Gregory Stephanopoulos - Publications

Affiliations: 
Chemical Engineering Department Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
metabolic and biochemical engineering, biotechnology, bioinformatics
Website:
https://cheme.mit.edu/profile/gregory-stephanopoulos/

323 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li C, Swofford CA, Rückert C, Chatzivasileiou AO, Ou RW, Opdensteinen P, Luttermann T, Zhou K, Stephanopoulos G, Jones Prather KL, Zhong-Johnson EZL, Liang S, Zheng S, Lin Y, Sinskey AJ. Heterologous production of α-Carotene in Corynebacterium glutamicum using a multi-copy chromosomal integration method. Bioresource Technology. 341: 125782. PMID 34419880 DOI: 10.1016/j.biortech.2021.125782  1
2021 Lam FH, Turanlı-Yıldız B, Liu D, Resch MG, Fink GR, Stephanopoulos G. Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks. Science Advances. 7. PMID 34172441 DOI: 10.1126/sciadv.abf7613  1
2021 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 184: 2256. PMID 33861966 DOI: 10.1016/j.cell.2021.03.059  1
2021 Sheneman L, Stephanopoulos G, Vasdekis AE. Deep learning classification of lipid droplets in quantitative phase images. Plos One. 16: e0249196. PMID 33819277 DOI: 10.1371/journal.pone.0249196  1
2021 Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, ... ... Stephanopoulos G, et al. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. The Febs Journal. PMID 33811729 DOI: 10.1111/febs.15858  1
2021 Santala S, Santala V, Liu N, Stephanopoulos G. Partitioning metabolism between growth and product synthesis for coordinated production of wax esters in Acinetobacter baylyi ADP1. Biotechnology and Bioengineering. PMID 33666232 DOI: 10.1002/bit.27740  1
2021 Katsimpouras C, Stephanopoulos G. Enzymes in biotechnology: Critical platform technologies for bioprocess development. Current Opinion in Biotechnology. 69: 91-102. PMID 33422914 DOI: 10.1016/j.copbio.2020.12.003  0.01
2020 Li J, Ma Y, Liu N, Eser BE, Guo Z, Jensen PR, Stephanopoulos G. Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism. Nature Communications. 11: 6198. PMID 33273473 DOI: 10.1038/s41467-020-19995-0  1
2020 Liang H, Ma X, Ning W, Liu Y, Sinskey AJ, Stephanopoulos G, Zhou K. Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds. Metabolic Engineering. PMID 33248272 DOI: 10.1016/j.ymben.2020.11.010  1
2020 Moon SJ, Dong W, Stephanopoulos GN, Sikes HD. Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress. Bioengineering & Translational Medicine. 5: e10184. PMID 33005744 DOI: 10.1002/btm2.10184  1
2020 Zu Y, Prather KL, Stephanopoulos G. Metabolic engineering strategies to overcome precursor limitations in isoprenoid biosynthesis. Current Opinion in Biotechnology. 66: 171-178. PMID 32853882 DOI: 10.1016/J.Copbio.2020.07.005  0.01
2020 Luo Z, Liu N, Lazar Z, Chatzivasileiou A, Ward V, Chen J, Zhou J, Stephanopoulos G. Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity. Metabolic Engineering. PMID 32758537 DOI: 10.1016/J.Ymben.2020.07.010  1
2020 Abdel-Mawgoud AM, Stephanopoulos G. Improving CRISPR/Cas9-mediated genome editing efficiency in Yarrowia lipolytica using direct tRNA-sgRNA fusions. Metabolic Engineering. 62: 106-115. PMID 32758536 DOI: 10.1016/J.Ymben.2020.07.008  1
2020 Daletos G, Stephanopoulos G. Protein engineering strategies for microbial production of isoprenoids. Metabolic Engineering Communications. 11: e00129. PMID 32612930 DOI: 10.1016/J.Mec.2020.E00129  0.08
2020 Yusuf R, Saez B, Sharda A, van Gastel N, Yu V, Baryawno N, Scadden EW, Acharya SS, Chattophadhyay S, Huang C, Viswanathan V, S'aulis D, Cobert J, Sykes DB, Keibler MA, ... ... Stephanopoulos G, et al. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. PMID 32458004 DOI: 10.1182/Blood.2019001808  1
2020 Daletos G, Katsimpouras C, Stephanopoulos G. Novel Strategies and Platforms for Industrial Isoprenoid Engineering. Trends in Biotechnology. PMID 32359971 DOI: 10.1016/J.Tibtech.2020.03.009  0.01
2020 Liu Y, Low ZJ, Ma X, Liang H, Stephanopoulos G, Sinskey AJ, Zhou K. Using biopolymer bodies for encapsulation of hydrophobic products in bacterium. Metabolic Engineering. PMID 32339760 DOI: 10.1016/J.Ymben.2020.04.006  1
2020 Dong W, Moon SJ, Kelleher JK, Stephanopoulos G. Dissecting mammalian cell metabolism through 13C- and 2H-isotope tracing: Interpretations at the molecular and systems levels Industrial & Engineering Chemistry Research. 59: 2593-2610. DOI: 10.1021/Acs.Iecr.9B05154  1
2019 Park JO, Liu N, Holinski KM, Emerson DF, Qiao K, Woolston BM, Xu J, Lazar Z, Islam MA, Vidoudez C, Girguis PR, Stephanopoulos G. Synergistic substrate cofeeding stimulates reductive metabolism. Nature Metabolism. 1: 643-651. PMID 32694804 DOI: 10.1038/s42255-019-0077-0  1
2019 Kuroda K, Hammer SK, Watanabe Y, Montaño López J, Fink GR, Stephanopoulos G, Ueda M, Avalos JL. Critical Roles of the Pentose Phosphate Pathway and GLN3 in Isobutanol-Specific Tolerance in Yeast. Cell Systems. PMID 31734159 DOI: 10.1016/J.Cels.2019.10.006  1
2019 Mano J, Liu N, Hammond JH, Currie DH, Stephanopoulos G. Engineering Yarrowia lipolytica for the utilization of acid whey. Metabolic Engineering. PMID 31562926 DOI: 10.1016/J.Ymben.2019.09.010  1
2019 Liu N, Santala S, Stephanopoulos G. Mixed carbon substrates: a necessary nuisance or a missed opportunity? Current Opinion in Biotechnology. 62: 15-21. PMID 31513988 DOI: 10.1016/J.Copbio.2019.07.003  1
2019 Ward VCA, Chatzivasileiou AO, Stephanopoulos G. Cell free biosynthesis of isoprenoids from isopentenol. Biotechnology and Bioengineering. PMID 31429926 DOI: 10.1002/Bit.27146  0.01
2019 Cheng F, Yu H, Stephanopoulos G. Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid. Metabolic Engineering. PMID 31301358 DOI: 10.1016/J.Ymben.2019.07.003  1
2019 Emerson DF, Stephanopoulos G. Limitations in converting waste gases to fuels and chemicals. Current Opinion in Biotechnology. 59: 39-45. PMID 30856509 DOI: 10.1016/J.Copbio.2019.02.004  1
2019 Roth T, Woolston B, Stephanopoulos G, Liu DR. Phage-assisted evolution of Bacillus methanolicus methanol dehydrogenase 2. Acs Synthetic Biology. PMID 30856338 DOI: 10.1021/Acssynbio.8B00481  1
2019 Vasdekis AE, Alanazi H, Silverman AM, Williams CJ, Canul AJ, Cliff JB, Dohnalkova AC, Stephanopoulos G. Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging. Nature Communications. 10: 848. PMID 30783105 DOI: 10.1038/S41467-019-08717-W  1
2019 Chatzivasileiou AO, Ward V, Edgar SM, Stephanopoulos G. Two-step pathway for isoprenoid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 116: 506-511. PMID 30584096 DOI: 10.1073/Pnas.1812935116  1
2018 Uranukul B, Woolston BM, Fink GR, Stephanopoulos G. Biosynthesis of monoethylene glycol in Saccharomyces cerevisiae utilizing native glycolytic enzymes. Metabolic Engineering. 51: 20-31. PMID 30268818 DOI: 10.1016/J.Ymben.2018.09.012  1
2018 Emerson DF, Woolston BM, Liu N, Donnelly M, Currie DH, Stephanopoulos G. Enhancing H -dependent growth of and CO fixation by Clostridium ljungdahlii through nitrate supplementation. Biotechnology and Bioengineering. PMID 30267586 DOI: 10.1002/bit.26847  1
2018 Abdel-Mawgoud AM, Markham KA, Palmer CM, Liu N, Stephanopoulos G, Alper HS. Metabolic engineering in the host Yarrowia lipolytica. Metabolic Engineering. PMID 30056205 DOI: 10.1016/J.Ymben.2018.07.016  1
2018 Lazar Z, Liu N, Stephanopoulos G. Holistic Approaches in Lipid Production by Yarrowia lipolytica. Trends in Biotechnology. PMID 30006239 DOI: 10.1016/J.Tibtech.2018.06.007  1
2018 Woolston BM, King JR, Reiter M, Van Hove B, Stephanopoulos G. Improving formaldehyde consumption drives methanol assimilation in engineered E. coli. Nature Communications. 9: 2387. PMID 29921903 DOI: 10.1038/s41467-018-04795-4  1
2018 Abdel-Mawgoud AM, Stephanopoulos G. Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering. Synthetic and Systems Biotechnology. 3: 3-19. PMID 29911195 DOI: 10.1016/J.Synbio.2017.12.001  1
2018 Woolston BM, Emerson DF, Currie DH, Stephanopoulos G. Rediverting carbon flux in Clostridium ljungdahlii using CRISPR Interference (CRISPRi). Metabolic Engineering. PMID 29906505 DOI: 10.1016/j.ymben.2018.06.006  1
2018 Li ZJ, Hong PH, Da YY, Li LK, Stephanopoulos G. Metabolic engineering of Escherichia coli for the production of L-malate from xylose. Metabolic Engineering. PMID 29800611 DOI: 10.1016/J.Ymben.2018.05.010  1
