 23417095 DOI: 10.1038/nbt.2509  0.92
2013 Zhang H, Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 97: 3333-41. PMID 23179615 DOI: 10.1007/s00253-012-4544-8  0.44
2013 Tai M, Stephanopoulos G. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production Metabolic Engineering. 15: 1-9. PMID 23026119 DOI: 10.1016/j.ymben.2012.08.007  0.92
2012 Jia G, Stephanopoulos G, Gunawan R. Incremental parameter estimation of kinetic metabolic network models. Bmc Systems Biology. 6: 142. PMID 23171810 DOI: 10.1186/1752-0509-6-142  0.92
2012 Zhou K, Zou R, Stephanopoulos G, Too HP. Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production. Microbial Cell Factories. 11: 148. PMID 23148661 DOI: 10.1186/1475-2859-11-148  0.44
2012 Zhou K, Zou R, Stephanopoulos G, Too HP. Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. Plos One. 7: e47513. PMID 23133596 DOI: 10.1371/journal.pone.0047513  0.44
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Stephanopoulos G, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/nchembio.1060  0.92
2012 Zhou H, Cheng JS, Wang BL, Fink GR, Stephanopoulos G. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metabolic Engineering. 14: 611-22. PMID 22921355 DOI: 10.1016/j.ymben.2012.07.011  0.92
2012 Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak M. Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway. Endocrine-Related Cancer. 19: 557-74. PMID 22685267 DOI: 10.1530/ERC-12-0125  0.92
2012 Walther JL, Metallo CM, Zhang J, Stephanopoulos G. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metabolic Engineering. 14: 162-71. PMID 22198197 DOI: 10.1016/j.ymben.2011.12.004  0.92
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/nature10602  0.92
2011 Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis. Metabolic Engineering. 13: 656-65. PMID 21907300 DOI: 10.1016/j.ymben.2011.08.002  0.32
2011 Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & Development. 25: 1716-33. PMID 21852536 DOI: 10.1101/gad.16771811  0.92
2011 Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Molecular Systems Biology. 7: 523. PMID 21847114 DOI: 10.1038/msb.2011.56  0.92
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Stephanopoulos G, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/ng.890  0.92
2011 Tyo KE, Nevoigt E, Stephanopoulos G. Directed evolution of promoters and tandem gene arrays for customizing RNA synthesis rates and regulation. Methods in Enzymology. 497: 135-55. PMID 21601085 DOI: 10.1016/B978-0-12-385075-1.00006-8  0.32
2011 Jia G, Stephanopoulos GN, Gunawan R. Parameter estimation of kinetic models from metabolic profiles: two-phase dynamic decoupling method. Bioinformatics (Oxford, England). 27: 1964-70. PMID 21558155 DOI: 10.1093/bioinformatics/btr293  0.92
2011 Zhou K, Zhou L, Lim Q', Zou R, Stephanopoulos G, Too HP. Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCR. Bmc Molecular Biology. 12: 18. PMID 21513543 DOI: 10.1186/1471-2199-12-18  0.44
2011 Hiller K, Metallo C, Stephanopoulos G. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics Current Pharmaceutical Biotechnology. 12: 1075-1086. PMID 21466455 DOI: 10.2174/138920111795909096  0.92
2011 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. Analytical Chemistry. 83: 3211-6. PMID 21413777 DOI: 10.1021/ac200012p  0.92
2011 Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular Biosystems. 7: 1409-19. PMID 21327189 DOI: 10.1039/c0mb00309c  0.68
2010 Lam FH, Hartner FS, Fink GR, Stephanopoulos G. Enhancing stress resistance and production phenotypes through transcriptome engineering. Methods in Enzymology. 470: 509-32. PMID 20946823 DOI: 10.1016/S0076-6879(10)70020-3  0.92
2010 Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (New York, N.Y.). 330: 70-4. PMID 20929806 DOI: 10.1126/science.1191652  0.32
2010 Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. Plos One. 5: e12057. PMID 20706589 DOI: 10.1371/journal.pone.0012057  0.68
2010 Jung SC, Smith CL, Lee KS, Hong ME, Kweon DH, Stephanopoulos G, Jin YS. Restoration of growth phenotypes of Escherichia coli DH5alpha in minimal media through reversal of a point mutation in purB. Applied and Environmental Microbiology. 76: 6307-9. PMID 20675450 DOI: 10.1128/AEM.01210-10  0.92