2018 Ward VCA, Chatzivasileiou AO, Stephanopoulos G. Metabolic engineering of Escherichia coli for the production of isoprenoids. Fems Microbiology Letters. 365. PMID 29718190 DOI: 10.1093/Femsle/Fny079  0.01
2018 Marlow JJ, Kumar A, Enalls B, Reynard LM, Tuross N, Stephanopoulos G, Girguis P. Harnessing a Methane-Fueled, Sediment-Free Mixed Microbial Community for Utilization of Distributed Sources of Natural Gas. Biotechnology and Bioengineering. PMID 29460958 DOI: 10.1002/Bit.26576  1
2017 Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 6. PMID 29239720 DOI: 10.7554/Elife.27293  1
2017 Woolston BM, Roth T, Kohale I, Liu D, Stephanopoulos G. Development of a Formaldehyde Biosensor with Application to Synthetic Methylotrophy. Biotechnology and Bioengineering. PMID 28921510 DOI: 10.1002/Bit.26455  1
2017 Li ZJ, Qiao K, Che XM, Stephanopoulos G. Metabolic engineering of Escherichia coli for the synthesis of the quadripolymer poly(glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose. Metabolic Engineering. PMID 28916461 DOI: 10.1016/J.Ymben.2017.09.003  1
2017 Cheng F, Luozhong S, Guo Z, Yu H, Stephanopoulos G. Enhanced biosynthesis of hyaluronic acid using engineered Corynebacterium glutamicum via metabolic pathway regulation. Biotechnology Journal. PMID 28869338 DOI: 10.1002/Biot.201700191  1
2017 Xu J, Liu N, Qiao K, Vogg S, Stephanopoulos G. Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630295 DOI: 10.1073/Pnas.1703321114  1
2017 Chen X, Zhang C, Zou R, Stephanopoulos G, Too HP. In vitro metabolic engineering of amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production. Acs Synthetic Biology. PMID 28520394 DOI: 10.1021/acssynbio.6b00377  1
2017 Ahsanul Islam M, Hadadi N, Ataman M, Hatzimanikatis V, Stephanopoulos G. Exploring Biochemical Pathways for Mono-Ethylene Glycol (MEG) Synthesis from Synthesis Gas. Metabolic Engineering. PMID 28433737 DOI: 10.1016/J.Ymben.2017.04.005  0.01
2017 King JR, Woolston BM, Stephanopoulos G. Designing a new entry point into isoprenoid metabolism by exploiting fructose-6-phosphate aldolase side-reactivity of Escherichia coli. Acs Synthetic Biology. PMID 28375628 DOI: 10.1021/Acssynbio.7B00072  1
2017 Xu P, Qiao K, Stephanopoulos G. Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica. Biotechnology and Bioengineering. PMID 28295166 DOI: 10.1002/Bit.26285  1
2017 Yang J, Cheng F, Yu H, Wang J, Zhi Gang G, Stephanopoulos G. Key role of the carboxyl terminus of hyaluronan synthase in processive synthesis and size control of hyaluronic acid polymers. Biomacromolecules. PMID 28192668 DOI: 10.1021/Acs.Biomac.6B01239  1
2017 Dong W, Keibler MA, Stephanopoulos G. Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis. Metabolic Engineering. PMID 28192215 DOI: 10.1016/J.Ymben.2017.02.002  1
2017 Qiao K, Wasylenko TM, Zhou K, Xu P, Stephanopoulos G. Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism. Nature Biotechnology. PMID 28092657 DOI: 10.1038/Nbt.3763  1
2017 Vasdekis AE, Silverman AM, Stephanopoulos G. Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. Plos One. 12: e0168889. PMID 28052085 DOI: 10.1371/Journal.Pone.0168889  1
2017 Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Author response: Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells Elife. DOI: 10.7554/Elife.27293.038  1
2016 Stephanopoulos G. Letter from AIChE President. Bioengineering & Translational Medicine. 1: 3. PMID 29313001 DOI: 10.1002/btm2.10006  0.01
2016 Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, et al. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nature Medicine. PMID 28024083 DOI: 10.1038/Nm.4256  1
2016 Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. Plos Pathogens. 12: e1006020. PMID 27880818 DOI: 10.1371/Journal.Ppat.1006020  1
2016 Li ZJ, Qiao K, Liu N, Stephanopoulos G. Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production. Journal of Industrial Microbiology & Biotechnology. PMID 27826725 DOI: 10.1007/S10295-016-1864-1  1
2016 Edgar S, Li FS, Qiao K, Weng JK, Stephanopoulos G. Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate. Acs Synthetic Biology. PMID 27794603 DOI: 10.1021/Acssynbio.6B00206  1
2016 Xu P, Qiao K, Ahn WS, Stephanopoulos G. Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621436 DOI: 10.1073/Pnas.1607295113  1
2016 Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 4: 16. PMID 27540483 DOI: 10.1186/S40170-016-0156-6  1
2016 Shaw AJ, Lam FH, Hamilton M, Consiglio A, MacEwen K, Brevnova EE, Greenhagen E, LaTouf WG, South CR, van Dijken H, Stephanopoulos G. Metabolic engineering of microbial competitive advantage for industrial fermentation processes. Science (New York, N.Y.). 353: 583-6. PMID 27493184 DOI: 10.1126/Science.Aaf6159  1
2016 Xu P, Rizzoni EA, Sul SY, Stephanopoulos G. Improving metabolic pathway efficiency by statistical model based multivariate regulatory metabolic engineering (MRME). Acs Synthetic Biology. PMID 27490704 DOI: 10.1021/Acssynbio.6B00187  1
2016 Zhou K, Edgar S, Stephanopoulos G. Engineering Microbes to Synthesize Plant Isoprenoids. Methods in Enzymology. 575: 225-45. PMID 27417931 DOI: 10.1016/Bs.Mie.2016.03.007  1
2016 Liu N, Qiao K, Stephanopoulos G. (13)C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica. Metabolic Engineering. PMID 27387605 DOI: 10.1016/J.Ymben.2016.06.006  1
2016 Zhang H, Stephanopoulos G. Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in Escherichia coli. Biotechnology Journal. PMID 27168529 DOI: 10.1002/Biot.201600013  1
2016 King JR, Edgar S, Qiao K, Stephanopoulos G. Accessing Nature's diversity through metabolic engineering and synthetic biology. F1000research. 5. PMID 27081481 DOI: 10.12688/F1000Research.7311.1  1
2016 Friedlander J, Tsakraklides V, Kamineni A, Greenhagen EH, Consiglio AL, MacEwen K, Crabtree DV, Afshar J, Nugent RL, Hamilton MA, Joe Shaw A, South CR, Stephanopoulos G, Brevnova EE. Engineering of a high lipid producing Yarrowia lipolytica strain. Biotechnology For Biofuels. 9: 77. PMID 27034715 DOI: 10.1186/S13068-016-0492-3  0.01
2016 Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK. Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951651 DOI: 10.1073/Pnas.1515826113  1
2016 Hu P, Chakraborty S, Kumar A, Woolston B, Liu H, Emerson D, Stephanopoulos G. Integrated bioprocess for conversion of gaseous substrates to liquids. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951649 DOI: 10.1073/Pnas.1516867113  1
2016 Silverman AM, Qiao K, Xu P, Stephanopoulos G. Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica. Applied Microbiology and Biotechnology. PMID 26915993 DOI: 10.1007/S00253-016-7376-0  1
2016 Zhang C, Chen X, Stephanopoulos G, Too HP. Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli. Biotechnology and Bioengineering. PMID 26804325 DOI: 10.1002/Bit.25943  1
2016 Li ZJ, Qiao K, Shi W, Pereira B, Zhang H, Olsen BD, Stephanopoulos G. Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli. Metabolic Engineering. PMID 26778413 DOI: 10.1016/J.Ymben.2016.01.004  1
2015 Pereira B, Li ZJ, De Mey M, Giaw Lim C, Zhang H, Hoeltgen C, Stephanopoulos G. Efficient utilization of pentoses for bioproduction of the renewable two-carbon compounds ethylene glycol and glycolate. Metabolic Engineering. PMID 26711083 DOI: 10.1016/J.Ymben.2015.12.004  1
2015 Cheng F, Gong Q, Yu H, Stephanopoulos G. High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum. Biotechnology Journal. PMID 26709615 DOI: 10.1002/Biot.201500404  1
2015 Edgar S, Zhou K, Qiao K, King JR, Simpson JH, Stephanopoulos G. Mechanistic Insights into Taxadiene Epoxidation by Taxadiene-5α-Hydroxylase. Acs Chemical Biology. PMID 26677870 DOI: 10.1021/Acschembio.5B00767  1
2015 Vasdekis AE, Silverman AM, Stephanopoulos G. Origins of Cell-to-Cell Bioprocessing Diversity and Implications of the Extracellular Environment Revealed at the Single-Cell Level. Scientific Reports. 5: 17689. PMID 26657999 DOI: 10.1038/Srep17689  1
2015 Zhang H, Li Z, Pereira B, Stephanopoulos G. Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 14: 134. PMID 26369810 DOI: 10.1186/S12934-015-0319-0  1
2015 Pereira B, Zhang H, De Mey M, Lim CG, Li ZJ, Stephanopoulos G. Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol. Biotechnology and Bioengineering. PMID 26221864 DOI: 10.1002/Bit.25717  1
2015 Tsakraklides V, Brevnova E, Stephanopoulos G, Shaw AJ. Improved Gene Targeting through Cell Cycle Synchronization. Plos One. 10: e0133434. PMID 26192309 DOI: 10.1371/Journal.Pone.0133434  1
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524: 361-5. PMID 26168401 DOI: 10.1038/Nature14587  1
2015 Zhang H, Pereira B, Li Z, Stephanopoulos G. Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences of the United States of America. PMID 26111796 DOI: 10.1073/Pnas.1506781112  1
2015 Islam MA, Zengler K, Edwards EA, Mahadevan R, Stephanopoulos G. Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25994252 DOI: 10.1039/C5Ib00095E  1
2015 Wasylenko TM, Ahn WS, Stephanopoulos G. The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica. Metabolic Engineering. 30: 27-39. PMID 25747307 DOI: 10.1016/J.Ymben.2015.02.007  1
2015 Qiao K, Imam Abidi SH, Liu H, Zhang H, Chakraborty S, Watson N, Kumaran Ajikumar P, Stephanopoulos G. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. 29: 56-65. PMID 25732624 DOI: 10.1016/J.Ymben.2015.02.005  1
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Stephanopoulos G, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/J.Copbio.2015.02.003  1
2015 Zhang C, Zou R, Chen X, Stephanopoulos G, Too HP. Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production. Applied Microbiology and Biotechnology. 99: 3825-37. PMID 25715782 DOI: 10.1007/s00253-015-6463-y  1
2015 Zhou K, Qiao K, Edgar S, Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nature Biotechnology. 33: 377-83. PMID 25558867 DOI: 10.1038/Nbt.3095  1
2015 Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, ... ... Stephanopoulos G, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Molecular Cell. 57: 95-107. PMID 25482511 DOI: 10.1016/J.Molcel.2014.10.027  1
2015 Vasdekis AE, Stephanopoulos G. Review of methods to probe single cell metabolism and bioenergetics. Metabolic Engineering. 27: 115-35. PMID 25448400 DOI: 10.1016/J.Ymben.2014.09.007  1
2015 Wasylenko TM, Stephanopoulos G. Metabolomic and (13)C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase. Biotechnology and Bioengineering. 112: 470-83. PMID 25311863 DOI: 10.1002/Bit.25447  1
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, et al. Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng08  1
2015 Okazaki A, Gameiro P, Stephanopoulos G, Iliopoulos O. Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress inVHL-deficient human renal cancer cells Cancer Research. 75: 1123-1123. DOI: 10.1158/1538-7445.Am2015-1123  1
2015 Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PNM, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, ... ... Stephanopoulos G, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation Molecular Cell. 57: 95-107. DOI: 10.1016/j.molcel.2014.10.027  1
2014 Stephanopoulos G. Gregory Stephanopoulos and colleagues reply to Screening cellular metabolic activity. Nature Biotechnology. 32: 1092-3. PMID 25380441 DOI: 10.1038/nbt.3059  0.01
2014 Lam FH, Ghaderi A, Fink GR, Stephanopoulos G. Biofuels. Engineering alcohol tolerance in yeast. Science (New York, N.Y.). 346: 71-5. PMID 25278607 DOI: 10.1126/Science.1257859  1
2014 Xu P, Li L, Zhang F, Stephanopoulos G, Koffas M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences of the United States of America. 111: 11299-304. PMID 25049420 DOI: 10.1073/Pnas.1406401111  1
2014 Zhang J, Ahn WS, Gameiro PA, Keibler MA, Zhang Z, Stephanopoulos G. 13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells. Methods in Enzymology. 542: 369-89. PMID 24862276 DOI: 10.1016/B978-0-12-416618-9.00019-4  1
2014 Yadav VG, Stephanopoulos G. Metabolic engineering: the ultimate paradigm for continuous pharmaceutical manufacturing. Chemsuschem. 7: 1847-53. PMID 24719301 DOI: 10.1002/Cssc.201301219  1
2014 Wang BL, Ghaderi A, Zhou H, Agresti J, Weitz DA, Fink GR, Stephanopoulos G. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nature Biotechnology. 32: 473-8. PMID 24705516 DOI: 10.1038/Nbt.2857  1
2014 Wegner A, Weindl D, Jäger C, Sapcariu SC, Dong X, Stephanopoulos G, Hiller K. Fragment formula calculator (FFC): determination of chemical formulas for fragment ions in mass spectrometric data. Analytical Chemistry. 86: 2221-8. PMID 24498896 DOI: 10.1021/Ac403879D  1
2013 Seow KH, Zhou L, Stephanopoulos G, Too HP. c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK. Bmc Neuroscience. 14: 153. PMID 24330599 DOI: 10.1186/1471-2202-14-153  1
2013 Chen X, Zhang C, Zou R, Zhou K, Stephanopoulos G, Too HP. Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. Plos One. 8: e79650. PMID 24278153 DOI: 10.1371/Journal.Pone.0079650  1
2013 Zou R, Zhou K, Stephanopoulos G, Too HP. Combinatorial engineering of 1-deoxy-D-xylulose 5-phosphate pathway using cross-lapping in vitro assembly (CLIVA) method. Plos One. 8: e79557. PMID 24223968 DOI: 10.1371/Journal.Pone.0079557  1
2013 Zhang C, Chen X, Zou R, Zhou K, Stephanopoulos G, Too HP. Combining genotype improvement and statistical media optimization for isoprenoid production in E. coli. Plos One. 8: e75164. PMID 24124471 DOI: 10.1371/Journal.Pone.0075164  1
2013 Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nature Communications. 4: 2236. PMID 23900562 DOI: 10.1038/Ncomms3236  1
2013 Wasylenko TM, Stephanopoulos G. Kinetic isotope effects significantly influence intracellular metabolite (13) C labeling patterns and flux determination. Biotechnology Journal. 8: 1080-9. PMID 23828762 DOI: 10.1002/Biot.201200276  1
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, ... ... Stephanopoulos G, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.Can-13-0080  1
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/J.Cell.2013.04.023  1
2013 Carlsen S, Ajikumar PK, Formenti LR, Zhou K, Phon TH, Nielsen ML, Lantz AE, Kielland-Brandt MC, Stephanopoulos G. Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology. 97: 5753-69. PMID 23636690 DOI: 10.1007/S00253-013-4877-Y  1
2013 Woolston BM, Edgar S, Stephanopoulos G. Metabolic engineering: past and future. Annual Review of Chemical and Biomolecular Engineering. 4: 259-88. PMID 23540289 DOI: 10.1146/Annurev-Chembioeng-061312-103312  1
2013 Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. The Journal of Biological Chemistry. 288: 12967-77. PMID 23504317 DOI: 10.1074/Jbc.M112.396796  1
2013 Zhou K, Zou R, Zhang C, Stephanopoulos G, Too HP. Optimization of amorphadiene synthesis in bacillus subtilis via transcriptional, translational, and media modulation. Biotechnology and Bioengineering. 110: 2556-61. PMID 23483530 DOI: 10.1002/bit.24900  1
2013 Hiller K, Wegner A, Weindl D, Cordes T, Metallo CM, Kelleher JK, Stephanopoulos G. NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. Bioinformatics (Oxford, England). 29: 1226-8. PMID 23479350 DOI: 10.1093/Bioinformatics/Btt119  1
2013 Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metabolism. 17: 372-85. PMID 23473032 DOI: 10.1016/J.Cmet.2013.02.002  1
2013 Avalos JL, Fink GR, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nature Biotechnology. 31: 335-41. PMID 23417095 DOI: 10.1038/Nbt.2509  1
2013 Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ. Loss of RBF1 changes glutamine catabolism. Genes & Development. 27: 182-96. PMID 23322302 DOI: 10.1101/Gad.206227.112  1
2013 Zhang H, Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 97: 3333-41. PMID 23179615 DOI: 10.1007/S00253-012-4544-8  1
2013 Tai M, Stephanopoulos G. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production Metabolic Engineering. 15: 1-9. PMID 23026119 DOI: 10.1016/J.Ymben.2012.08.007  1
2013 Gameiro P, Metelo A, Pérez-Carro R, Alexandra A, Wang Z, Rathmell KW, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation Cancer Research. 73: 1881-1881. DOI: 10.1158/1538-7445.Tim2013-B1  1
2013 Gameiro P, Metelo A, Pérez-Carro R, Arreolla A, Baker R, Wang Z, Olumi A, Rathmell K, López-Larrubia P, Stephanopoulos G, Iliopoulos O. Abstract 1881: Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation. Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2013-1881  1
2012 Jia G, Stephanopoulos G, Gunawan R. Ensemble kinetic modeling of metabolic networks from dynamic metabolic profiles. Metabolites. 2: 891-912. PMID 24957767 DOI: 10.3390/Metabo2040891  1
2012 Stephanopoulos G. Synthetic biology and metabolic engineering. Acs Synthetic Biology. 1: 514-25. PMID 23656228 DOI: 10.1021/Sb300094Q  0.01