2010 Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KLJ. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control Proceedings of the National Academy of Sciences of the United States of America. 107: 13654-13659. PMID 20643967 DOI: 10.1073/pnas.1006138107  0.92
2010 Hiller K, Metallo CM, Kelleher JK, Stephanopoulos G. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Analytical Chemistry. 82: 6621-8. PMID 20608743 DOI: 10.1021/ac1011574  0.92
2010 Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.CAN-09-3399  0.92
2010 Shukla A, Fleming KE, Chuang HF, Chau TM, Loose CR, Stephanopoulos GN, Hammond PT. Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials. 31: 2348-57. PMID 20004967 DOI: 10.1016/j.biomaterials.2009.11.082  0.92
2010 Tyo KE, Fischer CR, Simeon F, Stephanopoulos G. Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations. Metabolic Engineering. 12: 187-95. PMID 19879956 DOI: 10.1016/j.ymben.2009.10.005  0.32
2009 Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. The Journal of Biological Chemistry. 284: 33425-36. PMID 19758988 DOI: 10.1074/jbc.M109.049478  0.68
2009 Alper H, Stephanopoulos G. Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential? Nature Reviews. Microbiology. 7: 715-23. PMID 19756010 DOI: 10.1038/nrmicro2186  0.92
2009 Tyo KE, Ajikumar PK, Stephanopoulos G. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. Nature Biotechnology. 27: 760-5. PMID 19633654 DOI: 10.1038/nbt.1555  0.32
2009 Metallo CM, Walther JL, Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Journal of Biotechnology. 144: 167-74. PMID 19622376 DOI: 10.1016/j.jbiotec.2009.07.010  0.92
2009 Tyo KE, Jin YS, Espinoza FA, Stephanopoulos G. Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803. Biotechnology Progress. 25: 1236-43. PMID 19606467 DOI: 10.1002/btpr.228  0.92
2009 Moxley JF, Jewett MC, Antoniewicz MR, Villas-Boas SG, Alper H, Wheeler RT, Tong L, Hinnebusch AG, Ideker T, Nielsen J, Stephanopoulos G. Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proceedings of the National Academy of Sciences of the United States of America. 106: 6477-82. PMID 19346491 DOI: 10.1073/pnas.0811091106  0.92
2008 Yoo H, Antoniewicz MR, Stephanopoulos G, Kelleher JK. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. The Journal of Biological Chemistry. 283: 20621-7. PMID 18364355 DOI: 10.1074/jbc.M706494200  0.92
2008 Young JD, Walther JL, Antoniewicz MR, Yoo H, Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnology and Bioengineering. 99: 686-99. PMID 17787013 DOI: 10.1002/bit.21632  0.92
2007 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Analytical Chemistry. 79: 7554-9. PMID 17822305 DOI: 10.1021/ac0708893  0.92
2007 Jin YS, Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metabolic Engineering. 9: 337-47. PMID 17509919 DOI: 10.1016/j.ymben.2007.03.003  0.92
2007 Antoniewicz MR, Kraynie DF, Laffend LA, González-Lergier J, Kelleher JK, Stephanopoulos G. Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol. Metabolic Engineering. 9: 277-92. PMID 17400499 DOI: 10.1016/j.ymben.2007.01.003  0.92
2007 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metabolic Engineering. 9: 68-86. PMID 17088092 DOI: 10.1016/j.ymben.2006.09.001  0.92
2006 Antoniewicz MR, Stephanopoulos G, Kelleher JK. Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway. Metabolomics : Official Journal of the Metabolomic Society. 2: 41-52. PMID 17066125 DOI: 10.1007/s11306-006-0018-2  0.92
2006 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metabolic Engineering. 8: 324-37. PMID 16631402 DOI: 10.1016/j.ymben.2006.01.004  0.92
2005 Jin YS, Alper H, Yang YT, Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Applied and Environmental Microbiology. 71: 8249-56. PMID 16332810 DOI: 10.1128/AEM.71.12.8249-8256.2005  0.92
2004 Lynch MD, Gill RT, Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metabolic Engineering. 6: 177-85. PMID 15256207 DOI: 10.1016/j.ymben.2004.01.002  0.68
2002 Gill RT, Katsoulakis E, Schmitt W, Taroncher-Oldenburg G, Misra J, Stephanopoulos G. Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803. Journal of Bacteriology. 184: 3671-81. PMID 12057963  0.68
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