2012 Jia G, Stephanopoulos G, Gunawan R. Incremental parameter estimation of kinetic metabolic network models. Bmc Systems Biology. 6: 142. PMID 23171810 DOI: 10.1186/1752-0509-6-142  1
2012 Zhou K, Zou R, Stephanopoulos G, Too HP. Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production. Microbial Cell Factories. 11: 148. PMID 23148661 DOI: 10.1186/1475-2859-11-148  1
2012 Zhou K, Zou R, Stephanopoulos G, Too HP. Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. Plos One. 7: e47513. PMID 23133596 DOI: 10.1371/journal.pone.0047513  1
2012 Keibler MA, Fendt SM, Stephanopoulos G. Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism. Biotechnology Progress. 28: 1409-18. PMID 22961737 DOI: 10.1002/btpr.1629  1
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Stephanopoulos G, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060  1
2012 Zhou H, Cheng JS, Wang BL, Fink GR, Stephanopoulos G. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metabolic Engineering. 14: 611-22. PMID 22921355 DOI: 10.1016/J.Ymben.2012.07.011  1
2012 Santos CN, Xiao W, Stephanopoulos G. Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 109: 13538-43. PMID 22869698 DOI: 10.1073/Pnas.1206346109  0.01
2012 Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak M. Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway. Endocrine-Related Cancer. 19: 557-74. PMID 22685267 DOI: 10.1530/Erc-12-0125  1
2012 Yadav VG, De Mey M, Lim CG, Ajikumar PK, Stephanopoulos G. The future of metabolic engineering and synthetic biology: towards a systematic practice. Metabolic Engineering. 14: 233-41. PMID 22629571 DOI: 10.1016/J.Ymben.2012.02.001  1
2012 Jiang M, Stephanopoulos G, Pfeifer BA. Downstream reactions and engineering in the microbially reconstituted pathway for Taxol. Applied Microbiology and Biotechnology. 94: 841-9. PMID 22460591 DOI: 10.1007/S00253-012-4016-1  1
2012 Jiang M, Stephanopoulos G, Pfeifer BA. Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds. Applied and Environmental Microbiology. 78: 2497-504. PMID 22287010 DOI: 10.1128/Aem.07391-11  1
2012 Walther JL, Metallo CM, Zhang J, Stephanopoulos G. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metabolic Engineering. 14: 162-71. PMID 22198197 DOI: 10.1016/J.Ymben.2011.12.004  1
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/Nature10602  1
2012 Boghigian BA, Salas D, Ajikumar PK, Stephanopoulos G, Pfeifer BA. Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli. Applied Microbiology and Biotechnology. 93: 1651-61. PMID 21850432 DOI: 10.1007/S00253-011-3528-4  1
2012 Wirth GJ, Fendt S, Bell EL, Keibler MA, Stephanopoulos G, Olumi AF. Abstract 3234: Metformin shifts prostate cancer metabolism towards a less malignant phenotype Cancer Research. 72: 3234-3234. DOI: 10.1158/1538-7445.Am2012-3234  1
2012 Yang J, Gameiro PA, Stephanopoulos G, Iliopoulos O. Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency Cancer Research. 72: 1132-1132. DOI: 10.1158/1538-7445.Am2012-1132  1
2012 Gameiro PA, Metallo CM, Stephanopoulos G. Systems-level analysis of cancer metabolism Systems Metabolic Engineering. 2147483647: 349-381. DOI: 10.1007/978-94-007-4534-6_11  1
2012 Tai M, Stephanopoulos GN. Metabolic engineering: Enabling technology for biofuels production Wiley Interdisciplinary Reviews: Energy and Environment. 1: 165-172. DOI: 10.1002/wene.5  1
2011 Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/Sqb.2012.76.010900  1
2011 Dugar D, Stephanopoulos G. Relative potential of biosynthetic pathways for biofuels and bio-based products. Nature Biotechnology. 29: 1074-8. PMID 22158355 DOI: 10.1038/Nbt.2055  0.01
2011 Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis. Metabolic Engineering. 13: 656-65. PMID 21907300 DOI: 10.1016/J.Ymben.2011.08.002  1
2011 Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & Development. 25: 1716-33. PMID 21852536 DOI: 10.1101/Gad.16771811  1
2011 Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Molecular Systems Biology. 7: 523. PMID 21847114 DOI: 10.1038/Msb.2011.56  1
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Stephanopoulos G, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890  1
2011 Tyo KE, Nevoigt E, Stephanopoulos G. Directed evolution of promoters and tandem gene arrays for customizing RNA synthesis rates and regulation. Methods in Enzymology. 497: 135-55. PMID 21601085 DOI: 10.1016/B978-0-12-385075-1.00006-8  1
2011 Jia G, Stephanopoulos GN, Gunawan R. Parameter estimation of kinetic models from metabolic profiles: two-phase dynamic decoupling method. Bioinformatics (Oxford, England). 27: 1964-70. PMID 21558155 DOI: 10.1093/Bioinformatics/Btr293  1
2011 Zhou K, Zhou L, Lim Q', Zou R, Stephanopoulos G, Too HP. Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCR. Bmc Molecular Biology. 12: 18. PMID 21513543 DOI: 10.1186/1471-2199-12-18  1
2011 Hiller K, Metallo C, Stephanopoulos G. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics Current Pharmaceutical Biotechnology. 12: 1075-1086. PMID 21466455 DOI: 10.2174/138920111795909096  1
2011 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. Analytical Chemistry. 83: 3211-6. PMID 21413777 DOI: 10.1021/Ac200012P  1
2011 Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular Biosystems. 7: 1409-19. PMID 21327189 DOI: 10.1039/C0Mb00309C  1
2011 Santos CN, Koffas M, Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metabolic Engineering. 13: 392-400. PMID 21320631 DOI: 10.1016/J.Ymben.2011.02.002  1
2011 Grassian AR, Metallo CM, Stephanopoulos G, Brugge JS. Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis Cancer Research. 71: 2802-2802. DOI: 10.1158/1538-7445.Am2011-2802  1
2010 Lam FH, Hartner FS, Fink GR, Stephanopoulos G. Enhancing stress resistance and production phenotypes through transcriptome engineering. Methods in Enzymology. 470: 509-32. PMID 20946823 DOI: 10.1016/S0076-6879(10)70020-3  1
2010 Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (New York, N.Y.). 330: 70-4. PMID 20929806 DOI: 10.1126/Science.1191652  1
2010 Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. Plos One. 5: e12057. PMID 20706589 DOI: 10.1371/Journal.Pone.0012057  1
2010 Jung SC, Smith CL, Lee KS, Hong ME, Kweon DH, Stephanopoulos G, Jin YS. Restoration of growth phenotypes of Escherichia coli DH5alpha in minimal media through reversal of a point mutation in purB. Applied and Environmental Microbiology. 76: 6307-9. PMID 20675450 DOI: 10.1128/Aem.01210-10  1
2010 Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KLJ. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control Proceedings of the National Academy of Sciences of the United States of America. 107: 13654-13659. PMID 20643967 DOI: 10.1073/Pnas.1006138107  1
2010 Fischer CR, Tseng HC, Tai M, Prather KLJ, Stephanopoulos G. Assessment of heterologous butyrate and butanol pathway activity by measurement of intracellular pathway intermediates in recombinant Escherichia coli Applied Microbiology and Biotechnology. 88: 265-275. PMID 20625717 DOI: 10.1007/S00253-010-2749-2  1
2010 Hiller K, Metallo CM, Kelleher JK, Stephanopoulos G. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Analytical Chemistry. 82: 6621-8. PMID 20608743 DOI: 10.1021/Ac1011574  1
2010 Klein-Marcuschamer D, Stephanopoulos G. Method for designing and optimizing random-search libraries for strain improvement. Applied and Environmental Microbiology. 76: 5541-6. PMID 20581192 DOI: 10.1128/Aem.00828-10  1
2010 Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.Can-09-3399  1
2010 Yadav VG, Stephanopoulos G. Reevaluating synthesis by biology. Current Opinion in Microbiology. 13: 371-6. PMID 20447859 DOI: 10.1016/J.Mib.2010.04.002  1
2010 Klein-Marcuschamer D, Yadav VG, Ghaderi A, Stephanopoulos GN. De Novo metabolic engineering and the promise of synthetic DNA. Advances in Biochemical Engineering/Biotechnology. 120: 101-31. PMID 20186529 DOI: 10.1007/10_2009_52  1
2010 Shukla A, Fleming KE, Chuang HF, Chau TM, Loose CR, Stephanopoulos GN, Hammond PT. Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials. 31: 2348-57. PMID 20004967 DOI: 10.1016/J.Biomaterials.2009.11.082  1
2010 Tyo KE, Fischer CR, Simeon F, Stephanopoulos G. Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations. Metabolic Engineering. 12: 187-95. PMID 19879956 DOI: 10.1016/J.Ymben.2009.10.005  1
2009 Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. The Journal of Biological Chemistry. 284: 33425-36. PMID 19758988 DOI: 10.1074/Jbc.M109.049478  1
2009 Alper H, Stephanopoulos G. Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential? Nature Reviews. Microbiology. 7: 715-23. PMID 19756010 DOI: 10.1038/Nrmicro2186  1
2009 Evans HL, Cuschieri J, Moore EE, Shapiro MB, Nathens AB, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, West MA. Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. The Journal of Trauma. 67: 384-8. PMID 19667895 DOI: 10.1097/Ta.0B013E3181Ad66A7  1
2009 Tyo KE, Ajikumar PK, Stephanopoulos G. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. Nature Biotechnology. 27: 760-5. PMID 19633654 DOI: 10.1038/Nbt.1555  1
2009 Metallo CM, Walther JL, Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Journal of Biotechnology. 144: 167-74. PMID 19622376 DOI: 10.1016/J.Jbiotec.2009.07.010  1
2009 Tyo KE, Jin YS, Espinoza FA, Stephanopoulos G. Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803. Biotechnology Progress. 25: 1236-43. PMID 19606467 DOI: 10.1002/Btpr.228  1
2009 Tanzeglock T, Soos M, Stephanopoulos G, Morbidelli M. Induction of mammalian cell death by simple shear and extensional flows. Biotechnology and Bioengineering. 104: 360-70. PMID 19575444 DOI: 10.1002/Bit.22405  0.01
2009 Moxley JF, Jewett MC, Antoniewicz MR, Villas-Boas SG, Alper H, Wheeler RT, Tong L, Hinnebusch AG, Ideker T, Nielsen J, Stephanopoulos G. Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proceedings of the National Academy of Sciences of the United States of America. 106: 6477-82. PMID 19346491 DOI: 10.1073/Pnas.0811091106  1
2009 Klein-Marcuschamer D, Santos CN, Yu H, Stephanopoulos G. Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypes. Applied and Environmental Microbiology. 75: 2705-11. PMID 19251886 DOI: 10.1128/Aem.01888-08  1
2009 Shukla A, Stephanopoulos G, Hammond PT. Antimicrobial peptide delivery from degradable polymer thin films Bioengineering, Proceedings of the Northeast Conference. DOI: 10.1109/NEBC.2009.4967812  1
2008 Stephanopoulos G. Metabolic engineering: enabling technology for biofuels production. Metabolic Engineering. 10: 293-4. PMID 19059122 DOI: 10.1016/J.Ymben.2008.10.003  0.01
2008 Fischer CR, Klein-Marcuschamer D, Stephanopoulos G. Selection and optimization of microbial hosts for biofuels production. Metabolic Engineering. 10: 295-304. PMID 18655844 DOI: 10.1016/J.Ymben.2008.06.009  1
2008 Yu H, Tyo K, Alper H, Klein-Marcuschamer D, Stephanopoulos G. A high-throughput screen for hyaluronic acid accumulation in recombinant Escherichia coli transformed by libraries of engineered sigma factors. Biotechnology and Bioengineering. 101: 788-96. PMID 18500764 DOI: 10.1002/Bit.21947  1
2008 Yoo H, Antoniewicz MR, Stephanopoulos G, Kelleher JK. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. The Journal of Biological Chemistry. 283: 20621-7. PMID 18364355 DOI: 10.1074/Jbc.M706494200  1
2008 Styczynski MP, Jensen KL, Rigoutsos I, Stephanopoulos G. BLOSUM62 miscalculations improve search performance. Nature Biotechnology. 26: 274-275. PMID 18327232 DOI: 10.1038/Nbt0308-274  1
2008 Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metabolism. 7: 125-34. PMID 18249172 DOI: 10.1016/J.Cmet.2007.11.013  1
2008 Alper H, Stephanopoulos G. Uncovering the gene knockout landscape for improved lycopene production in E. coli Applied Microbiology and Biotechnology. 78: 801-810. PMID 18239914 DOI: 10.1007/S00253-008-1373-X  1
2008 Yu H, Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metabolic Engineering. 10: 24-32. PMID 17959405 DOI: 10.1016/J.Ymben.2007.09.001  1
2008 Young JD, Walther JL, Antoniewicz MR, Yoo H, Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnology and Bioengineering. 99: 686-99. PMID 17787013 DOI: 10.1002/Bit.21632  1
2008 Stephanopoulos G. Integrating cell-wide data for better diagnosis and elucidation of cell physiology Journal of Biotechnology. 136. DOI: 10.1016/J.Jbiotec.2008.07.025  0.01
2007 Ng JK, Ajikumar PK, Tang YC, Lee JY, Stephanopoulos G, Too HP. Spatially addressable protein array: ssDNA-directed assembly for antibody microarray. Electrophoresis. 28: 4638-44. PMID 18008302 DOI: 10.1002/Elps.200700183  1
2007 Lütke-Eversloh T, Santos CNS, Stephanopoulos G. Perspectives of biotechnological production of l -tyrosine and its applications Applied Microbiology and Biotechnology. 77: 751-762. PMID 17968539 DOI: 10.1007/S00253-007-1243-Y  0.01
2007 Lütke-Eversloh T, Stephanopoulos G. A semi-quantitative high-throughput screening method for microbial l -tyrosine production in microtiter plates Journal of Industrial Microbiology & Biotechnology. 34: 807-811. PMID 17926073 DOI: 10.1007/S10295-007-0257-X  0.01
2007 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Analytical Chemistry. 79: 7554-9. PMID 17822305 DOI: 10.1021/Ac0708893  1
2007 Alevizos I, Misra J, Bullen J, Basso G, Kelleher J, Mantzoros C, Stephanopoulos G. Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice. Cell Cycle (Georgetown, Tex.). 6: 1631-8. PMID 17603298 DOI: 10.4161/Cc.6.13.4380  1
2007 Misra J, Alevizos I, Hwang D, Stephanopoulos G, Stephanopoulos G. Linking physiology and transcriptional profiles by quantitative predictive models. Biotechnology and Bioengineering. 98: 252-60. PMID 17551988 DOI: 10.1002/Bit.21540  1
2007 Jin YS, Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metabolic Engineering. 9: 337-47. PMID 17509919 DOI: 10.1016/J.Ymben.2007.03.003  1
2007 Antoniewicz MR, Kraynie DF, Laffend LA, González-Lergier J, Kelleher JK, Stephanopoulos G. Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol. Metabolic Engineering. 9: 277-92. PMID 17400499 DOI: 10.1016/J.Ymben.2007.01.003  1
2007 Ajikumar PK, Ng JK, Tang YC, Lee JY, Stephanopoulos G, Too HP. Carboxyl-terminated dendrimer-coated bioactive interface for protein microarray: high-sensitivity detection of antigen in complex biological samples. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 5670-7. PMID 17388617 DOI: 10.1021/La063717U  1
2007 Alper H, Stephanopoulos G. Global transcription machinery engineering: A new approach for improving cellular phenotype Metabolic Engineering. 9: 258-267. PMID 17292651 DOI: 10.1016/J.Ymben.2006.12.002  1
2007 Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Molecular and Cellular Biology. 27: 2830-40. PMID 17283057 DOI: 10.1128/Mcb.00079-07  1
2007 Loose CR, Langer RS, Stephanopoulos GN. Optimization of protein fusion partner length for maximizing in vitro translation of peptides. Biotechnology Progress. 23: 444-51. PMID 17269789 DOI: 10.1021/Bp060277O  1
2007 Styczynski MP, Moxley JF, Tong LV, Walther JL, Jensen KL, Stephanopoulos GN. Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery. Analytical Chemistry. 79: 966-73. PMID 17263323 DOI: 10.1021/ac0614846  1
2007 Tyo KE, Alper HS, Stephanopoulos GN. Expanding the metabolic engineering toolbox: more options to engineer cells Trends in Biotechnology. 25: 132-137. PMID 17254656 DOI: 10.1016/j.tibtech.2007.01.003  1
2007 Lütke-Eversloh T, Stephanopoulos G. L-tyrosine production by deregulated strains of Escherichia coli. Applied Microbiology and Biotechnology. 75: 103-110. PMID 17221195 DOI: 10.1007/S00253-006-0792-9  0.01
2007 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metabolic Engineering. 9: 68-86. PMID 17088092 DOI: 10.1016/J.Ymben.2006.09.001  1
2006 Alper H, Moxley J, Nevoigt E, Fink GR, Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science (New York, N.Y.). 314: 1565-8. PMID 17158319 DOI: 10.1126/Science.1131969  1
2006 Antoniewicz MR, Stephanopoulos G, Kelleher JK. Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway. Metabolomics : Official Journal of the Metabolomic Society. 2: 41-52. PMID 17066125 DOI: 10.1007/S11306-006-0018-2  1
2006 Nevoigt E, Kohnke J, Fischer CR, Alper H, Stahl U, Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae Applied and Environmental Microbiology. 72: 5266-5273. PMID 16885275 DOI: 10.1128/Aem.00530-06  1
2006 Styczynski MP, Fischer CR, Stephanopoulos GN. The intelligent design of evolution. Molecular Systems Biology. 2: 2006.0020. PMID 16738565 DOI: 10.1038/msb4100065  1
2006 Jensen K, Alper H, Fischer C, Stephanopoulos G. Identifying functionally important mutations from phenotypically diverse sequence data Applied and Environmental Microbiology. 72: 3696-3701. PMID 16672519 DOI: 10.1128/Aem.72.5.3696-3701.2006  1
2006 Antoniewicz MR, Kelleher JK, Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metabolic Engineering. 8: 324-37. PMID 16631402 DOI: 10.1016/J.Ymben.2006.01.004  1
2006 Alper H, Miyaoku K, Stephanopoulos G. Characterization of lycopene-overproducing E. coli strains in high cell density fermentations Applied Microbiology and Biotechnology. 72: 968-974. PMID 16502313 DOI: 10.1007/S00253-006-0357-Y  1
2006 Fischer CR, Alper H, Nevoigt E, Jensen KL, Stephanopoulos G. Response to Hammer et al.: Tuning genetic control - Importance of thorough promoter characterization versus generating promoter diversity Trends in Biotechnology. 24: 55-56. PMID 16380177 DOI: 10.1016/J.Tibtech.2005.12.001  1
2006 Alper HS, Fischer C, Nevoigt E, Stephanopoulos G. Erratum: Tuning genetic control through promoter engineering (Proceedings of the National Academy of Sciences of the United States of America (September 6, 2005) 102, 36 (12678-12683) DOI: 10.1073/pnas.0504604102) Proceedings of the National Academy of Sciences of the United States of America. 103. DOI: 10.1073/Pnas.0511314103  1
2005 Jin YS, Alper H, Yang YT, Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Applied and Environmental Microbiology. 71: 8249-56. PMID 16332810 DOI: 10.1128/Aem.71.12.8249-8256.2005  1
2005 Lütke-Eversloh T, Stephanopoulos G. Feedback Inhibition of Chorismate Mutase/Prephenate Dehydrogenase (TyrA) of Escherichia coli: Generation and Characterization of Tyrosine-Insensitive Mutants Applied and Environmental Microbiology. 71: 7224-7228. PMID 16269762 DOI: 10.1128/Aem.71.11.7224-7228.2005  0.01
2005 Alper H, Fischer C, Nevoigt E, Stephanopoulos G. Tuning genetic control through promoter engineering Proceedings of the National Academy of Sciences of the United States of America. 102: 12678-12683. PMID 16123130 DOI: 10.1073/Pnas.0504604102  1
2005 Raab RM, Bullen J, Kelleher J, Mantzoros C, Stephanopoulos G. Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction. Nutrition & Metabolism. 2: 15. PMID 15985155 DOI: 10.1186/1743-7075-2-15  1
2005 Alper H, Jin YS, Moxley JF, Stephanopoulos G. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metabolic Engineering. 7: 155-64. PMID 15885614 DOI: 10.1016/J.Ymben.2004.12.003  1
2005 Alper H, Miyaoku K, Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets Nature Biotechnology. 23: 612-616. PMID 15821729 DOI: 10.1038/Nbt1083  1
2005 Villas-Bôas SG, Moxley JF, Akesson M, Stephanopoulos G, Nielsen J. High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts. The Biochemical Journal. 388: 669-77. PMID 15667247 DOI: 10.1042/Bj20041162  1
2005 Styczynski MP, Stephanopoulos G. Overview of computational methods for the inference of gene regulatory networks Computers & Chemical Engineering. 29: 519-534. DOI: 10.1016/J.Compchemeng.2004.08.029  1
2004 Heijnen JJ, van Gulik WM, Shimizu H, Stephanopoulos G. Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data. Metabolic Engineering. 6: 391-400. PMID 15491867 DOI: 10.1016/J.Ymben.2004.07.002  1
2004 Stephanopoulos G, Alper H, Moxley J. Exploiting biological complexity for strain improvement through systems biology. Nature Biotechnology. 22: 1261-7. PMID 15470466 DOI: 10.1038/Nbt1016  1
2004 Raab RM, Stephanopoulos G. Dynamics of gene silencing by RNA interference Biotechnology and Bioengineering. 88: 121-132. PMID 15389485 DOI: 10.1002/Bit.20216  1
2004 Bullen JW, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. American Journal of Physiology. Endocrinology and Metabolism. 287: E662-70. PMID 15361355 DOI: 10.1152/Ajpendo.00114.2004  1
2004 Schmitt WA, Raab RM, Stephanopoulos G. Elucidation of gene interaction networks through time-lagged correlation analysis of transcriptional data. Genome Research. 14: 1654-63. PMID 15289483 DOI: 10.1101/Gr.2439804  1
2004 Lynch MD, Gill RT, Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metabolic Engineering. 6: 177-85. PMID 15256207 DOI: 10.1016/J.Ymben.2004.01.002  1
2004 Yoo H, Stephanopoulos G, Kelleher JK. Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes. Journal of Lipid Research. 45: 1324-32. PMID 15102881 DOI: 10.1194/Jlr.M400031-Jlr200  1
2004 Jung GY, Stephanopoulos G. A functional protein chip for pathway optimization and in vitro metabolic engineering. Science (New York, N.Y.). 304: 428-31. PMID 15087547 DOI: 10.1126/Science.1096920  0.56
2004 Lee K, Hwang D, Yokoyama T, Stephanopoulos G, Stephanopoulos GN, Yarmush ML. Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics (Oxford, England). 20: 959-69. PMID 14751977 DOI: 10.1093/Bioinformatics/Bth015  1
2004 Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH, Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiological Genomics. 16: 229-39. PMID 14645737 DOI: 10.1152/Physiolgenomics.00087.2001  1
2004 Wong MS, Raab RM, Rigoutsos I, Stephanopoulos GN, Kelleher JK. Metabolic and transcriptional patterns accompanying glutamine depletion and repletion in mouse hepatoma cells: a model for physiological regulatory networks. Physiological Genomics. 16: 247-55. PMID 14612591 DOI: 10.1152/physiolgenomics.00088.2003  1
2003 Schmitt WA, Stephanopoulos G. Prediction of transcriptional profiles of Synechocystis PCC6803 by dynamic autoregressive modeling of DNA microarray data. Biotechnology and Bioengineering. 84: 855-63. PMID 14708126 DOI: 10.1002/Bit.10843  1
2003 Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML. Induction of a hypermetabolic state in cultured hepatocytes by glucagon and H2O2. Metabolic Engineering. 5: 221-9. PMID 14642350 DOI: 10.1016/S1096-7176(03)00042-9  1
2003 Klapa MI, Aon JC, Stephanopoulos G. Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. European Journal of Biochemistry / Febs. 270: 3525-42. PMID 12919317 DOI: 10.1046/J.1432-1033.2003.03732.X  1
2003 Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML. Profiling of dynamic changes in hypermetabolic livers. Biotechnology and Bioengineering. 83: 400-15. PMID 12800135 DOI: 10.1002/Bit.10682  1
2003 Koffas MA, Jung GY, Stephanopoulos G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metabolic Engineering. 5: 32-41. PMID 12749842 DOI: 10.1016/S1096-7176(03)00002-8  1
2003 Klapa MI, Aon JC, Stephanopoulos G. Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination. Biotechniques. 34: 832-6, 838, 840 pass. PMID 12703309 DOI: 10.2144/03344Pt02  1
2003 Chan C, Hwang D, Stephanopoulos GN, Yarmush ML, Stephanopoulos G. Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnology Progress. 19: 580-98. PMID 12675604 DOI: 10.1021/Bp025660H  1
2003 Hwang D, Alevizos I, Schmitt WA, Misra J, Ohyama H, Todd R, Mahadevappa M, Warrington JA, Stephanopoulos G, Wong DT, Stephanopoulos G. Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncology. 39: 259-68. PMID 12618198 DOI: 10.1016/S1368-8375(02)00108-2  1
2003 Varela C, Agosin E, Baez M, Klapa M, Stephanopoulos G. Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress. Applied Microbiology and Biotechnology. 60: 547-55. PMID 12536254 DOI: 10.1007/S00253-002-1120-7  0.01
2002 Yuk IH, Wildt S, Jolicoeur M, Wang DI, Stephanopoulos G. A GFP-based screen for growth-arrested, recombinant protein-producing cells. Biotechnology and Bioengineering. 79: 74-82. PMID 17590933 DOI: 10.1002/Bit.10293  0.04
2002 Koffas MA, Jung GY, Aon JC, Stephanopoulos G. Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Applied and Environmental Microbiology. 68: 5422-8. PMID 12406733 DOI: 10.1128/Aem.68.11.5422-5428.2002  1
2002 Hwang D, Schmitt WA, Stephanopoulos G, Stephanopoulos G. Determination of minimum sample size and discriminatory expression patterns in microarray data. Bioinformatics (Oxford, England). 18: 1184-93. PMID 12217910 DOI: 10.1093/Bioinformatics/18.9.1184  1
2002 Stephanopoulos G, Hwang D, Schmitt WA, Misra J, Stephanopoulos G. Mapping physiological states from microarray expression measurements. Bioinformatics (Oxford, England). 18: 1054-63. PMID 12176828 DOI: 10.1093/Bioinformatics/18.8.1054  1
2002 Misra J, Schmitt W, Hwang D, Hsiao LL, Gullans S, Stephanopoulos G, Stephanopoulos G. Interactive exploration of microarray gene expression patterns in a reduced dimensional space. Genome Research. 12: 1112-20. PMID 12097349 DOI: 10.1101/Gr.225302  1
2002 Gill RT, Katsoulakis E, Schmitt W, Taroncher-Oldenburg G, Misra J, Stephanopoulos G. Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803. Journal of Bacteriology. 184: 3671-81. PMID 12057963 DOI: 10.1128/Jb.184.13.3671-3681.2002  1
2002 Gill RT, Wildt S, Yang YT, Ziesman S, Stephanopoulos G. Genome-wide screening for trait conferring genes using DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America. 99: 7033-8. PMID 11997466 DOI: 10.1073/Pnas.102154799  0.52
2002 Stafford DE, Yanagimachi KS, Lessard PA, Rijhwani SK, Sinskey AJ, Stephanopoulos G. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proceedings of the National Academy of Sciences of the United States of America. 99: 1801-6. PMID 11854482 DOI: 10.1073/Pnas.032681699  1
2002 Follstad BD, Wang DI, Stephanopoulos G. Mitochondrial membrane potential selects hybridomas yielding high viability in fed-batch cultures. Biotechnology Progress. 18: 1-5. PMID 11822893 DOI: 10.1021/Bp010132B  1
2002 Stephanopoulos G, Gill RT. After a decade of progress, an expanded role for metabolic engineering. Advances in Biochemical Engineering/Biotechnology. 73: 1-8. PMID 11816808 DOI: 10.1007/3-540-45300-8_1  0.6
2002 Walton SP, Stephanopoulos GN, Yarmush ML, Roth CM. Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. Biophysical Journal. 82: 366-77. PMID 11751323 DOI: 10.1016/S0006-3495(02)75401-5  1
2001 Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, MacDonald ME, Milford EL, ... ... Stephanopoulos G, ... ... Stephanopoulos G, et al. A compendium of gene expression in normal human tissues. Physiological Genomics. 7: 97-104. PMID 11773596 DOI: 10.1152/Physiolgenomics.00040.2001  1
2001 Yanagimachi KS, Stafford DE, Dexter AF, Sinskey AJ, Drew S, Stephanopoulos G. Application of radiolabeled tracers to biocatalytic flux analysis. European Journal of Biochemistry. 268: 4950-60. PMID 11559364 DOI: 10.1046/J.0014-2956.2001.02426.X  1
2001 Stephanopoulos G, Kelleher J. Biochemistry: How to make a superior cell Science. 292: 2024-2025. PMID 11408647 DOI: 10.1126/Science.1062556  1
2001 Balcarcel RR, Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnology and Bioengineering. 76: 1-10. PMID 11400101 DOI: 10.1002/Bit.1020  0.01
2001 Stephanopoulos G, Schmitt WA. Systems Biology: an emerging theme in biological research Computer Aided Chemical Engineering. 9: 55-68. DOI: 10.1016/S1570-7946(01)80006-7  1
2001 Stephanopoulos G. IN MEMORIAM: Jay Bailey (1944–2001) Metabolic Engineering. 3: 393-394. DOI: 10.1006/Mben.2001.0201  0.01
2000 Lee K, Berthiaume F, Stephanopoulos GN, Yarmush DM, Yarmush ML. Metabolic flux analysis of postburn hepatic hypermetabolism Metabolic Engineering. 2: 312-327. PMID 11120643 DOI: 10.1006/Mben.2000.0160  1
2000 Stephanopoulos G. Bioinformatics and metabolic engineering Metabolic Engineering. 2: 157-158. PMID 11056058 DOI: 10.1006/Mben.2000.0157  0.01
2000 Shanks JV, Stephanopoulos G. Biochemical engineering. Bridging the gap between gene and product. Current Opinion in Biotechnology. 11: 169-70. PMID 10809544 DOI: 10.1016/S0958-1669(00)00076-8  1
2000 Reinecke M, Stephanopoulos G. Flow injection analysis for simultaneous quantification of prolactin concentration and glycosylation macroheterogeneity in cell culture samples Cytotechnology. 34: 237-242. DOI: 10.1023/A:1008170023099  1
1999 Stephanopoulos G. Metabolic fluxes and metabolic engineering. Metabolic Engineering. 1: 1-11. PMID 10935750 DOI: 10.1006/Mben.1998.0101  0.01
1999 Simpson TW, Follstad BD, Stephanopoulos G. Analysis of the pathway structure of metabolic networks. Journal of Biotechnology. 71: 207-23. PMID 10483107 DOI: 10.1016/S0168-1656(99)00023-1  1
1999 Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML. Metabolic flux analysis: A powerful tool for monitoring tissue function Tissue Engineering. 5: 347-368. PMID 10477857 DOI: 10.1089/Ten.1999.5.347  1
1999 Walton SP, Stephanopoulos GN, Yarmush ML, Roth CM. Prediction of antisense oligonucleotide binding affinity to a structured RNA target Biotechnology and Bioengineering. 65: 1-9. PMID 10440665 DOI: 10.1002/(Sici)1097-0290(19991005)65:1<1::Aid-Bit1>3.0.Co;2-F  1
1999 Treadway SL, Yanagimachi KS, Lankenau E, Lessard PA, Stephanopoulos G, Sinskey AJ. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Applied Microbiology and Biotechnology. 51: 786-93. PMID 10422226 DOI: 10.1007/S002530051463  1
1999 Follstad BD, Balcarcel RR, Stephanopoulos G, Wang DI. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnology and Bioengineering. 63: 675-83. PMID 10397824 DOI: 10.1002/(Sici)1097-0290(19990620)63:6<675::Aid-Bit5>3.0.Co;2-R  1
1999 Shaw-Reid CA, McCormick MM, Sinskey AJ, Stephanopoulos G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 51: 325-33. PMID 10222581 DOI: 10.1007/S002530051398  1
1999 Klapa MI, Park SM, Sinskey AJ, Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnology and Bioengineering. 62: 375-391. PMID 10099550 DOI: 10.1002/(Sici)1097-0290(19990220)62:4<375::Aid-Bit1>3.0.Co;2-O  1
1999 Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, Wang DI. Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells. Biotechnology and Bioengineering. 62: 336-47. PMID 10099545 DOI: 10.1002/(SICI)1097-0290(19990205)62:3<336::AID-BIT10>3.0.CO;2-N  1
1999 Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, Wang DI. Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium. Biotechnology and Bioengineering. 62: 324-35. PMID 10099544 DOI: 10.1002/(Sici)1097-0290(19990205)62:3<324::Aid-Bit9>3.0.Co;2-C  1
1999 Goswami J, Sinskey AJ, Steller H, Stephanopoulos GN, Wang DI. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnology and Bioengineering. 62: 632-40. PMID 9951521 DOI: 10.1002/(Sici)1097-0290(19990320)62:6<632::Aid-Bit2>3.0.Co;2-I  1
1999 Park SM, Klapa MI, Sinskey AJ, Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications Biotechnology and Bioengineering. 62: 392-401. PMID 9921151 DOI: 10.1002/(Sici)1097-0290(19990220)62:4<392::Aid-Bit2>3.0.Co;2-S  1
1998 Simpson TW, Shimizu H, Stephanopoulos G. Experimental determination of group flux control coefficients in metabolic networks Biotechnology and Bioengineering. 58: 149-53. PMID 10191384 DOI: 10.1002/(Sici)1097-0290(19980420)58:2/3<149::Aid-Bit6>3.0.Co;2-L  1
1998 Chung JD, Sinskey AJ, Stephanopoulos G. Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line. Biotechnology and Bioengineering. 57: 164-71. PMID 10099191 DOI: 10.1002/(Sici)1097-0290(19980120)57:2<164::Aid-Bit5>3.0.Co;2-L  1
1998 Koffas MAG, Ramamoorthi R, Pine WA, Sinskey AJ, Stephanopoulos G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene Applied Microbiology and Biotechnology. 50: 346-352. PMID 9802220 DOI: 10.1007/S002530051302  1
1998 Bicciato S, Kamimura RT, Shimizu H, Stephanopoulos G. Quantification of Data Clusters for Bioprocess Performance Classification via Artificial Neural Networks Ifac Proceedings Volumes. 31: 439-444. DOI: 10.1016/S1474-6670(17)40225-4  1
1998 Kamimura RT, Bicciato S, Shimizu H, Stephanopoulos G. Database Mining Tools for Bioprocess Analysis Ifac Proceedings Volumes. 31: 405-410. DOI: 10.1016/S1474-6670(17)40219-9  1
1997 Park SM, Sinskey AJ, Stephanopoulos G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnology and Bioengineering. 55: 864-79. PMID 18636597 DOI: 10.1002/(Sici)1097-0290(19970920)55:6<864::Aid-Bit5>3.0.Co;2-E  1
1997 Chung JD, Zabel C, Sinskey AJ, Stephanopoulos G. Extension of Sp2/0 hybridoma cell viability through interleukin-6 supplementation. Biotechnology and Bioengineering. 55: 439-46. PMID 18636502 DOI: 10.1002/(Sici)1097-0290(19970720)55:2<439::Aid-Bit21>3.0.Co;2-A  1
1997 Stephanopoulos G, Locher G, Duff MJ, Kamimura R, Stephanopoulos G. Fermentation database mining by pattern recognition. Biotechnology and Bioengineering. 53: 443-52. PMID 18634039 DOI: 10.1002/(Sici)1097-0290(19970305)53:5<443::Aid-Bit1>3.0.Co;2-H  1
1997 Stephanopoulos G, Simpson TW. Flux amplification in complex metabolic networks Chemical Engineering Science. 52: 2607-2627. DOI: 10.1016/S0009-2509(97)00077-8  1
1996 Shelikoff M, Sinskey AJ, Stephanopoulos G. A modeling framework for the study of protein glycosylation. Biotechnology and Bioengineering. 50: 73-90. PMID 18626901 DOI: 10.1002/(Sici)1097-0290(19960405)50:1<73::Aid-Bit9>3.0.Co;2-Z  1
1996 Grampp GE, Applegate MA, Stephanopoulos G. Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone. A comparison of single-pass and recycle modes of operation Biotechnology Progress. 12: 837-846. PMID 8983208 DOI: 10.1021/Bp960066R  1
1996 Kamimura R, Konstantinov K, Stephanopoulos G. Knowledge-based systems, artificial neural networks and pattern recognition: applications to biotechnological processes Current Opinion in Biotechnology. 7: 231-234. PMID 8791334 DOI: 10.1016/S0958-1669(96)80018-8  0.01
1996 Locher G, Stephanopoulos G, Stephanopoulos G, Schügerl K. Ein Ansatz zur automatischen Umwandlung von Rohdaten in Regeln At-Automatisierungstechnik. 44: 61-70. DOI: 10.1524/Auto.1996.44.2.61  1
1995 Chen K, Stephanopoulos GN, Sinskey AJ, Lodish HF. Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3. Bio/Technology (Nature Publishing Company). 13: 1191-7. PMID 9636291 DOI: 10.1038/Nbt1195-1191  1
1995 Zupke C, Sinskey AJ, Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Applied Microbiology and Biotechnology. 44: 27-36. PMID 8579834 DOI: 10.1007/Bf00164476  1
1995 Colón GE, Jetten MS, Nguyen TT, Gubler ME, Follettie MT, Sinskey AJ, Stephanopoulos G. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Applied and Environmental Microbiology. 61: 74-8. PMID 7887627 DOI: 10.1128/Aem.61.1.74-78.1995  1
1995 Simpson TW, Colón GE, Stephanopoulos G. Two paradigms of metabolic engineering applied to amino acid biosynthesis. Biochemical Society Transactions. 23: 381-7. PMID 7672413 DOI: 10.1042/Bst0230381  1
1995 Colón GE, Nguyen TT, Jetten MS, Sinskey AJ, Stephanopoulos G. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Applied Microbiology and Biotechnology. 43: 482-8. PMID 7632398 DOI: 10.1007/Bf00218453  1
1995 Chung JD, Conner S, Stephanopoulos G. Flow cytometric study of differentiating cultures of Bacillus subtilis Cytometry. 20: 324-333. PMID 7587720 DOI: 10.1002/Cyto.990200408  1
1995 Stephanopoulos G, Locher G, Duff M. Pattern Recognition Methods for Fermentation Database Mining Ifac Proceedings Volumes. 28: 195-198. DOI: 10.1016/S1474-6670(17)45625-4  1
1994 Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wang DI, Whitesides GM, Ingber DE. Engineering cell shape and function. Science (New York, N.Y.). 264: 696-8. PMID 8171320 DOI: 10.1126/Science.8171320  1
1994 Bakshi BR, Locher G, Stephanopoulos G, Stephanopoulous G. Analysis of operating data for evaluation, diagnosis and control of batch operations Journal of Process Control. 4: 179-194. DOI: 10.1016/0959-1524(94)80040-5  1
1994 Locher G, Bakshi B, Stephanopoulos G, Schügerl K. „Database mining” mit Hilfe von Trends, Wavelet‐Transformation und Klassifizierungsbäumen Chemie Ingenieur Technik. 66: 541-543. DOI: 10.1002/Cite.330660424  1
1993 Park S, Stephanopoulos G. Packed bed bioreactor with porous ceramic beads for animal cell culture. Biotechnology and Bioengineering. 41: 25-34. PMID 18601242 DOI: 10.1002/Bit.260410105  0.16
1993 Stephanopoulos G, Sinskey AJ. Metabolic engineering — methodologies and future prospects Trends in Biotechnology. 11: 392-396. PMID 7764086 DOI: 10.1016/0167-7799(93)90099-U  1
1992 Applegate MA, Stephanopoulos G. Development of a single-pass ceramic matrix bioreactor for large-scale mammalian cell culture. Biotechnology and Bioengineering. 40: 1056-68. PMID 18601214 DOI: 10.1002/Bit.260400909  1
1992 Kennedy MJ, Thakur MS, Wang DI, Stephanopoulos GN. Estimating cell concentration in the presence of suspended solids: a light scatter technique. Biotechnology and Bioengineering. 40: 875-88. PMID 18601194 DOI: 10.1002/bit.260400803  0.01
1992 Grampp GE, Sambanis A, Stephanopoulos GN. Use of regulated secretion in protein production from animal cells: an overview Advances in Biochemical Engineering/Biotechnology. 46: 35-62. PMID 1636482  1
1992 Kennedy MJ, Thakur MS, Wang DI, Stephanopoulos GN. Techniques for the estimation of cell concentration in the presence of suspended solids. Biotechnology Progress. 8: 375-81. PMID 1369219 DOI: 10.1021/bp00017a001  0.01
1992 Saner U, Stephanopoulos G. Application of Pattern Recognition Techniques to Fermentation Data Analysis Ifac Proceedings Volumes. 25: 123-128. DOI: 10.1016/S1474-6670(17)50337-7  0.01
1991 Stephanopoulos G, Vallino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science. 252: 1675-1681. PMID 1904627 DOI: 10.1126/Science.1904627  0.01
1991 Sambanis A, Lodish HF, Stephanopoulos G. A model of secretory protein trafficking in recombinant AtT-20 cells Biotechnology and Bioengineering. 38: 280-295. DOI: 10.1002/Bit.260380310  1
1990 Mavrovouniotis ML, Stephanopoulos G, Stephanopoulos G. Computer-Aided Synthesis Of Biochemical Pathways Biotechnology and Bioengineering. 36: 1119-1132. PMID 18595053 DOI: 10.1002/Bit.260361107  0.01
1990 Sambanis A, Stephanopoulos G, Lodish HF. Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells Cytotechnology. 4: 111-119. PMID 1367038 DOI: 10.1007/Bf00365091  1
1990 Sambanis A, Stephanopoulos G, Sinskey AJ, Lodish HF. Use of regulated secretion in protein production from animal cells: An evaluation with the AtT-20 model cell line Biotechnology and Bioengineering. 35: 771-780. DOI: 10.1002/Bit.260350804  1
1989 Mavrovouniotis ML, Stephanopoulos G, Stephanopoulos G. Formal modeling of approximate relations in biochemical systems. Biotechnology and Bioengineering. 34: 196-206. PMID 18588093 DOI: 10.1002/Bit.260340208  0.01
1989 Chattaway T, Stephanopoulos G. Adaptive estimation of bioreactors: monitoring plasmid instability Chemical Engineering Science. 44: 41-48. DOI: 10.1016/0009-2509(89)85230-3  0.01
1986 Kornfield J, Stephanopoulos G, Voecks GE. Oxygen transfer in membrane-ceramic composite materials for immobilized-cell monolithic reactors. Biotechnology Progress. 2: 98-104. PMID 20568196 DOI: 10.1002/Btpr.5420020209  0.12
1986 Stephanopoulos G, Stephanopoulos G. Artificial intelligence in the development and design of biochemical processes Trends in Biotechnology. 4: 241-249. DOI: 10.1016/0167-7799(86)90118-6  0.01
1985 Stephanopoulos G, San K-, Davison BH. A novel bioreactor-cell precipitator combination for high-cell density, high-flow fermentations. Biotechnology Progress. 1: 250-259. PMID 20568173 DOI: 10.1002/Btpr.5420010409  0.04
1985 Liepmann D, Stephanopoulos G. Development and global sensitivity analysis of a closed ecosystem model Ecological Modelling. 30: 13-47. DOI: 10.1016/0304-3800(85)90035-3  1
1984 Wang NS, Stephanopoulos GN, Erickson LE. Computer applications to fermentation processes Critical Reviews in Biotechnology. 2: 1-103. DOI: 10.3109/07388558409084661  1
1984 Stephanopoulos G, San KY. Studies on on-line bioreactor identification. I. Theory Biotechnology and Bioengineering. 26: 1176-1188. DOI: 10.1002/Bit.260261006  1
1981 Stephanopoulos G, Fredrickson AG. Extinction probabilities in microbial predation: A birth and death approach Bulletin of Mathematical Biology. 43: 165-181. DOI: 10.1016/S0092-8240(81)90014-8  1
1981 Michalopoulos PG, Stephanopoulos G. An application of shock wave theory to traffic signal control Transportation Research Part B. 15: 35-51. DOI: 10.1016/0191-2615(81)90045-X  1
1980 Stephanopoulos G, Stephanopoulos G. An Alternative Approach To The Optimization Of Constrained Design Problems Chemical Engineering Communications. 4: 173-179. DOI: 10.1080/00986448008935901  0.01
1980 Stephanopoulos G, Westerberg AW. Modular Design Of Heat Exchanger Networks Chemical Engineering Communications. 4: 119-126. DOI: 10.1080/00986448008935895  0.04
1979 Stephanopoulos G, Schuelke LM, Stephanopoulos G. A decomposition method for the stability analysis of large microbial systems. Theoretical Population Biology. 16: 126-143. PMID 538730 DOI: 10.1016/0040-5809(79)90009-1  0.01
1979 Stephanopoulos G, Fredrickson AG. Coexistence of photosynthetic microorganisms with growth rates depending on the spectral quality of light Bulletin of Mathematical Biology. 41: 525-542. DOI: 10.1016/S0092-8240(79)80006-3  1
1979 Stephanopoulos G, Michalopoulos PG. Modelling and analysis of traffic queue dynamics at signalized intersections Transportation Research Part a: General. 13: 295-307. DOI: 10.1016/0191-2607(79)90028-1  1
1979 Stephanopoulos G, Aris R, Fredrickson AG. A stochastic analysis of the growth of competing microbial populations in a continuous biochemical reactor Mathematical Biosciences. 45: 99-135. DOI: 10.1016/0025-5564(79)90098-1  1
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